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Early and mid-gestation Zika virus (ZIKV) infection in the olive baboon (Papio anubis) leads to fetal CNS pathology by term gestation

August 15, 2022

Early and mid-gestation Zika virus (ZIKV) infection in the olive baboon (Papio anubis) leads to fetal CNS pathology by term gestation

A new research article from Sunam Gurung and colleagues. 

Image credit: ppat.1010386

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Current Issue August 2022

07/11/2022

Research Article

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

Ginex et al. identify key molecular-level differences conferred by the A222V Spike protein mutation that potentially explain its repeated emergence in different genetic backgrounds. Their results point to subtle changes in the dynamic behavior of the receptor-binding domain in the binding-competent "up" conformation.

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

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PLOS Pathogens | ISSN: 1553-7374 (online)