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Table of Contents

March 2016

Optical microscope photography of Flamingolepis liguloides infecting Artemia parthenogenetica, showing carotenoid-rich lipid droplets induced by the parasite. Sánchez et al.

Image Credit: Sample provided by Marta I. Sánchez and photography taken by Javier Díaz Real (Estación Biológica de Doñana, CSIC).

Research Matters

Research Articles

siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection

Sheli R. Radoshitzky, Gianluca Pegoraro, Xiǎolì Chī, Lián Dǒng, Chih-Yuan Chiang, Lucas Jozwick, Jeremiah C. Clester, Christopher L. Cooper, Duane Courier, David P. Langan, Knashka Underwood, Kathleen A. Kuehl, Mei G. Sun, Yíngyún Caì, Shuǐqìng Yú, Robin Burk, Rouzbeh Zamani, Krishna Kota, Jens H. Kuhn, Sina Bavari

Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria

Brandi D. Freeman, Yuri C. Martins, Oscar B. Akide-Ndunge, Fernando P. Bruno, Hua Wang, Herbert B. Tanowitz, David C. Spray, Mahalia S. Desruisseaux

Cold-Adapted Viral Attenuation (CAVA): Highly Temperature Sensitive Polioviruses as Novel Vaccine Strains for a Next Generation Inactivated Poliovirus Vaccine

Barbara P. Sanders, Isabel de los Rios Oakes, Vladimir van Hoek, Viki Bockstal, Tobias Kamphuis, Taco G. Uil, Yutong Song, Gillian Cooper, Laura E. Crawt, Javier Martín, Roland Zahn, John Lewis, Eckard Wimmer, Jerome H. H. V. Custers, Hanneke Schuitemaker, Jeronimo Cello, Diana Edo-Matas

PI3Kγ Is Critical for Dendritic Cell-Mediated CD8+ T Cell Priming and Viral Clearance during Influenza Virus Infection

Samuel Philip Nobs, Christoph Schneider, Alex Kaspar Heer, Jatta Huotari, Ari Helenius, Manfred Kopf

Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells

Melanie J. Harriff, Elham Karamooz, Ansen Burr, Wilmon F. Grant, Elizabeth T. Canfield, Michelle L. Sorensen, Luis F. Moita, David M. Lewinsohn

The E3 Ligase APIP10 Connects the Effector AvrPiz-t to the NLR Receptor Piz-t in Rice

Chan Ho Park, Gautam Shirsekar, Maria Bellizzi, Songbiao Chen, Pattavipha Songkumarn, Xin Xie, Xuetao Shi, Yuese Ning, Bo Zhou, Pavinee Suttiviriya, Mo Wang, Kenji Umemura, Guo-Liang Wang

Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection

Kshitij Wagh, Tanmoy Bhattacharya, Carolyn Williamson, Alex Robles, Madeleine Bayne, Jetta Garrity, Michael Rist, Cecilia Rademeyer, Hyejin Yoon, Alan Lapedes, Hongmei Gao, Kelli Greene, Mark K. Louder, Rui Kong, Salim Abdool Karim, Dennis R. Burton, Dan H. Barouch, Michel C. Nussenzweig, John R. Mascola, Lynn Morris, David C. Montefiori, Bette Korber, Michael S. Seaman

Candida glabrata Binding to Candida albicans Hyphae Enables Its Development in Oropharyngeal Candidiasis

Swetha Tati, Peter Davidow, Andrew McCall, Elizabeth Hwang-Wong, Isolde G. Rojas, Brendan Cormack, Mira Edgerton

Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

Yunjeong Kim, Hongwei Liu, Anushka C. Galasiti Kankanamalage, Sahani Weerasekara, Duy H. Hua, William C. Groutas, Kyeong-Ok Chang, Niels C. Pedersen

Related Articles

Bacillus bombysepticus α-Toxin Binding to G Protein-Coupled Receptor Kinase 2 Regulates cAMP/PKA Signaling Pathway to Induce Host Death

Ping Lin, Tingcai Cheng, Sanyuan Ma, Junping Gao, Shengkai Jin, Liang Jiang, Qingyou Xia

The Type III Secretion Translocation Pore Senses Host Cell Contact

Erin I. Armentrout, Arne Rietsch

An Immature Myeloid/Myeloid-Suppressor Cell Response Associated with Necrotizing Inflammation Mediates Lethal Pulmonary Tularemia

Sivakumar Periasamy, Dorina Avram, Amanda McCabe, Katherine C. MacNamara, Timothy J. Sellati, Jonathan A. Harton

Genome-wide siRNA Screening at Biosafety Level 4 Reveals a Crucial Role for Fibrillarin in Henipavirus Infection

Celine Deffrasnes, Glenn A. Marsh, Chwan Hong Foo, Christina L. Rootes, Cathryn M. Gould, Julian Grusovin, Paul Monaghan, Michael K. Lo, S. Mark Tompkins, Timothy E. Adams, John W. Lowenthal, Kaylene J. Simpson, Cameron R. Stewart, Andrew G. D. Bean, Lin-Fa Wang

The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles

Christopher M. Ziegler, Philip Eisenhauer, Emily A. Bruce, Marion E. Weir, Benjamin R. King, Joseph P. Klaus, Dimitry N. Krementsov, David J. Shirley, Bryan A. Ballif, Jason Botten

Activation of Plant Innate Immunity by Extracellular High Mobility Group Box 3 and Its Inhibition by Salicylic Acid

Hyong Woo Choi, Murli Manohar, Patricia Manosalva, Miaoying Tian, Magali Moreau, Daniel F. Klessig

Locally Produced IL-10 Limits Cutaneous Vaccinia Virus Spread

Stephanie S. Cush, Glennys V. Reynoso, Olena Kamenyeva, Jack R. Bennink, Jonathan W. Yewdell, Heather D. Hickman

Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis

Jun-ichi Furusawa, Izuru Mizoguchi, Yukino Chiba, Masayuki Hisada, Fumie Kobayashi, Hiroki Yoshida, Susumu Nakae, Akihiko Tsuchida, Tetsuya Matsumoto, Hideo Ema, Junichiro Mizuguchi, Takayuki Yoshimoto

In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis

Lucy C. K. Bell, Gabriele Pollara, Mellissa Pascoe, Gillian S. Tomlinson, Rannakoe J. Lehloenya, Jennifer Roe, Richard Meldau, Robert F. Miller, Alan Ramsay, Benjamin M. Chain, Keertan Dheda, Mahdad Noursadeghi

Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination

Alison E. Mahan, Madeleine F. Jennewein, Todd Suscovich, Kendall Dionne, Jacquelynne Tedesco, Amy W. Chung, Hendrik Streeck, Maria Pau, Hanneke Schuitemaker, Don Francis, Patricia Fast, Dagna Laufer, Bruce D. Walker, Lindsey Baden, Dan H. Barouch, Galit Alter

Related Articles

PSGL-1 on Leukocytes is a Critical Component of the Host Immune Response against Invasive Pneumococcal Disease

Elisa Ramos-Sevillano, Ana Urzainqui, Belén de Andrés, Rafael González-Tajuelo, Mirian Domenech, Fernando González-Camacho, Francisco Sánchez-Madrid, Jeremy S. Brown, Ernesto García, Jose Yuste

TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection

Pushpa Jayaraman, Miye K. Jacques, Chen Zhu, Katherine M. Steblenko, Britni L. Stowell, Asaf Madi, Ana C. Anderson, Vijay K. Kuchroo, Samuel M. Behar

Experimental Cerebral Malaria Spreads along the Rostral Migratory Stream

Angelika Hoffmann, Johannes Pfeil, Julieta Alfonso, Felix T. Kurz, Felix Sahm, Sabine Heiland, Hannah Monyer, Martin Bendszus, Ann-Kristin Mueller, Xavier Helluy, Mirko Pham

Acetylation of Lysine 201 Inhibits the DNA-Binding Ability of PhoP to Regulate Salmonella Virulence

Jie Ren, Yu Sang, Yongcong Tan, Jing Tao, Jinjing Ni, Shuting Liu, Xia Fan, Wei Zhao, Jie Lu, Wenjuan Wu, Yu-Feng Yao

A Numerically Subdominant CD8 T Cell Response to Matrix Protein of Respiratory Syncytial Virus Controls Infection with Limited Immunopathology

Jie Liu, Elias K. Haddad, Joshua Marceau, Kaitlyn M. Morabito, Srinivas S. Rao, Ali Filali-Mouhim, Rafick-Pierre Sekaly, Barney S. Graham

The Myeloid LSECtin Is a DAP12-Coupled Receptor That Is Crucial for Inflammatory Response Induced by Ebola Virus Glycoprotein

Dianyuan Zhao, Xintao Han, Xuexing Zheng, Hualei Wang, Zaopeng Yang, Di Liu, Ke Han, Jing Liu, Xiaowen Wang, Wenting Yang, Qingyang Dong, Songtao Yang, Xianzhu Xia, Li Tang, Fuchu He

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The Bacterial Flagellar Type III Export Gate Complex Is a Dual Fuel Engine That Can Use Both H+ and Na+ for Flagellar Protein Export

Tohru Minamino, Yusuke V. Morimoto, Noritaka Hara, Phillip D. Aldridge, Keiichi Namba

Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody

Xiaohua Ye, Chen Fan, Zhiqiang Ku, Teng Zuo, Liangliang Kong, Chao Zhang, Jinping Shi, Qingwei Liu, Tan Chen, Yingyi Zhang, Wen Jiang, Linqi Zhang, Zhong Huang, Yao Cong

When Parasites Are Good for Health: Cestode Parasitism Increases Resistance to Arsenic in Brine Shrimps

Marta I. Sánchez, Inès Pons, Mónica Martínez-Haro, Mark A. Taggart, Thomas Lenormand, Andy J. Green

Related Articles

NAD+-Glycohydrolase Promotes Intracellular Survival of Group A Streptococcus

Onkar Sharma, Maghnus O’Seaghdha, Jorge J. Velarde, Michael R. Wessels

Integrated and Total HIV-1 DNA Predict Ex Vivo Viral Outgrowth

Maja Kiselinova, Ward De Spiegelaere, Maria Jose Buzon, Eva Malatinkova, Mathias Lichterfeld, Linos Vandekerckhove

Related Articles

Morphology and Molecular Composition of Purified Bovine Viral Diarrhea Virus Envelope

Nathalie Callens, Britta Brügger, Pierre Bonnafous, Hervé Drobecq, Mathias J. Gerl, Thomas Krey, Gleyder Roman-Sosa, Till Rümenapf, Olivier Lambert, Jean Dubuisson, Yves Rouillé

PKR Transduces MDA5-Dependent Signals for Type I IFN Induction

Alissa M. Pham, Felicia Gilfoy Santa Maria, Tanaya Lahiri, Eugene Friedman, Isabelle J. Marié, David E. Levy

Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection

Anshu P. Gounder, Nicolle D. Myers, Piper M. Treuting, Beth A. Bromme, Sarah S. Wilson, Mayim E. Wiens, Wuyuan Lu, André J. Ouellette, Katherine R. Spindler, William C. Parks, Jason G. Smith