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Table of Contents

June 2020

This image shows Plasmodium falciparum parasites, the causative agent of the most severe form of human malaria, inside a red blood cell. Newly divided daughter parasites are dark blue and the red blood cell is the transparent blue shroud surrounding the cells. This image is a 3D rendering of data produced by volume electron microscopy.

Image Credit: R Rudlaff (Boston Children's Hospital/Harvard Medical School), S Kraemer (Harvard Center for Nanoscale Systems), J Marshman (Zeiss Microscopy), and J Dvorin (Boston Children's Hospital/Harvard Medical School)

Opinions

In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction

Sandra Silva-Arrieta, Philip J. R. Goulder, Christian Brander

Biological sex impacts COVID-19 outcomes

Sabra L. Klein, Santosh Dhakal, Rebecca L. Ursin, Sharvari Deshpande, Kathryn Sandberg, Franck Mauvais-Jarvis

Pearls

Cellular plasticity of pathogenic fungi during infection

Kenya E. Fernandes, Dee A. Carter

Microbiome factors in HPV-driven carcinogenesis and cancers

Daniel Lin, Ramez Kouzy, Joseph Abi Jaoude, Sonal S. Noticewala, Andrea Y. Delgado Medrano, Ann H. Klopp, Cullen M. Taniguchi, Lauren E. Colbert

If looks could kill: Fungal macroscopic morphology and virulence

Caitlin H. Kowalski, Robert A. Cramer

Behavioral betrayal: How select fungal parasites enlist living insects to do their bidding

Brian Lovett, Angie Macias, Jason E. Stajich, John Cooley, Jørgen Eilenberg, Henrik H. de Fine Licht, Matt T. Kasson

How MHCII signaling promotes benign host-microbiota interactions

Mary Melissa Roland, Ahmed Dawood Mohammed, Jason Lee Kubinak

Research Articles

ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells

Shanhui Ren, Zaib Ur Rehman, Bo Gao, Zengqi Yang, Jiyong Zhou, Chunchun Meng, Cuiping Song, Venugopal Nair, Yingjie Sun, Chan Ding

Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts

Visnu Chaparro, Louis-Philippe Leroux, Laia Masvidal, Julie Lorent, Tyson E. Graber, Aude Zimmermann, Guillermo Arango Duque, Albert Descoteaux, Tommy Alain, Ola Larsson, Maritza Jaramillo

HIV-1 variants are archived throughout infection and persist in the reservoir

Kelsie Brooks, Bradley R. Jones, Dario A. Dilernia, Daniel J. Wilkins, Daniel T. Claiborne, Samantha McInally, Jill Gilmour, William Kilembe, Jeffrey B. Joy, Susan A. Allen, Zabrina L. Brumme, Eric Hunter

Tn-Seq reveals hidden complexity in the utilization of host-derived glutathione in Francisella tularensis

Kathryn M. Ramsey, Hannah E. Ledvina, Tenayaann M. Tresko, Jamie M. Wandzilak, Catherine A. Tower, Thomas Tallo, Caroline E. Schramm, S. Brook Peterson, Shawn J. Skerrett, Joseph D. Mougous, Simon L. Dove

A de novo approach to inferring within-host fitness effects during untreated HIV-1 infection

Christopher J. R. Illingworth, Jayna Raghwani, David Serwadda, Nelson K. Sewankambo, Merlin L. Robb, Michael A. Eller, Andrew R. Redd, Thomas C. Quinn, Katrina A. Lythgoe

Exploring potential of vaginal Lactobacillus isolates from South African women for enhancing treatment for bacterial vaginosis

Anna-Ursula Happel, Brian Kullin, Hoyam Gamieldien, Nicole Wentzel, Chambrez Z. Zauchenberger, Heather B. Jaspan, Smritee Dabee, Shaun L. Barnabas, Shameem Z. Jaumdally, Janan Dietrich, Glenda Gray, Linda-Gail Bekker, Remy Froissart, Jo-Ann S. Passmore

Potent, specific MEPicides for treatment of zoonotic staphylococci

Rachel L. Edwards, Isabel Heueck, Soon Goo Lee, Ishaan T. Shah, Justin J. Miller, Andrew J. Jezewski, Marwa O. Mikati, Xu Wang, Robert C. Brothers, Kenneth M. Heidel, Damon M. Osbourn, Carey-Ann D. Burnham, Sophie Alvarez, Stephanie A. Fritz, Cynthia S. Dowd, Joseph M. Jez, Audrey R. Odom John

Dynamic chromatin accessibility profiling reveals changes in host genome organization in response to baculovirus infection

Xiangshuo Kong, Guisheng Wei, Nan Chen, Shudi Zhao, Yunwang Shen, Jianjia Zhang, Yang Li, Xiaoqun Zeng, Xiaofeng Wu

Three-dimensional ultrastructure of Plasmodium falciparum throughout cytokinesis

Rachel M. Rudlaff, Stephan Kraemer, Jeffrey Marshman, Jeffrey D. Dvorin

Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virus

Pak-Hin Hinson Cheung, Tak-Wang Terence Lee, Chun Kew, Honglin Chen, Kwok-Yung Yuen, Chi-Ping Chan, Dong-Yan Jin

Human herpesvirus 6A promotes glycolysis in infected T cells by activation of mTOR signaling

Zhisheng Wu, Junli Jia, Xianyi Xu, Mengyuan Xu, Guangyong Peng, Jingjing Ma, Xuefeng Jiang, Jialin Yao, Kun Yao, Lingyun Li, Huamin Tang

HIV infects astrocytes in vivo and egresses from the brain to the periphery

Victoria Lutgen, Srinivas D. Narasipura, Hannah J. Barbian, Maureen Richards, Jennillee Wallace, Roshanak Razmpour, Tetyana Buzhdygan, Servio H. Ramirez, Lisa Prevedel, Eliseo A. Eugenin, Lena Al-Harthi

The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly

Gabrielle Vieyres, Isabelle Reichert, Arnaud Carpentier, Florian W. R. Vondran, Thomas Pietschmann

EBNA2-deleted Epstein-Barr virus (EBV) isolate, P3HR1, causes Hodgkin-like lymphomas and diffuse large B cell lymphomas with type II and Wp-restricted latency types in humanized mice

Chunrong Li, James C. Romero-Masters, Shane Huebner, Makoto Ohashi, Mitchell Hayes, Jillian A. Bristol, Scott E. Nelson, Mark R. Eichelberg, Nicholas Van Sciver, Erik A. Ranheim, Rona S. Scott, Eric C. Johannsen, Shannon C. Kenney

Peli1 signaling blockade attenuates congenital zika syndrome

Huanle Luo, Guangyu Li, Binbin Wang, Bing Tian, Junling Gao, Jing Zou, Shuizhen Shi, Shuang Zhu, Bi-Hung Peng, Awadalkareem Adam, Ariza Martinez, Kimberly Hein, Evandro R. Winkelmann, Yoseph Mahmoud, Xiaofei Zhou, Chao Shan, Shannan Rossi, Scott Weaver, Alan D. T. Barrett, Shao-Cong Sun, Wenbo Zhang, Pei-Yong Shi, Ping Wu, Tian Wang

Essential roles for deubiquitination in Leishmania life cycle progression

Andreas Damianou, Rebecca J. Burge, Carolina M. C. Catta-Preta, Vincent Geoghegan, Y. Romina Nievas, Katherine Newling, Elaine Brown, Richard Burchmore, Boris Rodenko, Jeremy C. Mottram

CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis

Jinhee Lee, Shayla Boyce, Jennifer Powers, Christina Baer, Christopher M. Sassetti, Samuel M. Behar

Patient genetics is linked to chronic wound microbiome composition and healing

Craig D. Tipton, Randall D. Wolcott, Nicholas E. Sanford, Clint Miller, Gita Pathak, Talisa K. Silzer, Jie Sun, Derek Fleming, Kendra P. Rumbaugh, Todd D. Little, Nicole Phillips, Caleb D. Phillips

Viral RNA is a target for Wolbachia-mediated pathogen blocking

Tamanash Bhattacharya, Irene L. G. Newton, Richard W. Hardy

MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer

Ethan L. Morgan, Molly R. Patterson, Emma L. Ryder, Siu Yi Lee, Christopher W. Wasson, Katherine L. Harper, Yigen Li, Stephen Griffin, G. Eric Blair, Adrian Whitehouse, Andrew Macdonald

Utilising animal models to evaluate oseltamivir efficacy against influenza A and B viruses with reduced in vitro susceptibility

Rubaiyea Farrukee, Celeste Ming-Kay Tai, Ding Yuan Oh, Danielle E. Anderson, Vithiagaran Gunalan, Martin Hibberd, Gary Yuk-Fai Lau, Ian G. Barr, Veronika von Messling, Sebastian Maurer-Stroh, Aeron C. Hurt

Engineered receptors for human cytomegalovirus that are orthogonal to normal human biology

Jihye Park, Kevin Sean Gill, Ali Asghar Aghajani, Jeremiah Dallas Heredia, Hannah Choi, Adam Oberstein, Erik Procko

Ubiquitin activation is essential for schizont maturation in Plasmodium falciparum blood-stage development

Judith L. Green, Yang Wu, Vesela Encheva, Edwin Lasonder, Adchara Prommaban, Simone Kunzelmann, Evangelos Christodoulou, Munira Grainger, Ngoc Truongvan, Sebastian Bothe, Vikram Sharma, Wei Song, Irene Pinzuti, Chairat Uthaipibull, Somdet Srichairatanakool, Veronique Birault, Gordon Langsley, Hermann Schindelin, Benjamin Stieglitz, Ambrosius P. Snijders, Anthony A. Holder

Bacterial killing by complement requires direct anchoring of membrane attack complex precursor C5b-7

Dennis J. Doorduijn, Bart W. Bardoel, Dani A. C. Heesterbeek, Maartje Ruyken, Georgina Benn, Edward S. Parsons, Bart W. Hoogenboom, Suzan H. M. Rooijakkers

A secreted LysM effector protects fungal hyphae through chitin-dependent homodimer polymerization

Andrea Sánchez-Vallet, Hui Tian, Luis Rodriguez-Moreno, Dirk-Jan Valkenburg, Raspudin Saleem-Batcha, Stephan Wawra, Anja Kombrink, Leonie Verhage, Ronnie de Jonge, H. Peter van Esse, Alga Zuccaro, Daniel Croll, Jeroen R. Mesters, Bart P. H. J. Thomma

Various miRNAs compensate the role of miR-122 on HCV replication

Chikako Ono, Takasuke Fukuhara, Songling Li, Jian Wang, Asuka Sato, Takuma Izumi, Yuzy Fauzyah, Takuya Yamamoto, Yuhei Morioka, Nikolay V. Dokholyan, Daron M. Standley, Yoshiharu Matsuura

Transmission modes affect the population structure of potato virus Y in potato

Washington da Silva, Denis Kutnjak, Yi Xu, Yimin Xu, James Giovannoni, Santiago F. Elena, Stewart Gray

Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB

Ruslana Bryk, Shashirekha Mundhra, Xiuju Jiang, Madeleine Wood, Daniel Pfau, Elaina Weber, Suna Park, Li Zhang, Colin Wilson, Renier Van der Westhuyzen, Leslie Street, Kelly Chibale, Matthew Zimmerman, Véronique Dartois, Nunzia Pastore, Andrea Ballabio, Natalie Hawryluk, Stacie Canan, Vikram Khetani, Joseph Camardo, Carl Nathan

Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation

Manzhi Zhao, Caoimhe H. Kiernan, Christopher J. Stairiker, Jennifer L. Hope, Leticia G. Leon, Marjan van Meurs, Inge Brouwers-Haspels, Ruben Boers, Joachim Boers, Joost Gribnau, Wilfred F. J. van IJcken, Eric M. Bindels, Remco M. Hoogenboezem, Stefan J. Erkeland, Yvonne M. Mueller, Peter D. Katsikis

Fluorescent protein tagging of adenoviral proteins pV and pIX reveals ‘late virion accumulation compartment’

Søren Pfitzner, Helga Hofmann-Sieber, Jens B. Bosse, Linda E. Franken, Kay Grünewald, Thomas Dobner

JNK pathway plays a key role in the immune system of the pea aphid and is regulated by microRNA-184

Li Ma, Lu Liu, Yujie Zhao, Lei Yang, Caihua Chen, Zhaofei Li, Zhiqiang Lu

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

Carlo Giannangelo, Ghizal Siddiqui, Amanda De Paoli, Bethany M. Anderson, Laura E. Edgington-Mitchell, Susan A. Charman, Darren J. Creek

Optimal priming of poxvirus vector (NYVAC)-based HIV vaccine regimens for T cell responses requires three DNA injections. Results of the randomized multicentre EV03/ANRS VAC20 Phase I/II Trial

Yves Lévy, Christine Lacabaratz, Kim Ellefsen-Lavoie, Wolfgang Stöhr, Jean-Daniel Lelièvre, Pierre-Alexandre Bart, Odile Launay, Jonathan Weber, Bernd Salzberger, Aurélie Wiedemann, Mathieu Surenaud, David M. Koelle, Hans Wolf, Ralf Wagner, Véronique Rieux, David C. Montefiori, Nicole L. Yates, Georgia D. Tomaras, Raphael Gottardo, Bryan Mayer, Song Ding, Rodolphe Thiébaut, Sheena McCormack, Geneviève Chêne, Giuseppe Pantaleo

Genome-wide transcriptomics identifies an early preclinical signature of prion infection

Silvia Sorce, Mario Nuvolone, Giancarlo Russo, Andra Chincisan, Daniel Heinzer, Merve Avar, Manuela Pfammatter, Petra Schwarz, Mirzet Delic, Micha Müller, Simone Hornemann, Despina Sanoudou, Claudia Scheckel, Adriano Aguzzi

An emerging role for cyclic dinucleotide phosphodiesterase and nanoRNase activities in Mycoplasma bovis: Securing survival in cell culture

Xifang Zhu, Eric Baranowski, Yaqi Dong, Xixi Li, Zhiyu Hao, Gang Zhao, Hui Zhang, Doukun Lu, Muhammad A. Rasheed, Yingyu Chen, Changmin Hu, Huanchun Chen, Eveline Sagné, Christine Citti, Aizhen Guo

Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E

Yuan Zhan, Shengqing Yu, Shen Yang, Xusheng Qiu, Chunchun Meng, Lei Tan, Cuiping Song, Ying Liao, Weiwei Liu, Yingjie Sun, Chan Ding

High-throughput sequencing analysis of a “hit and run” cell and animal model of KSHV tumorigenesis

Julian Naipauer, Daria Salyakina, Guy Journo, Santas Rosario, Sion Williams, Martin Abba, Meir Shamay, Enrique A. Mesri