Independent amplification of co-infected long incubation period low conversion efficiency prion strains
Eckland et al. hypothesize the abundance of PrPC is not limiting in vivo or in vitro resulting in prion strains with relatively low prion conversion efficiency. Overall, this observation changes the paradigm of the interactions of prion strains and has implications for interspecies transmission and emergence of prion strains from a mixture.
Image credit: Eckland TE, et al. (2018)