September 23, 2026

The effect of lifestyle interventions in women with polyendocrine metabolic ovarian syndrome: A systematic review and meta-analysis

In a systematic review and meta-analysis, Oladipupo Olalere and colleagues find that lifestyle interventions in women with polyendocrine metabolic ovarian syndrome are associated with improved menstrual regularity, reduced waist circumference, and lower fasting glucose and insulin levels.

Image credit: Maurice Engelen, Pexels

09/23/2026

Research Article

Evaluation of the tuberculosis notification impact from an intermediary-facilitated public–private mix intervention in Viet Nam: A population-level quasi-experimental study

Using a population-level quasi-experimental study design, Luan Nguyen Quang Vo and colleagues assess the effects of a public-private mix intervention implemented in Viet Nam designed to increase tuberculosis notifications, with the aim that such approaches could ultimately increase treatment coverage.

Image credit: Rogan Yeoh, Unsplash

Evaluation of the tuberculosis notification impact from an intermediary-facilitated public–private mix intervention in Viet Nam: A population-level quasi-experimental study

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Browse Issues 2004 – 2026

09/22/2026

Research Article

Global, regional, and national impact of epidemic disasters on health workforce equality between 1990 and 2019: An ecological and modeling study

Chen, Wang and colleagues examined how infectious disease epidemics were associated with changes in the health workforce across 194 countries and territories from 1990 to 2019. Their findings suggest that epidemic events were linked to health workforce losses worldwide, with the largest relative impacts observed in low- and middle-income countries.

Image credit: Mikhail Nilov, Pexels

Global, regional, and national impact of epidemic disasters on health workforce equality between 1990 and 2019: An ecological and modeling study

09/28/2026

Editorial

From wrist to research: Harnessing smartwatch data for equitable cardiovascular research

Cardiovascular disease is a leading cause of death, and progress in reducing mortality has been established, calling for more research. In this Editorial, Manpreet Kaur discusses the opportunity for harnessing cardiovascular data from smartwatches, and the ethical and logistical barriers to ensuring smartwatch-derived data informs equitable and actionable cardiovascular research.

Image credit: Nik, Unsplash

From wrist to research: Harnessing smartwatch data for equitable cardiovascular research

09/24/2026

Research Article

Encampment sweeps and persistent homelessness among unhoused people who use drugs in Vancouver, Canada: A prospective cohort study

Kanna Hayashi and colleagues examine the effect of encampment sweeps, including the confiscation of personal belongings and forced displacement, in Vancouver, Canada. Their findings highlight concerns that such practices may hinder pathways to stable housing.

Image credit: Francesco Fagioli, Pexels

09/16/2026

Research Article

The retail food environment following a mandatory healthy checkout policy: A natural experimental evaluation

In this natural experiment study, Jennifer Falbe and colleagues show that the mandatory healthy checkout policy in Perris, California, is associated with a notable increase in healthier food and beverage products displayed near cash registers, where the policy applies.

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09/17/2026

Research Article

Blood test trend versus single threshold abnormality to discriminate cancer from non-cancer in patients with unexpected weight loss: A retrospective cohort study

In this retrospective cohort study, Brian D. Nicholson and colleagues evaluate the potential of blood test trends in comparison to blood test abnormalities for cancer risk assessment in patients with non-specific symptoms, such as weight loss.

Image credit: National Cancer Institute, Unsplash

09/18/2026

Perspective

Living with a rare disease: Why lived experience must shape research

Gemma Whyatt and Jodi Whitehouse outline why lived experience must shape rare disease research from the outset, and discuss how genuine patient-researcher partnership transforms science, care and identity.

Image credit: photographer Brock Elbank.

09/01/2026

Research Article

Evaluation of the FI-Lab, a laboratory-based, automated frailty index for acute care: A multicohort study

In this multicohort study, Hugh Logan Ellis and colleagues optimize the laboratory-based frailty index for use as a general measure of illness severity across all adults and different healthcare settings.

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09/15/2026

Research Article

Predicting resistance to fluoroquinolones among patients with rifampicin-resistant tuberculosis: A cross-country validation study

In this study, Shao and colleagues evaluate whether routinely available patient characteristics can help predict fluoroquinolone resistance.

Image credit: CDC, Unsplash

09/16/2026

Policy Forum

HIV self-testing and the global diagnostic gap: Addressing a decade of missed opportunity

Isabelle Munyangaju and colleagues discuss why the roll-out and scale-up of HIV self-testing over the last decade has been inadequate, and highlight what is needed to close the diagnostic gap.

Image credit: Akram Huseyn, Unsplash

Bacterial Antimicrobial Resistance

Antimicrobial Resistance: Addressing a Global Threat to Humanity

In this Editorial, Guest Editors Timothy R. Walsh, Ana C. Gales, Ramanan Laxminarayan, and our PLOS Medicine Editor Philippa C. Dodd discuss the Special Issue dedicated to Antimicrobial resistance and emphasize the urgent threat of antimicrobial resistance.
Global incidence in hospital-associated infections resistant to antibiotics: An analysis of point prevalence surveys from 99 countries

Ruchita Balasubramanian and colleagues, estimate the incidence of hospital-associated infections resistant to antibiotics in 195 countries using point prevalence survey data.
Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)

James Neal Russell and colleagues explore antibiotic use and mortality prediction in hospitalised neonates and infants with sepsis.
Antimicrobial resistance: Strengthening surveillance for public health action

Silvia Bertagnolio, Amitabh Bipin Suthar, Olga Tosas and Kitty Van Weezenbeek discuss surveillance of antimicrobial resistance, the existing limitations and the implications this has on accurate determination of incidence.

PLOS Medicine Collections

COVID-19 Pandemic and Global Mental Health

In this Special Issue, we present a fascinating array of research papers providing insights into various facets of mental health during the pandemic.
Bacterial Antimicrobial Resistance: Surveillance and Prevention

This collection of research articles highlights the multi-faceted challenges imposed by drug-resistant bacteria, the consequences for health and economics, and interventions that could lessen the burden.
Early Detection and Minimal Residual Disease

In this Collection, PLOS Medicine presents high-quality translational research and clinical studies on advances in early cancer detection.
Global Child Health: From Birth to Adolescence and Beyond

This Special Issue brings together the latest research on child and adolescent health, including strategies to monitor and combat child mortality from birth through adolescence, and environmental impacts on child health and mortality.
Maternal and Child Health & Nutrition

This 2019 Special Issue highlights the importance of nutrition for maternal and child health.

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