Circuit diversification in a biofilm regulatory network

Cao et al. express the ectodomains of HCV E1E2 heterodimer with either an Fc-tag or a de novo designed heterodimeric tag and are able to isolate soluble E1E2 heterodimer suitable for functional and structural studies.

Basukala et al. demonstrate that the E7 CKII site plays a direct role in maintaining a fully transformed phenotype, and indicates a novel function for this region of E7 in regulating AKT and the levels of secreted MMPs.

Law et al. show that SG localization is (i) correlated with ZAP’s antiviral function, (ii) most likely triggered during the early stages of virus replication, and (iii) a highly dynamic and transient process. Collectively, their data highlight the genetic and dynamic components of ZAP-mediated antiviral activity.