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The cellular phenotype of cytoplasmic incompatibility in Culex pipiens in the light of cidB diversity

October 15, 2018

The cellular phenotype of cytoplasmic incompatibility in Culex pipiens in the light of cidB diversity

Sicard et al. 

Image credit: Bonneau M, et al. (2018)

Publishing Dual Use Research of Concern: A Case Study

New Collection from PLOS Pathogens

DURC Collection

10/18/2018

featured RESEARCH 

Independent amplification of co-infected long incubation period low conversion efficiency prion strains

Eckland et al. hypothesize the abundance of PrPC is not limiting in vivo or in vitro resulting in prion strains with relatively low prion conversion efficiency. Overall, this observation changes the paradigm of the interactions of prion strains and has implications for interspecies transmission and emergence of prion strains from a mixture. 

Image credit: Eckland TE, et al. (2018)

Independent amplification of co-infected long incubation period low conversion efficiency prion strains

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Current Issue

Current Issue September 2018

10/18/2018

pearl

Pathogen-based precision medicine for drug-resistant tuberculosis

Gröschel et al. discuss the implementation of next generation sequencing techniques, such as whole-genome sequencing (WGS), in tuberculosis (TB). Research has enabled timely, cost-effective, and comprehensive insights into the genetic repertoire of the human pathogens of the Mycobacterium tuberculosis complex (MTBC).

Image credit: Gröschel MI, et al. (2018)

Pathogen-based precision medicine for drug-resistant tuberculosis

10/18/2018

Review

Secreted venom allergen-like proteins of helminths: Conserved modulators of host responses in animals and plants

Wilbers et al.'s review tackles venom allergen-like proteins (VALs). Although the habitats of animal- and plant-parasitic helminths are very distinct, their secretions share the presence of a structurally conserved group of proteins called VALs. Improved knowledge on VAL biological functions may assist in designing novel protection strategies against parasites. 

Image credit: Wilbers RHP, et al. (2018)

Secreted venom allergen-like proteins of helminths: Conserved modulators of host responses in animals and plants

10/17/2018

research article

Microevolution in response to transient heme-iron restriction enhances intracellular bacterial community development and persistence

Mason et al. hypothesize that strains adapted to survive nutrient deprivation are more adept for colonization and establishment of chronic infection.The authors' data provide the first insight into NTHI microevolution during nutritional limitation and provide the first demonstration of IBCs in a preclinical model of chronic OM.

Microevolution in response to transient heme-iron restriction enhances intracellular bacterial community development and persistence

Image credit: Hardison RL, et al. (2018)

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