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Born to sweet delight: Using natural models of malaria protection to understand and neutralize P. falciparum pathogenesis

June 20, 2019

Born to sweet delight: Using natural models of malaria protection to understand and neutralize P. falciparum pathogenesis

A new Pearl from Saelens and Taylor 

Image credit: NASA/Kathryn Hansen, 2011

Microbes and Host  Cell Membrane Interactions

New Call for Papers from PLOS Pathogens and PLOS ONE!

Submit by Oct 18

06/20/2019

Featured research

Blowing epithelial cell bubbles with GumB: ShlA-family pore-forming toxins induce blebbing and rapid cellular death in corneal epithelial cells

Brothers et al.'s study demonstrates that a subset of bacteria from the Enterobacteriaceae bacterial family induce cellular death and membrane blebs in a variety of cell types via a type V secretion-system dependent mechanism.  This type V secretion-system mechanism likely enables access to deeper parts of the tissue that are more susceptible to infection.

Image credit: Brothers KM, et al. (2019)

Blowing epithelial cell bubbles with GumB: ShlA-family pore-forming toxins induce blebbing and rapid cellular death in corneal epithelial cells

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