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Table of Contents

August 2018

Confocal image of systemically infected zebrafish larva with the espH mutant at 4 days post infection. The mCherry-expressing bacteria show extensive outgrowth in or near the blood vessels (green) and in the absence of L-plastin-labelled phagocytic cells (cyan). Bitter et al.

Image Credit: Lisanne M. van Leeuwen

Pearls

The devil is in the details: Genomics of transmissible cancers in Tasmanian devils

Andrew Storfer, Paul A. Hohenlohe, Mark J. Margres, Austin Patton, Alexandra K. Fraik, Matthew Lawrance, Lauren E. Ricci, Amanda R. Stahlke, Hamish I. McCallum, Menna E. Jones

Bat pathogens hit the road: But which one?

Léa Joffrin, Muriel Dietrich, Patrick Mavingui, Camille Lebarbenchon

cGAS and STING: At the intersection of DNA and RNA virus-sensing networks

Guoxin Ni, Zhe Ma, Blossom Damania

Five pillars of centromeric chromatin in fungal pathogens

Vikas Yadav, Lakshmi Sreekumar, Krishnendu Guin, Kaustuv Sanyal

Research Articles

S‐acylation mediates Mungbean yellow mosaic virus AC4 localization to the plasma membrane and in turns gene silencing suppression

Anna Vittoria Carluccio, Maria Isabella Prigigallo, Tabata Rosas-Diaz, Rosa Lozano-Duran, Livia Stavolone

Alcohol enhances type 1 interferon-α production and mortality in young mice infected with Mycobacterium tuberculosis

Deepak Tripathi, Elwyn Welch, Satyanarayana Swamy Cheekatla, Rajesh Kumar Radhakrishnan, Sambasivan Venkatasubramanian, Padmaja Paidipally, Abhinav Van, Buka Samten, Kamakshi P. Devalraju, Venkata Sanjeev Kumar Neela, Vijaya Lakshmi Valluri, Carol Mason, Steve Nelson, Ramakrishna Vankayalapati

The Sec1/Munc18 (SM) protein Vps45 is involved in iron uptake, mitochondrial function and virulence in the pathogenic fungus Cryptococcus neoformans

Mélissa Caza, Guanggan Hu, Erik David Nielson, Minsu Cho, Won Hee Jung, James W. Kronstad

Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing

Emily E. Rosowski, Nicholas Raffa, Benjamin P. Knox, Netta Golenberg, Nancy P. Keller, Anna Huttenlocher

A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism

Eirini D. Tseligka, Komla Sobo, Luc Stoppini, Valeria Cagno, Fabien Abdul, Isabelle Piuz, Pascal Meylan, Song Huang, Samuel Constant, Caroline Tapparel

Inhibition of murine herpesvirus-68 replication by IFN-gamma in macrophages is counteracted by the induction of SOCS1 expression

Yong Shen, Saisai Wang, Fangfang Sun, Gang Zheng, Tingting Wu, Yushen Du, Suzhan Zhang, Jing Qian, Ren Sun

Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice

Wolfgang Koestner, Julia Spanier, Tanja Klause, Pia-K. Tegtmeyer, Jennifer Becker, Vanessa Herder, Katharina Borst, Daniel Todt, Stefan Lienenklaus, Ingo Gerhauser, Claudia N. Detje, Robert Geffers, Martijn A. Langereis, Florian W. R. Vondran, Qinggong Yuan, Frank J. M. van Kuppeveld, Michael Ott, Peter Staeheli, Eike Steinmann, Wolfgang Baumgärtner, Frank Wacker, Ulrich Kalinke

Reconstruction of the cell entry pathway of an extinct virus

Lindsey R. Robinson-McCarthy, Kevin R. McCarthy, Matthijs Raaben, Silvia Piccinotti, Joppe Nieuwenhuis, Sarah H. Stubbs, Mark J. G. Bakkers, Sean P. J. Whelan

Cellular N-myristoyltransferases play a crucial picornavirus genus-specific role in viral assembly, virion maturation, and infectivity

Irena Corbic Ramljak, Julia Stanger, Antonio Real-Hohn, Dominik Dreier, Laurin Wimmer, Monika Redlberger-Fritz, Wolfgang Fischl, Karin Klingel, Marko D. Mihovilovic, Dieter Blaas, Heinrich Kowalski

The Epstein Barr virus circRNAome

Nathan Ungerleider, Monica Concha, Zhen Lin, Claire Roberts, Xia Wang, Subing Cao, Melody Baddoo, Walter N. Moss, Yi Yu, Michael Seddon, Terri Lehman, Scott Tibbetts, Rolf Renne, Yan Dong, Erik K. Flemington

A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors

Valerio Leoni, Andrea Vannini, Valentina Gatta, Julie Rambaldi, Mara Sanapo, Catia Barboni, Anna Zaghini, Patrizia Nanni, Pier-Luigi Lollini, Costanza Casiraghi, Gabriella Campadelli-Fiume

Type I IFNs drive hematopoietic stem and progenitor cell collapse via impaired proliferation and increased RIPK1-dependent cell death during shock-like ehrlichial infection

Julianne N. P. Smith, Yubin Zhang, Jing Jing Li, Amanda McCabe, Hui Jin Jo, Jackson Maloney, Katherine C. MacNamara

Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β

Michelle Ainouze, Pauline Rochefort, Peggy Parroche, Guillaume Roblot, Issam Tout, François Briat, Claudia Zannetti, Marie Marotel, Nadege Goutagny, Philip Auron, Alexandra Traverse-Glehen, Aude Lunel-Potencier, Francois Golfier, Murielle Masson, Alexis Robitaille, Massimo Tommasino, Christine Carreira, Thierry Walzer, Thomas Henry, Katia Zanier, Gilles Trave, Uzma Ayesha Hasan

Clostridium difficile exosporium cysteine-rich proteins are essential for the morphogenesis of the exosporium layer, spore resistance, and affect C. difficile pathogenesis

Paulina Calderón-Romero, Pablo Castro-Córdova, Rodrigo Reyes-Ramírez, Mauro Milano-Céspedes, Enzo Guerrero-Araya, Marjorie Pizarro-Guajardo, Valeria Olguín-Araneda, Fernando Gil, Daniel Paredes-Sabja

Prion acute synaptotoxicity is largely driven by protease-resistant PrPSc species

Simote Totauhelotu Foliaki, Victoria Lewis, David Isaac Finkelstein, Victoria Lawson, Harold Arthur Coleman, Matteo Senesi, Abu Mohammed Taufiqual Islam, Feng Chen, Shannon Sarros, Blaine Roberts, Paul Anthony Adlard, Steven John Collins

The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function

Fei Yuan, Zeng-Qiang Gao, Vladimir Majerciak, Lei Bai, Meng-Lu Hu, Xiao-Xi Lin, Zhi-Ming Zheng, Yu-Hui Dong, Ke Lan

Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces

Hongbo Guo, Huib Rabouw, Anne Slomp, Meiling Dai, Floor van der Vegt, Jan W. M. van Lent, Ryan McBride, James C. Paulson, Raoul J. de Groot, Frank J. M. van Kuppeveld, Erik de Vries, Cornelis A. M. de Haan

Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice

Stephanie L. Brandt, Nathan Klopfenstein, Soujuan Wang, Seth Winfree, Brian P. McCarthy, Paul R. Territo, Lloyd Miller, C. Henrique Serezani

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF

Trang H. Phan, Lisanne M. van Leeuwen, Coen Kuijl, Roy Ummels, Gunny van Stempvoort, Alba Rubio-Canalejas, Sander R. Piersma, Connie R. Jiménez, Astrid M. van der Sar, Edith N. G. Houben, Wilbert Bitter

Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins

Thorsten Brink, Veronika Leiss, Peter Siegert, Doris Jehle, Julia K. Ebner, Carsten Schwan, Aliaksei Shymanets, Sebastian Wiese, Bernd Nürnberg, Michael Hensel, Klaus Aktories, Joachim H. C. Orth

Immobility in the sedentary plant-parasitic nematode H. glycines is associated with remodeling of neuromuscular tissue

Ziduan Han, Sita Thapa, Ursula Reuter-Carlson, Hannah Reed, Michael Gates, Kris N. Lambert, Nathan E. Schroeder

Stearoly-CoA desaturase 1 differentiates early and advanced dengue virus infections and determines virus particle infectivity

Rebekah C. Gullberg, J. Jordan Steel, Venugopal Pujari, Joel Rovnak, Dean C. Crick, Rushika Perera

Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells

Thi Thu Phuong Tran, Karsten Eichholz, Patrizia Amelio, Crystal Moyer, Glen R. Nemerow, Matthieu Perreau, Franck J. D. Mennechet, Eric J. Kremer

The C. difficile clnRAB operon initiates adaptations to the host environment in response to LL-37

Emily C. Woods, Adrianne N. Edwards, Kevin O. Childress, Joshua B. Jones, Shonna M. McBride

An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model

James C. Romero-Masters, Makoto Ohashi, Reza Djavadian, Mark R. Eichelberg, Mitch Hayes, Jillian A. Bristol, Shidong Ma, Erik A. Ranheim, Jenny Gumperz, Eric C. Johannsen, Shannon C. Kenney

Diverse pathways of escape from all well-characterized VRC01-class broadly neutralizing HIV-1 antibodies

Yuka Otsuka, Kimberly Schmitt, Brian D. Quinlan, Matthew R. Gardner, Barnett Alfant, Adrian Reich, Michael Farzan, Hyeryun Choe

A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein

Chenxi Xu, Xing Liu, Huangyuan Zha, Sijia Fan, Dawei Zhang, Shan Li, Wuhan Xiao

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue

Dorota Kmiec, Bengisu Akbil, Swetha Ananth, Dominik Hotter, Konstantin M. J. Sparrer, Christina M. Stürzel, Birthe Trautz, Ahidjo Ayouba, Martine Peeters, Zhong Yao, Igor Stagljar, Vânia Passos, Thomas Zillinger, Christine Goffinet, Daniel Sauter, Oliver T. Fackler, Frank Kirchhoff

A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum

Sandra Bennink, Andreas von Bohl, Che J. Ngwa, Leonie Henschel, Andrea Kuehn, Nicole Pilch, Tim Weißbach, Alina N. Rosinski, Matthias Scheuermayer, Urska Repnik, Jude M. Przyborski, Allen M. Minns, Lindsey M. Orchard, Gareth Griffiths, Scott E. Lindner, Manuel Llinás, Gabriele Pradel

NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection

Shengfeng Hu, Xialin Du, Yulan Huang, Yuling Fu, Yalong Yang, Xiaoxia Zhan, Wenting He, Qian Wen, Xinying Zhou, Chaoying Zhou, Xiao-Ping Zhong, Jiahui Yang, Wenjing Xiong, Ruining Wang, Yuchi Gao, Li Ma

Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap

Philipp A. Ilinykh, Rodrigo I. Santos, Bronwyn M. Gunn, Natalia A. Kuzmina, Xiaoli Shen, Kai Huang, Pavlo Gilchuk, Andrew I. Flyak, Patrick Younan, Galit Alter, James E. Crowe Jr, Alexander Bukreyev

Pulmonary influenza A virus infection leads to suppression of the innate immune response to dermal injury

Meredith J. Crane, Yun Xu, William L. Henry Jr., Sean P. Gillis, Jorge E. Albina, Amanda M. Jamieson

Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing

Shouwen Chen, Dahai Yang, Ying Wen, Zhiwei Jiang, Lingzhi Zhang, Jiatiao Jiang, Yaozhen Chen, Tianjian Hu, Qiyao Wang, Yuanxing Zhang, Qin Liu

Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis

Chadi Zakaria, Polen Sean, Huy-Dung Hoang, Louis-Phillipe Leroux, Margaret Watson, Samuel Tekeste Workenhe, Jaclyn Hearnden, Dana Pearl, Vinh Tai Truong, Nathaniel Robichaud, Akiko Yanagiya, Soroush Tahmasebi, Seyed Mehdi Jafarnejad, Jian-Jun Jia, Adrian Pelin, Jean-Simon Diallo, Fabrice Le Boeuf, John Cameron Bell, Karen Louise Mossman, Tyson Ernst Graber, Maritza Jaramillo, Nahum Sonenberg, Tommy Alain

Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication

Krystelle Nganou-Makamdop, James M. Billingsley, Zachary Yaffe, Gregory O’Connor, Gregory K. Tharp, Amy Ransier, Farida Laboune, Rodrigo Matus-Nicodemos, Andrea Lerner, Lavina Gharu, Jennifer M. Robertson, Mandy L. Ford, Martin Schlapschy, Nadine Kuhn, Alexandra Lensch, Jeffrey Lifson, Martha Nason, Arne Skerra, Gideon Schreiber, Steven E. Bosinger, Daniel C. Douek

Protective antigenic sites in respiratory syncytial virus G attachment protein outside the central conserved and cysteine noose domains

Jeehyun Lee, Laura Klenow, Elizabeth M. Coyle, Hana Golding, Surender Khurana

Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus

Dylan Flather, Joseph H. C. Nguyen, Bert L. Semler, Paul D. Gershon

Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3

Kezhen Wang, Chunling Zou, Xiujuan Wang, Chenxiao Huang, Tingting Feng, Wen Pan, Qihan Wu, Penghua Wang, Jianfeng Dai

Phospholipid synthesis fueled by lipid droplets drives the structural development of poliovirus replication organelles

Ekaterina G. Viktorova, Jules A. Nchoutmboube, Lauren A. Ford-Siltz, Ethan Iverson, George A. Belov

Control of primary mouse cytomegalovirus infection in lung nodular inflammatory foci by cooperation of interferon-gamma expressing CD4 and CD8 T cells

Yvonne Lueder, Katrin Heller, Christiane Ritter, Kirsten A. Keyser, Karen Wagner, Xiaokun Liu, Martin Messerle, Felix R. Stahl, Stephan Halle, Reinhold Förster

Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm

Neima Briggs, Junfei Wei, Leroy Versteeg, Bin Zhan, Brian Keegan, Ashish Damania, Jeroen Pollet, Kelly S. Hayes, Coreen Beaumier, Christopher A. Seid, Jamie Leong, Richard K. Grencis, Maria Elena Bottazzi, K. Jagannadha Sastry, Peter J. Hotez

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7

Sakaorat Lertjuthaporn, Claudia Cicala, Donald Van Ryk, Matthew Liu, Jason Yolitz, Danlan Wei, Fatima Nawaz, Allison Doyle, Brooke Horowitch, Chung Park, Shan Lu, Yang Lou, Shixia Wang, Ruimin Pan, Xunqing Jiang, Francois Villinger, Siddappa N. Byrareddy, Philip J. Santangelo, Lynn Morris, Constantinos Kurt Wibmer, Kristin Biris, Rosemarie D. Mason, Jason Gorman, Joseph Hiatt, Elena Martinelli, Mario Roederer, Dai Fujikawa, Giacomo Gorini, Genoveffa Franchini, Anush Arakelyan, Aftab A. Ansari, Kovit Pattanapanyasat, Xiang-Peng Kong, Anthony S. Fauci, James Arthos

Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase

Asigul Ismayil, Yakupjan Haxim, Yunjing Wang, Huangai Li, Lichao Qian, Ting Han, Tianyuan Chen, Qi Jia, Alexander Yihao Liu, Songbiao Zhu, Haiteng Deng, Rena Gorovits, Yiguo Hong, Linda Hanley-Bowdoin, Yule Liu