November 14, 2018

Characterization of Haartman Institute snake virus-1 (HISV-1) and HISV-like viruses—The representatives of genus hartmanivirus, family Arenaviridae

Hepojoki et al.

Image credit: Hepojoki J, et al. (2018)

Publishing Dual Use Research of Concern: A Case Study

New Collection from PLOS Pathogens

DURC Collection

11/15/2018

Review

Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes

Antigenic variation by variant surface glycoprotein (VSG) coat switching in African trypanosomes is one of the most elaborate immune evasion strategies found among pathogens. McCulloch et al. discuss the evidence that underpins these switch-initiation models and consider what features and mechanisms might be shared or might allow the models to be tested further.

Image credit: da Silva MS, et al. (2018)

Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes

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Current Issue October 2018

11/15/2018

Pearl

Infection of anopheline mosquitoes with Wolbachia: Implications for malaria control

Recently, traces of Wolbachia genomic DNA were identified in a microbiome survey of the reproductive organs of A. gambiae and A. coluzzii in malaria-endemic areas of Burkina Faso in West Africa. Gomes and Mury highlight recent studies that suggest that there is a threshold level of Wolbachia infection in mosquitoes above which malaria transmission would no longer be effective.

Image credit: Gomes FM, Barillas-Mury C (2018)

Infection of anopheline mosquitoes with Wolbachia: Implications for malaria control

11/15/2018

research article

An aromatic amino acid and associated helix in the C-terminus of the potato leafroll virus minor capsid protein regulate systemic infection and symptom expression

Xu et al.'s study identifies a short-ordered stretch of amino acids containing a conserved aromatic amino acid in the disordered RTP C-terminus. This structural feature determines efficient long-distance virus movement and symptom expression in a host-dependent manner.

Image credit: Xu Y, et al. (2018)

An aromatic amino acid and associated helix in the C-terminus of the potato leafroll virus minor capsid protein regulate systemic infection and symptom expression

11/13/2018

research article

Whole genome screen reveals a novel relationship between Wolbachia levels and Drosophila host translation

Lehmann et al. provide evidence for Wolbachia-host translation interaction and strengthens our general understanding of the Wolbachia-host intracellular relationship.

Image credit: Grobler Y, et al. (2018)

11/13/2018

Research article

Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration

Zhang and colleagues' findings provide the theoretical and experimental basis for the clinical investigation of sirolimus as an adjunct treatment for severe influenza.

Image credit: Jia X, et al. (2018)

11/12/2018

research article

Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection

Pack et al. highlight the capacity of the CD8⁺ T cell population to retain essential in vivo function despite chronic antigen stimulation and support a model in which CD8⁺ T cell dysfunction plays a negligible role in the ability of Trypanosoma cruzi to persist in mice.

Image credit: Pack AD, et al. (2018)

11/14/2018

research article

Adaptive plasticity in the gametocyte conversion rate of malaria parasites

Schneider et al.

Image credit: Schneider P, et al. (2018)

11/12/2018

research article

Lassa virus activates myeloid dendritic cells but suppresses their ability to stimulate T cells

Baize et al.

Image credit: Schaeffer J, et al. (2018)

11/12/2018

research article

HIV-1 capsids from B27/B57⁺ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state

Berthoux et al.

Image credit: Merindol N, et al. (2018)

11/12/2018

research article

REM1.3's phospho-status defines its plasma membrane nanodomain organization and activity in restricting PVX cell-to-cell movement

Mongrand et al.

Image credit: Perraki A, et al. (2018)

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Characterization of Haartman Institute snake virus-1 (HISV-1) and HISV-like viruses—The representatives of genus hartmanivirus, family Arenaviridae

Publishing Dual Use Research of Concern: A Case Study

New Collection from PLOS Pathogens

Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes

Recently Published Articles

Infection of anopheline mosquitoes with Wolbachia: Implications for malaria control

An aromatic amino acid and associated helix in the C-terminus of the potato leafroll virus minor capsid protein regulate systemic infection and symptom expression

Whole genome screen reveals a novel relationship between Wolbachia levels and Drosophila host translation

Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration

Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection

Adaptive plasticity in the gametocyte conversion rate of malaria parasites

Lassa virus activates myeloid dendritic cells but suppresses their ability to stimulate T cells

HIV-1 capsids from B27/B57⁺ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state

REM1.3's phospho-status defines its plasma membrane nanodomain organization and activity in restricting PVX cell-to-cell movement

Prion acute synaptotoxicity is largely driven by protease-resistant PrP^Sc species

Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β

Identification of virus-encoded microRNAs in divergent Papillomaviruses

Inhibition of murine herpesvirus-68 replication by IFN-gamma in macrophages is counteracted by the induction of SOCS1 expression

A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors

Comparison of the human gastric microbiota in hypochlorhydric states

CagA induced dysbiosis promotes epithelial cell proliferation in the Drosophila gut

The microbiome and the hallmarks of cancer

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Publishing Dual Use Research of Concern: A Case Study

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Recently Published Articles

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