May 20, 2026

Brain morphology in Anorexia Nervosa and its subtypes: A multi-cohort study of individual participant data

In a multi-cohort study, Bernardoni and colleagues investigate potential brain structure differences between patients with Anorexia Nervosa (AN), and AN patients versus healthy controls, using individual participant data.

Image credit: Bernardoni and colleagues

05/29/2026

Perspective

Availability, appeal, and addictiveness by design: Tobacco and nicotine industry deliberate targeting of youth

In recognition of the World No Tobacco Day 2026 theme, "unmasking the appeal", this Perspective by Emily Banks and colleagues discusses how tobacco and nicotine products, particularly e-cigarettes, are deliberately designed and marketed to maximize youth appeal, and highlight the need for policies to ensure greater industry accountability and to tackle concerning uptake trends.

Image credit: Paul Bill, Unsplash

Availability, appeal, and addictiveness by design: Tobacco and nicotine industry deliberate targeting of youth

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Browse Issues 2004 – 2026

05/29/2026

Research Article

Characterization of the VHH-Fc construct rimteravimab in healthy adults and patients hospitalized for mild-to-moderate COVID-19: Two Phase 1 randomized clinical trials

In two phase 1 clinical trials, Ellen Jansen and colleagues evaluate the safety of a humanized antibody consisting of two camelid-derived VHH antibody domains targeting the spike protein of SARS-CoV-2.

Image credit: Fusion Medical Animation, Unsplash

Characterization of the VHH-Fc construct rimteravimab in healthy adults and patients hospitalized for mild-to-moderate COVID-19: Two Phase 1 randomized clinical trials

05/27/2026

Research Article

Sequential chemo-immunotherapy followed by standard versus reduced thoracic radiotherapy for older and/or frail stage III non-small-cell lung cancer: A randomized open-label cohort trial

In a randomized open-label trial, Wei-Xiang Qi and colleagues investigate the feasibility of dose-reduced thoracic radiotherapy to mitigate treatment related toxicities while preserving oncological outcomes in older patients with Stage III Non-small-cell Lung Cancer.

Image credit: Craig Cameron, Unsplash

Sequential chemo-immunotherapy followed by standard versus reduced thoracic radiotherapy for older and/or frail stage III non-small-cell lung cancer: A randomized open-label cohort trial

05/21/2026

Perspective

Novel symptoms associated with eclampsia could improve detection and save lives

Eclampsia is a life-threatening complication of pre-eclampsia, yet remains difficult to predict. In this Perspective, Alice Beardmore-Gray and Andrew Shennan highlight a recent study that identifies 10 novel prodromal symptoms of eclampsia, with potential to better predict which women are at risk and therefore reduce delays in intervention.

Image credit: Max Böhme, Unsplash

05/21/2026

Research Article

Semaglutide-associated risk of nonarteritic anterior ischemic optic neuropathy in patients with type 2 diabetes: A systematic review and meta-analysis of observational studies

In a systematic review and meta-analysis of observational studies, Jędrzej Chrzanowski and colleagues investigate whether there is an association between semaglutide use and the development of non-arteritic anterior ischemic optic neuropathy (NAION).

Image credit: Maria Eduarda Godoi, Pexels

05/20/2026

Research Article

Prescribed hormonal contraceptive use trends in the Estonian Biobank: A longitudinal observational study

In this longitudinal descriptive study, Laisk and colleagues investigate the suitability of the Estonian Biobank for studying the genetic risk of hormonal contraceptive (HC) side effects. They also describe HC use trends, based on prescriptions and purchases, and compare these with data from the Estonian population.

Image credit: Tima Miroshnichenko, Pexels

05/20/2026

Research Article

Associations between hematologic dynamics during pregnancy and obstetric complications: A retrospective observational study

By Veronica Tozzo, Rachel Petherbridge and colleagues.

Image credit: www.kaboompics.com, Pexels

05/13/2026

Research Article

Contribution of nosocomial transmission to Klebsiella pneumoniae neonatal sepsis in Africa and South Asia: An observational study of infection clusters inferred from pathogen genomics and temporal data

By Erkison Odih and colleagues.

Image credit: Joshua Taylor, Unsplash

05/14/2026

Research Article

Antibody fine specificity correlates with protection from malaria for the RTS,S vaccine in young African children: A post hoc analysis of a phase IIb randomised controlled trial

By Alessia Hysa and colleagues.

Image credit: Anirudh, Unsplash

05/21/2026

Perspective

U = U for all: Advancing equity in HIV prevention

In this Perspective, Thiago Torres & Paula Luz outline what is needed to improve equity and accuracy in awareness and education of the Undetectable = Untransmittable (U=U) messaging for HIV.

Image credit: Bermix Studio, Unsplash

Bacterial Antimicrobial Resistance

Antimicrobial Resistance: Addressing a Global Threat to Humanity

In this Editorial, Guest Editors Timothy R. Walsh, Ana C. Gales, Ramanan Laxminarayan, and our PLOS Medicine Editor Philippa C. Dodd discuss the Special Issue dedicated to Antimicrobial resistance and emphasize the urgent threat of AMR.
Global incidence in hospital-associated infections resistant to antibiotics: An analysis of point prevalence surveys from 99 countries

Ruchita Balasubramanian and colleagues, estimate the incidence of hospital-associated infections resistant to antibiotics in 195 countries using point prevalence survey data.
Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)

James Neal Russell and colleagues explore antibiotic use and mortality prediction in hospitalised neonates and infants with sepsis.
Antimicrobial resistance: Strengthening surveillance for public health action

Silvia Bertagnolio, Amitabh Bipin Suthar, Olga Tosas and Kitty Van Weezenbeek discuss surveillance of antimicrobial resistance, the existing limitations and the implications this has on accurate determination of incidence.

PLOS Medicine Collections

COVID-19 Pandemic and Global Mental Health

In this Special Issue, we present a fascinating array of research papers providing insights into various facets of mental health during the pandemic.
Bacterial Antimicrobial Resistance: Surveillance and Prevention

This collection of research articles highlights the multi-faceted challenges imposed by drug-resistant bacteria, the consequences for health and economics, and interventions that could lessen the burden.
Early Detection and Minimal Residual Disease

In this Collection, PLOS Medicine presents high-quality translational research and clinical studies on advances in early cancer detection.
Global Child Health: From Birth to Adolescence and Beyond

This Special Issue brings together the latest research on child and adolescent health, including strategies to monitor and combat child mortality from birth through adolescence, and environmental impacts on child health and mortality.
Maternal and Child Health & Nutrition

This 2019 Special Issue highlights the importance of nutrition for maternal and child health.

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