February 21, 2025

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05/16/2025

pearls

Fast and flu-rious: How to prevent and treat emerging influenza A viruses

This article explores influenza A virus, a highly adaptable zoonotic pathogen behind seasonal flu and pandemics. It examines the biological mechanisms that enable IAV to cross species barriers and evolve rapidly, particularly through mutation and reassortment, making it difficult to control. The authors assess current prevention and treatment strategies, highlight emerging threats and outline recent technological and scientific advances to improve pandemic preparedness.

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Fast and flu-rious: How to prevent and treat emerging influenza A viruses

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Current Issue May 2025

05/12/2025

review

TRIM proteins: A ‘swiss army knife’ of antiviral immunity

With their modular structure and E3 ubiquitin ligase activity, Tripartite motif proteins interact with a range of cellular and viral substrates. This review highlights their role in the antiviral response and details the two complementary modes of regulation by TRIM proteins: their indirect antiviral actions, mediated through various cellular pathways, and their direct effects on the viral life cycle. It also examines viral strategies emerging from the co-evolution between viruses and TRIMs.

Image credit: ppat.1013147

TRIM proteins: A ‘swiss army knife’ of antiviral immunity

05/07/2025

pearls

Candida auris is emerging as a prevalent urinary pathogen

C. auris has rapidly emerged as a clinically significant pathogen due to its antifungal resistance, high mortality rates, and limited understanding around its prevalence and pathophysiology. To understand whether C. auris is prevalent in the urinary tract, here the authors analyzed 12,996 C. auris clinical strains, identifying urine as the second most common C. auris isolation source in the United States and the third most common worldwide.

Image credit: ppat.1013138

Candida auris is emerging as a prevalent urinary pathogen

05/06/2025

research article

Stomoxys flies (Diptera, Muscidae) are competent vectors of Trypanosoma evansi, Trypanosoma vivax, and other livestock hemopathogens

In this article, the authors studied the feeding patterns of Stomoxys flies collected from specific locations in Kenya to identify various vertebrate hosts they fed on, the livestock hemopathogens they carried, and to elucidate their role in pathogens transmission.

Image credit: ppat.1012570

05/12/2025

research article

Reversible host cell surface remodelling limits immune recognition and maximizes survival of Plasmodium falciparum gametocytes

In this article, the authors show that surface antigen expression, serum reactivity by human IgG, and opsonic phagocytosis by macrophages follow similar dynamics during gametocyte maturation: peaking in the immature stages and tapering off in mature gametocytes.

Image credit: ppat.1013110

05/09/2025

research article

Evolution of primate T-cell leukemia virus type 1 accessory genes and functional divergence of its antisense proteins

This study characterizes the genetic diversity of different Primate T-cell leukemia virus type 1 (PTLV-1) subtypes and examines their association with geographical locations and host species.

Image credit: ppat.1013158

05/07/2025

Research article

In vivo Dicer-2 interactome during viral infection reveals novel pro and antiviral factors in Drosophila melanogaster

This work highlights protein complexes assembled around Dicer-2 in vivo, and provides a resource to investigate their contribution to antiviral RNAi and related pathways.

Image credit: ppat.1013093

05/23/2025

research article

Stylet cuticular gene-directed mutagenesis impairs the pea aphid vector capacity to transmit a plant virus

In this study, the authors characterized the phenotype of two pea aphid Stylin-01 mutant lines, the first generated with CRISPR/Cas9 in this hemipteran.

Image credit: ppat.1013192

05/19/2025

research article

Hydrogen sulfide (H2S) coordinates redox balance, carbon metabolism, and mitochondrial bioenergetics to suppress SARS-CoV-2 infection

Here, the authors report that the gas hydrogen sulfide regulates redox, metabolism, and mitochondrial bioenergetics to control SARS-CoV-2.

Image credit: ppat.1013164

05/13/2025

research article

Caspase-1-licensed pyroptosis drives dsRNA-mediated necroptosis and dampens host defense against bacterial pneumonia

Here, the authors show that two types of regulated cell death, pyroptosis and necroptosis, contribute to the pathobiology of bacterial lung infections.

Image credit: ppat.1013167

PLOS Pathogens Microbiome Research: A Call for Papers

Pathobiology and dysbiosis of the respiratory and intestinal microbiota in 14 months old Golden Syrian hamsters infected with SARS-CoV-2

Brittany Seibert, C. Joaquín Cáceres, and colleagues
Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids

Qi-Yue Yang, Yong-Le Yang, and colleagues
Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate

Frideborg Bradley and colleagues
Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide

Jodie A. Schiffer & Stephanie V. Stumbur and colleagues
Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate

B. Karina Montero and colleagues

What is happening at PLOS Pathogens?

Exciting News: New Editor-in-Chief Joins in 2025

We are pleased to announce that Sumita Bhaduri-McIntosh joined us as second Editor-in-Chief at the beginning of 2025. With this addition, we are thrilled to once again have a dynamic dual leadership team guiding the journal.
Discover Our Updated Editorial Board Webpage!

We're excited about our revised and synchronized Editorial Board webpage—now enhanced with a brand-new search functionality!

Easily find and explore board members with our improved layout and seamless navigation.
PLOS Pathogens welcomes the latest additions to our senior leadership team

We've been thrilled to welcome:

Helena Boshoff, Thomas Guillard, Thomas Hoenen, Francis Jiggins, Robert Kalejta, Tracey Lamb, Edward Mitre, and Alice Prince!
PLOS statement on recent US Executive Orders and scientific integrity

PLOS will always anchor our decisions in our values and our principles. And we will continue to speak up vocally for open, independent science.

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