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Table of Contents

September 2017

Drosophila larval salivary glands are comprised of giant polyploid cells, making them an ideal system for sub-cellular distribution and co-localization studies. In this image, an activated and YFP-tagged form of Rab11 was expressed in salivary glands. Rab11 is critical for endocytic recycling, a process through which vesicles carrying junctional components like cadherins are brought near and fuse with the plasma membrane. Only the activated form of Rab11 displays this strong preference for intercellular junctions. The anthrax toxin edema factor (EF) blocks Rab11 function, which weakens the adherens junctions, and promotes edema during infection. Guichard et al.

Image Credit: Annabel Guichard and Ethan Bier, Section of Cell and Developmental Biology, UCSD

Opinion

Zika genomics urgently need standardized and curated reference sequences

Kristof Theys, Pieter Libin, Kai Dallmeier, Andrea-Clemencia Pineda-Peña, Anne-Mieke Vandamme, Lize Cuypers, Ana B. Abecasis

Pearls

Plasmodium heme biosynthesis: To be or not to be essential?

Daniel E. Goldberg, Paul A. Sigala

The microbiome and the hallmarks of cancer

Laura E. Fulbright, Melissa Ellermann, Janelle C. Arthur

Cancer therapy in a microbial bottle: Uncorking the novel biology of the protozoan Toxoplasma gondii

Barbara A. Fox, Kiah L. Butler, Rebekah B. Guevara, David J. Bzik

Genetic and epigenetic engines of diversity in pathogenic microbes

R. Blake Billmyre, Joseph Heitman

Consequences of insecticide resistance on malaria transmission

Haoues Alout, Benjamin Roche, Roch Kounbobr Dabiré, Anna Cohuet

Novel cutting-edge metabolite-based diagnostic tools for aspergillosis

Masha G. Savelieff, Lucia Pappalardo

Reviews

Bacterial toxins: Offensive, defensive, or something else altogether?

Justine K. Rudkin, Rachel M. McLoughlin, Andrew Preston, Ruth C. Massey

Research Articles

Vpma phase variation is important for survival and persistence of Mycoplasma agalactiae in the immunocompetent host

Rohini Chopra-Dewasthaly, Joachim Spergser, Martina Zimmermann, Christine Citti, Wolfgang Jechlinger, Renate Rosengarten

Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs

Kevin Tartour, Xuan-Nhi Nguyen, Romain Appourchaux, Sonia Assil, Véronique Barateau, Louis-Marie Bloyet, Julien Burlaud Gaillard, Marie-Pierre Confort, Beatriz Escudero-Perez, Henri Gruffat, Saw See Hong, Marie Moroso, Olivier Reynard, Stéphanie Reynard, Elodie Decembre, Najate Ftaich, Axel Rossi, Nannan Wu, Frédérick Arnaud, Sylvain Baize, Marlène Dreux, Denis Gerlier, Glaucia Paranhos-Baccala, Viktor Volchkov, Philippe Roingeard, Andrea Cimarelli

An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses

Irene A. I. Hampe, Justin Friedman, Mira Edgerton, Joachim Morschhäuser

Inhibition of melanization by serpin-5 and serpin-9 promotes baculovirus infection in cotton bollworm Helicoverpa armigera

Chuanfei Yuan, Longsheng Xing, Manli Wang, Xi Wang, Mengyi Yin, Qianran Wang, Zhihong Hu, Zhen Zou

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication

Sharon K. Kuss-Duerkop, Juan Wang, Ignacio Mena, Kris White, Giorgi Metreveli, Ramanavelan Sakthivel, Miguel A. Mata, Raquel Muñoz-Moreno, Xiang Chen, Florian Krammer, Michael S. Diamond, Zhijian J. Chen, Adolfo García-Sastre, Beatriz M. A. Fontoura

Malaria-induced interferon-γ drives the expansion of Tbethi atypical memory B cells

Nyamekye Obeng-Adjei, Silvia Portugal, Prasida Holla, Shanping Li, Haewon Sohn, Abhijit Ambegaonkar, Jeff Skinner, Georgina Bowyer, Ogobara K. Doumbo, Boubacar Traore, Susan K. Pierce, Peter D. Crompton

HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways

Fang Guo, Qiong Zhao, Muhammad Sheraz, Junjun Cheng, Yonghe Qi, Qing Su, Andrea Cuconati, Lai Wei, Yanming Du, Wenhui Li, Jinhong Chang, Ju-Tao Guo

Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport

Annabel Guichard, Prashant Jain, Mahtab Moayeri, Ruth Schwartz, Stephen Chin, Lin Zhu, Beatriz Cruz-Moreno, Janet Z. Liu, Bernice Aguilar, Andrew Hollands, Stephen H. Leppla, Victor Nizet, Ethan Bier

A single gp120 residue can affect HIV-1 tropism in macaques

Gregory Q. Del Prete, Brandon F. Keele, Jeannine Fode, Keyur Thummar, Adrienne E. Swanstrom, Anthony Rodriguez, Alice Raymond, Jacob D. Estes, Celia C. LaBranche, David C. Montefiori, Vineet N. KewalRamani, Jeffrey D. Lifson, Paul D. Bieniasz, Theodora Hatziioannou

Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer

Eva Pastille, Annika Frede, Henry J. McSorley, Jessica Gräb, Alexandra Adamczyk, Sebastian Kollenda, Wiebke Hansen, Matthias Epple, Jan Buer, Rick M. Maizels, Robert Klopfleisch, Astrid M. Westendorf

The Kaposi's sarcoma-associated herpesvirus (KSHV) non-structural membrane protein K15 is required for viral lytic replication and may represent a therapeutic target

Bizunesh Abere, Tamrat M. Mamo, Silke Hartmann, Naira Samarina, Elias Hage, Jessica Rückert, Sven-Kevin Hotop, Guntram Büsche, Thomas F. Schulz

A highly conserved amino acid in VP1 regulates maturation of enterovirus 71

Yong-Xin Zhang, Yu-Ming Huang, Quan-Jie Li, Xiao-Yu Li, Yong-Dong Zhou, Fei Guo, Jin-Ming Zhou, Shan Cen

Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation

Nayab Malik, Abhay Kotecha, Sarah Gold, Amin Asfor, Jingshan Ren, Juha T. Huiskonen, Tobias J. Tuthill, Elizabeth E. Fry, David I. Stuart

PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation

Bing-Ru Yan, Lu Zhou, Ming-Ming Hu, Mi Li, Heng Lin, Yan Yang, Yan-Yi Wang, Hong-Bing Shu

The risk of sustained sexual transmission of Zika is underestimated

Antoine Allard, Benjamin M. Althouse, Laurent Hébert-Dufresne, Samuel V. Scarpino

In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication

Matthew D. Marsden, Brian A. Loy, Xiaomeng Wu, Christina M. Ramirez, Adam J. Schrier, Danielle Murray, Akira Shimizu, Steven M. Ryckbosch, Katherine E. Near, Tae-Wook Chun, Paul A. Wender, Jerome A. Zack

In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts

Sayuri Seki, Takushi Nomura, Masako Nishizawa, Hiroyuki Yamamoto, Hiroshi Ishii, Saori Matsuoka, Teiichiro Shiino, Hironori Sato, Kazuta Mizuta, Hiromi Sakawaki, Tomoyuki Miura, Taeko K. Naruse, Akinori Kimura, Tetsuro Matano

T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy

Allison S. Thomas, Kimberley L. Jones, Rajesh T. Gandhi, Deborah K. McMahon, Joshua C. Cyktor, Dora Chan, Szu-Han Huang, Ronald Truong, Alberto Bosque, Amanda B. Macedo, Colin Kovacs, Erika Benko, Joseph J. Eron, Ronald J. Bosch, Christina M. Lalama, Samuel Simmens, Bruce D. Walker, John W. Mellors, R. Brad Jones

HCV-induced autophagosomes are generated via homotypic fusion of phagophores that mediate HCV RNA replication

Linya Wang, Ja Yeon Kim, Helene Minyi Liu, Michael M. C. Lai, Jing-hsiung James Ou

Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis

Jorge Domínguez-Andrés, Rob J. W. Arts, Rob ter Horst, Mark S. Gresnigt, Sanne P. Smeekens, Jacqueline M. Ratter, Ekta Lachmandas, Lily Boutens, Frank L. van de Veerdonk, Leo A. B. Joosten, Richard A. Notebaart, Carlos Ardavín, Mihai G. Netea

Hypoxia-inducible factor-1 alpha as a therapeutic target for primary effusion lymphoma

Prabha Shrestha, David A. Davis, Ravindra P. Veeranna, Robert F. Carey, Coralie Viollet, Robert Yarchoan

Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites

Christine S. Hopp, Brandy L. Bennett, Satish Mishra, Christine Lehmann, Kirsten K. Hanson, Jing-wen Lin, Kimberly Rousseau, Filomena A. Carvalho, Wouter A. van der Linden, Nuno C. Santos, Matthew Bogyo, Shahid M. Khan, Volker Heussler, Photini Sinnis

A novel mechanism of antibody-mediated enhancement of flavivirus infection

Denise Haslwanter, Dieter Blaas, Franz X. Heinz, Karin Stiasny

Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates

Bradley R. Groveman, Gregory J. Raymond, Katrina J. Campbell, Brent Race, Lynne D. Raymond, Andrew G. Hughson, Christina D. Orrú, Allison Kraus, Katie Phillips, Byron Caughey

Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection

Yuxuan Fu, Li Zhang, Fang Zhang, Ting Tang, Qi Zhou, Chunhong Feng, Yu Jin, Zhiwei Wu

IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways

Leila Sawada, Yoshiko Nagano, Atsuhiko Hasegawa, Hikari Kanai, Kai Nogami, Sayaka Ito, Tomoo Sato, Yoshihisa Yamano, Yuetsu Tanaka, Takao Masuda, Mari Kannagi

Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells

Derek B. Danahy, Scott M. Anthony, Isaac J. Jensen, Stacey M. Hartwig, Qiang Shan, Hai-Hui Xue, John T. Harty, Thomas S. Griffith, Vladimir P. Badovinac

Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA

Aline C. Habison, Marta Pires de Miranda, Chantal Beauchemin, Min Tan, Sofia A. Cerqueira, Bruno Correia, Rajesh Ponnusamy, Edward J. Usherwood, Colin E. McVey, J. Pedro Simas, Kenneth M. Kaye

Different rates of spontaneous mutation of chloroplastic and nuclear viroids as determined by high-fidelity ultra-deep sequencing

Amparo López-Carrasco, Cristina Ballesteros, Vicente Sentandreu, Sonia Delgado, Selma Gago-Zachert, Ricardo Flores, Rafael Sanjuán

Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response

Viktoriya Dubrovskaya, Javier Guenaga, Natalia de Val, Richard Wilson, Yu Feng, Arlette Movsesyan, Gunilla B. Karlsson Hedestam, Andrew B. Ward, Richard T. Wyatt

TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses

Qing Yang, Tian-Tian Liu, Heng Lin, Man Zhang, Jin Wei, Wei-Wei Luo, Yun-Hong Hu, Bo Zhong, Ming-Ming Hu, Hong-Bing Shu

HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis

Akil Hammami, Belma Melda Abidin, Tania Charpentier, Aymeric Fabié, Annie-Pier Duguay, Krista M. Heinonen, Simona Stäger

Convergent evolution involving dimeric and trimeric dUTPases in pathogenicity island mobilization

Jorge Donderis, Janine Bowring, Elisa Maiques, J. Rafael Ciges-Tomas, Christian Alite, Iltyar Mehmedov, María Angeles Tormo-Mas, José R. Penadés, Alberto Marina

Reversible unfolding of infectious prion assemblies reveals the existence of an oligomeric elementary brick

Angélique Igel-Egalon, Mohammed Moudjou, Davy Martin, Alexandra Busley, Tina Knäpple, Laetitia Herzog, Fabienne Reine, Nad’a Lepejova, Charles-Adrien Richard, Vincent Béringue, Human Rezaei

Staphylococcal enterotoxin-like X (SElX) is a unique superantigen with functional features of two major families of staphylococcal virulence factors

Ries J. Langley, Yi Tian Ting, Fiona Clow, Paul G. Young, Fiona J. Radcliff, Jeong Min Choi, Richard P. Sequeira, Silva Holtfreter, Heather Baker, John D. Fraser

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