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February 21, 2025

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06/05/2025

research article

Induction of tunnelling nanotube-like structures by influenza A viruses requires the onset of apoptosis

Here, the authors show that tunnelling nanotube-like structures are formed by influenza A virus-infected cells in vivo, and use in vitro models to ask how IAVs induce their formation. They find that TLS formation requires intracellular viral replication and correlates with apoptosis, which in turn promotes direct cell-to-cell viral spread.

Image credit: ppat.1013191

Induction of tunnelling nanotube-like structures by influenza A viruses requires the onset of apoptosis

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PLOS Pathogens | ISSN: 1553-7374 (online)