August 29, 2022
Image credit: ppat.1010745
07/28/2022
Review
In this Review, Dolnik and Becker review the current knowledge on the structure, assembly, and transport of filovirus nucleocapsids from their assembly site in inclusion bodies to the budding sites at the plasma membrane, where they are packaged into filamentous infectious virions.
Image credit: ppat.1010616
Current Issue September 2022
07/21/2022
Review
In this Review, Focarelli et al. explain the diverse roles of copper in the human body focusing on the immune system. They also describe how bacterial pathogens respond to the copper toxicity experienced within the host during infection, via both conserved copper homeostasis and detoxification systems in bacteria and species-specific adaptations that are important to pathogenicity.
Image credit: Alexa, Pixabay
07/28/2022
Pearls
In this Pearls article, Ölander and Sixt summarize developments in genetics tools for obligate intracellular bacteria, with a focus on Chlamydia spp., along with a brief overview for others. They also provide examples of insights into chlamydial biology enabled by the expanded toolbox.
Image credit: ppat.1010669
07/21/2022
Research Article
Piepenbrink & Park et al. show that an S2-specific monoclonal antibody can protect from various SARS-CoV-2 viruses, as well as SARS-CoV, including when delivered directly into the nose of animals.
Image credit: Public Health Image Library, CDC
07/25/2022
Research Article
Van Dis et al. delineate a novel, IFN-γ-independent pathway for CD4 T cell-mediated control that begins with production of GM-CSF and leads to HIF-1α activation to restrict M. tuberculosis in infected macrophages.
Image credit: ppat.1010721
07/18/2022
Research Article
Santoni et al. screen several microbial species for the capacity to overcome neutrophil resistance to Caspase-1-driven pyroptosis, and show that the bacterium Pseudomonas aeruginosa specifically engages the NLRC4 inflammasome to promote Caspase-1-dependent Gasdermin D activation and subsequent neutrophil pyroptosis.
Image credit: ppat.1010305
07/25/2022
Research Article
From Maud Thierry and colleagues.
Image credit: ppat.1010687
07/21/2022
Research Article
From Gonzalo Almanza and colleagues.
Image credit: ppat.1010686
07/19/2022
Research Article
From Zihao Pan and colleagues.
Image credit: ppat.1010710
07/18/2022
Research Article
From Neil Bate and colleagues.
Image credit: ppat.1010733
Qi-Yue Yang, Yong-Le Yang, and colleagues
Frideborg Bradley and colleagues
Jodie A. Schiffer & Stephanie V. Stumbur and colleagues
B. Karina Montero and colleagues
Andrea Martinez Aguirre and colleagues
Furlong-Silva & Cook
Cohen et al.
Simantov & Goyal et al.
Graham F. Hatfull
Files & Tacke et al.
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