May 5, 2022
Image credit: My-Hang Huynh
05/12/2022
Review
In this Review, Koszalka and colleagues summarize preclinical and clinical advances in combination therapy for the treatment of influenza with reference to immunocompromised animal models and clinical data in hospitalized patient cohorts where available. They include polymerase inhibitors, monoclonal antibodies (mAbs), host-targeted therapies, and adjunctive therapies.
Image credit: Prawny, Pixabay
Current IssueJune 2022
05/19/2022
Pearls
In this Pearls article, Gaspar and Pawlowska outline the convergently evolved innate immune modules of animals and plants, argue that antibacterial defenses of fungi exhibit hallmarks of innate immunity, explore the types of RCD in fungi, hypothesize that RCD is one of the defensive responses in fungi, present a model system to test this hypothesis, and consider the significance of such research for developing novel antifungal therapies.
Image credit: ppat.1010460
05/05/2022
Review
In this Review, Ander and colleagues summarize what is known of the recognition and capture of virions from the circulation prior to the generation of a specific antibody response, and the consequences of viral capture on viral pathogenesis and the fate of the captor cell.
Image credit: ppat.1010474
04/21/2022
Research Article
Gibson and colleagues study how Cryptococcus neoformans infection may lead to vessel damage and associated pathogen dissemination using a zebrafish model. They suggest that global vascular vasodilation occurs following infection, resulting in increased vessel tension which then increases dissemination events.
Image credit: Zhaklin Chalakova and Simon Johnston
04/21/2022
Research Article
Shmeleva and colleagues find that intradermal vaccination with vaccinia virus induces a large increase in the number of commensal bacteria in infected tissue, which enhance recruitment of inflammatory cells, promote tissue damage and influence the host response.
Image credit: ppat.1009854
04/28/2022
Research Article
Chandra and colleagues make chromosomal deletions of the chitinase encoding gene (chiA) to study the role of chitinase of Salmonella enterica in the pathogenesis of the serovars, Typhimurium, and Typhi.
Image credit: ppat.1010407
04/28/2022
Research Article
From Nitin Hingankar & Suprit Deshpande and colleagues.
Image credit: ppat.1010465
04/22/2022
Research Article
From Virginia Hargest and colleagues
Image credit: ppat.1009716
04/21/2022
Research Article
From Patricia Bartsch and colleagues.
Image credit: ppat.1010430
04/20/2022
Research Article
From Koen K. A. Van Rompay and colleagues.
Image credit: dendoktoor, Pixabay
Frideborg Bradley and colleagues
Jodie A. Schiffer & Stephanie V. Stumbur and colleagues
B. Karina Montero and colleagues
Andrea Martinez Aguirre and colleagues
Yi Gong and colleagues
Shunmugam, Arnold, and colleagues
Mouat and Horwitz
Strine and Wilen
Mittal and colleagues
Hassan and Blanchard
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