10/15/2020
Review
Autumn C. Holmes and colleagues review recent developments in the molecular understanding of alphavirus entry both in vitro and in vivo and how these advances might enable the design of therapeutics targeting this critical step in the alphavirus life cycle.
Image credit: ppat.1008876
Current Issue September 2020
10/22/2020
Review
Han Du and colleagues review progress made over the past decade on the biological and clinical aspects of C. auris. The define priorities for future work as understanding the mechanistic details of its biology, epidemiology, antifungal resistance, and pathogenesis with a goal of developing novel tools and methods for the prevention, diagnosis, and treatment of C. auris infections.
Image credit: ppat.1008921
10/22/2020
Pearls
In this Pearls article, Eleonora Chinchio and colleagues discuss invasive alien species from a health perspective and how they can present challenges, both as sources of new pathogens and as amplifiers of local pathogens and infection dynamics. This work stresses the need to promote responsible behaviors when crossing borders and to improve the general public attitude toward IAS control and eradication programs.
Image credit: ppat.1008922
10/08/2020
Research Article
Qiao et al provide novel evidence that HSV-1 infection impaired human brain development and contributed to neurodevelopmental disorder pathogen hypothesis, and would have implications for raising the therapeutic opportunities for targeting of viral reservoirs relevant to neurodevelopmental disorder.
Image credit: ppat.1008899
10/02/2020
Research Article
Crisford & Calahorro et al identify key components of the serotonin signalling pathway in Globodera pallida and show that chemicals that target these sites also inhibit ability to invade the host plant, providing insight into new targets for crop protection.
Image credit: Florida Division of Plant Industry
10/08/2020
Research Article
Puhach et al study the viral m139 gene, which is important for virus replication in macrophages and endothelial cells and for dissemination in the mouse, and identify m139 as a new viral DDX3 inhibitor, which curtails the production of interferon by macrophages.
Image credit: ppat.1008546
10/05/2020
Research Article
Hakimi and colleagues provide new insights into the host cell modifications by Babesia bovis and their pathogenicity.
Image credit: ppat.1008917
10/07/2020
Research Article
Ohno et al provide insights into how gut microbes control colitis via the complement system.
Image credit: ppat.1008928
10/01/2020
Research Article
Mei at al uncover a novel strategy deployed by geminiviruses to counter anti-viral DNA methylation.
Image credit: ppat.1008829
10/02/2020
Research Article
Li-hui He and colleagues demonstrate the crucial role of CfaA-CfaE in CFA/I fimbriae production, providing guidance for further development of novel agents targeting CFA/I fimbriae and against enterotoxigenic E.coli infection.
Image credit: ppat.1008848
A Pearls article by Ludington and Ja
Margarida Sa Ribero, Nolwenn Jouvenet, Marlène Dreux & Sébastien Nisole
Sandra Silva-Arrieta, Philip J. R. Goulder & Christian Brander
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