May 3, 2021
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05/06/2021
Pearls
Chen & Zhou et al discuss the synergy between H. pylori and C. albicans in gastric diseases and discuss their interactions with gastrointestinal flora. The cross-kingdom interactions of these pathogens could be a new target for the prevention, diagnosis, and treatment of H. pylori infection.
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Current Issue April 2021
04/22/2021
review
The release of “Open Access Boxes” is an initiative launched by Medicines for Malaria Venture (MMV) in collaboration with its partners to catalyze new drug discovery in neglected diseases. Here, Kirandeep Samby and colleagues present guidelines on how to move actives beyond the hit identification stage, to help in capacity strengthening and enable a greater impact of the initiative.
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04/29/2021
Opinion
This article from Connor Bamford highlights a recent paper from Ju and colleagues in which they generate a novel reagent, so-called trVLPs, or transcription and replication competent virus-like particles, to identify SARS-CoV-2 antivirals outside of Biosafety Level 3 conditions.
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05/06/2021
Research Article
Alyssa Walker and colleagues suggest that gut bacteria directly contribute to the pathogenicity of protein conformational neurodegenerative disease.
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04/28/2021
Research Article
Findings from He & Li et al elucidate FMDV neutralization by hosts and provide epitope information for vaccine development against FMDV.
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04/27/2021
Research Article
Bertram & Truong et al hypothesize that the uptake of HSV and infection of Epi-cDC2s will stimulate immune responses via a different pathway to Langerhans cells, which in future may help guide HSV vaccine development and adjuvant targeting.
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04/29/2021
RESEARCH ARTICLE
Ziegler et al create a primary nasopharyngeal three-dimensional air-liquid interface cell culture model of the pseudostratified epithelium reveals differential donor- and cell type-specific susceptibility to Epstein-Barr virus infection.
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05/06/2021
Research Article
Lin et al show that sensory neurons regulate corneal neutrophil responses in a tissue-specific matter affecting disease progression during P. aeruginosa keratitis.
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05/06/2021
Research Article
Hui et al unravel a novel role of EVs as vehicles transmitting antigens to induce Th1-type immunity against Gram-negative bacteria.
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04/29/2021
Research Article
Eichner et al show that both S. pneumoniae and H. influenzae evade defensive mechanisms of the innate immune system by sensing body temperature.
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