From dysbiosis to mechanisms: Why cervicovaginal microbiome-HPV studies must catch up with biology

Mariano A. Molina

PLOS Pathogens: published December 30, 2025 | https://doi.org/10.1371/journal.ppat.1013830

The female reproductive tract-gut axis in gastrointestinal parasitic infection

Olivia Shorthouse, Alice H. Costain, Andrew S. MacDonald, Juan F. Quintana

PLOS Pathogens: published December 3, 2025 | https://doi.org/10.1371/journal.ppat.1013711

Transfer RNA regulation during herpesvirus infection: Wielding a sword or raising a shield?

Kyle Rapchak, Jessica M. Tucker

PLOS Pathogens: published December 5, 2025 | https://doi.org/10.1371/journal.ppat.1013750

Rooting for data: A FAIR research data management and data analysis environment for the PlantMicrobe research collaboration

Frederik Dröst, Ursula Eberhardt, Alexander Wellmann, Halima Saker, Simon Pirkl, Matthias Krinninger, Andreas Klingl, Eric Kemen, Nadia Kamal, Stephan Hachinger, Jens Krüger

PLOS Pathogens: published December 8, 2025 | https://doi.org/10.1371/journal.ppat.1013748

Friends and foes in the obligate plant pathobiome

Yiheng Hu, Marion Müller, Thomas Lahaye, Ralph Hückelhoven, Eric Kemen

PLOS Pathogens: published December 11, 2025 | https://doi.org/10.1371/journal.ppat.1013756

Lyme disease control 2.0: Advances and opportunities coming with Lyme disease vaccine VLA15

Ondrej Hajdusek, Kalvis Brangulis, Luise Robbertse, Rajesh Ghosh, Dino Di Carlo, Jan Perner

PLOS Pathogens: published December 15, 2025 | https://doi.org/10.1371/journal.ppat.1013747

Parasite nucleosomes: Chromatin dynamics rewired

Gauri Deák, Marcus D. Wilson

PLOS Pathogens: published December 15, 2025 | https://doi.org/10.1371/journal.ppat.1013781

Intracellular accommodation of bacteria, fungi, and oomycetes by plants analyzed using transmission electron microscopy

Isabella Gantner, Caroline Gutjahr, Martina K. Ried-Lasi, Andrea Cheradil, Julia Buchner, Martin Parniske, Andreas Klingl

PLOS Pathogens: published December 22, 2025 | https://doi.org/10.1371/journal.ppat.1013780

Essential redundancies fuel Mycobacterium tuberculosis adaptation to the host

Marco Silva, Alexandre J. Pinto, Tiago Beites

PLOS Pathogens: published December 5, 2025 | https://doi.org/10.1371/journal.ppat.1013749

Experimental models of liver-stage malaria: Progress, gaps, and challenges

Norapat Nitaramorn, Kasem Kulkeaw, Mallika Imwong

PLOS Pathogens: published December 18, 2025 | https://doi.org/10.1371/journal.ppat.1013796

Molecular response to the non-lytic peptide bac7 (1–35) triggers disruption of Klebsiella pneumoniae biofilm

Robert L. Beckman I.V, Berta Martinez, Flor Z. Santiago, Gabriela N. Echeverria, Bruno V. Pinheiro, Marcelo D.T. Torres, Logan Suits, Shantal Garcia, Paeton L. Wantuch, Cesar de la Fuente-Nunez, Prahathees Eswara, David A. Rosen, Renee M. Fleeman

PLOS Pathogens: published December 1, 2025 | https://doi.org/10.1371/journal.ppat.1013437

Lymphoid B cells upregulate HIV-1 ex vivo and are linked to its expression in vivo

Matthew T. Ollerton, Joy M. Folkvord, Veronica Bush, David A. Parry, Amie L. Meditz, Martin D. McCarter, Fred Yost, Cecilia M. Shikuma, Elizabeth Connick

PLOS Pathogens: published December 1, 2025 | https://doi.org/10.1371/journal.ppat.1013661

Quantifying plasmid movement in drug-resistant Shigella species using phylodynamic inference

Nicola F. Müller, Ryan R. Wick, Louise M. Judd, Deborah A. Williamson, Trevor Bedford, Benjamin P. Howden, Sebastián Duchêne, Danielle J. Ingle

PLOS Pathogens: published December 1, 2025 | https://doi.org/10.1371/journal.ppat.1013621

Gut bacteria induce heterologous immune priming in Rhodnius prolixus encompassing both humoral and cellular immune responses

Carissa A. Gilliland, Loretta Mugo-Kamiri, Sara Martin, Kevin J. Vogel

PLOS Pathogens: published December 1, 2025 | https://doi.org/10.1371/journal.ppat.1012947

Chemosensory protein 3 is a brain host factor for the induction of enhanced-locomotory activity in the BmNPV-silkworm infection model

Min Feng, Shigang Fei, Athanasios Papakyriakou, Eleanna Christodoulou, Wenxuan Lai, Wenjie Luo, Junming Xia, Yigui Huang, Spyros E. Zographos, Luc Swevers, Jingchen Sun

PLOS Pathogens: published December 1, 2025 | https://doi.org/10.1371/journal.ppat.1013701

Environmental regulation of toxin production in Bacillus anthracis

Ankur Bothra, Andrei Pomerantsev, Benjamin Schwarz, Anupam Mondal, Eric Bohrnsen, Nitika Sangwan, Kaitlin A. Stromberg, Mahtab Moayeri, Qian Ma, Rasem Fattah, Sundar Ganesan, Catharine M. Bosio, Stephen H. Leppla

PLOS Pathogens: published December 1, 2025 | https://doi.org/10.1371/journal.ppat.1013587

A single amino acid substitution in Fibronectin Binding protein A (FnBPA) governs Staphylococcus aureus virulence via host transglutaminase-mediated fibrin crosslinking

Chiara Motta, Mary Turley, Giulia Barbieri, Agata Famà, Francesco Coppolino, Elisa Bellan Menegussi, Joan A. Geoghegan, Concetta Beninati, Angelica Pellegrini, Giampiero Pietrocola

PLOS Pathogens: published December 1, 2025 | https://doi.org/10.1371/journal.ppat.1013743

Resolving inflammation: The impact of antiretroviral therapy on macrophage traffic in and out of the CNS

Zoey K. Wallis, Cecily C. Midkiff, Miaoyun Zhao, Patrick Autissier, Soon Ok Kim, Addison Q. Amadeck, Yiwei Wang, Maia Jakubowski, Tricia H. Burdo, Andrew D. Miller, Qingsheng Li, Xavier Alvarez, Robert V. Blair, Kenneth C. Williams

PLOS Pathogens: published December 1, 2025 | https://doi.org/10.1371/journal.ppat.1013180

Paramyxovirus matrix protein redirects METTL3 for dual regulation of viral replication and immune evasion

Takashi Okura, Yusuke Nakai, Taichi Kameya, Fuminori Mizukoshi, Hiyori Okura, Masatoshi Kakizaki, Fumihiro Kato, Yusuke Matsumoto, Yuichiro Nakatsu, Kaoru Takeuchi, Hirokazu Kimura, Makoto Takeda, Noriyuki Otsuki, Kazuya Shirato, Hideki Hasegawa, Akihide Ryo

PLOS Pathogens: published December 1, 2025 | https://doi.org/10.1371/journal.ppat.1013755

Bimodal expression of Type 3 Secretion System 2 enables cooperative virulence among intracellular Salmonella Typhimurium

Milada Pospíšilová, Alona Dreus, Paulina Matheova, Jana Schmidtova, Barbora Pravdova, Michaela Blazikova, Martin Capek, Ondrej Cerny

PLOS Pathogens: published December 1, 2025 | https://doi.org/10.1371/journal.ppat.1013728

Phase variation of Clostridioides difficile colony morphology occurs via modulation of cell division

Anchal Mehra, Elizabeth M. Garrett, Christopher J. Serody, Rita Tamayo

PLOS Pathogens: published December 1, 2025 | https://doi.org/10.1371/journal.ppat.1013471

Monocyte-eosinophil signaling axis promotes vaccine-mediated protection against SARS-CoV-2

Kathryn M. Moore, Stephanie L. Foster, Meenakshi Kar, Katharine A. Floyd, Elizabeth J. Elrod, M. Elliott Williams, Jacob Vander Velden, Madison Ellis, Ansa Malik, Bushra Wali, Stacey Lapp, Amanda Metz, Steven E. Bosinger, Vineet D. Menachery, Robert A. Seder, Rama Rao Amara, Jacob E. Kohlmeier, Arash Grakoui, Mehul S. Suthar

PLOS Pathogens: published December 2, 2025 | https://doi.org/10.1371/journal.ppat.1013752

Polo-like kinase 1 regulates growth in juvenile Fasciola hepatica

Paul McCusker, Nathan G. Clarke, Rebecca Armstrong, Duncan Wells, Emily Robb, Paul McVeigh, Andreas Krasky, John Harrington, Paul M. Selzer, Nikki J. Marks, Aaron G. Maule

PLOS Pathogens: published December 2, 2025 | https://doi.org/10.1371/journal.ppat.1013406

Phosphatase PP2A promotes RTA dephosphorylation to impair KSHV lytic replication

Lei Bai, Lianghui Dong, Jiazhen Dong, Xiaowei Liang, Jiangwei Peng, Yuncai Chen, Xiaoyi Sun, Yuting Chen, Xintong Li, Hua Cai, Jing Huang, Zixu Cao, Ke Lan

PLOS Pathogens: published December 3, 2025 | https://doi.org/10.1371/journal.ppat.1013731

KSHV TR deletion episomes uncover enhancer–promoter dynamics in gene regulation

Tomoki Inagaki, Ashish Kumar, Kang-Hsin Wang, Somayeh Komaki, Jonna M. Espera, Christopher S. A. Bautista, Ken-ichi Nakajima, Chie Izumiya, Yoshihiro Izumiya

PLOS Pathogens: published December 4, 2025 | https://doi.org/10.1371/journal.ppat.1013061

ARCN1 suppresses innate immune responses against respiratory syncytial virus by promoting STUB1-mediated IKKε degradation

Jiamin Cai, Yunfei Ye, Zhengrong Chen, Fei Xu, Xiaoping Li, Mengyun Wu, Ji Zhou, Yu Shao, Peijie Zhu, Jing Zhao, Jingjing Hu, Yufeng Wang, Cancheng Li, Xiaoyu Tian, Beibei Huang, Tian Xia, Wenjun Wang, Chuangli Hao, Yi Yang, Jinping Zhang

PLOS Pathogens: published December 4, 2025 | https://doi.org/10.1371/journal.ppat.1013751

Flaviviridae RdRp exploits NSUN2-driven m⁵C methylation to establish persistent infection

Jing Chen, Lin han Zhong, Jin xia Chen, Hui xin Song, Lin ke Zou, Xiao qing Bi, Bing qian Zhao, Mei zhen Li, Kun Li, Kang Wang, Jia jun Yang, Jin Cui, Li Wang, Bin Zhou

PLOS Pathogens: published December 4, 2025 | https://doi.org/10.1371/journal.ppat.1013765

The recombinant zoster vaccine induces trained immunity in monocytes through persistent downregulation of TGFβ

Michael J. Johnson, Megan Crotteau, Debashis Ghosh, Thao Vu, Luke Trinity, Radu Marches, Duygu Ucar, Myron J. Levin, Adriana Weinberg

PLOS Pathogens: published December 5, 2025 | https://doi.org/10.1371/journal.ppat.1013759

Meteorological and environmental drivers of West Nile virus prevalence in Culex pipiens mosquitoes in Emilia-Romagna, Italy in 2013 to 2022

Victoria M. Cox, Katie Tiley, Roberto Rosa, Andrea Pugliese, Paola Angelini, Marco Carrieri, Samir Bhatt, Marco Tamba, Giovanni Marini, Mattia Calzolari, Ilaria Dorigatti

PLOS Pathogens: published December 5, 2025 | https://doi.org/10.1371/journal.ppat.1013753

Heterologous expression of HCoV-HKU1 ORF 7b by mouse hepatitis virus protects against severe disease during murine infection

Chaminda D. Gunawardene, Isha Pandey, Shruti Chatterjee, Yoatzin Peñaflor-Téllez, Abby Odle, Abbey N. Warren, Adriana Messyasz, Ricardo Rajsbaum, Alan Sariol, Lok-Yin Roy Wong

PLOS Pathogens: published December 5, 2025 | https://doi.org/10.1371/journal.ppat.1013148

Engineering a multivalent antibody nanoparticle to overcome SARS-CoV-2 Omicron immune evasion

Hui Sun, Yanan Jiang, Miaolin Lan, Ming Zhou, Gangshun Yi, Juan Shen, Tingting Deng, Liqin Liu, Yang Huang, Yu Li, Jinfu Su, Yanling Lin, Zhenqin Chen, Lizhi Zhou, Tingting Li, Hai Yu, Tong Cheng, Yali Zhang, Lunzhi Yuan, Shaowei Li, Ying Gu, Peijun Zhang, Ningshao Xia, Qingbing Zheng

PLOS Pathogens: published December 8, 2025 | https://doi.org/10.1371/journal.ppat.1013744

SAMD9L inhibits flavivirus translation independently of its capacity to trigger innate immune response

Marion Cannac, Jim Zoladek, Inès Bribes, Mathis Fresneau--Resende, Alexandre Legrand, Rémi Demeure, Eva Zusinaite, Andres Merits, Lucie Etienne, Sébastien Nisole

PLOS Pathogens: published December 8, 2025 | https://doi.org/10.1371/journal.ppat.1013773

Rare metabolic gene essentiality is a determinant of microniche adaptation in Eschherichia coli

Omid Ardalani, Patrick V. Phaneuf, Jayanth Krishnan, Siddharth M. Chauhan, David Pride, Daniel C. Zielinski, Jonathan M. Monk, Lars K. Nielsen, Bernhard O. Palsson

PLOS Pathogens: published December 8, 2025 | https://doi.org/10.1371/journal.ppat.1013775

Natural competence in the bacterial pathogen Xylella fastidiosa varies across genotypes and is associated with adhesins

Ranlin Liu, María Pilar Velasco-Amo, Luis F. Arias-Giraldo, Monica A. Donegan, Neha Potnis, Nate B. Hardy, Rodrigo P. P. Almeida, Blanca B. Landa, Leonardo De La Fuente

PLOS Pathogens: published December 8, 2025 | https://doi.org/10.1371/journal.ppat.1013757

Quantitative ethology of schistosome miracidia characterizes a conserved snail peptide that inhibits host recognition

Rachel V. Horejsi, Chase N. Nelson, Avery De Ruyter, Helen M. Gensch, Saige Maasz-Seawright, Carly Weber, Sophie Willett, Sonja A. Olson, Nicolas J. Wheeler

PLOS Pathogens: published December 9, 2025 | https://doi.org/10.1371/journal.ppat.1013766

Antiviral and immune modulatory activities of STING agonists in a mouse model of persistent hepatitis B virus infection

Ya Wang, Shuo Wu, Xingqiong Li, Lijun Qiao, Huiqiang Wang, Ge Yang, Haiyan Yan, Kun Wang, Jian-Dong Jiang, Yuhuan Li

PLOS Pathogens: published December 9, 2025 | https://doi.org/10.1371/journal.ppat.1013709

TTSS-2 virulence drives inflammatory destruction of the gut epithelial barrier and modulates inflammatory response profiles in the Salmonella-infected mouse gut

Ursina Enz, Ersin Gül, Luca Maurer, Kamilė Čerepenkaitė, Jemina Huuskonen, Stefan A. Fattinger, Wolf-Dietrich Hardt

PLOS Pathogens: published December 10, 2025 | https://doi.org/10.1371/journal.ppat.1013733

High prevalence and emerging positive association of kelch13 R622I and HRP2-based RDT negativity in Plasmodium falciparum in northern Ethiopia

Ayalew Jejaw Zeleke, Abebe A. Fola, George A. Tollefson, Karamako Niaré, Alec Leonetti, Om Taropawala, Jacob Marglous, Rebecca Crudale, Bokretsion G. Brhane, Ashenafi Assefa, Patience Kiyuka, Jonathan B. Parr, Asrat Hailu, Mulugeta Aemero Tegegne, Jeffrey A. Bailey

PLOS Pathogens: published December 11, 2025 | https://doi.org/10.1371/journal.ppat.1013771

Calicivirus assembly and stability are mediated by the N-terminal domain of the capsid protein with the involvement of the viral genome

Guy Novoa, Carlos P. Mata, Johann Mertens, María Zamora‑Ceballos, Juan M. Martínez-Romero, Juan Fontana, José L. Carrascosa, Juan Bárcena, José R. Castón

PLOS Pathogens: published December 11, 2025 | https://doi.org/10.1371/journal.ppat.1013364

Wbm0152, an outer membrane lipoprotein of the Wolbachia endosymbiont of Brugia malayi, inhibits yeast ESCRT complex activity

Lindsay Berardi, Alora Colvin, Matthew West, Greg Odorizzi, Vincent J. Starai

PLOS Pathogens: published December 11, 2025 | https://doi.org/10.1371/journal.ppat.1013383

Capsular polysaccharide of Mycoplasma mycoides subsp. capri contributes to phenotypic diversity promoting distinctive immune responses

Thatcha Yimthin, Marilou Bourgeon, Jing Zhang, Lukas Eggerschwiler, Raphael Siegenthaler, Elise Schieck, Sergi Torres-Puig, Nicolas Ruggli, Thomas Démoulins, Joerg Jores

PLOS Pathogens: published December 12, 2025 | https://doi.org/10.1371/journal.ppat.1013386

Alternative polyadenylation upon CPSF6 knock-out enhances HIV-1 infection in primary T cells

Daphne Cornish, Kathryn A. Jackson-Jones, Ted Ling-Hu, Lacy M. Simons, William J. Cisneros, Edmund Osei Kuffour, Natalie Stegman, Francesca Agnes, Yujin Lee, Ved P. Sharma, Paul D. Bieniasz, Ramon Lorenzo-Redondo, Judd F. Hultquist

PLOS Pathogens: published December 12, 2025 | https://doi.org/10.1371/journal.ppat.1013745

Endophilin mediated endocytosis and epidermal growth factor receptor govern Japanese encephalitis virus entry and infection in neuronal cells

Puja Sharma, Mukesh Tanwar, Eira Choudhary, Nandhini M. Sundaram, Divya Ojha, Laxmi Mishra, Minu Nain, Ambadas Rode, Vidya Mangala Prasad, Sudhanshu Vrati, Manjula Kalia

PLOS Pathogens: published December 16, 2025 | https://doi.org/10.1371/journal.ppat.1013790

Activation of B1 B cells by F. tularensis atypical LPS depends on classical complement and C3a

Guilherme Melo, Carlos Henrique D. Barbosa, Elena Magrini, Cecilia Garlanda, Fabio Re

PLOS Pathogens: published December 17, 2025 | https://doi.org/10.1371/journal.ppat.1013799

Virulence evolution of a salmonid virus following a host jump

Malina M. Loeher, Gael Kurath, David A. Kennedy, Joanne E. Salzer, William N. Batts, Rachel B. Breyta, Andrew R. Wargo

PLOS Pathogens: published December 17, 2025 | https://doi.org/10.1371/journal.ppat.1013806

Cardiovirus-Mediated PKR inhibition results from nucleocytoplasmic trafficking disruption

Romane Milcamps, Belén Lizcano-Perret, Fanny Wavreil, Marielle Lebrun, Chiara Aloise, Didier Vertommen, Gaëtan Herinckx, Frank J.M. van Kuppeveld, Catherine Sadzot, Thomas Michiels

PLOS Pathogens: published December 17, 2025 | https://doi.org/10.1371/journal.ppat.1013420

Aptazyme-mediated gene regulation in Strongyloides stercoralis for functional studies of insulin receptor isoform specificity

Biying Zhang, Taoxun Zhou, Runxin Zhu, Peixi Qin, Juncheng Li, Chunqun Wang, Hui Liu, Min Hu

PLOS Pathogens: published December 17, 2025 | https://doi.org/10.1371/journal.ppat.1013774

Netrin-1 inhibits the attachment and internalization of Hepatitis B virus for hepatocyte infection

Ying Wang, Kazuhisa Murai, Atsuya Ishida, Narumi Kawasaki, Kazuyuki Kuroki, Ying-Yi Li, Yuga Sato, Yutaro Miura, Kureha Takara, Lianghao Kong, Tetsuro Shimakami, Kouki Nio, Yuichiro Higuchi, Hiroshi Suemizu, Satoru Ito, Hiroshi Yanagawa, Shuichi Kaneko, Taro Yamashita, Masao Honda

PLOS Pathogens: published December 17, 2025 | https://doi.org/10.1371/journal.ppat.1013776

Functional interplay between (p)ppGpp and RNAP in Acinetobacter baumannii

Anthony Perrier, Aurélie Budin-Verneuil, Régis Hallez

PLOS Pathogens: published December 18, 2025 | https://doi.org/10.1371/journal.ppat.1013795

A ‘Candidatus Liberibacter asiaticus’ effector SDE2470 facilitates citrus transcription factor CsVOZ2 degradation via BRUTUS E3 ligases

Shimin Fu, Xiaofeng Yang, Haoqing Zhao, Zuhui Yang, Jiajun Wang, Mingyue Qin, Changyong Zhou, Xuefeng Wang

PLOS Pathogens: published December 19, 2025 | https://doi.org/10.1371/journal.ppat.1013797

Inhibition of Wnt signaling in primary human hepatocytes promotes Plasmodium falciparum liver stage development

Abhishek Kanyal, Geert-Jan van Gemert, Haoyu Wu, Alex van der Starre, Johannes H.W. de Wilt, Teun Bousema, Robert W. Sauerwein, Richárd Bártfai, Annie S. P. Yang

PLOS Pathogens: published December 22, 2025 | https://doi.org/10.1371/journal.ppat.1013800

Comparative analysis of shared and unique mechanisms important for diverse strains of Pasteurella multocida to cause systemic infection in mice

Thomas R. Smallman, Xiaochu Wang, Xenia Kostoulias, Amy Wright, Faye C. Morris, Marina Harper, John D. Boyce

PLOS Pathogens: published December 22, 2025 | https://doi.org/10.1371/journal.ppat.1013398

Bat Dicer antiviral role and subcellular localization differ upon alphavirus infection in two distinct species

Léa Gaucherand, Hugo Marie, Julie Cremaschi, Sébastien Pfeffer

PLOS Pathogens: published December 22, 2025 | https://doi.org/10.1371/journal.ppat.1013815

Colanic acid-mediated phage resistance enhances virulence in high-risk global clone Escherichia coli ST410

Jieying Tu, Jun Yang, Kewei Song, Jinghan Wang, Nuoyan Zhang, Wanyun He, Jinghao Liu, Zhongpeng Cai, Yuman Bai, Luchao Lv, Bingqing Zhu, Pan Tao, Jie Feng, Jian-Hua Liu

PLOS Pathogens: published December 22, 2025 | https://doi.org/10.1371/journal.ppat.1013807

Mycobacterium tuberculosis manipulates LINC02528 in macrophages to modulate anti-tuberculosis metabolic immunity

Yuzhong Xu, Kehong Zhang, Sinan Li, Lin Qiao, Siwei Mo, Wenfei Wang, Jialou Zhu, Xiaoqian Liu, Ningjian Cai, Chenyan Shi, Yi Cai, Yunlong Hu, Xinchun Chen

PLOS Pathogens: published December 23, 2025 | https://doi.org/10.1371/journal.ppat.1013810

Metabolic reprogramming and gut microbiota ecology drive divergent Plasmodium vivax infection outcomes in Anopheles darlingi

Bianca Cechetto Carlos, Kamila Voges, Pedro Henrique de Andrade Affonso, Amie Jaye, Carlos Tong Rios, Bruno Tinoco-Nunes, Diego Peres Alonso, Julia A. Cai, Robert M. MacCallum, Marta Moreno, Dina Vlachou, Jayme A. Souza-Neto, George K. Christophides

PLOS Pathogens: published December 23, 2025 | https://doi.org/10.1371/journal.ppat.1013823

Cyclic-di-GMP controls Type III effector export and symptom development in Pseudomonas syringae infections via the export ATPase HrcN

Danny Ward, Richard H. Little, Catriona M. A. Thompson, Jacob G. Malone

PLOS Pathogens: published December 26, 2025 | https://doi.org/10.1371/journal.ppat.1013376

The early human interferon gamma response to Toxoplasma gondii is driven by Vγ9Vδ2 T-cell sensing of host phosphoantigens and subsequent NK-cell activation

Felipe Rodriguez, Jeroen P. J. Saeij

PLOS Pathogens: published December 26, 2025 | https://doi.org/10.1371/journal.ppat.1013829

A conserved enzymatic toolkit targeting host cell metabolism is associated with Cryptococcus neoformans intracellular survival in protozoal and mammalian phagocytic cells

Quigly Dragotakes, Ella Jacobs, Gracen Gerbig, Seth Greengo, Anne Jedlicka, Amanda Dziedzic, Arturo Casadevall

PLOS Pathogens: published December 26, 2025 | https://doi.org/10.1371/journal.ppat.1013787

Sclerotinia sclerotiorum growth and aggressiveness are regulated by a mycoviral REP protein

Peihan Shu, Yi-Wen Tseng, Alexander J. Lawrence, Chenchen Feng, Yasi Kiani, Olivia Knopke-Mooney, Rawnaq N. Chowdhury, Danny Lasky, Carol Groves, Damon L. Smith, Kinjal Majumder, Shin-Yi Lee Marzano, Aurélie M. Rakotondrafara

PLOS Pathogens: published December 26, 2025 | https://doi.org/10.1371/journal.ppat.1013813

Trans-complementation of chikungunya virus replicase mutants reveals alphavirus replication complexity and supports antiviral tool development

Sainan Wang, Krystyna Naumenko, Mandana Mirzajani Sarvandani, Laura Sandra Lello, Anna Makhotina, Hanna Carolina Claesson, Eva Žusinaite, Andres Merits

PLOS Pathogens: published December 26, 2025 | https://doi.org/10.1371/journal.ppat.1013838

A lignan compound regulates LPS modifications via PmrA/B signaling cascades to potentiate colistin efficacy in vivo

Qiuyue Diao, Zixing Zhong, Qin Zhong, Yidan Cao, Xiaona Fan, Yujiao Liang, Huihui Zhang, Zehua Cui, Xinlei Lian, Xiaoping Liao, Donghao Zhao, Jian Sun, Hao Ren

PLOS Pathogens: published December 29, 2025 | https://doi.org/10.1371/journal.ppat.1013843

Lipid scavenging by the Lyme disease spirochete Borrelia burgdorferi

Peter J. Gwynne, Jeffery S. Bourgeois, Aarya Pandit, John M. Asara, Linden T. Hu

PLOS Pathogens: published December 29, 2025 | https://doi.org/10.1371/journal.ppat.1013821

A wide diversity of viruses detected in African mammals involved in the wild meat supply chain

Mare Geraerts, Sophie Gombeer, Casimir Nebesse, Douglas Akaibe, Dudu Akaibe, Pascal Baelo, Anne-Lise Chaber, Philippe Gaubert, Guy-Crispin Gembu, Léa Joffrin, Anne Laudisoit, Nicolas Laurent, Herwig Leirs, Claude Mande, Joachim Mariën, Steve Ngoy, Jana Těšíková, Ann Vanderheyden, Rianne van Vredendaal, Erik Verheyen, Sophie Gryseels

PLOS Pathogens: published December 29, 2025 | https://doi.org/10.1371/journal.ppat.1013643

Large-particle aerosol exposure to the Bangladesh or Malaysia strain of Nipah virus results in markedly divergent disease presentation in African Green Monkeys

Yu Cong, Jeremy Bearss, Venkatesh Mani, Matthew Lackemeyer, Bapi Pahar, Louis M. Huzella, Erin Kollins, Steve Mazur, Saurabh Dixit, Sanae Lembirik, David Drawbaugh, Philip J. Sayre, Joseph Laux, Jeffrey Solomon, Dima A. Hammoud, Ji Hyun Lee, Claudia Calcagno, Russ Byrum, Marisa St. Claire, Jiro Wada, Vincent Munster, Michael R. Holbrook

PLOS Pathogens: published December 29, 2025 | https://doi.org/10.1371/journal.ppat.1013835

Valaciclovir therapy for secondary suppression of immune response to herpesviruses: An exploratory study

Kirsty McGee, Alex Dowell, Sarah Lauder, Jusnara Begum, Odette Chagoury, Wayne Croft, Lee Middleton, Yongzhong Sun, Jianmin Zuo, Richard McManus, Paul Moss

PLOS Pathogens: published December 29, 2025 | https://doi.org/10.1371/journal.ppat.1013803

Ureaplasma-driven inhibition of the epithelial Na⁺ transport in fetal alveolar cells: A novel mechanism of Ureaplasma-mediated preterm lung disease

Kirsten Glaser, Carl-Bernd Rieger, Elisabeth Paluszkiewicz, Ulrich H. Thome, Mandy Laube

PLOS Pathogens: published December 29, 2025 | https://doi.org/10.1371/journal.ppat.1013837

Ecological ubiquity and phylogeny drive nestedness in phages–bacteria networks and shape the bacterial defensome

Chloé Feltin, Sylvain Piry, Benoit Moury, Lola Chateau, Karine Berthier, Jonathan M. Jacobs, Jules Butchacas, Linda Fenske, Lillian Ebeling-Koning, Theo H. M. Smits, Cindy E. Morris, Clara Torres-Barceló

PLOS Pathogens: published December 30, 2025 | https://doi.org/10.1371/journal.ppat.1013428

Small granule protein CP2 of Cryptosporidium translocates to the parasite-host interface during invasion and localizes to parasitophorous vacuole membrane in association with other secretory proteins

Fuxian Yang, Yujin Huang, Ping Zhu, Shengchen Zhang, Jilei Huang, Haoyu Chen, Xiaoqing Gong, Yaqiong Guo, Na Li, Rui Xu, Yaoyu Feng, Lihua Xiao

PLOS Pathogens: published December 31, 2025 | https://doi.org/10.1371/journal.ppat.1013847

Host Protein Kinase C⍺: The novel Mitogen Activated Protein Kinase (MAPK) specific scaffold regulating nuclear export of influenza virus ribonucleoprotein complexes

Indrani Das Jana, Soumik Dey, Manoj Si, Arunava Roy, Arindam Mondal

PLOS Pathogens: published December 31, 2025 | https://doi.org/10.1371/journal.ppat.1013841

Flavivirus NS1-triggered endothelial dysfunction promotes virus dissemination

Henry Puerta-Guardo, Scott B. Biering, Bryan Castillo-Rojas, Michael J. DiBiasio-White, Nicholas T. N. Lo, Diego A. Espinosa, Colin M. Warnes, Chunling Wang, Thu M. Cao, Dustin R. Glasner, P. Robert Beatty, Richard J. Kuhn, Eva Harris

PLOS Pathogens: published December 31, 2025 | https://doi.org/10.1371/journal.ppat.1013811

Pp6-Pfkfb1 axis modulates intracellular bacterial proliferation by orchestrating host-pathogen metabolic crosstalk

Li Fan, Yang Sun, Fangzhou Lou, Zilong Fang, Wenxiang Ding, Xiangxiao Li, Yan Li, Qingqing Shen, Siyu Deng, Jihuan Liang, Fengjiao Zhang, Sibei Tang, Zhikai Wang, Xiaojie Cai, Jiajia Tong, Zhenyao Xu, Jing Zou, Qing Yang, Honglin Wang

PLOS Pathogens: published December 31, 2025 | https://doi.org/10.1371/journal.ppat.1013304

Correction: Biochemical and structural characterization of the human gut microbiome metallopeptidase IgAse provides insight into its unique specificity for the F_ab’ region of IgA1 and IgA2

Juan Sebastián Ramírez-Larrota, Pauline Juyoux, Pablo Guerra, Ulrich Eckhard, F. Xavier Gomis-Rüth

PLOS Pathogens: published December 4, 2025 | https://doi.org/10.1371/journal.ppat.1013742

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Correction: STAT3, MYC, and EBNA1 cooperate through a ZC3H18 transcriptional network to regulate survival and proliferation of EBV-positive lymphomas

Huanzhou Xu, Siva Koganti, Chenglong Li, Michael T. McIntosh, Sumita Bhaduri-McIntosh

PLOS Pathogens: published December 5, 2025 | https://doi.org/10.1371/journal.ppat.1013754

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Correction: FOXO regulates the expres sion of antimicrobial peptides and promotes phagocytosis of hemocytes in shrimp antibacterial immunity

Cang Li, Pan-Pan Hong, Ming-Chong Yang, Xiao-Fan Zhao, Jin-Xing Wang

PLOS Pathogens: published December 16, 2025 | https://doi.org/10.1371/journal.ppat.1013778

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Correction: Nep1-like proteins as a target for plant pathogen control

The PLOS Pathogens Editors

PLOS Pathogens: published December 17, 2025 | https://doi.org/10.1371/journal.ppat.1013758

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Correction: Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila

Alexandre Cammarata-Mouchtouris, Xuan-Hung Nguyen, Adrian Acker, François Bonnay, Akira Goto, Amir Orian, Marie-Odile Fauvarque, Michael Boutros, Jean-Marc Reichhart, Nicolas Matt

PLOS Pathogens: published December 18, 2025 | https://doi.org/10.1371/journal.ppat.1013785

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Correction: A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: Unveiling a novel virulence factor

Jeremy D. Volkening, Stephen J. Spatz, Maricarmen Garcia, Teresa A. Ross, Daniel A. Maekawa, Kenneth S. Rosenthal, Ana C. Zamora, April Skipper, Julia R. Blakey, Rashan Paudel

PLOS Pathogens: published December 19, 2025 | https://doi.org/10.1371/journal.ppat.1013791

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Correction: Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarials

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PLOS Pathogens: published December 29, 2025 | https://doi.org/10.1371/journal.ppat.1013814

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Correction: Proximity labelling reveals VPS13C as a regulator of Salmonella-containing vacuole fission

Anna K. Waldmann, Dustin A. Ammendolia, Andrew M. Sydor, Ren Li, Jonathan St-Germain, Brian Raught, John H. Brumell

PLOS Pathogens: published December 30, 2025 | https://doi.org/10.1371/journal.ppat.1013816

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Expression of Concern: The EBV latent antigen 3C inhibits apoptosis through targeted regulation of interferon regulatory factors 4 and 8

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PLOS Pathogens: published December 16, 2025 | https://doi.org/10.1371/journal.ppat.1013777

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