Table of Contents

February 2019

Salmonella invades intestinal HT29-MTX cells that express MUC1. A confluent monolayer of HT29-MTX cells strained with DAPI (blue) expressing transmembrane mucin MUC1 (green) was infected with Salmonella (red) from the apical surface. Salmonella attaches and invades at sites of high MUC1 expression using the giant adhesin SiiE. Li et al. (2019).

Image Credit: Xinyue Li, Department of Infectious Diseases and Immunology, Utrecht University, The Netherlands. Image was collected at the Centre for Cell Imaging (CCI) at the Faculty of Veterinary Medicine.


Casting a wider net: Immunosurveillance by nonclassical MHC molecules

M. Patricia D’Souza, Erin Adams, John D. Altman, Michael E. Birnbaum, Cesar Boggiano, Giulia Casorati, Yueh-hsiu Chien, Anthony Conley, Sidonia Barbara Guiomar Eckle, Klaus Früh, Timothy Gondré-Lewis, Namir Hassan, Huang Huang, Lakshmi Jayashankar, Anne G. Kasmar, Nina Kunwar, Judith Lavelle, David M. Lewinsohn, Branch Moody, Louis Picker, Lakshmi Ramachandra, Nilabh Shastri, Peter Parham, Andrew J. McMichael, Jonathan W. Yewdell

Research Articles

An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus

Ki Hyun Kim, Jinhee Kim, Meehyun Ko, June Young Chun, Hyori Kim, Seungtaek Kim, Ji-Young Min, Wan Beom Park, Myoung-don Oh, Junho Chung

Plant-parasitic nematodes respond to root exudate signals with host-specific gene expression patterns

Christopher A. Bell, Catherine J. Lilley, James McCarthy, Howard J. Atkinson, P. E. Urwin

Extracellular vesicles from Kaposi Sarcoma-associated herpesvirus lymphoma induce long-term endothelial cell reprogramming

Ryan P. McNamara, Pauline E. Chugh, Aubrey Bailey, Lindsey M. Costantini, Zhe Ma, Rachele Bigi, Avery Cheves, Anthony B. Eason, Justin T. Landis, Kurtis M. Host, Jie Xiong, Jack D. Griffith, Blossom Damania, Dirk P. Dittmer

Monotherapy with a low-dose lipopeptide HIV fusion inhibitor maintains long-term viral suppression in rhesus macaques

Huihui Chong, Jing Xue, Yuanmei Zhu, Zhe Cong, Ting Chen, Qiang Wei, Chuan Qin, Yuxian He

MUC1 is a receptor for the Salmonella SiiE adhesin that enables apical invasion into enterocytes

Xinyue Li, Nancy M. C. Bleumink-Pluym, Yvette M. C. A. Luijkx, Richard W. Wubbolts, Jos P. M. van Putten, Karin Strijbis

The polymeric immunoglobulin receptor-like protein from Marsupenaeus japonicus is a receptor for white spot syndrome virus infection

Guo-Juan Niu, Shuai Wang, Ji-Dong Xu, Ming-Chong Yang, Jie-Jie Sun, Zhong-Hua He, Xiao-Fan Zhao, Jin-Xing Wang

TLR4 signaling improves PD-1 blockade therapy during chronic viral infection

Yidan Wang, Young Rock Chung, Simon Eitzinger, Nicole Palacio, Shana Gregory, Mitra Bhattacharyya, Pablo Penaloza-MacMaster

Absence of adaptive evolution is the main barrier against influenza emergence in horses in Asia despite frequent virus interspecies transmission from wild birds

Henan Zhu, Batchuluun Damdinjav, Gaelle Gonzalez, Livia Victoria Patrono, Humberto Ramirez-Mendoza, Julien A. R. Amat, Joanna Crispell, Yasmin Amy Parr, Toni-ann Hammond, Enkhtuvshin Shiilegdamba, Y. H. Connie Leung, Malik Peiris, John F. Marshall, Joseph Hughes, Martin Gilbert, Pablo R. Murcia

PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

Catherine M. Buckley, Victoria L. Heath, Aurélie Guého, Cristina Bosmani, Paulina Knobloch, Phumzile Sikakana, Nicolas Personnic, Stephen K. Dove, Robert H. Michell, Roger Meier, Hubert Hilbi, Thierry Soldati, Robert H. Insall, Jason S. King

The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit

Dan F. Young, Elizabeth B. Wignall-Fleming, David C. Busse, Matthew J. Pickin, Jack Hankinson, Elizabeth M. Randall, Amy Tavendale, Andrew J. Davison, Douglas Lamont, John S. Tregoning, Steve Goodbourn, Richard E. Randall

PolyGlcNAc-containing exopolymers enable surface penetration by non-motile Enterococcus faecalis

Yusibeska Ramos, Jorge Rocha, Ana L. Hael, Jordi van Gestel, Hera Vlamakis, Colette Cywes-Bentley, Juan R. Cubillos-Ruiz, Gerald B. Pier, Michael S. Gilmore, Roberto Kolter, Diana K. Morales

TDP-43 proteinopathy in Theiler’s murine encephalomyelitis virus infection

Katsuhisa Masaki, Yoshifumi Sonobe, Ghanashyam Ghadge, Peter Pytel, Raymond P. Roos

The tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family

Kathryn E. R. Parker, Stephen J. Fairweather, Esther Rajendran, Martin Blume, Malcolm J. McConville, Stefan Bröer, Kiaran Kirk, Giel G. van Dooren

Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants

Derek W. Trobaugh, Chengqun Sun, Matthew D. Dunn, Douglas S. Reed, William B. Klimstra

Neisseria gonorrhoeae evades autophagic killing by downregulating CD46-cyt1 and remodeling lysosomes

Won J. Kim, Annette Mai, Nathan J. Weyand, Maria A. Rendón, Koenraad Van Doorslaer, Magdalene So

The transcription factor NHR-8: A new target to increase ivermectin efficacy in nematodes

Cécile Ménez, Mélanie Alberich, Elise Courtot, Fabrice Guegnard, Alexandra Blanchard, Hugo Aguilaniu, Anne Lespine

Cyclical adaptation of measles virus quasispecies to epithelial and lymphocytic cells: To V, or not to V

Ryan C. Donohue, Christian K. Pfaller, Roberto Cattaneo

A poxvirus pseudokinase represses viral DNA replication via a pathway antagonized by its paralog kinase

Annabel T. Olson, Zhigang Wang, Amber B. Rico, Matthew S. Wiebe

Identification of HIV gp41-specific antibodies that mediate killing of infected cells

Katherine L. Williams, Megan Stumpf, Nicole Elise Naiman, Shilei Ding, Meghan Garrett, Theodore Gobillot, Dani Vézina, Katharine Dusenbury, Nitya S. Ramadoss, Ryan Basom, Peter S. Kim, Andrés Finzi, Julie Overbaugh

EhFP10: A FYVE family GEF interacts with myosin IB to regulate cytoskeletal dynamics during endocytosis in Entamoeba histolytica

Gunjan Gautam, Mohammad Sabir Ali, Alok Bhattacharya, Samudrala Gourinath

Picornavirus infection induces temporal release of multiple extracellular vesicle subsets that differ in molecular composition and infectious potential

Susanne G. van der Grein, Kyra A. Y. Defourny, Huib H. Rabouw, Chenna R. Galiveti, Martijn A. Langereis, Marca H. M. Wauben, Ger J. A. Arkesteijn, Frank J. M. van Kuppeveld, Esther N. M. Nolte-‘t Hoen

Plant begomoviruses subvert ubiquitination to suppress plant defenses against insect vectors

Ping Li, Chao Liu, Wen-Hao Deng, Dan-Mei Yao, Li-Long Pan, Yun-Qin Li, Yin-Quan Liu, Yan Liang, Xue-Ping Zhou, Xiao-Wei Wang

PML nuclear body-residing proteins sequentially associate with HPV genome after infectious nuclear delivery

Lucile Guion, Malgorzata Bienkowska-Haba, Stephen DiGiuseppe, Luise Florin, Martin Sapp

Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation

Amina A. Negash, Rebecca M. Olson, Stephen Griffin, Michael Gale Jr

Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells

Jasmin Akter, David S. Khoury, Rosemary Aogo, Lianne I. M. Lansink, Arya SheelaNair, Bryce S. Thomas, Pawat Laohamonthonkul, Clara P. S. Pernold, Matthew W. A. Dixon, Megan S. F. Soon, Lily G. Fogg, Jessica A. Engel, Trish Elliott, Ismail Sebina, Kylie R. James, Deborah Cromer, Miles P. Davenport, Ashraful Haque

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection

Marion Pardons, Amy E. Baxter, Marta Massanella, Amélie Pagliuzza, Rémi Fromentin, Caroline Dufour, Louise Leyre, Jean-Pierre Routy, Daniel E. Kaufmann, Nicolas Chomont

NDRG1 facilitates the replication and persistence of Kaposi’s sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA

Fang Zhang, Deguang Liang, Xiaoxi Lin, Zhe Zou, Rui Sun, Xing Wang, Xiaozhen Liang, Kenneth M. Kaye, Ke Lan

The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection

Rui Zhang, Monica Varela, Wies Vallentgoed, Gabriel Forn-Cuni, Michiel van der Vaart, Annemarie H. Meijer

Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine

Md Niaz Rahim, Edmund G. Wee, Shihua He, Jonathan Audet, Kevin Tierney, Nathifa Moyo, Zara Hannoun, Alison Crook, Andrea Baines, Bette Korber, Xiangguo Qiu, Tomáš Hanke

Sensing of cell-associated HTLV by plasmacytoid dendritic cells is regulated by dense β-galactoside glycosylation

Sonia Assil, Nicolas Futsch, Elodie Décembre, Sandrine Alais, Antoine Gessain, François-Loïc Cosset, Renaud Mahieux, Marlène Dreux, Hélène Dutartre


Correction: Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1

Romel D. Mackelprang, Michael J. Bamshad, Jessica X. Chong, Xuanlin Hou, Kati J. Buckingham, Kathryn Shively, Guy deBruyn, Nelly R. Mugo, James I. Mullins, M. Juliana McElrath, Jared M. Baeten, Connie Celum, Mary J. Emond, Jairam R. Lingappa, for the Partners in Prevention HSV/HIV Transmission Study and the Partners PrEP Study Teams

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