Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection
Enterohemorrhagic Escherichia coli (EHEC), a food-borne pathogen that produces Shiga toxin. Balasubramanian et al. show that sufficient Shiga toxin was produced to cause lethal mouse disease, even without viral replication, potentially directing intervention strategies.
Image credit: Balasubramanian S, et al. (2019)