Blowing epithelial cell bubbles with GumB: ShlA-family pore-forming toxins induce blebbing and rapid cellular death in corneal epithelial cells
Brothers et al.'s study demonstrates that a subset of bacteria from the Enterobacteriaceae bacterial family induce cellular death and membrane blebs in a variety of cell types via a type V secretion-system dependent mechanism. This type V secretion-system mechanism likely enables access to deeper parts of the tissue that are more susceptible to infection.
Image credit: Brothers KM, et al. (2019)