September 2021

Aedes aegypti females either non-fed (right) or fed with blue-coloured sugar (left). The ingested sugar solution is stored in the crop, which is visible through the abdomen on the picture thanks to the blue dye, and is intermittently relocated to the gut for digestion. See Almire et al.

Image Credit: Emilie Pondeville, 2021

Opinions

What is the risk of a deadly adenovirus pandemic?

Eric J. Kremer

PLOS Pathogens: published September 2, 2021 | https://doi.org/10.1371/journal.ppat.1009814

Neutrophils and lymphopenia, an unknown axis in severe COVID-19 disease

Hernán F. Peñaloza, Janet S. Lee, Prabir Ray

PLOS Pathogens: published September 2, 2021 | https://doi.org/10.1371/journal.ppat.1009850

Pearls

From one to many: The within-host rise of viral variants

Pierre Bessière, Romain Volmer

PLOS Pathogens: published September 2, 2021 | https://doi.org/10.1371/journal.ppat.1009811

Xylella fastidiosa: A reemerging plant pathogen that threatens crops globally

Claudia Castro, Biagio DiSalvo, M. Caroline Roper

PLOS Pathogens: published September 9, 2021 | https://doi.org/10.1371/journal.ppat.1009813

Sugarcoating it: Enterococcal polysaccharides as key modulators of host–pathogen interactions

Yusibeska Ramos, Stephanie Sansone, Diana K. Morales

PLOS Pathogens: published September 9, 2021 | https://doi.org/10.1371/journal.ppat.1009822

Corallicolids: The elusive coral-infecting apicomplexans

Patrick J. Keeling, Varsha Mathur, Waldan K. Kwong

PLOS Pathogens: published September 16, 2021 | https://doi.org/10.1371/journal.ppat.1009845

Current status of therapeutic monoclonal antibodies against SARS-CoV-2

Sanjeev Kumar, Anmol Chandele, Amit Sharma

PLOS Pathogens: published September 3, 2021 | https://doi.org/10.1371/journal.ppat.1009885

Enveloped RNA virus utilization of phosphatidylserine receptors: Advantages of exploiting a conserved, widely available mechanism of entry

Dana Bohan, Wendy Maury

PLOS Pathogens: published September 23, 2021 | https://doi.org/10.1371/journal.ppat.1009899

Reviews

Biofilm regulation in Clostridioides difficile: Novel systems linked to hypervirulence

Megan G. Taggart, William J. Snelling, Patrick J. Naughton, Roberto M. La Ragione, James S. G. Dooley, Nigel G. Ternan

PLOS Pathogens: published September 9, 2021 | https://doi.org/10.1371/journal.ppat.1009817

Noncytotoxic functions of killer cell granzymes in viral infections

Lisanne C. de Jong, Sandra Crnko, Toine ten Broeke, Niels Bovenschen

PLOS Pathogens: published September 16, 2021 | https://doi.org/10.1371/journal.ppat.1009818

Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei

Nathan P. Crilly, Monica R. Mugnier

PLOS Pathogens: published September 16, 2021 | https://doi.org/10.1371/journal.ppat.1009866

Bacterial evolution during human infection: Adapt and live or adapt and die

Matthew J. Culyba, Daria Van Tyne

PLOS Pathogens: published September 9, 2021 | https://doi.org/10.1371/journal.ppat.1009872

Immunological exhaustion: How to make a disparate concept operational?

Hannah Kaminski, Maël Lemoine, Thomas Pradeu

PLOS Pathogens: published September 23, 2021 | https://doi.org/10.1371/journal.ppat.1009892

Research Articles

Interplay of Trypanosome Lytic Factor and innate immune cells in the resolution of cutaneous Leishmania infection

Jyoti Pant, Marie Samanovic, Maria T. Nelson, Mert K. Keceli, Joseph Verdi, Stephen M. Beverley, Jayne Raper

PLOS Pathogens: published September 24, 2021 | https://doi.org/10.1371/journal.ppat.1008768

Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome

Yuta Shirogane, Elsa Rousseau, Jakub Voznica, Yinghong Xiao, Weiheng Su, Adam Catching, Zachary J. Whitfield, Igor M. Rouzine, Simone Bianco, Raul Andino

PLOS Pathogens: published September 27, 2021 | https://doi.org/10.1371/journal.ppat.1009277

Rab11a mediates cell-cell spread and reassortment of influenza A virus genomes via tunneling nanotubes

Ketaki Ganti, Julianna Han, Balaji Manicassamy, Anice C. Lowen

PLOS Pathogens: published September 2, 2021 | https://doi.org/10.1371/journal.ppat.1009321

HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration

Anabel Guedán, Callum D. Donaldson, Eve R. Caroe, Ophélie Cosnefroy, Ian A. Taylor, Kate N. Bishop

PLOS Pathogens: published September 20, 2021 | https://doi.org/10.1371/journal.ppat.1009484

The late endosome-resident lipid bis(monoacylglycero)phosphate is a cofactor for Lassa virus fusion

Ruben M. Markosyan, Mariana Marin, You Zhang, Fredric S. Cohen, Gregory B. Melikyan

PLOS Pathogens: published September 7, 2021 | https://doi.org/10.1371/journal.ppat.1009488

Phagocytes produce prostaglandin E₂ in response to cytosolic Listeria monocytogenes

Courtney E. McDougal, Zachary T. Morrow, Tighe Christopher, Seonyoung Kim, Drake Carter, David M. Stevenson, Daniel Amador-Noguez, Mark J. Miller, John-Demian Sauer

PLOS Pathogens: published September 23, 2021 | https://doi.org/10.1371/journal.ppat.1009493

The small acid-soluble proteins of Clostridioides difficile are important for UV resistance and serve as a check point for sporulation

Hailee N. Nerber, Joseph A. Sorg

PLOS Pathogens: published September 8, 2021 | https://doi.org/10.1371/journal.ppat.1009516

Infection with endosymbiotic Spiroplasma disrupts tsetse (Glossina fuscipes fuscipes) metabolic and reproductive homeostasis

Jae Hak Son, Brian L. Weiss, Daniela I. Schneider, Kiswend-sida M. Dera, Fabian Gstöttenmayer, Robert Opiro, Richard Echodu, Norah P. Saarman, Geoffrey M. Attardo, Maria Onyango, Adly M. M. Abd-Alla, Serap Aksoy

PLOS Pathogens: published September 16, 2021 | https://doi.org/10.1371/journal.ppat.1009539

Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization

Safia S. Aljedani, Tyler J. Liban, Karen Tran, Ganesh Phad, Suruchi Singh, Viktoriya Dubrovskaya, Pradeepa Pushparaj, Paola Martinez-Murillo, Justas Rodarte, Alex Mileant, Vidya Mangala Prasad, Rachel Kinzelman, Sijy O’Dell, John R. Mascola, Kelly K. Lee, Gunilla B. Karlsson Hedestam, Richard T. Wyatt, Marie Pancera

PLOS Pathogens: published September 24, 2021 | https://doi.org/10.1371/journal.ppat.1009543

Characterization of changes in the hemagglutinin that accompanied the emergence of H3N2/1968 pandemic influenza viruses

Johanna West, Juliane Röder, Tatyana Matrosovich, Jana Beicht, Jan Baumann, Nancy Mounogou Kouassi, Jennifer Doedt, Nicolai Bovin, Gianpiero Zamperin, Michele Gastaldelli, Annalisa Salviato, Francesco Bonfante, Sergei Kosakovsky Pond, Sander Herfst, Ron Fouchier, Jochen Wilhelm, Hans-Dieter Klenk, Mikhail Matrosovich

PLOS Pathogens: published September 23, 2021 | https://doi.org/10.1371/journal.ppat.1009566

Biogenesis of P-TEFb in CD4⁺ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways

Uri Mbonye, Konstantin Leskov, Meenakshi Shukla, Saba Valadkhan, Jonathan Karn

PLOS Pathogens: published September 16, 2021 | https://doi.org/10.1371/journal.ppat.1009581

Phase separation of a plant virus movement protein and cellular factors support virus-host interactions

Shelby L. Brown, Dana J. Garrison, Jared P. May

PLOS Pathogens: published September 20, 2021 | https://doi.org/10.1371/journal.ppat.1009622

Cell-to-cell transmission of HSV1 in human keratinocytes in the absence of the major entry receptor, nectin1

Joanne Kite, Tiffany Russell, Juliet Jones, Gillian Elliott

PLOS Pathogens: published September 29, 2021 | https://doi.org/10.1371/journal.ppat.1009631

Teaching a new mouse old tricks: Humanized mice as an infection model for Variola virus

Christina L. Hutson, Ashley V. Kondas, Jana M. Ritter, Zachary Reed, Sharon Dietz Ostergaard, Clint N. Morgan, Nadia Gallardo-Romero, Cassandra Tansey, Matthew R. Mauldin, Johanna S. Salzer, Christine M. Hughes, Cynthia S. Goldsmith, Darin Carroll, Victoria A. Olson

PLOS Pathogens: published September 21, 2021 | https://doi.org/10.1371/journal.ppat.1009633

Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Protein co-immunization in rhesus macaques

Margherita Rosati, Mahesh Agarwal, Xintao Hu, Santhi Devasundaram, Dimitris Stellas, Bhabadeb Chowdhury, Jenifer Bear, Robert Burns, Duncan Donohue, Laurent Pessaint, Hanne Andersen, Mark G. Lewis, Evangelos Terpos, Meletios Athanasios Dimopoulos, Alexander Wlodawer, James I. Mullins, David J. Venzon, George N. Pavlakis, Barbara K. Felber

PLOS Pathogens: published September 22, 2021 | https://doi.org/10.1371/journal.ppat.1009701

Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients

Jonathan Youngs, Nicholas M. Provine, Nicholas Lim, Hannah R. Sharpe, Ali Amini, Yi-Ling Chen, Jian Luo, Matthew D. Edmans, Panagiota Zacharopoulou, Wentao Chen, Oliver Sampson, Robert Paton, William J. Hurt, David A. Duncan, Anna L. McNaughton, Vincent N. Miao, Susannah Leaver, Duncan L. A. Wyncoll, Jonathan Ball, Philip Hopkins, Oxford Immunology Network Covid-19 response T cell Consortium, Oxford Protective T cell Immunology for COVID-19 (OPTIC) Clinical team, Donal T. Skelly, Eleanor Barnes, Susanna Dunachie, Graham Ogg, Teresa Lambe, Ian Pavord, Alex K. Shalek, Craig P. Thompson, Luzheng Xue, Derek C. Macallan, Philip Goulder, Paul Klenerman, Tihana Bicanic

PLOS Pathogens: published September 16, 2021 | https://doi.org/10.1371/journal.ppat.1009804

Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells

Adam Pickard, Ben C. Calverley, Joan Chang, Richa Garva, Sara Gago, Yinhui Lu, Karl E. Kadler

PLOS Pathogens: published September 9, 2021 | https://doi.org/10.1371/journal.ppat.1009840

Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19

Janna Heide, Sophia Schulte, Matin Kohsar, Thomas Theo Brehm, Marissa Herrmann, Hendrik Karsten, Matthias Marget, Sven Peine, Alexandra M. Johansson, Alessandro Sette, Marc Lütgehetmann, William W. Kwok, John Sidney, Julian Schulze zur Wiesch

PLOS Pathogens: published September 16, 2021 | https://doi.org/10.1371/journal.ppat.1009842

Kaposi’s sarcoma-associated herpesvirus promotes mesenchymal-to-endothelial transition by resolving the bivalent chromatin of PROX1 gene

Yao Ding, Weikang Chen, Zhengzhou Lu, Yan Wang, Yan Yuan

PLOS Pathogens: published September 7, 2021 | https://doi.org/10.1371/journal.ppat.1009847

Sugar feeding protects against arboviral infection by enhancing gut immunity in the mosquito vector Aedes aegypti

Floriane Almire, Selim Terhzaz, Sandra Terry, Melanie McFarlane, Rommel J. Gestuveo, Agnieszka M. Szemiel, Margus Varjak, Alma McDonald, Alain Kohl, Emilie Pondeville

PLOS Pathogens: published September 2, 2021 | https://doi.org/10.1371/journal.ppat.1009870

T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy

Gila Lustig, Sandile Cele, Farina Karim, Anne Derache, Abigail Ngoepe, Khadija Khan, Bernadett I. Gosnell, Mahomed-Yunus S. Moosa, Ntombi Ntshuba, Suzaan Marais, Prakash M. Jeena, Katya Govender, John Adamson, Henrik Kløverpris, Ravindra K. Gupta, Rohen Harrichandparsad, Vinod B. Patel, Alex Sigal

PLOS Pathogens: published September 23, 2021 | https://doi.org/10.1371/journal.ppat.1009871

Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells

Kathrin Stelzner, Aziza Boyny, Tobias Hertlein, Aneta Sroka, Adriana Moldovan, Kerstin Paprotka, David Kessie, Helene Mehling, Jan Potempa, Knut Ohlsen, Martin J. Fraunholz, Thomas Rudel

PLOS Pathogens: published September 2, 2021 | https://doi.org/10.1371/journal.ppat.1009874

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

Martina Severa, Roberta A. Diotti, Marilena P. Etna, Fabiana Rizzo, Stefano Fiore, Daniela Ricci, Marco Iannetta, Alessandro Sinigaglia, Alessandra Lodi, Nicasio Mancini, Elena Criscuolo, Massimo Clementi, Massimo Andreoni, Stefano Balducci, Luisa Barzon, Paola Stefanelli, Nicola Clementi, Eliana M. Coccia

PLOS Pathogens: published September 2, 2021 | https://doi.org/10.1371/journal.ppat.1009878

Commensal bacteria augment Staphylococcus aureus infection by inactivation of phagocyte-derived reactive oxygen species

Josie F. Gibson, Grace R. Pidwill, Oliver T. Carnell, Bas G. J. Surewaard, Daria Shamarina, Joshua A. F. Sutton, Charlotte Jeffery, Aurélie Derré-Bobillot, Cristel Archambaud, Matthew K. Siggins, Eric J. G. Pollitt, Simon A. Johnston, Pascale Serror, Shiranee Sriskandan, Stephen A. Renshaw, Simon J. Foster

PLOS Pathogens: published September 16, 2021 | https://doi.org/10.1371/journal.ppat.1009880

Outbreaks of SARS-CoV-2 in naturally infected mink farms: Impact, transmission dynamics, genetic patterns, and environmental contamination

Serafeim C. Chaintoutis, Zoi Thomou, Evangelia Mouchtaropoulou, George Tsiolas, Taxiarchis Chassalevris, Ioanna Stylianaki, Maria Lagou, Sofia Michailidou, Evangelia Moutou, Jacobus Johannes Hendrik Koenen, Jacoba Wilhelmina Dijkshoorn, Dimitrios Paraskevis, Theofilos Poutahidis, Victoria I. Siarkou, Vana Sypsa, Anagnostis Argiriou, Paschalis Fortomaris, Chrysostomos I. Dovas

PLOS Pathogens: published September 7, 2021 | https://doi.org/10.1371/journal.ppat.1009883

A variant ECE1 allele contributes to reduced pathogenicity of Candida albicans during vulvovaginal candidiasis

Junyan Liu, Hubertine M. E. Willems, Emily A. Sansevere, Stefanie Allert, Katherine S. Barker, David J. Lowes, Andrew C. Dixson, Zhenbo Xu, Jian Miao, Christian DeJarnette, Helene Tournu, Glen E. Palmer, Jonathan P. Richardson, Francisco N. Barrera, Bernhard Hube, Julian R. Naglik, Brian M. Peters

PLOS Pathogens: published September 10, 2021 | https://doi.org/10.1371/journal.ppat.1009884

A 3,000-year-old, basal S. enterica lineage from Bronze Age Xinjiang suggests spread along the Proto-Silk Road

Xiyan Wu, Chao Ning, Felix M. Key, Aida Andrades Valtueña, Aditya Kumar Lankapalli, Shizhu Gao, Xuan Yang, Fan Zhang, Linlin Liu, Zhongzhi Nie, Jian Ma, Johannes Krause, Alexander Herbig, Yinqiu Cui

PLOS Pathogens: published September 21, 2021 | https://doi.org/10.1371/journal.ppat.1009886

Aconitate decarboxylase 1 participates in the control of pulmonary Brucella infection in mice

Aurore Demars, Armelle Vitali, Audrey Comein, Elodie Carlier, Abdulkader Azouz, Stanislas Goriely, Justine Smout, Véronique Flamand, Mégane Van Gysel, Johan Wouters, Jan Abendroth, Thomas E. Edwards, Arnaud Machelart, Eik Hoffmann, Priscille Brodin, Xavier De Bolle, Eric Muraille

PLOS Pathogens: published September 15, 2021 | https://doi.org/10.1371/journal.ppat.1009887

The opportunistic intracellular bacterial pathogen Rhodococcus equi elicits type I interferon by engaging cytosolic DNA sensing in macrophages

Krystal J. Vail, Bibiana Petri da Silveira, Samantha L. Bell, Noah D. Cohen, Angela I. Bordin, Kristin L. Patrick, Robert O. Watson

PLOS Pathogens: published September 2, 2021 | https://doi.org/10.1371/journal.ppat.1009888

Hepatitis C virus induces oxidation and degradation of apolipoprotein B to enhance lipid accumulation and promote viral production

Bei Wang, Yue Zhu, Congci Yu, Chongyang Zhang, Qing Tang, He Huang, Zhendong Zhao

PLOS Pathogens: published September 7, 2021 | https://doi.org/10.1371/journal.ppat.1009889

Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection

Qibin Geng, Wanbo Tai, Victoria K. Baxter, Juan Shi, Yushun Wan, Xiujuan Zhang, Stephanie A. Montgomery, Sharon A. Taft-Benz, Elizabeth J. Anderson, Audrey C. Knight, Kenneth H. Dinnon III, Sarah R. Leist, Ralph S. Baric, Jian Shang, Sung-Wook Hong, Aleksandra Drelich, Chien-Te K. Tseng, Marc Jenkins, Mark Heise, Lanying Du, Fang Li

PLOS Pathogens: published September 7, 2021 | https://doi.org/10.1371/journal.ppat.1009897

Ethacridine inhibits SARS-CoV-2 by inactivating viral particles

Xiaoquan Li, Peter V. Lidsky, Yinghong Xiao, Chien-Ting Wu, Miguel Garcia-Knight, Junjiao Yang, Tsuguhisa Nakayama, Jayakar V. Nayak, Peter K. Jackson, Raul Andino, Xiaokun Shu

PLOS Pathogens: published September 3, 2021 | https://doi.org/10.1371/journal.ppat.1009898

TRIM25 inhibits infectious bursal disease virus replication by targeting VP3 for ubiquitination and degradation

Suyan Wang, Mengmeng Yu, Aijing Liu, Yuanling Bao, Xiaole Qi, Li Gao, Yuntong Chen, Peng Liu, Yulong Wang, Lixiao Xing, Lingzhai Meng, Yu Zhang, Linjin Fan, Xinyi Li, Qing Pan, Yanping Zhang, Hongyu Cui, Kai Li, Changjun Liu, Xijun He, Yulong Gao, Xiaomei Wang

PLOS Pathogens: published September 13, 2021 | https://doi.org/10.1371/journal.ppat.1009900

Myeloid neddylation targets IRF7 and promotes host innate immunity against RNA viruses

Min Zhao, Yaolin Zhang, Xiqin Yang, Jiayang Jin, Zhuo Shen, Xiaoyao Feng, Tao Zou, Lijiao Deng, Daohai Cheng, Xueting Zhang, Cheng Qin, Chunxiao Niu, Zhenjie Ye, Xueying Zhang, Jia He, Chunmei Hou, Ge Li, Gencheng Han, Qianqian Cheng, Qingyang Wang, Lin Wei, Jie Dong, Jiyan Zhang

PLOS Pathogens: published September 10, 2021 | https://doi.org/10.1371/journal.ppat.1009901

The establishment of variant surface glycoprotein monoallelic expression revealed by single-cell RNA-seq of Trypanosoma brucei in the tsetse fly salivary glands

Sebastian Hutchinson, Sophie Foulon, Aline Crouzols, Roberta Menafra, Brice Rotureau, Andrew D. Griffiths, Philippe Bastin

PLOS Pathogens: published September 20, 2021 | https://doi.org/10.1371/journal.ppat.1009904

Human parainfluenza virus type 1 regulates cholesterol biosynthesis and establishes quiescent infection in human airway cells

Yuki Kurebayashi, Shringkhala Bajimaya, Masahiro Watanabe, Nicholas Lim, Michael Lutz, Megan Dunagan, Toru Takimoto

PLOS Pathogens: published September 16, 2021 | https://doi.org/10.1371/journal.ppat.1009908

Elucidating the mechanism by which synthetic helper peptides sensitize Pseudomonas aeruginosa to multiple antibiotics

Yushan Xia, Rubén Cebrián, Congjuan Xu, Anne de Jong, Weihui Wu, Oscar P. Kuipers

PLOS Pathogens: published September 3, 2021 | https://doi.org/10.1371/journal.ppat.1009909

Relationship between hemagglutinin stability and influenza virus persistence after exposure to low pH or supraphysiological heating

Guohua Yang, Chet R. Ojha, Charles J. Russell

PLOS Pathogens: published September 3, 2021 | https://doi.org/10.1371/journal.ppat.1009910

Quantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data

Gonché Danesh, Victor Virlogeux, Christophe Ramière, Caroline Charre, Laurent Cotte, Samuel Alizon

PLOS Pathogens: published September 14, 2021 | https://doi.org/10.1371/journal.ppat.1009916

The regulation landscape of MAPK signaling cascade for thwarting Bacillus thuringiensis infection in an insect host

Zhaojiang Guo, Shi Kang, Qingjun Wu, Shaoli Wang, Neil Crickmore, Xuguo Zhou, Alejandra Bravo, Mario Soberón, Youjun Zhang

PLOS Pathogens: published September 8, 2021 | https://doi.org/10.1371/journal.ppat.1009917

Histone demethylase LSD1 promotes RIG-I poly-ubiquitination and anti-viral gene expression

Qi-Xin Hu, Hui-Yi Wang, Lu Jiang, Chen-Yu Wang, Lin-Gao Ju, Yuan Zhu, Bo Zhong, Min Wu, Zhen Wang, Lian-Yun Li

PLOS Pathogens: published September 16, 2021 | https://doi.org/10.1371/journal.ppat.1009918

The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape

Charlotte Vandermeulen, Tina O’Grady, Jerome Wayet, Bartimee Galvan, Sibusiso Maseko, Majid Cherkaoui, Alice Desbuleux, Georges Coppin, Julien Olivet, Lamya Ben Ameur, Keisuke Kataoka, Seishi Ogawa, Olivier Hermine, Ambroise Marcais, Marc Thiry, Franck Mortreux, Michael A. Calderwood, Johan Van Weyenbergh, Jean-Marie Peloponese, Benoit Charloteaux, Anne Van den Broeke, David E. Hill, Marc Vidal, Franck Dequiedt, Jean-Claude Twizere

PLOS Pathogens: published September 20, 2021 | https://doi.org/10.1371/journal.ppat.1009919

Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes

Jory A. Goldsmith, Andrea M. DiVenere, Jennifer A. Maynard, Jason S. McLellan

PLOS Pathogens: published September 21, 2021 | https://doi.org/10.1371/journal.ppat.1009920

Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology

Salimata Bagayoko, Stephen Adonai Leon-Icaza, Miriam Pinilla, Audrey Hessel, Karin Santoni, David Péricat, Pierre-Jean Bordignon, Flavie Moreau, Elif Eren, Aurélien Boyancé, Emmanuelle Naser, Lise Lefèvre, Céline Berrone, Nino Iakobachvili, Arnaud Metais, Yoann Rombouts, Geanncarlo Lugo-Villarino, Agnès Coste, Ina Attrée, Dara W. Frank, Hans Clevers, Peter J. Peters, Céline Cougoule, Rémi Planès, Etienne Meunier

PLOS Pathogens: published September 13, 2021 | https://doi.org/10.1371/journal.ppat.1009927

In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2

Agnieszka M. Szemiel, Andres Merits, Richard J. Orton, Oscar A. MacLean, Rute Maria Pinto, Arthur Wickenhagen, Gauthier Lieber, Matthew L. Turnbull, Sainan Wang, Wilhelm Furnon, Nicolas M. Suarez, Daniel Mair, Ana da Silva Filipe, Brian J. Willett, Sam J. Wilson, Arvind H. Patel, Emma C. Thomson, Massimo Palmarini, Alain Kohl, Meredith E. Stewart

PLOS Pathogens: published September 17, 2021 | https://doi.org/10.1371/journal.ppat.1009929

Branched chain fatty acid synthesis drives tissue-specific innate immune response and infection dynamics of Staphylococcus aureus

Xi Chen, Wei Ping Teoh, Madison R. Stock, Zachary J. Resko, Francis Alonzo III

PLOS Pathogens: published September 8, 2021 | https://doi.org/10.1371/journal.ppat.1009930

The viral nucleocapsid protein and the human RNA-binding protein Mex3A promote translation of the Andes orthohantavirus small mRNA

Jorge Vera-Otarola, Estefania Castillo-Vargas, Jenniffer Angulo, Francisco M. Barriga, Eduard Batlle, Marcelo Lopez-Lastra

PLOS Pathogens: published September 21, 2021 | https://doi.org/10.1371/journal.ppat.1009931

The type 3 secretion system requires actin polymerization to open translocon pores

Brian C. Russo, Jeffrey K. Duncan-Lowey, Poyin Chen, Marcia B. Goldberg

PLOS Pathogens: published September 9, 2021 | https://doi.org/10.1371/journal.ppat.1009932

Trypanosoma brucei triggers a broad immune response in the adipose tissue

Henrique Machado, Tiago Bizarra-Rebelo, Mariana Costa-Sequeira, Sandra Trindade, Tânia Carvalho, Filipa Rijo-Ferreira, Barbara Rentroia-Pacheco, Karine Serre, Luisa M. Figueiredo

PLOS Pathogens: published September 15, 2021 | https://doi.org/10.1371/journal.ppat.1009933

Entamoeba histolytica activation of caspase-1 degrades cullin that attenuates NF-κB dependent signaling from macrophages

Attinder Chadha, France Moreau, Shanshan Wang, Antoine Dufour, Kris Chadee

PLOS Pathogens: published September 9, 2021 | https://doi.org/10.1371/journal.ppat.1009936

The Ebola virus soluble glycoprotein contributes to viral pathogenesis by activating the MAP kinase signaling pathway

Wakako Furuyama, Kyle Shifflett, Heinz Feldmann, Andrea Marzi

PLOS Pathogens: published September 16, 2021 | https://doi.org/10.1371/journal.ppat.1009937

PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection

Zhenyu Wang, Jing Chen, Xingchen Wu, Dan Ma, Xiaohua Zhang, Ruizhen Li, Cong Han, Haixin Liu, Xiangrui Yin, Qian Du, Dewen Tong, Yong Huang

PLOS Pathogens: published September 20, 2021 | https://doi.org/10.1371/journal.ppat.1009940

TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis

Jeffrey M. Collins, Dean P. Jones, Ashish Sharma, Manoj Khadka, Ken H. Liu, Russell R. Kempker, Brendan Prideaux, Kristal Maner-Smith, Nestani Tukvadze, N. Sarita Shah, James C. M. Brust, Rafick-Pierre Sékaly, Neel R. Gandhi, Henry M. Blumberg, Eric A. Ortlund, Thomas R. Ziegler

PLOS Pathogens: published September 24, 2021 | https://doi.org/10.1371/journal.ppat.1009941

Salmonella Typhimurium impairs glycolysis-mediated acidification of phagosomes to evade macrophage defense

Saray Gutiérrez, Julia Fischer, Raja Ganesan, Nina Judith Hos, Gökhan Cildir, Martina Wolke, Alberto Pessia, Peter Frommolt, Vincenzo Desiderio, Vidya Velagapudi, Nirmal Robinson

PLOS Pathogens: published September 23, 2021 | https://doi.org/10.1371/journal.ppat.1009943

Protective CD4⁺ Th1 cell-mediated immunity is reliant upon execution of effector function prior to the establishment of the pathogen niche

Leah S. Hohman, Zhirong Mou, Matheus B. Carneiro, Gabriel Ferland, Rachel M. Kratofil, Paul Kubes, Jude E. Uzonna, Nathan C. Peters

PLOS Pathogens: published September 20, 2021 | https://doi.org/10.1371/journal.ppat.1009944

Androgen receptor transactivates KSHV noncoding RNA PAN to promote lytic replication–mediated oncogenesis: A mechanism of sex disparity in KS

Mingzhu Ding, Jinfeng Wu, Rui Sun, Lijun Yan, Lei Bai, Jiajian Shi, Hua Feng, Yuqi Zhang, Ke Lan, Xing Wang

PLOS Pathogens: published September 20, 2021 | https://doi.org/10.1371/journal.ppat.1009947

Comparison of transcriptional profiles of Treponema pallidum during experimental infection of rabbits and in vitro culture: Highly similar, yet different

Bridget D. De Lay, Todd A. Cameron, Nicholas R. De Lay, Steven J. Norris, Diane G. Edmondson

PLOS Pathogens: published September 27, 2021 | https://doi.org/10.1371/journal.ppat.1009949

Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis

Nikhil Sharma, Chenyao Wang, Patricia Kessler, Ganes C. Sen

PLOS Pathogens: published September 30, 2021 | https://doi.org/10.1371/journal.ppat.1009950

Influenza A virus segments five and six can harbor artificial introns allowing expanded coding capacity

Heather M. Froggatt, Kaitlyn N. Burke, Ryan R. Chaparian, Hector A. Miranda, Xinyu Zhu, Benjamin S. Chambers, Nicholas S. Heaton

PLOS Pathogens: published September 27, 2021 | https://doi.org/10.1371/journal.ppat.1009951

The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection

Jinlin Li, Noemi Nagy, Jiangnan Liu, Soham Gupta, Teresa Frisan, Thomas Hennig, Donald P. Cameron, Laura Baranello, Maria G. Masucci

PLOS Pathogens: published September 20, 2021 | https://doi.org/10.1371/journal.ppat.1009954

Selective autophagic receptor NbNBR1 prevents NbRFP1-mediated UPS-dependent degradation of βC1 to promote geminivirus infection

Tingting Zhou, Mingzhen Zhang, Pan Gong, Fangfang Li, Xueping Zhou

PLOS Pathogens: published September 27, 2021 | https://doi.org/10.1371/journal.ppat.1009956

Cross-neutralization of SARS-CoV-2 by HIV-1 specific broadly neutralizing antibodies and polyclonal plasma

Nitesh Mishra, Sanjeev Kumar, Swarandeep Singh, Tanu Bansal, Nishkarsh Jain, Sumedha Saluja, Rajesh Kumar, Sankar Bhattacharyya, Jayanth Kumar Palanichamy, Riyaz Ahmad Mir, Subrata Sinha, Kalpana Luthra

PLOS Pathogens: published September 24, 2021 | https://doi.org/10.1371/journal.ppat.1009958

IRF3-mediated pathogenicity in a murine model of human hepatitis A

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PLOS Pathogens: published September 30, 2021 | https://doi.org/10.1371/journal.ppat.1009960

eIF4A, a target of siRNA derived from rice stripe virus, negatively regulates antiviral autophagy by interacting with ATG5 in Nicotiana benthamiana

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PLOS Pathogens: published September 29, 2021 | https://doi.org/10.1371/journal.ppat.1009963

Formal Comment

Research with variola virus after smallpox eradication: Development of a mouse model for variola virus infection

Bernard Moss, Geoffrey L. Smith

PLOS Pathogens: published September 21, 2021 | https://doi.org/10.1371/journal.ppat.1009911

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A sweet appetizer protects Aedes aegypti mosquitoes against arboviral infection

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**A sweet appetizer protects Aedes aegypti mosquitoes against arboviral infection**