Mixed primary cultures from BALB/c mice brain infected with HCoV-OC43 (rOC/SG758R). Viral spreading was evaluated at 24 hours post-infection. Neurons were stained for microtubule-associated protein 2 (MAP2) (green) and the HCoV-OC43 S viral glycoprotein (red). Nuclei were stained in blue with DAPI. Magnification 200x. Talbot et al.
Image Credit: Talbot et al.
Opinion
Emergence of Pathogenicity in Lagoviruses: Evolution from Pre-existing Nonpathogenic Strains or through a Species Jump?
PLOS Pathogens: published November 5, 2015 | https://doi.org/10.1371/journal.ppat.1005087
Pearls
Worse Comes to Worst: Bananas and Panama Disease—When Plant and Pathogen Clones Meet
PLOS Pathogens: published November 19, 2015 | https://doi.org/10.1371/journal.ppat.1005197
50 Years of Emmonsia Disease in Humans: The Dramatic Emergence of a Cluster of Novel Fungal Pathogens
PLOS Pathogens: published November 19, 2015 | https://doi.org/10.1371/journal.ppat.1005198
Parasite Glycobiology: A Bittersweet Symphony
PLOS Pathogens: published November 12, 2015 | https://doi.org/10.1371/journal.ppat.1005169
Leptospira and Bats: Story of an Emerging Friendship
PLOS Pathogens: published November 12, 2015 | https://doi.org/10.1371/journal.ppat.1005176
Five Questions about Mycoviruses
PLOS Pathogens: published November 5, 2015 | https://doi.org/10.1371/journal.ppat.1005172
Review
Ebolavirus Evolution: Past and Present
PLOS Pathogens: published November 12, 2015 | https://doi.org/10.1371/journal.ppat.1005221
Research Matters
On the Discovery of TOR As the Target of Rapamycin
PLOS Pathogens: published November 5, 2015 | https://doi.org/10.1371/journal.ppat.1005245
Research Articles
Distinct Upstream Role of Type I IFN Signaling in Hematopoietic Stem Cell-Derived and Epithelial Resident Cells for Concerted Recruitment of Ly-6Chi Monocytes and NK Cells via CCL2-CCL3 Cascade
PLOS Pathogens: published November 30, 2015 | https://doi.org/10.1371/journal.ppat.1005256
Increased Susceptibility of Humanized NSG Mice to Panton-Valentine Leukocidin and Staphylococcus aureus Skin Infection
PLOS Pathogens: published November 30, 2015 | https://doi.org/10.1371/journal.ppat.1005292
The Transcription and Translation Landscapes during Human Cytomegalovirus Infection Reveal Novel Host-Pathogen Interactions
PLOS Pathogens: published November 24, 2015 | https://doi.org/10.1371/journal.ppat.1005288
Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus
PLOS Pathogens: published November 20, 2015 | https://doi.org/10.1371/journal.ppat.1005264
Structural Insight into Archaic and Alternative Chaperone-Usher Pathways Reveals a Novel Mechanism of Pilus Biogenesis
PLOS Pathogens: published November 20, 2015 | https://doi.org/10.1371/journal.ppat.1005269
Hsp70 Isoforms Are Essential for the Formation of Kaposi’s Sarcoma-Associated Herpesvirus Replication and Transcription Compartments
PLOS Pathogens: published November 20, 2015 | https://doi.org/10.1371/journal.ppat.1005274
Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection
PLOS Pathogens: published November 20, 2015 | https://doi.org/10.1371/journal.ppat.1005276
The N-terminal Helical Region of the Hepatitis C Virus p7 Ion Channel Protein Is Critical for Infectious Virus Production
PLOS Pathogens: published November 20, 2015 | https://doi.org/10.1371/journal.ppat.1005297
Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation
PLOS Pathogens: published November 20, 2015 | https://doi.org/10.1371/journal.ppat.1005308
Infection-Induced Retrotransposon-Derived Noncoding RNAs Enhance Herpesviral Gene Expression via the NF-κB Pathway
PLOS Pathogens: published November 19, 2015 | https://doi.org/10.1371/journal.ppat.1005260
Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation
PLOS Pathogens: published November 17, 2015 | https://doi.org/10.1371/journal.ppat.1005284
Non-Human Primates Harbor Diverse Mammalian and Avian Astroviruses Including Those Associated with Human Infections
PLOS Pathogens: published November 16, 2015 | https://doi.org/10.1371/journal.ppat.1005225
Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes
PLOS Pathogens: published November 13, 2015 | https://doi.org/10.1371/journal.ppat.1005273
Ethanolamine Signaling Promotes Salmonella Niche Recognition and Adaptation during Infection
PLOS Pathogens: published November 13, 2015 | https://doi.org/10.1371/journal.ppat.1005278
Related Articles
PML/TRIM19-Dependent Inhibition of Retroviral Reverse-Transcription by Daxx
PLOS Pathogens: published November 13, 2015 | https://doi.org/10.1371/journal.ppat.1005280
Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria
PLOS Pathogens: published November 12, 2015 | https://doi.org/10.1371/journal.ppat.1005210
Cryptosporidium Lactate Dehydrogenase Is Associated with the Parasitophorous Vacuole Membrane and Is a Potential Target for Developing Therapeutics
PLOS Pathogens: published November 12, 2015 | https://doi.org/10.1371/journal.ppat.1005250
Diversity of Mycobacterium tuberculosis across Evolutionary Scales
PLOS Pathogens: published November 12, 2015 | https://doi.org/10.1371/journal.ppat.1005257
RNA-seq Brings New Insights to the Intra-Macrophage Transcriptome of Salmonella Typhimurium
PLOS Pathogens: published November 12, 2015 | https://doi.org/10.1371/journal.ppat.1005262
Interferon-γ Inhibits Ebola Virus Infection
PLOS Pathogens: published November 12, 2015 | https://doi.org/10.1371/journal.ppat.1005263
Evolution and Emergence of Enteroviruses through Intra- and Inter-species Recombination: Plasticity and Phenotypic Impact of Modular Genetic Exchanges in the 5’ Untranslated Region
PLOS Pathogens: published November 12, 2015 | https://doi.org/10.1371/journal.ppat.1005266
Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production via Interaction with the Structural Proteins
PLOS Pathogens: published November 12, 2015 | https://doi.org/10.1371/journal.ppat.1005277
Cross-Species Transmission and Differential Fate of an Endogenous Retrovirus in Three Mammal Lineages
PLOS Pathogens: published November 12, 2015 | https://doi.org/10.1371/journal.ppat.1005279
Host and Symbiont Jointly Control Gut Microbiota during Complete Metamorphosis
PLOS Pathogens: published November 6, 2015 | https://doi.org/10.1371/journal.ppat.1005246
An O-Methyltransferase Is Required for Infection of Tick Cells by Anaplasma phagocytophilum
PLOS Pathogens: published November 6, 2015 | https://doi.org/10.1371/journal.ppat.1005248
Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Induces the Oncogenic miR-17-92 Cluster and Down-Regulates TGF-β Signaling
PLOS Pathogens: published November 6, 2015 | https://doi.org/10.1371/journal.ppat.1005255
Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System
PLOS Pathogens: published November 6, 2015 | https://doi.org/10.1371/journal.ppat.1005261
Related Articles
Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egress
PLOS Pathogens: published November 6, 2015 | https://doi.org/10.1371/journal.ppat.1005268
Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection
PLOS Pathogens: published November 5, 2015 | https://doi.org/10.1371/journal.ppat.1005226
Targeting HIV Reservoir in Infected CD4 T Cells by Dual-Affinity Re-targeting Molecules (DARTs) that Bind HIV Envelope and Recruit Cytotoxic T Cells
PLOS Pathogens: published November 5, 2015 | https://doi.org/10.1371/journal.ppat.1005233
Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers
PLOS Pathogens: published November 4, 2015 | https://doi.org/10.1371/journal.ppat.1005247
Transcription Factor SomA Is Required for Adhesion, Development and Virulence of the Human Pathogen Aspergillus fumigatus
PLOS Pathogens: published November 3, 2015 | https://doi.org/10.1371/journal.ppat.1005205
Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms
PLOS Pathogens: published November 3, 2015 | https://doi.org/10.1371/journal.ppat.1005254