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Subpellicular subdomains drive cell shape in Trypanosoma brucei

Trypanosoma brucei, the causative agent of African sleeping sickness, has a cell shape that is created by the subpellicular microtubule array. The microtubules of the array are shaped and regulated by differentially localized microtubule-associated proteins that are organized into discrete subdomains. This fluorescence microscopy image shows PAVE1, in green, which defines the subdomain of the cell posterior. TbAIR9, in magenta, is responsible for maintaining the boundaries of these subdomains. The maintenance of these subdomains is critical for the preservation of cell shape and viability. Sinclair et al.

Image Credit: Sinclair AN, 2021