Table of Contents

May 2013

The early-medieval cemetery in Aschheim-Bajuwarenring, Upper Bavaria, Germany, consists of more than 430 graves with a large number of multiple burial sites (triple graves). Remains of two hand-holding women (green and blue) with a child in between (red), dated to the 6th century A. D. The agent of the plague, Yersinia pestis, was detected and characterized from tooth material of the blue colored skeleton. See Harbeck et al.

Image Credit: H.P. Volpert


Behind Closed Membranes: The Secret Lives of Picornaviruses?

Alexsia L. Richards, William T. Jackson


Hemoglobinopathies: Slicing the Gordian Knot of Plasmodium falciparum Malaria Pathogenesis

Steve M. Taylor, Carla Cerami, Rick M. Fairhurst

Volatile Metabolites of Pathogens: A Systematic Review

Lieuwe D. J. Bos, Peter J. Sterk, Marcus J. Schultz

Research Articles

Membrane Assembly during the Infection Cycle of the Giant Mimivirus

Yael Mutsafi, Eyal Shimoni, Amir Shimon, Abraham Minsky

Antibody Quality and Protection from Lethal Ebola Virus Challenge in Nonhuman Primates Immunized with Rabies Virus Based Bivalent Vaccine

Joseph E. Blaney, Andrea Marzi, Mallory Willet, Amy B. Papaneri, Christoph Wirblich, Friederike Feldmann, Michael Holbrook, Peter Jahrling, Heinz Feldmann, Matthias J. Schnell

Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

Julie L. McAuley, Michelle D. Tate, Charley J. MacKenzie-Kludas, Anita Pinar, Weiguang Zeng, Andrea Stutz, Eicke Latz, Lorena E. Brown, Ashley Mansell

Identification of a Functional Type VI Secretion System in Campylobacter jejuni Conferring Capsule Polysaccharide Sensitive Cytotoxicity

Nancy M. C. Bleumink-Pluym, Lieke B. van Alphen, Lieneke I. Bouwman, Marc M. S. M. Wösten, Jos P. M. van Putten

Type I Interferon Programs Innate Myeloid Dynamics and Gene Expression in the Virally Infected Nervous System

Debasis Nayak, Kory R. Johnson, Sara Heydari, Theodore L. Roth, Bernd H. Zinselmeyer, Dorian B. McGavern

Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay

Gregory M. Laird, Evelyn E. Eisele, S. Alireza Rabi, Jun Lai, Stanley Chioma, Joel N. Blankson, Janet D. Siliciano, Robert F. Siliciano

Prolonged Influenza Virus Shedding and Emergence of Antiviral Resistance in Immunocompromised Patients and Ferrets

Erhard van der Vries, Koert J. Stittelaar, Geert van Amerongen, Edwin J. B. Veldhuis Kroeze, Leon de Waal, Pieter L. A. Fraaij, Roland J. Meesters, Theo M. Luider, Bart van der Nagel, Birgit Koch, Arnold G. Vulto, Martin Schutten, Albert D. M. E. Osterhaus

Class A Scavenger Receptor 1 (MSR1) Restricts Hepatitis C Virus Replication by Mediating Toll-like Receptor 3 Recognition of Viral RNAs Produced in Neighboring Cells

Hiromichi Dansako, Daisuke Yamane, Christoph Welsch, David R. McGivern, Fengyu Hu, Nobuyuki Kato, Stanley M. Lemon

Global Organization of a Positive-strand RNA Virus Genome

Baodong Wu, Jörg Grigull, Moriam O. Ore, Sylvie Morin, K. Andrew White

Pilus Phase Variation Switches Gonococcal Adherence to Invasion by Caveolin-1-Dependent Host Cell Signaling

Michaela Faulstich, Jan-Peter Böttcher, Thomas F. Meyer, Martin Fraunholz, Thomas Rudel

Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA Amplifications

Jennifer L. Guler, Daniel L. Freeman, Vida Ahyong, Rapatbhorn Patrapuvich, John White, Ramesh Gujjar, Margaret A. Phillips, Joseph DeRisi, Pradipsinh K. Rathod

Increase in Gut Microbiota after Immune Suppression in Baculovirus-infected Larvae

Agata K. Jakubowska, Heiko Vogel, Salvador Herrero

Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion

Stefanie Ameres, Josef Mautner, Fabian Schlott, Michael Neuenhahn, Dirk H. Busch, Bodo Plachter, Andreas Moosmann

Human Papillomavirus (HPV) Upregulates the Cellular Deubiquitinase UCHL1 to Suppress the Keratinocyte's Innate Immune Response

Rezaul Karim, Bart Tummers, Craig Meyers, Jennifer L. Biryukov, Samina Alam, Claude Backendorf, Veena Jha, Rienk Offringa, Gert-Jan B. van Ommen, Cornelis J. M. Melief, Daniele Guardavaccaro, Judith M. Boer, Sjoerd H. van der Burg

Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175

Edwin Chen, May M. Paing, Nichole Salinas, B. Kim Lee Sim, Niraj H. Tolia

Saturated Very Long Chain Fatty Acids Are Required for the Production of Infectious Human Cytomegalovirus Progeny

Emre Koyuncu, John G. Purdy, Joshua D. Rabinowitz, Thomas Shenk

Abortive Lytic Reactivation of KSHV in CBF1/CSL Deficient Human B Cell Lines

Barbara A. Scholz, Marie L. Harth-Hertle, Georg Malterer, Juergen Haas, Joachim Ellwart, Thomas F. Schulz, Bettina Kempkes

Proving Lipid Rafts Exist: Membrane Domains in the Prokaryote Borrelia burgdorferi Have the Same Properties as Eukaryotic Lipid Rafts

Timothy J. LaRocca, Priyadarshini Pathak, Salvatore Chiantia, Alvaro Toledo, John R. Silvius, Jorge L. Benach, Erwin London

Uracil DNA Glycosylase Counteracts APOBEC3G-Induced Hypermutation of Hepatitis B Viral Genomes: Excision Repair of Covalently Closed Circular DNA

Kouichi Kitamura, Zhe Wang, Sajeda Chowdhury, Miyuki Simadu, Miki Koura, Masamichi Muramatsu

IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection

Iwana Schmitz, Christoph Schneider, Anja Fröhlich, Helge Frebel, Daniel Christ, Warren J. Leonard, Tim Sparwasser, Annette Oxenius, Stefan Freigang, Manfred Kopf

Structural Basis of HCV Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization Escape

Thomas Krey, Annalisa Meola, Zhen-yong Keck, Laurence Damier-Piolle, Steven K. H. Foung, Felix A. Rey

Identification of Fibroblast Growth Factor Receptor 3 (FGFR3) as a Protein Receptor for Botulinum Neurotoxin Serotype A (BoNT/A)

Birgitte P. S. Jacky, Patton E. Garay, Jérôme Dupuy, Jeremy B. Nelson, Brian Cai, Yanira Molina, Joanne Wang, Lance E. Steward, Ron S. Broide, Joseph Francis, K. Roger Aoki, Raymond C. Stevens, Ester Fernández-Salas

Orthobunyavirus Ultrastructure and the Curious Tripodal Glycoprotein Spike

Thomas A. Bowden, David Bitto, Angela McLees, Christelle Yeromonahos, Richard M. Elliott, Juha T. Huiskonen

Dual Pili Post-translational Modifications Synergize to Mediate Meningococcal Adherence to Platelet Activating Factor Receptor on Human Airway Cells

Freda E. C. Jen, Matthew J. Warren, Benjamin L. Schulz, Peter M. Power, W. Edward Swords, Jeffery N. Weiser, Michael A. Apicella, Jennifer L. Edwards, Michael P. Jennings

Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidD

Yang Chen, Igor Tascón, M. Ramona Neunuebel, Chiara Pallara, Jacqueline Brady, Lisa N. Kinch, Juan Fernández-Recio, Adriana L. Rojas, Matthias P. Machner, Aitor Hierro

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