Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes
Plasmodium vivax contributes significantly to global malaria morbidity and remains a major obstacle for malaria elimination due to its ability to form dormant stages in the liver. Joyner et al.'s study reveals that P. cynomolgi- model relapse infections can be clinically silent in macaques due to rapid memory B cell responses that help to clear asexual-stage parasites but still carry gametocytes.
Image credit: Joyner CJ, et al. (2019)