November 18, 2025
Image credit: Anna Shvets, Pexels
11/05/2025
Research Article
In this modelling study, Lisanne van Prooyen Schuurman and colleagues compare the clinical and economic impact of different prenatal testing methods.
Image credit: Natalie Bond, Pexels
Browse Issues 2004 – 2025
11/18/2025
Research Article
Using data from 22 prospective cohort studies, Erfan Nmn Tasdighi and colleagues investigate the relationships among smoking burden, intensity, and cessation duration across multiple cardiovascular outcomes.
Image credit: Stefan Schweihofer, Pixabay
10/31/2025
Editorial
The TARGET guidelines aim to improve transparency and consistency in reporting of observational studies that emulate target trials. This Editorial announces that PLOS Medicine fully endorses the TARGET guidelines and asks that new submissions of target trial emulation studies adhere to them.
Image credit: Mikhail Nilov, Pexels
11/04/2025
Research Article
Naomi R Waterlow and colleagues estimate the future AMR burden in Europe, investigating resistance variation by age, sex and the impact of interventions to achieve the proposed UN political declaration targets.
Image credit: CDC, Unsplash
11/06/2025
Perspective
Pertinent to recent international health aid cuts, this Perspective discusses how middle-income countries can prepare and succeed in transitioning away from external aid, highlighting 3 important factors: Effective leadership, using domestic resources to close the funding gap, and realigning country systems to new sources of domestic funding.
Image credit: Valentin Antonucci, Pexels
11/03/2025
Research Article
In a randomized controlled trial, Charlotte van Dijk and colleagues compare the effects of a cervical pessary and vaginal progesterone on preventing adverse perinatal outcomes in women with multiple pregnancies.
Image credit: Jonathan Borba, Pexels
10/31/2025
Perspective
This Perspective highlights the need for adjusted thresholds and better echocardiography access for NT-proBNP to remain as a high negative predictive value rule-out test in primary care.
Image credit: Tara Winstead, Pexels
10/15/2025
Research Article
Andrew E. Walker and colleagues examine proximity and consistency as spatial metrics of CD8+ T cells within the breast cancer immune microenvironment.
Image credit: pmed.1004647
10/21/2025
Research Article
By Mengping Zhou and colleagues.
Image credit: Unsplash, Michael Coltman
10/30/2025
Research Article
By Nicholas R. Jones and colleagues.
Image credit: Unsplash, Robina Weermeijer
In this Editorial, Guest Editors Timothy R. Walsh, Ana C. Gales, Ramanan Laxminarayan, and our PLOS Medicine Editor Philippa C. Dodd discuss the Special Issue dedicated to Antimicrobial resistance and emphasize the urgent threat of AMR.
Ruchita Balasubramanian and colleagues, estimate the incidence of hospital-associated infections resistant to antibiotics in 195 countries using point prevalence survey data.
James Neal Russell and colleagues explore antibiotic use and mortality prediction in hospitalised neonates and infants with sepsis.
Silvia Bertagnolio, Amitabh Bipin Suthar, Olga Tosas and Kitty Van Weezenbeek discuss surveillance of antimicrobial resistance, the existing limitations and the implications this has on accurate determination of incidence.
Yin Mo and colleagues investigate implications of antibiotic duration on antibiotic resistance in hospitals.
In this Special Issue, we present a fascinating array of research papers providing insights into various facets of mental health during the pandemic.
This collection of research articles highlights the multi-faceted challenges imposed by drug-resistant bacteria, the consequences for health and economics, and interventions that could lessen the burden.
In this Collection, PLOS Medicine presents high-quality translational research and clinical studies on advances in early cancer detection.
This Special Issue brings together the latest research on child and adolescent health, including strategies to monitor and combat child mortality from birth through adolescence, and environmental impacts on child health and mortality.
This 2019 Special Issue highlights the importance of nutrition for maternal and child health.
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