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Table of Contents

March 2018

Tumor-associated calcium signal transducer (TACSTD2), one of the most down-regulated genes in hepatocellular carcinoma tissue, regulates the cellular localization of claudin-1 (CLDN1) and occludin (OCLN), two tight-junction proteins that mediate HCV entry into hepatocytes. TACSTD2 gene silencing (right panels) disrupts the typical linear distribution of both CLDN1 (red, upper left) and OCLN (red, lower left) along the cellular membrane of primary human hepatocytes. TACSTD2 gene silencing dramatically inhibits HCV infection with a pan-genotype effect. Farci et al. (2018)

Image Credit: Vandana Sekhar, Juraj Kabat and Patrizia Farci; Laboratory of Infectious Diseases and Biological Imaging Facility, NIAID, NIH

Editorials

Pearls collections: What we can learn about infectious disease and cancer

Laura J. Knoll, Deborah A. Hogan, John M. Leong, Joseph Heitman, Richard C. Condit

Opinion

Pearls

Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases

Anthony K. L. Leung, Robert Lyle McPherson, Diane E. Griffin

Mitogen-activated protein kinase signaling in plant pathogenic fungi

Cong Jiang, Xue Zhang, Huiquan Liu, Jin-Rong Xu

Wicked: The untold story of ciprofloxacin

Zachary C. Conley, Truston J. Bodine, Andrew Chou, Lynn Zechiedrich

Review

Viral manipulation of STAT3: Evade, exploit, and injure

Armando Andres Roca Suarez, Nicolaas Van Renne, Thomas F. Baumert, Joachim Lupberger

Research Matters

The quest for good explanations

Benhur Lee

Research Articles

The bacterial type III-secreted protein AvrRps4 is a bipartite effector

Morgan K. Halane, Sang Hee Kim, Benjamin J. Spears, Christopher M. Garner, Conner J. Rogan, Elizabeth C. Okafor, Jianbin Su, Saikat Bhattacharjee, Walter Gassmann

Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis

Pankaj Deo, Seong H. Chow, Iain D. Hay, Oded Kleifeld, Adam Costin, Kirstin D. Elgass, Jhih-Hang Jiang, Georg Ramm, Kipros Gabriel, Gordon Dougan, Trevor Lithgow, Eva Heinz, Thomas Naderer

Molecularly barcoded Zika virus libraries to probe in vivo evolutionary dynamics

Matthew T. Aliota, Dawn M. Dudley, Christina M. Newman, James Weger-Lucarelli, Laurel M. Stewart, Michelle R. Koenig, Meghan E. Breitbach, Andrea M. Weiler, Matthew R. Semler, Gabrielle L. Barry, Katie R. Zarbock, Amelia K. Haj, Ryan V. Moriarty, Mariel S. Mohns, Emma L. Mohr, Vanessa Venturi, Nancy Schultz-Darken, Eric Peterson, Wendy Newton, Michele L. Schotzko, Heather A. Simmons, Andres Mejia, Jennifer M. Hayes, Saverio Capuano III, Miles P. Davenport, Thomas C. Friedrich, Gregory D. Ebel, Shelby L. O’Connor, David H. O’Connor

Streptococcal M protein promotes IL-10 production by cGAS-independent activation of the STING signaling pathway

Elin Movert, Julia Lienard, Christine Valfridsson, Therése Nordström, Bengt Johansson-Lindbom, Fredric Carlsson

HSV-1-induced disruption of transcription termination resembles a cellular stress response but selectively increases chromatin accessibility downstream of genes

Thomas Hennig, Marco Michalski, Andrzej J. Rutkowski, Lara Djakovic, Adam W. Whisnant, Marie-Sophie Friedl, Bhaskar Anand Jha, Marisa A. P. Baptista, Anne L’Hernault, Florian Erhard, Lars Dölken, Caroline C. Friedel

miR-126-5p by direct targeting of JNK-interacting protein-2 (JIP-2) plays a key role in Theileria-infected macrophage virulence

Malak Haidar, Zineb Rchiad, Hifzur Rahman Ansari, Fathia Ben-Rached, Shahin Tajeri, Perle Latre De Late, Gordon Langsley, Arnab Pain

PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice

Eléonore Pérès, Juliana Blin, Emiliano P. Ricci, Maria Artesi, Vincent Hahaut, Anne Van den Broeke, Antoine Corbin, Louis Gazzolo, Lee Ratner, Pierre Jalinot, Madeleine Duc Dodon

A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development

Tiffany Bouchery, Kara Filbey, Amy Shepherd, Jodie Chandler, Deepa Patel, Alfonso Schmidt, Mali Camberis, Adeline Peignier, Adam A. T. Smith, Karen Johnston, Gavin Painter, Mark Pearson, Paul Giacomin, Alex Loukas, Maria-Elena Bottazzi, Peter Hotez, Graham LeGros

Down-regulation of microRNA-203-3p initiates type 2 pathology during schistosome infection via elevation of interleukin-33

Xing He, Jun Xie, Yange Wang, Xiaobin Fan, Qin Su, Yue Sun, Nanhang Lei, Dongmei Zhang, Guangping Gao, Weiqing Pan

Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana

Julie Kovářová, Andrew W. Pountain, David Wildridge, Stefan Weidt, Frédéric Bringaud, Richard J. S. Burchmore, Fiona Achcar, Michael P. Barrett

Nuclear RNA surveillance complexes silence HIV-1 transcription

Xavier Contreras, Kader Salifou, Gabriel Sanchez, Marion Helsmoortel, Emmanuelle Beyne, Lisa Bluy, Stéphane Pelletier, Emilie Rousset, Sylvie Rouquier, Rosemary Kiernan

Evolution of echovirus 11 in a chronically infected immunodeficient patient

Majid Laassri, Tatiana Zagorodnyaya, Sharon Hassin-Baer, Rachel Handsher, Danit Sofer, Merav Weil, Konstantinos Karagiannis, Vahan Simonyan, Konstantin Chumakov, Lester Shulman

Genetic requirements for Staphylococcus aureus nitric oxide resistance and virulence

Melinda R. Grosser, Elyse Paluscio, Lance R. Thurlow, Marcus M. Dillon, Vaughn S. Cooper, Thomas H. Kawula, Anthony R. Richardson

Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia

Joseph D. Turner, Nicolas Pionnier, Julio Furlong-Silva, Hanna Sjoberg, Stephen Cross, Alice Halliday, Ana F. Guimaraes, Darren A. N. Cook, Andrew Steven, Nico Van Rooijen, Judith E. Allen, Stephen J. Jenkins, Mark J. Taylor

The root-knot nematode effector MiPFN3 disrupts plant actin filaments and promotes parasitism

Natthanon Leelarasamee, Lei Zhang, Cynthia Gleason

SpdC, a novel virulence factor, controls histidine kinase activity in Staphylococcus aureus

Olivier Poupel, Caroline Proux, Bernd Jagla, Tarek Msadek, Sarah Dubrac

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

Frances Rocamora, Lei Zhu, Kek Yee Liong, Arjen Dondorp, Olivo Miotto, Sachel Mok, Zbynek Bozdech

Infection with hepatitis C virus depends on TACSTD2, a regulator of claudin-1 and occludin highly downregulated in hepatocellular carcinoma

Vandana Sekhar, Teresa Pollicino, Giacomo Diaz, Ronald E. Engle, Farah Alayli, Marta Melis, Juraj Kabat, Ashley Tice, Anna Pomerenke, Nihal Altan-Bonnet, Fausto Zamboni, Paolo Lusso, Suzanne U. Emerson, Patrizia Farci

Pleiotropic roles of Clostridium difficile sin locus

Brintha Parasumanna Girinathan, Junjun Ou, Bruno Dupuy, Revathi Govind

Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivo

Kaiyi Zhang, Ambre Riba, Monika Nietschke, Natalia Torow, Urska Repnik, Andreas Pütz, Marcus Fulde, Aline Dupont, Michael Hensel, Mathias Hornef

Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor

Nicole Stichling, Maarit Suomalainen, Justin W. Flatt, Markus Schmid, Martin Pacesa, Silvio Hemmi, Wolfgang Jungraithmayr, Mareike D. Maler, Marina A. Freudenberg, Andreas Plückthun, Tobias May, Mario Köster, György Fejer, Urs F. Greber

Inclusion bodies of human parainfluenza virus type 3 inhibit antiviral stress granule formation by shielding viral RNAs

Zhulong Hu, Yuang Wang, Qiaopeng Tang, Xiaodan Yang, Yali Qin, Mingzhou Chen

CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection

Yuemei Dong, Maria L. Simões, Eric Marois, George Dimopoulos

COP1, a negative regulator of photomorphogenesis, positively regulates plant disease resistance via double-stranded RNA binding proteins

Gah-Hyun Lim, Timothy Hoey, Shifeng Zhu, Marion Clavel, Keshun Yu, Duroy Navarre, Aardra Kachroo, Jean-Marc Deragon, Pradeep Kachroo

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies

Harrison G. Jones, Tina Ritschel, Gabriel Pascual, Just P. J. Brakenhoff, Elissa Keogh, Polina Furmanova-Hollenstein, Ellen Lanckacker, Jehangir S. Wadia, Morgan S. A. Gilman, R. Anthony Williamson, Dirk Roymans, Angélique B. van ‘t Wout, Johannes P. Langedijk, Jason S. McLellan

TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

Allison F. Carey, Jeremy M. Rock, Inna V. Krieger, Michael R. Chase, Marta Fernandez-Suarez, Sebastien Gagneux, James C. Sacchettini, Thomas R. Ioerger, Sarah M. Fortune

A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism

Florian Douam, Floriane Fusil, Margot Enguehard, Linda Dib, Francesca Nadalin, Loïc Schwaller, Gabriela Hrebikova, Jimmy Mancip, Laurent Mailly, Roland Montserret, Qiang Ding, Carine Maisse, Emilie Carlot, Ke Xu, Els Verhoeyen, Thomas F. Baumert, Alexander Ploss, Alessandra Carbone, François-Loïc Cosset, Dimitri Lavillette

Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections

Kshitij Wagh, Michael S. Seaman, Marshall Zingg, Tomas Fitzsimons, Dan H. Barouch, Dennis R. Burton, Mark Connors, David D. Ho, John R. Mascola, Michel C. Nussenzweig, Jeffrey Ravetch, Rajeev Gautam, Malcolm A. Martin, David C. Montefiori, Bette Korber

A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function

Avantika S. Chitre, Michael G. Kattah, Yenny Y. Rosli, Montha Pao, Monika Deswal, Steven G. Deeks, Peter W. Hunt, Mohamed Abdel-Mohsen, Luis J. Montaner, Charles C. Kim, Averil Ma, Ma Somsouk, Joseph M. McCune

The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein

Kendra A. Bussey, Ulrike Lau, Sophie Schumann, Antonio Gallo, Lisa Osbelt, Markus Stempel, Christine Arnold, Josef Wissing, Hans Henrik Gad, Rune Hartmann, Wolfram Brune, Lothar Jänsch, Adrian Whitehouse, Melanie M. Brinkmann

Nubbin isoform antagonism governs Drosophila intestinal immune homeostasis

Bo G. Lindberg, Xiongzhuo Tang, Widad Dantoft, Priya Gohel, Shiva Seyedoleslami Esfahani, Jessica M. Lindvall, Ylva Engström

A new cell culture model to genetically dissect the complete human papillomavirus life cycle

Malgorzata Bienkowska-Haba, Wioleta Luszczek, Julia E. Myers, Timothy R. Keiffer, Stephen DiGiuseppe, Paula Polk, Jason M. Bodily, Rona S. Scott, Martin Sapp