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Table of Contents

December 2018

Immunofluorescence microscopy was used to stain for bladder epithelial differentiation markers like keratin 20 (white) and Trp63 (red). We found that mice with a history of chronic bladder infection had aberrant epithelial differentiation and bladder mucosal remodeling that persisted after antibiotic treatment and increased their susceptibility to recurrent infections. O'Brien et al.

Image Credit: Valerie P. O'Brien, Denise A. Dorsey, Thomas J. Hannan, Scott J. Hultgren

Pearls

Innate antimicrobial immunity in the skin: A protective barrier against bacteria, viruses, and fungi

Margaret Coates, Sarah Blanchard, Amanda S. MacLeod

Is sex necessary for the proliferation and transmission of Pneumocystis?

Philippe M. Hauser, Melanie T. Cushion

Candida–streptococcal interactions in biofilm-associated oral diseases

Hyun Koo, David R. Andes, Damian J. Krysan

Barrett’s esophagus and esophageal cancer: Links to microbes and the microbiome

Teminioluwa A. Ajayi, Sarah Cantrell, Ashley Spann, Katherine S. Garman

Toll-like receptor 4 in acute viral infection: Too much of a good thing

Judith Olejnik, Adam J. Hume, Elke Mühlberger

Deacetylated microbial biofilm exopolysaccharides: It pays to be positive

Hanna Ostapska, P. Lynne Howell, Donald C. Sheppard

Research Articles

Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine

Xiaojian Zhang, Hailiang Sun, Fred L. Cunningham, Lei Li, Katie Hanson-Dorr, Matthew W. Hopken, Jim Cooley, Li-Ping Long, John A. Baroch, Tao Li, Brandon S. Schmit, Xiaoxu Lin, Alicia K. Olivier, Richard G. Jarman, Thomas J. DeLiberto, Xiu-Feng Wan

Different functional states of fusion protein gB revealed on human cytomegalovirus by cryo electron tomography with Volta phase plate

Zhu Si, Jiayan Zhang, Sakar Shivakoti, Ivo Atanasov, Chang-Lu Tao, Wong H. Hui, Kang Zhou, Xuekui Yu, Weike Li, Ming Luo, Guo-Qiang Bi, Z. Hong Zhou

The afc antifungal activity cluster, which is under tight regulatory control of ShvR, is essential for transition from intracellular persistence of Burkholderia cenocepacia to acute pro-inflammatory infection

Margarida C. Gomes, Yara Tasrini, Sujatha Subramoni, Kirsty Agnoli, Joana R. Feliciano, Leo Eberl, Pamela Sokol, David O’Callaghan, Annette C. Vergunst

Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress

Alfredo J. Guerra, Ou Zhang, Constance M. E. Bahr, My-Hang Huynh, James DelProposto, William C. Brown, Zdzislaw Wawrzak, Nicole M. Koropatkin, Vern B. Carruthers

Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge

Hugh C. Welles, Madeleine F. Jennewein, Rosemarie D. Mason, Sandeep Narpala, Lingshu Wang, Cheng Cheng, Yi Zhang, John-Paul Todd, Jeffrey D. Lifson, Alejandro B. Balazs, Galit Alter, Adrian B. McDermott, John R. Mascola, Mario Roederer

The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence

Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M. Meyer, Tim van Opijnen

Transmission dynamics of re-emerging rabies in domestic dogs of rural China

Huaiyu Tian, Yun Feng, Bram Vrancken, Bernard Cazelles, Hua Tan, Mandev S. Gill, Qiqi Yang, Yidan Li, Weihong Yang, Yuzhen Zhang, Yunzhi Zhang, Philippe Lemey, Oliver G. Pybus, Nils Chr. Stenseth, Hailin Zhang, Simon Dellicour

CCR5 structural plasticity shapes HIV-1 phenotypic properties

Philippe Colin, Zhicheng Zhou, Isabelle Staropoli, Javier Garcia-Perez, Romain Gasser, Marie Armani-Tourret, Yann Benureau, Nuria Gonzalez, Jun Jin, Bridgette J. Connell, Stéphanie Raymond, Pierre Delobel, Jacques Izopet, Hugues Lortat-Jacob, Jose Alcami, Fernando Arenzana-Seisdedos, Anne Brelot, Bernard Lagane

Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice

Dwain G. van Zyl, Ming-Han Tsai, Anatoliy Shumilov, Viktor Schneidt, Rémy Poirey, Bettina Schlehe, Herbert Fluhr, Josef Mautner, Henri-Jacques Delecluse

A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans

Julio Diaz Caballero, Shawn T. Clark, Pauline W. Wang, Sylva L. Donaldson, Bryan Coburn, D. Elizabeth Tullis, Yvonne C. W. Yau, Valerie J. Waters, David M. Hwang, David S. Guttman

Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection

Valeria Ciancarella, Luigi Lembo-Fazio, Ida Paciello, Anna-Karin Bruno, Sébastien Jaillon, Sara Berardi, Marialuisa Barbagallo, Shiri Meron-Sudai, Dani Cohen, Antonio Molinaro, Giacomo Rossi, Cecilia Garlanda, Maria Lina Bernardini

STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus

Feng Gu, Chong Wang, Fang Wei, Yuyan Wang, Qing Zhu, Ling Ding, Wenjia Xu, Caixia Zhu, Cankun Cai, Zhikang Qian, Zhenghong Yuan, Erle Robertson, Qiliang Cai

Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion

Jérôme Gouttenoire, Angela Pollán, Laurence Abrami, Noémie Oechslin, Johann Mauron, Maxime Matter, Joël Oppliger, Dagmara Szkolnicka, Viet Loan Dao Thi, F. Gisou van der Goot, Darius Moradpour

Activation of E2F-dependent transcription by the mouse cytomegalovirus M117 protein affects the viral host range

Eléonore Ostermann, Stefan Loroch, Zhikang Qian, Albert Sickmann, Lüder Wiebusch, Wolfram Brune

Genetically modified pigs are protected from classical swine fever virus

Zicong Xie, Daxin Pang, Hongming Yuan, Huping Jiao, Chao Lu, Kankan Wang, Qiangbing Yang, Mengjing Li, Xue Chen, Tingting Yu, Xinrong Chen, Zhen Dai, Yani Peng, Xiaochun Tang, Zhanjun Li, Tiedong Wang, Huancheng Guo, Li Li, Changchun Tu, Liangxue Lai, Hongsheng Ouyang

Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner

Valerie P. O’Brien, Denise A. Dorsey, Thomas J. Hannan, Scott J. Hultgren

Quantitative RNAseq analysis of Ugandan KS tumors reveals KSHV gene expression dominated by transcription from the LTd downstream latency promoter

Timothy M. Rose, A. Gregory Bruce, Serge Barcy, Matt Fitzgibbon, Lisa R. Matsumoto, Minako Ikoma, Corey Casper, Jackson Orem, Warren Phipps

EBV-miR-BART1-5P activates AMPK/mTOR/HIF1 pathway via a PTEN independent manner to promote glycolysis and angiogenesis in nasopharyngeal carcinoma

Xiaoming Lyu, Jianguo Wang, Xia Guo, Gongfa Wu, Yang Jiao, Oluwasijibomi Damola Faleti, Pengfei Liu, Tielian Liu, Yufei Long, Tuotuo Chong, Xu Yang, Jing Huang, Mingliang He, Chi Man Tsang, Sai Wah Tsao, Qian Wang, Qiang Jiang, Xin Li

Gluconeogenesis is essential for trypanosome development in the tsetse fly vector

Marion Wargnies, Eloïse Bertiaux, Edern Cahoreau, Nicole Ziebart, Aline Crouzols, Pauline Morand, Marc Biran, Stefan Allmann, Jane Hubert, Oriana Villafraz, Yoann Millerioux, Nicolas Plazolles, Corinne Asencio, Loïc Rivière, Brice Rotureau, Michael Boshart, Jean-Charles Portais, Frédéric Bringaud

Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure

Julia Heger-Stevic, Peter Zimmermann, Lauriane Lecoq, Bettina Böttcher, Michael Nassal

Roles of GP33, a guinea pig cytomegalovirus-encoded G protein-coupled receptor homolog, in cellular signaling, viral growth and inflammation in vitro and in vivo

Miei Takeda, Shinji Watanabe, Harutaka Katano, Kazuma Noguchi, Yuko Sato, Sayaka Kojima, Takuya Miura, Ryuichi Majima, Souichi Yamada, Naoki Inoue

EspL is essential for virulence and stabilizes EspE, EspF and EspH levels in Mycobacterium tuberculosis

Claudia Sala, Nina T. Odermatt, Paloma Soler-Arnedo, Muhammet F. Gülen, Sofia von Schultz, Andrej Benjak, Stewart T. Cole

A potent Lassa virus antiviral targets an arenavirus virulence determinant

Ikenna G. Madu, Megan Files, Dima N. Gharaibeh, Amy L. Moore, Kie-Hoon Jung, Brian B. Gowen, Dongcheng Dai, Kevin F. Jones, Shanthakumar R. Tyavanagimatt, James R. Burgeson, Marcus J. Korth, Kristin M. Bedard, Shawn P. Iadonato, Sean M. Amberg

Heme sensing and detoxification by HatRT contributes to pathogenesis during Clostridium difficile infection

Reece J. Knippel, Joseph P. Zackular, Jessica L. Moore, Arianna I. Celis, Andy Weiss, M. Kay Washington, Jennifer L. DuBois, Richard M. Caprioli, Eric P. Skaar

Visualization of translocons in Yersinia type III protein secretion machines during host cell infection

Theresa Nauth, Franziska Huschka, Michaela Schweizer, Jens B. Bosse, Andreas Diepold, Antonio Virgilio Failla, Anika Steffen, Theresia E. B. Stradal, Manuel Wolters, Martin Aepfelbacher

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei

Julie Kovářová, Rupa Nagar, Joana Faria, Michael A. J. Ferguson, Michael P. Barrett, David Horn

Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection

Daiane M. Cerqueira, Marco Túlio R. Gomes, Alexandre L. N. Silva, Marcella Rungue, Natan R. G. Assis, Erika S. Guimarães, Suellen B. Morais, Petr Broz, Dario S. Zamboni, Sergio C. Oliveira

Modeling the measles paradox reveals the importance of cellular immunity in regulating viral clearance

Sinead E. Morris, Andrew J. Yates, Rik L. de Swart, Rory D. de Vries, Michael J. Mina, Ashley N. Nelson, Wen-Hsuan W. Lin, Roger D. Kouyos, Diane E. Griffin, Bryan T. Grenfell

The ESCRT and autophagy machineries cooperate to repair ESX-1-dependent damage at the Mycobacterium-containing vacuole but have opposite impact on containing the infection

Ana T. López-Jiménez, Elena Cardenal-Muñoz, Florence Leuba, Lilli Gerstenmaier, Caroline Barisch, Monica Hagedorn, Jason S. King, Thierry Soldati