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Table of Contents

September 2019

As a mitochondrial ABC transporter in Fusarium graminearum, FgAtm1 regulates the activity of cytosolic Fe-S proteins via transporting GSH-linked [2Fe-2S] clusters from mitochondria into cytoplasm. The lack of FgAtm1 reduces the activity of cytosolic Fe-S proteins nitrite reductase and xanthine dehydrogenase, which causes high expression of iron regulator FgHapX via activating the transcription factor FgAreA. FgHapX represses transcription of the genes for iron-consuming proteins, but activates the genes for iron-acquisition proteins. The image indicates that the growth of ΔFgAtm1 is accelerated by feeding with each of the final catalytic products of cytosolic Fe-S proteins. Wang et al.

Image Credit: Z Wang, Y Yin, and Z Ma (2019)

Pearls

Getting in: The structural biology of malaria invasion

Hirdesh Kumar, Niraj H. Tolia

Conidial surface proteins at the interface of fungal infections

Matthew G. Blango, Olaf Kniemeyer, Axel A. Brakhage

Is reliance on an inaccurate genome sequence sabotaging your experiments?

Rodrigo P. Baptista, Jessica C. Kissinger

Emergomyces: The global rise of new dimorphic fungal pathogens

Ilan S. Schwartz, Nelesh P. Govender, Lynne Sigler, Yanping Jiang, Tsidiso G. Maphanga, Barbra Toplis, Alfred Botha, Karolina Dukik, J. Claire Hoving, Jose F. Muñoz, Sybren de Hoog, Christina A. Cuomo, Robert Colebunders, Chris Kenyon

Research Articles

Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage

David Sacks, Jinal N. Bhiman, Kevin Wiehe, Jason Gorman, Peter D. Kwong, Lynn Morris, Penny L. Moore

KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation

Rajnish Kumar Singh, Zachary L. Lamplugh, Fengchao Lang, Yan Yuan, Paul Lieberman, Jianxin You, Erle S. Robertson

Molecular basis for functional diversity among microbial Nep1-like proteins

Tea Lenarčič, Katja Pirc, Vesna Hodnik, Isabell Albert, Jure Borišek, Alessandra Magistrato, Thorsten Nürnberger, Marjetka Podobnik, Gregor Anderluh

The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus

Luiza A. de Castro-Jorge, Renan V. H. de Carvalho, Taline M. Klein, Carlos H. Hiroki, Alexandre H. Lopes, Rafaela M. Guimarães, Marcílio Jorge Fumagalli, Vitor G. Floriano, Mayara R. Agostinho, Renata Dezengrini Slhessarenko, Fernando Silva Ramalho, Thiago M. Cunha, Fernando Q. Cunha, Benedito A. L. da Fonseca, Dario S. Zamboni

Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro

Emily EIM Mouser, Georgios Pollakis, Hermelijn H. Smits, Jordan Thomas, Maria Yazdanbakhsh, Esther C. de Jong, William A. Paxton

HupA, the main undecaprenyl pyrophosphate and phosphatidylglycerol phosphate phosphatase in Helicobacter pylori is essential for colonization of the stomach

Elise Gasiorowski, Rodolphe Auger, Xudong Tian, Samia Hicham, Chantal Ecobichon, Sophie Roure, Martin V. Douglass, M. Stephen Trent, Dominique Mengin-Lecreulx, Thierry Touzé, Ivo Gomperts Boneca

The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion

Emma S. Sherling, Abigail J. Perrin, Ellen Knuepfer, Matthew R. G. Russell, Lucy M. Collinson, Louis H. Miller, Michael J. Blackman

Anti-HIV potency of T-cell responses elicited by dendritic cell therapeutic vaccination

Mathieu Surenaud, Monica Montes, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Jacques Banchereau, Karolina Palucka, Jean-Daniel Lelièvre, Christine Lacabaratz, Yves Lévy

The phage gene wmk is a candidate for male killing by a bacterial endosymbiont

Jessamyn I. Perlmutter, Sarah R. Bordenstein, Robert L. Unckless, Daniel P. LePage, Jason A. Metcalf, Tom Hill, Julien Martinez, Francis M. Jiggins, Seth R. Bordenstein

The opportunistic pathogen Stenotrophomonas maltophilia utilizes a type IV secretion system for interbacterial killing

Ethel Bayer-Santos, William Cenens, Bruno Yasui Matsuyama, Gabriel Umaji Oka, Giancarlo Di Sessa, Izabel Del Valle Mininel, Tiago Lubiana Alves, Chuck Shaker Farah

The molecular clock of Mycobacterium tuberculosis

Fabrizio Menardo, Sebastian Duchêne, Daniela Brites, Sebastien Gagneux

Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival

Liang Wei Wang, Zhonghao Wang, Ina Ersing, Luis Nobre, Rui Guo, Sizun Jiang, Stephen Trudeau, Bo Zhao, Michael P. Weekes, Benjamin E. Gewurz

The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis

Camilla Jensen, Kristoffer T. Bæk, Clement Gallay, Ida Thalsø-Madsen, Lijuan Xu, Ambre Jousselin, Fernando Ruiz Torrubia, Wilhelm Paulander, Ana R. Pereira, Jan-Willem Veening, Mariana G. Pinho, Dorte Frees

RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection

Jae Seung Lee, Keisuke Tabata, Woan-Ing Twu, Md Shafiqur Rahman, Hee Sun Kim, Jin Bae Yu, Min Hyeok Jee, Ralf Bartenschlager, Sung Key Jang

Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge

Xiaoyan Zheng, Jennifer D. Oduro, Julia D. Boehme, Lisa Borkner, Thomas Ebensen, Ulrike Heise, Marcus Gereke, Marina C. Pils, Astrid Krmpotic, Carlos A. Guzmán, Dunja Bruder, Luka Čičin-Šain

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

Celia C. LaBranche, Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, Kevin O. Saunders, S. Munir Alam, Mattia Bonsignori, Mario J. Borgnia, Quentin J. Sattentau, Amanda Eaton, Kelli Greene, Hongmei Gao, Hua-Xin Liao, Wilton B. Williams, James Peacock, Haili Tang, Lautaro G. Perez, Robert J. Edwards, Thomas B. Kepler, Bette T. Korber, Peter D. Kwong, John R. Mascola, Priyamvada Acharya, Barton F. Haynes, David C. Montefiori

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An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

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Correction

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