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Table of Contents

November 2017

This image shows a common vole (Microtus arvalis) from northwest Spain. Populations of this species typically experience boom-and-bust abundance dynamics that generate epizootic outbreaks of tularemia in the region. Molecular analyses of infection prevalence have demonstrated recently the role of common voles as amplification and spill over agents of this zoonotic disease. Fluctuations in the abundance of wild herbivorous mammals play a key role in the epidemiology of tularemia across Europe. Luque-Larena et al.

Image Credit: Juan José Luque-Larena

Pearls

Public health risks from subclinical variant CJD

Abigail B. Diack, Robert G. Will, Jean C. Manson

Irruptive mammal host populations shape tularemia epidemiology

Juan J. Luque-Larena, François Mougeot, Beatriz Arroyo, Mª Dolors Vidal, Ruth Rodríguez-Pastor, Raquel Escudero, Pedro Anda, Xavier Lambin

How alkalinization drives fungal pathogenicity

Tânia R. Fernandes, David Segorbe, Dov Prusky, Antonio Di Pietro

Chronic wasting disease: Emerging prions and their potential risk

Samia Hannaoui, Hermann M. Schatzl, Sabine Gilch

Research Matters

Got herpes? (Yep, you probably do!)

Eain A. Murphy

Research Articles

Listeria monocytogenes switches from dissemination to persistence by adopting a vacuolar lifestyle in epithelial cells

Mounia Kortebi, Eliane Milohanic, Gabriel Mitchell, Christine Péchoux, Marie-Christine Prevost, Pascale Cossart, Hélène Bierne

The interplay of UV and cutaneous papillomavirus infection in skin cancer development

Daniel Hasche, Sonja Stephan, Ilona Braspenning-Wesch, Julita Mikulec, Martina Niebler, Hermann-Josef Gröne, Christa Flechtenmacher, Baki Akgül, Frank Rösl, Sabrina E. Vinzón

Experience-dependent olfactory behaviors of the parasitic nematode Heligmosomoides polygyrus

Felicitas Ruiz, Michelle L. Castelletto, Spencer S. Gang, Elissa A. Hallem

Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus

Ben Hu, Lei-Ping Zeng, Xing-Lou Yang, Xing-Yi Ge, Wei Zhang, Bei Li, Jia-Zheng Xie, Xu-Rui Shen, Yun-Zhi Zhang, Ning Wang, Dong-Sheng Luo, Xiao-Shuang Zheng, Mei-Niang Wang, Peter Daszak, Lin-Fa Wang, Jie Cui, Zheng-Li Shi

Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells

Eloise J. O’Donoghue, Natalie Sirisaengtaksin, Douglas F. Browning, Ewa Bielska, Mohammed Hadis, Francisco Fernandez-Trillo, Luke Alderwick, Sara Jabbari, Anne Marie Krachler

RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production

Joris K. Sprokholt, Tanja M. Kaptein, John L. van Hamme, Ronald J. Overmars, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek

Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo

Rie Furuta, Jun-ichirou Yasunaga, Michi Miura, Kenji Sugata, Akatsuki Saito, Hirofumi Akari, Takaharu Ueno, Norihiro Takenouchi, Jun-ichi Fujisawa, Ki-Ryang Koh, Yusuke Higuchi, Mohamed Mahgoub, Masakazu Shimizu, Fumihiko Matsuda, Anat Melamed, Charles R. Bangham, Masao Matsuoka

H1N1 influenza virus infection results in adverse pregnancy outcomes by disrupting tissue-specific hormonal regulation

Elizabeth Q. Littauer, E. Stein Esser, Olivia Q. Antao, Elena V. Vassilieva, Richard W. Compans, Ioanna Skountzou

Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation

Florence Levillain, Yannick Poquet, Ludovic Mallet, Serge Mazères, Michael Marceau, Roland Brosch, Franz-Christoph Bange, Philip Supply, Axel Magalon, Olivier Neyrolles

Modulation of host central carbon metabolism and in situ glucose uptake by intracellular Trypanosoma cruzi amastigotes

Sheena Shah-Simpson, Gaelle Lentini, Peter C. Dumoulin, Barbara A. Burleigh

Protection of mice deficient in mature B cells from West Nile virus infection by passive and active immunization

Daniela Giordano, Kevin E. Draves, Lucy B. Young, Kelsey Roe, Marianne A. Bryan, Christiane Dresch, Justin M. Richner, Michael S. Diamond, Michael Gale Jr, Edward A. Clark

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

Despoina Goniotaki, Asvin K. K. Lakkaraju, Amulya N. Shrivastava, Pamela Bakirci, Silvia Sorce, Assunta Senatore, Rajlakshmi Marpakwar, Simone Hornemann, Fabrizio Gasparini, Antoine Triller, Adriano Aguzzi

The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissues

Xiang-Yang Xue, Vladimir Majerciak, Aayushi Uberoi, Bong-Hyun Kim, Deanna Gotte, Xiongfong Chen, Maggie Cam, Paul F. Lambert, Zhi-Ming Zheng

Vaccine-elicited memory CD4+ T cell expansion is impaired in the lungs during tuberculosis

Stephen M. Carpenter, Jason D. Yang, Jinhee Lee, Palmira Barreira-Silva, Samuel M. Behar

Interleukin-36γ and IL-36 receptor signaling mediate impaired host immunity and lung injury in cytotoxic Pseudomonas aeruginosa pulmonary infection: Role of prostaglandin E2

Tetsuji Aoyagi, Michael W. Newstead, Xianying Zeng, Yuta Nanjo, Marc Peters-Golden, Mitsuo Kaku, Theodore J. Standiford

Flotillin scaffold activity contributes to type VII secretion system assembly in Staphylococcus aureus

Benjamin Mielich-Süss, Rabea M. Wagner, Nicole Mietrach, Tobias Hertlein, Gabriella Marincola, Knut Ohlsen, Sebastian Geibel, Daniel Lopez

Subtle variation within conserved effector operon gene products contributes to T6SS-mediated killing and immunity

Christopher J. Alteri, Stephanie D. Himpsl, Kevin Zhu, Haley L. Hershey, Ninette Musili, Jessa E. Miller, Harry L. T. Mobley

Estimating virus effective population size and selection without neutral markers

Elsa Rousseau, Benoît Moury, Ludovic Mailleret, Rachid Senoussi, Alain Palloix, Vincent Simon, Sophie Valière, Frédéric Grognard, Frédéric Fabre

iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA

Wei-Wei Luo, Shu Li, Chen Li, Zhou-Qin Zheng, Pan Cao, Zhen Tong, Huan Lian, Su-Yun Wang, Hong-Bing Shu, Yan-Yi Wang

Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease

Thomas J. Scriba, Adam Penn-Nicholson, Smitha Shankar, Tom Hraha, Ethan G. Thompson, David Sterling, Elisa Nemes, Fatoumatta Darboe, Sara Suliman, Lynn M. Amon, Hassan Mahomed, Mzwandile Erasmus, Wendy Whatney, John L. Johnson, W. Henry Boom, Mark Hatherill, Joe Valvo, Mary Ann De Groote, Urs A. Ochsner, Alan Aderem, Willem A. Hanekom, Daniel E. Zak, other members of the ACS cohort study team

Preconceptual Zika virus asymptomatic infection protects against secondary prenatal infection

Lucien H. Turner, Jeremy M. Kinder, Adrienne Wilburn, Rahul J. D’Mello, Makayla R. Braunlin, Tony T. Jiang, Giang Pham, Sing Sing Way

Structural basis of glycan specificity of P[19] VP8*: Implications for rotavirus zoonosis and evolution

Yang Liu, Shenyuan Xu, Andrew L. Woodruff, Ming Xia, Ming Tan, Michael A. Kennedy, Xi Jiang

GDSL lipases modulate immunity through lipid homeostasis in rice

Mingjun Gao, Xin Yin, Weibing Yang, Sin Man Lam, Xiaohong Tong, Jiyun Liu, Xin Wang, Qun Li, Guanghou Shui, Zuhua He

Unraveling the key to the resistance of canids to prion diseases

Natalia Fernández-Borges, Beatriz Parra, Enric Vidal, Hasier Eraña, Manuel A. Sánchez-Martín, Jorge de Castro, Saioa R. Elezgarai, Martí Pumarola, Tomás Mayoral, Joaquín Castilla

Autophagy pathway induced by a plant virus facilitates viral spread and transmission by its insect vector

Yong Chen, Qian Chen, Manman Li, Qianzhuo Mao, Hongyan Chen, Wei Wu, Dongsheng Jia, Taiyun Wei

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner

Run Fang, Qifei Jiang, Xiang Zhou, Chenguang Wang, Yukun Guan, Jianli Tao, Jianzhong Xi, Ji-Ming Feng, Zhengfan Jiang

Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components

Dustin R. Glasner, Kalani Ratnasiri, Henry Puerta-Guardo, Diego A. Espinosa, P. Robert Beatty, Eva Harris

A mobile loop near the active site acts as a switch between the dual activities of a viral protease/deubiquitinase

Isabelle Jupin, Maya Ayach, Lucile Jomat, Sonia Fieulaine, Stéphane Bressanelli

Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection

Masa Ivin, Amy Dumigan, Filipe N. de Vasconcelos, Florian Ebner, Martina Borroni, Anoop Kavirayani, Kornelia N. Przybyszewska, Rebecca J. Ingram, Stefan Lienenklaus, Ulrich Kalinke, Dagmar Stoiber, Jose A. Bengoechea, Pavel Kovarik

Fitness cost of reassortment in human influenza

Mara Villa, Michael Lässig

Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1

Romel D. Mackelprang, Michael J. Bamshad, Jessica X. Chong, Xuanlin Hou, Kati J. Buckingham, Kathryn Shively, Guy deBruyn, Nelly R. Mugo, James I. Mullins, M. Juliana McElrath, Jared M. Baeten, Connie Celum, Mary J. Emond, Jairam R. Lingappa, for the Partners in Prevention HSV/HIV Transmission Study and the Partners PrEP Study Teams

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