Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes
Antigenic variation by variant surface glycoprotein (VSG) coat switching in African trypanosomes is one of the most elaborate immune evasion strategies found among pathogens. McCulloch et al. discuss the evidence that underpins these switch-initiation models and consider what features and mechanisms might be shared or might allow the models to be tested further.
Image credit: da Silva MS, et al. (2018)