December 20, 2019
Image credit: Welch SR, et al., 2019
12/12/2019
Pearls
In this PLOS Pathogens Pearls article, Daniel Fisch, Barbara Clough, and Eva-Maria Frickel share the latest in human immunity to T. gondii including innate immune response and Toxoplasma detection, the cellular response to infection, dissemination in the infected host, and entering of immune-privileged sites.
Image credit: Fisch D, et al. (2019)
Current Issue December 2019
12/19/2019
Research Article
Using a large epidemiological data set, Gostic and colleagues show birth year-specific differences in childhood immune imprinting, not differences in evolutionary rate, explain differences in H1N1 and H3N2’s age-specific impacts, emphasizing that childhood exposures can imprint a lifelong immunological bias toward particular influenza subtypes.
Image credit: Gostic KM, et al. (2019)
12/19/2019
Pearls
In this PLOS Pathogens Pearls article, Turner and colleagues discuss the changing epidemiology of C. difficile including risk factors associated with CA-CDI, potential novel sources of C. difficile, and how molecular epidemiology has improved our understanding of transmission.
Image credit: MIKI Yoshihito, Sapporo City General Hospital, flickr, 2013
12/16/2019
Research Article
Parasitic intestinal worms and gut bacteria occupy the same space, and the interaction is further complicated by dietary effects and the host immune response. In this research article Lee, Tang, and colleagues investigate the considerable interplay between intestinal worms and gut bacteria with zinc and iron levels in infected people.
Image credit: Lee SC, et al (2019)
12/09/2019
Research Article
Abskharon and colleagues provide the first structure-function evidence supporting a critical role of the hydrophobic region in forming the infectious prion and highlights the therapeutic potential of the nanobody, Nb484.
Image credit: Abskharon R, et al (2019)
12/13/2019
Research Article
Lorenzi and colleagues use RNAi combined with transmission electron microscopy, to show that the studied IVSPER genes are required in different steps of particle morphogenesis and trafficking, and that their functions are those expected of a typical virus.
Image credit: Lorenzi A, et al (2019)
12/19/2019
Research Article
Rao and colleagues use mutational, structural, and biochemical analyses to provide the first molecular description of a tail fiber tip, including patches of binding sites that allow dynamic interactions with LPS or OmpC
Image credit: Islam MZ, et al. (2019)
12/19/2019
Research Article
Pichlmair and colleagues provide evidence that NCBP3 is essential to mount a precise and appropriate antiviral response during infection.
Image credit: Gebhardt A, et al. (2019)
12/02/2019
Research Article
Bao and colleagues show transcription factor encoding gene, StTCP23, positively regulates potato sprouting, tuber development via GA-related mechanism.
Image credit: Bao S, et al. (2019)
12/02/2019
Research Article
Johnston and colleagues show KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication.
Image credit: quapan, flicker, 2019
Harris and colleagues.
A PLOS Pathogens Opinion article by Dheilly and colleagues.
Cheng, Chen, Huang, and colleagues
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