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Table of Contents

January 2019

At 6 days post-first access to diseased plants, leafhopper intestines are stained with TUNEL (green), virus-rhodamine (red) and actin dye phalloidin-Alexa Fluor 647 carboxylic acid (blue), and then examined by confocal microscopy. TUNEL-positive signs could be detected in the limited areas of virus-infected intestines which are stained with actin dye in about 70% of viruliferous insects. Image is representative of three independent experiments with a total 30 leafhoppers analyzed. Wei et al.

Image Credit: Qian Chen and Taiyun Wei, Fujian Agriculture and Forestry University.

Review

Roles, function and relevance of LAG3 in HIV infection

Colin G. Graydon, Allison L. Balasko, Keith R. Fowke

Research Articles

IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody

Shinji Saito, Kaori Sano, Tadaki Suzuki, Akira Ainai, Yuki Taga, Tomonori Ueno, Koshiro Tabata, Kumpei Saito, Yuji Wada, Yuki Ohara, Haruko Takeyama, Takato Odagiri, Tsutomu Kageyama, Kiyoko Ogawa-Goto, Pretty Multihartina, Vivi Setiawaty, Krisna Nur Andriana Pangesti, Hideki Hasegawa

Thymic expression of IL-4 and IL-15 after systemic inflammatory or infectious Th1 disease processes induce the acquisition of "innate" characteristics during CD8+ T cell development

Natalia S. Baez, Fabio Cerbán, Constanza Savid-Frontera, Deborah L. Hodge, Jimena Tosello, Eva Acosta-Rodriguez, Laura Almada, Adriana Gruppi, Maria Estefania Viano, Howard A. Young, Maria Cecilia Rodriguez-Galan

GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice

Berta Puig, Hermann C. Altmeppen, Luise Linsenmeier, Karima Chakroun, Florian Wegwitz, Ulrike K. Piontek, Jörg Tatzelt, Clive Bate, Tim Magnus, Markus Glatzel

Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection

Chunyi Zhou, Fatema Bhinderwala, McKenzie K. Lehman, Vinai C. Thomas, Sujata S. Chaudhari, Kelsey J. Yamada, Kirk W. Foster, Robert Powers, Tammy Kielian, Paul D. Fey

EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferation

Shengwei Zhang, Yonggang Pei, Fengchao Lang, Kunfeng Sun, Rajnish Kumar Singh, Zachary L. Lamplugh, Abhik Saha, Erle S. Robertson

Epstein-Barr virus microRNAs regulate B cell receptor signal transduction and lytic reactivation

Yan Chen, Devin Fachko, Nikita S. Ivanov, Camille M. Skinner, Rebecca L. Skalsky

Human polyomavirus BKV infection of endothelial cells results in interferon pathway induction and persistence

Ping An, Maria Teresa Sáenz Robles, Alexis M. Duray, Paul G. Cantalupo, James M. Pipas

Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity

John V. Dzimianski, Brianna S. Beldon, Courtney M. Daczkowski, Octavia Y. Goodwin, Florine E. M. Scholte, Éric Bergeron, Scott D. Pegan

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

María A. Duque-Correa, Natasha A. Karp, Catherine McCarthy, Simon Forman, David Goulding, Geetha Sankaranarayanan, Timothy P. Jenkins, Adam J. Reid, Emma L. Cambridge, Carmen Ballesteros Reviriego, The Sanger Mouse Genetics Project, The 3i consortium, Werner Müller, Cinzia Cantacessi, Gordon Dougan, Richard K. Grencis, Matthew Berriman

Antagonistic paralogs control a switch between growth and pathogen resistance in C. elegans

Kirthi C. Reddy, Tal Dror, Ryan S. Underwood, Guled A. Osman, Corrina R. Elder, Christopher A. Desjardins, Christina A. Cuomo, Michalis Barkoulas, Emily R. Troemel

Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes

Krishna C. Suddala, Christine C. Lee, Paul Meraner, Mariana Marin, Ruben M. Markosyan, Tanay M. Desai, Fredric S. Cohen, Abraham L. Brass, Gregory B. Melikyan

Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency

Zichong Li, Jun Wu, Leonard Chavez, Rebecca Hoh, Steven G. Deeks, Satish K. Pillai, Qiang Zhou

Fibrillar structures induced by a plant reovirus target mitochondria to activate typical apoptotic response and promote viral infection in insect vectors

Qian Chen, Limin Zheng, Qianzhuo Mao, Jiejie Liu, Haitao Wang, Dongsheng Jia, Hongyan Chen, Wei Wu, Taiyun Wei

Zika virus infection at mid-gestation results in fetal cerebral cortical injury and fetal death in the olive baboon

Sunam Gurung, Nicole Reuter, Alisha Preno, Jamie Dubaut, Hugh Nadeau, Kimberly Hyatt, Krista Singleton, Ashley Martin, W. Tony Parks, James F. Papin, Dean A. Myers

Tomato yellow leaf curl virus intergenic siRNAs target a host long noncoding RNA to modulate disease symptoms

Yuwen Yang, Tingli Liu, Danyu Shen, Jinyan Wang, Xitie Ling, Zhongze Hu, Tianzi Chen, Jieli Hu, Junyu Huang, Wengui Yu, Daolong Dou, Ming-Bo Wang, Baolong Zhang

Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM

Tommaso Tosi, Fumiya Hoshiga, Charlotte Millership, Rahul Singh, Charles Eldrid, Delphine Patin, Dominique Mengin-Lecreulx, Konstantinos Thalassinos, Paul Freemont, Angelika Gründling

Seroprevalence, cross antigenicity and circulation sphere of bat-borne hantaviruses revealed by serological and antigenic analyses

Lin Xu, Jianmin Wu, Qi Li, Yamei Wei, Zhizhou Tan, Jianqiu Cai, Huancheng Guo, Ling’en Yang, Xiaohong Huang, Jing Chen, Fuqiang Zhang, Biao He, Changchun Tu

Role of SpaO in the assembly of the sorting platform of a Salmonella type III secretion system

Maria Lara-Tejero, Zhuan Qin, Bo Hu, Carmen Butan, Jun Liu, Jorge E. Galán

Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium

Harald Oey, Martha Zakrzewski, Kerstin Gravermann, Neil D. Young, Pasi K. Korhonen, Geoffrey N. Gobert, Sujeevi Nawaratna, Shihab Hasan, David M. Martínez, Hong You, Martin Lavin, Malcolm K. Jones, Mark A. Ragan, Jens Stoye, Ana Oleaga, Aidan M. Emery, Bonnie L. Webster, David Rollinson, Robin B. Gasser, Donald P. McManus, Lutz Krause

Comprehensive profiling of translation initiation in influenza virus infected cells

Heather M. Machkovech, Jesse D. Bloom, Arvind R. Subramaniam

CD4+ T cells promote humoral immunity and viral control during Zika virus infection

Annie Elong Ngono, Matthew P. Young, Maximilian Bunz, Zhigang Xu, Sararat Hattakam, Edward Vizcarra, Jose Angel Regla-Nava, William W. Tang, Montarop Yamabhai, Jinsheng Wen, Sujan Shresta

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