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12/06/2018

Featured research

Transmission dynamics of re-emerging rabies in domestic dogs of rural China

Despite ongoing efforts to control transmission, rabies prevention remains a challenge in many developing countries, especially in rural areas of China. By taking advantage of detailed genomic and epidemiological data for the re-emerging rabies outbreak in Yunnan Province, China, Tian et al. reconstruct the demographic and dispersal history of domestic dog rabies virus as well as the dynamics of transmission.

Image credit: Tian H, et al. (2018)

Transmission dynamics of re-emerging rabies in domestic dogs of rural China

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Current Issue November 2018

12/06/2018

Featured research

CCR5 structural plasticity shapes HIV-1 phenotypic properties

CCR5 regulates host immune responses against pathogens. It also serves as an anchor for R5-tropic strains of HIV-1 to infect immune cells, hence contributing to development of AIDS. Colin et al. interrogated the significance of the CCR5 structural diversity on HIV-1 infection. Their results support a role for CCR5 heterogeneity in diversifying the phenotypic properties of HIV-1 isolates and provide new clues for development of CCR5-targeting drugs.

Image credit: Colin P, et al. (2018)

CCR5 structural plasticity shapes HIV-1 phenotypic properties

12/06/2018

Pearls

Innate antimicrobial immunity in the skin: A protective barrier against bacteria, viruses, and fungi

Coates et al. review the epidermis, the outermost layer of the skin, which is a physical barrier against pathogens. However, breach of the skin barrier through wounding introduces a myriad of microbes to the site of injury. Upon disturbance of the epidermal barrier, the innate immune system and its effectors play a key role in protecting humans against cutaneous and systemic infection. 

Image credit: Coates M, et al. (2018)

Innate antimicrobial immunity in the skin: A protective barrier against bacteria, viruses, and fungi

12/06/2018

Pearls

Is sex necessary for the proliferation and transmission of Pneumocystis?

The life cycle of Pneumocystis remains elusive as a consequence of the absence of the inability to propagate them outside of the mammalian lung. However, comparative genomics, transcriptomal, and whole-genome analyses recently brought crucial new insights into the Pneumocystis life cycle. Hauser and Cushion update the life cycle in light of these new findings. 

Is sex necessary for the proliferation and transmission of Pneumocystis?

Image credit: Hauser PM & Cushion MT (2018)

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