March 26, 2025

A catalyst for better

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06/05/2025

Research Article

Community health worker–facilitated telehealth for moderate–severe hypertension care in Kenya and Uganda: A randomized controlled trial

In a pilot RCT, Matthew D. Hickey and colleagues investigate whether community-based hypertension treatment, delivered through community health worker home visits and supervised by a clinician via telehealth, improves hypertension control more effectively than primary care clinic-based treatment in rural Uganda and Kenya.

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Community health worker–facilitated telehealth for moderate–severe hypertension care in Kenya and Uganda: A randomized controlled trial

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Browse Issues 2004 – 2025

06/17/2025

Research Article

Vaccination strategies, public health impact and cost-effectiveness of dengue vaccine TAK-003: A modelling case study in Thailand

In a case study of Thailand, modeling vaccination with the TAK-003 dengue vaccine can help optimize strategies to reduce health and economic burdens of dengue disease.

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Vaccination strategies, public health impact and cost-effectiveness of dengue vaccine TAK-003: A modelling case study in Thailand

06/16/2025

Perspective

Making social sciences foundational to academic medicine

In this Perspective, Sahar Sadjadi and colleagues discuss the imperative for incorporating social sciences into medical research, education and implementation.

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Making social sciences foundational to academic medicine

05/20/2025

Research Article

Alcohol intake and pancreatic cancer risk: An analysis from 30 prospective studies across Asia, Australia, Europe, and North America

Sabine Naudin and colleagues leverage individual-level data from 30 prospective cohorts from four continents to examine the association between alcohol intake and pancreatic cancer risk.

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05/22/2025

Perspective

Power in numbers: Harnessing global data to unravel the alcohol-pancreatic cancer link

In this Perspective, Gilaad G. Kaplan discusses the power of harmonizing global data to investigate associations between alcohol consumption and pancreatic cancer risk.

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05/13/2025

Research Article

Safety and tolerability of intravenous liposomal GM1 in patients with Parkinson disease: A single-center open-label clinical phase I trial (NEON trial)

In this phase 1b study reported by Stefan Halbherr and colleagues, a liposomal formulation of GM1 was assessed in 12 patients with Parkinson disease.

Image credit: Anna Shvets, pexels

05/28/2025

Research Article

Twenty-year outcomes after repeat doses of antenatal corticosteroids prior to 32 weeks’ gestation: Follow-up of a randomised clinical trial

Robyn W. May and team examine if repeat doses of antenatal corticosteroids given before 32 weeks' gestation affect health in offspring during adulthood.

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05/08/2025

Research Article

Cost-effectiveness of screening with transcriptional signatures for incipient TB among U.S. migrants

Yuli Lily Hsieh and colleagues evaluate the health impact and cost-effectiveness of using host-response transcriptional signatures to screen new migrants in the U.S. for tuberculosis after arrival.

Image credit: CDC, unsplash

06/02/2025

Research Article

Association of initiating CYP2D6-metabolized opioids with risks of adverse outcomes in older adults receiving antidepressants: A retrospective cohort study

Yu-Jung Jenny Wei and colleagues examine the association of initiating treatment with CYP2D6-metabolized opioids with adverse outcomes.

Image credit: Roberto Sorin, unsplash

05/29/2025

Research Article

Assessment of lung function and severity grading in interstitial lung diseases (% predicted versus z-scores) and association with survival: A retrospective cohort study of 6,808 patients

Piotr W. Boros and team assess which lung function measure better predicts mortality in ILD.

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Bacterial Antimicrobial Resistance

Antimicrobial Resistance: Addressing a Global Threat to Humanity

In this Editorial, Guest Editors Timothy R. Walsh, Ana C. Gales, Ramanan Laxminarayan, and our PLOS Medicine Editor Philippa C. Dodd discuss the Special Issue dedicated to Antimicrobial resistance and emphasize the urgent threat of AMR.
Global incidence in hospital-associated infections resistant to antibiotics: An analysis of point prevalence surveys from 99 countries

Ruchita Balasubramanian and colleagues, estimate the incidence of hospital-associated infections resistant to antibiotics in 195 countries using point prevalence survey data.
Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)

James Neal Russell and colleagues explore antibiotic use and mortality prediction in hospitalised neonates and infants with sepsis.
Antimicrobial resistance: Strengthening surveillance for public health action

Silvia Bertagnolio, Amitabh Bipin Suthar, Olga Tosas and Kitty Van Weezenbeek discuss surveillance of antimicrobial resistance, the existing limitations and the implications this has on accurate determination of incidence.
Implications of reducing antibiotic treatment duration for antimicrobial resistance in hospital settings: A modelling study and meta-analysis

Yin Mo and colleagues investigate implications of antibiotic duration on antibiotic resistance in hospitals.

PLOS Medicine Collections

COVID-19 Pandemic and Global Mental Health

In this Special Issue, we present a fascinating array of research papers providing insights into various facets of mental health during the pandemic.
Bacterial Antimicrobial Resistance: Surveillance and Prevention

This collection of research articles highlights the multi-faceted challenges imposed by drug-resistant bacteria, the consequences for health and economics, and interventions that could lessen the burden.
Early Detection and Minimal Residual Disease

In this Collection, PLOS Medicine presents high-quality translational research and clinical studies on advances in early cancer detection.
Global Child Health: From Birth to Adolescence and Beyond

This Special Issue brings together the latest research on child and adolescent health, including strategies to monitor and combat child mortality from birth through adolescence, and environmental impacts on child health and mortality.
Maternal and Child Health & Nutrition

This 2019 Special Issue highlights the importance of nutrition for maternal and child health.

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