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Table of Contents

February 2018

Scanning electron microscopic images of retrovirus-infected cells and regulatory T cells. Dittmer et al.

Image Credit: Kim Hasenkrug, Dave Dorward and Austin Athman, Rocky Mountain Laboratories, NIAID, NIH.

Pearls

Pneumocystis and interactions with host immune receptors

Jennifer Claire Hoving

RNA 3-dimensional structural motifs as a critical constraint of viroid RNA evolution

Ying Wang, Craig L. Zirbel, Neocles B. Leontis, Biao Ding

Tricked or trapped—Two decoy mechanisms in host–pathogen interactions

Judith K. Paulus, Renier A. L. van der Hoorn

Animal TSEs and public health: What remains of past lessons?

Saima Zafar, Mohsin Shafiq, Olivier Andréoletti, Inga Zerr

“Cyst-ained” research into Heterodera parasitism

Parijat S. Juvale, Thomas J. Baum

TRIM proteins: New players in virus-induced autophagy

Konstantin M. J. Sparrer, Michaela U. Gack

Reviews

Regulatory T cells in retroviral infections

Kim J. Hasenkrug, Claire A. Chougnet, Ulf Dittmer

Research Matters

Virologists—Heroes need weapons

Franziska Hufsky, Bashar Ibrahim, Martin Beer, Li Deng, Philippe Le Mercier, Dino P. McMahon, Massimo Palmarini, Volker Thiel, Manja Marz

Research Articles

RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription

Charles-Adrien Richard, Vincent Rincheval, Safa Lassoued, Jenna Fix, Christophe Cardone, Camille Esneau, Sergei Nekhai, Marie Galloux, Marie-Anne Rameix-Welti, Christina Sizun, Jean-François Eléouët

Human dengue virus serotype 2 neutralizing antibodies target two distinct quaternary epitopes

Emily N. Gallichotte, Thomas J. Baric, Boyd L. Yount Jr, Douglas G. Widman, Anna Durbin, Steve Whitehead, Ralph S. Baric, Aravinda M. de Silva

Genetic mechanisms of Coxiella burnetii lipopolysaccharide phase variation

Paul A. Beare, Brendan M. Jeffrey, Carrie M. Long, Craig M. Martens, Robert A. Heinzen

Timing of host feeding drives rhythms in parasite replication

Kimberley F. Prior, Daan R. van der Veen, Aidan J. O’Donnell, Katherine Cumnock, David Schneider, Arnab Pain, Amit Subudhi, Abhinay Ramaprasad, Samuel S. C. Rund, Nicholas J. Savill, Sarah E. Reece

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques

P. J. Klasse, Thomas J. Ketas, Christopher A. Cottrell, Gabriel Ozorowski, Gargi Debnath, Diawoye Camara, Erik Francomano, Pavel Pugach, Rajesh P. Ringe, Celia C. LaBranche, Marit J. van Gils, Christine A. Bricault, Dan H. Barouch, Shane Crotty, Guido Silvestri, Sudhir Kasturi, Bali Pulendran, Ian A. Wilson, David C. Montefiori, Rogier W. Sanders, Andrew B. Ward, John P. Moore

Insect tissue-specific vitellogenin facilitates transmission of plant virus

Yan Huo, Yuanling Yu, Liying Chen, Qiong Li, Mengting Zhang, Zhiyu Song, Xiaoying Chen, Rongxiang Fang, Lili Zhang

Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes

Dionysios C. Watson, Eirini Moysi, Antonio Valentin, Cristina Bergamaschi, Santhi Devasundaram, Sotirios P. Fortis, Jenifer Bear, Elena Chertova, Julian Bess Jr., Ray Sowder, David J. Venzon, Claire Deleage, Jacob D. Estes, Jeffrey D. Lifson, Constantinos Petrovas, Barbara K. Felber, George N. Pavlakis

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Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection

Sarah Auclair, Fengliang Liu, Qingli Niu, Wei Hou, Gavin Churchyard, Cecilia Morgan, Nicole Frahm, Sorachai Nitayaphan, Punnee Pitisuthithum, Supachai Rerks-Ngarm, Jason T. Kimata, Lynn Soong, Genoveffa Franchini, Merlin Robb, Jerome Kim, Nelson Michael, Haitao Hu

HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis

Kyle Burrows, Frann Antignano, Alistair Chenery, Michael Bramhall, Vladimir Korinek, T. Michael Underhill, Colby Zaph

Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30

Louise E. Hogan, Joshua Vasquez, Kristen S. Hobbs, Emily Hanhauser, Brandon Aguilar-Rodriguez, Rajaa Hussien, Cassandra Thanh, Erica A. Gibson, Alexander B. Carvidi, Louis C. B. Smith, Shahzada Khan, Martin Trapecar, Shomyseh Sanjabi, Ma Somsouk, Cheryl A. Stoddart, Daniel R. Kuritzkes, Steven G. Deeks, Timothy J. Henrich

Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins

Jarrod J. Mousa, Elad Binshtein, Stacey Human, Rachel H. Fong, Gabriela Alvarado, Benjamin J. Doranz, Martin L. Moore, Melanie D. Ohi, James E. Crowe Jr.

Two essential Thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii

Marco Biddau, Anne Bouchut, Jack Major, Tracy Saveria, Julie Tottey, Ojore Oka, Marcel van-Lith, Katherine Elizabeth Jennings, Jana Ovciarikova, Amy DeRocher, Boris Striepen, Ross Frederick Waller, Marilyn Parsons, Lilach Sheiner

Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART

Bridget S. Fisher, Richard R. Green, Rachel R. Brown, Matthew P. Wood, Tiffany Hensley-McBain, Cole Fisher, Jean Chang, Andrew D. Miller, William J. Bosche, Jeffrey D. Lifson, Maud Mavigner, Charlene J. Miller, Michael Gale Jr., Guido Silvestri, Ann Chahroudi, Nichole R. Klatt, Donald L. Sodora

Quantifying the fitness cost of HIV-1 drug resistance mutations through phylodynamics

Denise Kühnert, Roger Kouyos, George Shirreff, Jūlija Pečerska, Alexandra U. Scherrer, Jürg Böni, Sabine Yerly, Thomas Klimkait, Vincent Aubert, Huldrych F. Günthard, Tanja Stadler, Sebastian Bonhoeffer, the Swiss HIV Cohort Study

DHX29 functions as an RNA co-sensor for MDA5-mediated EMCV-specific antiviral immunity

Qingyuan Zhu, Peng Tan, Yinyin Li, Meng Lin, Chaoran Li, Jingrong Mao, Jun Cui, Wei Zhao, Helen Y. Wang, Rong-Fu Wang

The novel antibiotic rhodomyrtone traps membrane proteins in vesicles with increased fluidity

Dennapa Saeloh, Varomyalin Tipmanee, Kin Ki Jim, Marien P. Dekker, Wilbert Bitter, Supayang P. Voravuthikunchai, Michaela Wenzel, Leendert W. Hamoen

Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication

Kevin Tsai, David G. Courtney, Bryan R. Cullen

Murine cytomegalovirus degrades MHC class II to colonize the salivary glands

Joseph Yunis, Helen E. Farrell, Kimberley Bruce, Clara Lawler, Stine Sidenius, Orry Wyer, Nicholas Davis-Poynter, Philip G. Stevenson

A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection

Xiangzhi Meng, Fushun Zhang, Bo Yan, Chuanping Si, Hiroaki Honda, Akiko Nagamachi, Lu-Zhe Sun, Yan Xiang

Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission

Yogy Simanjuntak, Jian-Jong Liang, Si-Yu Chen, Jin-Kun Li, Yi-Ling Lee, Han-Chung Wu, Yi-Ling Lin

Dynamic remodeling of lipids coincides with dengue virus replication in the midgut of Aedes aegypti mosquitoes

Nunya Chotiwan, Barbara G. Andre, Irma Sanchez-Vargas, M. Nurul Islam, Jeffrey M. Grabowski, Amber Hopf-Jannasch, Erik Gough, Ernesto Nakayasu, Carol D. Blair, John T. Belisle, Catherine A. Hill, Richard J. Kuhn, Rushika Perera

Cross-priming induces immunodomination in the presence of viral MHC class I inhibition

Elvin J. Lauron, Liping Yang, Jabari I. Elliott, Maria D. Gainey, Daved H. Fremont, Wayne M. Yokoyama

A conserved Eph family receptor-binding motif on the gH/gL complex of Kaposi’s sarcoma-associated herpesvirus and rhesus monkey rhadinovirus

Anna K. Großkopf, Armin Ensser, Frank Neipel, Doris Jungnickl, Sarah Schlagowski, Ronald C. Desrosiers, Alexander S. Hahn

GM1 ganglioside-independent intoxication by Cholera toxin

Jakob Cervin, Amberlyn M. Wands, Anna Casselbrant, Han Wu, Soumya Krishnamurthy, Aleksander Cvjetkovic, Johanna Estelius, Benjamin Dedic, Anirudh Sethi, Kerri-Lee Wallom, Rebecca Riise, Malin Bäckström, Ville Wallenius, Frances M. Platt, Michael Lebens, Susann Teneberg, Lars Fändriks, Jennifer J. Kohler, Ulf Yrlid

Structural basis of mammalian glycan targeting by Vibrio cholerae cytolysin and biofilm proteins

Swastik De, Katherine Kaus, Shada Sinclair, Brandon C. Case, Rich Olson

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase

Paul C. Jordan, Cheng Liu, Pauline Raynaud, Michael K. Lo, Christina F. Spiropoulou, Julian A. Symons, Leo Beigelman, Jerome Deval

Schistosoma mansoni SmKI-1 serine protease inhibitor binds to elastase and impairs neutrophil function and inflammation

Suellen B. Morais, Barbara C. Figueiredo, Natan R. G. Assis, Debora M. Alvarenga, Mariana T. Q. de Magalhães, Rafaela S. Ferreira, Angélica T. Vieira, Gustavo B. Menezes, Sergio C. Oliveira

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles

Ning Zhang, Martin Zoltner, Ka-Fai Leung, Paul Scullion, Sebastian Hutchinson, Ricardo C. del Pino, Isabel M. Vincent, Yong-Kang Zhang, Yvonne R. Freund, Michael R. K. Alley, Robert T. Jacobs, Kevin D. Read, Michael P. Barrett, David Horn, Mark C. Field

When are pathogen genome sequences informative of transmission events?

Finlay Campbell, Camilla Strang, Neil Ferguson, Anne Cori, Thibaut Jombart

Picornavirus 2A protease regulates stress granule formation to facilitate viral translation

Xiaodan Yang, Zhulong Hu, Shanshan Fan, Qiang Zhang, Yi Zhong, Dong Guo, Yali Qin, Mingzhou Chen

RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases

Yi-Han Lin, María Lucas, Timothy R. Evans, Guillermo Abascal-Palacios, Alexandra G. Doms, Nicole A. Beauchene, Adriana L. Rojas, Aitor Hierro, Matthias P. Machner

NS2 proteases from hepatitis C virus and related hepaciviruses share composite active sites and previously unrecognized intrinsic proteolytic activities

Célia Boukadida, Matthieu Fritz, Brigitte Blumen, Marie-Laure Fogeron, François Penin, Annette Martin

Comparative transcriptomics reveals CrebA as a novel regulator of infection tolerance in D. melanogaster

Katia Troha, Joo Hyun Im, Jonathan Revah, Brian P. Lazzaro, Nicolas Buchon

Pseudomonas aeruginosa rugose small-colony variants evade host clearance, are hyper-inflammatory, and persist in multiple host environments

Matthew J. Pestrak, Sarah B. Chaney, Heather C. Eggleston, Sheri Dellos-Nolan, Sriteja Dixit, Shomita S. Mathew-Steiner, Sashwati Roy, Matthew R. Parsek, Chandan K. Sen, Daniel J. Wozniak

Loss of CNFY toxin-induced inflammation drives Yersinia pseudotuberculosis into persistency

Wiebke Heine, Michael Beckstette, Ann Kathrin Heroven, Sophie Thiemann, Ulrike Heise, Aaron Mischa Nuss, Fabio Pisano, Till Strowig, Petra Dersch

Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice

Nick D. Van Skike, Nana K. Minkah, Chad H. Hogan, Gary Wu, Peter T. Benziger, Darby G. Oldenburg, Mehmet Kara, Deborah M. Kim-Holzapfel, Douglas W. White, Scott A. Tibbetts, Jarrod B. French, Laurie T. Krug

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