11/27/2023
Research Article
Dual function of Zika virus NS2B-NS3 protease
ZIKV protease subunit is essential for viral replication and binds RNA in its inactive "open" conformation.
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November 10, 2023
Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2
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Read the latest Reviews in PLOS Pathogens
Peer-reviewed articles on topical areas of broad interest to the pathogens community.
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- Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells
- Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization
- Plasmodium falciparum utilizes pyrophosphate to fuel an essential proton pump in the ring stage and the transition to trophozoite stage
Current Issue November 2023
11/29/2023
Research Article
A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size
Variations in host gene expression, influenced by the transcriptionally active reservoir, might impact the HIV reservoir size.
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11/27/2023
Research Article
A chemosensory-like histidine kinase is dispensable for chemotaxis in vitro but regulates the virulence of Borrelia burgdorferi through modulating the stability of RpoS
CheA1's distinct role in regulating virulence factors provides fresh insights into B. burgdorferi's regulatory network.
Image credit: ppat.1011752
11/13/2023
Research Article
Amoeba predation of Cryptococcus: A quantitative and population genomic evaluation of the accidental pathogen hypothesis
New perspectives on how microbial ecology shapes the genetic architecture of fungal virulence.
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11/13/2023
Research Article
A sporulation signature protease is required for assembly of the spore surface layers, germination and host colonization in Clostridioides difficile
The general role of yabG in the assembly of the spore surface layers is likely to be conserved among spore-formers.
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11/15/2023
Research Article
The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity
ADAM10 supports HCV entry and cell-to-cell spread via EGFR family member transactivation.
Image credit: ppat.1011759
10/26/2023
Research Article
Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoes
A flavivirus genome recoding approach to overcome deoptimised flaviviruses based on optimising the flavivirus genome instead.
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10/26/2023
Research Article
Sugarcane streak mosaic virus P1 protein inhibits unfolded protein response through direct suppression of bZIP60U splicing
Plant viruses’ infection induce the UPR, and activated UPR often promotes plant viral infection.
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10/26/2023
Research Article
Virally encoded interleukin-6 facilitates KSHV replication in monocytes and induction of dysfunctional macrophages
Kaposi’s sarcoma-associated virus (KSHV) is the causative agent of highly inflammatory diseases that include Kaposi’s sarcoma and KSHV-inflammatory cytokine syndrome (KICS).
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PLOS Pathogens Microbiome Research: A Call for Papers
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Pathobiology and dysbiosis of the respiratory and intestinal microbiota in 14 months old Golden Syrian hamsters infected with SARS-CoV-2
Brittany Seibert, C. Joaquín Cáceres, and colleagues
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Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids
Qi-Yue Yang, Yong-Le Yang, and colleagues
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Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate
Frideborg Bradley and colleagues
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Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide
Jodie A. Schiffer & Stephanie V. Stumbur and colleagues
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Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
B. Karina Montero and colleagues
PLOS Pathogens Review articles
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Advances in understanding red blood cell modifications by Babesia
Hakimi et al.
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After the virus has cleared—Can preclinical models be employed for Long COVID research?
Jansen et al.
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Viral-mediated activation and inhibition of programmed cell death
Verburg et al.
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Molecular architecture of bacterial type IV secretion systems
Sheedlo et al.
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Bidirectional cytokine-microRNA control: A novel immunoregulatory framework in leishmaniasis
Jafarzadeh et al.
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