September 19, 2018
Image credit: Guan H, et al. (2018)
09/20/2018
featured research
A non-pathogenic fungus can expand in the intestines of antibiotic-treated mice and enhance the severity of allergic airways disease, according to this PLOS Pathogens Featured Research article by Underhill and colleagues.
Image credit: Skalski JH, et al. (2018)
Current Issue August 2018
09/20/2018
featured research
The ability to acquire manganese during infection is essential for the virulence of E. faecalis in animals, according to this article by Lemos and colleagues. The authors identify major manganese acquisition systems of this opportunistic pathogen.Their findings suggest that these transporters are essential for the growth of E. faecalis in manganese-restricted environments.
Image credit: Photo by Nathan Shankar, digital colorization by Stephen Ausmus. United States Department of Agriculture, 2009.
09/20/2018
pearls
Inflammatory bowel disease (IBD) refers to a group of chronic inflammatory diseases that affect the gastrointestinal tract and includes ulcerative colitis and Crohn’s disease (CD). Cadwell and Wong review the myriad microbes that have been interrogated in patients and laboratory models for their roles in IBD pathogenesis, highlighting the central importance of understanding host-microbe interactions. They discuss infectious triggers and gene-microbe interactions.
Image credit: Wong S-Y, Cadwell K (2018)
09/20/2018
pearls
Precise coordination of cellular processes requires prompt specification of protein function in response to various stimuli. Mehle and Dawson use influenza virus and its proteins as exemplars for how PTMs impact virus replication.
Image credit: Dawson AR, Mehle A (2018)
09/20/2018
pearls
Celiac disease (CD) is an autoimmune enteropathy that occurs in genetically susceptible individuals exposed to dietary gluten. CD occurs in approximately 1 in 133 persons in the United States. Dermody and colleagues assess the relationship between viruses and CD, including how some reovirus strains break oral tolerance. However they note that not all reovirus strains induce tolerance loss.
Image credit: Brown JJ, Jabri B, Dermody TS (2018)
09/20/2018
research article
Harris and colleagues' results provide powerful insights into the biology of prion neurotoxicity, they identify new, druggable therapeutic targets, and they allow comparison of prion synaptotoxic pathways with those involved in other neurodegenerative disorders like Alzheimer’s disease.
Image credit: Fang C, et al. (2018)
09/17/2018
research article
Image credit: Rosenberg BR, et al. (2018)
09/19/2018
Research Article
Image credit: Ahmed A, et al. (2018)
09/18/2018
Research Article
Image credit: Mingorance L, et al. (2018)
09/20/2018
Research article
Image credit: Cohen C, et al. (2018)
PLOS Pathogens invites submission of your research on the microbiome (of animals, plants, and humans) and its interactions with infectious disease or the immune system.
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