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Table of Contents

November 2015

Mixed primary cultures from BALB/c mice brain infected with HCoV-OC43 (rOC/SG758R). Viral spreading was evaluated at 24 hours post-infection. Neurons were stained for microtubule-associated protein 2 (MAP2) (green) and the HCoV-OC43 S viral glycoprotein (red). Nuclei were stained in blue with DAPI. Magnification 200x. Talbot et al.

Image Credit: Talbot et al.

Opinion

Emergence of Pathogenicity in Lagoviruses: Evolution from Pre-existing Nonpathogenic Strains or through a Species Jump?

Pedro José Esteves, Joana Abrantes, Stéphane Bertagnoli, Patrizia Cavadini, Dolores Gavier-Widén, Jean-Sébastien Guitton, Antonio Lavazza, Evelyne Lemaitre, Jérôme Letty, Ana Margarida Lopes, Aleksija S. Neimanis, Nathalie Ruvoën-Clouet, Jacques Le Pendu, Stéphane Marchandeau, Ghislaine Le Gall-Reculé

Pearls

Worse Comes to Worst: Bananas and Panama Disease—When Plant and Pathogen Clones Meet

Nadia Ordonez, Michael F. Seidl, Cees Waalwijk, André Drenth, Andrzej Kilian, Bart P. H. J. Thomma, Randy C. Ploetz, Gert H. J. Kema

50 Years of Emmonsia Disease in Humans: The Dramatic Emergence of a Cluster of Novel Fungal Pathogens

Ilan S. Schwartz, Chris Kenyon, Peiying Feng, Nelesh P. Govender, Karolina Dukik, Lynne Sigler, Yanping Jiang, J. Benjamin Stielow, José F. Muñoz, Christina A. Cuomo, Alfred Botha, Alberto M. Stchigel, G. Sybren de Hoog

Parasite Glycobiology: A Bittersweet Symphony

Joao A. Rodrigues, Alvaro Acosta-Serrano, Markus Aebi, Michael A. J. Ferguson, Françoise H. Routier, Irene Schiller, Simão Soares, Daniel Spencer, Alexander Titz, Iain B. H. Wilson, Luis Izquierdo

Leptospira and Bats: Story of an Emerging Friendship

Muriel Dietrich, Kristin Mühldorfer, Pablo Tortosa, Wanda Markotter

Five Questions about Mycoviruses

Moonil Son, Jisuk Yu, Kook-Hyung Kim

Review

Ebolavirus Evolution: Past and Present

Marc-Antoine de La Vega, Derek Stein, Gary P Kobinger

Research Matters

Research Articles

Increased Susceptibility of Humanized NSG Mice to Panton-Valentine Leukocidin and Staphylococcus aureus Skin Infection

Ching Wen Tseng, Juan Carlos Biancotti, Bethany L. Berg, David Gate, Stacey L. Kolar, Sabrina Müller, Maria D. Rodriguez, Kavon Rezai-Zadeh, Xuemo Fan, David O. Beenhouwer, Terrence Town, George Y. Liu

The Transcription and Translation Landscapes during Human Cytomegalovirus Infection Reveal Novel Host-Pathogen Interactions

Osnat Tirosh, Yifat Cohen, Alina Shitrit, Odem Shani, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Gilgi Friedlander, Marvin Tanenbaum, Noam Stern-Ginossar

Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus

Silke Bender, Antje Reuter, Florian Eberle, Evelyne Einhorn, Marco Binder, Ralf Bartenschlager

Structural Insight into Archaic and Alternative Chaperone-Usher Pathways Reveals a Novel Mechanism of Pilus Biogenesis

Natalia Pakharukova, James A. Garnett, Minna Tuittila, Sari Paavilainen, Mamou Diallo, Yingqi Xu, Steve J. Matthews, Anton V. Zavialov

Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection

Rami Sommerstein, Lukas Flatz, Melissa M. Remy, Pauline Malinge, Giovanni Magistrelli, Nicolas Fischer, Mehmet Sahin, Andreas Bergthaler, Sebastien Igonet, Jan ter Meulen, Dorothée Rigo, Paolo Meda, Nadia Rabah, Bruno Coutard, Thomas A. Bowden, Paul-Henri Lambert, Claire-Anne Siegrist, Daniel D. Pinschewer

The N-terminal Helical Region of the Hepatitis C Virus p7 Ion Channel Protein Is Critical for Infectious Virus Production

Margaret A. Scull, William M. Schneider, Brenna R. Flatley, Robert Hayden, Canny Fung, Christopher T. Jones, Marieke van de Belt, François Penin, Charles M. Rice

Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation

Sang Hu Kim, Shawn T. Clark, Anuradha Surendra, Julia K. Copeland, Pauline W. Wang, Ron Ammar, Cathy Collins, D. Elizabeth Tullis, Corey Nislow, David M. Hwang, David S. Guttman, Leah E. Cowen

Non-Human Primates Harbor Diverse Mammalian and Avian Astroviruses Including Those Associated with Human Infections

Erik A Karlsson, Christopher T Small, Pamela Freiden, MM Feeroz, Frederick A Matsen IV, Sorn San, M Kamrul Hasan, David Wang, Lisa Jones-Engel, Stacey Schultz-Cherry

Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes

Magali Roques, Richard J. Wall, Alexander P. Douglass, Abhinay Ramaprasad, David J. P. Ferguson, Mbinda L. Kaindama, Lorenzo Brusini, Nimitray Joshi, Zineb Rchiad, Declan Brady, David S. Guttery, Sally P. Wheatley, Hiroyuki Yamano, Anthony A. Holder, Arnab Pain, Bill Wickstead, Rita Tewari

PML/TRIM19-Dependent Inhibition of Retroviral Reverse-Transcription by Daxx

Jacques Dutrieux, Ghizlane Maarifi, Débora M. Portilho, Nathalie J. Arhel, Mounira K. Chelbi-Alix, Sébastien Nisole

Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria

Tovah N. Shaw, Phillip J. Stewart-Hutchinson, Patrick Strangward, Durga B. Dandamudi, Jonathan A. Coles, Ana Villegas-Mendez, Julio Gallego-Delgado, Nico van Rooijen, Egor Zindy, Ana Rodriguez, James M. Brewer, Kevin N. Couper, Michael L. Dustin

Diversity of Mycobacterium tuberculosis across Evolutionary Scales

Mary B. O’Neill, Tatum D. Mortimer, Caitlin S. Pepperell

RNA-seq Brings New Insights to the Intra-Macrophage Transcriptome of Salmonella Typhimurium

Shabarinath Srikumar, Carsten Kröger, Magali Hébrard, Aoife Colgan, Siân V. Owen, Sathesh K. Sivasankaran, Andrew D. S. Cameron, Karsten Hokamp, Jay C. D. Hinton

Interferon-γ Inhibits Ebola Virus Infection

Bethany A. Rhein, Linda S. Powers, Kai Rogers, Manu Anantpadma, Brajesh K. Singh, Yasuteru Sakurai, Thomas Bair, Catherine Miller-Hunt, Patrick Sinn, Robert A. Davey, Martha M. Monick, Wendy Maury

Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production via Interaction with the Structural Proteins

Pietro Scaturro, Mirko Cortese, Laurent Chatel-Chaix, Wolfgang Fischl, Ralf Bartenschlager

An O-Methyltransferase Is Required for Infection of Tick Cells by Anaplasma phagocytophilum

Adela S. Oliva Chávez, James W. Fairman, Roderick F. Felsheim, Curtis M. Nelson, Michael J. Herron, LeeAnn Higgins, Nicole Y. Burkhardt, Jonathan D. Oliver, Todd W. Markowski, Timothy J. Kurtti, Thomas E. Edwards, Ulrike G. Munderloh

Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Induces the Oncogenic miR-17-92 Cluster and Down-Regulates TGF-β Signaling

Hong Seok Choi, Vaibhav Jain, Brian Krueger, Vickie Marshall, Chang Hee Kim, Joanna L. Shisler, Denise Whitby, Rolf Renne

Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egress

Rajshekhar Y. Gaji, Derrick E. Johnson, Moritz Treeck, Mu Wang, Andy Hudmon, Gustavo Arrizabalaga

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection

Aisling F. Brown, Alison G. Murphy, Stephen J. Lalor, John M. Leech, Kate M. O’Keeffe, Micheál Mac Aogáin, Dara P. O’Halloran, Keenan A. Lacey, Mehri Tavakol, Claire H. Hearnden, Deirdre Fitzgerald-Hughes, Hilary Humphreys, Jérôme P. Fennell, Willem J. van Wamel, Timothy J. Foster, Joan A. Geoghegan, Ed C. Lavelle, Thomas R. Rogers, Rachel M. McLoughlin

Targeting HIV Reservoir in Infected CD4 T Cells by Dual-Affinity Re-targeting Molecules (DARTs) that Bind HIV Envelope and Recruit Cytotoxic T Cells

Derek D. Sloan, Chia-Ying Kao Lam, Alivelu Irrinki, Liqin Liu, Angela Tsai, Craig S. Pace, Jasmine Kaur, Jeffrey P. Murry, Mini Balakrishnan, Paul A. Moore, Syd Johnson, Jeffrey L. Nordstrom, Tomas Cihlar, Scott Koenig

Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers

Takushi Nomura, Hiroyuki Yamamoto, Hiroshi Ishii, Hirofumi Akari, Taeko K. Naruse, Akinori Kimura, Tetsuro Matano

Transcription Factor SomA Is Required for Adhesion, Development and Virulence of the Human Pathogen Aspergillus fumigatus

Chi-Jan Lin, Christoph Sasse, Jennifer Gerke, Oliver Valerius, Henriette Irmer, Holm Frauendorf, Thorsten Heinekamp, Maria Straßburger, Van Tuan Tran, Britta Herzog, Susanna A. Braus-Stromeyer, Gerhard H. Braus

Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms

Michael S. Harper, Kejun Guo, Kathrin Gibbert, Eric J. Lee, Stephanie M. Dillon, Bradley S. Barrett, Martin D. McCarter, Kim J. Hasenkrug, Ulf Dittmer, Cara C. Wilson, Mario L. Santiago