August 10, 2020
Image credit: ppat.1008414
08/12/2020
Pearls
Convalescent plasma therapy, a century-old medical remedy, is being revisited as a viable and immediate option for mitigating the impact of SARS-CoV-2. In this Pearls article, Montelongo-Jauregui and colleagues discuss the potential benefits and drawbacks of this therapy in the mitigation of COVID-19.
Image credit: ppat.1008735
Current Issue July 2020
08/13/2020
Opinion
In this Opinion piece, Dannon Baker et al discuss the need for data sharing and research cooperation to tackle the SARS-CoV-2 global health emergency. They use public domain SARS-CoV-2 genomic data to (1) highlight the importance of access to raw data and (2) show that existing community efforts in curation of biomedical software can support rapid, reproducible research during global health crises.
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08/13/2020
Review
Mycobacterium tuberculosis (Mtb) infection in lymph nodes is understudied. Aside from being sites of initiation of the adaptive immune system, lymph nodes also serve as niches of Mtb growth and persistence. In this Review, Ganchua and colleagues discuss lymph nodes in relation to Mtb vaccine efficacy and highlight that future studies on anti-TB treatments should include consideration of the effects on thoracic lymph nodes and not just the lungs.
Image credit: ppat.1008632
08/10/2020
Research Article
Chowdhury, Modahl and colleagues characterize Aedes aegypti salivary gland (SG) immune response to dengue, Zika and chikungunya viruses using high-throughput transcriptomics. They reveal the broad antiviral function of JNK pathway in SGs and show that it is mediated by the complement system and apoptosis.
Image credit: ppat.1008754
08/12/2020
Research Article
Here, Harvey and Kumari et al see a Hyaloperonospora arabidopsidis effector mimicking a plant transcriptional repression motif and interacting with a transcriptional co-repressor in order to manipulate the plant immunity transcriptional response.
Image credit: ppat.1008835
08/11/2020
Research Article
Antanasijevic et al characterise computationally designed nanoparticle immunogens displaying trimeric HIV envelope glycoprotein (Env) ectodomains. Their findings indicate that tetrahedral nanoparticles can be successfully applied for presentation of HIV Env trimer immunogens.
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08/03/2020
Research Article
In this study by Katherine S. Forsyth and colleagues, they discuss how Ectromelia-encoded virulence factor C15 specifically inhibits antigen presentation to CD4+ T cells post peptide loading.
Image credit: ppat.1008685
08/13/2020
Research Article
Leptospiral LPS escapes mouse TLR4 internalization and TRIF‑associated antimicrobial responses through O antigen and associated lipoproteins. A new research article by Bonhomme and colleagues.
Image credit: ppat.1008639
08/11/2020
Research Article
Claire Scott and colleagues discuss the use of site-directed M2 proton channel inhibitors to enable synergistic combination therapy for rimantadine-resistant pandemic influenza.
Image credit: ppat.1008716
08/03/2020
Research Article
Ye, Su, Wrapp et al report the recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step.
Image credit: ppat.1008736
A Pearls article by Ludington and Ja
Margarida Sa Ribero, Nolwenn Jouvenet, Marlène Dreux & Sébastien Nisole
Sandra Silva-Arrieta, Philip J. R. Goulder & Christian Brander
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