September 29, 2026

Selective serotonin reuptake inhibitors and immune checkpoint blockade in solid tumors: A target trial emulation with pan-cancer transcriptomic analyses

In this target trial emulation, Po-Huang Chen and colleagues compare outcomes associated with use of selective serotonin reuptake inhibitors or benzodiazepines in patients with solid tumors and depression or anxiety and find that patients receiving immune checkpoint inhibitors who initiated selective serotonin reuptake inhibitors had lower mortality than those initiating benzodiazepines.

Image credit: National Cancer Institute, Unsplash

10/07/2026

Research Article

Potential health impacts and costs of active case finding guided by Mycobacterium tuberculosis immunoreactivity survey results in Blantyre, Malawi: A mathematical modeling study

In this modelling study, Sun Kim and colleagues explore whether tuberculosis active case finding can be more efficiently targeted using local Mycobacterium tuberculosis immunoreactivity survey data from children in Blantyre, Malawi.Their findings suggest that targeting screening to higher-risk areas may offer better cost-effectiveness.

Image credit: cottonbro studio, Pexels

Potential health impacts and costs of active case finding guided by Mycobacterium tuberculosis immunoreactivity survey results in Blantyre, Malawi: A mathematical modeling study

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Browse Issues 2004 – 2026

10/06/2026

Research Article

A machine learning-derived aging index for risk stratification and mortality prediction in cardiovascular-kidney-metabolic syndrome: A retrospective cohort study

In this cohort study, Zhengyang Zhu and colleagues develop a machine learning-derived cardiovascular-kidney-metabolic aging index that outperformed established biological age measures in identifying high-risk CKM profiles and predicting mortality, while revealing distinct aging-metabolic phenotypes that may inform risk stratification and prevention efforts.

Image credit: stevepb, Pixabay

A machine learning-derived aging index for risk stratification and mortality prediction in cardiovascular-kidney-metabolic syndrome: A retrospective cohort study

09/30/2026

Research Article

The association between disability and mortality among children and adolescents: A systematic review and meta-analysis

In this systematic review and meta-analysis, Maureen Moyo-Chilufya and colleagues synthesize evidence from more than 35 million children and adolescents to examine differences in all-cause mortality by disability status. The study finds that children and adolescents with disabilities experienced higher mortality rates than their non-disabled peers.

Image credit: Ivan S, Pexels

The association between disability and mortality among children and adolescents: A systematic review and meta-analysis

09/29/2026

Research Article

Assessing a multicomponent quality improvement strategy for chronic care of cardiovascular diseases in India: The C-QIP randomized feasibility trial

Kavita Singh and colleagues evaluated a multicomponent quality improvement strategy for chronic cardiovascular disease care in India and found it was feasible to implement, well accepted by patients and providers, and delivered with high fidelity across diverse settings.

Image credit: Tima Miroshnichenko, Pexels

09/29/2026

Research Article

Prenatal exposure to maternal depression and antidepressants and neurodevelopmental outcomes: A population cohort study

In this study of more than 167,000 children in Wales, Saraid McIlvride and colleagues examine how prenatal exposure to maternal depression and antidepressants relates to later neurodevelopmental outcomes.

Image credit: Andressa Chagas, Pexels

09/23/2026

Research Article

Evaluation of the tuberculosis notification impact from an intermediary-facilitated public–private mix intervention in Viet Nam: A population-level quasi-experimental study

Luan Nguyen Quang Vo and colleagues assess the effects of a public-private mix intervention implemented in Viet Nam designed to increase tuberculosis notifications from private healthcare providers.

Image credit: Rogan Yeoh, Unsplash

09/22/2026

Research Article

Global, regional, and national impact of epidemic disasters on health workforce equality between 1990 and 2019: An ecological and modeling study

Manman Chen, Wanzhou Wang and colleagues examine how infectious disease epidemics associate with changes in the health workforce.

Image credit: Mikhail Nilov, Pexels

09/28/2026

Editorial

From wrist to research: Harnessing smartwatch data for equitable cardiovascular research

In this Editorial, Manpreet Kaur discusses the opportunity for and challenges to harnessing cardiovascular data from smartwatches.

Image credit: Nik, Unsplash

09/24/2026

Research Article

Encampment sweeps and persistent homelessness among unhoused people who use drugs in Vancouver, Canada: A prospective cohort study

By Kanna Hayashi and colleagues.

Image credit: Francesco Fagioli, Pexels

09/16/2026

Research Article

The retail food environment following a mandatory healthy checkout policy: A natural experimental evaluation

By Jennifer Falbe and colleagues.

Image credit: JEaLiFe Pictures, Unsplash

Bacterial Antimicrobial Resistance

Antimicrobial Resistance: Addressing a Global Threat to Humanity

In this Editorial, Guest Editors Timothy R. Walsh, Ana C. Gales, Ramanan Laxminarayan, and our PLOS Medicine Editor Philippa C. Dodd discuss the Special Issue dedicated to Antimicrobial resistance and emphasize the urgent threat of antimicrobial resistance.
Global incidence in hospital-associated infections resistant to antibiotics: An analysis of point prevalence surveys from 99 countries

Ruchita Balasubramanian and colleagues, estimate the incidence of hospital-associated infections resistant to antibiotics in 195 countries using point prevalence survey data.
Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)

James Neal Russell and colleagues explore antibiotic use and mortality prediction in hospitalised neonates and infants with sepsis.
Antimicrobial resistance: Strengthening surveillance for public health action

Silvia Bertagnolio, Amitabh Bipin Suthar, Olga Tosas and Kitty Van Weezenbeek discuss surveillance of antimicrobial resistance, the existing limitations and the implications this has on accurate determination of incidence.

PLOS Medicine Collections

COVID-19 Pandemic and Global Mental Health

In this Special Issue, we present a fascinating array of research papers providing insights into various facets of mental health during the pandemic.
Bacterial Antimicrobial Resistance: Surveillance and Prevention

This collection of research articles highlights the multi-faceted challenges imposed by drug-resistant bacteria, the consequences for health and economics, and interventions that could lessen the burden.
Early Detection and Minimal Residual Disease

In this Collection, PLOS Medicine presents high-quality translational research and clinical studies on advances in early cancer detection.
Global Child Health: From Birth to Adolescence and Beyond

This Special Issue brings together the latest research on child and adolescent health, including strategies to monitor and combat child mortality from birth through adolescence, and environmental impacts on child health and mortality.
Maternal and Child Health & Nutrition

This 2019 Special Issue highlights the importance of nutrition for maternal and child health.

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