July 8, 2020
Image credit: ppat.1008623
06/22/2020
Opinion
The current COVID-19 pandemic is revealing profound differences between men and women in disease outcomes worldwide. This Opinion article by Klein and colleagues aims to raise awareness about the male-biased severe outcomes from COVID-19, highlighting mechanistic differences and how sex differences in comorbidities impact male-biased outcomes from COVID-19.
Image credit: NIAID
Current Issue June 2020
07/02/2020
Pearls
There is an increasing urgency in gaining greater understanding of the factors that affect vulnerability to extinction, given the current levels of species loss. Carmona-Isunza and Ancona et al stress the importance of assessing the occurrence of haemosporidians and other parasites in vertebrate species of high conservation concern in this Pearls article.
Image credit: Flickr user Ron Knight
06/29/2020
Pearls
In this Pearls article, Roland, Mohammed and Kubinak focus on the role of hyper-polymorphic MHCII molecules in the regulation of host-microbiota interactions. Variation in the ability to manage this interaction is emerging as a major contributing factor in the pathogenesis of multiple diseases.
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07/08/2020
Research Article
Zhang and colleagues identify a functional cellular receptor of nervous necrosis virus in red-spotter grouper with potential implications for developing novel strategies against NNV infection.
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07/06/2020
Research Article
In this study, Wilson, Heckendorn and colleagues demonstrate that a protein product named TgPL3, localised to the apical end of T. gondii, has a role in rhoptry secretion, host cell invasion and survival of T. gondii during acute mouse infection.
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07/09/2020
Research Article
Miller, Pasternak & Medeiros et al show that S. Typhimurium produces curli amyloids in the cecum and colon of mice after oral infection. They demonstrate that curli cause an increase in autoimmunity and inflammation in the knee joints of infected mice, and so may be implicated in pathogenesis of reactive arthritis.
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07/08/2020
Research Article
Sieben et al use super resolution microscopy to study the lateral organization of plasma membrane-bound molecules involved in IAV infection, as well as their functional relationship.
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07/07/2020
Research Article
Nguyen & Chávez-Arroyo et al study factors contributing to secretion of IL-10 and immunosuppression after infection with phagosome-confined L. monocytogenes
Image credit: Nathan Reading
07/06/2020
Research Article
Gao et al describe the F. verticillioides transcription response to exposure to pyrrocidines and find that these effectively eliminate fumonisin production in wild F. verticillioides, with potential for development of biocontrol
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07/09/2020
Research Article
vom Steeg et al observe that administration of testosterone to male mice improves the outcome of IAV infection, which may have therapeutic potential in humans.
Image credit: ppat.1008506
A Pearls article by Ludington and Ja
Sandra Silva-Arrieta, Philip J. R. Goulder & Christian Brander
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