Therapeutic perspectives for prion diseases in humans and animals

Rebeca Benavente, Rodrigo Morales

PLOS Pathogens: published December 10, 2024 | https://doi.org/10.1371/journal.ppat.1012676

Is metabolic generalism the Breakfast of Champions for pathogenic Candida species?

Delma S. Childers, Jane Usher

PLOS Pathogens: published December 11, 2024 | https://doi.org/10.1371/journal.ppat.1012752

The 2 faces of plant SUMOylation against viruses

Blanca Sabarit, Eduardo R. Bejarano

PLOS Pathogens: published December 17, 2024 | https://doi.org/10.1371/journal.ppat.1012701

Climate change and Vibrio vulnificus dynamics: A blueprint for infectious diseases

Jane M. Jayakumar, Jaime Martinez-Urtaza, Kyle D. Brumfield, Antarpreet S. Jutla, Rita R. Colwell, Otto X. Cordero, Salvador Almagro-Moreno

PLOS Pathogens: published December 16, 2024 | https://doi.org/10.1371/journal.ppat.1012767

Chickpea NCR13 disulfide cross-linking variants exhibit profound differences in antifungal activity and modes of action

James Godwin, Arnaud Thierry Djami-Tchatchou, Siva L. S. Velivelli, Meenakshi Tetorya, Raviraj Kalunke, Ambika Pokhrel, Mowei Zhou, Garry W. Buchko, Kirk J. Czymmek, Dilip M. Shah

PLOS Pathogens: published December 2, 2024 | https://doi.org/10.1371/journal.ppat.1012745

A zebrafish-based in vivo model of Zika virus infection unveils alterations of the glutamatergic neuronal development and NS4A as a key viral determinant of neuropathogenesis

Aïssatou Aïcha Sow, Priyanka Jamadagni, Pietro Scaturro, Shunmoogum A. Patten, Laurent Chatel-Chaix

PLOS Pathogens: published December 2, 2024 | https://doi.org/10.1371/journal.ppat.1012756

Serotype switching in Pseudomonas aeruginosa ST111 enhances adhesion and virulence

Mikkel Anbo, Mahbuba Akter Lubna, Dina A. Moustafa, Telmo O. Paiva, Laura Serioli, Kinga Zor, Claus Sternberg, Katy Jeannot, Oana Ciofu, Yves F. Dufrêne, Joanna B. Goldberg, Lars Jelsbak

PLOS Pathogens: published December 2, 2024 | https://doi.org/10.1371/journal.ppat.1012221

Newcastle disease virus infection induces parthanatos in tumor cells via calcium waves

Yang Qu, Siyuan Wang, Hui Jiang, Ying Liao, Xusheng Qiu, Lei Tan, Cuiping Song, Venugopal Nair, Zengqi Yang, Yingjie Sun, Chan Ding

PLOS Pathogens: published December 2, 2024 | https://doi.org/10.1371/journal.ppat.1012737

Molecular characterization of the permanent outer-inner membrane contact site of the mitochondrial genome segregation complex in trypanosomes

Philip Stettler, Bernd Schimanski, Salome Aeschlimann, André Schneider

PLOS Pathogens: published December 2, 2024 | https://doi.org/10.1371/journal.ppat.1012635

Vibrio cholerae RbmB is an α-1,4-polysaccharide lyase with biofilm-disrupting activity against Vibrio polysaccharide (VPS)

Ranjuna Weerasekera, Alexis Moreau, Xin Huang, Kee-Myoung Nam, Alexander J. Hinbest, Yun Huynh, Xinyu Liu, Christopher Ashwood, Lauren E. Pepi, Eric Paulson, Lynette Cegelski, Jing Yan, Rich Olson

PLOS Pathogens: published December 2, 2024 | https://doi.org/10.1371/journal.ppat.1012750

SARS-CoV-2 Omicron variations reveal mechanisms controlling cell entry dynamics and antibody neutralization

Enya Qing, Julisa Salgado, Alexandria Wilcox, Tom Gallagher

PLOS Pathogens: published December 2, 2024 | https://doi.org/10.1371/journal.ppat.1012757

Flaviviruses induce ER-specific remodelling of protein synthesis

Ho Him Wong, Dorian Richard Kenneth Crudgington, Lewis Siu, Sumana Sanyal

PLOS Pathogens: published December 2, 2024 | https://doi.org/10.1371/journal.ppat.1012766

Interferon epsilon is produced in the testis and protects the male reproductive tract against virus infection, inflammation and damage

Rukmali Wijayarathna, Eveline D. de Geus, Rosemary Genovese, Linden J. Gearing, Georgie Wray-McCann, Rajini Sreenivasan, Hiba Hasan, Monika Fijak, Peter Stanton, Daniela Fietz, Adrian Pilatz, Hans-Christian Schuppe, Michelle D. Tate, Paul J. Hertzog, Mark P. Hedger

PLOS Pathogens: published December 2, 2024 | https://doi.org/10.1371/journal.ppat.1012702

Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein

Xavier Carnec, Virginie Borges-Cardoso, Stéphanie Reynard, Heinrich Kowalski, Jean-Charles Gaillard, Mathieu Mateo, Jean Armengaud, Sylvain Baize

PLOS Pathogens: published December 3, 2024 | https://doi.org/10.1371/journal.ppat.1012715

Cellular sialoglycans are differentially required for endosomal and cell-surface entry of SARS-CoV-2 in lung cell lines

Kimberley C. Siwak, Emmanuelle V. LeBlanc, Heidi M. Scott, Youjin Kim, Isabella Pellizzari-Delano, Alice M. Ball, Nigel J. Temperton, Chantelle J. Capicciotti, Che C. Colpitts

PLOS Pathogens: published December 3, 2024 | https://doi.org/10.1371/journal.ppat.1012365

Receptor binding and structural basis of raccoon dog ACE2 binding to SARS-CoV-2 prototype and its variants

Chunliang Luo, Linjie Li, Yuhang Gu, Hangchuan Zhang, Zepeng Xu, Junqing Sun, Kaiyuan Shi, Sufang Ma, Wen-Xia Tian, Kefang Liu, George F. Gao

PLOS Pathogens: published December 5, 2024 | https://doi.org/10.1371/journal.ppat.1012713

Insights into the structural changes that trigger receptor binding upon proteolytic activation of Bacillus thuringiensis Vip3Aa insecticidal protein

Oscar Infante, Isabel Gómez, Angel E. Pélaez-Aguilar, Luis A. Verduzco-Rosas, Rosalina García-Suárez, Blanca I. García-Gómez, Zeyu Wang, Jie Zhang, Adan Guerrero, Alejandra Bravo, Mario Soberón

PLOS Pathogens: published December 5, 2024 | https://doi.org/10.1371/journal.ppat.1012765

Single-cell analysis reveals host S phase drives large T antigen expression during BK polyomavirus infection

Jason M. Needham, Sarah E. Perritt, Sunnie R. Thompson

PLOS Pathogens: published December 5, 2024 | https://doi.org/10.1371/journal.ppat.1012663

SUMO-targeted Ubiquitin Ligases as crucial mediators of protein homeostasis in Candida glabrata

Dipika Gupta, Renu Shukla, Krishnaveni Mishra

PLOS Pathogens: published December 6, 2024 | https://doi.org/10.1371/journal.ppat.1012742

A-synuclein prion strains differentially adapt after passage in mice

Sara A. M. Holec, Chase R. Khedmatgozar, Shelbe J. Schure, Tiffany Pham, Amanda L. Woerman

PLOS Pathogens: published December 6, 2024 | https://doi.org/10.1371/journal.ppat.1012746

TNF-α exacerbates SARS-CoV-2 infection by stimulating CXCL1 production from macrophages

Moe Kobayashi, Nene Kobayashi, Kyoka Deguchi, Seira Omori, Minami Nagai, Ryutaro Fukui, Isaiah Song, Shinji Fukuda, Kensuke Miyake, Takeshi Ichinohe

PLOS Pathogens: published December 9, 2024 | https://doi.org/10.1371/journal.ppat.1012776

Skin as outermost immune organ of vertebrates that elicits robust early immune responses after immunization with glycoprotein of spring viraemia of carp virus

Zhao Zhao, Liang Zhao, Xue-Feng Wei, Yi-Jun Jia, Bin Zhu

PLOS Pathogens: published December 9, 2024 | https://doi.org/10.1371/journal.ppat.1012744

Mosquito-independent milk-associated transmission of zoonotic Wesselsbron virus in sheep

Marta Zimoch, Llorenç Grau-Roma, Matthias Liniger, Noelle Donzé, Aurélie Godel, Damián Escribano, Bettina Salome Trüeb, Paraskevi Pramateftaki, Sergi Torres-Puig, José Joaqín Cerón, Volker Thiel, Jörg Jores, Artur Summerfield, Nicolas Ruggli, Charaf Benarafa, Obdulio García-Nicolás

PLOS Pathogens: published December 9, 2024 | https://doi.org/10.1371/journal.ppat.1012751

Structural characterization of the full-length Hantaan virus polymerase

Jeremy R. Keown, Loïc Carrique, Benjamin E. Nilsson-Payant, Ervin Fodor, Jonathan M. Grimes

PLOS Pathogens: published December 9, 2024 | https://doi.org/10.1371/journal.ppat.1012781

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo

Stanley C. Xie, Chia-Wei Tai, Craig J. Morton, Liting Ma, Shih-Chung Huang, Sergio Wittlin, Yawei Du, Yongbo Hu, Con Dogovski, Mina Salimimarand, Robert Griffin, Dylan England, Elisa de la Cruz, Ioanna Deni, Tomas Yeo, Anna Y. Burkhard, Josefine Striepen, Kyra A. Schindler, Benigno Crespo, Francisco J. Gamo, Yogesh Khandokar, Craig A. Hutton, Tayla Rabie, Lyn-Marié Birkholtz, Mufuliat T. Famodimu, Michael J. Delves, Judith Bolsher, Karin M. J. Koolen, Rianne van der Laak, Anna C. C. Aguiar, Dhelio B. Pereira, Rafael V. C. Guido, Darren J. Creek, David A. Fidock, Lawrence R. Dick, Stephen L. Brand, Alexandra E. Gould, Steven Langston, Michael D. W. Griffin, Leann Tilley

PLOS Pathogens: published December 9, 2024 | https://doi.org/10.1371/journal.ppat.1012429

Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness

Eleni Bilev, Nicole Wild, Pouria Momayyezi, Benedetta Maria Sala, Renhua Sun, Tatyana Sandalova, Nicole Marquardt, Hans-Gustaf Ljunggren, Adnane Achour, Quirin Hammer

PLOS Pathogens: published December 9, 2024 | https://doi.org/10.1371/journal.ppat.1012755

Fatal Lassa fever in cynomolgus monkeys is associated with systemic viral dissemination and inflammation

Jimmy Hortion, Emeline Perthame, Blaise Lafoux, Laura Soyer, Stéphanie Reynard, Alexandra Journeaux, Clara Germain, Hélène Lopez-Maestre, Natalia Pietrosemoli, Nicolas Baillet, Séverine Croze, Catherine Rey, Catherine Legras-Lachuer, Sylvain Baize

PLOS Pathogens: published December 9, 2024 | https://doi.org/10.1371/journal.ppat.1012768

H5 subtype avian influenza virus induces Golgi apparatus stress response via TFE3 pathway to promote virus replication

Yuncong Yin, Xianjin Kan, Xinyu Miao, Yingjie Sun, Sujuan Chen, Tao Qin, Chan Ding, Daxin Peng, Xiufan Liu

PLOS Pathogens: published December 9, 2024 | https://doi.org/10.1371/journal.ppat.1012748

Polyfunctionality and breadth of HIV-1 antibodies are associated with delayed disease progression

Marloes Grobben, Margreet Bakker, Angela I. Schriek, Liesbeth J.J. Levels, Jeffrey C. Umotoy, Khadija Tejjani, Mariëlle J. van Breemen, Ryan N. Lin, Steven W. de Taeye, Gabriel Ozorowski, Neeltje A. Kootstra, Andrew B. Ward, Stephen J. Kent, P. Mark Hogarth, Bruce D. Wines, Rogier W. Sanders, Amy W. Chung, Marit J. van Gils

PLOS Pathogens: published December 11, 2024 | https://doi.org/10.1371/journal.ppat.1012739

Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34⁺ hematopoietic progenitor cells and humanized mice

Nicole L. Diggins, Andrew H. Pham, Jennifer Mitchell, Christopher J. Parkins, Luke Slind, Rebekah Turner, Byeong-Jae Lee, Andrew D. Yurochko, Patrizia Caposio, Jay A. Nelson, Meaghan H. Hancock

PLOS Pathogens: published December 11, 2024 | https://doi.org/10.1371/journal.ppat.1012285

Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus

Hannah Ochner, Jan Böhning, Zhexin Wang, Abul K. Tarafder, Ido Caspy, Tanmay A. M. Bharat

PLOS Pathogens: published December 12, 2024 | https://doi.org/10.1371/journal.ppat.1012773

Deep phosphoproteomics of Klebsiella pneumoniae reveals HipA-mediated tolerance to ciprofloxacin

Payal Nashier, Isabell Samp, Marvin Adler, Fiona Ebner, Lisa Thai Lê, Marc Göppel, Carsten Jers, Ivan Mijakovic, Sandra Schwarz, Boris Macek

PLOS Pathogens: published December 12, 2024 | https://doi.org/10.1371/journal.ppat.1012759

Seasonal influenza a virus lineages exhibit divergent abilities to antagonize interferon induction and signaling

Joel Rivera-Cardona, Neeha Kakuturu, Elizabeth F. Rowland, Qi Wen Teo, Elizabeth A. Thayer, Timothy J. C. Tan, Jiayi Sun, Collin Kieffer, Nicholas C. Wu, Christopher B. Brooke

PLOS Pathogens: published December 12, 2024 | https://doi.org/10.1371/journal.ppat.1012727

Sniffer restricts arboviral brain infections by regulating ROS levels and protecting blood-brain barrier integrity in Drosophila and mosquitoes

Rui Hu, Mengzhu Li, Shulin Chen, Man Wang, Xinjun Tao, Yihan Zhu, Huan Yan, Yuan Liu

PLOS Pathogens: published December 16, 2024 | https://doi.org/10.1371/journal.ppat.1012797

Activation of the tick Toll pathway to control infection of Ixodes ricinus by the apicomplexan parasite Babesia microti

Marie Jalovecka, Laurence Malandrin, Veronika Urbanova, Sazzad Mahmood, Pavla Snebergerova, Miriama Peklanska, Veronika Pavlasova, Radek Sima, Petr Kopacek, Jan Perner, Ondrej Hajdusek

PLOS Pathogens: published December 16, 2024 | https://doi.org/10.1371/journal.ppat.1012743

Zinc homeostasis regulates caspase activity and inflammasome activation

Xiao Gong, Weidi Gu, Shuo Fu, Gonglu Zou, Zhengfan Jiang

PLOS Pathogens: published December 17, 2024 | https://doi.org/10.1371/journal.ppat.1012805

A previously unidentified circRNA inhibits virus replication by regulating the miR-24-3p/KEAP1 axis

Haimin Li, Liuyang Du, Juan Li, Yanming Huang, Chenhe Lu, Tingjuan Deng, Yan Yan, Yulan Jin, Wei Wu, Jinyan Gu, Jiyong Zhou

PLOS Pathogens: published December 17, 2024 | https://doi.org/10.1371/journal.ppat.1012712

Transcriptome analysis of two isolates of the tomato pathogen Cladosporium fulvum, uncovers genome-wide patterns of alternative splicing during a host infection cycle

Alex Z. Zaccaron, Li-Hung Chen, Ioannis Stergiopoulos

PLOS Pathogens: published December 18, 2024 | https://doi.org/10.1371/journal.ppat.1012791

APEX-based proximity labeling in Plasmodium identifies a membrane protein with dual functions during mosquito infection

Jessica Kehrer, Emma Pietsch, Dominik Ricken, Léanne Strauss, Julia M. Heinze, Tim Gilberger, Friedrich Frischknecht

PLOS Pathogens: published December 18, 2024 | https://doi.org/10.1371/journal.ppat.1012788

Fructose-1,6-diphosphate inhibits viral replication by promoting the lysosomal degradation of HMGB1 and blocking the binding of HMGB1 to the viral genome

Penghui Hu, Huiyi Li, Zemin Ji, Weijia Jing, Zihan Li, Sujun Yu, Xiao Shan, Yan Cui, Baochen Wang, Hongyuan Dong, Yanzhao Zhou, Zhe Wang, Hui Xiong, Xiaomei Zhang, Hui-chieh Li, Jinrong Wang, Jiuzhou Tang, Ting Wang, Keliang Xie, Yuping Liu, Haizhen Zhu, Qiujing Yu

PLOS Pathogens: published December 18, 2024 | https://doi.org/10.1371/journal.ppat.1012782

Immunopeptidomic MHC-I profiling and immunogenicity testing identifies Tcj2 as a new Chagas disease mRNA vaccine candidate

Leroy Versteeg, Rakesh Adhikari, Gonteria Robinson, Jungsoon Lee, Junfei Wei, Nelufa Islam, Brian Keegan, William K. Russell, Cristina Poveda, Maria Jose Villar, Kathryn Jones, Maria Elena Bottazzi, Peter Hotez, Edwin Tijhaar, Jeroen Pollet

PLOS Pathogens: published December 18, 2024 | https://doi.org/10.1371/journal.ppat.1012764

Macrophage MST1 protects against schistosomiasis-induced liver fibrosis by promoting the PPARγ-CD36 pathway and suppressing NF-κB signaling

Jianyang Li, Xinyuan Cai, Yan Yang, Yulin Mao, Lin Ding, Qian Xue, Xunhao Hu, Yan Huang, Cong Sui, Yuxia Zhang

PLOS Pathogens: published December 19, 2024 | https://doi.org/10.1371/journal.ppat.1012790

Structural insights into Semiliki forest virus receptor binding modes indicate novel mechanism of virus endocytosis

Decheng Yang, Nan Wang, Bingchen Du, Zhenzhao Sun, Shida Wang, Xijun He, Jinyue Wang, Tao Zheng, Yutao Chen, Xiangxi Wang, Jingfei Wang

PLOS Pathogens: published December 20, 2024 | https://doi.org/10.1371/journal.ppat.1012770

The pseudoknot region and poly-(C) tract comprise an essential RNA packaging signal for assembly of foot-and-mouth disease virus

Chris Neil, Joseph Newman, Nicola J. Stonehouse, David J. Rowlands, Graham J. Belsham, Tobias J. Tuthill

PLOS Pathogens: published December 23, 2024 | https://doi.org/10.1371/journal.ppat.1012283

Immunodominant extracellular loops of Treponema pallidum FadL outer membrane proteins elicit antibodies with opsonic and growth-inhibitory activities

Kristina N. Delgado, Melissa J. Caimano, Isabel C. Orbe, Crystal F. Vicente, Carson J. La Vake, André A. Grassmann, M. Anthony Moody, Justin D. Radolf, Kelly L. Hawley

PLOS Pathogens: published December 23, 2024 | https://doi.org/10.1371/journal.ppat.1012443

Systematic assessment of COVID-19 host genetics using whole genome sequencing data

Axel Schmidt, Nicolas Casadei, Fabian Brand, German Demidov, Elaheh Vojgani, Ayda Abolhassani, Rana Aldisi, Guillaume Butler-Laporte, DeCOI host genetics group, T. Madhusankha Alawathurage, Max Augustin, Robert Bals, Carla Bellinghausen, Marc Moritz Berger, Michael Bitzer, Christian Bode, Jannik Boos, Thorsten Brenner, Oliver A. Cornely, Thomas Eggermann, Johanna Erber, Torsten Feldt, Christian Fuchsberger, Julien Gagneur, Siri Göpel, Tobias Haack, Helene Häberle, Frank Hanses, Julia Heggemann, Ute Hehr, Johannes C. Hellmuth, Christian Herr, Anke Hinney, Per Hoffmann, Thomas Illig, Björn-Erik Ole Jensen, Verena Keitel, Sarah Kim-Hellmuth, Philipp Koehler, Ingo Kurth, Anna-Lisa Lanz, Eicke Latz, Clara Lehmann, Tom Luedde, Carlo Maj, Michael Mian, Abigail Miller, Maximilian Muenchhoff, Isabell Pink, Ulrike Protzer, Hana Rohn, Jan Rybniker, Federica Scaggiante, Anna Schaffeldt, Clemens Scherer, Maximilian Schieck, Susanne V. Schmidt, Philipp Schommers, Christoph D. Spinner, Maria J. G. T. Vehreschild, Thirumalaisamy P. Velavan, Sonja Volland, Sibylle Wilfling, Christof Winter, J. Brent Richards, DeCOI, André Heimbach, Kerstin Becker, Stephan Ossowski, Joachim L. Schultze, Peter Nürnberg, Markus M. Nöthen, Susanne Motameny, Michael Nothnagel, Olaf Riess, Eva C. Schulte, Kerstin U. Ludwig

PLOS Pathogens: published December 23, 2024 | https://doi.org/10.1371/journal.ppat.1012786

Stress contingent changes in Hog1 pathway architecture and regulation in Candida albicans

Alison M. Day, Min Cao, Alessandra da Silva Dantas, Olga Ianieva, Carmen Herrero-de-Dios, Alistair J. P. Brown, Janet Quinn

PLOS Pathogens: published December 23, 2024 | https://doi.org/10.1371/journal.ppat.1012314

Discovery of Nanosota-EB1 and -EB2 as Novel Nanobody Inhibitors Against Ebola Virus Infection

Fan Bu, Gang Ye, Kimberly Morsheimer, Alise Mendoza, Hailey Turner-Hubbard, Morgan Herbst, Benjamin Spiller, Brian E. Wadzinski, Brett Eaton, Manu Anantpadma, Ge Yang, Bin Liu, Robert Davey, Fang Li

PLOS Pathogens: published December 23, 2024 | https://doi.org/10.1371/journal.ppat.1012817

The SpxA1-TenA toxin-antitoxin system regulates epigenetic variations of Streptococcus pneumoniae by targeting protein synthesis

Shaomeng Wang, Xiu-Yuan Li, Mengran Zhu, Haiteng Deng, Juanjuan Wang, Jing-Ren Zhang

PLOS Pathogens: published December 26, 2024 | https://doi.org/10.1371/journal.ppat.1012801

Mechanisms of sterilizing immunity provided by an HIV-1 neutralizing antibody against mucosal infection

Elie Richel, Arne Cordsmeier, Larissa Bauer, Kirsten Fraedrich, Ramona Vestweber, Berit Roshani, Nicole Stolte-Leeb, Armin Ensser, Christiane Stahl-Hennig, Klaus Überla

PLOS Pathogens: published December 26, 2024 | https://doi.org/10.1371/journal.ppat.1012777

Human cytomegalovirus RNA2.7 inhibits ferroptosis by upregulating ferritin and GSH via promoting ZNF395 degradation

Mingyi Xu, Shan Ruan, Jingxuan Sun, Jianming Li, Dan Chen, Yanping Ma, Ying Qi, Zhongyang Liu, Qiang Ruan, Yujing Huang

PLOS Pathogens: published December 26, 2024 | https://doi.org/10.1371/journal.ppat.1012815

A Ralstonia solanacearum type III effector alters the actin and microtubule cytoskeleton to promote bacterial virulence in plants

Rachel Hiles, Abigail Rogers, Namrata Jaiswal, Weiwei Zhang, Jules Butchacas, Marcus V. Merfa, Taylor Klass, Pragya Barua, Venkatesh P. Thirumalaikumar, Jonathan M. Jacobs, Christopher J. Staiger, Matthew Helm, Anjali S. Iyer-Pascuzzi

PLOS Pathogens: published December 26, 2024 | https://doi.org/10.1371/journal.ppat.1012814

Alternative splicing expands the antiviral IFITM repertoire in Chinese rufous horseshoe bats

Nelly S.C. Mak, Jingyan Liu, Dan Zhang, Jordan Taylor, Xiaomeng Li, Kazi Rahman, Feiyu Chen, Siddhartha A.K. Datta, Kin Kui Lai, Zhengli Shi, Nigel Temperton, Aaron T. Irving, Alex A. Compton, Richard D. Sloan

PLOS Pathogens: published December 26, 2024 | https://doi.org/10.1371/journal.ppat.1012763

HIV-1 exploits LBPA-dependent intraepithelial trafficking for productive infection of human intestinal mucosa

Anusca G. Rader, Alexandra P. M. Cloherty, Kharishma S. Patel, Dima D. A. Almandawi, Dasja Pajkrt, Katja C. Wolthers, Adithya Sridhar, Sterre van Piggelen, Liselotte E. Baaij, Renée R. C. E. Schreurs, Carla M. S. Ribeiro

PLOS Pathogens: published December 27, 2024 | https://doi.org/10.1371/journal.ppat.1012714

Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection

Kiran Bala Sharma, Chandru Subramani, Khashpatika Ganesh, Anshula Sharma, Brohmomoy Basu, Shivani Balyan, Ghanshyam Sharma, Shouri KA, Arundhati Deb, Mitul Srivastava, Saurabh Chugh, Sapna Sehrawat, Kanchan Bharadwaj, Archana Rout, Pankaj Kumar Sahoo, Suman Saurav, Rajender K. Motiani, Ramandeep Singh, Deepti Jain, Shailendra Asthana, Renu Wadhwa, Sudhanshu Vrati

PLOS Pathogens: published December 30, 2024 | https://doi.org/10.1371/journal.ppat.1012816

The proteomic content of Varroa destructor gut varies according to the developmental stage of its host

Vincent Piou, Karim Arafah, Michel Bocquet, Philippe Bulet, Angélique Vétillard

PLOS Pathogens: published December 30, 2024 | https://doi.org/10.1371/journal.ppat.1012802

Cascading expression of ApiAP2 transcription factors controls daughter cell assembly in Toxoplasma gondii

Maanasa Bhaskaran, Venkat Mudiyam, Thomas Mouveaux, Emmanuel Roger, Mathieu Gissot

PLOS Pathogens: published December 30, 2024 | https://doi.org/10.1371/journal.ppat.1012810

MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi

Sajith Raghunandanan, Kai Zhang, Yan Zhang, Raj Priya, Ching Wooen Sze, Yongliang Lou, Michael J. Lynch, Brian R. Crane, Mark H. Kaplan, Chunhao Li, X. Frank Yang

PLOS Pathogens: published December 30, 2024 | https://doi.org/10.1371/journal.ppat.1012327

Differential contribution of PBP occupancy and efflux on the effectiveness of β-lactams at their target site in clinical isolates of Neisseria gonorrhoeae

Silvia López-Argüello, Eva Alcoceba, Paula Ordóñez, Biel Taltavull, Gabriel Cabot, Maria Antonia Gomis-Font, Antonio Oliver, Bartolome Moya

PLOS Pathogens: published December 31, 2024 | https://doi.org/10.1371/journal.ppat.1012783

Retraction: Fatal Prion Disease in a Mouse Model of Genetic E200K Creutzfeldt-Jakob Disease

The PLOS Pathogens Editors

PLOS Pathogens: published December 11, 2024 | https://doi.org/10.1371/journal.ppat.1012774

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The PLOS Pathogens Editors

PLOS Pathogens: published December 11, 2024 | https://doi.org/10.1371/journal.ppat.1012775

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The gut microbiota-independent virulence of noninvasive bacterial pathogen Citrobacter rodentium

Yue Liu, Dongqing Xu, Songwei Guo, Shuyu Wang, Hua Ding, Catherine Siu, Fengyi Wan

PLOS Pathogens: published December 4, 2024 | https://doi.org/10.1371/journal.ppat.1012758

SARS-CoV-2 infection of salivary glands compromises the production of a secreted antifungal peptide with potential implications for development of oral candidiasis

Areej A. Alfaifi, Tristan W. Wang, Paola Perez, Ahmed S. Sultan, Timothy F. Meiller, Peter Rock, David E. Kleiner, Daniel S. Chertow, Stephen M. Hewitt, Billel Gasmi, Sydney Stein, Sabrina Ramelli, Daniel Martin, Blake M. Warner, Mary Ann Jabra-Rizk

PLOS Pathogens: published December 12, 2024 | https://doi.org/10.1371/journal.ppat.1012375