Immunofluorescence staining of Hela cell infected with Salmonella Paratyphi A. Composition of three images showing intracellular Salmonella Paratyphi A (blue), flagella filaments (red) and LAMP1 (green).
Image Credit: Felix Scharte and Michael Hensel, Abt. Mikrobiologie, Universität Osnabrück. Both are coauthors of the paper and own the the copyright for this image.
Pearls
Is Candida albicans an opportunistic oncogenic pathogen?
PLOS Pathogens: published April 14, 2022 | https://doi.org/10.1371/journal.ppat.1010413
Exploitation of the Mediator complex by viruses
PLOS Pathogens: published April 21, 2022 | https://doi.org/10.1371/journal.ppat.1010422
Review
The FAR protein family of parasitic nematodes
PLOS Pathogens: published April 21, 2022 | https://doi.org/10.1371/journal.ppat.1010424
Research Articles
Long-read sequencing reveals complex patterns of wraparound transcription in polyomaviruses
PLOS Pathogens: published April 1, 2022 | https://doi.org/10.1371/journal.ppat.1010401
Early IL-17A production helps establish Mycobacterium intracellulare infection in mice
PLOS Pathogens: published April 1, 2022 | https://doi.org/10.1371/journal.ppat.1010454
High-resolution structures of malaria parasite actomyosin and actin filaments
PLOS Pathogens: published April 4, 2022 | https://doi.org/10.1371/journal.ppat.1010408
NK cells and monocytes modulate primary HTLV-1 infection
PLOS Pathogens: published April 4, 2022 | https://doi.org/10.1371/journal.ppat.1010416
PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence
PLOS Pathogens: published April 4, 2022 | https://doi.org/10.1371/journal.ppat.1010446
Coupled small molecules target RNA interference and JAK/STAT signaling to reduce Zika virus infection in Aedes aegypti
PLOS Pathogens: published April 4, 2022 | https://doi.org/10.1371/journal.ppat.1010411
Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to intracellular S. Typhimurium
PLOS Pathogens: published April 5, 2022 | https://doi.org/10.1371/journal.ppat.1010425
D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytes
PLOS Pathogens: published April 6, 2022 | https://doi.org/10.1371/journal.ppat.1010468
The WOPR family protein Ryp1 is a key regulator of gene expression, development, and virulence in the thermally dimorphic fungal pathogen Coccidioides posadasii
PLOS Pathogens: published April 6, 2022 | https://doi.org/10.1371/journal.ppat.1009832
Enterococcus faecalis alters endo-lysosomal trafficking to replicate and persist within mammalian cells
PLOS Pathogens: published April 7, 2022 | https://doi.org/10.1371/journal.ppat.1010434
Geminivirus C4 proteins inhibit GA signaling via prevention of NbGAI degradation, to promote viral infection and symptom development in N. benthamiana
PLOS Pathogens: published April 7, 2022 | https://doi.org/10.1371/journal.ppat.1010217
Spatial transcriptomics reveals antiparasitic targets associated with essential behaviors in the human parasite Brugia malayi
PLOS Pathogens: published April 7, 2022 | https://doi.org/10.1371/journal.ppat.1010399
The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model
PLOS Pathogens: published April 8, 2022 | https://doi.org/10.1371/journal.ppat.1010402
Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques
PLOS Pathogens: published April 8, 2022 | https://doi.org/10.1371/journal.ppat.1009990
Identification of a two-component regulatory system involved in antimicrobial peptide resistance in Streptococcus pneumoniae
PLOS Pathogens: published April 8, 2022 | https://doi.org/10.1371/journal.ppat.1010458
Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins
PLOS Pathogens: published April 8, 2022 | https://doi.org/10.1371/journal.ppat.1010353
Detailed analysis of antibody responses to SARS-CoV-2 vaccination and infection in macaques
PLOS Pathogens: published April 11, 2022 | https://doi.org/10.1371/journal.ppat.1010155
Candida albicans commensalism in the oral mucosa is favoured by limited virulence and metabolic adaptation
PLOS Pathogens: published April 11, 2022 | https://doi.org/10.1371/journal.ppat.1010012
A newly emerging alphasatellite affects banana bunchy top virus replication, transcription, siRNA production and transmission by aphids
PLOS Pathogens: published April 12, 2022 | https://doi.org/10.1371/journal.ppat.1010448
Host diversity and behavior determine patterns of interspecies transmission and geographic diffusion of avian influenza A subtypes among North American wild reservoir species
PLOS Pathogens: published April 13, 2022 | https://doi.org/10.1371/journal.ppat.1009973
The nuclear lamina binds the EBV genome during latency and regulates viral gene expression
PLOS Pathogens: published April 14, 2022 | https://doi.org/10.1371/journal.ppat.1010400
Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor
PLOS Pathogens: published April 14, 2022 | https://doi.org/10.1371/journal.ppat.1010464
Mycobacterium tuberculosis requires SufT for Fe-S cluster maturation, metabolism, and survival in vivo
PLOS Pathogens: published April 15, 2022 | https://doi.org/10.1371/journal.ppat.1010475
Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but moderately reduced lung inflammation
PLOS Pathogens: published April 20, 2022 | https://doi.org/10.1371/journal.ppat.1009925
Profiling metabolites and lipoproteins in COMETA, an Italian cohort of COVID-19 patients
PLOS Pathogens: published April 21, 2022 | https://doi.org/10.1371/journal.ppat.1010443
Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and influence the host response
PLOS Pathogens: published April 21, 2022 | https://doi.org/10.1371/journal.ppat.1009854
Blood vessel occlusion by Cryptococcus neoformans is a mechanism for haemorrhagic dissemination of infection
PLOS Pathogens: published April 21, 2022 | https://doi.org/10.1371/journal.ppat.1010389
Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection
PLOS Pathogens: published April 21, 2022 | https://doi.org/10.1371/journal.ppat.1010430
Identification of functionally important domains of human cytomegalovirus gO that act after trimer binding to receptors
PLOS Pathogens: published April 22, 2022 | https://doi.org/10.1371/journal.ppat.1010452
Astrovirus-induced epithelial-mesenchymal transition via activated TGF-β increases viral replication
PLOS Pathogens: published April 22, 2022 | https://doi.org/10.1371/journal.ppat.1009716
Reconstitution of EBV-directed T cell immunity by adoptive transfer of peptide-stimulated T cells in a patient after allogeneic stem cell transplantation for AITL
PLOS Pathogens: published April 22, 2022 | https://doi.org/10.1371/journal.ppat.1010206
HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys
PLOS Pathogens: published April 22, 2022 | https://doi.org/10.1371/journal.ppat.1010467
Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells
PLOS Pathogens: published April 26, 2022 | https://doi.org/10.1371/journal.ppat.1010453
GH18 family glycoside hydrolase Chitinase A of Salmonella enhances virulence by facilitating invasion and modulating host immune responses
PLOS Pathogens: published April 28, 2022 | https://doi.org/10.1371/journal.ppat.1010407
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Salmonella enterica serovar Typhimurium chitinases modulate the intestinal glycome and promote small intestinal invasion
PLOS Pathogens: published April 28, 2022 | https://doi.org/10.1371/journal.ppat.1010167
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Loquacious modulates flaviviral RNA replication in mosquito cells
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A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant
PLOS Pathogens: published April 28, 2022 | https://doi.org/10.1371/journal.ppat.1010465
The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment
PLOS Pathogens: published April 28, 2022 | https://doi.org/10.1371/journal.ppat.1010496
The SUMO E3 ligase activity of ORF45 determines KSHV lytic replication
PLOS Pathogens: published April 28, 2022 | https://doi.org/10.1371/journal.ppat.1010504
Therapeutic efficacy of humanized monoclonal antibodies targeting dengue virus nonstructural protein 1 in the mouse model
PLOS Pathogens: published April 29, 2022 | https://doi.org/10.1371/journal.ppat.1010469
Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection
PLOS Pathogens: published April 29, 2022 | https://doi.org/10.1371/journal.ppat.1010503
Correction
Correction: Interleukin-17 contributes to Ross River virus-induced arthritis and myositis
PLOS Pathogens: published April 27, 2022 | https://doi.org/10.1371/journal.ppat.1010519
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PLOS Pathogens: published April 11, 2022 | https://doi.org/10.1371/journal.ppat.1010480
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Formal Comment
On the genetic basis of the effect of Spiroplasma on the male reproductive fitness of Glossina fuscipes fuscipes
PLOS Pathogens: published April 4, 2022 | https://doi.org/10.1371/journal.ppat.1010442