Plasmodium sporozoites induce regulatory macrophages

Jin & Mwimanzi et al demonstrate that the SERINC antagonism activities of HIV Nef differ markedly among major viral subtypes and between individual isolates within a subtype, suggesting that variation in these functions may contribute to global differences in viral pathogenesis.

Geoffrey Vrla and colleagues use a microscopy-based host-cell killing assay to show that the alkyl-quinolone (AQ) family of secreted small molecules is both necessary and sufficient to explain surface-induced virulence. These compounds are found to be upregulated rapidly following bacterial surface attachment.

Harrison and colleagues show that the immune antagonist P-protein of diverse pathogenic lyssaviruses inhibits responses activated by interleukin-6 family cytokines, critical players in inflammatory responses, via targeting of the host transcription factor STAT3.