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08/08/2019

Featured Research

Human apolipoprotein E promotes hepatitis B virus infection and production

Qiao and Luo's findings demonstrate that human apoE promotes HBV infection and production. The authors speculate that apoE may also play a role in persistent HBV infection by evading host immune response similar to its role in the HCV life cycle and pathogenesis. Inhibitors interfering with apoE biogenesis, secretion, and/or binding to receptors may serve as antivirals for elimination of chronic HBV infection.

Image credit: Qiao L, Luo GG (2019)

Human apolipoprotein E promotes hepatitis B virus infection and production

08/08/2019

Pearls

Helicobacter pylori and colorectal cancer—A bacterium going abroad?

Butt and Epplein discuss how there is growing evidence for H. pylori infection increasing CRC risk. A causal relationship and the mechanism behind this bacterium potentially acting abroad from its natural habitat, the stomach, however, still need to be clarified. Independent of a causal relationship, the knowledge of the association of H. pylori and CRC risk could help to define more rigid CRC screening programs for H. pylori–positive individuals.

Image credit: Butt J, Epplein M (2019)

Helicobacter pylori and colorectal cancer—A bacterium going abroad?

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