The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence

The life cycle of Pneumocystis remains elusive as a consequence of the absence of the inability to propagate them outside of the mammalian lung. However, comparative genomics, transcriptomal, and whole-genome analyses recently brought crucial new insights into the Pneumocystis life cycle. Hauser and Cushion update the life cycle in light of these new findings. 

Antibodies are the humoral component of an immune response against an invading pathogen or vaccine immunogen. Welles et al.'s study demonstrates feasibility of a gene therapy-based passive immunization strategy against infectious disease. 

Previous studies show that T. gondii encodes a pore-forming protein, TgPLP1, which contains an unusual domain that is crucial for efficient exit from both the parasite-containing vacuole and the host cell. Guerra et al. sheds light into the determinants of membrane binding in TgPLP1.