Ultimate opportunists—The emergent Enterocytozoon group Microsporidia

Grant D. Stentiford, David Bass, Bryony A. P. Williams

PLOS Pathogens: published May 2, 2019 | https://doi.org/10.1371/journal.ppat.1007668

Go go gadget glycoprotein!: HSV-1 draws on its sizeable glycoprotein tool kit to customize its diverse entry routes

Adam T. Hilterbrand, Ekaterina E. Heldwein

PLOS Pathogens: published May 9, 2019 | https://doi.org/10.1371/journal.ppat.1007660

Unraveling the ecology and epidemiology of an emerging fungal disease, sea turtle egg fusariosis (STEF)

Christopher W. Smyth, Jullie M. Sarmiento-Ramírez, Dylan P. G. Short, Javier Diéguez-Uribeondo, Kerry O’Donnell, David M. Geiser

PLOS Pathogens: published May 16, 2019 | https://doi.org/10.1371/journal.ppat.1007682

The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid

Hayley E. Bullen, Hugo Bisio, Dominique Soldati-Favre

PLOS Pathogens: published May 23, 2019 | https://doi.org/10.1371/journal.ppat.1007670

A core set of venom proteins is released by entomopathogenic nematodes in the genus Steinernema

Dennis Z. Chang, Lorrayne Serra, Dihong Lu, Ali Mortazavi, Adler R. Dillman

PLOS Pathogens: published May 1, 2019 | https://doi.org/10.1371/journal.ppat.1007626

FOXO1 transcription factor plays a key role in T cell—HIV-1 interaction

Arthur Roux, Héloise Leroy, Bénédicte De Muylder, Lucie Bracq, Samia Oussous, Isabelle Dusanter-Fourt, Ghina Chougui, Rachida Tacine, Clotilde Randriamampita, Delphine Desjardins, Roger Le Grand, Frederic Bouillaud, Serge Benichou, Florence Margottin-Goguet, Remi Cheynier, Georges Bismuth, Marianne Mangeney

PLOS Pathogens: published May 1, 2019 | https://doi.org/10.1371/journal.ppat.1007669

Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and interaction with effectors of the innate immune system

Robert E. Smith, Bartłomiej Salamaga, Piotr Szkuta, Natalia Hajdamowicz, Tomasz K. Prajsnar, Gregory S. Bulmer, Thierry Fontaine, Justyna Kołodziejczyk, Jean-Marie Herry, Andrea M. Hounslow, Mike P. Williamson, Pascale Serror, Stéphane Mesnage

PLOS Pathogens: published May 2, 2019 | https://doi.org/10.1371/journal.ppat.1007730

Kaposi’s sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene expression

Sandra Koch, Modester Damas, Anika Freise, Elias Hage, Akshay Dhingra, Jessica Rückert, Antonio Gallo, Elisabeth Kremmer, Werner Tegge, Mark Brönstrup, Wolfram Brune, Thomas F. Schulz

PLOS Pathogens: published May 6, 2019 | https://doi.org/10.1371/journal.ppat.1007743

The t-SNARE protein FgPep12, associated with FgVam7, is essential for ascospore discharge and plant infection by trafficking Ca²⁺ ATPase FgNeo1 between Golgi and endosome/vacuole in Fusarium graminearum

Bing Li, Xin Dong, Rui Zhao, Rongchuan Kou, Xiaobo Zheng, Haifeng Zhang

PLOS Pathogens: published May 8, 2019 | https://doi.org/10.1371/journal.ppat.1007754

Multi-omics characterization of the necrotrophic mycoparasite Saccharomycopsis schoenii

Klara Junker, Anna Chailyan, Ana Hesselbart, Jochen Forster, Jürgen Wendland

PLOS Pathogens: published May 9, 2019 | https://doi.org/10.1371/journal.ppat.1007692

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle

Anna Płaszczyca, Pietro Scaturro, Christopher John Neufeldt, Mirko Cortese, Berati Cerikan, Salvatore Ferla, Andrea Brancale, Andreas Pichlmair, Ralf Bartenschlager

PLOS Pathogens: published May 9, 2019 | https://doi.org/10.1371/journal.ppat.1007736

A streptococcal Fic domain-containing protein disrupts blood-brain barrier integrity by activating moesin in endothelial cells

Zhe Ma, Jie Peng, Dandan Yu, Joseph S. Park, Huixing Lin, Bin Xu, Chengping Lu, Hongjie Fan, Matthew K. Waldor

PLOS Pathogens: published May 9, 2019 | https://doi.org/10.1371/journal.ppat.1007737

Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid

Liang Sun, Hyunwook Lee, Hendrik Jan Thibaut, Kristina Lanko, Eva Rivero-Buceta, Carol Bator, Belen Martinez-Gualda, Kai Dallmeier, Leen Delang, Pieter Leyssen, Federico Gago, Ana San-Félix, Susan Hafenstein, Carmen Mirabelli, Johan Neyts

PLOS Pathogens: published May 9, 2019 | https://doi.org/10.1371/journal.ppat.1007760

The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly

Oliver Looker, Adam J. Blanch, Boyin Liu, Juan Nunez-Iglesias, Paul J. McMillan, Leann Tilley, Matthew W. A. Dixon

PLOS Pathogens: published May 9, 2019 | https://doi.org/10.1371/journal.ppat.1007761

Impact of a patient-derived hepatitis C viral RNA genome with a mutated microRNA binding site

Miguel Mata, Steven Neben, Karim Majzoub, Jan Carette, Muthukumar Ramanathan, Paul A. Khavari, Peter Sarnow

PLOS Pathogens: published May 10, 2019 | https://doi.org/10.1371/journal.ppat.1007467

Structure and assembly of pilotin-dependent and -independent secretins of the type II secretion system

S. Peter Howard, Leandro F. Estrozi, Quentin Bertrand, Carlos Contreras-Martel, Timothy Strozen, Viviana Job, Alexandre Martins, Daphna Fenel, Guy Schoehn, Andréa Dessen

PLOS Pathogens: published May 13, 2019 | https://doi.org/10.1371/journal.ppat.1007731

Roles for E1-independent replication and E6-mediated p53 degradation during low-risk and high-risk human papillomavirus genome maintenance

Isao Murakami, Nagayasu Egawa, Heather Griffin, Wen Yin, Christian Kranjec, Tomomi Nakahara, Tohru Kiyono, John Doorbar

PLOS Pathogens: published May 13, 2019 | https://doi.org/10.1371/journal.ppat.1007755

On the evolutionary ecology of multidrug resistance in bacteria

Sonja Lehtinen, François Blanquart, Marc Lipsitch, Christophe Fraser, with the Maela Pneumococcal Collaboration

PLOS Pathogens: published May 13, 2019 | https://doi.org/10.1371/journal.ppat.1007763

Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques

Giulia Calenda, Ines Frank, Géraldine Arrode-Brusés, Amarendra Pegu, Keyun Wang, James Arthos, Claudia Cicala, Kenneth A. Rogers, Lisa Shirreff, Brooke Grasperge, James L. Blanchard, Stephanie Maldonado, Kevin Roberts, Agegnehu Gettie, Francois Villinger, Anthony S. Fauci, John R. Mascola, Elena Martinelli

PLOS Pathogens: published May 13, 2019 | https://doi.org/10.1371/journal.ppat.1007776

Early primed KLRG1^- CMV-specific T cells determine the size of the inflationary T cell pool

Nicolas S. Baumann, Suzanne P. M. Welten, Nicole Torti, Katharina Pallmer, Mariana Borsa, Isabel Barnstorf, Jennifer D. Oduro, Luka Cicin-Sain, Annette Oxenius

PLOS Pathogens: published May 13, 2019 | https://doi.org/10.1371/journal.ppat.1007785

Genome-wide screen identifies novel genes required for Borrelia burgdorferi survival in its Ixodes tick vector

James P. Phelan, Aurelie Kern, Meghan E. Ramsey, Maureen E. Lundt, Bijaya Sharma, Tao Lin, Lihui Gao, Steven J. Norris, Jenny A. Hyde, Jon T. Skare, Linden T. Hu

PLOS Pathogens: published May 14, 2019 | https://doi.org/10.1371/journal.ppat.1007644

Activity of CK2α protein kinase is required for efficient replication of some HPV types

Alla Piirsoo, Marko Piirsoo, Martin Kala, Eve Sankovski, Elina Lototskaja, Viktor Levin, Mauro Salvi, Mart Ustav

PLOS Pathogens: published May 15, 2019 | https://doi.org/10.1371/journal.ppat.1007788

The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression

Matthew E. Grunewald, Yating Chen, Chad Kuny, Takashi Maejima, Robert Lease, Dana Ferraris, Masanori Aikawa, Christopher S. Sullivan, Stanley Perlman, Anthony R. Fehr

PLOS Pathogens: published May 16, 2019 | https://doi.org/10.1371/journal.ppat.1007756

Limited HIV-2 reservoirs in central-memory CD4 T-cells associated to CXCR6 co-receptor expression in attenuated HIV-2 infection

Assia Samri, Charlotte Charpentier, Mariama Sadjo Diallo, Mélanie Bertine, Sophie Even, Véronique Morin, Anne Oudin, Christophe Parizot, Gilles Collin, Anne Hosmalin, Rémi Cheynier, Rodolphe Thiébaut, Sophie Matheron, Fideline Collin, Rima Zoorob, Françoise Brun-Vézinet, Brigitte Autran, the ANRS CO5 IMMUNOVIR-2 Study Group

PLOS Pathogens: published May 16, 2019 | https://doi.org/10.1371/journal.ppat.1007758

An integrative approach identifies direct targets of the late viral transcription complex and an expanded promoter recognition motif in Kaposi’s sarcoma-associated herpesvirus

Divya Nandakumar, Britt Glaunsinger

PLOS Pathogens: published May 16, 2019 | https://doi.org/10.1371/journal.ppat.1007774

EhP3, a homolog of 14-3-3 family of protein participates in actin reorganization and phagocytosis in Entamoeba histolytica

Shalini Agarwal, Gaurav Anand, Shalini Sharma, Pragyan Parimita Rath, Samudrala Gourinath, Alok Bhattacharya

PLOS Pathogens: published May 16, 2019 | https://doi.org/10.1371/journal.ppat.1007789

Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

Zhen-Yong Keck, Brian G. Pierce, Patrick Lau, Janine Lu, Yong Wang, Alexander Underwood, Rowena A. Bull, Jannick Prentoe, Rodrigo Velázquez-Moctezuma, Melanie R. Walker, Fabio Luciani, Johnathan D. Guest, Catherine Fauvelle, Thomas F. Baumert, Jens Bukh, Andrew R. Lloyd, Steven K. H. Foung

PLOS Pathogens: published May 17, 2019 | https://doi.org/10.1371/journal.ppat.1007772

Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response

Yu-Zhi Fu, Yi Guo, Hong-Mei Zou, Shan Su, Su-Yun Wang, Qing Yang, Min-Hua Luo, Yan-Yi Wang

PLOS Pathogens: published May 20, 2019 | https://doi.org/10.1371/journal.ppat.1007691

Triggering NETosis via protease-activated receptor (PAR)-2 signaling as a mechanism of hijacking neutrophils function for pathogen benefits

Danuta Bryzek, Izabela Ciaston, Ewelina Dobosz, Anna Gasiorek, Anna Makarska, Michal Sarna, Sigrun Eick, Magdalena Puklo, Maciej Lech, Barbara Potempa, Jan Potempa, Joanna Koziel

PLOS Pathogens: published May 20, 2019 | https://doi.org/10.1371/journal.ppat.1007773

Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection

Ignacio Santecchia, Frédérique Vernel-Pauillac, Orhan Rasid, Jessica Quintin, Maria Gomes-Solecki, Ivo G. Boneca, Catherine Werts

PLOS Pathogens: published May 20, 2019 | https://doi.org/10.1371/journal.ppat.1007811

Histamine release from intestinal mast cells induced by staphylococcal enterotoxin A (SEA) evokes vomiting reflex in common marmoset

Hisaya K. Ono, Shouhei Hirose, Kouji Narita, Makoto Sugiyama, Krisana Asano, Dong-Liang Hu, Akio Nakane

PLOS Pathogens: published May 21, 2019 | https://doi.org/10.1371/journal.ppat.1007803

Functional expression and characterization of the envelope glycoprotein E1E2 heterodimer of hepatitis C virus

Longxing Cao, Bowen Yu, Dandan Kong, Qian Cong, Tao Yu, Zibo Chen, Zhenzheng Hu, Haishuang Chang, Jin Zhong, David Baker, Yongning He

PLOS Pathogens: published May 22, 2019 | https://doi.org/10.1371/journal.ppat.1007759

The HPV-18 E7 CKII phospho acceptor site is required for maintaining the transformed phenotype of cervical tumour-derived cells

Om Basukala, Suruchi Mittal, Paola Massimi, Marco Bestagno, Lawrence Banks

PLOS Pathogens: published May 22, 2019 | https://doi.org/10.1371/journal.ppat.1007769

Circuit diversification in a biofilm regulatory network

Manning Y. Huang, Carol A. Woolford, Gemma May, C. Joel McManus, Aaron P. Mitchell

PLOS Pathogens: published May 22, 2019 | https://doi.org/10.1371/journal.ppat.1007787

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ZAP’s stress granule localization is correlated with its antiviral activity and induced by virus replication

Lok Man John Law, Brandon S. Razooky, Melody M. H. Li, Shihyun You, Andrea Jurado, Charles M. Rice, Margaret R. MacDonald

PLOS Pathogens: published May 22, 2019 | https://doi.org/10.1371/journal.ppat.1007798

Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS–MgrA signaling cascade

Jakub M. Kwiecinski, Heidi A. Crosby, Claire Valotteau, Joseph A. Hippensteel, Manasa K. Nayak, Anil K. Chauhan, Eric P. Schmidt, Yves F. Dufrêne, Alexander R. Horswill

PLOS Pathogens: published May 22, 2019 | https://doi.org/10.1371/journal.ppat.1007800

Strength of T cell signaling regulates HIV-1 replication and establishment of latency

Matthew Gagne, Daniel Michaels, Gillian M. Schiralli Lester, Suryaram Gummuluru, Wilson W. Wong, Andrew J. Henderson

PLOS Pathogens: published May 22, 2019 | https://doi.org/10.1371/journal.ppat.1007802

The R2TP complex regulates paramyxovirus RNA synthesis

Hiroshi Katoh, Tsuyoshi Sekizuka, Yuichiro Nakatsu, Reiko Nakagawa, Naganori Nao, Masafumi Sakata, Fumihiro Kato, Makoto Kuroda, Minoru Kidokoro, Makoto Takeda

PLOS Pathogens: published May 23, 2019 | https://doi.org/10.1371/journal.ppat.1007749

Clonorchis sinensis excretory-secretory products increase malignant characteristics of cholangiocarcinoma cells in three-dimensional co-culture with biliary ductal plates

Jihee Won, Youngkyu Cho, Dahyun Lee, Bo Young Jeon, Jung-Won Ju, Seok Chung, Jhang Ho Pak

PLOS Pathogens: published May 23, 2019 | https://doi.org/10.1371/journal.ppat.1007818

Blocking tombusvirus replication through the antiviral functions of DDX17-like RH30 DEAD-box helicase

Cheng-Yu Wu, Peter D. Nagy

PLOS Pathogens: published May 28, 2019 | https://doi.org/10.1371/journal.ppat.1007771

Cucumber mosaic virus infection as a potential selective pressure on Arabidopsis thaliana populations

Nuria Montes, Carlos Alonso-Blanco, Fernando García-Arenal

PLOS Pathogens: published May 28, 2019 | https://doi.org/10.1371/journal.ppat.1007810

Structure of a functional cap-binding domain in Rift Valley fever virus L protein

Nadja Gogrefe, Sophia Reindl, Stephan Günther, Maria Rosenthal

PLOS Pathogens: published May 28, 2019 | https://doi.org/10.1371/journal.ppat.1007829

SPI-1 is a missing host-range factor required for replication of the attenuated modified vaccinia Ankara (MVA) vaccine vector in human cells

Ruikang Liu, Jorge D. Mendez-Rios, Chen Peng, Wei Xiao, Andrea S. Weisberg, Linda S. Wyatt, Bernard Moss

PLOS Pathogens: published May 30, 2019 | https://doi.org/10.1371/journal.ppat.1007710

CD8⁺ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo

Bithi Chatterjee, Yun Deng, Angelika Holler, Nicolas Nunez, Tarik Azzi, Liliana Danusia Vanoaica, Anne Müller, Hana Zdimerova, Olga Antsiferova, Andrea Zbinden, Riccarda Capaul, Johannes H. Dreyer, David Nadal, Burkhard Becher, Mark D. Robinson, Hans Stauss, Christian Münz

PLOS Pathogens: published May 30, 2019 | https://doi.org/10.1371/journal.ppat.1007748

Chromulinavorax destructans, a pathogen of microzooplankton that provides a window into the enigmatic candidate phylum Dependentiae

Christoph M. Deeg, Matthias M. Zimmer, Emma E. George, Filip Husnik, Patrick J. Keeling, Curtis A. Suttle

PLOS Pathogens: published May 31, 2019 | https://doi.org/10.1371/journal.ppat.1007801

Correction: CD4⁺ T cells promote humoral immunity and viral control during Zika virus infection

Annie Elong Ngono, Matthew P. Young, Maximilian Bunz, Zhigang Xu, Sararat Hattakam, Edward Vizcarra, Jose Angel Regla-Nava, William W. Tang, Montarop Yamabhai, Jinsheng Wen, Sujan Shresta

PLOS Pathogens: published May 28, 2019 | https://doi.org/10.1371/journal.ppat.1007821

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