November 16, 2020
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11/19/2020
Pearls
This Pearls article by Brown and Garsin seeks to shed light on cardiac microlesion formation as a possible risk factor for adverse cardiac complications during severe bacterial infection and the underlying mechanisms contributing to this newly described pathology.
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Current Issue October 2020
11/19/2020
Pearls
Rotavirus vaccine efficacy is significantly reduced in lower- and middle-income countries compared to high-income countries. This review by Otero et al summarizes current research into the mechanisms behind this phenomenon, with a particular focus on the evidence that maternal antibody interference is a contributing factor to this disparity.
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11/12/2020
Pearls
The infectious hypothesis proposes that a pathogen is the root cause of Alzheimer disease. Seaks and Wilcock discuss the evidence supporting this hypothesis, highlighting what is currently known about herpesvirus and it's potential contributions to AD.
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11/20/2020
Research Article
Findings by Zhou and colleagues demonstrate that calcineurin is a critical host cell factor pivotal in the regulation of VZV induced cell fusion, which is essential for VZV pathogenesis. This provides a new perspective for potential antiviral strategies that target host factors.
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11/20/2020
Research Article
Badgujar, Anil and Green et al uncover the structural basis for loss of pore-forming activity of a pneumolysin variant and observe that this enabled adoption of an intracellular lifestyle, attenuating inflammatory responses and prolonging host tolerance of pneumococcus in the lower airways.
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11/19/2020
Research Article
Müller and colleagues use genetic sequence data and patient information to better understand local spread of influenza by looking at the 2016/2017 flu season in Basel, Switzerland. Analyses suggest that the elderly mainly transmit within their own transmission network and that school aged children are important drivers of the local spread of influenza.
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11/24/2020
Research Article
Mahyari & Taher et al characterise a recombinant rhesus cytomegalovirus containing a complete genome in vitro and in vivo.
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11/24/2020
Research Article
Ekanayaka and Lee et al find that the Foot-and-Mouth disease virus capsid protein VP1 targets the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation.
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11/24/2020
Research Article
Karina Diaz and colleagues show that defensins can drive the evolution of non-enveloped viruses. Furthermore, they identify important components within human adenovirus that dictate sensitivity to defensins.
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11/12/2020
Research Article
Chabrolles et al shed new light on the novel regulatory functions of HBV core protein with new insights relevant for the development of potential antiviral strategies.
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A Pearls article by Ludington and Ja
Margarida Sa Ribero, Nolwenn Jouvenet, Marlène Dreux & Sébastien Nisole
Sandra Silva-Arrieta, Philip J. R. Goulder & Christian Brander
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