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Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes

June 6, 2022

Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes

A new research article from Nela Klimova and colleagues.

Image credit: Nela Klimova

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Peer-reviewed articles on topical areas of broad interest to the pathogens community.

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06/09/2022

Pearls

PARP14: A key ADP-ribosylating protein in host–virus interactions?

In this Pearls article, Parthasarathy & Fehr discuss PARP14, a MARylating enzyme that is implicated in a range of processes from tumorigenesis to DNA repair.

Image credit: Public Health Image Library from the Centers for Disease Control and Prevention

PARP14: A key ADP-ribosylating protein in host–virus interactions?

05/26/2022

Research Article

SARS-CoV-2-specific T cells associate with inflammation and reduced lung function in pulmonary post-acute sequalae of SARS-CoV-2

Littlefield et al. look for mechanisms behind long-term lung dysfunction following COVID-19 infection. They find that T cells specific for SARS-CoV-2 are elevated in the blood of those with pulmonary PASC and are associated with increased IL-6, a cytokine strongly associated with COVID-19 severity, and decreased lung function.

SARS-CoV-2-specific T cells associate with inflammation and reduced lung function in pulmonary post-acute sequalae of SARS-CoV-2

Image credit: Fusion Medical Animation, Unsplash

05/23/2022

Research Article

Live imaging of Yersinia translocon formation and immune recognition in host cells

Rudolph et al. present a novel method to film the spatiotemporal dynamics of the Yersinia T3SS translocon by inserting a small peptide tag into the minor translocon protein YopD that can be bound with high affinity by a corresponding fluorophore-labeled nanobody during the infection process.

Live imaging of Yersinia translocon formation and immune recognition in host cells

Image credit: Maren Rudolph and Martin Aepfelbacher

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PLOS Pathogens | ISSN: 1553-7374 (online)