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Table of Contents

October 2016

Mucosal inflammation is visualized in bladder sections from Asc-/- mice, infected with uropathogenic E. coli. Infection triggered a massive recruitment of neutrophils (red) to the mucosa. In susceptible mice, large numbers of bacteria were detected in the mucosa (green) and were shown to colocalize with neutrophil aggregates in micro-abscesses (yellow). Frozen tissue sections were stained for immunohistochemistry with specific antibodies to neutrophils and E. coli. Nuclei were counterstained with DAPI (cyan). Ambite et al.

Image Credit: Manoj Puthia, Biomedical Centre, Lund University, Sweden

Opinion

Pearls

Community-Associated Methicillin-Resistant Staphylococcus aureus: An Enemy amidst Us

Eric F. Kong, Jennifer K. Johnson, Mary Ann Jabra-Rizk

Carrion’s Disease: More Than a Sand Fly–Vectored Illness

Maria J. Pons, Cláudia Gomes, Juana del Valle-Mendoza, Joaquim Ruiz

The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage

Duncan Wilson, Julian R. Naglik, Bernhard Hube

Building Viral Replication Organelles: Close Encounters of the Membrane Types

Peter D. Nagy, Jeroen R. P. M. Strating, Frank J. M. van Kuppeveld

Review

Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis

Fumika Mi-ichi, Hiroki Yoshida, Shinjiro Hamano

Research Articles

Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi

Catherine W. Cai, Jennifer R. Blase, Xiuli Zhang, Christopher S. Eickhoff, Daniel F. Hoft

Regulation of the Abundance of Kaposi’s Sarcoma-Associated Herpesvirus ORF50 Protein by Oncoprotein MDM2

Tzu-Hsuan Chang, Shie-Shan Wang, Lee-Wen Chen, Ying-Ju Shih, Li-Kwan Chang, Shih-Tung Liu, Pey-Jium Chang

The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2

Marsha DeSmet, Sriramana Kanginakudru, Anne Rietz, Wai-Hong Wu, Richard Roden, Elliot J. Androphy

Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex

Siyuan Ding, Nancie Mooney, Bin Li, Marcus R. Kelly, Ningguo Feng, Alexander V. Loktev, Adrish Sen, John T. Patton, Peter K. Jackson, Harry B. Greenberg

XRN1 Is a Species-Specific Virus Restriction Factor in Yeasts

Paul A. Rowley, Brandon Ho, Sarah Bushong, Arlen Johnson, Sara L. Sawyer

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Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages

Punsiri M. Colonne, Caylin G. Winchell, Joseph G. Graham, Frances I. Onyilagha, Laura J. MacDonald, Heike R. Doeppler, Peter Storz, Richard C. Kurten, Paul A. Beare, Robert A. Heinzen, Daniel E. Voth

Magnaporthe oryzae Glycine-Rich Secretion Protein, Rbf1 Critically Participates in Pathogenicity through the Focal Formation of the Biotrophic Interfacial Complex

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Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier

Xiangru Wang, Ravi Maruvada, Andrew J. Morris, Jun O. Liu, Michael J. Wolfgang, Dong Jae Baek, Robert Bittman, Kwang Sik Kim

Distinct Effects of p19 RNA Silencing Suppressor on Small RNA Mediated Pathways in Plants

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Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection

Brodie Miles, Shannon M. Miller, Joy M. Folkvord, David N. Levy, Eva G. Rakasz, Pamela J. Skinner, Elizabeth Connick

Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model

Xiangyu Yao, Jian Wu, Meng Lin, Wenxiang Sun, Xiao He, Channe Gowda, Silvia Bolland, Carole A. Long, Rongfu Wang, Xin-zhuan Su

Clinically Relevant Reactivation of Polyomavirus BK (BKPyV) in HLA-A02-Positive Renal Transplant Recipients Is Associated with Impaired Effector-Memory Differentiation of BKPyV-Specific CD8+ T Cells

Michiel C. van Aalderen, Ester B. M. Remmerswaal, Kirstin M. Heutinck, Anja ten Brinke, Mariet C. W. Feltkamp, Neelke C. van der Weerd, Karlijn A. M. I. van der Pant, Frederike J. Bemelman, René A. W. van Lier, Ineke J. M. ten Berge

CdiA Effectors from Uropathogenic Escherichia coli Use Heterotrimeric Osmoporins as Receptors to Recognize Target Bacteria

Christina M. Beck, Julia L. E. Willett, David A. Cunningham, Jeff J. Kim, David A. Low, Christopher S. Hayes

Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets

Ines Ambite, Manoj Puthia, Karoly Nagy, Caterina Cafaro, Aftab Nadeem, Daniel S. C. Butler, Gustav Rydström, Nina A. Filenko, Björn Wullt, Thomas Miethke, Catharina Svanborg

A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses

Cristina J. Wittkopp, Madison B. Adolph, Lily I. Wu, Linda Chelico, Michael Emerman

Single Cell Bottlenecks in the Pathogenesis of Streptococcus pneumoniae

Masamitsu Kono, M. Ammar Zafar, Marisol Zuniga, Aoife M. Roche, Shigeto Hamaguchi, Jeffrey N. Weiser

Combined Activity of DCL2 and DCL3 Is Crucial in the Defense against Potato Spindle Tuber Viroid

Konstantina Katsarou, Eleni Mavrothalassiti, Wannes Dermauw, Thomas Van Leeuwen, Kriton Kalantidis

Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria

Ryan A. Zander, Jenna J. Guthmiller, Amy C. Graham, Rosemary L. Pope, Bradly E. Burke, Daniel J.J. Carr, Noah S. Butler

Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus

Jennifer L. Uhrlaub, Vesna Pulko, Victor R. DeFilippis, Rebecca Broeckel, Daniel N. Streblow, Gary D. Coleman, Byung S. Park, John F. Lindo, Ivan Vickers, Joshua J. Anzinger, Janko Nikolich-Žugich

An RNAi-Based Control of Fusarium graminearum Infections Through Spraying of Long dsRNAs Involves a Plant Passage and Is Controlled by the Fungal Silencing Machinery

Aline Koch, Dagmar Biedenkopf, Alexandra Furch, Lennart Weber, Oliver Rossbach, Eltayb Abdellatef, Lukas Linicus, Jan Johannsmeier, Lukas Jelonek, Alexander Goesmann, Vinitha Cardoza, John McMillan, Tobias Mentzel, Karl-Heinz Kogel

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death

Naomi H. Philip, Alexandra DeLaney, Lance W. Peterson, Melanie Santos-Marrero, Jennifer T. Grier, Yan Sun, Meghan A. Wynosky-Dolfi, Erin E. Zwack, Baofeng Hu, Tayla M. Olsen, Anthony Rongvaux, Scott D. Pope, Carolina B. López, Andrew Oberst, Daniel P. Beiting, Jorge Henao-Mejia, Igor E. Brodsky

Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model

Susanna K. P. Lau, Patrick C. Y. Woo, Kenneth S. M. Li, Hao-Ji Zhang, Rachel Y. Y. Fan, Anna J. X. Zhang, Brandon C. C. Chan, Carol S. F. Lam, Cyril C. Y. Yip, Ming-Chi Yuen, Kwok-Hung Chan, Zhi-Wei Chen, Kwok-Yung Yuen

A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence

Michele Chu, Michael J. G. Mallozzi, Bryan P. Roxas, Lisa Bertolo, Mario A. Monteiro, Al Agellon, V. K. Viswanathan, Gayatri Vedantam

Rabies Virus Infection Induces the Formation of Stress Granules Closely Connected to the Viral Factories

Jovan Nikolic, Ahmet Civas, Zoé Lama, Cécile Lagaudrière-Gesbert, Danielle Blondel

The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis

Robert N. Kirchdoerfer, Crystal L. Moyer, Dafna M. Abelson, Erica Ollmann Saphire

Kingella kingae Expresses Four Structurally Distinct Polysaccharide Capsules That Differ in Their Correlation with Invasive Disease

Kimberly F. Starr, Eric A. Porsch, Patrick C. Seed, Christian Heiss, Radnaa Naran, L. Scott Forsberg, Uri Amit, Pablo Yagupsky, Parastoo Azadi, Joseph W. St. Geme III

Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs

Marissa B. Guzzo, Hoa T. Nguyen, Thanh H. Pham, Monika Wyszczelska-Rokiel, Hieronim Jakubowski, Kerstin A. Wolff, Sam Ogwang, Joseph L. Timpona, Soumya Gogula, Michael R. Jacobs, Markus Ruetz, Bernhard Kräutler, Donald W. Jacobsen, Guo-Fang Zhang, Liem Nguyen

Pyruvate Oxidase as a Critical Link between Metabolism and Capsule Biosynthesis in Streptococcus pneumoniae

Haley Echlin, Matthew W. Frank, Amy Iverson, Ti-Cheng Chang, Michael D. L. Johnson, Charles O. Rock, Jason W. Rosch

Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals

Qian Qi, Mary M. Cavanagh, Sabine Le Saux, Lisa E. Wagar, Sally Mackey, Jinyu Hu, Holden Maecker, Gary E. Swan, Mark M. Davis, Cornelia L. Dekker, Lu Tian, Cornelia M. Weyand, Jörg J. Goronzy

HIV-1 Integrates Widely throughout the Genome of the Human Blood Fluke Schistosoma mansoni

Sutas Suttiprapa, Gabriel Rinaldi, Isheng J. Tsai, Victoria H. Mann, Larisa Dubrovsky, Hong-bin Yan, Nancy Holroyd, Thomas Huckvale, Caroline Durrant, Anna V. Protasio, Tatiana Pushkarsky, Sergey Iordanskiy, Matthew Berriman, Michael I. Bukrinsky, Paul J. Brindley

An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4

Ke Ren, Wei Zhang, Xiaoqing Chen, Yingyu Ma, Yue Dai, Yimei Fan, Yayi Hou, Ren Xiang Tan, Erguang Li

ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi’s Sarcoma-Associated Herpesvirus

Binod Kumar, Dipanjan Dutta, Jawed Iqbal, Mairaj Ahmed Ansari, Arunava Roy, Leela Chikoti, Gina Pisano, Mohanan Valiya Veettil, Bala Chandran

Histone H2B-IFI16 Recognition of Nuclear Herpesviral Genome Induces Cytoplasmic Interferon-β Responses

Jawed Iqbal, Mairaj Ahmed Ansari, Binod Kumar, Dipanjan Dutta, Arunava Roy, Leela Chikoti, Gina Pisano, Sujoy Dutta, Shahrooz Vahedi, Mohanan Valiya Veettil, Bala Chandran

The Tax-Inducible Actin-Bundling Protein Fascin Is Crucial for Release and Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1 (HTLV-1)

Christine Gross, Veit Wiesmann, Sebastian Millen, Martina Kalmer, Thomas Wittenberg, Jan Gettemans, Andrea K. Thoma-Kress

Additive Promotion of Viral Internal Ribosome Entry Site-Mediated Translation by Far Upstream Element-Binding Protein 1 and an Enterovirus 71-Induced Cleavage Product

Chuan-Tien Hung, Yu-An Kung, Mei-Ling Li, Gary Brewer, Kuo-Ming Lee, Shih-Tung Liu, Shin-Ru Shih

The Drosophila CD36 Homologue croquemort Is Required to Maintain Immune and Gut Homeostasis during Development and Aging

Aurélien Guillou, Katia Troha, Hui Wang, Nathalie C. Franc, Nicolas Buchon

A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists

Kathryn S. Carpentier, Nicolle M. Esparo, Stephanie J. Child, Adam P. Geballe

Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc

Pablo Guardado-Calvo, Eduardo A. Bignon, Eva Stettner, Scott Allen Jeffers, Jimena Pérez-Vargas, Gerard Pehau-Arnaudet, M. Alejandra Tortorici, Jean-Luc Jestin, Patrick England, Nicole D. Tischler, Félix A. Rey

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NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection

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Dual microRNA Screens Reveal That the Immune-Responsive miR-181 Promotes Henipavirus Entry and Cell-Cell Fusion

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The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria

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A Viral Immunity Chromosome in the Marine Picoeukaryote, Ostreococcus tauri

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