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Crystal structure of a soluble fragment of poliovirus 2CATPase

September 19, 2018

Crystal structure of a soluble fragment of poliovirus 2CATPase

Image credit: Guan H, et al. (2018)

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PLOS Research News

09/20/2018

featured research

Manganese acquisition is essential for virulence of Enterococcus faecalis

The ability to acquire manganese during infection is essential for the virulence of E. faecalis in animals, according to this article by Lemos and colleagues. The authors identify major manganese acquisition systems of this opportunistic pathogen.Their findings suggest that these transporters are essential for the growth of E. faecalis in manganese-restricted environments. 

Image credit: Photo by Nathan Shankar, digital colorization by Stephen Ausmus. United States Department of Agriculture, 2009.

Manganese acquisition is essential for virulence of Enterococcus faecalis

09/20/2018

pearls

There was collusion: microbes in inflammatory bowel disease

Inflammatory bowel disease (IBD) refers to a group of chronic inflammatory diseases that affect the gastrointestinal tract and includes ulcerative colitis and Crohn’s disease (CD). Cadwell and Wong review the myriad microbes that have been interrogated in patients and laboratory models for their roles in IBD pathogenesis, highlighting the central importance of understanding host-microbe interactions. They discuss infectious triggers and gene-microbe interactions.

Image credit: Wong S-Y, Cadwell K (2018)

There was collusion: microbes in inflammatory bowel disease

09/20/2018

pearls

A Viral Trigger for Celiac Disease

Celiac disease (CD) is an autoimmune enteropathy that occurs in genetically susceptible individuals exposed to dietary gluten. CD occurs in approximately 1 in 133 persons in the United States. Dermody and colleagues assess the relationship between viruses and CD, including how some reovirus strains break oral tolerance. However they note that not all reovirus strains induce tolerance loss.

A Viral Trigger for Celiac Disease

Image credit: Brown JJ, Jabri B, Dermody TS (2018)

09/20/2018

research article

Prions activate a p38 MAPK synaptotoxic signaling pathway

Harris and colleagues' results provide powerful insights into the biology of prion neurotoxicity, they identify new, druggable therapeutic targets, and they allow comparison of prion synaptotoxic pathways with those involved in other neurodegenerative disorders like Alzheimer’s disease.

Prions activate a p38 MAPK synaptotoxic signaling pathway

Image credit: Fang C, et al. (2018)

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