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Table of Contents

June 2024

Dormant Pseudomonas aeruginosa bacteria (green) colonize tissues as single cells that can be observed here through the Drosophila cuticle, following their escape from the digestive tract in a newly developed latent infection model. They are tolerant to antibiotic treatments and retain their potential for virulence. Melanization, an arthropod-specific host defense plays a key role in the establishment of latency. This study underscores the plasticity of P. aeruginosa behavior in vivo depending on the infection route. Chen et al

Image Credit: Jing Chen

Editorial

PLOS Pathogens expanding horizons

Julia Squarr, Rebecca Kirk, Alexander E. Gorbalenya, Michael Malim

Pearls

The emergence of bacterial prions

Rafael Giraldo

How can we escape the ESKAPEs: Antimicrobial resistance mechanisms and what lies ahead?

Jessica B. Kelly, Aaron C. Nolan, Merve S. Zeden

Current and emerging issues in dermatophyte infections

Sarah Dellière, Arnaud Jabet, Alireza Abdolrasouli

Reactive astrocytes in prion diseases: Friend or foe?

Natallia Makarava, Rajesh Kushwaha, Ilia V. Baskakov

A new landscape for malaria vaccine development

Alexander J. Laurenson, Matthew B. Laurens

Review

Functions and mechanisms of A-to-I RNA editing in filamentous ascomycetes

Zeyi Wang, Zhuyun Bian, Diwen Wang, JinRong Xu

Research Articles

Elucidating the spatio-temporal dynamics of the Plasmodium falciparum basal complex

Alexander A. Morano, Ilzat Ali, Jeffrey D. Dvorin

The BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection

Kaitlyn Speckhart, Jeongjoon Choi, Daniel DiMaio, Billy Tsai

The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity

Chen Yang, Chen-Yu Wang, Qiao-Yun Long, Zhuo Cao, Ming-Liang Wei, Shan-Bo Tang, Xiang Lin, Zi-Qi Mu, Yong Xiao, Ming-Kai Chen, Min Wu, Lian-Yun Li

Pulmonary inflammation and viral replication define distinct clinical outcomes in fatal cases of COVID-19

Keyla S. G. de Sá, Luana A. Amaral, Tamara S. Rodrigues, Camila C. S. Caetano, Amanda Becerra, Sabrina S. Batah, Felipe T. Lopes, Isadora M. de Oliveira, Letícia S. Lopes, Leticia Almeida, Caroline M. Mota, Samuel Oliveira, Danilo T. Wada, Marcel Koenigkam-Santos, Ronaldo B. Martins, Roberta R. C. Rosales, Eurico Arruda, Alexandre T. Fabro, Dario S. Zamboni

Molecular and structural basis of oligopeptide recognition by the Ami transporter system in pneumococci

Martín Alcorlo, Mohammed R. Abdullah, Leif Steil, Francisco Sotomayor, Laura López-de Oro, Sonia de Castro, Sonsoles Velázquez, Thomas P. Kohler, Elisabet Jiménez, Ana Medina, Isabel Usón, Lance E. Keller, Jessica L. Bradshaw, Larry S. McDaniel, María-José Camarasa, Uwe Völker, Sven Hammerschmidt, Juan A. Hermoso

Deficiency in non-classical major histocompatibility class II-like molecule, H2-O confers protection against Staphylococcus aureus in mice

Emily Cullum, Yunys Perez-Betancourt, Miaomiao Shi, Eirinaios Gkika, Olaf Schneewind, Dominique Missiakas, Tatyana Golovkina

Heightened Epstein-Barr virus immunity and potential cross-reactivities in multiple sclerosis

Olivia G. Thomas, Tracey A. Haigh, Deborah Croom-Carter, Alison Leese, Yolanda Van Wijck, Michael R. Douglas, Alan Rickinson, Jill M. Brooks, Graham S. Taylor

Temporal regulation of MDA5 inactivation by Caspase-3 dependent cleavage of 14-3-3η

Yun-Jui Chan, Nien-Tzu Liu, Fu Hsin, Jia-Ying Lu, Jing-Yi Lin, Helene Minyi Liu

Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics

Punyawee Dulyayangkul, Thomas Beavis, Winnie W. Y. Lee, Robbie Ardagh, Frances Edwards, Fergus Hamilton, Ian Head, Kate J. Heesom, Oliver Mounsey, Marek Murarik, Peechanika Pinweha, Carlos Reding, Naphat Satapoomin, John M. Shaw, Yuiko Takebayashi, Catherine L. Tooke, James Spencer, Philip B. Williams, Matthew B. Avison

The histone methyltransferase SETD2 regulates HIV expression and latency

Cameron R. Bussey-Sutton, Airlie Ward, Joshua A. Fox, Anne-Marie W. Turner, Jackson J. Peterson, Ann Emery, Arturo R. Longoria, Ismael Gomez-Martinez, Corbin Jones, Austin Hepperla, David M. Margolis, Brian D. Strahl, Edward P. Browne

IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission

Arun Prakash, Florence Fenner, Biswajit Shit, Tiina S. Salminen, Katy M. Monteith, Imroze Khan, Pedro F. Vale

Herpes simplex virus spreads rapidly in human foreskin, partly driven by chemokine-induced redistribution of Nectin-1 on keratinocytes

Hafsa Rana, Naomi R. Truong, Blake Johnson, Heeva Baharlou, Jason J. Herbert, Sasikaran Kandasamy, Robert Goddard, Ralph C. Cohen, Michael Wines, Najla Nasr, Andrew N. Harman, Kirstie M. Bertram, Kerrie J. Sandgren, Anthony L. Cunningham

The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine

Xiaorui Chen, Arpita Mohapatra, Hong Thuy Vy Nguyen, Lisa Schimanski, Tiong Kit Tan, Pramila Rijal, Cheng-Pin Chen, Shu-Hsing Cheng, Wen-Hsin Lee, Yu-Chi Chou, Alain R. Townsend, Che Ma, Kuan-Ying A. Huang

Pathogenic differences of cynomolgus macaques after Taï Forest virus infection depend on the viral stock propagation

Paige Fletcher, Chad S. Clancy, Kyle L. O’Donnell, Brianna M. Doratt, Delphine C. Malherbe, Joseph F. Rhoderick, Friederike Feldmann, Patrick W. Hanley, Ayato Takada, Ilhem Messaoudi, Andrea Marzi

Natural variation in infection specificity of Caenorhabditis briggsae isolates by two RNA viruses

Cigdem Alkan, Gautier Brésard, Lise Frézal, Aurélien Richaud, Albane Ruaud, Gaotian Zhang, Marie-Anne Félix

Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice

Daniel M. Gatti, Anna L. Tyler, J Matthew Mahoney, Gary A. Churchill, Bulent Yener, Deniz Koyuncu, Metin N. Gurcan, MK Khalid Niazi, Thomas Tavolara, Adam Gower, Denise Dayao, Emily McGlone, Melanie L. Ginese, Aubrey Specht, Anas Alsharaydeh, Philipe A. Tessier, Sherry L. Kurtz, Karen L. Elkins, Igor Kramnik, Gillian Beamer

Arboviruses antagonize insect Toll antiviral immune signaling to facilitate the coexistence of viruses with their vectors

Dongsheng Jia, Guozhong Luo, Heran Guan, Tingting Yu, Xinyan Sun, Yu Du, Yiheng Wang, Hongyan Chen, Taiyun Wei

Temporal and spatial dynamics of Plasmodium falciparum clonal lineages in Guyana

Mathieu Vanhove, Philipp Schwabl, Collette Clementson, Angela M. Early, Margaret Laws, Frank Anthony, Célia Florimond, Luana Mathieu, Kashana James, Cheyenne Knox, Narine Singh, Caroline O. Buckee, Lise Musset, Horace Cox, Reza Niles-Robin, Daniel E. Neafsey

Antiviral activity of intracellular nanobodies targeting the influenza virus RNA-polymerase core

Mélissa Bessonne, Jessica Morel, Quentin Nevers, Bruno Da Costa, Allison Ballandras-Colas, Florian Chenavier, Magali Grange, Alain Roussel, Thibaut Crépin, Bernard Delmas

Zinc-finger (ZiF) fold secreted effectors form a functionally diverse family across lineages of the blast fungus Magnaporthe oryzae

Juan Carlos De la Concepcion, Thorsten Langner, Koki Fujisaki, Xia Yan, Vincent Were, Anson Ho Ching Lam, Indira Saado, Helen J. Brabham, Joe Win, Kentaro Yoshida, Nicholas J. Talbot, Ryohei Terauchi, Sophien Kamoun, Mark J. Banfield

Wolbachia mediates crosstalk between miRNA and Toll pathways to enhance resistance to dengue virus in Aedes aegypti

Lingzhi She, Mengyi Shi, Ting Cao, Hao Yuan, Renke Wang, Weifeng Wang, Yueting She, Chaojun Wang, Qin Zeng, Wei Mao, Yalan Zhang, Yong Wang, Zhiyong Xi, Xiaoling Pan

Zn2+-dependent association of cysteine-rich protein with virion orchestrates morphogenesis of rod-shaped viruses

Ning Yue, Zhihao Jiang, Qinglin Pi, Meng Yang, Zongyu Gao, Xueting Wang, He Zhang, Fengtong Wu, Xuejiao Jin, Menglin Li, Ying Wang, Yongliang Zhang, Dawei Li

Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis

Kuo-Yao Tseng, Yu-Tsung Huang, Yu-Ting Huang, Yu-Ting Su, An-Ni Wang, Wen-Yen Weng, Cai-Ling Ke, Yu-Chiao Yeh, Jhih-Jie Wang, Shin-Hei Du, Zi-Qi Gu, Wei-Lin Chen, Ching-Hsuan Lin, Yu-Huan Tsai

Dissecting positive selection events and immunological drives during the evolution of adeno-associated virus lineages

Lirong Li, Runkuan Qin, Yunbo Liu, Yu-Shan Tseng, Weihan Zhang, Lin Yu, Mario Mietzsch, Xinkai Zou, Haizhou Liu, Guangwen Lu, Hongbo Hu, Robert Mckenna, Jinliang Yang, Yuquan Wei, Mavis Agbandje-Mckenna, Jiankun Hu, Lin Yang

Chlamydia trachomatis induces disassembly of the primary cilium to promote the intracellular infection

Roseleen Ekka, Abraham Gutierrez, Kirsten A. Johnson, Ming Tan, Christine Sütterlin

MicroRNA-focused CRISPR/Cas9 screen identifies miR-142 as a key regulator of Epstein-Barr virus reactivation

Yan Chen, Rodney P. Kincaid, Kelley Bastin, Devin N. Fachko, Rebecca L. Skalsky

CD56-mediated activation of human natural killer cells is triggered by Aspergillus fumigatus galactosaminogalactan

Linda Heilig, Fariha Natasha, Nora Trinks, Vishukumar Aimanianda, Sarah Sze Wah Wong, Thierry Fontaine, Ulrich Terpitz, Lea Strobel, François Le Mauff, Donald C. Sheppard, Sascha Schäuble, Oliver Kurzai, Kerstin Hünniger, Esther Weiss, Mario Vargas, P. Lynne Howell, Gianni Panagiotou, Sebastian Wurster, Hermann Einsele, Juergen Loeffler

Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

Camille N. Pierre, Lily E. Adams, Jaclyn S. Higgins, Kara Anasti, Derrick Goodman, Dieter Mielke, Sherry Stanfield-Oakley, John M. Powers, Dapeng Li, Wes Rountree, Yunfei Wang, Robert J. Edwards, S. Munir Alam, Guido Ferrari, Georgia D. Tomaras, Barton F. Haynes, Ralph S. Baric, Kevin O. Saunders

N-acetylglucosamine supplementation fails to bypass the critical acetylation of glucosamine-6-phosphate required for Toxoplasma gondii replication and invasion

María Pía Alberione, Víctor González-Ruiz, Olivier von Rohr, Serge Rudaz, Dominique Soldati-Favre, Luis Izquierdo, Joachim Kloehn

The role of socio-economic disparities in the relative success and persistence of SARS-CoV-2 variants in New York City in early 2021

Tetyana I. Vasylyeva, Jennifer L. Havens, Jade C. Wang, Elizabeth Luoma, Gabriel W. Hassler, Helly Amin, Steve Di Lonardo, Faten Taki, Enoma Omoregie, Scott Hughes, Joel O. Wertheim

Alpha-defensin binding expands human adenovirus tropism

Cheng Zhao, Jessica M. Porter, Phillip C. Burke, Niklas Arnberg, Jason G. Smith

Human cytomegalovirus deploys molecular mimicry to recruit VPS4A to sites of virus assembly

Benjamin G. Butt, Daniela Fischer, Alison R. Rep, Martin Schauflinger, Clarissa Read, Thomas Böck, Manuel Hirner, Frederik Wienen, Stephen C. Graham, Jens von Einem

PoRVA G9P[23] and G5P[7] infections differentially promote PEDV replication by reprogramming glutamine metabolism

Haixin Liu, Haolun Tian, Pengcheng Hao, Huimin Du, Kun Wang, Yudong Qiu, Xiangrui Yin, Nana Wu, Qian Du, Dewen Tong, Yong Huang

Histone demethylase JMJD2D protects against enteric bacterial infection via up-regulating colonic IL-17F to induce β-defensin expression

Yong Zhang, Bei Li, Yilin Hong, Ping Luo, Zaifa Hong, Xiaochun Xia, Pingli Mo, Chundong Yu, Wenbo Chen

Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection

Aleksandra K. Drelich, Kempaiah Rayavara, Jason Hsu, Panatda Saenkham-Huntsinger, Barbara M. Judy, Vivian Tat, Thomas G. Ksiazek, Bi-Hung Peng, Chien-Te K. Tseng

Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Ebola, Sudan, Marburg and Lassa viruse

Amy Flaxman, Sarah Sebastian, Sofia Appelberg, Kuan M. Cha, Marta Ulaszewska, Jyothi Purushotham, Ciaran Gilbride, Hannah Sharpe, Alexandra J. Spencer, Sagida Bibi, Daniel Wright, Isabel Schmidt, Stuart Dowall, Linda Easterbrook, Stephen Findlay-Wilson, Sarah Gilbert, Ali Mirazimi, Teresa Lambe

Characterising plasmacytoid and myeloid AXL+ SIGLEC-6+ dendritic cell functions and their interactions with HIV

Freja A. Warner van Dijk, Orion Tong, Thomas R. O’Neil, Kirstie M. Bertram, Kevin Hu, Heeva Baharlou, Erica E. Vine, Kate Jenns, Martijn P. Gosselink, James W. Toh, Tim Papadopoulos, Laith Barnouti, Gregory J. Jenkins, Gavin Sandercoe, Muzlifah Haniffa, Kerrie J. Sandgren, Andrew N. Harman, Anthony L. Cunningham, Najla Nasr

Generation of a bloodstream form Trypanosoma brucei double glycosyltransferase null mutant competent in receptor-mediated endocytosis of transferrin

Samuel M. Duncan, Carla Gilabert Carbajo, Rupa Nagar, Qi Zhong, Conor Breen, Michael A. J. Ferguson, Calvin Tiengwe

The lipopeptide Pam3CSK4 inhibits Rift Valley fever virus infection and protects from encephalitis

Trevor Griesman, Cynthia M. McMillen, Seble Getenet Negatu, Jesse J. Hulahan, Kanupriya Whig, Lenka Dohnalová, Mark Dittmar, Christoph A. Thaiss, Kellie A. Jurado, David C. Schultz, Amy L. Hartman, Sara Cherry

Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites

Konstantinos Koussis, Silvia Haase, Chrislaine Withers-Martinez, Helen R. Flynn, Simone Kunzelmann, Evangelos Christodoulou, Fairouz Ibrahim, Mark Skehel, David A. Baker, Michael J. Blackman

The NS2B-PP1α-eIF2α axis: Inhibiting stress granule formation and Boosting Zika virus replication

Xiaoyan Wu, Linliang Zhang, Cong Liu, Qi Cheng, Wen Zhao, Pu Chen, Yali Qin, Mingzhou Chen

Short Reports

Pseudo-pac site sequences used by phage P22 in generalized transduction of Salmonella

Jessie L. Maier, Craig Gin, Benjamin Callahan, Emma K. Sheriff, Breck A. Duerkop, Manuel Kleiner