July 2, 2019

PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammals

Arai et al.

Image credit: Arai Y, et al. (2019)

Microbes and Host Cell Membrane Interactions

Call for Papers with PLOS Pathogens and PLOS ONE

Submit by Oct 18

07/11/2019

Featured Research

Full atomistic model of prion structure and conversion

Spagnolli et al. have created a very detailed model of PrP^Sc, which includes all its atoms, using computational techniques. The model resembles a 4-rung cork-screw. The model is stable and agrees with all available experimental data on PrP^ScThis structure allowed us to model for the first time the process of prion propagation at high resolution. These data inspire several new hypotheses to elucidate prion biology and design therapeutics for prion diseases

Image credit: Spagnolli G, et al. (2019)

Full atomistic model of prion structure and conversion

Recently Published Articles

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Current Issue June 2019

07/11/2019

Pearls

Amino acid–derived quorum sensing molecules controlling the virulence of vibrios (and beyond)

Here, Defoirdt focuses on three quorum sensing molecules that were recently documented to control the virulence of vibrios: indole, cyclo(L-phenylalanine-L-proline) (cyclo(Phe-Pro)), and 3,5-dimethylpirazin-2-ol (DPO). These quorum sensing molecules share one particular feature—i.e., they are derived from amino acids.

Image credit: Defoirdt T (2019)

Amino acid–derived quorum sensing molecules controlling the virulence of vibrios (and beyond)

07/11/2019

Research Article

Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression

Bachmann et al. show that at the onset of the blood stage in malaria-naïve hosts the parasite population activates a large group of var genes simultaneously, but in individuals with high levels of naturally acquired immunity the var transcript pattern was narrowed to a single or very few PfEMP1 variants compatible with parasite survival in the face of host immunity.

Image credit: Bachmann A, et al. (2019)

Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression

07/03/2019

Research Article

Perturbations of the ZED1 pseudokinase activate plant immunity

Bastedo et al. propose that effector-induced interactions between ZED1/ZRK pseudokinases (RLCK family XII) and PBL kinases (RLCK family VII) provide a sensitive mechanism for detecting perturbations of either kinase family to activate ZAR1-mediated ETI.

Image credit: Bastedo DP, et al. (2019)

07/01/2019

Research Article

Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner

Sharma et al. demonstrate that the macaque interferon-induced transmembrane proteins (IFITMs) selectively restrict replication of unadapted SHIVs. These findings may help develop new approaches to improve the SHIV/macaque model of HIV-1 infection.

Image credit: Sharma A, et al. (2019)

07/01/2019

Research Article

HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells

Hyun et al.'s data demonstrates that blocking TREM1 expression reduces inflammatory responses mediated by HIV or HCV stimulation. Ultimately, their understanding of this mechanism may yield additional therapeutic strategies to help infected patients and give insight into inflammation driven liver cancer.

Image credit: Hyun J, et al. (2019)

07/01/2019

Research Article

Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)

Tuju et al.

Image credit: Tuju J, et al. (2019)

06/27/2019

Research Article

Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus

Walsh et al.

Image credit: Walsh NM, et al. (2019)

06/21/2019

Research Article

The YIN and YANG of lipoproteins in developing and preventing infectious arthritis by Staphylococcus aureus

Mohammad and colleagues

Image credit: Mohammad M, et al. (2019)

06/26/2019

Research Article

Enteropathogenic Escherichia coli remodels host endosomes to promote endocytic turnover and breakdown of surface polarity

Kassa et al.

Image credit: Kassa EG, et al. (2019)

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PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammals

Microbes and Host Cell Membrane Interactions

Call for Papers with PLOS Pathogens and PLOS ONE

Full atomistic model of prion structure and conversion

Recently Published Articles

Amino acid–derived quorum sensing molecules controlling the virulence of vibrios (and beyond)

Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression

Perturbations of the ZED1 pseudokinase activate plant immunity

Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner

HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells

Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)

Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus

The YIN and YANG of lipoproteins in developing and preventing infectious arthritis by Staphylococcus aureus

Enteropathogenic Escherichia coli remodels host endosomes to promote endocytic turnover and breakdown of surface polarity

Intestinal serum amyloid a suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization

Comparison of the human gastric microbiota in hypochlorhydric states

CagA induced dysbiosis promotes epithelial cell proliferation in the Drosophila gut

The microbiome and the hallmarks of cancer

Prion acute synaptotoxicity is largely driven by protease-resistant PrP^Sc species

Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β

Identification of virus-encoded microRNAs in divergent Papillomaviruses

Inhibition of murine herpesvirus-68 replication by IFN-gamma in macrophages is counteracted by the induction of SOCS1 expression

A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors

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Microbes and Host Cell Membrane Interactions

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Recently Published Articles

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