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Broad protective vaccination against systemic Escherichia coli with autotransporter antigens

February 17, 2023

Broad protective vaccination against systemic Escherichia coli with autotransporter antigens

This study identified a surface-exposed, pathogen-specific autotransporter protein, SinH, as a potential vaccine candidate for E. coli infection.

Image credit: Hawaii Dept. of Health

Read the latest Reviews in PLOS Pathogens

Peer-reviewed articles on topical areas of broad interest to the pathogens community.

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04/03/2023

Research Article

Evolutionary dynamics of dengue virus in India

More than a hundred thousand dengue cases are diagnosed in India annually, and about half of the country’s population carries dengue virus-specific antibodies. Dengue propagates and adapts to the selection pressures imposed by a multitude of factors that can lead to the emergence of new variants. Yet, there has been no systematic analysis of the evolution of the dengue virus in the country.

Evolutionary dynamics of dengue virus in India

Image credit: Roy et al

04/03/2023

Research Article

Naturally occurring substitution of an amino acid in a plant virus gene-silencing suppressor enhances viral adaptation to increasing thermal stress

Cereal yellow dwarf virus (CYDV-RPV) encodes a P0 protein that functions as a viral suppressor of RNA silencing (VSR). In this study, comparison of the P0 sequences of CYDV-RPV isolates and mutational analysis identified a single C-terminal amino acid that influenced P0 RNA-silencing suppressor activity.

Naturally occurring substitution of an amino acid in a plant virus gene-silencing suppressor enhances viral adaptation to increasing thermal stress

Image credit: Amit Lahav

04/06/2023

Pearls

Cell death as a defense strategy against pathogens in plants and animals

Eukaryotes are endowed with sophisticated innate immune systems to recognize non-self and halt pathogen proliferation. Activation of cell death at the site of attempted pathogen ingress is a common strategy used by plants and animals to restrict pathogen proliferation and trigger immune responses in the surrounding tissues. As such, immunogenic cell death shares several traits in plants and animals

Cell death as a defense strategy against pathogens in plants and animals

Image credit: National Cancer Institute

02/23/2023

Pearls

The Cryptococcus wall: A different wall for a unique lifestyle

This review from Dr. Liliane Mukaremera aims to assess new insights into the unique attributes about the Cryptococcus cell wall in relation to the pathogenic lifestyle of these important pathogens

The Cryptococcus wall: A different wall for a unique lifestyle

Image credit: Wikipedia/Nephron

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PLOS Pathogens | ISSN: 1553-7374 (online)