Table of Contents

November 2013

The mouse host cell restricted attenuated vaccinia virus MVA is able to replicate and produce mature virions (green dots) in murine embryo fibroblasts (MEFs) lacking the cellular dual phosphatase DUSP1, involved in MAPK signaling pathway. See Cáceres et al.

Image Credit: Ana Cáceres, Beatriz Perdiguero, Carmen E. Gómez, Maria Victoria Cepeda, Carme Caelles, Carlos Oscar Sorzano, and Mariano Esteban (Centro Nacional de Biotecnología, CSIC and University of Barcelona, Spain).


Colonization Resistance: Battle of the Bugs or Ménage à Trois with the Host?

Alanna M. Spees, Christopher A. Lopez, Dawn D. Kingsbury, Sebastian E. Winter, Andreas J. Bäumler

Disease to Dirt: The Biology of Microbial Amyloids

David A. Hufnagel, Çagla Tükel, Matthew R. Chapman

The Biology and Taxonomy of Head and Body Lice—Implications for Louse-Borne Disease Prevention

Denise L. Bonilla, Lance A. Durden, Marina E. Eremeeva, Gregory A. Dasch

Baculoviruses: Sophisticated Pathogens of Insects

Rollie J. Clem, A. Lorena Passarelli

DNA Damage Repair and Bacterial Pathogens

Darja Žgur-Bertok

Research Articles

A Unique SUMO-2-Interacting Motif within LANA Is Essential for KSHV Latency

Qiliang Cai, Shen Cai, Caixia Zhu, Suhbash C. Verma, Ji-Young Choi, Erle S. Robertson

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

Devin Sok, Uri Laserson, Jonathan Laserson, Yi Liu, Francois Vigneault, Jean-Philippe Julien, Bryan Briney, Alejandra Ramos, Karen F. Saye, Khoa Le, Alison Mahan, Shenshen Wang, Mehran Kardar, Gur Yaari, Laura M. Walker, Birgitte B. Simen, Elizabeth P. St. John, Po-Ying Chan-Hui, Kristine Swiderek, Stephen H. Kleinstein, Galit Alter, Michael S. Seaman, Arup K. Chakraborty, Daphne Koller, Ian A. Wilson, George M. Church, Dennis R. Burton, Pascal Poignard

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A Small Molecule Glycosaminoglycan Mimetic Blocks Plasmodium Invasion of the Mosquito Midgut

Derrick K. Mathias, Rebecca Pastrana-Mena, Elisabetta Ranucci, Dingyin Tao, Paolo Ferruti, Corrie Ortega, Gregory O. Staples, Joseph Zaia, Eizo Takashima, Takafumi Tsuboi, Natalie A. Borg, Luisella Verotta, Rhoel R. Dinglasan

Unraveling a Three-Step Spatiotemporal Mechanism of Triggering of Receptor-Induced Nipah Virus Fusion and Cell Entry

Qian Liu, Jacquelyn A. Stone, Birgit Bradel-Tretheway, Jeffrey Dabundo, Javier A. Benavides Montano, Jennifer Santos-Montanez, Scott B. Biering, Anthony V. Nicola, Ronald M. Iorio, Xiaonan Lu, Hector C. Aguilar

Haploid Genetic Screens Identify an Essential Role for PLP2 in the Downregulation of Novel Plasma Membrane Targets by Viral E3 Ubiquitin Ligases

Richard T. Timms, Lidia M. Duncan, Iva A. Tchasovnikarova, Robin Antrobus, Duncan L. Smith, Gordon Dougan, Michael P. Weekes, Paul J. Lehner

Type I and Type III Interferons Drive Redundant Amplification Loops to Induce a Transcriptional Signature in Influenza-Infected Airway Epithelia

Stefania Crotta, Sophia Davidson, Tanel Mahlakoiv, Christophe J. Desmet, Matthew R. Buckwalter, Matthew L. Albert, Peter Staeheli, Andreas Wack

SPOC1-Mediated Antiviral Host Cell Response Is Antagonized Early in Human Adenovirus Type 5 Infection

Sabrina Schreiner, Sarah Kinkley, Carolin Bürck, Andreas Mund, Peter Wimmer, Tobias Schubert, Peter Groitl, Hans Will, Thomas Dobner

The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells

Sandeep Gupta, Johannes S. Gach, Juan C. Becerra, Tran B. Phan, Jeffrey Pudney, Zina Moldoveanu, Sarah B. Joseph, Gary Landucci, Medalyn Jude Supnet, Li-Hua Ping, Davide Corti, Brian Moldt, Zdenek Hel, Antonio Lanzavecchia, Ruth M. Ruprecht, Dennis R. Burton, Jiri Mestecky, Deborah J. Anderson, Donald N. Forthal

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Brd4 Is Displaced from HPV Replication Factories as They Expand and Amplify Viral DNA

Nozomi Sakakibara, Dan Chen, Moon Kyoo Jang, Dong Wook Kang, Hans F. Luecke, Shwu-Yuan Wu, Cheng-Ming Chiang, Alison A. McBride

Mode of Parainfluenza Virus Transmission Determines the Dynamics of Primary Infection and Protection from Reinfection

Crystal W. Burke, Olga Bridges, Sherri Brown, Richard Rahija, Charles J. Russell

Killer Bee Molecules: Antimicrobial Peptides as Effector Molecules to Target Sporogonic Stages of Plasmodium

Victoria Carter, Ann Underhill, Ibrahima Baber, Lakamy Sylla, Mounirou Baby, Isabelle Larget-Thiery, Agnès Zettor, Catherine Bourgouin, Ülo Langel, Ingrid Faye, Laszlo Otvos, John D. Wade, Mamadou B. Coulibaly, Sekou F. Traore, Frederic Tripet, Paul Eggleston, Hilary Hurd

Can Non-lytic CD8+ T Cells Drive HIV-1 Escape?

Nafisa-Katrin Seich al Basatena, Konstantinos Chatzimichalis, Frederik Graw, Simon D. W. Frost, Roland R. Regoes, Becca Asquith

Deletion of the α-(1,3)-Glucan Synthase Genes Induces a Restructuring of the Conidial Cell Wall Responsible for the Avirulence of Aspergillus fumigatus

Anne Beauvais, Silvia Bozza, Olaf Kniemeyer, Céline Formosa, Viviane Balloy, Christine Henry, Robert W. Roberson, Etienne Dague, Michel Chignard, Axel A. Brakhage, Luigina Romani, Jean-Paul Latgé

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Involvement of the Cellular Phosphatase DUSP1 in Vaccinia Virus Infection

Ana Cáceres, Beatriz Perdiguero, Carmen E. Gómez, Maria Victoria Cepeda, Carme Caelles, Carlos Oscar Sorzano, Mariano Esteban

Intracellular Interferons in Fish: A Unique Means to Combat Viral Infection

Ming-Xian Chang, Jun Zou, Pin Nie, Bei Huang, Zhanglong Yu, Bertrand Collet, Chris J. Secombes

Identification of the Adenovirus E4orf4 Protein Binding Site on the B55α and Cdc55 Regulatory Subunits of PP2A: Implications for PP2A Function, Tumor Cell Killing and Viral Replication

Melissa Z. Mui, Michael Kucharski, Marie-Joëlle Miron, Woosuk Steve Hur, Albert M. Berghuis, Paola Blanchette, Philip E. Branton

A Novel Membrane Sensor Controls the Localization and ArfGEF Activity of Bacterial RalF

Marcia Folly-Klan, Eric Alix, Danièle Stalder, Pampa Ray, Lionel V. Duarte, Anna Delprato, Mahel Zeghouf, Bruno Antonny, Valérie Campanacci, Craig R. Roy, Jacqueline Cherfils

A Viral Genome Landscape of RNA Polyadenylation from KSHV Latent to Lytic Infection

Vladimir Majerciak, Ting Ni, Wenjing Yang, Bowen Meng, Jun Zhu, Zhi-Ming Zheng

Conservative Sex and the Benefits of Transformation in Streptococcus pneumoniae

Daniel J. P. Engelmoer, Ian Donaldson, Daniel E. Rozen

Natural Selection Promotes Antigenic Evolvability

Christopher J. Graves, Vera I. D. Ros, Brian Stevenson, Paul D. Sniegowski, Dustin Brisson

Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages

Julia Esser-von Bieren, Ilaria Mosconi, Romain Guiet, Alessandra Piersgilli, Beatrice Volpe, Fei Chen, William C. Gause, Arne Seitz, J. Sjef Verbeek, Nicola L. Harris

Type I Interferon Protects against Pneumococcal Invasive Disease by Inhibiting Bacterial Transmigration across the Lung

Kim S. LeMessurier, Hans Häcker, Liying Chi, Elaine Tuomanen, Vanessa Redecke

Turning Defense into Offense: Defensin Mimetics as Novel Antibiotics Targeting Lipid II

Kristen M. Varney, Alexandre M. J. J. Bonvin, Marzena Pazgier, Jakob Malin, Wenbo Yu, Eugene Ateh, Taiji Oashi, Wuyuan Lu, Jing Huang, Marlies Diepeveen-de Buin, Joseph Bryant, Eefjan Breukink, Alexander D. MacKerell Jr, Erik P. H. de Leeuw

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The Inflammatory Kinase MAP4K4 Promotes Reactivation of Kaposi's Sarcoma Herpesvirus and Enhances the Invasiveness of Infected Endothelial Cells

Darya A. Haas, Kiran Bala, Guntram Büsche, Magdalena Weidner-Glunde, Susann Santag, Semra Kati, Silvia Gramolelli, Modester Damas, Oliver Dittrich-Breiholz, Michael Kracht, Jessica Rückert, Zoltan Varga, György Keri, Thomas F. Schulz

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