Pervasive HIV recombination limits the utility of circulating recombinant form nomenclature

Heather E. Grant, Abayomi S. Olabode, Dorothea Seiler Vellame, Art F. Y. Poon, Andrew J. Leigh Brown, David L. Robertson

PLOS Pathogens: published July 13, 2026 | https://doi.org/10.1371/journal.ppat.1014286

How Saprolegniales became successful parasites

Paula Ortega-López, Javier Diéguez-Uribeondo

PLOS Pathogens: published July 2, 2026 | https://doi.org/10.1371/journal.ppat.1014359

The hidden costs of using media to mimic the hosts of Fusarium graminearum: An epigenetic perspectives

Jade F. Smith, Hans-Wilhelm Nuetzmann, Martin Darino, Kim E. Hammond-Kosack

PLOS Pathogens: published July 7, 2026 | https://doi.org/10.1371/journal.ppat.1014345

Complement evasion by apicomplexans: Convergent strategies across diverse parasites

Sofía Espinosa-Hernández, Carlos J. Ramírez-Flores

PLOS Pathogens: published July 17, 2026 | https://doi.org/10.1371/journal.ppat.1014435

Mind the gap between RNA and protein levels: A general phenomenon with implications for virology

Luca D. Bertzbach, Timon Kapischke, Lars Kaderali, Stephanie Pfaender, Wing-Hang Ip

PLOS Pathogens: published July 30, 2026 | https://doi.org/10.1371/journal.ppat.1014470

Dangerous liaisons: Candidalysin and myeloid cells in candidiasis

Zi-Qi Gu, You-Yan Chen, Yu-Huan Tsai

PLOS Pathogens: published July 31, 2026 | https://doi.org/10.1371/journal.ppat.1014467

HIV capsid inhibitors: Mechanisms, resistance, and therapeutic advances

Mohamed Mahdi, Botond Lakatos, János András Mótyán, Gyula Hoffka, József Tőzsér

PLOS Pathogens: published July 10, 2026 | https://doi.org/10.1371/journal.ppat.1014361

The brain as an HIV reservoir: Recent findings using autopsy tissues from people with HIV

Rajnish S. Dave, Ayo A. Oludipe, Elizabeth C. Pasipanodya, Seth Sherman, Steffanie H. Wilson, Dana H. Gabuzda, Melissa J. Churchill, Thomas A. Angelovich, Robert J. Gorelick, Sara Gianella, Antoine Chaillon, Jerel Adam Fields, Susan Morgello, Benjamin B. Gelman, David J. Moore, Elyse J. Singer, Beau M. Ances, Howard S. Fox

PLOS Pathogens: published July 29, 2026 | https://doi.org/10.1371/journal.ppat.1014446

RNF31 restricts EV-A71 replication through innate immune activation and VP4 degradation, and is antagonized by viral 3C proteases

Qingxiang Zhang, Yuan Gao, Wenying Gao, Xue Zhang, Shengyuan Xu, Wenyan Zhang

PLOS Pathogens: published July 2, 2026 | https://doi.org/10.1371/journal.ppat.1014415

Anti-malarial contact dependent blocking of transmission of Plasmodium vivax by Anopheles darlingi mosquito vector

Jéssica E. A. Kassupá, Alice O. Andrade, Alessandra S. Bastos, Gabriel L. L. Moura, Marina L. Rocha, Leandro N. Martinez, Elisandra K. S. Afonso, Wallyson J. Costa, Daniel Y. Bargieri, Carolina B. G. Teles, Jansen F. Medeiros, Nirbhay Kumar, Ana Carolina R. Guimarães, Douglas G. Paton, Flaminia Catteruccia, Maisa S. Araujo

PLOS Pathogens: published July 2, 2026 | https://doi.org/10.1371/journal.ppat.1013531

Staphylococcus aureus rewires arginine metabolism to drive mammary aging via macrophage–epithelial crosstalk

Yuhang Jin, Kai Yang, Ruoxi Sun, Yu Cao, Dewei He, Junlong Bi, Wenjin Guo, Shoupeng Fu

PLOS Pathogens: published July 6, 2026 | https://doi.org/10.1371/journal.ppat.1014403

The Bunyamwera orthobunyavirus Gc glycoprotein head and stalk drives an infectious virion assembly pathway specific for the insect host

Amelia B. Shaw, Hiu Nam Tse, Molly V. Durawa, Owen Byford, Hayley M. Pearson, Kenneth A. Stapleford, Juan Fontana, John N. Barr

PLOS Pathogens: published July 7, 2026 | https://doi.org/10.1371/journal.ppat.1014374

Shiga toxin delivery in extracellular vesicles induces high mortality and severe kidney injury in a Gb3-dependent manner

Markus Wendler, Alexandra Gerogianni, Johan Rebetz, Lazaro Hiram Betancourt Nunez, Patrik Önnerfjord, Ida Arvidsson, Diana Karpman

PLOS Pathogens: published July 7, 2026 | https://doi.org/10.1371/journal.ppat.1014421

Novel duck reovirus σC hijacks the mitochondrial COQ6–CoQ10 axis to drive NLRP3-dependent pyroptosis

Hui Yan, Lei Bei, Mingrui Zhao, Jiajun Wang, Pengxiang Jin, Chunmei Xu, Lin Ju, Yu Meng, Shijin Jiang, Ruihua Zhang

PLOS Pathogens: published July 7, 2026 | https://doi.org/10.1371/journal.ppat.1014392

A rotavirus vaccine candidate attenuated by codon deoptimization protects neonatal mice against wild-type virus infection

Zelin Chen, Tomohiro Kotaki, Daisuke Motooka, Shintaro Sato, Yusuke Sakai, Katsuhisa Hirai, Shohei Minami, Takahiro Kawagishi, Yuta Kanai, Takeshi Kobayashi

PLOS Pathogens: published July 7, 2026 | https://doi.org/10.1371/journal.ppat.1014292

Japanese encephalitis virus hijacks the host purine biosynthetic network to promote viral replication in neurons

Jun Gu, Chencheng Fan, Shengxian Xiang, Ling’en Yang, Jia Liu, Youhui Si, Bibo Zhu, Yingjie Sun, Chan Ding, Shengbo Cao, Jing Ye

PLOS Pathogens: published July 7, 2026 | https://doi.org/10.1371/journal.ppat.1014335

G protein-coupled receptor SmGPCR9 interacts with neuropeptides and controls spermatogenesis in Schistosoma mansoni

Saranya Geetha, Simone Haeberlein, Steffen Hahnel, Xuesong Li, Daniel J. Sprague, Yuri K. Peterson, Shafqat Shabir, Franco H. Falcone, Moritz Buenemann, Christoph G. Grevelding

PLOS Pathogens: published July 7, 2026 | https://doi.org/10.1371/journal.ppat.1014096

Naturally occurring mutations in replication proteins of a small RNA virus that alter the number, sizes, and relative abundances of subgenomic RNAs

Camila Perdoncini Carvalho, Deya Wang, Junping Han, Khwannarin Khemsom, Hanqiao Chen, Yizhi Tao, Feng Qu

PLOS Pathogens: published July 7, 2026 | https://doi.org/10.1371/journal.ppat.1013842

Subversion of the salicylic acid signaling pathway by the bipartite begomoviral protein BV1 promotes virus infection and vector preference to virus-infected plants

Guan-Ping Chen, Di Li, Xing Zhang, Ming-Yang Yu, Jing-Ru Zhang, Wilmer J. Cuellar, Xiao-Wei Wang, Shu-Sheng Liu, Yin-Quan Liu, Li-Long Pan

PLOS Pathogens: published July 7, 2026 | https://doi.org/10.1371/journal.ppat.1014354

Sialic acids are a barrier to the entry of non-influenza orthomyxoviruses

Gabriel Dupré, Jorge Moreno-García, Elias Bendl, Georg Kochs, Jérémy Dufloo, Rafael Sanjuán

PLOS Pathogens: published July 8, 2026 | https://doi.org/10.1371/journal.ppat.1013902

A structure-based epitope tagging approach identifies vulnerable sites on the malarial P36-P52 protein complex for antibody-mediated neutralization of Plasmodium sporozoites

Samhita Das, Lien Boeykens, Manon Loubens, Carine Marinach, Sylvie Briquet, Line De Vocht, Isabel Pintelon, Jean-Pierre Timmermans, Yann G.-J. Sterckx, Olivier Silvie

PLOS Pathogens: published July 8, 2026 | https://doi.org/10.1371/journal.ppat.1014418

Independent proviral and antiviral host factors recognize the same capsid protein in divergent human herpesviruses

Yiqi Zhao, Sarah Probert, Jan Birkel, Xin Liu, Yaling Shi, Olivia Shulan Yang, Kangyan Zhao, Yongxu Lu, Geoffrey L. Smith

PLOS Pathogens: published July 8, 2026 | https://doi.org/10.1371/journal.ppat.1014376

Host-specific ubiquitination of prM orchestrates ESCRT recruitment to mediate efficient Japanese Encephalitis Virus assembly in vertebrates

Chenxi Li, Wenzhuang Guo, Wen Zhao, Linjie Zhang, Chenyang Tang, Jingjing Li, Jing Shi, Mingan Sun, Yanhua Li

PLOS Pathogens: published July 8, 2026 | https://doi.org/10.1371/journal.ppat.1014426

Glycoprotein G enables HSV-2 neuroinvasion and provides protection as a glycosylated vaccine antigen

Ebba Könighofer, Carolina Gustafsson, Lindvi Gudmundsdotter, Ekaterina Mirgorodskaya, Jonas Nilsson, Maria Ekblad, Beata Adamiak, Eva Jennische, Stefan Lange, Edward Trybala, Staffan Görander, Tomas Bergström, Jan-Åke Liljeqvist, Rickard Nordén

PLOS Pathogens: published July 9, 2026 | https://doi.org/10.1371/journal.ppat.1014339

Defense against parasites covaries with reproductive timing, not with resistance

Amanda Kyle Gibson, Linyao Peng, Tessa E. Batterton, Neha Channamraju, Victoria K. Feist, Sarah D. Hesse, Anne N. Janisch, Hongyi Shui

PLOS Pathogens: published July 9, 2026 | https://doi.org/10.1371/journal.ppat.1014388

Provision of preferred nutrients to macrophages promotes Salmonella intracellular replication without relying on Type III secretion systems

Francisco-Javier Garcia-Rodriguez, Paula Martinez-Oca, Camila Valenzuela, Joaquin Bernal-Bayard, Pedro Escoll

PLOS Pathogens: published July 9, 2026 | https://doi.org/10.1371/journal.ppat.1014348

Reduced inflammatory and Th1 transcriptional profiles in geriatric versus adult cotton rats infected with respiratory syncytial virus

Jonathan Miller, Cameron Leedale, Ayse Selen Yilmaz, Emily Pawlack, Jèssica Gómez Garrido, Tyler Alioto, Lianbo Yu, David E. Symer, Stefan Niewiesk

PLOS Pathogens: published July 9, 2026 | https://doi.org/10.1371/journal.ppat.1014323

Characterisation of the thermal and non-thermal stress conditions that activate the Plasmodium falciparum AP2-HS-dependent heat-shock response

Neus Ràfols, Prince B. Nyarko, Marc Chillarón-Adán, Elisabet Tintó-Font, Alfred Cortés

PLOS Pathogens: published July 9, 2026 | https://doi.org/10.1371/journal.ppat.1014346

N-linked glycosylation of NS1 protein modulates progeny virion assembly in orthoflaviviruses

Senzhao Zhang, Xuedan Tang, Zhen Wu, Hantai Tan, Yan Zhang, Wangyang Tan, Yu He, Tao Wang, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Bin Tian, Anchun Cheng, Shun Chen

PLOS Pathogens: published July 9, 2026 | https://doi.org/10.1371/journal.ppat.1014408

STING agonist protects against exacerbation of schistosome egg-induced immunopathology

Pengyu Liu, Megan S. Linnane, Kaile Jump, Shuchang Tian, Santoshi Chaudhary, Rajeswaran Mani, Jordan E. Bisanz, Parisa Kalantari

PLOS Pathogens: published July 10, 2026 | https://doi.org/10.1371/journal.ppat.1014394

TANK potentiates antiviral innate immunity by recruiting deubiquitinase USP46 to activate IKKε

Zhenghao Li, Can Yang, Juanjuan Shu, Jiaxin Wang, Xinyu Wang, Shasha Tan, Ji Liu, Jun Xiao, Jiaji Pan, Xing Feng, Hui Wu, Hao Feng

PLOS Pathogens: published July 10, 2026 | https://doi.org/10.1371/journal.ppat.1014412

Characterization of an immunocompetent, young adult mouse model for studying chikungunya virus neuroinvasion and central nervous system infection

Alyssa M. Lantz, Freedom M. Green, Amanda J. Cowan, Kestrel A. Miller, Reina A. Saldivar, Elizabeth J. Anderson, Ramya S. Barre, Vinay Shivanna, William B. Klimstra, Luis Martinez-Sobrido, Victoria K. Baxter

PLOS Pathogens: published July 10, 2026 | https://doi.org/10.1371/journal.ppat.1014395

Structural requirements of blood factors binding to soluble hexon trimers with implications for adenovirus cell targeting and immune evasion

Olivia X. Ma, Shao-Chia Lu, Haley E. Mudrick, Mary E. Barry, Jarrod B. French, Michael A. Barry, Vijay S. Reddy

PLOS Pathogens: published July 13, 2026 | https://doi.org/10.1371/journal.ppat.1014389

Quantification and localization of integrated HIV-1 in memory and naïve CD4+ T cells from adolescents and young adults with perinatally-acquired HIV-1

Adit Dhummakupt, Alexander G. McFarland, Joseph Szewczyk, John Everett, Carole Lee, Aoife M. Roche, Soumia Bekka, Thuy Anderson, Allison L. Agwu, Frederic D. Bushman, Deborah Persaud

PLOS Pathogens: published July 13, 2026 | https://doi.org/10.1371/journal.ppat.1014369

Two folds, many faces: The Magnaporthe oryzae MAX effector AVR-Pia targets novel rice HMA domain-containing proteins

Josephine H. R. Maidment, Svenja C. Saile, Aurélien Bocquet, Céline Thivolle, Léo Bourcet, Lisa-Fatimatou Planel, Muriel Gelin, Thomas Kroj, André Padilla, Karine de Guillen, Stella Cesari

PLOS Pathogens: published July 13, 2026 | https://doi.org/10.1371/journal.ppat.1014382

Biofilm-derived curli and Z-DNA shape anti-DNA antibody responses during Salmonella infections

Molly Elkins, Kaitlyn Grando, Courtney Covolo, Diane Spencer, Jacob F. Maziarz, Erin M. Vasicek, Carly DeAntoneo, Francisco J. Albicoro, Shingo Bessho, Zachary W. Reichenbach, Sophia Olubajo, Bettina Buttaro, Siddharth Balachandran, John S. Gunn, David Pisetsky, Çagla Tükel

PLOS Pathogens: published July 14, 2026 | https://doi.org/10.1371/journal.ppat.1014047

Acinetobacter baumannii lipooligosaccharide core region promotes CD14-dependent TLR4 endocytosis and enhances pathogenicity through interferon-β production

Yi-Tzu Lee, Te-Li Chen, Shu-Chen Kuo, Yu-Han Liu, Meng-Chang Lee, Ming-Fen Chuang, Mei-Chei Tan, I-Ming Lee, Ya-Sung Yang, Yung-Chih Wang

PLOS Pathogens: published July 14, 2026 | https://doi.org/10.1371/journal.ppat.1014364

Unveiling a missing component of the atypical type IV secretion system required for natural transformation of Helicobacter pylori

J. Francisco Villa, Sumedha Kondekar, Yoann Fauconnet, Mérick Machouri, Céline Lacrouts, Xavier Veaute, Raphaël Guérois, Eduardo P. C. Rocha, Jessica Andreani, J. Pablo Radicella

PLOS Pathogens: published July 14, 2026 | https://doi.org/10.1371/journal.ppat.1014140

Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region

Suzanne D. E. Ruijten, Jéssica C. dos Santos, Victoria Rios-Vazquez, Adriana Navas, Hanneke Maas, Albert L. Groenendijk, Marc J. T. Blaauw, Louise E. van Eekeren, Wilhelm A. J. W. Vos, Rainer Knoll, Manoj Kumar Gupta, Rob ter Horst, Javier Botey-Bataller, Nienke van Unen, Yang Li, Anna C. Aschenbrenner, Joachim L. Schultze, Cheng-Jian Xu, Mihai G. Netea, Andre J. A. M. van der Ven, Vasiliki Matzaraki

PLOS Pathogens: published July 14, 2026 | https://doi.org/10.1371/journal.ppat.1014355

Macrophage-mediated antibiotic evasion and competitive dominance of mcr-3-carrying Escherichia coli

Shuyu Tan, Wenjuan Yin, Jian Sun, Wenguang Xiong, Yina An, Lu Qiao, Pu Zhang, Siqi Sun, Qianru Li, Leiming Fu, Yifan Liu, Yaqian Xue, Shuyi Huang, Yixi Liu, Yang Wang, Yanjun Dong

PLOS Pathogens: published July 14, 2026 | https://doi.org/10.1371/journal.ppat.1014427

A mouse model of Zika virus sexual transmission reveals a limited transmission window shorter than viral RNA persistence in semen

Jia-Tong Chang, Zhan-Zhan Bian, Lin-Shen-Yang Liu, Dong-Ying Fan, Xiao-Feng Qin, Nan Zhang, Hui Chen, Wei Yang, Pei-Gang Wang, Jing An

PLOS Pathogens: published July 14, 2026 | https://doi.org/10.1371/journal.ppat.1014420

Rasputin/G3BP mediates subversion of antiviral immunity by o’nyong-nyong virus in Anopheles coluzzii

Solène Cottis, Adrien A. Blisnick, Emma Brito-Fravallo, Mariette Matondo, Kenneth D. Vernick, Anna-Bella Failloux, Christian Mitri

PLOS Pathogens: published July 14, 2026 | https://doi.org/10.1371/journal.ppat.1014423

Structural basis of a conserved, broad antigenic region surrounding the five-fold axis of foot-and-mouth disease virus revealed by swine neutralizing antibodies

Qiongqiong Zhao, Shanquan Wu, Fengjuan Li, Lv Lv, Shulun Huang, Jiaxin Yang, Zhanhui Zhu, Ying Sun, Pinghua Li, Yimei Cao, Huifang Bao, Pu Sun, Xingwen Bai, Zhixun Zhao, Jing Zhang, Jinyan Wu, Hong Yuan, Jijun He, Xiangmin Li, Zengjun Lu, Dongsheng Lei, Kun Li

PLOS Pathogens: published July 14, 2026 | https://doi.org/10.1371/journal.ppat.1014357

Genome-wide CRISPR screen reveals PEX11B as a host restriction factor against ORFV through membrane fluidity regulation

Xiaoran Gao, Jinyang Hao, Sha Lu, Shida Wang, Yu Sun, Xin Ke, Xia Gao, Yuan Su, Yuze Sun, Yu Tian, Wenyu Yan, Jinliang Wang, Zhong Zheng, Rong Hai, Qianyi Zhang, Jingfei Wang, Wei Hu, Guojun Wang

PLOS Pathogens: published July 15, 2026 | https://doi.org/10.1371/journal.ppat.1013767

Longitudinal analysis of high-risk HPV infections reveals within-host viral genome changes over time

Sambit K. Mishra, Meredith Yeager, Chase W. Nelson, Bin Zhu, Laurie Burdett, Robert D. Burk, Michael Dean, Rolando Herrero, Mark Schiffman, Ana Cecilia Rodriguez, Lisa Mirabello

PLOS Pathogens: published July 15, 2026 | https://doi.org/10.1371/journal.ppat.1014362

Dynamic tethering of M protein drives pathological inflammation during group A Streptococcus infections

Ananya Dash, Stephanie Guerra, Doris L. LaRock, Richa S. Varughese, Paola Vidal, Alison Swaims-Kohlmeier, Christopher N. LaRock

PLOS Pathogens: published July 15, 2026 | https://doi.org/10.1371/journal.ppat.1014434

Respiratory viruses activate autophagy via the IFN-STAT1/STAT5B-SOCS1 axis

Victoria Hunszinger, Susanne Klute, Zoé Engels, Helene Hoenigsperger, Lennart Koepke, Helen Dürr, Jana-Romana Fischer, Birgit Ott, Alexander Graf, Stefan Krebs, Helmut Blum, Frank Kirchhoff, Maximilian Hirschenberger, Konstantin M. J. Sparrer

PLOS Pathogens: published July 15, 2026 | https://doi.org/10.1371/journal.ppat.1014414

Salmonella effector kinase SteC is activated by phosphorylation at Serine 379

Timesh D. Pillay, Briac Lemetais, Jessica Huber, Ines Diaz del Olmo, Daniel Zhang, Yan Li, Laura Masino, Sarah Maslen, Mei Liu, Diego Esposito, Jay C. D. Hinton, Xiujun Yu, Teresa L. M. Thurston, Katrin Rittinger

PLOS Pathogens: published July 16, 2026 | https://doi.org/10.1371/journal.ppat.1014424

The antiviral GTPase MxB is packaged into virions and binds via its N-terminal domain to alphaherpesvirus capsids

Sebastian Weigang, Manutea C. Serrero, Boris Bogdanow, Franziska Hüsers, Julia Lückel, Rudolf Bauerfeind, Fan Liu, Georg Kochs, Beate Sodeik

PLOS Pathogens: published July 16, 2026 | https://doi.org/10.1371/journal.ppat.1014370

Induction of neutralising antibodies against conserved rhinovirus capsid protein VP4 is dependent on presentation of VP4 peptide immunogens in a virus-like conformation

James T. Kelly, Giann Kerwin Y. Dellosa, Joseph Newman, Adel A. M. Mohamed, Julia Aniscenko, Sebastian L. Johnston, Jason Schnell, Tobias J. Tuthill

PLOS Pathogens: published July 16, 2026 | https://doi.org/10.1371/journal.ppat.1014416

The Sigma1 ER membrane receptor promotes structural protein folding and genome packaging of dengue virus

Riya Sarkar, Whitney Reid, Renaldo Sutanto, Andrew W. Tai, Billy Tsai

PLOS Pathogens: published July 16, 2026 | https://doi.org/10.1371/journal.ppat.1014347

Inflammasome activation dictates the efficacy of antimycobacterial activity of frontline TB drugs

Anjali Singh, Kanika Bisht, Garima Maurya, Nidhi Yadav, Ranjan Nanda, Vivek Rao

PLOS Pathogens: published July 16, 2026 | https://doi.org/10.1371/journal.ppat.1014384

A novel penicillin-binding protein inhibitor with unprecedented intracellular activity eradicates multiple pathogenic bacteria

Kai-Xuan Guo, Hong-Xia Hu, Zhen Cheng, Jian-Dong Zhang, Feng-Dong Zhu, Ying-Lei Zhang, Chao-Yue Guo, Kai-Xin Wu, Guo-Hua Cai, Hong-Rong Hong, Xiao-Yu Wan, Xu Yan, Wei Chen, Xuan Liang, Long-Chuan Duan, Huan-Chun Chen, Zheng-Fei Liu

PLOS Pathogens: published July 16, 2026 | https://doi.org/10.1371/journal.ppat.1014242

Callitrichine herpesvirus 3 in the common marmoset is a model of Epstein-Barr virus infection and associated lymphoma

Stacey L. Piotrowski, Xiaofan Li, Caitlin E. Fitzpatrick, Allison Tucker, Amanda Lee, Emily Leibovitch, Maria Chiara G. Monaco, Anna K. Grosskopf, Rose Peterson, Jennifer E. Dwyer, Andrew Warner, Matthew F. Starost, R. Mark Simpson, Stacey J. Sukoff Rizzo, Afonso C. Silva, Krystal Allen-Worthington, Heather Narver, Laurie T. Krug, Steven Jacobson

PLOS Pathogens: published July 17, 2026 | https://doi.org/10.1371/journal.ppat.1014450

The vesicular stomatitis virus matrix protein promotes FACT subunit depletion to suppress the FEAR pathway

Emily A. Rex, Dahee Seo, Aaron Embry, Neal M. Alto, Don B. Gammon

PLOS Pathogens: published July 17, 2026 | https://doi.org/10.1371/journal.ppat.1014430

Auxin biosynthesis and signaling drive virulence and plant adaptation in Dickeya dadantii

Amalia Roca, Saray Santamaría-Hernando, Zulema Udaondo, Juan J. Cabrera, Patricia Godoy, Ana Nogueira, Emilia López-Solanilla, Miguel A. Matilla

PLOS Pathogens: published July 17, 2026 | https://doi.org/10.1371/journal.ppat.1014429

m⁶A RNA methylation modulates IFN-γ-stimulated intestinal epithelial cell-intrinsic antiparasitic defense

Chansorena Pok, Ai-Yu Gong, Marion L. Graham, Shuhong Wang, Silu Deng, Zinat Sharmin, Eugene Lu, Guoqing Lu, Chuan He, Xian-Ming Chen

PLOS Pathogens: published July 20, 2026 | https://doi.org/10.1371/journal.ppat.1014442

Structural and evolutionary insights into DAF-12 interactions with transcriptional coactivators in parasitic nematodes

Manon Mallet, Yéléna Martin, João E. Carvalho, Eva Guchen, Remy Betous, Cherine Bechara, Anne Lespine, Michael Schubert, William Bourguet, Albane le Maire

PLOS Pathogens: published July 20, 2026 | https://doi.org/10.1371/journal.ppat.1014073

Quercetin, a flavonoid, suppresses viral proliferation by interfering with the ubiquitin transfer from E1 to E2 enzymes

Hanbo Li, Yu Li, Bowen Yin, Xinming Zhang, Zheng Xu, Changxu Song, Kang Li, Ling Tian

PLOS Pathogens: published July 20, 2026 | https://doi.org/10.1371/journal.ppat.1014425

Fibrillarin-mediated 2’-O-methylation serves as a translation brake on uncapped enterovirus RNA

Kui Zhang, Xuliu Zhou, Baocheng Yu, Xiang Guo, Li Zuo, Lishi Liu, Zhen Chen, Xueyan Zhang, Haojie Hao, Huanzhou Xu, Fang Huang, Wuxiang Guan, Haibin Liu

PLOS Pathogens: published July 20, 2026 | https://doi.org/10.1371/journal.ppat.1014455

Cdc42 and Rac2 act through the formin-like Frl/FMNL to control lamellocyte shape and encapsulation of parasitoid wasp eggs in Drosophila

Darius Molitor, Hermann Schillers, Sven Bogdan

PLOS Pathogens: published July 20, 2026 | https://doi.org/10.1371/journal.ppat.1014440

An emergent biofilm program from inactivation of Candida albicans master regulators Efg1 and Ndt80

Eunsoo Do, Robert Zarnowski, David R. Andes, Aaron P. Mitchell

PLOS Pathogens: published July 20, 2026 | https://doi.org/10.1371/journal.ppat.1014469

Environmental drivers of low vaccine responsiveness in a lab-to-wild rodent model

Simon A. Babayan, Saudamini Venkatesan, Jessica L. Hall, Ewan W. Smith, Amy R. Sweeny, Amy B. Pedersen

PLOS Pathogens: published July 21, 2026 | https://doi.org/10.1371/journal.ppat.1013647

A single DNA methylation site regulates cell fate during Clostridioides difficile sporulation

Pola Kuhn, John W. Ribis, Mi Ni, Gang Fang, Aimee Shen

PLOS Pathogens: published July 23, 2026 | https://doi.org/10.1371/journal.ppat.1013845

Longitudinal study of a rodent invasion reveals shifts in host pathogen interactions

Andrew McManus, Maxime Galan, Nathalie Charbonnel, Celia Holland, Vincent Sluydts, Annetta Zintl, Peter Stuart

PLOS Pathogens: published July 23, 2026 | https://doi.org/10.1371/journal.ppat.1014349

Repurposing screens reveal a role for PKCη and NF1 in SARS-CoV-2 infection

Jorge A. Acuña, Jesse Miller, Smita Bhutda, Kasirajan Ayyanathan, Brinda Kamalia, Kanupriya Whig, David Nguyen, Yongqing Zhu, Benoît Laleu, Timothy Wells, Kirandeep Samby, Andrew Pekosz, David C. Schultz, Sara Cherry

PLOS Pathogens: published July 23, 2026 | https://doi.org/10.1371/journal.ppat.1014417

The lipid A acylation pattern of Coxiella burnetii prevents detection and clearance by the non-canonical inflammasome in primary murine macrophages

Manuela Szperlinski, Faiza Asghar, František Csicsay, Elias Schermuly, Roland Lang, Ľudovit Škultéty, Christian Berens, Katja Mertens-Scholz, Anja Lührmann

PLOS Pathogens: published July 24, 2026 | https://doi.org/10.1371/journal.ppat.1014465

Broad and durable protection against SARS-CoV-2 and SARS-CoV by an intranasal chimpanzee adenovirus vaccine expressing tandem RBDs and nucleocapsid

Yaping Liu, Runhong Zhou, Tian Zhao, Ruoke Wang, Kun Zhu, Junxian Hong, Ziqing Yang, Qianqian Yang, Yuqing Lei, Yang Bai, Jing Wei, Peng Chen, Xinyu Fan, Qi Zhang, Xuanling Shi, Peng Liu, Zhiwei Chen, Linqi Zhang

PLOS Pathogens: published July 24, 2026 | https://doi.org/10.1371/journal.ppat.1014436

IRES-like element-mediated translation of vsp1S4(-) suppresses BmCPV replication via RNAi antagonism

Xialing Chen, Qian Teng, Haoni Xue, Lixuan Li, Xiaoyan Du, Min Zhu, Xing Zhang, Chengliang Gong, Xiaolong Hu

PLOS Pathogens: published July 24, 2026 | https://doi.org/10.1371/journal.ppat.1014402

Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants

Robert T. Steinbock, Orlando B. Scudero, Joseph M. Dybas, Amber R. N. Abbott, Katarzyna Kulej, Richard Lauman, Holly Chan, Eva L. Agostino, Namrata Kumar, Cameron Stone, Skyler Briggs, Nicholas A. Parenti, Yize Li, James M. Burke, Susan R. Weiss, Alexander M. Price, Matthew D. Weitzman

PLOS Pathogens: published July 24, 2026 | https://doi.org/10.1371/journal.ppat.1014452

Selection profiles in RNA viruses reflect the characteristics of viruses more than individual proteins

Laura Muñoz-Baena, Hugo G. Castelán-Sánchez, Sareh Bagherichimeh, Paula Magbor, Jorge Rojas-Vargas, Amjad Khan, Abayomi S. Olabode, Art F. Y. Poon

PLOS Pathogens: published July 24, 2026 | https://doi.org/10.1371/journal.ppat.1014457

Phosphatidylinositol-4-phosphate signaling regulates dense granule biogenesis and maturation in Toxoplasma gondii

Angela Arabiotorre, Megan Formanowicz, Vytas A. Bankaitis, Aby Grabon

PLOS Pathogens: published July 24, 2026 | https://doi.org/10.1371/journal.ppat.1014451

EV-B 3D polymerase remodels viral populations through 5′UTR recombination to subvert cardiac antiviral innate immunity

Marie Glenet, Laetitia Heng, Anne-Laure Lebreil, Paul-Antoine Gretteau, Yohan Nguyen, Fatma Berri, Laurent Andreoletti

PLOS Pathogens: published July 24, 2026 | https://doi.org/10.1371/journal.ppat.1014441

The axonal transport velocity of prions is independent of prion formation

Sam M. Koshy, Jay Hrdlicka, Michael G. Nichols, Anthony S. Stender, Jack H. Taylor, Joaquín Castilla, Jason C. Bartz

PLOS Pathogens: published July 24, 2026 | https://doi.org/10.1371/journal.ppat.1014456

VRK3 promotes KSHV infection by suppressing the antiviral type I interferon response

Caroline J. Yu, Blossom Damania

PLOS Pathogens: published July 27, 2026 | https://doi.org/10.1371/journal.ppat.1014400

A broad-spectrum phage-encoded mechanism to disarm bacterial type IV filaments

Nathan A. Roberge, Paankhi Dave, Véronique Taylor, Taylor J. Ellison, Callum Myers, Courtney K. Ellison, Karen L. Maxwell, Lori L. Burrows

PLOS Pathogens: published July 27, 2026 | https://doi.org/10.1371/journal.ppat.1014478

Noncanonical bactericidal activity of teleost type I interferon is conferred by a membrane-targeting C-terminal peptide

Han Zhang, Ying Wu, Xiaoyuan Zheng, Ziyu Wang, Chen Zhang, Zhenjie Cao, Jingqun Ao, Yongcan Zhou, Yun Sun

PLOS Pathogens: published July 28, 2026 | https://doi.org/10.1371/journal.ppat.1014419

A novel stress response pathway mediates biofilm architecture in Pseudomonas aeruginosa

Ainelen Piazza, Catriona M. A. Thompson, Govind Chandra, Harshanie Dasanayaka, Gerhard Saalbach, Carlo Martins, Eleftheria Trampari, Mark A. Webber, Freya Harrison, Jacob G. Malone

PLOS Pathogens: published July 28, 2026 | https://doi.org/10.1371/journal.ppat.1013832

Biofilm formation during pneumococcal carriage imprints naturally acquired humoral immunity

Jessica R. Lane, Henry Mauser, Silvia E. Santana-Krimskaya, Vahini S. Konda, Andrew DePass, Giuseppe Ercoli, Federico I. Prokopczuk, Mohammed Mohasin, Adonis D’Mello, Hervé Tettelin, Jeremy S. Brown, Luis F. Reyes, Carlos J. Orihuela

PLOS Pathogens: published July 28, 2026 | https://doi.org/10.1371/journal.ppat.1013826

A TCER-1-siRNA regulatory axis suppresses antibacterial innate immunity in C. elegans

Nikki Naim, Francis R.G. Amrit, Mayur N. Devare, Guled A. Osman, Laura L. Bahr, Hannah Henry, Brooke E. Montgomery, Spencer M. Kuhn, Taiowa A. Montgomery, Arjumand Ghazi

PLOS Pathogens: published July 28, 2026 | https://doi.org/10.1371/journal.ppat.1013972

Host hybridization enabled the emergence of a reassorted hantavirus lineage

Anton Labutin, Nadine Ritter, Guiscard Seebohm, Gerald Heckel

PLOS Pathogens: published July 28, 2026 | https://doi.org/10.1371/journal.ppat.1014458

Non-human primate LIBRA-Seq accelerates neutralizing antibody discovery in RM vaccinated against HIV-1

Christopher T. Edwards, Aaron D. Silva-Trenkle, Anusmita Sahoo, Kendra Cruickshank, Sydney Nelson, Stacey A. Lapp, Nagarajan Raju, Thang Ton, Amanda Metz, Emily McGhee, Faith A. Mbadugha, Tysheena P. Charles, Ankur Saini, Kiran Gill, Kathryn L. Pellegrini, Rui Kong, Jens Wrammert, Amit A. Upadhyay, Cynthia A. Derdeyn, Rama Rao Amara, Gabriel Kwong, Steven E. Bosinger

PLOS Pathogens: published July 28, 2026 | https://doi.org/10.1371/journal.ppat.1013831

Bacillus thuringiensis pathogenicity islands encode regulatory circuits controlling insecticidal Cry toxin expression during vegetative growth

Bowen Zhang, Zhiyu Liu, Hang Zhang, Alejandra Bravo, Mario Soberón, Jinshui Zheng, Ming Sun, Kai Wang, Fuping Song, Donghai Peng

PLOS Pathogens: published July 29, 2026 | https://doi.org/10.1371/journal.ppat.1014476

Deep phenotypic profiling uncovers cryptic effects of antifilarial drugs

Kaetlyn T. Ryan, Nathalie Dinguirard, Clair R. Henthorn, Nicolas J. Wheeler, Mostafa Zamanian

PLOS Pathogens: published July 29, 2026 | https://doi.org/10.1371/journal.ppat.1014485

FIKK1, a member of the FIKK kinase family, phosphorylates VAR2CSA and regulates adhesion of Plasmodium falciparum-infected erythrocytes to the placental receptor CSA

Benoît Gamain, Jean-Philippe Semblat, Heledd Eavis, Hugo Belda, Romain Hamelin, Clara-Eva Paquereau, Christian Doerig, Moritz Treeck, Dominique Dorin-Semblat

PLOS Pathogens: published July 29, 2026 | https://doi.org/10.1371/journal.ppat.1014108

Post-COVID impairment of T cell responses to community-acquired pathogens can be modified by activating cellular metabolism

Daniel D. Carroll, Kamacay Cira, Jack Archer, Jason Shapiro, Hardik Shah, Ue-Yu Pen, David Tieri, Lucia Leonor, Neda D. Roofchayee, Samantha S. Yee, Marc Wahab, Igor J. Koralnik, John C. Alverdy, Arjun S. Raman, Lavanya Visvabharathy

PLOS Pathogens: published July 30, 2026 | https://doi.org/10.1371/journal.ppat.1013860

An orally available PfPKG inhibitor blocks Plasmodium’s infection of the liver

Hanna Dhiyebi, Aminata Mbaye, Anusha Thaniana, John Gilleran, Tyler Eck, Kutub Ashraf, Karl Kudyba, Howard Fan, Steve Seibold, Kevin P. Battaile, John Siekierka, Evan Johnson, Alison Roth, Amy De Rocher, Scott Lovell, Edward B. Miller, Jacques Y. Roberge, Purnima Bhanot

PLOS Pathogens: published July 30, 2026 | https://doi.org/10.1371/journal.ppat.1014322

DNA oligonucleotides block viral entry of SARS-CoV-2 Omicron variants

Jorge A. Acuña, Benjamin Gabriel, Kasirajan Ayyanathan, Jesse Miller, Yue Li, Kanupriya Whig, Yongqing Zhu, Marisa McGrath, Peter Hewins, Kellie Ann Jurado, Matthew B. Frieman, David C. Schultz, Sara Cherry

PLOS Pathogens: published July 30, 2026 | https://doi.org/10.1371/journal.ppat.1014461

ddOTs: A multiplexed quantitative ddPCR approach for resolving overlapping hepatitis B virus transcripts to decipher cccDNA-driven transcription

Nazim Sarica, Oceane Lopez, João Diogo Dias, Victor Boschetti, Irene Meki, Basile Jay, Gael Petitjean, David Durantel, Christine Neuveut

PLOS Pathogens: published July 30, 2026 | https://doi.org/10.1371/journal.ppat.1014464

The residue 86 of the Getah virus E2 glycoprotein mediates both glycosaminoglycan- and LDLR-dependent infection

Xiangshu Qiu, Rongguang Lu, Jiaxin Tian, He Zhang, Jiyong Zhou, Mengsi Sun, Xinyu Cao, Xiangyu Zhu, Bocheng Liu, Qihui Yu, Yuanyuan Li, Hualei Wang, Ningyi Jin, Huijun Lu, Ning Shi

PLOS Pathogens: published July 31, 2026 | https://doi.org/10.1371/journal.ppat.1014453

Correction: Staphylococcus aureus adapts to the host nutritional environment by coordinating the activity of central metabolic enzymes

The PLOS Pathogens Staff

PLOS Pathogens: published July 6, 2026 | https://doi.org/10.1371/journal.ppat.1014398

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Correction: Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir

The PLOS Pathogens Staff

PLOS Pathogens: published July 6, 2026 | https://doi.org/10.1371/journal.ppat.1014399

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Retraction: Genome-wide characterization of Src Homology-3 (SH3) domain-containing proteins in the development and pathogenicity of Fusarium graminearum

The PLOS Pathogens Editors

PLOS Pathogens: published July 20, 2026 | https://doi.org/10.1371/journal.ppat.1014445

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Editorial Note: The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication

The PLOS Pathogens Editors

PLOS Pathogens: published July 13, 2026 | https://doi.org/10.1371/journal.ppat.1014413

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The durable resistance gene Tm-2² remains partially resistant to tomato brown rugose fruit virus

Shaokang Zhang, Mark A. Bernards, Aiming Wang

PLOS Pathogens: published July 17, 2026 | https://doi.org/10.1371/journal.ppat.1014380

Natural Killer Cell Granule Protein (NKG7) promotes the development of vaccine-induced anti-fungal Th1 cells

Marcel Wüthrich, Cleison Ledesma Taira, Lucas dos Santos Dias, Xin He, Sarah Lichtenberger, Bruce S. Klein

PLOS Pathogens: published July 31, 2026 | https://doi.org/10.1371/journal.ppat.1014187