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Reversible structural changes in murine norovirus

The capsid structure of murine noroviruses changes in response to aqueous conditions. By twisting the flexible hinge connecting two domains, the protruding (P) domain reversibly rises off the shell (S) domain in solutions of higher pH, but rests on the S domain in solutions of lower pH. Metal ions help to stabilize the resting conformation in this process. This image shows the two structures of the norovirus reconstructed by cryo-electron microscopy and the morphology of the resting or rising P domains on the S domain. Song et al.

Image Credit: Song C, Murata K (2020)