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PLOS Research News

09/12/2018

featured research

Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria

The bacterium Clostridium difficile, which is responsible for the majority of antibiotic-associated diarrhea outbreaks worldwide, produces a unique compound called p-cresol to gain a competitive advantage over natural protective gut bacteria. The findings were reported by Dawson and colleagues in this PLOS Pathogens Featured Research article. 

Image credit: Passmore IJ, et al. (2018)

Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria

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Current Issue August 2018

09/13/2018

featured research

Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

New insights into how Kaposi's sarcoma-associated herpesvirus (KSHV) induces genome instability and promotes cell proliferation could lead to the development of novel antiviral therapies for KSHV-associated cancers. In this PLOS Pathogens Featured Research article, Robertson and colleagues reveal a novel mechanism by which a KSHV protein called LANA drives chromosomal instability.

Image credit: Lang F, et al. (2018)

Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

09/13/2018

featured research

CD4+T cells mediate protection against Zika associated severe disease in a mouse model of infection

A type of immune cell that produces a protein called CD4 plays an important role in protecting mice infected with the Zika virus against severe neurological disease. Based on the findings of Pinto and colleagues, vaccines that induce strong responses from these immune cells, known as CD4+T cells, should be developed to prevent invasion of the Zika virus into the brain and spinal cord. 

Image credit: NIAID, flickr

CD4+T cells mediate protection against Zika associated severe disease in a mouse model of infection

09/13/2018

pearls

It's in the mix: reassortment of segmented viral genomes

Segmentation of viral genomes allows the exchange of intact genes between related viruses when they coinfect the same cell. In this PLOS Pathogens Pearls article, Anice C. Lowen describes this type of recombination called reassortment. Lowen defines coinfection as a necessary prerequisite for reassortment, and notes the emergence of novel viruses through reassortment

It's in the mix: reassortment of segmented viral genomes

Image credit: Lowen AC (2018)

09/13/2018

pearls

Outbreaks of Histoplasmosis: The Spores Set Sail

Human infection with the pathogenic fungus Histoplasma capsulatum produces diverse clinical manifestations, ranging from an influenza-like illness to a cavitary lung disease to life-threatening dissemination. George S. Deepe, Jr. outlines the biology and natural history of H. capsulatum and the role of bird and bat droppings as well as Histoplasma outbreaks. Deepe, Jr. also addresses a spelunker’s concern that leads into the indoors and acquisition of histoplasmosis. 

Outbreaks of Histoplasmosis: The Spores Set Sail

Image credit: CDC/ Dr. Libero Ajello, Public Health Image Library

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