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Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance

March 6, 2020

Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance

A new research article from Kelsey J. Yamada and colleagues

Image credit: Flickr NIAID

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Current Issue March 2020

03/12/2020

Research Article

Structural basis of Fusarium myosin I inhibition by phenamacril

Fusarium graminearum is a species of filamentous fungi that causes devastating disease in major staple crops. Phenamacril is a recently identified myosin I inhibitor that is a potent and highly species-specific and myosin subtype-selective fungicide. Zhou et al report the high-resolution structure of the phenamacril-bound myosin I motor domain of this major crop pathogen, providing insight into the molecular mechanism of phenamacril action and resistance.

Image credit: ppat.1008323

Structural basis of Fusarium myosin I inhibition by phenamacril

03/09/2020

Research Article

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion

The intracellular bacterium Burkholderia thailandensis invades the cytosol, hijacks host actin, and induces cell fusion to spread to adjacent cells, forming multinucleated giant cells which promote bacterial replication. Place and colleagues reveal that IFN and GBPs play a critical role in restricting cell-cell fusion and bacteria-induced pathology during infection.

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion

Image credit: ppat.1008364

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