April 2016

Hepatitis C virus (HCV) particles closely mimic human very-low-density lipoproteins (VLDL) to evade humoral immunity and to facilitate cell entry. However, the principles that govern HCV association with VLDL components are poorly defined. Using an siRNA screen, we identified ABHD5 (a/b hydrolase domain containing protein 5, also known as CGI-58) as a new host factor promoting both virus assembly and release. Vieyres et al.

Image Credit: Vieyres et al.

Opinion

Harnessing the Power of Defensive Microbes: Evolutionary Implications in Nature and Disease Control

Suzanne A. Ford, Kayla C. King

PLOS Pathogens: published April 8, 2016 | https://doi.org/10.1371/journal.ppat.1005465

Pearls

Filamentous Fungi in Respiratory Infections. What Lies Beyond Aspergillosis and Mucormycosis?

Anuradha Chowdhary, Kshitij Agarwal, Jacques F. Meis

PLOS Pathogens: published April 28, 2016 | https://doi.org/10.1371/journal.ppat.1005491

Correlates of Protection against Norovirus Infection and Disease—Where Are We Now, Where Do We Go?

Sasirekha Ramani, Mary K. Estes, Robert L. Atmar

PLOS Pathogens: published April 26, 2016 | https://doi.org/10.1371/journal.ppat.1005334

Innate Resistance and Susceptibility to Norovirus Infection

Johan Nordgren, Sumit Sharma, Anita Kambhampati, Ben Lopman, Lennart Svensson

PLOS Pathogens: published April 26, 2016 | https://doi.org/10.1371/journal.ppat.1005385

Tick–Host–Pathogen Interactions: Conflict and Cooperation

José de la Fuente, Margarita Villar, Alejandro Cabezas-Cruz, Agustín Estrada-Peña, Nieves Ayllón, Pilar Alberdi

PLOS Pathogens: published April 21, 2016 | https://doi.org/10.1371/journal.ppat.1005488

Trypanosome Mitochondrial Translation and Tetracycline: No Sweat about Tet

Hassan Hashimi, Sabine Kaltenbrunner, Alena Zíková, Julius Lukeš

PLOS Pathogens: published April 21, 2016 | https://doi.org/10.1371/journal.ppat.1005492

In Vivo Transcriptional Profiling of Human Pathogenic Fungi during Infection: Reflecting the Real Life?

Stefanie Allert, Sascha Brunke, Bernhard Hube

PLOS Pathogens: published April 14, 2016 | https://doi.org/10.1371/journal.ppat.1005471

Modulation of Host Angiogenesis as a Microbial Survival Strategy and Therapeutic Target

Nir Osherov, Ronen Ben-Ami

PLOS Pathogens: published April 14, 2016 | https://doi.org/10.1371/journal.ppat.1005479

Fusarium: Molecular Diversity and Intrinsic Drug Resistance

Abdullah M. S. Al-Hatmi, Jacques F. Meis, G. Sybren de Hoog

PLOS Pathogens: published April 7, 2016 | https://doi.org/10.1371/journal.ppat.1005464

Viruses Utilize Cellular Cues in Distinct Combination to Undergo Systematic Priming and Uncoating

Madhu Sudhan Ravindran, Billy Tsai

PLOS Pathogens: published April 7, 2016 | https://doi.org/10.1371/journal.ppat.1005467

Review

Diplomatic Assistance: Can Helminth-Modulated Macrophages Act as Treatment for Inflammatory Disease?

Svenja Steinfelder, Noëlle Louise O’Regan, Susanne Hartmann

PLOS Pathogens: published April 21, 2016 | https://doi.org/10.1371/journal.ppat.1005480

Research Matters

Braving the New World

Lindsey M. Hutt-Fletcher

PLOS Pathogens: published April 28, 2016 | https://doi.org/10.1371/journal.ppat.1005417

The Tree(s) of Life: The Human Placenta and My Journey to Learn More about It

Carolyn B. Coyne

PLOS Pathogens: published April 21, 2016 | https://doi.org/10.1371/journal.ppat.1005515

From Scientific Curiosity to Public Enemy Number One in Six Short Months

Neil A. Mabbott

PLOS Pathogens: published April 14, 2016 | https://doi.org/10.1371/journal.ppat.1005371

Research Articles

The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8⁺ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi

Jonatan Ersching, José R. Vasconcelos, Camila P. Ferreira, Braulia C. Caetano, Alexandre V. Machado, Oscar Bruna–Romero, Monique A. Baron, Ludmila R. P. Ferreira, Edécio Cunha-Neto, Kenneth L. Rock, Ricardo T. Gazzinelli, Maurício M. Rodrigues

PLOS Pathogens: published April 29, 2016 | https://doi.org/10.1371/journal.ppat.1005593

Distinct Roles of Type I and Type III Interferons in Intestinal Immunity to Homologous and Heterologous Rotavirus Infections

Jian-Da Lin, Ningguo Feng, Adrish Sen, Murugabaskar Balan, Hsiang-Chi Tseng, Constance McElrath, Sergey V. Smirnov, Jianya Peng, Linda L. Yasukawa, Russell K. Durbin, Joan E. Durbin, Harry B. Greenberg, Sergei V. Kotenko

PLOS Pathogens: published April 29, 2016 | https://doi.org/10.1371/journal.ppat.1005600

The SH3BGR/STAT3 Pathway Regulates Cell Migration and Angiogenesis Induced by a Gammaherpesvirus MicroRNA

Wan Li, Qin Yan, Xiangya Ding, Chenyou Shen, Minmin Hu, Ying Zhu, Di Qin, Hongmei Lu, Brian J. Krueger, Rolf Renne, Shou-Jiang Gao, Chun Lu

PLOS Pathogens: published April 29, 2016 | https://doi.org/10.1371/journal.ppat.1005605

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics

Kristian E. Swearingen, Scott E. Lindner, Lirong Shi, Melanie J. Shears, Anke Harupa, Christine S. Hopp, Ashley M. Vaughan, Timothy A. Springer, Robert L. Moritz, Stefan H. I. Kappe, Photini Sinnis

PLOS Pathogens: published April 29, 2016 | https://doi.org/10.1371/journal.ppat.1005606

ABHD5/CGI-58, the Chanarin-Dorfman Syndrome Protein, Mobilises Lipid Stores for Hepatitis C Virus Production

Gabrielle Vieyres, Kathrin Welsch, Gisa Gerold, Juliane Gentzsch, Sina Kahl, Florian W. R. Vondran, Lars Kaderali, Thomas Pietschmann

PLOS Pathogens: published April 28, 2016 | https://doi.org/10.1371/journal.ppat.1005568

Transformed Recombinant Enrichment Profiling Rapidly Identifies HMW1 as an Intracellular Invasion Locus in Haemophilus influenzae

Joshua Chang Mell, Cristina Viadas, Javier Moleres, Sunita Sinha, Ariadna Fernández-Calvet, Eric A. Porsch, Joseph W. St. Geme III, Corey Nislow, Rosemary J. Redfield, Junkal Garmendia

PLOS Pathogens: published April 28, 2016 | https://doi.org/10.1371/journal.ppat.1005576

Bovine Leukemia Virus Small Noncoding RNAs Are Functional Elements That Regulate Replication and Contribute to Oncogenesis In Vivo

Nicolas A. Gillet, Malik Hamaidia, Alix de Brogniez, Gerónimo Gutiérrez, Nathalie Renotte, Michal Reichert, Karina Trono, Luc Willems

PLOS Pathogens: published April 28, 2016 | https://doi.org/10.1371/journal.ppat.1005588

Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV

Alison L. Hill, Daniel I. S. Rosenbloom, Edward Goldstein, Emily Hanhauser, Daniel R. Kuritzkes, Robert F. Siliciano, Timothy J. Henrich

PLOS Pathogens: published April 27, 2016 | https://doi.org/10.1371/journal.ppat.1005535

African Swine Fever Virus Undergoes Outer Envelope Disruption, Capsid Disassembly and Inner Envelope Fusion before Core Release from Multivesicular Endosomes

Bruno Hernáez, Milagros Guerra, María L. Salas, Germán Andrés

PLOS Pathogens: published April 25, 2016 | https://doi.org/10.1371/journal.ppat.1005595

Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA

Alessia Liguori, Enrico Malito, Paola Lo Surdo, Luca Fagnocchi, Francesca Cantini, Andreas F. Haag, Sébastien Brier, Mariagrazia Pizza, Isabel Delany, Matthew J. Bottomley

PLOS Pathogens: published April 22, 2016 | https://doi.org/10.1371/journal.ppat.1005557

CADM1/TSLC1 Identifies HTLV-1-Infected Cells and Determines Their Susceptibility to CTL-Mediated Lysis

Kiruthika Manivannan, Aileen G. Rowan, Yuetsu Tanaka, Graham P. Taylor, Charles R. M. Bangham

PLOS Pathogens: published April 22, 2016 | https://doi.org/10.1371/journal.ppat.1005560

Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS

Pascal Ziltener, Thomas Reinheckel, Annette Oxenius

PLOS Pathogens: published April 22, 2016 | https://doi.org/10.1371/journal.ppat.1005591

Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages

Anna Lena Jung, Cornelia Stoiber, Christina E. Herkt, Christine Schulz, Wilhelm Bertrams, Bernd Schmeck

PLOS Pathogens: published April 22, 2016 | https://doi.org/10.1371/journal.ppat.1005592

Listeriolysin O Membrane Damaging Activity Involves Arc Formation and Lineaction -- Implication for Listeria monocytogenes Escape from Phagocytic Vacuole

Yi Ruan, Saša Rezelj, Apolonija Bedina Zavec, Gregor Anderluh, Simon Scheuring

PLOS Pathogens: published April 22, 2016 | https://doi.org/10.1371/journal.ppat.1005597

Antigenic Fingerprinting following Primary RSV Infection in Young Children Identifies Novel Antigenic Sites and Reveals Unlinked Evolution of Human Antibody Repertoires to Fusion and Attachment Glycoproteins

Sandra Fuentes, Elizabeth M. Coyle, Judy Beeler, Hana Golding, Surender Khurana

PLOS Pathogens: published April 21, 2016 | https://doi.org/10.1371/journal.ppat.1005554

Early T Cell Recognition of B Cells following Epstein-Barr Virus Infection: Identifying Potential Targets for Prophylactic Vaccination

Jill M. Brooks, Heather M. Long, Rose J. Tierney, Claire Shannon-Lowe, Alison M. Leese, Martin Fitzpatrick, Graham S. Taylor, Alan B. Rickinson

PLOS Pathogens: published April 20, 2016 | https://doi.org/10.1371/journal.ppat.1005549

Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses

Yasuha Arai, Norihito Kawashita, Tomo Daidoji, Madiha S. Ibrahim, Emad M. El-Gendy, Tatsuya Takagi, Kazuo Takahashi, Yasuo Suzuki, Kazuyoshi Ikuta, Takaaki Nakaya, Tatsuo Shioda, Yohei Watanabe

PLOS Pathogens: published April 20, 2016 | https://doi.org/10.1371/journal.ppat.1005583

The Ancient Evolutionary History of Polyomaviruses

Christopher B. Buck, Koenraad Van Doorslaer, Alberto Peretti, Eileen M. Geoghegan, Michael J. Tisza, Ping An, Joshua P. Katz, James M. Pipas, Alison A. McBride, Alvin C. Camus, Alexa J. McDermott, Jennifer A. Dill, Eric Delwart, Terry F. F. Ng, Kata Farkas, Charlotte Austin, Simona Kraberger, William Davison, Diana V. Pastrana, Arvind Varsani

PLOS Pathogens: published April 19, 2016 | https://doi.org/10.1371/journal.ppat.1005574

MRSA Infections in HIV-Infected People Are Associated with Decreased MRSA-Specific Th1 Immunity

Netanya S. Utay, Annelys Roque, J. Katherina Timmer, David R. Morcock, Claire DeLeage, Anoma Somasunderam, Amy C. Weintrob, Brian K. Agan, Jacob D. Estes, Nancy F. Crum-Cianflone, Daniel C. Douek

PLOS Pathogens: published April 19, 2016 | https://doi.org/10.1371/journal.ppat.1005580

Sulforaphane Inhibits HIV Infection of Macrophages through Nrf2

Andrea Kinga Marias Furuya, Hamayun J. Sharifi, Robert M. Jellinger, Paul Cristofano, Binshan Shi, Carlos M. C. de Noronha

PLOS Pathogens: published April 19, 2016 | https://doi.org/10.1371/journal.ppat.1005581

Wolbachia Blocks Viral Genome Replication Early in Infection without a Transcriptional Response by the Endosymbiont or Host Small RNA Pathways

Stephanie M. Rainey, Julien Martinez, Melanie McFarlane, Punita Juneja, Peter Sarkies, Aleksei Lulla, Esther Schnettler, Margus Varjak, Andres Merits, Eric A. Miska, Francis M. Jiggins, Alain Kohl

PLOS Pathogens: published April 18, 2016 | https://doi.org/10.1371/journal.ppat.1005536

Structure-Guided Mutations in the Terminal Organelle Protein MG491 Cause Major Motility and Morphologic Alterations on Mycoplasma genitalium

Luca Martinelli, Luis García-Morales, Enrique Querol, Jaume Piñol, Ignacio Fita, Bárbara M. Calisto

PLOS Pathogens: published April 15, 2016 | https://doi.org/10.1371/journal.ppat.1005533

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4⁺ T-Cells to Recognition by Cytotoxic T-Lymphocytes

R. Brad Jones, Stefanie Mueller, Rachel O’Connor, Katherine Rimpel, Derek D. Sloan, Dan Karel, Hing C. Wong, Emily K. Jeng, Allison S. Thomas, James B. Whitney, So-Yon Lim, Colin Kovacs, Erika Benko, Sara Karandish, Szu-Han Huang, Maria J. Buzon, Mathias Lichterfeld, Alivelu Irrinki, Jeffrey P. Murry, Angela Tsai, Helen Yu, Romas Geleziunas, Alicja Trocha, Mario A. Ostrowski, Darrell J. Irvine, Bruce D. Walker

PLOS Pathogens: published April 15, 2016 | https://doi.org/10.1371/journal.ppat.1005545

CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells

Meagan O’Brien, Olivier Manches, Craig Wilen, Ramya Gopal, Rumana Huq, Vernon Wu, Nicole Sunseri, Nina Bhardwaj

PLOS Pathogens: published April 15, 2016 | https://doi.org/10.1371/journal.ppat.1005553

Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in Virions

Adam L. Vanarsdall, Paul W. Howard, Todd W. Wisner, David C. Johnson

PLOS Pathogens: published April 15, 2016 | https://doi.org/10.1371/journal.ppat.1005564

High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence

Julie Elisabeth Heggelund, Daniel Burschowsky, Victoria Ariel Bjørnestad, Vesna Hodnik, Gregor Anderluh, Ute Krengel

PLOS Pathogens: published April 15, 2016 | https://doi.org/10.1371/journal.ppat.1005567

P2X7 Receptor Inhibition Improves CD34 T-Cell Differentiation in HIV-Infected Immunological Nonresponders on c-ART

Inna Menkova-Garnier, Hakim Hocini, Emile Foucat, Pascaline Tisserand, Laure Bourdery, Constance Delaugerre, Clarisse Benne, Yves Lévy, Jean-Daniel Lelièvre

PLOS Pathogens: published April 15, 2016 | https://doi.org/10.1371/journal.ppat.1005571

Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection

Gene S. Tan, Paul E. Leon, Randy A. Albrecht, Irina Margine, Ariana Hirsh, Justin Bahl, Florian Krammer

PLOS Pathogens: published April 15, 2016 | https://doi.org/10.1371/journal.ppat.1005578

HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains

Chong Wang, Wenying Long, Chao Peng, Lin Hu, Qiong Zhang, Ailing Wu, Xiaoqing Zhang, Xiaotao Duan, Catherine C. L. Wong, Yuetsu Tanaka, Zongping Xia

PLOS Pathogens: published April 15, 2016 | https://doi.org/10.1371/journal.ppat.1005584

Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus

Aaron M. Collier, Outi L. Lyytinen, Yusong R. Guo, Yukimatsu Toh, Minna M. Poranen, Yizhi J. Tao

PLOS Pathogens: published April 14, 2016 | https://doi.org/10.1371/journal.ppat.1005523

PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells

Maude Rolland, Xiaojun Li, Yann Sellier, Hélène Martin, Teresa Perez-Berezo, Benjamin Rauwel, Alexandra Benchoua, Bettina Bessières, Jacqueline Aziza, Nicolas Cenac, Minhua Luo, Charlotte Casper, Marc Peschanski, Daniel Gonzalez-Dunia, Marianne Leruez-Ville, Christian Davrinche, Stéphane Chavanas

PLOS Pathogens: published April 14, 2016 | https://doi.org/10.1371/journal.ppat.1005547

The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells

Anna M. Gram, Timo Oosenbrug, Marthe F. S. Lindenbergh, Christian Büll, Anouskha Comvalius, Kathryn J. I. Dickson, Joop Wiegant, Hans Vrolijk, Robert Jan Lebbink, Ron Wolterbeek, Gosse J. Adema, Marieke Griffioen, Mirjam H. M. Heemskerk, David C. Tscharke, Lindsey M. Hutt-Fletcher, Emmanuel J. H. J. Wiertz, Rob C. Hoeben, Maaike E. Ressing

PLOS Pathogens: published April 14, 2016 | https://doi.org/10.1371/journal.ppat.1005550

IL-12p40/IL-10 Producing preCD8α/Clec9A⁺ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection

David Torres, Arnaud Köhler, Sandrine Delbauve, Irina Caminschi, Mireille H. Lahoud, Ken Shortman, Véronique Flamand

PLOS Pathogens: published April 13, 2016 | https://doi.org/10.1371/journal.ppat.1005561

The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence

Delma S. Childers, Ingrida Raziunaite, Gabriela Mol Avelar, Joanna Mackie, Susan Budge, David Stead, Neil A. R. Gow, Megan D. Lenardon, Elizabeth R. Ballou, Donna M. MacCallum, Alistair J. P. Brown

PLOS Pathogens: published April 13, 2016 | https://doi.org/10.1371/journal.ppat.1005566

Entamoeba histolytica Cysteine Proteinase 5 Evokes Mucin Exocytosis from Colonic Goblet Cells via αvβ3 Integrin

Steve Cornick, France Moreau, Kris Chadee

PLOS Pathogens: published April 13, 2016 | https://doi.org/10.1371/journal.ppat.1005579

Mosquito Passage Dramatically Changes var Gene Expression in Controlled Human Plasmodium falciparum Infections

Anna Bachmann, Michaela Petter, Ralf Krumkamp, Meral Esen, Jana Held, Judith A. M. Scholz, Tao Li, B. Kim Lee Sim, Stephen L. Hoffman, Peter G. Kremsner, Benjamin Mordmüller, Michael F. Duffy, Egbert Tannich

PLOS Pathogens: published April 12, 2016 | https://doi.org/10.1371/journal.ppat.1005538

HIV-1 and M-PMV RNA Nuclear Export Elements Program Viral Genomes for Distinct Cytoplasmic Trafficking Behaviors

Ginger M. Pocock, Jordan T. Becker, Chad M. Swanson, Paul Ahlquist, Nathan M. Sherer

PLOS Pathogens: published April 12, 2016 | https://doi.org/10.1371/journal.ppat.1005565

ToxR Antagonizes H-NS Regulation of Horizontally Acquired Genes to Drive Host Colonization

Misha I. Kazi, Aaron R. Conrado, Alexandra R. Mey, Shelley M. Payne, Bryan W. Davies

PLOS Pathogens: published April 12, 2016 | https://doi.org/10.1371/journal.ppat.1005570

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

Rosemarie D. Mason, Hugh C. Welles, Cameron Adams, Bimal K. Chakrabarti, Jason Gorman, Tongqing Zhou, Richard Nguyen, Sijy O’Dell, Sabrina Lusvarghi, Carole A. Bewley, Hui Li, George M. Shaw, Zizhang Sheng, Lawrence Shapiro, Richard Wyatt, Peter D. Kwong, John R. Mascola, Mario Roederer

PLOS Pathogens: published April 11, 2016 | https://doi.org/10.1371/journal.ppat.1005537

Interaction of NCOR/SMRT Repressor Complexes with Papillomavirus E8^E2C Proteins Inhibits Viral Replication

Marcel Dreer, Jasmin Fertey, Saskia van de Poel, Elke Straub, Johannes Madlung, Boris Macek, Thomas Iftner, Frank Stubenrauch

PLOS Pathogens: published April 11, 2016 | https://doi.org/10.1371/journal.ppat.1005556

Revealing the Micro-scale Signature of Endemic Zoonotic Disease Transmission in an African Urban Setting

Hervé Bourhy, Emmanuel Nakouné, Matthew Hall, Pierre Nouvellet, Anthony Lepelletier, Chiraz Talbi, Laurence Watier, Edward C. Holmes, Simon Cauchemez, Philippe Lemey, Christl A. Donnelly, Andrew Rambaut

PLOS Pathogens: published April 8, 2016 | https://doi.org/10.1371/journal.ppat.1005525

Identification of Low- and High-Impact Hemagglutinin Amino Acid Substitutions That Drive Antigenic Drift of Influenza A(H1N1) Viruses

William T. Harvey, Donald J. Benton, Victoria Gregory, James P. J. Hall, Rodney S. Daniels, Trevor Bedford, Daniel T. Haydon, Alan J. Hay, John W. McCauley, Richard Reeve

PLOS Pathogens: published April 8, 2016 | https://doi.org/10.1371/journal.ppat.1005526

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

Jennifer Paijo, Marius Döring, Julia Spanier, Elena Grabski, Mohammed Nooruzzaman, Tobias Schmidt, Gregor Witte, Martin Messerle, Veit Hornung, Volkhard Kaever, Ulrich Kalinke

PLOS Pathogens: published April 8, 2016 | https://doi.org/10.1371/journal.ppat.1005546

The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members

Jana Kamanova, Hui Sun, Maria Lara-Tejero, Jorge E. Galán

PLOS Pathogens: published April 8, 2016 | https://doi.org/10.1371/journal.ppat.1005552

FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection

Sheena C. Kerr, Gregory J. Fischer, Meenal Sinha, Orla McCabe, Jonathan M. Palmer, Tsokyi Choera, Fang Yun Lim, Michaela Wimmerova, Stephen D. Carrington, Shaopeng Yuan, Clifford A. Lowell, Stefan Oscarson, Nancy P. Keller, John V. Fahy

PLOS Pathogens: published April 8, 2016 | https://doi.org/10.1371/journal.ppat.1005555

Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology

Andrés B. Lantos, Giannina Carlevaro, Beatriz Araoz, Pablo Ruiz Diaz, María de los Milagros Camara, Carlos A. Buscaglia, Mariano Bossi, Hai Yu, Xi Chen, Carolyn R. Bertozzi, Juan Mucci, Oscar Campetella

PLOS Pathogens: published April 8, 2016 | https://doi.org/10.1371/journal.ppat.1005559

IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression

José L. Reyes, Maria R. Fernando, Fernando Lopes, Gabriella Leung, Nicole L. Mancini, Chelsea E. Matisz, Arthur Wang, Derek M. McKay

PLOS Pathogens: published April 7, 2016 | https://doi.org/10.1371/journal.ppat.1005481

The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection

Lisa Del Bel Belluz, Riccardo Guidi, Ioannis S. Pateras, Laura Levi, Boris Mihaljevic, Syed Fazle Rouf, Marie Wrande, Marco Candela, Silvia Turroni, Claudia Nastasi, Clarissa Consolandi, Clelia Peano, Toma Tebaldi, Gabriella Viero, Vassilis G. Gorgoulis, Thorbjørn Krejsgaard, Mikael Rhen, Teresa Frisan

PLOS Pathogens: published April 7, 2016 | https://doi.org/10.1371/journal.ppat.1005528

The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons

Michael P. Nicoll, William Hann, Maitreyi Shivkumar, Laura E. R. Harman, Viv Connor, Heather M. Coleman, João T. Proença, Stacey Efstathiou

PLOS Pathogens: published April 7, 2016 | https://doi.org/10.1371/journal.ppat.1005539

Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection

Yuan Li, Sheena Shah-Simpson, Kwame Okrah, A. Trey Belew, Jungmin Choi, Kacey L. Caradonna, Prasad Padmanabhan, David M. Ndegwa, M. Ramzi Temanni, Héctor Corrada Bravo, Najib M. El-Sayed, Barbara A. Burleigh

PLOS Pathogens: published April 5, 2016 | https://doi.org/10.1371/journal.ppat.1005511

Prion Strain Differences in Accumulation of PrPSc on Neurons and Glia Are Associated with Similar Expression Profiles of Neuroinflammatory Genes: Comparison of Three Prion Strains

James A. Carroll, James F. Striebel, Alejandra Rangel, Tyson Woods, Katie Phillips, Karin E. Peterson, Brent Race, Bruce Chesebro

PLOS Pathogens: published April 5, 2016 | https://doi.org/10.1371/journal.ppat.1005551

An Arginine Deprivation Response Pathway Is Induced in Leishmania during Macrophage Invasion

Adele Goldman-Pinkovich, Caitlin Balno, Rona Strasser, Michal Zeituni-Molad, Keren Bendelak, Doris Rentsch, Moshe Ephros, Martin Wiese, Armando Jardim, Peter J. Myler, Dan Zilberstein

PLOS Pathogens: published April 4, 2016 | https://doi.org/10.1371/journal.ppat.1005494

Endoplasmic Reticulum Stress Induced Synthesis of a Novel Viral Factor Mediates Efficient Replication of Genotype-1 Hepatitis E Virus

Vidya P. Nair, Saumya Anang, Chandru Subramani, Abhilasha Madhvi, Karishma Bakshi, Akriti Srivastava, Shalimar, Baibaswata Nayak, Ranjith Kumar CT, Milan Surjit

PLOS Pathogens: published April 1, 2016 | https://doi.org/10.1371/journal.ppat.1005521

Formal Comment

Comment on “Large Bottleneck Size in Cauliflower Mosaic Virus Populations during Host Plant Colonization” by Monsion et al. (2008)

Gaël Thébaud, Yannis Michalakis

PLOS Pathogens: published April 14, 2016 | https://doi.org/10.1371/journal.ppat.1005512

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ABHD5 Taps into Lipid Droplets to Support HCV Production

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