Three-dimensional confocal image reconstruction of a murine intestinal villus tip infected with L. monocytogenes expressing InlAm, InlB, and green fluorescent protein (GFP). Six hours after orogastric gavage, the terminal ileum was imaged with phalloidin in red to visualize actin, TO-PRO-3 in blue to see the nuclei, and GFP in green to see invading bacteria. Several replicating cytosolic bacteria surrounded by actin clouds or tails have invaded the villus tip epithelial cells. InlB accelerates invasion of the villus epithelium (see Pentecost et al., doi:10.1371/journal.ppat.1000900).
Image Credit: Mickey Pentecost and Manuel R. Amieva, Stanford University School of Medicine
Opinion
Few and Far Between: How HIV May Be Evading Antibody Avidity
PLOS Pathogens: published May 27, 2010 | https://doi.org/10.1371/journal.ppat.1000908
Pearls
The Microbiota and Allergies/Asthma
PLOS Pathogens: published May 27, 2010 | https://doi.org/10.1371/journal.ppat.1000549
Reviews
The Role of Intestinal Microbiota in the Development and Severity of Chemotherapy-Induced Mucositis
PLOS Pathogens: published May 27, 2010 | https://doi.org/10.1371/journal.ppat.1000879
The Great Escape: Viral Strategies to Counter BST-2/Tetherin
PLOS Pathogens: published May 13, 2010 | https://doi.org/10.1371/journal.ppat.1000913
Research Articles
Perforin Expression Directly Ex Vivo by HIV-Specific CD8+ T-Cells Is a Correlate of HIV Elite Control
PLOS Pathogens: published May 27, 2010 | https://doi.org/10.1371/journal.ppat.1000917
Global Migration Dynamics Underlie Evolution and Persistence of Human Influenza A (H3N2)
PLOS Pathogens: published May 27, 2010 | https://doi.org/10.1371/journal.ppat.1000918
The Haemophilus influenzae HMW1C Protein Is a Glycosyltransferase That Transfers Hexose Residues to Asparagine Sites in the HMW1 Adhesin
PLOS Pathogens: published May 27, 2010 | https://doi.org/10.1371/journal.ppat.1000919
A Complex Small RNA Repertoire Is Generated by a Plant/Fungal-Like Machinery and Effected by a Metazoan-Like Argonaute in the Single-Cell Human Parasite Toxoplasma gondii
PLOS Pathogens: published May 27, 2010 | https://doi.org/10.1371/journal.ppat.1000920
Effective, Broad Spectrum Control of Virulent Bacterial Infections Using Cationic DNA Liposome Complexes Combined with Bacterial Antigens
PLOS Pathogens: published May 27, 2010 | https://doi.org/10.1371/journal.ppat.1000921
The Early Stage of Bacterial Genome-Reductive Evolution in the Host
PLOS Pathogens: published May 27, 2010 | https://doi.org/10.1371/journal.ppat.1000922
Analysis of Virion Structural Components Reveals Vestiges of the Ancestral Ichnovirus Genome
PLOS Pathogens: published May 27, 2010 | https://doi.org/10.1371/journal.ppat.1000923
NK Cells and γδ T Cells Mediate Resistance to Polyomavirus–Induced Tumors
PLOS Pathogens: published May 27, 2010 | https://doi.org/10.1371/journal.ppat.1000924
Massive APOBEC3 Editing of Hepatitis B Viral DNA in Cirrhosis
PLOS Pathogens: published May 27, 2010 | https://doi.org/10.1371/journal.ppat.1000928
Effect of Neuraminidase Inhibitor–Resistant Mutations on Pathogenicity of Clade 2.2 A/Turkey/15/06 (H5N1) Influenza Virus in Ferrets
PLOS Pathogens: published May 27, 2010 | https://doi.org/10.1371/journal.ppat.1000933
Chlamydia pneumoniae Is Genetically Diverse in Animals and Appears to Have Crossed the Host Barrier to Humans on (At Least) Two Occasions
PLOS Pathogens: published May 20, 2010 | https://doi.org/10.1371/journal.ppat.1000903
Demonstration of Cross-Protective Vaccine Immunity against an Emerging Pathogenic Ebolavirus Species
PLOS Pathogens: published May 20, 2010 | https://doi.org/10.1371/journal.ppat.1000904
Environmental Factors Determining the Epidemiology and Population Genetic Structure of the Bacillus cereus Group in the Field
PLOS Pathogens: published May 20, 2010 | https://doi.org/10.1371/journal.ppat.1000905
Susceptibility to Anthrax Lethal Toxin-Induced Rat Death Is Controlled by a Single Chromosome 10 Locus That Includes rNlrp1
PLOS Pathogens: published May 20, 2010 | https://doi.org/10.1371/journal.ppat.1000906
Leishmania donovani Isolates with Antimony-Resistant but Not -Sensitive Phenotype Inhibit Sodium Antimony Gluconate-Induced Dendritic Cell Activation
PLOS Pathogens: published May 20, 2010 | https://doi.org/10.1371/journal.ppat.1000907
Combining ChIP-chip and Expression Profiling to Model the MoCRZ1 Mediated Circuit for Ca2+/Calcineurin Signaling in the Rice Blast Fungus
PLOS Pathogens: published May 20, 2010 | https://doi.org/10.1371/journal.ppat.1000909
Persistent Growth of a Human Plasma-Derived Hepatitis C Virus Genotype 1b Isolate in Cell Culture
PLOS Pathogens: published May 20, 2010 | https://doi.org/10.1371/journal.ppat.1000910
Neisseria meningitidis Opc Invasin Binds to the Sulphated Tyrosines of Activated Vitronectin to Attach to and Invade Human Brain Endothelial Cells
PLOS Pathogens: published May 20, 2010 | https://doi.org/10.1371/journal.ppat.1000911
The Plasmodium falciparum-Specific Human Memory B Cell Compartment Expands Gradually with Repeated Malaria Infections
PLOS Pathogens: published May 20, 2010 | https://doi.org/10.1371/journal.ppat.1000912
Mouse Senile Amyloid Fibrils Deposited in Skeletal Muscle Exhibit Amyloidosis-Enhancing Activity
PLOS Pathogens: published May 20, 2010 | https://doi.org/10.1371/journal.ppat.1000914
EBV Promotes Human CD8+ NKT Cell Development
PLOS Pathogens: published May 20, 2010 | https://doi.org/10.1371/journal.ppat.1000915
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