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Publishing Dual Use Research of Concern: A Case Study

New Collection from PLOS Pathogens

DURC Collection

11/15/2018

Review

Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes

Antigenic variation by variant surface glycoprotein (VSG) coat switching in African trypanosomes is one of the most elaborate immune evasion strategies found among pathogens. McCulloch et al. discuss the evidence that underpins these switch-initiation models and consider what features and mechanisms might be shared or might allow the models to be tested further.

Image credit: da Silva MS, et al. (2018)

Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes

Recently Published Articles

Current Issue

Current Issue October 2018

11/15/2018

Pearl

Infection of anopheline mosquitoes with Wolbachia: Implications for malaria control

Recently, traces of Wolbachia genomic DNA were identified in a microbiome survey of the reproductive organs of A. gambiae and A. coluzzii in malaria-endemic areas of Burkina Faso in West Africa. Gomes and Mury highlight recent studies that suggest that there is a threshold level of Wolbachia infection in mosquitoes above which malaria transmission would no longer be effective.

Image credit: Gomes FM, Barillas-Mury C (2018)

Infection of anopheline mosquitoes with Wolbachia: Implications for malaria control

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