March 6, 2020
Image credit: Flickr NIAID
03/05/2020
Pearls
Preclinical noninvasive imaging techniques are increasingly used in research because they have the potential to deliver dynamic information on individual animals on a relevant time scale. Van Dyke and Rogiers and colleagues highlight the potential of using advanced noninvasive imaging techniques to address biological questions within the field of pathogenic fungi.
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Current Issue March 2020
03/12/2020
Research Article
Fusarium graminearum is a species of filamentous fungi that causes devastating disease in major staple crops. Phenamacril is a recently identified myosin I inhibitor that is a potent and highly species-specific and myosin subtype-selective fungicide. Zhou et al report the high-resolution structure of the phenamacril-bound myosin I motor domain of this major crop pathogen, providing insight into the molecular mechanism of phenamacril action and resistance.
Image credit: ppat.1008323
03/12/2020
Research Article
This study by Webb et al supports N-803 as a potent immunotherapeutic candidate and suggests that in order to fully unlock its immunotherapeutic potential it must be paired with latency reversal agents.
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03/09/2020
Research Article
The intracellular bacterium Burkholderia thailandensis invades the cytosol, hijacks host actin, and induces cell fusion to spread to adjacent cells, forming multinucleated giant cells which promote bacterial replication. Place and colleagues reveal that IFN and GBPs play a critical role in restricting cell-cell fusion and bacteria-induced pathology during infection.
Image credit: ppat.1008364
03/11/2020
Research Article
Santos-Miranda and Joviano-Santos et al show that lack of NOX2-derived ROS promoted a pro-arrhythmic phenotype, in which ROS and NO could play a role in regulating cardiomyocyte electro-mechanical function during acute CD.
Image credit: ppat.1008379
03/09/2020
Research Article
This study by Shang, Wan and Liu et al provides insight into the molecular mechanism of mouse hepatitis coronavirus (MHV) entry, demonstrating how cell entry of MHV has been adapted to its unique way of receptor binding.
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03/09/2020
Research Article
Data by Carey et al support a model in which PKCδ mediated capsid phosphorylation regulates viral RNA binding and assembly.
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03/09/2020
Research Article
Belot et al determined the crystal structure of MOKV G in its post-fusion conformation and identified several acidic residues and two histidines that play the role of pH-sensitive molecular switches during the structural transition.
Image credit: ppat.1008383
03/09/2020
Research Article
Shields and colleagues develop a CRISPR interference gene-silencing system to study essential genes encoded by Streptococcus mutans.
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03/12/2020
Research Article
Gorini and Fourati et al tested whether this vaccine modality could also reduce the risk of intravaginal SIVmac251 exposure.
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Harris and colleagues.
A PLOS Pathogens Opinion article by Dheilly and colleagues.
Cheng, Chen, Huang, and colleagues
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