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Mucosal immunoglobulins protect the olfactory organ of teleost fish against parasitic infection

November 5, 2018

Mucosal immunoglobulins protect the olfactory organ of teleost fish against parasitic infection

Yu et al.

Image credit: Yu Y-Y, et al. (2018)

11/08/2018

pearl

The calendar of epidemics: Seasonal cycles of infectious diseases

Seasonal variation in infectious disease transmission plays an important role in determining when epidemics happen; however, it is not the sole determinant. In this Pearl, Micaela Martinez aims to provide a holistic overview of existing studies on seasonality and motivate future studies of disease seasonality by drawing attention to the importance of seasonality in public health, medicine, and biology. 

Image credit: Martinez ME (2018)

The calendar of epidemics: Seasonal cycles of infectious diseases

Recently Published Articles

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Current Issue October 2018

11/05/2018

Research Article

HEXIM1-Tat chimera inhibits HIV-1 replication

Transcription of HIV provirus is a key step of the viral cycle, and depends on the recruitment of the cellular positive transcription elongation factor (P-TEFb) to the HIV promoter. Leoz et al 's proof-of-concept study validates an innovative approach to interfering with HIV transcription via peptide mimicry and competition for RNA-protein interactions. HT1 represents a new candidate for HIV therapy, or HIV cure via the proposed block and lock strategy.

Image credit: Leoz M, et al. (2018)

HEXIM1-Tat chimera inhibits HIV-1 replication

11/05/2018

Research Article

HIV-1 Envelope Glycan Modifications that Permit Neutralization by Germline-Reverted VRC01-Class Broadly Neutralizing Antibodies

Broadly neutralizing antibody (bnAb) induction is a high priority for effective HIV-1 vaccination. LaBranche et al.'s indings improve our understanding of the restrictions imposed by glycans in eliciting VRC01-class bnAbs and enable a neutralization-based strategy to monitor vaccine-elicited early precursors of this class of bnAbs.

Image credit: LaBranche CC, et al. (2018)

HIV-1 Envelope Glycan Modifications that Permit Neutralization by Germline-Reverted VRC01-Class Broadly Neutralizing Antibodies

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