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03/21/2019

Featured Research

Inflammatory monocytes are detrimental to the host immune response during acute infection with Cryptococcus neoformans

C. neoformans is a leading cause of invasive fungal infections among immunocompromised patients. Heung and Holh used a mouse model of lethal C. neoformans infection to determine that inflammatory monocytes, immune cells that are often among the first responders to infections, actually facilitate the progression of infection rather than clearance. 

Image credit: Heung LJ, Hohl TM (2019)

Inflammatory monocytes are detrimental to the host immune response during acute infection with Cryptococcus neoformans

Recently Published Articles

Current Issue

Current Issue February 2019

03/21/2019

Pearls

Viva lavidaviruses! Five features of virophages that parasitize giant DNA viruses

In this Pearl, Duponchel and Fischer discuss virophages. Virophages are fascinating eukaryotic DNA viruses that have evolved to depend on a co-infecting GV instead of replicating in the host cell nucleus. They possess a high degree of genome mobility that may compensate for their unusual host requirements. The long co-evolution of virophages with their viral and cellular hosts has led to unique adaptations, such as the mutualistic Cafeteria–mavirus relationship. 

Image credit: Duponchel S, Fischer MG (2019)

Viva lavidaviruses! Five features of virophages that parasitize giant DNA viruses

03/21/2019

Review

Macrophage nuclear receptors: Emerging key players in infectious diseases

Nuclear receptors (NRs) are ligand-activated transcription factors that are expressed in a variety of cells, including macrophages. Schlesinger et al. discuss recent findings concerning the role of NRs in infectious diseases with an emphasis on PPARγ and LXR, the two most studied. The authors also highlight newer work on the activity of emerging NRs during infection.

Image credit: Leopold Wager CM, Arnett E, Schlesinger LS (2019)

Macrophage nuclear receptors: Emerging key players in infectious diseases

03/21/2019

Research Article

Low levels of SIV-specific CD8+ T cells in germinal centers characterizes acute SIV infection

CD8+ T cells play an important role in controlling of HIV and SIV infections. However, these cells are largely excluded from B cell follicles .Li et al.'s studies suggest that a paucity of SIV-specific CD8+ T cells in follicles and complete absence within GCs during early infection may set the stage for the establishment of persistent chronic infection. 

Low levels of SIV-specific CD8+ T cells in germinal centers characterizes acute SIV infection

Image credit: Li S, et al. (2019)

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