Dormant Pseudomonas aeruginosa bacteria (green) colonize tissues as single cells that can be observed here through the Drosophila cuticle, following their escape from the digestive tract in a newly developed latent infection model. They are tolerant to antibiotic treatments and retain their potential for virulence. Melanization, an arthropod-specific host defense plays a key role in the establishment of latency. This study underscores the plasticity of P. aeruginosa behavior in vivo depending on the infection route. Chen et al
Image Credit: Jing Chen
Editorial
PLOS Pathogens expanding horizons
PLOS Pathogens: published June 13, 2024 | https://doi.org/10.1371/journal.ppat.1012278
Pearls
The emergence of bacterial prions
PLOS Pathogens: published June 13, 2024 | https://doi.org/10.1371/journal.ppat.1012253
How can we escape the ESKAPEs: Antimicrobial resistance mechanisms and what lies ahead?
PLOS Pathogens: published June 13, 2024 | https://doi.org/10.1371/journal.ppat.1012270
Current and emerging issues in dermatophyte infections
PLOS Pathogens: published June 13, 2024 | https://doi.org/10.1371/journal.ppat.1012258
Reactive astrocytes in prion diseases: Friend or foe?
PLOS Pathogens: published June 20, 2024 | https://doi.org/10.1371/journal.ppat.1012286
A new landscape for malaria vaccine development
PLOS Pathogens: published June 27, 2024 | https://doi.org/10.1371/journal.ppat.1012309
Understanding viroids, endogenous circular RNAs, and viroid-like RNAs in the context of biogenesis
PLOS Pathogens: published June 27, 2024 | https://doi.org/10.1371/journal.ppat.1012299
Review
Functions and mechanisms of A-to-I RNA editing in filamentous ascomycetes
PLOS Pathogens: published June 6, 2024 | https://doi.org/10.1371/journal.ppat.1012238
Research Articles
Elucidating the spatio-temporal dynamics of the Plasmodium falciparum basal complex
PLOS Pathogens: published June 3, 2024 | https://doi.org/10.1371/journal.ppat.1012265
The BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection
PLOS Pathogens: published June 3, 2024 | https://doi.org/10.1371/journal.ppat.1012289
The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity
PLOS Pathogens: published June 3, 2024 | https://doi.org/10.1371/journal.ppat.1012271
A specific innate immune response silences the virulence of Pseudomonas aeruginosa in a latent infection model in the Drosophila melanogaster host
PLOS Pathogens: published June 4, 2024 | https://doi.org/10.1371/journal.ppat.1012252
Pulmonary inflammation and viral replication define distinct clinical outcomes in fatal cases of COVID-19
PLOS Pathogens: published June 5, 2024 | https://doi.org/10.1371/journal.ppat.1012222
Molecular and structural basis of oligopeptide recognition by the Ami transporter system in pneumococci
PLOS Pathogens: published June 5, 2024 | https://doi.org/10.1371/journal.ppat.1011883
Deficiency in non-classical major histocompatibility class II-like molecule, H2-O confers protection against Staphylococcus aureus in mice
PLOS Pathogens: published June 6, 2024 | https://doi.org/10.1371/journal.ppat.1012306
Heightened Epstein-Barr virus immunity and potential cross-reactivities in multiple sclerosis
PLOS Pathogens: published June 6, 2024 | https://doi.org/10.1371/journal.ppat.1012177
Temporal regulation of MDA5 inactivation by Caspase-3 dependent cleavage of 14-3-3η
PLOS Pathogens: published June 6, 2024 | https://doi.org/10.1371/journal.ppat.1012287
Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics
PLOS Pathogens: published June 6, 2024 | https://doi.org/10.1371/journal.ppat.1012235
The histone methyltransferase SETD2 regulates HIV expression and latency
PLOS Pathogens: published June 7, 2024 | https://doi.org/10.1371/journal.ppat.1012281
The anti-apoptotic function of HSV-1 LAT in neuronal cell cultures but not its function during reactivation correlates with expression of two small non-coding RNAs, sncRNA1&2
PLOS Pathogens: published June 10, 2024 | https://doi.org/10.1371/journal.ppat.1012307
IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission
PLOS Pathogens: published June 10, 2024 | https://doi.org/10.1371/journal.ppat.1012308
Herpes simplex virus spreads rapidly in human foreskin, partly driven by chemokine-induced redistribution of Nectin-1 on keratinocytes
PLOS Pathogens: published June 10, 2024 | https://doi.org/10.1371/journal.ppat.1012267
The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine
PLOS Pathogens: published June 10, 2024 | https://doi.org/10.1371/journal.ppat.1012246
Pathogenic differences of cynomolgus macaques after Taï Forest virus infection depend on the viral stock propagation
PLOS Pathogens: published June 11, 2024 | https://doi.org/10.1371/journal.ppat.1012290
Natural variation in infection specificity of Caenorhabditis briggsae isolates by two RNA viruses
PLOS Pathogens: published June 11, 2024 | https://doi.org/10.1371/journal.ppat.1012259
Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice
PLOS Pathogens: published June 11, 2024 | https://doi.org/10.1371/journal.ppat.1011915
Arboviruses antagonize insect Toll antiviral immune signaling to facilitate the coexistence of viruses with their vectors
PLOS Pathogens: published June 12, 2024 | https://doi.org/10.1371/journal.ppat.1012318
Temporal and spatial dynamics of Plasmodium falciparum clonal lineages in Guyana
PLOS Pathogens: published June 13, 2024 | https://doi.org/10.1371/journal.ppat.1012013
Antiviral activity of intracellular nanobodies targeting the influenza virus RNA-polymerase core
PLOS Pathogens: published June 14, 2024 | https://doi.org/10.1371/journal.ppat.1011642
Zinc-finger (ZiF) fold secreted effectors form a functionally diverse family across lineages of the blast fungus Magnaporthe oryzae
PLOS Pathogens: published June 17, 2024 | https://doi.org/10.1371/journal.ppat.1012277
Wolbachia mediates crosstalk between miRNA and Toll pathways to enhance resistance to dengue virus in Aedes aegypti
PLOS Pathogens: published June 17, 2024 | https://doi.org/10.1371/journal.ppat.1012296
Zn2+-dependent association of cysteine-rich protein with virion orchestrates morphogenesis of rod-shaped viruses
PLOS Pathogens: published June 17, 2024 | https://doi.org/10.1371/journal.ppat.1012311
Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis
PLOS Pathogens: published June 17, 2024 | https://doi.org/10.1371/journal.ppat.1012319
Dissecting positive selection events and immunological drives during the evolution of adeno-associated virus lineages
PLOS Pathogens: published June 17, 2024 | https://doi.org/10.1371/journal.ppat.1012260
Chlamydia trachomatis induces disassembly of the primary cilium to promote the intracellular infection
PLOS Pathogens: published June 17, 2024 | https://doi.org/10.1371/journal.ppat.1012303
MicroRNA-focused CRISPR/Cas9 screen identifies miR-142 as a key regulator of Epstein-Barr virus reactivation
PLOS Pathogens: published June 17, 2024 | https://doi.org/10.1371/journal.ppat.1011970
CD56-mediated activation of human natural killer cells is triggered by Aspergillus fumigatus galactosaminogalactan
PLOS Pathogens: published June 18, 2024 | https://doi.org/10.1371/journal.ppat.1012315
Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions
PLOS Pathogens: published June 20, 2024 | https://doi.org/10.1371/journal.ppat.1011569
N-acetylglucosamine supplementation fails to bypass the critical acetylation of glucosamine-6-phosphate required for Toxoplasma gondii replication and invasion
PLOS Pathogens: published June 20, 2024 | https://doi.org/10.1371/journal.ppat.1011979
The role of socio-economic disparities in the relative success and persistence of SARS-CoV-2 variants in New York City in early 2021
PLOS Pathogens: published June 20, 2024 | https://doi.org/10.1371/journal.ppat.1012288
Alpha-defensin binding expands human adenovirus tropism
PLOS Pathogens: published June 20, 2024 | https://doi.org/10.1371/journal.ppat.1012317
Human cytomegalovirus deploys molecular mimicry to recruit VPS4A to sites of virus assembly
PLOS Pathogens: published June 20, 2024 | https://doi.org/10.1371/journal.ppat.1012300
Human coronavirus NL63 nsp1 induces degradation of RNA polymerase II to inhibit host protein synthesis
PLOS Pathogens: published June 20, 2024 | https://doi.org/10.1371/journal.ppat.1012329
PoRVA G9P[23] and G5P[7] infections differentially promote PEDV replication by reprogramming glutamine metabolism
PLOS Pathogens: published June 21, 2024 | https://doi.org/10.1371/journal.ppat.1012305
Histone demethylase JMJD2D protects against enteric bacterial infection via up-regulating colonic IL-17F to induce β-defensin expression
PLOS Pathogens: published June 21, 2024 | https://doi.org/10.1371/journal.ppat.1012316
Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection
PLOS Pathogens: published June 24, 2024 | https://doi.org/10.1371/journal.ppat.1011777
Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Ebola, Sudan, Marburg and Lassa viruse
PLOS Pathogens: published June 26, 2024 | https://doi.org/10.1371/journal.ppat.1012262
Characterising plasmacytoid and myeloid AXL+ SIGLEC-6+ dendritic cell functions and their interactions with HIV
PLOS Pathogens: published June 26, 2024 | https://doi.org/10.1371/journal.ppat.1012351
Generation of a bloodstream form Trypanosoma brucei double glycosyltransferase null mutant competent in receptor-mediated endocytosis of transferrin
PLOS Pathogens: published June 27, 2024 | https://doi.org/10.1371/journal.ppat.1012333
The lipopeptide Pam3CSK4 inhibits Rift Valley fever virus infection and protects from encephalitis
PLOS Pathogens: published June 27, 2024 | https://doi.org/10.1371/journal.ppat.1012343
Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites
PLOS Pathogens: published June 27, 2024 | https://doi.org/10.1371/journal.ppat.1012360
The NS2B-PP1α-eIF2α axis: Inhibiting stress granule formation and Boosting Zika virus replication
PLOS Pathogens: published June 27, 2024 | https://doi.org/10.1371/journal.ppat.1012355
Short Reports
Pseudo-pac site sequences used by phage P22 in generalized transduction of Salmonella
PLOS Pathogens: published June 24, 2024 | https://doi.org/10.1371/journal.ppat.1012301