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Table of Contents

March 2017

The image shows a cell secreting exosomes next to a cell under normal conditions. Exosomes secreted by stressed parasites as a result of inhibiting trans-splicing or under heat shock are acting as a repellent that drives the fit parasites away from either damaged cells or an unfavorable environment. This mechanism could secure a productive infection. Shulamit Michaeli et al.

Image Credit: Dror Eliaz

Pearls

Immune correlates of HIV-associated cryptococcal meningitis

Mark W. Tenforde, James E. Scriven, Thomas S. Harrison, Joseph N. Jarvis

How to develop viruses into anticancer weapons

Roberto Cattaneo, Stephen J. Russell

RNA modifications go viral

Nandan S. Gokhale, Stacy M. Horner

The human immune response to Toxoplasma: Autophagy versus cell death

Shruthi Krishnamurthy, Eleni K. Konstantinou, Lucy H. Young, Daniel A. Gold, Jeroen P. J. Saeij

Specialising the parasite nucleus: Pores, lamins, chromatin, and diversity

Michael P. Rout, Samson O. Obado, Sergio Schenkman, Mark C. Field

Review

Nod2: The intestinal gate keeper

Ziad Al Nabhani, Gilles Dietrich, Jean-Pierre Hugot, Frederick Barreau

Research Articles

Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity

Laura Jeacock, Nicola Baker, Natalie Wiedemar, Pascal Mäser, David Horn

PrPSc formation and clearance as determinants of prion tropism

Ronald A. Shikiya, Katie A. Langenfeld, Thomas E. Eckland, Jonathan Trinh, Sara A. M. Holec, Candace K. Mathiason, Anthony E. Kincaid, Jason C. Bartz

The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells

Michael Poppe, Sascha Wittig, Liane Jurida, Marek Bartkuhn, Jochen Wilhelm, Helmut Müller, Knut Beuerlein, Nadja Karl, Sabin Bhuju, John Ziebuhr, M. Lienhard Schmitz, Michael Kracht

Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA

Orr Ashenberg, Jai Padmakumar, Michael B. Doud, Jesse D. Bloom

Virus-mediated suppression of host non-self recognition facilitates horizontal transmission of heterologous viruses

Songsong Wu, Jiasen Cheng, Yanping Fu, Tao Chen, Daohong Jiang, Said A. Ghabrial, Jiatao Xie

Macrophage origin limits functional plasticity in helminth-bacterial co-infection

Dominik Rückerl, Sharon M. Campbell, Sheelagh Duncan, Tara E. Sutherland, Stephen J. Jenkins, James P. Hewitson, Tom A. Barr, Lucy H. Jackson-Jones, Rick M. Maizels, Judith E. Allen

The blood DNA virome in 8,000 humans

Ahmed Moustafa, Chao Xie, Ewen Kirkness, William Biggs, Emily Wong, Yaron Turpaz, Kenneth Bloom, Eric Delwart, Karen E. Nelson, J. Craig Venter, Amalio Telenti

Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir

John K. Bui, Michele D. Sobolewski, Brandon F. Keele, Jonathan Spindler, Andrew Musick, Ann Wiegand, Brian T. Luke, Wei Shao, Stephen H. Hughes, John M. Coffin, Mary F. Kearney, John W. Mellors

Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action

Judith Raschig, Daniela Mailänder-Sánchez, Anne Berscheid, Jürgen Berger, Adam A. Strömstedt, Lioba F. Courth, Nisar P. Malek, Heike Brötz-Oesterhelt, Jan Wehkamp

The redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains

Hong Li, Tiandi Yang, Tingting Liao, Aleksandra W. Debowski, Hans-Olof Nilsson, Alma Fulurija, Stuart M. Haslam, Barbara Mulloy, Anne Dell, Keith A. Stubbs, Barry J. Marshall, Mohammed Benghezal

Synergy between the classical and alternative pathways of complement is essential for conferring effective protection against the pandemic influenza A(H1N1) 2009 virus infection

Ajitanuj Rattan, Shailesh D. Pawar, Renuka Nawadkar, Neeraja Kulkarni, Girdhari Lal, Jayati Mullick, Arvind Sahu

Complete mapping of viral escape from neutralizing antibodies

Michael B. Doud, Scott E. Hensley, Jesse D. Bloom

Type VI secretion system contributes to Enterohemorrhagic Escherichia coli virulence by secreting catalase against host reactive oxygen species (ROS)

Baoshan Wan, Qiufen Zhang, Jinjing Ni, Shuxian Li, Donghua Wen, Jun Li, Haihan Xiao, Ping He, Hong-yu Ou, Jing Tao, Qihui Teng, Jie Lu, Wenjuan Wu, Yu-Feng Yao

H1N1 influenza viruses varying widely in hemagglutinin stability transmit efficiently from swine to swine and to ferrets

Marion Russier, Guohua Yang, Atanaska Marinova-Petkova, Peter Vogel, Bryan S. Kaplan, Richard J. Webby, Charles J. Russell

Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species

Smanla Tundup, Matheswaran Kandasamy, Jasmine T. Perez, Nacho Mena, John Steel, Tamas Nagy, Randy A. Albrecht, Balaji Manicassamy

A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses

Shashank Tripathi, Vinod R. M. T. Balasubramaniam, Julia A. Brown, Ignacio Mena, Alesha Grant, Susana V. Bardina, Kevin Maringer, Megan C. Schwarz, Ana M. Maestre, Marion Sourisseau, Randy A. Albrecht, Florian Krammer, Matthew J. Evans, Ana Fernandez-Sesma, Jean K. Lim, Adolfo García-Sastre

Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine

Rafael Prados-Rosales, Leandro Carreño, Tingting Cheng, Caroline Blanc, Brian Weinrick, Adel Malek, Todd L. Lowary, Andres Baena, Maju Joe, Yu Bai, Rainer Kalscheuer, Ana Batista-Gonzalez, Noemi A. Saavedra, Leticia Sampedro, Julen Tomás, Juan Anguita, Shang-Cheng Hung, Ashish Tripathi, Jiayong Xu, Aharona Glatman-Freedman, Williams R. Jacobs Jr., John Chan, Steven A. Porcelli, Jacqueline M. Achkar, Arturo Casadevall

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues

Alec J. Hirsch, Jessica L. Smith, Nicole N. Haese, Rebecca M. Broeckel, Christopher J. Parkins, Craig Kreklywich, Victor R. DeFilippis, Michael Denton, Patricia P. Smith, William B. Messer, Lois M. A. Colgin, Rebecca M. Ducore, Peta L. Grigsby, Jon D. Hennebold, Tonya Swanson, Alfred W. Legasse, Michael K. Axthelm, Rhonda MacAllister, Clayton A. Wiley, Jay A. Nelson, Daniel N. Streblow

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A self-perpetuating repressive state of a viral replication protein blocks superinfection by the same virus

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Exosome secretion affects social motility in Trypanosoma brucei

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Autophagy regulates UBC9 levels during viral-mediated tumorigenesis

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