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Microbiome Across Biological Systems Call for Papers!

A Cross-Journal Call for Papers by PLOS ONE, PLOS Biology, and PLOS Pathogens

Submit by Aug 6

04/25/2019

Pearls 

The ABCs of wheeze: Asthma and bacterial communities

Asthma is a common respiratory illness affecting approximately 8% of Americans and is characterized by symptoms of wheeze, cough, and shortness of breath. However, the role played by the body’s endogenous microbial communities (microbiota) has emerged as a new component to this puzzle. Kau et al. discuss how microbial community dynamics promote allergy susceptibility and the potential for microbiota-directed therapeutics in asthma. 

Image credit: Wilson NG, et al. (2019)

The ABCs of wheeze: Asthma and bacterial communities

Recently Published Articles

Current Issue

Current Issue March 2019

04/22/2019

Research Article

Twin arginine translocation, ammonia incorporation, and polyamine biosynthesis are crucial for Proteus mirabilis fitness during bloodstream infection

The Gram-negative bacterium Proteus mirabilis is a common cause of catheter-associated urinary tract infections (CAUTI), which can progress to secondary bacteremia. Armbruster et al.'s studies indicate a role for the twin arginine translocation (tatAC) system in motility, translocation of potential virulence factors, and fitness within the bloodstream.

Image credit: Armbruster CE, et al. (2019)

Twin arginine translocation, ammonia incorporation, and polyamine biosynthesis are crucial for Proteus mirabilis fitness during bloodstream infection

04/22/2019

Research Article

Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target

Staphylococcus aureus is becoming increasingly difficult  to treat due to antibiotic resistance. Lacey et al.'s study reveal a novel role for ClfB during SSTIs. ClfB is crucial in determining the abscess structure and bacterial burden early in infection and this is dependent upon specific interaction with the ligand loricrin which is expressed within the abscess tissue.

Image credit: Lacey KA, et al. (2019)

Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target

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