Rhinovirus C is a significant cause of respiratory illness world-wide, yet little remains known about the life cycle of this pathogen in human airway epithelial cells. Immunofluorescence detection of double-stranded RNA (magenta) in a well-differentiated model of human airway epithelium following rhinovirus-C15 infection reveals ongoing viral replication in Forkhead Box J1 (FoxJ1; gray) – positive ciliated cells. Motile cilia are visualized by acetylated α-tubulin staining (green).
Image Credit: Talita Bianca Gagliardi
Review
Advances and gaps in SARS-CoV-2 infection models
PLOS Pathogens: published January 13, 2022 | https://doi.org/10.1371/journal.ppat.1010161
Research Articles
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Engineering, decoding and systems-level characterization of chimpanzee cytomegalovirus
PLOS Pathogens: published January 4, 2022 | https://doi.org/10.1371/journal.ppat.1010193
RplI interacts with 5’ UTR of exsA to repress its translation and type III secretion system in Pseudomonas aeruginosa
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Structure of a bacterial Rhs effector exported by the type VI secretion system
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Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice
PLOS Pathogens: published January 5, 2022 | https://doi.org/10.1371/journal.ppat.1010183
Variability in an effector gene promoter of a necrotrophic fungal pathogen dictates epistasis and effector-triggered susceptibility in wheat
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Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies
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B cell overexpression of FCRL5 and PD-1 is associated with low antibody titers in HCV infection
PLOS Pathogens: published January 6, 2022 | https://doi.org/10.1371/journal.ppat.1010179
Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs
PLOS Pathogens: published January 6, 2022 | https://doi.org/10.1371/journal.ppat.1010202
Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium
PLOS Pathogens: published January 7, 2022 | https://doi.org/10.1371/journal.ppat.1010159
ApoA-I mimetics reduce systemic and gut inflammation in chronic treated HIV
PLOS Pathogens: published January 7, 2022 | https://doi.org/10.1371/journal.ppat.1010160
Control of β-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence
PLOS Pathogens: published January 7, 2022 | https://doi.org/10.1371/journal.ppat.1010192
Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages
PLOS Pathogens: published January 10, 2022 | https://doi.org/10.1371/journal.ppat.1010166
Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19
PLOS Pathogens: published January 10, 2022 | https://doi.org/10.1371/journal.ppat.1010176
Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins
PLOS Pathogens: published January 10, 2022 | https://doi.org/10.1371/journal.ppat.1010226
Epstein-Barr Virus BGLF2 commandeers RISC to interfere with cellular miRNA function
PLOS Pathogens: published January 10, 2022 | https://doi.org/10.1371/journal.ppat.1010235
SARS-CoV-2 variants with reduced infectivity and varied sensitivity to the BNT162b2 vaccine are developed during the course of infection
PLOS Pathogens: published January 12, 2022 | https://doi.org/10.1371/journal.ppat.1010242
Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production
PLOS Pathogens: published January 13, 2022 | https://doi.org/10.1371/journal.ppat.1009828
Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells
PLOS Pathogens: published January 13, 2022 | https://doi.org/10.1371/journal.ppat.1010171
EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22
PLOS Pathogens: published January 13, 2022 | https://doi.org/10.1371/journal.ppat.1010200
Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection
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Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p62-mediated macroautophagy
PLOS Pathogens: published January 14, 2022 | https://doi.org/10.1371/journal.ppat.1010204
Revealing spatio-temporal dynamics with long-term trypanosomatid live-cell imaging
PLOS Pathogens: published January 18, 2022 | https://doi.org/10.1371/journal.ppat.1010218
Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection
PLOS Pathogens: published January 18, 2022 | https://doi.org/10.1371/journal.ppat.1010227
A Two-tiered functional screen identifies herpesviral transcriptional modifiers and their essential domains
PLOS Pathogens: published January 18, 2022 | https://doi.org/10.1371/journal.ppat.1010236
The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription
PLOS Pathogens: published January 18, 2022 | https://doi.org/10.1371/journal.ppat.1010245
The c-MET receptor tyrosine kinase contributes to neutrophil-driven pathology in cutaneous leishmaniasis
PLOS Pathogens: published January 18, 2022 | https://doi.org/10.1371/journal.ppat.1010247
Functional analysis of ADARs in planarians supports a bilaterian ancestral role in suppressing double-stranded RNA-response
PLOS Pathogens: published January 18, 2022 | https://doi.org/10.1371/journal.ppat.1010250
Immunopeptidomic analysis of influenza A virus infected human tissues identifies internal proteins as a rich source of HLA ligands
PLOS Pathogens: published January 20, 2022 | https://doi.org/10.1371/journal.ppat.1009894
Pre-vaccination frequency of circulatory Tfh is associated with robust immune response to TV003 dengue vaccine
PLOS Pathogens: published January 21, 2022 | https://doi.org/10.1371/journal.ppat.1009903
A yellow fever virus NS4B inhibitor not only suppresses viral replication, but also enhances the virus activation of RIG-I-like receptor-mediated innate immune response
PLOS Pathogens: published January 21, 2022 | https://doi.org/10.1371/journal.ppat.1010271
Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication
PLOS Pathogens: published January 24, 2022 | https://doi.org/10.1371/journal.ppat.1009718
Shoc2 recognizes bacterial flagellin and mediates antibacterial Erk/Stat signaling in an invertebrate
PLOS Pathogens: published January 24, 2022 | https://doi.org/10.1371/journal.ppat.1010253
Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 immune responses
PLOS Pathogens: published January 24, 2022 | https://doi.org/10.1371/journal.ppat.1010255
Turnip mosaic virus co-opts the vacuolar sorting receptor VSR4 to promote viral genome replication in plants by targeting viral replication vesicles to the endosome
PLOS Pathogens: published January 24, 2022 | https://doi.org/10.1371/journal.ppat.1010257
Herpes simplex virus-1 utilizes the host actin cytoskeleton for its release from axonal growth cones
PLOS Pathogens: published January 24, 2022 | https://doi.org/10.1371/journal.ppat.1010264
Expansion microscopy of Plasmodium gametocytes reveals the molecular architecture of a bipartite microtubule organisation centre coordinating mitosis with axoneme assembly
PLOS Pathogens: published January 25, 2022 | https://doi.org/10.1371/journal.ppat.1010223
Peptidoglycan editing in non-proliferating intracellular Salmonella as source of interference with immune signaling
PLOS Pathogens: published January 25, 2022 | https://doi.org/10.1371/journal.ppat.1010241
New insights into the role of endosomal proteins for African swine fever virus infection
PLOS Pathogens: published January 26, 2022 | https://doi.org/10.1371/journal.ppat.1009784
Importin/exportin-mediated nucleocytoplasmic shuttling of cucumber mosaic virus 2b protein is required for 2b’s efficient suppression of RNA silencing
PLOS Pathogens: published January 26, 2022 | https://doi.org/10.1371/journal.ppat.1010267
Access to highly specialized growth substrates and production of epithelial immunomodulatory metabolites determine survival of Haemophilus influenzae in human airway epithelial cells
PLOS Pathogens: published January 27, 2022 | https://doi.org/10.1371/journal.ppat.1010209
Guanosine inhibits hepatitis C virus replication and increases indel frequencies, associated with altered intracellular nucleotide pools
PLOS Pathogens: published January 27, 2022 | https://doi.org/10.1371/journal.ppat.1010210
TDRD3 is an antiviral restriction factor that promotes IFN signaling with G3BP1
PLOS Pathogens: published January 27, 2022 | https://doi.org/10.1371/journal.ppat.1010249
African swine fever virus I267L acts as an important virulence factor by inhibiting RNA polymerase III-RIG-I-mediated innate immunity
PLOS Pathogens: published January 28, 2022 | https://doi.org/10.1371/journal.ppat.1010270
Model-based inference of neutralizing antibody avidities against influenza virus
PLOS Pathogens: published January 31, 2022 | https://doi.org/10.1371/journal.ppat.1010243
Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions
PLOS Pathogens: published January 31, 2022 | https://doi.org/10.1371/journal.ppat.1010280
Absence of signal peptide peptidase in peripheral sensory neurons affects latency-reactivation in HSV-1 ocularly infected mice
PLOS Pathogens: published January 31, 2022 | https://doi.org/10.1371/journal.ppat.1010281
Corrections
Correction: Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19
PLOS Pathogens: published January 5, 2022 | https://doi.org/10.1371/journal.ppat.1010220
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PLOS Pathogens: published January 25, 2022 | https://doi.org/10.1371/journal.ppat.1010263