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Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice

March 14, 2019

Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice

Featured Research from De Chiara et al. 

Image credit: De Chiara G, et al.

03/11/2019

Research Article

The fungal ribonuclease-like effector protein CSEP0064/BEC1054 represses plant immunity and interferes with degradation of host ribosomal RNA

Powdery mildews are common plant diseases which affect important crop plants including cereals such as wheat and barley.Pennington et al. propose a novel mechanism of action for the RNase-like effectors in powdery mildews: they may act as pseudoenzymes to inhibit the host RIPs, known components of plant immune responses that lead to cell death.

Image credit: Pennington HG, et al. (2019)

The fungal ribonuclease-like effector protein CSEP0064/BEC1054 represses plant immunity and interferes with degradation of host ribosomal RNA

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Current Issue February 2019

03/14/2019

Research Article

The small non-coding RNA RsaE influences extracellular matrix composition in Staphylococcus epidermidis biofilm communities

Schoenfelder et al. speculate that RsaE-mediated bacterial lysis might represent a form of bacterial altruism contributing to biofilm structuring by providing nutrients to neighboring bacterial cells as well as by releasing eDNA as stabilizing biofilm matrix component. Together, the data give insight into an unanticipated role of sRNAs as players in S. epidermidis biofilm organization. 

Image credit: Schoenfelder SMK, et al.

The small non-coding RNA RsaE influences extracellular matrix composition in Staphylococcus epidermidis biofilm communities

03/14/2019

Research Article

Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8+ T cell effector function

Jones et al. 's results indicate that blocking PD-L1 expression during varicella or zoster may restore CD8+ T cell effector function. , enabling effective clearance of virus-infected cells to reduce viral spread and multisystem disease.

Image credit: Jones D, et al.

Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8+ T cell effector function

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