Table of Contents

April 2008

Fluorescence micrograph of an NIH3T3 cell expressing the phosphatidylinositol-4,5-bisphosphate reporter PLCδ-PH-GFP (green) after infection with Salmonella typhimurium engineered to deliver augmented levels of SipC (see Cain et al., e1000037). Cells are co-stained with Texas Red-conjugated phalloidin (red) and DAPI (blue) to visualize F-actin and cell nuclei and bacteria, respectively.

Image Credit: Image generated by Robert Cain.


Pathogen Discovery

W. Ian Lipkin

Research Articles

A Novel Secretion Pathway of Salmonella enterica Acts as an Antivirulence Modulator during Salmonellosis

Ohad Gal-Mor, Deanna L. Gibson, Dan Baluta, Bruce A. Vallance, B. Brett Finlay

Deciphering Interplay between Salmonella Invasion Effectors

Robert J. Cain, Richard D. Hayward, Vassilis Koronakis

Tobacco mosaic virus Movement Protein Enhances the Spread of RNA Silencing

Hannes Vogler, Myoung-Ok Kwon, Vy Dang, Adrian Sambade, Monika Fasler, Jamie Ashby, Manfred Heinlein

The MHV68 M2 Protein Drives IL-10 Dependent B Cell Proliferation and Differentiation

Andrea M. Siegel, Jeremy H. Herskowitz, Samuel H. Speck

Stimulation of Chitin Synthesis Rescues Candida albicans from Echinocandins

Louise A. Walker, Carol A. Munro, Irene de Bruijn, Megan D. Lenardon, Alastair McKinnon, Neil A. R. Gow

Tentative T Cells: Memory Cells Are Quick to Respond, but Slow to Divide

Jason K. Whitmire, Boreth Eam, J. Lindsay Whitton

An Unbiased Systems Genetics Approach to Mapping Genetic Loci Modulating Susceptibility to Severe Streptococcal Sepsis

Nourtan F. Abdeltawab, Ramy K. Aziz, Rita Kansal, Sarah L. Rowe, Yin Su, Lidia Gardner, Charity Brannen, Mohammed M. Nooh, Ramy R. Attia, Hossam A. Abdelsamed, William L. Taylor, Lu Lu, Robert W. Williams, Malak Kotb

Human-Like Receptor Specificity Does Not Affect the Neuraminidase-Inhibitor Susceptibility of H5N1 Influenza Viruses

Natalia A. Ilyushina, Elena A. Govorkova, Thomas E. Gray, Nicolai V. Bovin, Robert G. Webster

Histoplasma Requires SID1, a Member of an Iron-Regulated Siderophore Gene Cluster, for Host Colonization

Lena H. Hwang, Jacob A. Mayfield, Jasper Rine, Anita Sil

Molecular and Cellular Basis of Microvascular Perfusion Deficits Induced by Clostridium perfringens and Clostridium septicum

Michael J. Hickey, Rain Y. Q. Kwan, Milena M. Awad, Catherine L. Kennedy, Lauren F. Young, Pam Hall, Leanne M. Cordner, Dena Lyras, John J. Emmins, Julian I. Rood

Chapare Virus, a Newly Discovered Arenavirus Isolated from a Fatal Hemorrhagic Fever Case in Bolivia

Simon Delgado, Bobbie R. Erickson, Roberto Agudo, Patrick J. Blair, Efrain Vallejo, César G. Albariño, Jorge Vargas, James A. Comer, Pierre E. Rollin, Thomas G. Ksiazek, James G. Olson, Stuart T. Nichol

DC-SIGN and CD150 Have Distinct Roles in Transmission of Measles Virus from Dendritic Cells to T-Lymphocytes

Lot de Witte, Rory D. de Vries, Michiel van der Vlist, Selma Yüksel, Manja Litjens, Rik L. de Swart, Teunis B. H. Geijtenbeek

Transmission Pathways of Foot-and-Mouth Disease Virus in the United Kingdom in 2007

Eleanor M. Cottam, Jemma Wadsworth, Andrew E. Shaw, Rebecca J. Rowlands, Lynnette Goatley, Sushila Maan, Narender S. Maan, Peter P. C. Mertens, Katja Ebert, Yanmin Li, Eoin D. Ryan, Nicholas Juleff, Nigel P. Ferris, John W. Wilesmith, Daniel T. Haydon, Donald P. King, David J. Paton, Nick J. Knowles

agr-Mediated Dispersal of Staphylococcus aureus Biofilms

Blaise R. Boles, Alexander R. Horswill

HDP—A Novel Heme Detoxification Protein from the Malaria Parasite

Dewal Jani, Rana Nagarkatti, Wandy Beatty, Ross Angel, Carla Slebodnick, John Andersen, Sanjai Kumar, Dharmendar Rathore