January 19, 2021
Image credit: ppat.1009195
01/21/2021
Review
IRF1 is linked to to a wide range of functions in protection against invading pathogens. Hui Feng and colleagues review recent literature surrounding IRF1 and highlight how it mediates constitutive as well as inducible host defenses against a variety of viruses.
Image credit: ppat.1009220
Current Issue December 2020
01/21/2021
Pearls
In this Pearls article, Venkatesh and Singh examine the roles of G protein-coupled receptors (GPCRs) as noncanonical pattern recognition receptors (PRRs) and also discuss how GPCR signaling in C. elegans regulates various immune processes.
Image credit: ppat.1009151
01/21/2021
Review
Hannah Hanford and colleagues provide a comprehensive review discussing a diverse array of nucleomodulins that target and modulate the host genome through interference with chromatin dynamics, histone modifications, regulation of transcription, interference of the cell cycle, and regulation of cell signaling pathways for immune response.
Image credit: ppat.1009184
01/20/2021
Research Article
Swidergall and colleagues provide a deeper understanding of the interactions among C. albicans virulence factors, host cell receptors and immune responses during oropharyngeal candidiasis.
Image credit: ppat.1009221
01/19/2021
Research Article
López-Molina and colleagues describe the effects of Cry11Aa and Cyt1Aa toxins on gut structures, their localization and action after ingestion.
Image credit: ppat.1009199
01/19/2021
Research Article
Tianling Ou and colleagues identify functional differences between SARS-CoV-1 and -2 entry processes, and provide a mechanistic explanation for the limited in vivo utility of hydroxychloroquine as a treatment for COVID-19.
Image credit: ppat.1009212
01/21/2021
Research Article
Michihito Sasak et al find that SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells.
Image credit: ppat.1009233
01/21/2021
Research Article
Sowd and Aiken demonstrate that inositol phosphates promote HIV-1 assembly and maturation to facilitate viral spread in human CD4+ T cells.
Image credit: ppat.1009190
01/20/2021
Research Article
Olga Vladimirova and colleagues discuss how phase separation and DAXX redistribution contribute to LANA nuclear body and KSHV genome dynamics during latency and reactivation.
Image credit: ppat.1009231
01/19/2021
Research Article
Eric Carlin et al show extensive proteomic and transcriptomic changes that quench the TCR/CD3 activation signal of latently HIV-1 infected T cells.
Image credit: ppat.1008748
A Pearls article by Ludington and Ja
Connect with Us