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Microbes and Host Cell Membrane Interactions

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Submit by Oct 18

07/11/2019

Featured Research

Full atomistic model of prion structure and conversion

Spagnolli et al. have created a very detailed model of PrPSc, which includes all its atoms, using computational techniques. The model resembles a 4-rung cork-screw. The model is stable and agrees with all available experimental data on PrPSc This structure allowed us to model for the first time the process of prion propagation at high resolution. These data inspire several new hypotheses to elucidate prion biology and design therapeutics for prion diseases

Image credit: Spagnolli G, et al. (2019)

Full atomistic model of prion structure and conversion

Recently Published Articles

Current Issue

Current Issue June 2019

07/11/2019

Research Article

Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression

Bachmann et al. show that at the onset of the blood stage in malaria-naïve hosts the parasite population activates a large group of var genes simultaneously, but in individuals with high levels of naturally acquired immunity the var transcript pattern was narrowed to a single or very few PfEMP1 variants compatible with parasite survival in the face of host immunity.

Image credit: Bachmann A, et al. (2019)

Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression

07/03/2019

Research Article

Perturbations of the ZED1 pseudokinase activate plant immunity

Bastedo et al. propose that effector-induced interactions between ZED1/ZRK pseudokinases (RLCK family XII) and PBL kinases (RLCK family VII) provide a sensitive mechanism for detecting perturbations of either kinase family to activate ZAR1-mediated ETI.

Perturbations of the ZED1 pseudokinase activate plant immunity

Image credit: Bastedo DP, et al. (2019)

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