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Table of Contents

December 2019

Anti-PrP monoclonal antibody POM1, which binds to a discontinuous epitope of the C-terminal globular domain of mouse PrP, induces strong neurotoxicity in mice and cerebellar organotypic cultured slices. A cultured cerebellar organotypic cultured slice from tga20 transgenic mice remains healthy after being treated with Nb484, a Nanobody that inhibits prion propagation through binding to both the hydrophobic region and C-terminal domain of PrP, which highlights the great therapeutic potential of Nb484. Abskharon et al.

Image Credit: J Ruan, and R Abskharon (2019)

Pearls

Human immunity to Toxoplasma gondii

Daniel Fisch, Barbara Clough, Eva-Maria Frickel

Novel and emerging sources of Clostridioides difficile infection

Nicholas A. Turner, Becky A. Smith, Sarah S. Lewis

Protein–RNA interactions important for Plasmodium transmission

Kelly T. Rios, Scott E. Lindner

Research Articles

Fluorescent Crimean-Congo hemorrhagic fever virus illuminates tissue tropism patterns and identifies early mononuclear phagocytic cell targets in Ifnar-/- mice

Stephen R. Welch, Jana M. Ritter, Anita K. McElroy, Jessica R. Harmon, JoAnn D. Coleman-McCray, Florine E. M. Scholte, Gary P. Kobinger, Éric Bergeron, Sherif R. Zaki, Stuart T. Nichol, Jessica R. Spengler, Christina F. Spiropoulou

Dynamic organization of Herpesvirus glycoproteins on the viral envelope revealed by super-resolution microscopy

Frauke Beilstein, Gary H. Cohen, Roselyn J. Eisenberg, Valérie Nicolas, Audrey Esclatine, David Pasdeloup

Therapeutic monoclonal antibody treatment protects nonhuman primates from severe Venezuelan equine encephalitis virus disease after aerosol exposure

Crystal W. Burke, Jeffery W. Froude, Franco Rossi, Charles E. White, Crystal L. Moyer, Jane Ennis, M. Louise Pitt, Stephen Streatfield, R. Mark Jones, Konstantin Musiychuk, Jukka Kervinen, Larry Zeitlin, Vidadi Yusibov, Pamela J. Glass

Intra-host growth kinetics of dengue virus in the mosquito Aedes aegypti

Mario Novelo, Matthew D. Hall, Damie Pak, Paul R. Young, Edward C. Holmes, Elizabeth A. McGraw

Neisseria gonorrhoeae infects the heterogeneous epithelia of the human cervix using distinct mechanisms

Qian Yu, Liang-Chun Wang, Sofia Di Benigno, Scott D. Gray-Owen, Daniel C. Stein, Wenxia Song

A Pseudomonas aeruginosa type VI secretion system regulated by CueR facilitates copper acquisition

Yuying Han, Tietao Wang, Gukui Chen, Qinqin Pu, Qiong Liu, Yani Zhang, Linghui Xu, Min Wu, Haihua Liang

Silencing of transcription factor encoding gene StTCP23 by small RNAs derived from the virulence modulating region of potato spindle tuber viroid is associated with symptom development in potato

Sarina Bao, Robert A. Owens, Qinghua Sun, Hui Song, Yanan Liu, Andrew Leigh Eamens, Hao Feng, Hongzhi Tian, Ming-Bo Wang, Ruofang Zhang

ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type

Luca Schifanella, Susan W. Barnett, Massimiliano Bissa, Veronica Galli, Melvin N. Doster, Monica Vaccari, Georgia D. Tomaras, Xiaoying Shen, Sanjay Phogat, Ranajit Pal, David C. Montefiori, Celia C. LaBranche, Mangala Rao, Hung V. Trinh, Robyn Washington-Parks, Namal P. M. Liyanage, Dallas R. Brown, Frank Liang, Karin Loré, David J. Venzon, William Magnanelli, Michelle Metrinko, Josh Kramer, Matthew Breed, Galit Alter, Ruth M. Ruprecht, Genoveffa Franchini

Pathogenicity island excision during an infection by Salmonella enterica serovar Enteritidis is required for crossing the intestinal epithelial barrier in mice to cause systemic infection

Catalina Pardo-Roa, Geraldyne A. Salazar, Loreani P. Noguera, Francisco J. Salazar-Echegarai, Omar P. Vallejos, Isidora D. Suazo, Bárbara M. Schultz, Irenice Coronado-Arrázola, Alexis M. Kalergis, Susan M. Bueno

IgG Fc-binding motif-conjugated HIV-1 fusion inhibitor exhibits improved potency and in vivo half-life: Potential application in combination with broad neutralizing antibodies

Wenwen Bi, Wei Xu, Liang Cheng, Jing Xue, Qian Wang, Fei Yu, Shuai Xia, Qi Wang, Guangming Li, Chuan Qin, Lu Lu, Lishan Su, Shibo Jiang

Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice

John D. Ventura, Jagadish Beloor, Edward Allen, Tongyu Zhang, Kelsey A. Haugh, Pradeep D. Uchil, Christina Ochsenbauer, Collin Kieffer, Priti Kumar, Thomas J. Hope, Walther Mothes

Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa

Nuno R. Faria, Nicole Vidal, José Lourenco, Jayna Raghwani, Kim C. E. Sigaloff, Andy J. Tatem, David A. M. van de Vijver, Andrea-Clemencia Pineda-Peña, Rebecca Rose, Carole L. Wallis, Steve Ahuka-Mundeke, Jean-Jacques Muyembe-Tamfum, Jérémie Muwonga, Marc A. Suchard, Tobias F. Rinke de Wit, Raph L. Hamers, Nicaise Ndembi, Guy Baele, Martine Peeters, Oliver G. Pybus, Philippe Lemey, Simon Dellicour

Full-length human cytomegalovirus terminase pUL89 adopts a two-domain structure specific for DNA packaging

Janine Theiß, Min Woo Sung, Andreas Holzenburg, Elke Bogner

IL-22 produced by type 3 innate lymphoid cells (ILC3s) reduces the mortality of type 2 diabetes mellitus (T2DM) mice infected with Mycobacterium tuberculosis

Deepak Tripathi, Rajesh Kumar Radhakrishnan, Ramya Sivangala Thandi, Padmaja Paidipally, Kamakshi Prudhula Devalraju, Venkata Sanjeev Kumar Neela, Madeline Kay McAllister, Buka Samten, Vijaya Lakshmi Valluri, Ramakrishna Vankayalapati

A role of hypoxia-inducible factor 1 alpha in Murine Gammaherpesvirus 68 (MHV68) lytic replication and reactivation from latency

Darlah M. López-Rodríguez, Varvara Kirillov, Laurie T. Krug, Enrique A. Mesri, Samita Andreansky

Novel cholinesterase paralogs of Schistosoma mansoni have perceived roles in cholinergic signalling and drug detoxification and are essential for parasite survival

Bemnet A. Tedla, Javier Sotillo, Darren Pickering, Ramon M. Eichenberger, Stephanie Ryan, Luke Becker, Alex Loukas, Mark S. Pearson

A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen Candida albicans

Anaïs Burgain, Émilie Pic, Laura Markey, Faiza Tebbji, Carol A. Kumamoto, Adnane Sellam

Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation

Gianni Gori Savellini, Gabriele Anichini, Claudia Gandolfo, Shibily Prathyumnan, Maria Grazia Cusi

Dengue virus reduces AGPAT1 expression to alter phospholipids and enhance infection in Aedes aegypti

Thomas Vial, Wei-Lian Tan, Benjamin Wong Wei Xiang, Dorothée Missé, Eric Deharo, Guillaume Marti, Julien Pompon

Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion

Romany Abskharon, Fei Wang, Alexandre Wohlkonig, Juxin Ruan, Sameh Soror, Gabriele Giachin, Els Pardon, Wenquan Zou, Giuseppe Legname, Jiyan Ma, Jan Steyaert

Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model

Lorenz Loyola, Vasudevan Achuthan, Kathryn Gilroy, Gillian Borland, Anna Kilbey, Nancy Mackay, Margaret Bell, Jodie Hay, Sriram Aiyer, Dylan Fingerman, Rodrigo A. Villanueva, Ewan Cameron, Christine A. Kozak, Alan N. Engelman, James Neil, Monica J. Roth

Deep sequence analysis of HIV adaptation following vertical transmission reveals the impact of immune pressure on the evolution of HIV

Jennifer Currenti, Abha Chopra, Mina John, Shay Leary, Elizabeth McKinnon, Eric Alves, Mark Pilkinton, Rita Smith, Louise Barnett, Wyatt J. McDonnell, Michaela Lucas, Francine Noel, Simon Mallal, Joseph A. Conrad, Spyros A. Kalams, Silvana Gaudieri

Mouse APOBEC3 interferes with autocatalytic cleavage of murine leukemia virus Pr180gag-pol precursor and inhibits Pr65gag processing

Yoshiyuki Hakata, Jun Li, Takahiro Fujino, Yuki Tanaka, Rie Shimizu, Masaaki Miyazawa

Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence

Vincenzo Torraca, Myrsini Kaforou, Jayne Watson, Gina M. Duggan, Hazel Guerrero-Gutierrez, Sina Krokowski, Michael Hollinshead, Thomas B. Clarke, Rafal J. Mostowy, Gillian S. Tomlinson, Vanessa Sancho-Shimizu, Abigail Clements, Serge Mostowy

Identification of viral SIM-SUMO2-interaction inhibitors for treating primary effusion lymphoma

Ling Ding, Qing Zhu, Feng Zhou, Hongsheng Tan, Wenjia Xu, Chengling Pan, Caixia Zhu, Yuyan Wang, Hong Zhang, Wenwei Fu, Zhikang Qian, Zhenghong Yuan, Hongxi Xu, Fang Wei, Qiliang Cai

Re-assessing the diversity of negative strand RNA viruses in insects

Simon Käfer, Sofia Paraskevopoulou, Florian Zirkel, Nicolas Wieseke, Alexander Donath, Malte Petersen, Terry C. Jones, Shanlin Liu, Xin Zhou, Martin Middendorf, Sandra Junglen, Bernhard Misof, Christian Drosten

RNA interference identifies domesticated viral genes involved in assembly and trafficking of virus-derived particles in ichneumonid wasps

Ange Lorenzi, Marc Ravallec, Magali Eychenne, Véronique Jouan, Stéphanie Robin, Isabelle Darboux, Fabrice Legeai, Anne-Sophie Gosselin-Grenet, Mathieu Sicard, Don Stoltz, Anne-Nathalie Volkoff

Linking the effects of helminth infection, diet and the gut microbiota with human whole-blood signatures

Soo Ching Lee, Mei San Tang, Alice V. Easton, Joseph Cooper Devlin, Ling Ling Chua, Ilseung Cho, Foong Ming Moy, Tsung Fei Khang, Yvonne A. L. Lim, P’ng Loke

Alpha-defensin 5 differentially modulates adenovirus vaccine vectors from different serotypes in vivo

Lawrence J. Tartaglia, Alexander Badamchi-Zadeh, Peter Abbink, Eryn Blass, Malika Aid, Makda S. Gebre, Zhenfeng Li, Kevin Clyde Pastores, Sebastien Trott, Siddhant Gupte, Rafael A. Larocca, Dan H. Barouch

Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans

Nelson R. Wu, Nathan I. Nicely, Esther M. Lee, Rachel K. Reed, Brian E. Watts, Fangping Cai, William E. Walkowicz, Baptiste Aussedat, Julia A. Jones, Amanda Eaton, Ashley M. Trama, S. Munir Alam, David C. Montefiori, Barton F. Haynes, Kevin O. Saunders

Novel replisome-associated proteins at cellular replication forks in EBV-transformed B lymphocytes

Huanzhou Xu, Ramon D. Perez, Tiffany R. Frey, Eric M. Burton, Sudha Mannemuddhu, John D. Haley, Michael T. McIntosh, Sumita Bhaduri-McIntosh

IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody

Simone I. Richardson, Bronwen E. Lambson, Andrew R. Crowley, Arman Bashirova, Cathrine Scheepers, Nigel Garrett, Salim Abdool Karim, Nonhlanhla N. Mkhize, Mary Carrington, Margaret E. Ackerman, Penny L. Moore, Lynn Morris

Childhood immune imprinting to influenza A shapes birth year-specific risk during seasonal H1N1 and H3N2 epidemics

Katelyn M. Gostic, Rebecca Bridge, Shane Brady, Cécile Viboud, Michael Worobey, James O. Lloyd-Smith

The alternative cap-binding complex is required for antiviral defense in vivo

Anna Gebhardt, Valter Bergant, Daniel Schnepf, Markus Moser, Arno Meiler, Dieudonnée Togbe, Claire Mackowiak, Line S. Reinert, Søren R. Paludan, Bernhard Ryffel, Alexey Stukalov, Peter Staeheli, Andreas Pichlmair

Molecular anatomy of the receptor binding module of a bacteriophage long tail fiber

Mohammad Z. Islam, Andrei Fokine, Marthandan Mahalingam, Zhihong Zhang, Carmela Garcia-Doval, Mark J. van Raaij, Michael G. Rossmann, Venigalla B. Rao

A dispensable paralog of succinate dehydrogenase subunit C mediates standing resistance towards a subclass of SDHI fungicides in Zymoseptoria tritici

Diana Steinhauer, Marie Salat, Regula Frey, Andreas Mosbach, Torsten Luksch, Dirk Balmer, Rasmus Hansen, Stephanie Widdison, Grace Logan, Robert A. Dietrich, Gert H. J. Kema, Stephane Bieri, Helge Sierotzki, Stefano F. F. Torriani, Gabriel Scalliet

Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum

Zoltán Attila Nagy, Dávid Szakács, Eszter Boros, Dávid Héja, Eszter Vígh, Noémi Sándor, Mihály Józsi, Gábor Oroszlán, József Dobó, Péter Gál, Gábor Pál

Coxiella burnetii Type 4B Secretion System-dependent manipulation of endolysosomal maturation is required for bacterial growth

Dhritiman Samanta, Tatiana M. Clemente, Baleigh E. Schuler, Stacey D. Gilk

Innate and adaptive immunity associated with resolution of acute woodchuck hepatitis virus infection in adult woodchucks

Manasa Suresh, Stefanie Czerwinski, Marta G. Murreddu, Bhaskar V. Kallakury, Ashika Ramesh, Severin O. Gudima, Stephan Menne

Herpes simplex encephalitis in adult patients with MASP-2 deficiency

Stéphanie Bibert, Jocelyne Piret, Mathieu Quinodoz, Emilie Collinet, Vincent Zoete, Olivier Michielin, Rafik Menasria, Pascal Meylan, Titus Bihl, Véronique Erard, Florence Fellmann, Carlo Rivolta, Guy Boivin, Pierre-Yves Bochud

Iron availability and oxygen tension regulate the Yersinia Ysc type III secretion system to enable disseminated infection

Diana Hooker-Romero, Erin Mettert, Leah Schwiesow, David Balderas, Pablo A. Alvarez, Anadin Kicin, Azuah L. Gonzalez, Gregory V. Plano, Patricia J. Kiley, Victoria Auerbuch

Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance

Helen E. McNeil, Ilyas Alav, Ricardo Corona Torres, Amanda E. Rossiter, Eve Laycock, Simon Legood, Inderpreet Kaur, Matthew Davies, Matthew Wand, Mark A. Webber, Vassiliy N. Bavro, Jessica M. A. Blair

Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy

Eric B. Wong, Brian Montoya, Maria Ferez, Colby Stotesbury, Luis J. Sigal

PDGFRA defines the mesenchymal stem cell Kaposi’s sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment

Julian Naipauer, Santas Rosario, Sachin Gupta, Courtney Premer, Omayra Méndez-Solís, Mariana Schlesinger, Virginia Ponzinibbio, Vaibhav Jain, Lauren Gay, Rolf Renne, Ho Lam Chan, Lluis Morey, Daria Salyakina, Martin Abba, Sion Williams, Joshua M. Hare, Pascal J. Goldschmidt-Clermont, Enrique A. Mesri

Novel RNA viruses associated with Plasmodium vivax in human malaria and Leucocytozoon parasites in avian disease

Justine Charon, Matthew J. Grigg, John-Sebastian Eden, Kim A. Piera, Hafsa Rana, Timothy William, Karrie Rose, Miles P. Davenport, Nicholas M. Anstey, Edward C. Holmes

Cross-talk between microglia and neurons regulates HIV latency

David Alvarez-Carbonell, Fengchun Ye, Nirmala Ramanath, Yoelvis Garcia-Mesa, Pamela E. Knapp, Kurt F. Hauser, Jonathan Karn

IL-23 supports host defense against systemic Candida albicans infection by ensuring myeloid cell survival

Selim Nur, Florian Sparber, Christina Lemberg, Eva Guiducci, Tiziano A. Schweizer, Pascale Zwicky, Burkhard Becher, Salomé LeibundGut-Landmann

Correction

Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

Celia C. LaBranche, Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, Kevin O. Saunders, S. Munir Alam, Mattia Bonsignori, Mario J. Borgnia, Quentin J. Sattentau, Amanda Eaton, Kelli Greene, Hongmei Gao, Hua-Xin Liao, Wilton B. Williams, James Peacock, Haili Tang, Lautaro G. Perez, Robert J. Edwards, Thomas B. Kepler, Bette T. Korber, Peter D. Kwong, John R. Mascola, Priyamvada Acharya, Barton F. Haynes, David C. Montefiori

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