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Table of Contents

April 2022

Immunofluorescence staining of Hela cell infected with Salmonella Paratyphi A. Composition of three images showing intracellular Salmonella Paratyphi A (blue), flagella filaments (red) and LAMP1 (green).

Image Credit: Felix Scharte and Michael Hensel, Abt. Mikrobiologie, Universität Osnabrück. Both are coauthors of the paper and own the the copyright for this image.

Pearls

Is Candida albicans an opportunistic oncogenic pathogen?

Ahmed S. Sultan, Vasileios Ionas Theofilou, Areej Alfaifi, Daniel Montelongo-Jauregui, Mary-Ann Jabra-Rizk

Exploitation of the Mediator complex by viruses

Joel Rovnak, Sandra L. Quackenbush

Review

The FAR protein family of parasitic nematodes

Sophia C. Parks, Susan Nguyen, Martin J. Boulanger, Adler R. Dillman

Research Articles

Long-read sequencing reveals complex patterns of wraparound transcription in polyomaviruses

Jason Nomburg, Wei Zou, Thomas C. Frost, Chandreyee Datta, Shobha Vasudevan, Gabriel J. Starrett, Michael J. Imperiale, Matthew Meyerson, James A. DeCaprio

Early IL-17A production helps establish Mycobacterium intracellulare infection in mice

Bock-Gie Jung, Buka Samten, Kristin Dean, Richard J. Wallace Jr., Barbara A. Brown-Elliott, Torry Tucker, Steven Idell, Julie V. Philley, Ramakrishna Vankayalapati

High-resolution structures of malaria parasite actomyosin and actin filaments

Juha Vahokoski, Lesley J. Calder, Andrea J. Lopez, Justin E. Molloy, Inari Kursula, Peter B. Rosenthal

NK cells and monocytes modulate primary HTLV-1 infection

Ramona Moles, Sarkis Sarkis, Veronica Galli, Maria Omsland, Maria Artesi, Massimiliano Bissa, Katherine McKinnon, Sophia Brown, Vincent Hahaut, Robyn Washington-Parks, Joshua Welsh, David J. Venzon, Anna Gutowska, Melvin N. Doster, Matthew W. Breed, Kristin E. Killoran, Joshua Kramer, Jennifer Jones, Marcin Moniuszko, Anne Van den Broeke, Cynthia A. Pise-Masison, Genoveffa Franchini

PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence

Guangwen Wang, Yuhui Zhao, Yuan Zhou, Li Jiang, Libin Liang, Fandi Kong, Ya Yan, Xuyuan Wang, Yihan Wang, Xia Wen, Xianying Zeng, Guobin Tian, Guohua Deng, Jianzhong Shi, Liling Liu, Hualan Chen, Chengjun Li

Coupled small molecules target RNA interference and JAK/STAT signaling to reduce Zika virus infection in Aedes aegypti

Chasity E. Trammell, Gabriela Ramirez, Irma Sanchez-Vargas, Laura A. St Clair, Oshani C. Ratnayake, Shirley Luckhart, Rushika Perera, Alan G. Goodman

Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to intracellular S. Typhimurium

Helit Cohen, Claire Hoede, Felix Scharte, Charles Coluzzi, Emiliano Cohen, Inna Shomer, Ludovic Mallet, Sébastien Holbert, Remy Felix Serre, Thomas Schiex, Isabelle Virlogeux-Payant, Guntram A. Grassl, Michael Hensel, Hélène Chiapello, Ohad Gal-Mor

D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytes

Yun-Jong Park, David Acosta, Russell Vassell, Juanjie Tang, Surender Khurana, Carol D. Weiss, Hana Golding, Marina Zaitseva

The WOPR family protein Ryp1 is a key regulator of gene expression, development, and virulence in the thermally dimorphic fungal pathogen Coccidioides posadasii

M. Alejandra Mandel, Sinem Beyhan, Mark Voorhies, Lisa F. Shubitz, John N. Galgiani, Marc J. Orbach, Anita Sil

Enterococcus faecalis alters endo-lysosomal trafficking to replicate and persist within mammalian cells

Ronni A. G. da Silva, Wei Hong Tay, Foo Kiong Ho, Frederick Reinhart Tanoto, Kelvin K. L. Chong, Pei Yi Choo, Alexander Ludwig, Kimberly A. Kline

Geminivirus C4 proteins inhibit GA signaling via prevention of NbGAI degradation, to promote viral infection and symptom development in N. benthamiana

Pengbai Li, Liuming Guo, Xinyuan Lang, Mingjun Li, Gentu Wu, Rui Wu, Lyuxin Wang, Meisheng Zhao, Ling Qing

Spatial transcriptomics reveals antiparasitic targets associated with essential behaviors in the human parasite Brugia malayi

Paul M. Airs, Kathy Vaccaro, Kendra J. Gallo, Nathalie Dinguirard, Zachary W. Heimark, Nicolas J. Wheeler, Jiaye He, Kurt R. Weiss, Nathan E. Schroeder, Jan Huisken, Mostafa Zamanian

The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model

Jana Holubova, Ondrej Stanek, Attila Juhasz, Illiassou Hamidou Soumana, Peter Makovicky, Peter Sebo

Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques

Malika Aid, Samuel J. Vidal, Cesar Piedra-Mora, Sarah Ducat, Chi N. Chan, Stephen Bondoc, Alessandro Colarusso, Carly E. Starke, Michael Nekorchuk, Kathleen Busman-Sahay, Jacob D. Estes, Amanda J. Martinot, Dan H. Barouch

Identification of a two-component regulatory system involved in antimicrobial peptide resistance in Streptococcus pneumoniae

Aissatou Maty Diagne, Anaïs Pelletier, Claire Durmort, Agathe Faure, Kerstin Kanonenberg, Céline Freton, Adeline Page, Frédéric Delolme, Jaroslav Vorac, Sylvain Vallet, Laure Bellard, Corinne Vivès, Franck Fieschi, Thierry Vernet, Patricia Rousselle, Sébastien Guiral, Christophe Grangeasse, Jean-Michel Jault, Cédric Orelle

Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins

Salla Mattola, Kari Salokas, Vesa Aho, Elina Mäntylä, Sami Salminen, Satu Hakanen, Einari A. Niskanen, Julija Svirskaite, Teemu O. Ihalainen, Kari J. Airenne, Minna Kaikkonen-Määttä, Colin R. Parrish, Markku Varjosalo, Maija Vihinen-Ranta

Detailed analysis of antibody responses to SARS-CoV-2 vaccination and infection in macaques

Alexandra C. Willcox, Kevin Sung, Meghan E. Garrett, Jared G. Galloway, Jesse H. Erasmus, Jennifer K. Logue, David W. Hawman, Helen Y. Chu, Kim J. Hasenkrug, Deborah H. Fuller, Frederick A. Matsen IV, Julie Overbaugh

Candida albicans commensalism in the oral mucosa is favoured by limited virulence and metabolic adaptation

Christina Lemberg, Kontxi Martinez de San Vicente, Ricardo Fróis-Martins, Simon Altmeier, Van Du T. Tran, Sarah Mertens, Sara Amorim-Vaz, Laxmi Shanker Rai, Christophe d’Enfert, Marco Pagni, Dominique Sanglard, Salomé LeibundGut-Landmann

A newly emerging alphasatellite affects banana bunchy top virus replication, transcription, siRNA production and transmission by aphids

Valentin Guyot, Rajendran Rajeswaran, Huong Cam Chu, Chockalingam Karthikeyan, Nathalie Laboureau, Serge Galzi, Lyna F. T. Mukwa, Mart Krupovic, P. Lava Kumar, Marie-Line Iskra-Caruana, Mikhail M. Pooggin

Host diversity and behavior determine patterns of interspecies transmission and geographic diffusion of avian influenza A subtypes among North American wild reservoir species

Joseph T. Hicks, Kimberly Edwards, Xueting Qiu, Do-Kyun Kim, James E. Hixson, Scott Krauss, Richard J. Webby, Robert G. Webster, Justin Bahl

The nuclear lamina binds the EBV genome during latency and regulates viral gene expression

Lisa Beatrice Caruso, Rui Guo, Kelsey Keith, Jozef Madzo, Davide Maestri, Sarah Boyle, Jason Wasserman, Andrew Kossenkov, Benjamin E. Gewurz, Italo Tempera

Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor

Oded Danziger, Roosheel S. Patel, Emma J. DeGrace, Mikaela R. Rosen, Brad R. Rosenberg

Mycobacterium tuberculosis requires SufT for Fe-S cluster maturation, metabolism, and survival in vivo

Ashutosh Tripathi, Kushi Anand, Mayashree Das, Ruchika Annie O’Niel, Sabarinath P. S, Chandrani Thakur, Raghunatha Reddy R. L., Raju S. Rajmani, Nagasuma Chandra, Sunil Laxman, Amit Singh

Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but moderately reduced lung inflammation

Koen K. A. Van Rompay, Katherine J. Olstad, Rebecca L. Sammak, Joseph Dutra, Jennifer K. Watanabe, Jodie L. Usachenko, Ramya Immareddy, Jamin W. Roh, Anil Verma, Yashavanth Shaan Lakshmanappa, Brian A. Schmidt, Clara Di Germanio, Nabeela Rizvi, Hongwei Liu, Zhong-Min Ma, Mars Stone, Graham Simmons, Larry J. Dumont, A. Mark Allen, Sarah Lockwood, Rachel E. Pollard, Rafael Ramiro de Assis, JoAnn L. Yee, Peter B. Nham, Amir Ardeshir, Jesse D. Deere, Aarti Jain, Philip L. Felgner, Lark L. Coffey, Smita S. Iyer, Dennis J. Hartigan-O’Connor, Michael P. Busch, J. Rachel Reader

Profiling metabolites and lipoproteins in COMETA, an Italian cohort of COVID-19 patients

Veronica Ghini, Gaia Meoni, Lorenzo Pelagatti, Tommaso Celli, Francesca Veneziani, Fabrizia Petrucci, Vieri Vannucchi, Laura Bertini, Claudio Luchinat, Giancarlo Landini, Paola Turano

Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and influence the host response

Evgeniya V. Shmeleva, Mercedes Gomez de Agüero, Josef Wagner, Anton J. Enright, Andrew J. Macpherson, Brian J. Ferguson, Geoffrey L. Smith

Blood vessel occlusion by Cryptococcus neoformans is a mechanism for haemorrhagic dissemination of infection

Josie F. Gibson, Aleksandra Bojarczuk, Robert J. Evans, Alfred Alinafe Kamuyango, Richard Hotham, Anne K. Lagendijk, Benjamin M. Hogan, Philip W. Ingham, Stephen A. Renshaw, Simon A. Johnston

Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection

Patricia Bartsch, Christoph Kilian, Malte Hellmig, Hans-Joachim Paust, Alina Borchers, Amirrtavarshni Sivayoganathan, Leon Enk, Yu Zhao, Nikhat Shaikh, Henning Büttner, Milagros N. Wong, Victor G. Puelles, Thorsten Wiech, Richard Flavell, Tobias B. Huber, Jan-Eric Turner, Stefan Bonn, Samuel Huber, Nicola Gagliani, Hans-Willi Mittrücker, Holger Rohde, Ulf Panzer, Christian F. Krebs

Identification of functionally important domains of human cytomegalovirus gO that act after trimer binding to receptors

Andrea Chin, Jing Liu, Theodore Jardetzky, David C. Johnson, Adam Vanarsdall

Astrovirus-induced epithelial-mesenchymal transition via activated TGF-β increases viral replication

Virginia Hargest, Theresa Bub, Geoffrey Neale, Stacey Schultz-Cherry

Reconstitution of EBV-directed T cell immunity by adoptive transfer of peptide-stimulated T cells in a patient after allogeneic stem cell transplantation for AITL

María Fernanda Lammoglia Cobo, Julia Ritter, Regina Gary, Volkhard Seitz, Josef Mautner, Michael Aigner, Simon Völkl, Stefanie Schaffer, Stephanie Moi, Anke Seegebarth, Heiko Bruns, Wolf Rösler, Kerstin Amann, Maike Büttner-Herold, Steffen Hennig, Andreas Mackensen, Michael Hummel, Andreas Moosmann, Armin Gerbitz

HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys

Brian Moldt, Abishek Chandrashekar, Erica N. Borducchi, Joseph P. Nkolola, Heather Stephenson, Mark Nagel, Magdeleine Hung, Joshua Goldsmith, Craig S. Pace, Brian Carr, Nathan D. Thomsen, Wade S. Blair, Romas Geleziunas, Dan H. Barouch

Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells

Jillian A. Bristol, Joshua Brand, Makoto Ohashi, Mark R. Eichelberg, Alejandro Casco, Scott E. Nelson, Mitchell Hayes, James C. Romero-Masters, Dana C. Baiu, Jenny E. Gumperz, Eric C. Johannsen, Huy Q. Dinh, Shannon C. Kenney

Salmonella enterica serovar Typhimurium chitinases modulate the intestinal glycome and promote small intestinal invasion

Jason R. Devlin, William Santus, Jorge Mendez, Wenjing Peng, Aiying Yu, Junyao Wang, Xiomarie Alejandro-Navarreto, Kaitlyn Kiernan, Manmeet Singh, Peilin Jiang, Yehia Mechref, Judith Behnsen

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A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant

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Formal Comment