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Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity

January 10, 2019

Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity

Pegan et al.

Image credit: Dzimianski JV,

PLOS Pathogens Invites Antifungal Immunity Research

Call for Papers

01/10/2019

Featured Research

Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection

Enterohemorrhagic Escherichia coli (EHEC), a food-borne pathogen that produces Shiga toxin. Balasubramanian et al. show that sufficient Shiga toxin was produced to cause lethal mouse disease, even without viral replication, potentially directing intervention strategies.

Image credit: Balasubramanian S, et al. (2019)

Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection

Recently Published Articles

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Current Issue

Current Issue December 2018

01/10/2019

Research Matters 

Unexpected lessons from the neglected: how defective viral genomes became important again

Carolina B. López studies the effect of defective viral genomes in modulating virus pathogenesis. In addition, her lab is interested in understanding the role of these types of genomes in shaping the long-term virus-host interaction. It is her hope that these studies, which were founded on curiosity, lead to a much more accurate understanding of the interaction between viruses and their host.

Image credit: López CB (2019)

Unexpected lessons from the neglected: how defective viral genomes became important again

01/10/2019

Pearls

Good to the last drop: The emergence of coffee ringspot virus

Two and a half billion times per day a human hand reaches for a fresh cup of coffee. Although arguably dispensable for life per se, with an industry value of US$174 billion, coffee provides the lifeblood that sustains economies of producing countries located in the “coffee belt” situated between the Tropics of Cancer and Capricorn. Goodin and Dos Reis Figueira's Pearl highlights important aspects of CoRSV, coffee ringspot virus, and its impacts on management systems.

Image credit: Goodin M, Dos Reis Figueira A (2019)

Good to the last drop: The emergence of coffee ringspot virus

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