06/16/2025
research article
In this study, the authors isolate EVs from Toxoplasma gondii-infected murine neurons and find that cyst infection reduces EV production and alters their host protein and miRNA content.
Image credit: ppat.1012733
Current Issue June 2025
06/05/2025
research article
Here, the authors show that tunnelling nanotube-like structures are formed by influenza A virus-infected cells in vivo, and use in vitro models to ask how IAVs induce their formation. They find that TLS formation requires intracellular viral replication and correlates with apoptosis, which in turn promotes direct cell-to-cell viral spread.
Image credit: ppat.1013191
05/30/2025
research article
Here, the authors utilize a genome-wide CRISPR-Cas9-based screen to identify TMEM198 as a critical host protein for double-membrane vesicle (DMVs) formation during the replication of swine alphacoronavirus.
Image credit: ppat.1013211
06/09/2025
research article
Here, the authors screen wastewater sequencing data from public databases to detect 18 cryptic SARS-CoV-2 lineages, including 12 not previously reported, and characterize convergent mutations that appear to revert to residues conserved in bat Sarbecoviruses.
Image credit: ppat.1012850
05/30/2025
research article
In this study, the authors investigate how host macrophages respond to extracellular vesicles produced by different fungal pathogens. They find that surface structures on these vesicles affect macrophage uptake and downstream immune activation, revealing species-specific differences in host-pathogen interactions.
Image credit: ppat.1012879
06/04/2025
research article
This study elucidates the molecular function of Tse4, a T6SS effector that promotes membrane depolarization in competing bacteria by forming ion-selective channels that drive K⁺ efflux.
Image credit: ppat.1012981
06/04/2025
research article
This study shows that the tegument of the model cestode Mesocestoides corti is sensitive to albendazole, which disrupts microtubules and reduces global protein synthesis.
Image credit: ppat.1013221
06/09/2025
research article
This study explores how CD4+ T cells control M. tuberculosis via MHCII-driven macrophage activation.
Image credit: ppat.1013208
06/12/2025
research article
Here, the authors use atomic force microscopy (AFM) to investigate how reverse transcription progression and genome length influence HIV-1 core elasticity and disassembly.
Image credit: ppat.1013269
06/16/2025
research article
This study identifies a novel interaction between IFI27, PACT and PKR that enhances PKR activation and reduces protein translation during RNA virus infection.
Image credit: ppat.1013246
Brittany Seibert, C. Joaquín Cáceres, and colleagues
Qi-Yue Yang, Yong-Le Yang, and colleagues
Frideborg Bradley and colleagues
Jodie A. Schiffer & Stephanie V. Stumbur and colleagues
B. Karina Montero and colleagues
We are pleased to announce that Sumita Bhaduri-McIntosh joined us as second Editor-in-Chief at the beginning of 2025. With this addition, we are thrilled to once again have a dynamic dual leadership team guiding the journal.
We're excited about our revised and synchronized Editorial Board webpage—now enhanced with a brand-new search functionality!
Easily find and explore board members with our improved layout and seamless navigation.
We've been thrilled to welcome:
Helena Boshoff, Thomas Guillard, Thomas Hoenen, Francis Jiggins, Robert Kalejta, Tracey Lamb, Edward Mitre, and Alice Prince!
PLOS will always anchor our decisions in our values and our principles. And we will continue to speak up vocally for open, independent science.
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