Born to sweet delight: Using natural models of malaria protection to understand and neutralize P. falciparum pathogenesis

Ji et al. reveal the molecular basis of GBP-IpaH9.8 interaction, and show that subtle differences in the seven human GBPs can significantly impact the targeting specificity of IpaH9.8. Their results provide important  insights into S. flexneri pathogenesis. 

Pickering et al. demonstrate that a canine host-restricted bacterial pathogen, Staphylococcus pseudintermedius, produces a surface protein (SpsL) that has the ability to preferentially bind to canine fibrinogen with high strength. 

 Soares-Schanoski et al. provide a detailed picture of the early molecular events induced by CHIKV infection. Additionally, the systems biology approach reveals genes that can be investigated extensively as probable therapeutic targets for the disease.