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Effect of a digital intervention on mental health symptoms in adults with chronic conditions: A three-arm randomized controlled trial

August 20, 2026

Effect of a digital intervention on mental health symptoms in adults with chronic conditions: A three-arm randomized controlled trial


In a remotely conducted, randomized clinical trial with participants spanning 13 countries, Emily Johnson and colleagues find that a multicomponent digital intervention coupled with human support can reduce anxiety and depression in persons with chronic conditions.

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08/12/2026

Research Article

Long-term risk of cardiovascular disease after assisted reproductive technology and infertility: A cohort study

In this nationwide Swedish cohort study, Angelo Mezzoiuso and colleagues found that assisted reproductive technology was not associated with higher long-term risk for most cardiovascular conditions. The findings also suggest that infertility may be linked with elevated long-term cardiometabolic risks, supporting its role as a potential marker of future health risk.

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Long-term risk of cardiovascular disease after assisted reproductive technology and infertility: A cohort study

08/24/2026

Research Article

Trends of stillbirth, early neonatal and perinatal mortality rates and sociodemographic differentials of perinatal mortality rates in 17 low- and middle-income countries: A modeling study

Using data from demographic surveys, Mohamed Ali and colleagues applied statistical adjustments to improve estimates of stillbirth, early neonatal, and perinatal mortality trends for 17 low- and middle-income countries. Their analysis suggests that mortality rates have generally declined since 1990, but progress has varied across countries.

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Trends of stillbirth, early neonatal and perinatal mortality rates and sociodemographic differentials of perinatal mortality rates in 17 low- and middle-income countries: A modeling study

08/18/2026

Editorial

World Humanitarian Day: Why humanitarian settings need more research, not less

In this Editorial, Akihiro Seita outlines how and why medical journals should recognize that while conventional study designs are often not possible in humanitarian settings, this does not undermine the quality or rigor of such research, and outlines why it deserves greater support and recognition.

World Humanitarian Day: Why humanitarian settings need more research, not less

Image credit: Jon Tyson, Unsplash

08/17/2026

Research Article

Avoidable mortality, clinical outcomes and determinants of premature death among adults with severe or profound intellectual disability: A population-based analysis of mortality data in England

In a population-based analysis, Michael Kwan Leung and colleagues report that adults with severe or profound intellectual disability have a markedly higher rate of avoidable death due to preventable or treatable causes than adults with moderate intellectual disability.

Avoidable mortality, clinical outcomes and determinants of premature death among adults with severe or profound intellectual disability: A population-based analysis of mortality data in England

Image credit: Anita Austvika, Unsplash

08/17/2026

Research Article

Effectiveness of a scalable, remotely delivered stepped-care intervention for psychological distress among Polish migrant workers in the Netherlands: The RESPOND randomised controlled trial

In a randomised controlled trial of a remotely-delivered intervention, Rinske Roos and colleagues report that guided online self-help followed by psychological support by video-conferencing reduced symptoms of anxiety and depression in migrant workers.

Effectiveness of a scalable, remotely delivered stepped-care intervention for psychological distress among Polish migrant workers in the Netherlands: The RESPOND randomised controlled trial

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PLOS Medicine | ISSN: 1549-1676 (online)