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Table of Contents

February 2016

Each row of the figure shows several cells of a different trypanosome species or strain. Characteristic cellular waveforms are identifiable with the three-dimensional views of single cells. Additionally, the variation between individual snapshots can be visualised. Trypanosomes are incessant swimmers and thus, there is no resting morphology that can be described. In fact, the product of physical parameters of the cell, the swimming capacity and the microenvironment give the parasites their characteristic appearance, here termed the cellular waveform, which could explain species-specific dissemination and annidation in the mammalian host (see Engstler et al., Fig. 5).

Image Credit: Engstler et al.

Viewpoints

Pearls

Emerging Paramyxoviruses: Receptor Tropism and Zoonotic Potential

Antra Zeltina, Thomas A. Bowden, Benhur Lee

SeXX Matters in Infectious Disease Pathogenesis

Landon G. vom Steeg, Sabra L. Klein

Go Forth and Colonize: Dispersal from Clinically Important Microbial Biofilms

Priya Uppuluri, Jose L. Lopez-Ribot

The March towards a Vaccine for Congenital CMV: Rationale and Models

Kristy M. Bialas, Sallie R. Permar

When the Fight against Fungi Goes Wrong

Xiaowen Wang, Frank L. van de Veerdonk

Review

Yeast as a Heterologous Model System to Uncover Type III Effector Function

Crina Popa, Núria S. Coll, Marc Valls, Guido Sessa

Research Matters

A Virological Perspective on Cancer

Blossom Damania

Research Articles

Influenza Virus Targets Class I MHC-Educated NK Cells for Immunoevasion

Ahmad Bakur Mahmoud, Megan M. Tu, Andrew Wight, Haggag S. Zein, Mir Munir A. Rahim, Seung-Hwan Lee, Harman S. Sekhon, Earl G. Brown, Andrew P. Makrigiannis

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High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling

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Gabriela C. Olivera, Xiaoyuan Ren, Suman K. Vodnala, Jun Lu, Lucia Coppo, Chaniya Leepiyasakulchai, Arne Holmgren, Krister Kristensson, Martin E. Rottenberg

Quantitative Proteomics Uncovers Novel Factors Involved in Developmental Differentiation of Trypanosoma brucei

Mario Dejung, Ines Subota, Ferdinand Bucerius, Gülcin Dindar, Anja Freiwald, Markus Engstler, Michael Boshart, Falk Butter, Christian J. Janzen

Reverse Genetics for Fusogenic Bat-Borne Orthoreovirus Associated with Acute Respiratory Tract Infections in Humans: Role of Outer Capsid Protein σC in Viral Replication and Pathogenesis

Takahiro Kawagishi, Yuta Kanai, Hideki Tani, Masayuki Shimojima, Masayuki Saijo, Yoshiharu Matsuura, Takeshi Kobayashi

Cytokinin Production by the Rice Blast Fungus Is a Pivotal Requirement for Full Virulence

Emilie Chanclud, Anna Kisiala, Neil R. J Emery, Véronique Chalvon, Aurélie Ducasse, Corinne Romiti-Michel, Antoine Gravot, Thomas Kroj, Jean-Benoit Morel

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Sumaiyya Thawer, Jennifer Auret, Corinna Schnoeller, Alisha Chetty, Katherine Smith, Matthew Darby, Luke Roberts, Rosie-Marie Mackay, Harry J. Whitwell, John F. Timms, Jens Madsen, Murray E. Selkirk, Frank Brombacher, Howard William Clark, William G. C. Horsnell

ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs

Wei Chen, Senlin Li, Huansha Yu, Xing Liu, Lulu Huang, Qiang Wang, Heng Liu, Ye Cui, Yijun Tang, Peng Zhang, Chen Wang

Neurons are the Primary Target Cell for the Brain-Tropic Intracellular Parasite Toxoplasma gondii

Carla M. Cabral, Shraddha Tuladhar, Hans K. Dietrich, Elizabeth Nguyen, Wes R. MacDonald, Tapasya Trivedi, Asha Devineni, Anita A. Koshy

Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface

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Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication

Giuseppe Balistreri, Johanna Viiliäinen, Mikko Turunen, Raquel Diaz, Lauri Lyly, Pirita Pekkonen, Juha Rantala, Krista Ojala, Grzegorz Sarek, Mari Teesalu, Oxana Denisova, Karita Peltonen, Ilkka Julkunen, Markku Varjosalo, Denis Kainov, Olli Kallioniemi, Marikki Laiho, Jussi Taipale, Sampsa Hautaniemi, Päivi M. Ojala

Establishment of a Wolbachia Superinfection in Aedes aegypti Mosquitoes as a Potential Approach for Future Resistance Management

D. Albert Joubert, Thomas Walker, Lauren B. Carrington, Jyotika Taneja De Bruyne, Duong Hue T. Kien, Nhat Le Thanh Hoang, Nguyen Van Vinh Chau, Iñaki Iturbe-Ormaetxe, Cameron P. Simmons, Scott L. O’Neill

Transcriptome-Wide Analysis of Hepatitis B Virus-Mediated Changes to Normal Hepatocyte Gene Expression

Jason Lamontagne, Joshua C. Mell, Michael J. Bouchard

HMGB1 Is Involved in IFN-α Production and TRAIL Expression by HIV-1-Exposed Plasmacytoid Dendritic Cells: Impact of the Crosstalk with NK Cells

Héla Saïdi, Marlène Bras, Pauline Formaglio, Marie-Thérèse Melki, Bruno Charbit, Jean-Philippe Herbeuval, Marie-Lise Gougeon

MicroRNAs Are Involved in the Regulation of Ovary Development in the Pathogenic Blood Fluke Schistosoma japonicum

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Species-Specific Adaptations of Trypanosome Morphology and Motility to the Mammalian Host

Joel L. Bargul, Jamin Jung, Francis A. McOdimba, Collins O. Omogo, Vincent O. Adung’a, Timothy Krüger, Daniel K. Masiga, Markus Engstler

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Resistance to Bacillus thuringiensis Mediated by an ABC Transporter Mutation Increases Susceptibility to Toxins from Other Bacteria in an Invasive Insect

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The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response

Anna Brestovitsky, Keren Nebenzahl-Sharon, Peter Kechker, Rakefet Sharf, Tamar Kleinberger

Involvement of the 3’ Untranslated Region in Encapsidation of the Hepatitis C Virus

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Multiple Novel Functions of Henipavirus O-glycans: The First O-glycan Functions Identified in the Paramyxovirus Family

Jacquelyn A. Stone, Anthony V. Nicola, Linda G. Baum, Hector C. Aguilar

The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites

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Viral Replication Protein Inhibits Cellular Cofilin Actin Depolymerization Factor to Regulate the Actin Network and Promote Viral Replicase Assembly

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