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Table of Contents: May 2015

Human malaria parasite species were originally acquired from other primate hosts and subsequently became endemic, then spread throughout large parts of the world. A major zoonosis is now occurring with Plasmodium knowlesi from macaques in Southeast Asia, with a recent acceleration in numbers of reported cases particularly in Malaysia. Divis et al.

Image Credit: Balbir Singh

Opinion

Pearls

The Role of Horizontal Gene Transfer in the Evolution of the Oomycetes

Fiona Savory, Guy Leonard, Thomas A. Richards

Advances and Challenges in Computational Prediction of Effectors from Plant Pathogenic Fungi

Jana Sperschneider, Peter N. Dodds, Donald M. Gardiner, John M. Manners, Karam B. Singh, Jennifer M. Taylor

Investigating Fungal Outbreaks in the 21st Century

Anastasia P. Litvintseva, Mary E. Brandt, Rajal K. Mody, Shawn R. Lockhart

Dust Devil: The Life and Times of the Fungus That Causes Valley Fever

Eric R. G. Lewis, Jolene R. Bowers, Bridget M. Barker

Systems Biology for Biologists

Rachel A. Hillmer

Remembering Mumps

Donald R. Latner, Carole J. Hickman

Review

Intestinal Colonization Dynamics of Vibrio cholerae

Salvador Almagro-Moreno, Kali Pruss, Ronald K. Taylor

Research Articles

The EBNA-2 N-Terminal Transactivation Domain Folds into a Dimeric Structure Required for Target Gene Activation

Anders Friberg, Sybille Thumann, Janosch Hennig, Peijian Zou, Elfriede Nössner, Paul D. Ling, Michael Sattler, Bettina Kempkes

Evidence for a Novel Mechanism of Influenza Virus-Induced Type I Interferon Expression by a Defective RNA-Encoded Protein

Yvonne Boergeling, Timofey S. Rozhdestvensky, Mirco Schmolke, Patricia Resa-Infante, Thomas Robeck, Gerrit Randau, Thorsten Wolff, Gülsah Gabriel, Jürgen Brosius, Stephan Ludwig

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

Ema T. Crooks, Tommy Tong, Bimal Chakrabarti, Kristin Narayan, Ivelin S. Georgiev, Sergey Menis, Xiaoxing Huang, Daniel Kulp, Keiko Osawa, Janelle Muranaka, Guillaume Stewart-Jones, Joanne Destefano, Sijy O’Dell, Celia LaBranche, James E. Robinson, David C. Montefiori, Krisha McKee, Sean X. Du, Nicole Doria-Rose, Peter D. Kwong, John R. Mascola, Ping Zhu, William R. Schief, Richard T. Wyatt, Robert G. Whalen, James M. Binley

TNF-α Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism

Jiyoung Lee, Yongjun Tian, Stephanie Tze Chan, Ja Yeon Kim, Cecilia Cho, Jing-hsiung James Ou

Phospholipase D1 Couples CD4+ T Cell Activation to c-Myc-Dependent Deoxyribonucleotide Pool Expansion and HIV-1 Replication

Harry E. Taylor, Glenn E. Simmons Jr, Thomas P. Mathews, Atanu K. Khatua, Waldemar Popik, Craig W. Lindsley, Richard T. D’Aquila, H. Alex Brown

Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages

Yannick Morias, Chloé Abels, Damya Laoui, Eva Van Overmeire, Martin Guilliams, Elio Schouppe, Frank Tacke, Carlie J. deVries, Patrick De Baetselier, Alain Beschin

Paradoxical Immune Responses in Non-HIV Cryptococcal Meningitis

Anil A. Panackal, Simone C. Wuest, Yen-Chih Lin, Tianxia Wu, Nannan Zhang, Peter Kosa, Mika Komori, Andrew Blake, Sarah K. Browne, Lindsey B. Rosen, Ferry Hagen, Jacques Meis, Stuart M. Levitz, Martha Quezado, Dima Hammoud, John E. Bennett, Bibi Bielekova, Peter R. Williamson

Admixture in Humans of Two Divergent Plasmodium knowlesi Populations Associated with Different Macaque Host Species

Paul C. S. Divis, Balbir Singh, Fread Anderios, Shamilah Hisam, Asmad Matusop, Clemens H. Kocken, Samuel A. Assefa, Craig W. Duffy, David J. Conway

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Phosphatidic Acid Produced by Phospholipase D Promotes RNA Replication of a Plant RNA Virus

Kiwamu Hyodo, Takako Taniguchi, Yuki Manabe, Masanori Kaido, Kazuyuki Mise, Tatsuya Sugawara, Hisaaki Taniguchi, Tetsuro Okuno

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion

Benjamin P. Hurrell, Steffen Schuster, Eva Grün, Manuel Coutaz, Roderick A. Williams, Werner Held, Bernard Malissen, Marie Malissen, Shida Yousefi, Hans-Uwe Simon, Andreas J. Müller, Fabienne Tacchini-Cottier

Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-Family Transcription Factor

Izumi Kaneko, Shiroh Iwanaga, Tomomi Kato, Issei Kobayashi, Masao Yuda

Activation of Salmonella Typhi-Specific Regulatory T Cells in Typhoid Disease in a Wild-Type S. Typhi Challenge Model

Monica A. McArthur, Stephanie Fresnay, Laurence S. Magder, Thomas C. Darton, Claire Jones, Claire S. Waddington, Christoph J. Blohmke, Gordon Dougan, Brian Angus, Myron M. Levine, Andrew J. Pollard, Marcelo B. Sztein

L-Rhamnosylation of Listeria monocytogenes Wall Teichoic Acids Promotes Resistance to Antimicrobial Peptides by Delaying Interaction with the Membrane

Filipe Carvalho, Magda L. Atilano, Rita Pombinho, Gonçalo Covas, Richard L. Gallo, Sérgio R. Filipe, Sandra Sousa, Didier Cabanes

Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity

Caline G. Matar, Neil R. Anthony, Brigid M. O’Flaherty, Nathan T. Jacobs, Lalita Priyamvada, Christian R. Engwerda, Samuel H. Speck, Tracey J. Lamb

TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation

Hannah Greenfeld, Kaoru Takasaki, Michael J. Walsh, Ina Ersing, Katharina Bernhardt, Yijie Ma, Bishi Fu, Camille W. Ashbaugh, Jackson Cabo, Sarah B. Mollo, Hufeng Zhou, Shitao Li, Benjamin E. Gewurz

Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis

Catherine W. M. Ong, Paul T. Elkington, Sara Brilha, Cesar Ugarte-Gil, Maite T. Tome-Esteban, Liku B. Tezera, Przemyslaw J. Pabisiak, Rachel C. Moores, Tarangini Sathyamoorthy, Vimal Patel, Robert H. Gilman, Joanna C. Porter, Jon S. Friedland

Influenza A Virus on Oceanic Islands: Host and Viral Diversity in Seabirds in the Western Indian Ocean

Camille Lebarbenchon, Audrey Jaeger, Chris Feare, Matthieu Bastien, Muriel Dietrich, Christine Larose, Erwan Lagadec, Gérard Rocamora, Nirmal Shah, Hervé Pascalis, Thierry Boulinier, Matthieu Le Corre, David E. Stallknecht, Koussay Dellagi

The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells

Masashi Shingai, Sarah Welbourn, Jason M. Brenchley, Priyamvada Acharya, Eri Miyagi, Ronald J. Plishka, Alicia Buckler-White, Peter D. Kwong, Yoshiaki Nishimura, Klaus Strebel, Malcolm A. Martin

Experimental Evolution of an RNA Virus in Wild Birds: Evidence for Host-Dependent Impacts on Population Structure and Competitive Fitness

Nathan D. Grubaugh, Darci R. Smith, Doug E. Brackney, Angela M. Bosco-Lauth, Joseph R. Fauver, Corey L. Campbell, Todd A. Felix, Hannah Romo, Nisha K. Duggal, Elizabeth A. Dietrich, Tyler Eike, Jennifer E. Beane, Richard A. Bowen, William C. Black, Aaron C. Brault, Gregory D. Ebel

The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin

Kareem Rashid Rumah, Yinghua Ma, Jennifer R. Linden, Myat Lin Oo, Josef Anrather, Nicole Schaeren-Wiemers, Miguel A. Alonso, Vincent A. Fischetti, Mark S. McClain, Timothy Vartanian

Widespread Recombination, Reassortment, and Transmission of Unbalanced Compound Viral Genotypes in Natural Arenavirus Infections

Mark D. Stenglein, Elliott R. Jacobson, Li-Wen Chang, Chris Sanders, Michelle G. Hawkins, David S-M. Guzman, Tracy Drazenovich, Freeland Dunker, Elizabeth K. Kamaka, Debbie Fisher, Drury R. Reavill, Linda F. Meola, Gregory Levens, Joseph L. DeRisi

FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure

Richard T. Sullivan, Charles C. Kim, Mary F. Fontana, Margaret E. Feeney, Prasanna Jagannathan, Michelle J. Boyle, Chris J. Drakeley, Isaac Ssewanyana, Felistas Nankya, Harriet Mayanja-Kizza, Grant Dorsey, Bryan Greenhouse

The Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii

Olivier Duron, Valérie Noël, Karen D. McCoy, Matteo Bonazzi, Karim Sidi-Boumedine, Olivier Morel, Fabrice Vavre, Lionel Zenner, Elsa Jourdain, Patrick Durand, Céline Arnathau, François Renaud, Jean-François Trape, Abel S. Biguezoton, Julie Cremaschi, Muriel Dietrich, Elsa Léger, Anaïs Appelgren, Marlène Dupraz, Elena Gómez-Díaz, Georges Diatta, Guiguigbaza-Kossigan Dayo, Hassane Adakal, Sébastien Zoungrana, Laurence Vial, Christine Chevillon

Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection

Yasir Alhamdi, Daniel R. Neill, Simon T. Abrams, Hesham A. Malak, Reham Yahya, Richard Barrett-Jolley, Guozheng Wang, Aras Kadioglu, Cheng-Hock Toh

Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive

David E. Sanin, Catriona T. Prendergast, Claire D. Bourke, Adrian P. Mountford

Fob1 and Fob2 Proteins Are Virulence Determinants of Rhizopus oryzae via Facilitating Iron Uptake from Ferrioxamine

Mingfu Liu, Lin Lin, Teclegiorgis Gebremariam, Guanpingsheng Luo, Christopher D. Skory, Samuel W. French, Tsui-Fen Chou, John E. Edwards Jr., Ashraf S. Ibrahim

Mechanisms of Stage-Transcending Protection Following Immunization of Mice with Late Liver Stage-Arresting Genetically Attenuated Malaria Parasites

Brandon K. Sack, Gladys J. Keitany, Ashley M. Vaughan, Jessica L. Miller, Ruobing Wang, Stefan H. I. Kappe

Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli

Dagmara I. Kisiela, Hovhannes Avagyan, Della Friend, Aachal Jalan, Shivani Gupta, Gianluca Interlandi, Yan Liu, Veronika Tchesnokova, Victoria B. Rodriguez, John P. Sumida, Roland K. Strong, Xue-Ru Wu, Wendy E. Thomas, Evgeni V. Sokurenko

Circumventing Y. pestis Virulence by Early Recruitment of Neutrophils to the Lungs during Pneumonic Plague

Yaron Vagima, Ayelet Zauberman, Yinon Levy, David Gur, Avital Tidhar, Moshe Aftalion, Avigdor Shafferman, Emanuelle Mamroud

Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms

Marieke C. Verweij, Mary Wellish, Travis Whitmer, Daniel Malouli, Martin Lapel, Stipan Jonjić, Juergen G. Haas, Victor R. DeFilippis, Ravi Mahalingam, Klaus Früh

Edin Expression in the Fat Body Is Required in the Defense Against Parasitic Wasps in Drosophila melanogaster

Leena-Maija Vanha-aho, Ines Anderl, Laura Vesala, Dan Hultmark, Susanna Valanne, Mika Rämet

A Ribonucleoprotein Complex Protects the Interleukin-6 mRNA from Degradation by Distinct Herpesviral Endonucleases

Mandy Muller, Stephanie Hutin, Oliver Marigold, Kathy H. Li, Al Burlingame, Britt A. Glaunsinger

Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway

Igor Landais, Chantel Pelton, Daniel Streblow, Victor DeFilippis, Shannon McWeeney, Jay A. Nelson

Natural Killer Cell Sensing of Infected Cells Compensates for MyD88 Deficiency but Not IFN-I Activity in Resistance to Mouse Cytomegalovirus

Clément Cocita, Rachel Guiton, Gilles Bessou, Lionel Chasson, Marilyn Boyron, Karine Crozat, Marc Dalod

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission

Ghania Ramdani, Bernina Naissant, Eloise Thompson, Florence Breil, Audrey Lorthiois, Florian Dupuy, Ross Cummings, Yoann Duffier, Yolanda Corbett, Odile Mercereau-Puijalon, Kenneth Vernick, Donatella Taramelli, David A. Baker, Gordon Langsley, Catherine Lavazec

Staphylococcus aureus Survives with a Minimal Peptidoglycan Synthesis Machine but Sacrifices Virulence and Antibiotic Resistance

Patricia Reed, Magda L. Atilano, Renato Alves, Egbert Hoiczyk, Xinwei Sher, Nathalie T. Reichmann, Pedro M. Pereira, Terry Roemer, Sérgio R. Filipe, José B. Pereira-Leal, Petros Ligoxygakis, Mariana G. Pinho

Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection

Cláudio Nunes-Alves, Matthew G. Booty, Stephen M. Carpenter, Alissa C. Rothchild, Constance J. Martin, Danielle Desjardins, Katherine Steblenko, Henrik N. Kløverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, Samuel M. Behar

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Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide

Elías Barquero-Calvo, Ricardo Mora-Cartín, Vilma Arce-Gorvel, Juana L. de Diego, Carlos Chacón-Díaz, Esteban Chaves-Olarte, Caterina Guzmán-Verri, Andre G. Buret, Jean-Pierre Gorvel, Edgardo Moreno

Discovery of a Small Non-AUG-Initiated ORF in Poleroviruses and Luteoviruses That Is Required for Long-Distance Movement

Ekaterina Smirnova, Andrew E. Firth, W. Allen Miller, Danièle Scheidecker, Véronique Brault, Catherine Reinbold, Aurélie M. Rakotondrafara, Betty Y.-W. Chung, Véronique Ziegler-Graff

An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei

Juan P. de Macêdo, Gabriela Schumann Burkard, Moritz Niemann, Michael P. Barrett, Henri Vial, Pascal Mäser, Isabel Roditi, André Schneider, Peter Bütikofer

Sequential Conformational Changes in the Morbillivirus Attachment Protein Initiate the Membrane Fusion Process

Nadine Ader-Ebert, Mojtaba Khosravi, Michael Herren, Mislay Avila, Lisa Alves, Fanny Bringolf, Claes Örvell, Johannes P. Langedijk, Andreas Zurbriggen, Richard K. Plemper, Philippe Plattet

Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype

Antonio V. Bordería, Ofer Isakov, Gonzalo Moratorio, Rasmus Henningsson, Sonia Agüera-González, Lindsey Organtini, Nina F. Gnädig, Hervé Blanc, Andrés Alcover, Susan Hafenstein, Magnus Fontes, Noam Shomron, Marco Vignuzzi

Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin

Éric Bergeron, Marko Zivcec, Ayan K. Chakrabarti, Stuart T. Nichol, César G. Albariño, Christina F. Spiropoulou