07/22/2021
Review
Current understanding of antibody-independent B cell functions in acute and chronic viral infections and their role in protection and/or immunopathogenesis is limited.
Upasani and colleagues summarize the current literature on these antibody-independent B cell functions and identify remaining knowledge gaps.
Image credit: ppat.1009708
Current Issue June 2021
07/22/2021
Review
In this Review, Jürgen Krücken and colleagues discuss the potential of Emodepside as an anthelmintic candidate for the treatment of onchocerciasis, and highlight current progress in clinical trials.
Image credit: ppat.1009682
07/22/2021
Pearls
In this Pearls article, Rebeca Alonso-Monge and colleagues review recent studies that demonstrate both beneficial and detrimental effects of this pathobiont Candida albicans to human health upon colonization of the human gut.
Image credit: ppat.1009710
07/16/2021
Research Article
Results from Nidhi Shukla and colleagues provide improved quantitative understanding for how ACE2 sequence and abundance correlate with infectivity, with implications for how natural human ACE2 variants, or variants observed in related species, may impact susceptibility to infection.
Image credit: ppat.1009715
07/16/2021
Research Article
In this study, Hengzhi Sh and colleagues investigate the role of a key gene acox-1, in the larval development of Haemonchus contortus, one of the most important parasitic nematodes that employ hypobiosis as a routine survival mechanism.
Image credit: ppat.1009767
07/19/2021
Research Article
Zhao-Hua Zhou and colleagues evaluate the timing of anti SARS-CoV-2 antibody production in hospitalized patients with the use of a highly sensitive multiplexed bead-based immunoassay allowing for early detection of antibodies to SARS-CoV-2.
Image credit: ppat.1009766
07/21/2021
Research Article
Jin-Tao Zou and colleagues discover that pore-forming alpha-hemolysin efficiently improves the immunogenicity and protective efficacy of protein antigens.
Image credit: ppat.1009752
07/16/2021
Research Article
Boppana, Qin & Files et al find that SARS-CoV-2-specific circulating T follicular helper cells correlate with neutralizing antibodies and increase during early convalescence.
Image credit: NIH
07/19/2021
Research Article
Nomura et al demonstrate that subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques.
Image credit: NIAID
07/19/2021
Research Article
Grigoryeva & Cianciotto show that human macrophages utilize a range of pathogen recognition receptors to recognize Legionella pneumophila, including TLR 4 engaging Legionella lipopolysaccharide and the Toll-like Receptor 3 nucleic-acid sensor.
Image credit: ppat.1009781
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