Graydon et al.'s review focuses on an immune checkpoint called LAG3. LAG3 can be present on many different immune cells with differing frequency but is more abundant during HIV, in which having more LAG3 is associated with certain aspects of worse disease. If combined with other drugs and strategies to fight HIV, checkpoint blockade may allow the immune system to control HIV without the help of antiviral drugs—a functional cure.
Image credit: Graydon CG, Balasko AL, Fowke KR (2019)