June 2013

Compared to the important effort devoted to the genetic and molecular study of the ability of mosquitoes to transmit malaria parasites, relatively few studies have considered the ecological context in which mosquitoes and parasites interact. Recent studies reveal a great diversity of ways in which environmental conditions interfere with the mosquito immune response and parasite development, with far-reaching evolutionary and epidemiological implications. However, much research remains to be done. For example, in addition to feeding on blood, malaria vectors readily use natural plant nectars as sources of energy. Whether natural plant diversity affects mosquito competence for malaria parasites remains to be discovered. See Lefèvre et al.

Image Credit: Thierry Lefèvre

Opinion

Introducing the Outbreak Threshold in Epidemiology

Matthew Hartfield, Samuel Alizon

PLOS Pathogens: published June 6, 2013 | https://doi.org/10.1371/journal.ppat.1003277

Pearls

The Spatial Organization of DNA Virus Genomes in the Nucleus

Roger D. Everett

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003386

Developing Models of Disease Transmission: Insights from Ecological Studies of Insects and Their Baculoviruses

Bret D. Elderd

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003372

Asthma and the Diversity of Fungal Spores in Air

Anne Pringle

PLOS Pathogens: published June 6, 2013 | https://doi.org/10.1371/journal.ppat.1003371

Review

Non-Genetic Determinants of Mosquito Competence for Malaria Parasites

Thierry Lefèvre, Amélie Vantaux, Kounbobr R. Dabiré, Karine Mouline, Anna Cohuet

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003365

Research Articles

Hepatitis B Virus Induces IL-23 Production in Antigen Presenting Cells and Causes Liver Damage via the IL-23/IL-17 Axis

Qinghong Wang, Jijun Zhou, Bei Zhang, Zhiqiang Tian, Jun Tang, Yanhua Zheng, Zemin Huang, Yi Tian, Zhengcai Jia, Yan Tang, Jennifer C. van Velkinburgh, Qing Mao, Xiuwu Bian, Yifang Ping, Bing Ni, Yuzhang Wu

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003410

A Novel Two-Component Signaling System Facilitates Uropathogenic Escherichia coli's Ability to Exploit Abundant Host Metabolites

Wentong Cai, Yvonne Wannemuehler, Giuseppe Dell'Anna, Bryon Nicholson, Nicolle L. Barbieri, Subhashinie Kariyawasam, Yaping Feng, Catherine M. Logue, Lisa K. Nolan, Ganwu Li

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003428

DC8 and DC13 var Genes Associated with Severe Malaria Bind Avidly to Diverse Endothelial Cells

Marion Avril, Andrew J. Brazier, Martin Melcher, Sowmya Sampath, Joseph D. Smith

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003430

Multifunctional Double-negative T Cells in Sooty Mangabeys Mediate T-helper Functions Irrespective of SIV Infection

Vasudha Sundaravaradan, Ramsey Saleem, Luca Micci, Melanie A. Gasper, Alexandra M. Ortiz, James Else, Guido Silvestri, Mirko Paiardini, John D. Aitchison, Donald L. Sodora

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003441

Bruton's Tyrosine Kinase (BTK) and Vav1 Contribute to Dectin1-Dependent Phagocytosis of Candida albicans in Macrophages

Karin Strijbis, Fikadu G. Tafesse, Gregory D. Fairn, Martin D. Witte, Stephanie K. Dougan, Nicki Watson, Eric Spooner, Alexandre Esteban, Valmik K. Vyas, Gerald R. Fink, Sergio Grinstein, Hidde L. Ploegh

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003446

Novel Immunomodulators from Hard Ticks Selectively Reprogramme Human Dendritic Cell Responses

Stephen G. Preston, Juraj Majtán, Chrisoula Kouremenou, Oliwia Rysnik, Lena F. Burger, Alejandro Cabezas Cruz, Maylin Chiong Guzman, Miles A. Nunn, Guido C. Paesen, Patricia A. Nuttall, Jonathan M. Austyn

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003450

miR-182 and miR-10a Are Key Regulators of Treg Specialisation and Stability during Schistosome and Leishmania-associated Inflammation

Samir Kelada, Praveen Sethupathy, Isobel S. Okoye, Eleni Kistasis, Stephanie Czieso, Sandra D. White, David Chou, Craig Martens, Stacy M. Ricklefs, Kimmo Virtaneva, Dan E. Sturdevant, Stephen F. Porcella, Yasmine Belkaid, Thomas A. Wynn, Mark S. Wilson

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003451

CYLD Enhances Severe Listeriosis by Impairing IL-6/STAT3-Dependent Fibrin Production

Gopala Nishanth, Martina Deckert, Katharina Wex, Ramin Massoumi, Katrin Schweitzer, Michael Naumann, Dirk Schlüter

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003455

Dietary Cholesterol Modulates Pathogen Blocking by Wolbachia

Eric P. Caragata, Edwige Rancès, Lauren M. Hedges, Alexander W. Gofton, Karyn N. Johnson, Scott L. O'Neill, Elizabeth A. McGraw

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003459

Cellular RNA Binding Proteins NS1-BP and hnRNP K Regulate Influenza A Virus RNA Splicing

Pei-Ling Tsai, Ni-Ting Chiou, Sharon Kuss, Adolfo García-Sastre, Kristen W. Lynch, Beatriz M. A. Fontoura

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003460

Critical Significance of the Region between Helix 1 and 2 for Efficient Dominant-Negative Inhibition by Conversion-Incompetent Prion Protein

Yuzuru Taguchi, Arla M. A. Mistica, Tetsuyuki Kitamoto, Hermann M. Schätzl

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003466

A Type IV Pilus Mediates DNA Binding during Natural Transformation in Streptococcus pneumoniae

Raphaël Laurenceau, Gérard Péhau-Arnaudet, Sonia Baconnais, Joseph Gault, Christian Malosse, Annick Dujeancourt, Nathalie Campo, Julia Chamot-Rooke, Eric Le Cam, Jean-Pierre Claverys, Rémi Fronzes

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003473

Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L

Frédéric Sorgeloos, Babal Kant Jha, Robert H. Silverman, Thomas Michiels

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003474

Deciphering the Cryptic Genome: Genome-wide Analyses of the Rice Pathogen Fusarium fujikuroi Reveal Complex Regulation of Secondary Metabolism and Novel Metabolites

Philipp Wiemann, Christian M. K. Sieber, Katharina W. von Bargen, Lena Studt, Eva-Maria Niehaus, Jose J. Espino, Kathleen Huß, Caroline B. Michielse, Sabine Albermann, Dominik Wagner, Sonja V. Bergner, Lanelle R. Connolly, Andreas Fischer, Gunter Reuter, Karin Kleigrewe, Till Bald, Brenda D. Wingfield, Ron Ophir, Stanley Freeman, Michael Hippler, Kristina M. Smith, Daren W. Brown, Robert H. Proctor, Martin Münsterkötter, Michael Freitag, Hans-Ulrich Humpf, Ulrich Güldener, Bettina Tudzynski

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003475

T Cell-Derived IL-10 Determines Leishmaniasis Disease Outcome and Is Suppressed by a Dendritic Cell Based Vaccine

Tobias Schwarz, Katharina A. Remer, Wiebke Nahrendorf, Anita Masic, Lisa Siewe, Werner Müller, Axel Roers, Heidrun Moll

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003476

Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6

Xing Liu, Wei Chen, Qiang Wang, Li Li, Chen Wang

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003480

Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells

Joseph A. Hollenbaugh, Peter Gee, Jonathon Baker, Michele B. Daly, Sarah M. Amie, Jessica Tate, Natsumi Kasai, Yuka Kanemura, Dong-Hyun Kim, Brian M. Ward, Yoshio Koyanagi, Baek Kim

PLOS Pathogens: published June 27, 2013 | https://doi.org/10.1371/journal.ppat.1003481

Rickettsia typhi Possesses Phospholipase A₂ Enzymes that Are Involved in Infection of Host Cells

M. Sayeedur Rahman, Joseph J. Gillespie, Simran Jeet Kaur, Khandra T. Sears, Shane M. Ceraul, Magda Beier-Sexton, Abdu F. Azad

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003399

HIV-1 Vaccine-Induced T-Cell Reponses Cluster in Epitope Hotspots that Differ from Those Induced in Natural Infection with HIV-1

Tomer Hertz, Hasan Ahmed, David P. Friedrich, Danilo R. Casimiro, Steven G. Self, Lawrence Corey, M. Juliana McElrath, Susan Buchbinder, Helen Horton, Nicole Frahm, Michael N. Robertson, Barney S. Graham, Peter Gilbert

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003404

Adhesins and Host Serum Factors Drive Yop Translocation by Yersinia into Professional Phagocytes during Animal Infection

Francisco J. Maldonado-Arocho, Carlos Green, Michael L. Fisher, Michelle K. Paczosa, Joan Mecsas

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003415

Galectin-9 and IL-21 Mediate Cross-regulation between Th17 and Treg Cells during Acute Hepatitis C

Hassen Kared, Thomas Fabre, Nathalie Bédard, Julie Bruneau, Naglaa H. Shoukry

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003422

Novel Polyomaviruses of Nonhuman Primates: Genetic and Serological Predictors for the Existence of Multiple Unknown Polyomaviruses within the Human Population

Nelly Scuda, Nadege Freda Madinda, Chantal Akoua-Koffi, Edgard Valerie Adjogoua, Diana Wevers, Jörg Hofmann, Kenneth N. Cameron, Siv Aina J. Leendertz, Emmanuel Couacy-Hymann, Martha Robbins, Christophe Boesch, Michael A. Jarvis, Ugo Moens, Lawrence Mugisha, Sébastien Calvignac-Spencer, Fabian H. Leendertz, Bernhard Ehlers

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003429

Single Cell Analysis of Lymph Node Tissue from HIV-1 Infected Patients Reveals that the Majority of CD4⁺ T-cells Contain One HIV-1 DNA Molecule

Lina Josefsson, Sarah Palmer, Nuno R. Faria, Philippe Lemey, Joseph Casazza, David Ambrozak, Mary Kearney, Wei Shao, Shyamasundaran Kottilil, Michael Sneller, John Mellors, John M. Coffin, Frank Maldarelli

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003432

Evidence for Novel Hepaciviruses in Rodents

Jan Felix Drexler, Victor Max Corman, Marcel Alexander Müller, Alexander N. Lukashev, Anatoly Gmyl, Bruno Coutard, Alexander Adam, Daniel Ritz, Lonneke M. Leijten, Debby van Riel, Rene Kallies, Stefan M. Klose, Florian Gloza-Rausch, Tabea Binger, Augustina Annan, Yaw Adu-Sarkodie, Samuel Oppong, Mathieu Bourgarel, Daniel Rupp, Bernd Hoffmann, Mathias Schlegel, Beate M. Kümmerer, Detlev H. Krüger, Jonas Schmidt-Chanasit, Alvaro Aguilar Setién, Veronika M. Cottontail, Thiravat Hemachudha, Supaporn Wacharapluesadee, Klaus Osterrieder, Ralf Bartenschlager, Sonja Matthee, Martin Beer, Thijs Kuiken, Chantal Reusken, Eric M. Leroy, Rainer G. Ulrich, Christian Drosten

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003438

Heterosubtypic Immunity to Influenza A Virus Infections in Mallards May Explain Existence of Multiple Virus Subtypes

Neus Latorre-Margalef, Vladimir Grosbois, John Wahlgren, Vincent J. Munster, Conny Tolf, Ron A. M. Fouchier, Albert D. M. E. Osterhaus, Björn Olsen, Jonas Waldenström

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003443

Nitric Oxide Synthase Dysfunction Contributes to Impaired Cerebroarteriolar Reactivity in Experimental Cerebral Malaria

Peng Kai Ong, Benoît Melchior, Yuri C. Martins, Anthony Hofer, Pamela Orjuela-Sánchez, Pedro Cabrales, Graziela M. Zanini, John A. Frangos, Leonardo J. M. Carvalho

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003444

An Extracellular Subtilase Switch for Immune Priming in Arabidopsis

Vicente Ramírez, Ana López, Brigitte Mauch-Mani, Ma José Gil, Pablo Vera

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003445

Location of the CD8 T Cell Epitope within the Antigenic Precursor Determines Immunogenicity and Protection against the Toxoplasma gondii Parasite

Virginie Feliu, Virginie Vasseur, Harshita S. Grover, H. Hamlet Chu, Mark J. Brown, Jeremy Wang, Jon P. Boyle, Ellen A. Robey, Nilabh Shastri, Nicolas Blanchard

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003449

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

Joseph Chavarría-Smith, Russell E. Vance

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003452

The Th17/Treg Ratio, IL-1RA and sCD14 Levels in Primary HIV Infection Predict the T-cell Activation Set Point in the Absence of Systemic Microbial Translocation

Mathieu F. Chevalier, Gaël Petitjean, Catherine Dunyach-Rémy, Céline Didier, Pierre-Marie Girard, Maria Elena Manea, Pauline Campa, Laurence Meyer, Christine Rouzioux, Jean-Philippe Lavigne, Françoise Barré-Sinoussi, Daniel Scott-Algara, Laurence Weiss

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003453

CD4⁺ T Cell-derived IL-10 Promotes Brucella abortus Persistence via Modulation of Macrophage Function

Mariana N. Xavier, Maria G. Winter, Alanna M. Spees, Kim Nguyen, Vidya L. Atluri, Teane M. A. Silva, Andreas J. Bäumler, Werner Müller, Renato L. Santos, Renée M. Tsolis

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003454

Dissection of Antibody Specificities Induced by Yellow Fever Vaccination

Oksana Vratskikh, Karin Stiasny, Jürgen Zlatkovic, Georgios Tsouchnikas, Johanna Jarmer, Urs Karrer, Michael Roggendorf, Hedwig Roggendorf, Regina Allwinn, Franz X. Heinz

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003458

Extreme Genetic Fragility of the HIV-1 Capsid

Suzannah J. Rihn, Sam J. Wilson, Nick J. Loman, Mudathir Alim, Saskia E. Bakker, David Bhella, Robert J. Gifford, Frazer J. Rixon, Paul D. Bieniasz

PLOS Pathogens: published June 20, 2013 | https://doi.org/10.1371/journal.ppat.1003461

Bacterial Cytolysin during Meningitis Disrupts the Regulation of Glutamate in the Brain, Leading to Synaptic Damage

Carolin Wippel, Jana Maurer, Christina Förtsch, Sabrina Hupp, Alexandra Bohl, Jiangtao Ma, Timothy J. Mitchell, Stephanie Bunkowski, Wolfgang Brück, Roland Nau, Asparouh I. Iliev

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003380

Combination of DNA Prime – Adenovirus Boost Immunization with Entecavir Elicits Sustained Control of Chronic Hepatitis B in the Woodchuck Model

Anna D. Kosinska, Ejuan Zhang, Lena Johrden, Jia Liu, Pia L. Seiz, Xiaoyong Zhang, Zhiyong Ma, Thekla Kemper, Melanie Fiedler, Dieter Glebe, Oliver Wildner, Ulf Dittmer, Mengji Lu, Michael Roggendorf

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003391

Host Defense and Recruitment of Foxp3⁺ T Regulatory Cells to the Lungs in Chronic Mycobacterium tuberculosis Infection Requires Toll-like Receptor 2

Amanda McBride, Jill Konowich, Padmini Salgame

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003397

The Escherichia coli Phosphotyrosine Proteome Relates to Core Pathways and Virulence

Anne-Marie Hansen, Raghothama Chaerkady, Jyoti Sharma, J. Javier Díaz-Mejía, Nidhi Tyagi, Santosh Renuse, Harrys K. C. Jacob, Sneha M. Pinto, Nandini A. Sahasrabuddhe, Min-Sik Kim, Bernard Delanghe, Narayanaswamy Srinivasan, Andrew Emili, James B. Kaper, Akhilesh Pandey

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003403

Viral Retasking of hBre1/RNF20 to Recruit hPaf1 for Transcriptional Activation

Gregory J. Fonseca, Michael J. Cohen, Anthony C. Nichols, John W. Barrett, Joe S. Mymryk

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003411

Efficient Sensing of Infected Cells in Absence of Virus Particles by Blasmacytoid Dendritic Cells Is Blocked by the Viral Ribonuclease E^rns

Sylvie Python, Markus Gerber, Rolf Suter, Nicolas Ruggli, Artur Summerfield

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003412

IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

Arun K. Haldar, Hector A. Saka, Anthony S. Piro, Joe Dan Dunn, Stanley C. Henry, Gregory A. Taylor, Eva M. Frickel, Raphael H. Valdivia, Jörn Coers

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003414

Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses

Martin Baril, Salwa Es-Saad, Laurent Chatel-Chaix, Karin Fink, Tram Pham, Valérie-Ann Raymond, Karine Audette, Anne-Sophie Guenier, Jean Duchaine, Marc Servant, Marc Bilodeau, Éric Cohen, Nathalie Grandvaux, Daniel Lamarre

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003416

Glycan Masking of Plasmodium vivax Duffy Binding Protein for Probing Protein Binding Function and Vaccine Development

Sowmya Sampath, Chris Carrico, Joel Janes, Sairam Gurumoorthy, Claire Gibson, Martin Melcher, Chetan E. Chitnis, Ruobing Wang, William R. Schief, Joseph D. Smith

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003420

Influenza Virus Reassortment Occurs with High Frequency in the Absence of Segment Mismatch

Nicolle Marshall, Lalita Priyamvada, Zachary Ende, John Steel, Anice C. Lowen

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003421

Identification of a Novel Antimicrobial Peptide from Human Hepatitis B Virus Core Protein Arginine-Rich Domain (ARD)

Heng-Li Chen, Pei-Yi Su, Ya-Shu Chang, Szu-Yao Wu, You-Di Liao, Hui-Ming Yu, Tsai-Ling Lauderdale, Kaichih Chang, Chiaho Shih

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003425

An Apicoplast Localized Ubiquitylation System Is Required for the Import of Nuclear-encoded Plastid Proteins

Swati Agrawal, Duk-Won D. Chung, Nadia Ponts, Giel G. van Dooren, Jacques Prudhomme, Carrie F. Brooks, Elisadra M. Rodrigues, John C. Tan, Michael T. Ferdig, Boris Striepen, Karine G. Le Roch

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003426

The Xanthomonas campestris Type III Effector XopJ Targets the Host Cell Proteasome to Suppress Salicylic-Acid Mediated Plant Defence

Suayib Üstün, Verena Bartetzko, Frederik Börnke

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003427

Sub-Inhibitory Concentrations of Human α-defensin Potentiate Neutralizing Antibodies against HIV-1 gp41 Pre-Hairpin Intermediates in the Presence of Serum

Lusine Demirkhanyan, Mariana Marin, Wuyuan Lu, Gregory B. Melikyan

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003431

Extreme Resistance as a Host Counter-counter Defense against Viral Suppression of RNA Silencing

Raphaël Sansregret, Vanessa Dufour, Mathieu Langlois, Fouad Daayf, Patrice Dunoyer, Olivier Voinnet, Kamal Bouarab

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003435

Transcriptome Analyses of Inhibitor-treated Schistosome Females Provide Evidence for Cooperating Src-kinase and TGFβ Receptor Pathways Controlling Mitosis and Eggshell Formation

Christin Buro, Katia C. Oliveira, Zhigang Lu, Silke Leutner, Svenja Beckmann, Colette Dissous, Katia Cailliau, Sergio Verjovski-Almeida, Christoph G. Grevelding

PLOS Pathogens: published June 13, 2013 | https://doi.org/10.1371/journal.ppat.1003448

Global Expression Profiling of Transcription Factor Genes Provides New Insights into Pathogenicity and Stress Responses in the Rice Blast Fungus

Sook-Young Park, Jaeyoung Choi, Se-Eun Lim, Gir-Won Lee, Jongsun Park, Yang Kim, Sunghyung Kong, Se Ryun Kim, Hee-Sool Rho, Junhyun Jeon, Myung-Hwan Chi, Soonok Kim, Chang Hyun Khang, Seogchan Kang, Yong-Hwan Lee

PLOS Pathogens: published June 6, 2013 | https://doi.org/10.1371/journal.ppat.1003350

Crosstalk between the Circadian Clock and Innate Immunity in Arabidopsis

Chong Zhang, Qiguang Xie, Ryan G. Anderson, Gina Ng, Nicholas C. Seitz, Thomas Peterson, C. Robertson McClung, John M. McDowell, Dongdong Kong, June M. Kwak, Hua Lu

PLOS Pathogens: published June 6, 2013 | https://doi.org/10.1371/journal.ppat.1003370

Streptolysin O and its Co-Toxin NAD-glycohydrolase Protect Group A Streptococcus from Xenophagic Killing

Maghnus O'Seaghdha, Michael R. Wessels

PLOS Pathogens: published June 6, 2013 | https://doi.org/10.1371/journal.ppat.1003394

Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol

Cierra N. Casson, Alan M. Copenhaver, Erin E. Zwack, Hieu T. Nguyen, Till Strowig, Bahar Javdan, William P. Bradley, Thomas C. Fung, Richard A. Flavell, Igor E. Brodsky, Sunny Shin

PLOS Pathogens: published June 6, 2013 | https://doi.org/10.1371/journal.ppat.1003400

Increased Long Chain acyl-Coa Synthetase Activity and Fatty Acid Import Is Linked to Membrane Synthesis for Development of Picornavirus Replication Organelles

Jules A. Nchoutmboube, Ekaterina G. Viktorova, Alison J. Scott, Lauren A. Ford, Zhengtong Pei, Paul A. Watkins, Robert K. Ernst, George A. Belov

PLOS Pathogens: published June 6, 2013 | https://doi.org/10.1371/journal.ppat.1003401

The Stable Association of Virion with the Triple-gene-block Protein 3-based Complex of Bamboo mosaic virus

Yuan-Lin Chou, Yi-Jing Hung, Yang-Hao Tseng, Hsiu-Ting Hsu, Jun-Yi Yang, Chiung-Hua Wung, Na-Sheng Lin, Menghsiao Meng, Yau-Heiu Hsu, Ban-Yang Chang

PLOS Pathogens: published June 6, 2013 | https://doi.org/10.1371/journal.ppat.1003405

Extramedullary Myelopoiesis in Malaria Depends on Mobilization of Myeloid-Restricted Progenitors by IFN-γ Induced Chemokines

Nikolai N. Belyaev, Judit Biró, Jean Langhorne, Alexandre J. Potocnik

PLOS Pathogens: published June 6, 2013 | https://doi.org/10.1371/journal.ppat.1003406

Vitamin D Induces Interleukin-1β Expression: Paracrine Macrophage Epithelial Signaling Controls M. tuberculosis Infection

Mark Verway, Manuella Bouttier, Tian-Tian Wang, Marilyn Carrier, Mario Calderon, Beum-Soo An, Emmanuelle Devemy, Fiona McIntosh, Maziar Divangahi, Marcel A. Behr, John H. White

PLOS Pathogens: published June 6, 2013 | https://doi.org/10.1371/journal.ppat.1003407

The Systemic Immune State of Super-shedder Mice Is Characterized by a Unique Neutrophil-dependent Blunting of T_H1 Responses

Smita Gopinath, Andrew Hotson, Jennifer Johns, Garry Nolan, Denise Monack

PLOS Pathogens: published June 6, 2013 | https://doi.org/10.1371/journal.ppat.1003408

Shigella IpaH0722 E3 Ubiquitin Ligase Effector Targets TRAF2 to Inhibit PKC–NF-κB Activity in Invaded Epithelial Cells

Hiroshi Ashida, Hiroyasu Nakano, Chihiro Sasakawa

PLOS Pathogens: published June 6, 2013 | https://doi.org/10.1371/journal.ppat.1003409

Cryotomography of Budding Influenza A Virus Reveals Filaments with Diverse Morphologies that Mostly Do Not Bear a Genome at Their Distal End

Swetha Vijayakrishnan, Colin Loney, David Jackson, Worawit Suphamungmee, Frazer J. Rixon, David Bhella

PLOS Pathogens: published June 6, 2013 | https://doi.org/10.1371/journal.ppat.1003413

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A female Anopheles gambiae, the world's most important vector of human malaria, resting on a flower of the flame tree, Caesalpinia pulcherrima

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