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Table of Contents

January 2020

Marburg virus VP40 protein (mVP40) forms projections from the plasma membrane of HEK293T cells and buds from the cells as virus-like particles (VLPs). Ectopic expression of the Hippo signaling pathway protein YAP1 results in co-localization of mVP40 with YAP1 in the cytoplasm, reducing the number of mVP40 projections at the plasma membrane and subsequent VLP budding. In this confocal image YFP-mVP40 is green and CFP-YAP1 is red, with co-localization appearing as yellow. Han et al.

Image Credit: G Ruthel, Z Han, and the Penn Vet Imaging Core at the School of Veterinary Medicine, University of Pennsylvania. (2020)

Pearls

B vitamin acquisition by gut commensal bacteria

Emily E. Putnam, Andrew L. Goodman

Hydropic anthelmintics against parasitic nematodes

Satish Kumar Rajasekharan, Jintae Lee

Gastrointestinal organoid technology advances studies of enteric virus biology

Abimbola O. Kolawole, Christiane E. Wobus

Reviews

The CRISPR toolbox in medical mycology: State of the art and perspectives

Florent Morio, Lisa Lombardi, Geraldine Butler

Immune recognition of putative alien microbial structures: Host–pathogen interactions in the age of space travel

Mihai G. Netea, Jorge Domínguez-Andrés, Marc Eleveld, Huub J. M. op den Camp, Jos W. M. van der Meer, Neil A. R. Gow, Marien I. de Jonge

Research Matters

Passing the Torch

Grant McFadden

Research Articles

USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity

Jin Liu, Lincong Jin, Xiangjie Chen, Yukang Yuan, Yibo Zuo, Ying Miao, Qian Feng, Hongguang Zhang, Fan Huang, Tingting Guo, Liting Zhang, Li Zhu, Feng Qian, Chuanwu Zhu, Hui Zheng

Novel EBV LMP-2-affibody and affitoxin in molecular imaging and targeted therapy of nasopharyngeal carcinoma

Shanli Zhu, Jun Chen, Yirong Xiong, Saidu Kamara, Meiping Gu, Wanlin Tang, Shao Chen, Haiyan Dong, Xiangyang Xue, Zhi-Ming Zheng, Lifang Zhang

Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation

Michèle Brocard, Valentina Iadevaia, Philipp Klein, Belinda Hall, Glenys Lewis, Jia Lu, James Burke, Margaret M. Willcocks, Roy Parker, Ian G. Goodfellow, Alessia Ruggieri, Nicolas Locker

Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40: Implications for filovirus biology and budding

Ziying Han, Shantoshini Dash, Cari A. Sagum, Gordon Ruthel, Chaitanya K. Jaladanki, Corbett T. Berry, Michael P. Schwoerer, Nina M. Harty, Bruce D. Freedman, Mark T. Bedford, Hao Fan, Sachdev S. Sidhu, Marius Sudol, Olena Shtanko, Ronald N. Harty

Pervasive within-host recombination and epistasis as major determinants of the molecular evolution of the foot-and-mouth disease virus capsid

Luca Ferretti, Eva Pérez-Martín, Fuquan Zhang, François Maree, Lin-Mari de Klerk-Lorist, Louis van Schalkwykc, Nicholas D. Juleff, Bryan Charleston, Paolo Ribeca

The C. elegans CHP1 homolog, pbo-1, functions in innate immunity by regulating the pH of the intestinal lumen

Saida Benomar, Patrick Lansdon, Aaron M. Bender, Blake R. Peterson, Josephine R. Chandler, Brian D. Ackley

A shear stress micromodel of urinary tract infection by the Escherichia coli producing Dr adhesin

Beata Zalewska-Piątek, Marcin Olszewski, Tomasz Lipniacki, Sławomir Błoński, Miłosz Wieczór, Piotr Bruździak, Anna Skwarska, Bogdan Nowicki, Stella Nowicki, Rafał Piątek

Epigenetic factor siRNA screen during primary KSHV infection identifies novel host restriction factors for the lytic cycle of KSHV

Nenavath Gopal Naik, Thomas Hong Nguyen, Lauren Roberts, Luke Todd Fischer, Katherine Glickman, Gavin Golas, Bernadett Papp, Zsolt Toth

Broad dengue neutralization in mosquitoes expressing an engineered antibody

Anna Buchman, Stephanie Gamez, Ming Li, Igor Antoshechkin, Hsing-Han Li, Hsin-Wei Wang, Chun-Hong Chen, Melissa J. Klein, Jean-Bernard Duchemin, James E. Crowe Jr., Prasad N. Paradkar, Omar S. Akbari

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