January 14, 2019

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

Duque-Correa et al.

Image credit: Duque-Correa MA, et al. (2019)

PLOS Pathogens Invites Antifungal Immunity Research

New Speaking of Medicine Blog Post

Call for Papers

01/17/2019

Review

Roles, function and relevance of LAG3 in HIV infection

Graydon et al.'s review focuses on an immune checkpoint called LAG3. LAG3 can be present on many different immune cells with differing frequency but is more abundant during HIV, in which having more LAG3 is associated with certain aspects of worse disease. If combined with other drugs and strategies to fight HIV, checkpoint blockade may allow the immune system to control HIV without the help of antiviral drugs—a functional cure.

Image credit: Graydon CG, Balasko AL, Fowke KR (2019)

Roles, function and relevance of LAG3 in HIV infection

Recently Published Articles

See all articles

Current Issue December 2018

01/17/2019

Research Article

Fibrillar structures induced by a plant reovirus target mitochondria to activate typical apoptotic response and promote viral infection in insect vectors

Chen et al.'s report that the replication of a plant reovirus, rice gall dwarf virus (RGDV), activated the apoptotic response in limited areas of leafhopper vectors during viral replication. This work presents a novel discovery that a plant reovirus induces typical apoptotic response and thus promotes its transmission by insect vectors.

Image credit: Chen Q, et al. (2019)

Fibrillar structures induced by a plant reovirus target mitochondria to activate typical apoptotic response and promote viral infection in insect vectors

01/15/2019

Research Article

Reiterative enrichment and authentication of CRISPRi targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency

Zhou et al. conduct a CRISPRi-based screen to enrich the sgRNAs that increase HIV transcription in latently infected CD4+ T cells. Their results indicate that the proteasome-ELL2 axis is a key regulator of HIV-1 latency could potentially be targeted for therapeutic interventions.

Image credit: Li Z, et al. (2019)

Reiterative enrichment and authentication of CRISPRi targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency

01/14/2019

Research Article

Antagonistic paralogs control a switch between growth and pathogen resistance in C. elegans

Reddy et al. describe a pair of species-specific genes called pals-22/pals-25 that promote resistance against natural pathogens of the small roundworm C. elegans. This gene pair acts as an on/off switch for genes that are activated after infection and rewires the physiology of worms to either be in an immune state or a growth state.

Image credit: Reddy KC, et al. (2019)

01/14/2019

Research Article

Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes

Suddala et al.'s esults imply that accumulation of IFITM3 in virus-carrying endosomes is a prerequisite for blocking fusion of diverse enveloped viruses and that viruses insensitive to this protein escape restriction by entering through distinct endosomal trafficking pathways.

Image credit: Suddala KC, et al. (2019)

01/10/2019

Featured Research

Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection

Balasubramanian et al. show that sufficient E. coli produced Shiga toxin was produced to cause lethal mouse disease, even without viral replication, potentially directing intervention strategies.

Image credit: Balasubramanian S, et al. (2019)

01/10/2019

Research Article

Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity

Pegan et al.

Image credit: Dzimianski JV, et al. (2019)

01/10/2019

Pearls

Good to the last drop: The emergence of coffee ringspot virus

Goodin and Dos Reis Figueira

Image credit: Goodin M, Dos Reis Figueira A (2019)

01/10/2019

Research Matters

Unexpected lessons from the neglected: how defective viral genomes became important again

Carolina B. López

Image credit: López CB (2019)

01/09/2019

Research Article

Recruitment of Vps34 PI3K and enrichment of PI3P phosphoinositide in the viral replication compartment is crucial for replication of a positive-strand RNA virus

Feng et al

Image credit: Feng Z, et al. (2019)

More PLOS Pathogens Research

PLOS Pathogens Microbiome Research: A Call for Papers

Publish with PLOS

Tweets by @plospathogens

Speaking of Medicine

See All Blogs

Thank you! You have successfully subscribed to the PLOS Pathogens newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

Try again

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

PLOS Pathogens Invites Antifungal Immunity Research

New Speaking of Medicine Blog Post

Roles, function and relevance of LAG3 in HIV infection

Recently Published Articles

Fibrillar structures induced by a plant reovirus target mitochondria to activate typical apoptotic response and promote viral infection in insect vectors

Reiterative enrichment and authentication of CRISPRi targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency

Antagonistic paralogs control a switch between growth and pathogen resistance in C. elegans

Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes

Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection

Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity

Good to the last drop: The emergence of coffee ringspot virus

Unexpected lessons from the neglected: how defective viral genomes became important again

Recruitment of Vps34 PI3K and enrichment of PI3P phosphoinositide in the viral replication compartment is crucial for replication of a positive-strand RNA virus

Prion acute synaptotoxicity is largely driven by protease-resistant PrP^Sc species

Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β

Identification of virus-encoded microRNAs in divergent Papillomaviruses

Inhibition of murine herpesvirus-68 replication by IFN-gamma in macrophages is counteracted by the induction of SOCS1 expression

A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors

Comparison of the human gastric microbiota in hypochlorhydric states

CagA induced dysbiosis promotes epithelial cell proliferation in the Drosophila gut

The microbiome and the hallmarks of cancer

Publish with PLOS

Get new content from PLOS Pathogens in your inbox

Thank you! You have successfully subscribed to the PLOS Pathogens newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

PLOS Pathogens Invites Antifungal Immunity Research

New Speaking of Medicine Blog Post

Recently Published Articles

Publish with PLOS

Connect with Us

Get new content from PLOS Pathogens in your inbox

Thank you! You have successfully subscribed to the PLOS Pathogens newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.