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Tuberculosis drug discovery in the CRISPR era

September 19, 2019

Tuberculosis drug discovery in the CRISPR era

A New Pearl from Jeremy Rock 

Image credit: Caroline Davis, 2010

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09/19/2019

Featured Research

Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes

Plasmodium vivax contributes significantly to global malaria morbidity and remains a major obstacle for malaria elimination due to its ability to form dormant stages in the liver. Joyner et al.'s study reveals that P. cynomolgi- model relapse infections can be clinically silent in macaques due to rapid memory B cell responses that help to clear asexual-stage parasites but still carry gametocytes.

Image credit: Joyner CJ, et al. (2019)

Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes

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Current Issue October 2019

09/19/2019

Featured Research

A robust human norovirus replication model in zebrafish larvae

Van Dycke et al. report that HuNoV GI and GII replicate to high titers in zebrafish (Danio rerio) larvae; replication peaks at day 2 post infection and is detectable for at least 6 days. Zebrafish larvae constitute a simple and robust replication model that will largely facilitate studies of HuNoV biology and the development of antiviral strategies.

Image credit: Van Dycke J, et al. (2019)

A robust human norovirus replication model in zebrafish larvae

09/19/2019

Research Article

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

DENV2 particles have been shown to change their morphologies (compact smooth to loose bumpy surfaced) when temperature is switched from 28°C to 37°C. Lim et al. investigate whether the bumpy morphology also occurs in DENV2 clinical isolates, and showed that these viruses can exhibit both morphologies, indicating that vaccine and therapeutics development should target both virus forms.

Image credit: Lim X-N, et al. (2019)

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

09/12/2019

Research Article

The molecular clock of Mycobacterium tuberculosis

The molecular clock and its phylogenetic applications to genomic data have changed how we study and understand one of the major human pathogens, Mycobacterium tuberculosis. Menardo et al. characterized the rate of molecular evolution (the pace of the clock), and its variation between different MTB populations and lineages. Their results provide an important guideline for future analyses of tuberculosis and other organisms.

The molecular clock of Mycobacterium tuberculosis

Image credit: Menardo F, et al. (2019)

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