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Molecular basis for functional diversity among microbial Nep1-like proteins

September 3, 2019

Molecular basis for functional diversity among microbial Nep1-like proteins

Lenarčič et al.

Image credit: Lenarčič T, et al. (2019)

09/05/2019

Pearls

Getting in: The structural biology of malaria invasion

Kumar and Tolia describe the structural and functional details of Plasmodium-specific invasion proteins involved in 1) traversal, 2) hepatocyte invasion, and 3) erythrocyte invasion. The current review focusses on the most virulent human malaria parasites, P. falciparum and P. vivax. Additional components of the invasion machinery are also excluded from the current study as they have been extensively reviewed elsewhere.

Image credit: Kumar H, Tolia NH (2019)

Getting in: The structural biology of malaria invasion

09/05/2019

Opinion

Promotion and induction of liver cancer by gut microbiome-mediated modulation of bile acids

Here, Jia and Jeon summarize recent studies describing the influence of the gut microbiome on liver cancer pathogenesis through BA-mediated regulation of the liver immune system. The findings summarized are expected to guide the development of strategies aimed at liver cancer prevention and clinical therapy by highlighting the gut microbiome as a therapeutic target.

Image credit: Jia B, Jeon CO (2019)

Promotion and induction of liver cancer by gut microbiome-mediated modulation of bile acids

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