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Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques

In Mycobacterium tuberculosis-infected macaques, lymph nodes are the second most commonly infected anatomic sites after the lungs. This image shows the architecture and organization of a thoracic lymph node before M. tuberculosis infection. Once infected, granulomas form and disrupt the lymph node structure and this is associated with higher bacterial burden. Flynn et al.

Image Credit: Edwin C. Klein, University of Pittsburg (2018)