September 2019

As a mitochondrial ABC transporter in Fusarium graminearum, FgAtm1 regulates the activity of cytosolic Fe-S proteins via transporting GSH-linked [2Fe-2S] clusters from mitochondria into cytoplasm. The lack of FgAtm1 reduces the activity of cytosolic Fe-S proteins nitrite reductase and xanthine dehydrogenase, which causes high expression of iron regulator FgHapX via activating the transcription factor FgAreA. FgHapX represses transcription of the genes for iron-consuming proteins, but activates the genes for iron-acquisition proteins. The image indicates that the growth of ΔFgAtm1 is accelerated by feeding with each of the final catalytic products of cytosolic Fe-S proteins. Wang et al.

Image Credit: Z Wang, Y Yin, and Z Ma (2019)

Opinion

Promotion and induction of liver cancer by gut microbiome-mediated modulation of bile acids

Baolei Jia, Che Ok Jeon

PLOS Pathogens: published September 5, 2019 | https://doi.org/10.1371/journal.ppat.1007954

Pearls

Getting in: The structural biology of malaria invasion

Hirdesh Kumar, Niraj H. Tolia

PLOS Pathogens: published September 5, 2019 | https://doi.org/10.1371/journal.ppat.1007943

Conidial surface proteins at the interface of fungal infections

Matthew G. Blango, Olaf Kniemeyer, Axel A. Brakhage

PLOS Pathogens: published September 12, 2019 | https://doi.org/10.1371/journal.ppat.1007939

Is reliance on an inaccurate genome sequence sabotaging your experiments?

Rodrigo P. Baptista, Jessica C. Kissinger

PLOS Pathogens: published September 12, 2019 | https://doi.org/10.1371/journal.ppat.1007901

Tuberculosis drug discovery in the CRISPR era

Jeremy Rock

PLOS Pathogens: published September 19, 2019 | https://doi.org/10.1371/journal.ppat.1007975

Emergomyces: The global rise of new dimorphic fungal pathogens

Ilan S. Schwartz, Nelesh P. Govender, Lynne Sigler, Yanping Jiang, Tsidiso G. Maphanga, Barbra Toplis, Alfred Botha, Karolina Dukik, J. Claire Hoving, Jose F. Muñoz, Sybren de Hoog, Christina A. Cuomo, Robert Colebunders, Chris Kenyon

PLOS Pathogens: published September 19, 2019 | https://doi.org/10.1371/journal.ppat.1007977

Research Articles

Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage

David Sacks, Jinal N. Bhiman, Kevin Wiehe, Jason Gorman, Peter D. Kwong, Lynn Morris, Penny L. Moore

PLOS Pathogens: published September 3, 2019 | https://doi.org/10.1371/journal.ppat.1008005

KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation

Rajnish Kumar Singh, Zachary L. Lamplugh, Fengchao Lang, Yan Yuan, Paul Lieberman, Jianxin You, Erle S. Robertson

PLOS Pathogens: published September 3, 2019 | https://doi.org/10.1371/journal.ppat.1008025

Molecular basis for functional diversity among microbial Nep1-like proteins

Tea Lenarčič, Katja Pirc, Vesna Hodnik, Isabell Albert, Jure Borišek, Alessandra Magistrato, Thorsten Nürnberger, Marjetka Podobnik, Gregor Anderluh

PLOS Pathogens: published September 3, 2019 | https://doi.org/10.1371/journal.ppat.1007951

The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus

Luiza A. de Castro-Jorge, Renan V. H. de Carvalho, Taline M. Klein, Carlos H. Hiroki, Alexandre H. Lopes, Rafaela M. Guimarães, Marcílio Jorge Fumagalli, Vitor G. Floriano, Mayara R. Agostinho, Renata Dezengrini Slhessarenko, Fernando Silva Ramalho, Thiago M. Cunha, Fernando Q. Cunha, Benedito A. L. da Fonseca, Dario S. Zamboni

PLOS Pathogens: published September 3, 2019 | https://doi.org/10.1371/journal.ppat.1007934

Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4⁺ T-lymphocyte responses and HIV-1 infection in vitro

Emily EIM Mouser, Georgios Pollakis, Hermelijn H. Smits, Jordan Thomas, Maria Yazdanbakhsh, Esther C. de Jong, William A. Paxton

PLOS Pathogens: published September 5, 2019 | https://doi.org/10.1371/journal.ppat.1007924

HupA, the main undecaprenyl pyrophosphate and phosphatidylglycerol phosphate phosphatase in Helicobacter pylori is essential for colonization of the stomach

Elise Gasiorowski, Rodolphe Auger, Xudong Tian, Samia Hicham, Chantal Ecobichon, Sophie Roure, Martin V. Douglass, M. Stephen Trent, Dominique Mengin-Lecreulx, Thierry Touzé, Ivo Gomperts Boneca

PLOS Pathogens: published September 5, 2019 | https://doi.org/10.1371/journal.ppat.1007972

The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion

Emma S. Sherling, Abigail J. Perrin, Ellen Knuepfer, Matthew R. G. Russell, Lucy M. Collinson, Louis H. Miller, Michael J. Blackman

PLOS Pathogens: published September 6, 2019 | https://doi.org/10.1371/journal.ppat.1008049

Anti-HIV potency of T-cell responses elicited by dendritic cell therapeutic vaccination

Mathieu Surenaud, Monica Montes, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Jacques Banchereau, Karolina Palucka, Jean-Daniel Lelièvre, Christine Lacabaratz, Yves Lévy

PLOS Pathogens: published September 9, 2019 | https://doi.org/10.1371/journal.ppat.1008011

The phage gene wmk is a candidate for male killing by a bacterial endosymbiont

Jessamyn I. Perlmutter, Sarah R. Bordenstein, Robert L. Unckless, Daniel P. LePage, Jason A. Metcalf, Tom Hill, Julien Martinez, Francis M. Jiggins, Seth R. Bordenstein

PLOS Pathogens: published September 10, 2019 | https://doi.org/10.1371/journal.ppat.1007936

The opportunistic pathogen Stenotrophomonas maltophilia utilizes a type IV secretion system for interbacterial killing

Ethel Bayer-Santos, William Cenens, Bruno Yasui Matsuyama, Gabriel Umaji Oka, Giancarlo Di Sessa, Izabel Del Valle Mininel, Tiago Lubiana Alves, Chuck Shaker Farah

PLOS Pathogens: published September 12, 2019 | https://doi.org/10.1371/journal.ppat.1007651

The molecular clock of Mycobacterium tuberculosis

Fabrizio Menardo, Sebastian Duchêne, Daniela Brites, Sebastien Gagneux

PLOS Pathogens: published September 12, 2019 | https://doi.org/10.1371/journal.ppat.1008067

Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival

Liang Wei Wang, Zhonghao Wang, Ina Ersing, Luis Nobre, Rui Guo, Sizun Jiang, Stephen Trudeau, Bo Zhao, Michael P. Weekes, Benjamin E. Gewurz

PLOS Pathogens: published September 13, 2019 | https://doi.org/10.1371/journal.ppat.1008030

The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis

Camilla Jensen, Kristoffer T. Bæk, Clement Gallay, Ida Thalsø-Madsen, Lijuan Xu, Ambre Jousselin, Fernando Ruiz Torrubia, Wilhelm Paulander, Ana R. Pereira, Jan-Willem Veening, Mariana G. Pinho, Dorte Frees

PLOS Pathogens: published September 13, 2019 | https://doi.org/10.1371/journal.ppat.1008044

RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection

Jae Seung Lee, Keisuke Tabata, Woan-Ing Twu, Md Shafiqur Rahman, Hee Sun Kim, Jin Bae Yu, Min Hyeok Jee, Ralf Bartenschlager, Sung Key Jang

PLOS Pathogens: published September 16, 2019 | https://doi.org/10.1371/journal.ppat.1008021

Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge

Xiaoyan Zheng, Jennifer D. Oduro, Julia D. Boehme, Lisa Borkner, Thomas Ebensen, Ulrike Heise, Marcus Gereke, Marina C. Pils, Astrid Krmpotic, Carlos A. Guzmán, Dunja Bruder, Luka Čičin-Šain

PLOS Pathogens: published September 16, 2019 | https://doi.org/10.1371/journal.ppat.1008036

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

Celia C. LaBranche, Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, Kevin O. Saunders, S. Munir Alam, Mattia Bonsignori, Mario J. Borgnia, Quentin J. Sattentau, Amanda Eaton, Kelli Greene, Hongmei Gao, Hua-Xin Liao, Wilton B. Williams, James Peacock, Haili Tang, Lautaro G. Perez, Robert J. Edwards, Thomas B. Kepler, Bette T. Korber, Peter D. Kwong, John R. Mascola, Priyamvada Acharya, Barton F. Haynes, David C. Montefiori

PLOS Pathogens: published September 17, 2019 | https://doi.org/10.1371/journal.ppat.1008026

HLA-B locus products resist degradation by the human cytomegalovirus immunoevasin US11

Cosima Zimmermann, Daniel Kowalewski, Liane Bauersfeld, Andreas Hildenbrand, Carolin Gerke, Magdalena Schwarzmüller, Vu Thuy Khanh Le-Trilling, Stefan Stevanovic, Hartmut Hengel, Frank Momburg, Anne Halenius

PLOS Pathogens: published September 17, 2019 | https://doi.org/10.1371/journal.ppat.1008040

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

Xin-Ni Lim, Chao Shan, Jan K. Marzinek, Hongping Dong, Thiam Seng Ng, Justin S. G. Ooi, Guntur Fibriansah, Jiaqi Wang, Chandra S. Verma, Peter J. Bond, Pei-Yong Shi, Shee-mei Lok

PLOS Pathogens: published September 19, 2019 | https://doi.org/10.1371/journal.ppat.1007996

A robust human norovirus replication model in zebrafish larvae

Jana Van Dycke, Annelii Ny, Nádia Conceição-Neto, Jan Maes, Myra Hosmillo, Arno Cuvry, Ian Goodfellow, Tatiane C. Nogueira, Erik Verbeken, Jelle Matthijnssens, Peter de Witte, Johan Neyts, Joana Rocha-Pereira

PLOS Pathogens: published September 19, 2019 | https://doi.org/10.1371/journal.ppat.1008009

Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes

Chester J. Joyner, Cristiana F. A. Brito, Celia L. Saney, Regina Joice Cordy, Maren L. Smith, Stacey A. Lapp, Monica Cabrera-Mora, Shuya Kyu, Nicolas Lackman, Mustafa V. Nural, Jeremy D. DeBarry, the MaHPIC Consortium, Jessica C. Kissinger, Mark P. Styczynski, F. Eun-Hyung Lee, Tracey J. Lamb, Mary R. Galinski

PLOS Pathogens: published September 19, 2019 | https://doi.org/10.1371/journal.ppat.1007974

Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion

Kai Li, Yongzhen Liu, Zengkun Xu, Yu Zhang, Dan Luo, Yulong Gao, Yingjuan Qian, Chenyi Bao, Changjun Liu, Yanping Zhang, Xiaole Qi, Hongyu Cui, Yongqiang Wang, Li Gao, Xiaomei Wang

PLOS Pathogens: published September 20, 2019 | https://doi.org/10.1371/journal.ppat.1007999

Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917

Clémence Massip, Priscilla Branchu, Nadège Bossuet-Greif, Camille V. Chagneau, Déborah Gaillard, Patricia Martin, Michèle Boury, Thomas Sécher, Damien Dubois, Jean-Philippe Nougayrède, Eric Oswald

PLOS Pathogens: published September 23, 2019 | https://doi.org/10.1371/journal.ppat.1008029

A fungal ABC transporter FgAtm1 regulates iron homeostasis via the transcription factor cascade FgAreA-HapX

Zhihui Wang, Tianling Ma, Yunyan Huang, Jing Wang, Yun Chen, H. Corby Kistler, Zhonghua Ma, Yanni Yin

PLOS Pathogens: published September 23, 2019 | https://doi.org/10.1371/journal.ppat.1007791

Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channel

Sudhanva S. Kashyap, Saurabh Verma, Denis Voronin, Sara Lustigman, Daniel Kulke, Alan P. Robertson, Richard J. Martin

PLOS Pathogens: published September 25, 2019 | https://doi.org/10.1371/journal.ppat.1008041

Persistent Crimean-Congo hemorrhagic fever virus infection in the testes and within granulomas of non-human primates with latent tuberculosis

Darci R. Smith, Charles J. Shoemaker, Xiankun Zeng, Aura R. Garrison, Joseph W. Golden, Christopher W. Schellhase, William Pratt, Franco Rossi, Collin J. Fitzpatrick, Joshua Shamblin, Adrienne Kimmel, Justine Zelko, Olivier Flusin, Jeffrey W. Koehler, Jun Liu, Kayla M. Coffin, Keersten M. Ricks, Matt A. Voorhees, Randal J. Schoepp, Connie S. Schmaljohn

PLOS Pathogens: published September 26, 2019 | https://doi.org/10.1371/journal.ppat.1008050

Long-term surviving influenza infected cells evade CD8⁺ T cell mediated clearance

Jessica K. Fiege, Ian A. Stone, Rebekah E. Dumm, Barbara M. Waring, Brian T. Fife, Judith Agudo, Brian D. Brown, Nicholas S. Heaton, Ryan A. Langlois

PLOS Pathogens: published September 26, 2019 | https://doi.org/10.1371/journal.ppat.1008077

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

Rachel B. Currier, Kathrin Ulrich, Alejandro E. Leroux, Natalie Dirdjaja, Matías Deambrosi, Mariana Bonilla, Yasar Luqman Ahmed, Lorenz Adrian, Haike Antelmann, Ursula Jakob, Marcelo A. Comini, R. Luise Krauth-Siegel

PLOS Pathogens: published September 26, 2019 | https://doi.org/10.1371/journal.ppat.1008065

Phytoplasma SAP11 effector destabilization of TCP transcription factors differentially impact development and defence of Arabidopsis versus maize

Pascal Pecher, Gabriele Moro, Maria Cristina Canale, Sylvain Capdevielle, Archana Singh, Allyson MacLean, Akiko Sugio, Chih-Horng Kuo, Joao R. S. Lopes, Saskia A. Hogenhout

PLOS Pathogens: published September 26, 2019 | https://doi.org/10.1371/journal.ppat.1008035

The fitness landscape of the African Salmonella Typhimurium ST313 strain D23580 reveals unique properties of the pBT1 plasmid

Rocío Canals, Roy R. Chaudhuri, Rebecca E. Steiner, Siân V. Owen, Natalia Quinones-Olvera, Melita A. Gordon, Michael Baym, Michael Ibba, Jay C. D. Hinton

PLOS Pathogens: published September 27, 2019 | https://doi.org/10.1371/journal.ppat.1007948

Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques

Lucas Gonzalez-Nieto, Isabelle M. Castro, Georg F. Bischof, Young C. Shin, Michael J. Ricciardi, Varian K. Bailey, Christine M. Dang, Nuria Pedreño-Lopez, Diogo M. Magnani, Keisuke Ejima, David B. Allison, Hwi Min Gil, David T. Evans, Eva G. Rakasz, Jeffrey D. Lifson, Ronald C. Desrosiers, Mauricio A. Martins

PLOS Pathogens: published September 30, 2019 | https://doi.org/10.1371/journal.ppat.1008015

Immunization with a murine cytomegalovirus based vector encoding retrovirus envelope confers strong protection from Friend retrovirus challenge infection

Nadine Bongard, Vu Thuy Khanh Le-Trilling, Anna Malyshkina, Meike Rückborn, Kerstin Wohlgemuth, Ina Wensing, Sonja Windmann, Ulf Dittmer, Mirko Trilling, Wibke Bayer

PLOS Pathogens: published September 30, 2019 | https://doi.org/10.1371/journal.ppat.1008043

Pyruvate produced by Brugia spp. via glycolysis is essential for maintaining the mutualistic association between the parasite and its endosymbiont, Wolbachia

Denis Voronin, Emily Schnall, Alexandra Grote, Shabnam Jawahar, Waleed Ali, Thomas R. Unnasch, Elodie Ghedin, Sara Lustigman

PLOS Pathogens: published September 30, 2019 | https://doi.org/10.1371/journal.ppat.1008085

Cytolethal distending toxin induces the formation of transient messenger-rich ribonucleoprotein nuclear invaginations in surviving cells

Lamia Azzi-Martin, Wencan He, Christelle Péré-Védrenne, Victoria Korolik, Chloé Alix, Martina Prochazkova-Carlotti, Jean-Luc Morel, Emilie Le Roux-Goglin, Philippe Lehours, Mojgan Djavaheri-Mergny, Christophe F. Grosset, Christine Varon, Pierre Dubus, Armelle Ménard

PLOS Pathogens: published September 30, 2019 | https://doi.org/10.1371/journal.ppat.1007921

Correction

Correction: Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype

Benjamin Hommel, Aude Sturny-Leclère, Stevenn Volant, Nathanaël Veluppillai, Magalie Duchateau, Chen-Hsin Yu, Véronique Hourdel, Hugo Varet, Mariette Matondo, John R. Perfect, Arturo Casadevall, Françoise Dromer, Alexandre Alanio

PLOS Pathogens: published September 17, 2019 | https://doi.org/10.1371/journal.ppat.1008070