Table of Contents

August 2012

Alternatively activated macrophages regulate immune responses in the granulomas around S. mansoni eggs. These cells are an important source of retinoic acid and enhance the differentiation of Foxp3+ T cell differentiation (see Broadhurst et al., doi:10.1371/journal.ppat.1002883). By intravital confocal imaging, autofluorescent eggs are observed in red, hepatocyte nuclei in blue, and CX3CR1+ macrophages in green.

Image Credit: Natasha M. Girgis, New York University Langone Medical Center.


Routine Use of Microbial Whole Genome Sequencing in Diagnostic and Public Health Microbiology

Claudio U. Köser, Matthew J. Ellington, Edward J. P. Cartwright, Stephen H. Gillespie, Nicholas M. Brown, Mark Farrington, Matthew T. G. Holden, Gordon Dougan, Stephen D. Bentley, Julian Parkhill, Sharon J. Peacock


Bacterial Cell Surface Heterogeneity: A Pathogen's Disguise

Henny C. van der Mei, Henk J. Busscher

Fungi and the Rise of Mammals

Arturo Casadevall

Trichomonosis, a Common Curable STI, and Prostate Carcinogenesis—A Proposed Molecular Mechanism

Siobhan Sutcliffe, Calvin Neace, Nancy S. Magnuson, Raymond Reeves, J. F. Alderete

Host Defense and Tolerance: Unique Challenges in the Placenta

Varvara B. Zeldovich, Anna I. Bakardjiev

Phagocyte Responses to Protozoan Infection and How Toxoplasma gondii Meets the Challenge

Eric Y. Denkers, Anne G. Schneider, Sara B. Cohen, Barbara A. Butcher


Invariant NKT Cells: Regulation and Function during Viral Infection

Jennifer A. Juno, Yoav Keynan, Keith R. Fowke

Research Articles

Inhibition of Candida parapsilosis Fatty Acid Synthase (Fas2) Induces Mitochondrial Cell Death in Serum

Long Nam Nguyen, Gabriele Vargas Cesar, Giang Thi Thu Le, David L. Silver, Leonardo Nimrichter, Joshua D. Nosanchuk

Measles Immune Suppression: Lessons from the Macaque Model

Rory D. de Vries, Stephen McQuaid, Geert van Amerongen, Selma Yüksel, R. Joyce Verburgh, Albert D. M. E. Osterhaus, W. Paul Duprex, Rik L. de Swart

Human Monoclonal Antibody HCV1 Effectively Prevents and Treats HCV Infection in Chimpanzees

Trevor J. Morin, Teresa J. Broering, Brett A. Leav, Barbra M. Blair, Kirk J. Rowley, Elisabeth N. Boucher, Yang Wang, Peter S. Cheslock, Michael Knauber, David B. Olsen, Steve W. Ludmerer, Gyongyi Szabo, Robert W. Finberg, Robert H. Purcell, Robert E. Lanford, Donna M. Ambrosino, Deborah C. Molrine, Gregory J. Babcock

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

Amanda J. Price, Adam J. Fletcher, Torsten Schaller, Tom Elliott, KyeongEun Lee, Vineet N. KewalRamani, Jason W. Chin, Greg J. Towers, Leo C. James

Roles of ATM and ATR-Mediated DNA Damage Responses during Lytic BK Polyomavirus Infection

Mengxi Jiang, Linbo Zhao, Monica Gamez, Michael J. Imperiale

Establishment of a Reverse Genetics System for Studying Human Bocavirus in Human Airway Epithelia

Qinfeng Huang, Xuefeng Deng, Ziying Yan, Fang Cheng, Yong Luo, Weiran Shen, Diana C. M. Lei-Butters, Aaron Yun Chen, Yi Li, Liang Tang, Maria Söderlund-Venermo, John F. Engelhardt, Jianming Qiu

Telomere Length Affects the Frequency and Mechanism of Antigenic Variation in Trypanosoma brucei

Galadriel A. Hovel-Miner, Catharine E. Boothroyd, Monica Mugnier, Oliver Dreesen, George A. M. Cross, F. Nina Papavasiliou

Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection

Sara Rodríguez-Martín, Kai Alexander Kropp, Vanessa Wilhelmi, Vanda Juranic Lisnic, Wei Yuan Hsieh, Mathieu Blanc, Andrew Livingston, Andreas Busche, Hille Tekotte, Martin Messerle, Manfred Auer, Iain Fraser, Stipan Jonjic, Ana Angulo, Matthias J. Reddehase, Peter Ghazal

A Novel Virulence Strategy for Pseudomonas aeruginosa Mediated by an Autotransporter with Arginine-Specific Aminopeptidase Activity

Jeni C. A. Luckett, Owen Darch, Chase Watters, Manal AbuOun, Victoria Wright, Esteban Paredes-Osses, Jenny Ward, Hana Goto, Stephan Heeb, Stéphanie Pommier, Kendra P. Rumbaugh, Miguel Cámara, Kim R. Hardie

The Irish Potato Famine Pathogen Phytophthora infestans Translocates the CRN8 Kinase into Host Plant Cells

Mireille van Damme, Tolga O. Bozkurt, Cahid Cakir, Sebastian Schornack, Jan Sklenar, Alexandra M. E. Jones, Sophien Kamoun

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A Unique Bivalent Binding and Inhibition Mechanism by the Yatapoxvirus Interleukin 18 Binding Protein

Brian Krumm, Xiangzhi Meng, Zhixin Wang, Yan Xiang, Junpeng Deng

Elucidation of Hepatitis C Virus Transmission and Early Diversification by Single Genome Sequencing

Hui Li, Mark B. Stoddard, Shuyi Wang, Lily M. Blair, Elena E. Giorgi, Erica H. Parrish, Gerald H. Learn, Peter Hraber, Paul A. Goepfert, Michael S. Saag, Thomas N. Denny, Barton F. Haynes, Beatrice H. Hahn, Ruy M. Ribeiro, Alan S. Perelson, Bette T. Korber, Tanmoy Bhattacharya, George M. Shaw

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Surface α-1,3-Glucan Facilitates Fungal Stealth Infection by Interfering with Innate Immunity in Plants

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Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice

Mara J. Broadhurst, Jacqueline M. Leung, K. C. Lim, Natasha M. Girgis, Uma Mahesh Gundra, Padraic G. Fallon, Mary Premenko-Lanier, James H. McKerrow, Joseph M. McCune, P'ng Loke

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Michael D. Alpert, Jackson D. Harvey, W. Anderson Lauer, R. Keith Reeves, Michael Piatak Jr., Angela Carville, Keith G. Mansfield, Jeffrey D. Lifson, Wenjun Li, Ronald C. Desrosiers, R. Paul Johnson, David T. Evans

CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction

Yoav Peretz, Zhong He, Yu Shi, Bader Yassine-Diab, Jean-Philippe Goulet, Rebeka Bordi, Ali Filali-Mouhim, Jean-Baptiste Loubert, Mohamed El-Far, Franck P. Dupuy, Mohamed Rachid Boulassel, Cécile Tremblay, Jean-Pierre Routy, Nicole Bernard, Robert Balderas, Elias K. Haddad, Rafick-Pierre Sékaly

Asparagine Endopeptidase Controls Anti-Influenza Virus Immune Responses through TLR7 Activation

Sophia Maschalidi, Signe Hässler, Fany Blanc, Fernando E. Sepulveda, Mira Tohme, Michel Chignard, Peter van Endert, Mustapha Si-Tahar, Delphyne Descamps, Bénédicte Manoury

Identification and Targeting of an Interaction between a Tyrosine Motif within Hepatitis C Virus Core Protein and AP2M1 Essential for Viral Assembly

Gregory Neveu, Rina Barouch-Bentov, Amotz Ziv-Av, Doron Gerber, Yves Jacob, Shirit Einav

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging

Luka Cicin-Sain, James D. Brien, Jennifer L. Uhrlaub, Anja Drabig, Thomas F. Marandu, Janko Nikolich-Zugich

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