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Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

January 14, 2019

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

Duque-Correa et al.

Image credit: Duque-Correa MA, et al. (2019)

PLOS Pathogens Invites Antifungal Immunity Research

New Speaking of Medicine Blog Post

Call for Papers

01/17/2019

Review

Roles, function and relevance of LAG3 in HIV infection

Graydon et al.'s review focuses on an immune checkpoint called LAG3. LAG3 can be present on many different immune cells with differing frequency but is more abundant during HIV, in which having more LAG3 is associated with certain aspects of worse disease. If combined with other drugs and strategies to fight HIV, checkpoint blockade may allow the immune system to control HIV without the help of antiviral drugs—a functional cure.

Image credit: Graydon CG, Balasko AL, Fowke KR (2019)

Roles, function and relevance of LAG3 in HIV infection

Recently Published Articles

Current Issue

Current Issue December 2018

01/17/2019

Research Article

Fibrillar structures induced by a plant reovirus target mitochondria to activate typical apoptotic response and promote viral infection in insect vectors

Chen et al.'s report that the replication of a plant reovirus, rice gall dwarf virus (RGDV), activated the apoptotic response in limited areas of leafhopper vectors during viral replication. This work presents a novel discovery that a plant reovirus induces typical apoptotic response and thus promotes its transmission by insect vectors.

Image credit: Chen Q, et al. (2019)

Fibrillar structures induced by a plant reovirus target mitochondria to activate typical apoptotic response and promote viral infection in insect vectors

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