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June 2026

This immunofluorescence micrograph catches a cultured neuron 30 minutes after exposure to pathogenic prions (PrP Sc ). Protein Kinase C (PKC) primed by phosphorylation at serine-660 rapidly accumulates in specialized endosomes within the cell body, prior to its redistribution to dendritic spines. Colocalization of the primed PKC (red) with total PKC (green) produces striking yellow/orange fluorescence in the cell body. A similar effect is elicited by other strong PKC activators like phorbol ester. This acute spatial rearrangement of a key signaling kinase highlights a crucial, pre-degenerative window prior to neuronal fragmentation and death. Le et al. 2026

Image Credit: Nhat T. T. Le

Pearls

The natural history and evolution of dermatophytosis: Host immunity in acute and chronic infection

Aditya K. Gupta, Tong Wang, Anuradha Chowdhary, Ditte Marie L. Saunte, Roderick J. Hay, Vincent Piguet

Hippo signalling as a nexus in host–virus interactions

Aida Bahrami, Cheryl Walter, Amin Ardestani

Beyond resistance: Emerging methods to dissect drug responses in Leishmania

Beatriz Cristina Dias de Oliveira, Jorge Arias del Angel, Nicole Herrmann May, Michael P. Barrett, Malgorzata Anna Domagalska, Tom Beneke

Research Articles

Yad fimbriae are triggered by host cues and enhance extraintestinal pathogenic Escherichia coli tissue colonisation during bloodstream infection

Chloe Ellison, Curtis Cottam, Zheng Jie Lian, Tugce Onur, Burhan A. Choudhry, Yvette Yu Ting Ong, Minh-Duy Phan, Mark A. Schembri, James P. R. Connolly

Targeting BRD2 and BRD4 inhibit the growth of KSHV-infected immortalized endothelial cells through suppression of LANA translation

Jungang Chen, Jiaojiao Fan, Margaret Qin, Zhen Lin, Shengyu Mu, Lu Dai, Zhiqiang Qin

M-Sec promotes the production of infectious HIV-1 virus through the exocyst complex in macrophages

Reem M. Mahmoud, Masateru Hiyoshi, Randa A. Abdelnaser, Kazuaki Monde, Nami Monde, Takaaki Koma, Hidenobu Mizuno, Sara A. Habash, Naofumi Takahashi, Yosuke Maeda, Akira Ono, Shinya Suzu

ATAD3 megadalton complex in Plasmodium falciparum is essential for mitochondrial and cellular viability

Ijeoma C. Okoye, Ian M. Lamb, Yee-Wai Cheung, Joanne M. Morrisey, Manish Sharma, Rajat Kumar, Swati Dass, Anurag Shukla, River S. Rell, Michael W. Mather, Manuel Llinás, Yi-Wei Chang, Akhil B. Vaidya

Fingolimod increases cellular resistance to HIV-1 infection and limits viral reservoir size in peripheral CD4+ T-cells

Elisa Moraga, Núria Climent, Alejandro Sánchez-Molina, Sònia Vicens-Artés, María José Maleno, Gabriel Valero López, Carlos Galera Peñaranda, Juan Ambrosioni, José M. Miró, Josep Mallolas, Helena Albendín-Iglesias, José Alcamí, Sonsoles Sánchez-Palomino

Structural basis for conserved and distinct antigen recognition by a lineage of malaria-protective antibodies

Monika Jain, Fabien Cannac, Sashank Agrawal, Wen-Hsin Lee, Johannes R. Loeffler, Monica L. Fernández-Quintero, Gonzalo E. González-Páez, Re’em Moskovitz, Andrew B. Ward, Ian A. Wilson

Distinct prion conformers from brain and peripheral tissues of gene-targeted mice produce convergent CWD strain properties

Joseph P. DeFranco, Zoe N. Atkinson, Jenna Crowell, Xutong Shi, Sehun Kim, Julianna L. Sun, Sarah J. Kane, Glenn C. Telling

Culture-specific transcriptional drifts limit the fidelity of organoid infection models

Paula E. Schweizer, Wisal A. Elmagzoub, Sanaa M. Idris, Kamal H. Eltom, Julius B. Okuni, Lonzy Ojok, ElSagad Eltayeb, Ahmad Amanzada, Marianne Quaas, Gabriela Aust, Maxi Harzer, Thomas W. Vahlenkamp, Nico Jehmlich, Marlon R. Schneider, Guntram A. Grassl, Jens Puschhof, Knut Krohn, Ralph Goethe, Uwe Truyen, Jörg Galle, Ahmed Abd El Wahed

Feedback coordination of FoxO-mediated antibacterial immunity by PDGF/VEGF signaling establishes hemolymph microbiota homeostasis in shrimp

Ping-Ping Liu, Meng Zhang, Zhe Wei, Wei-Guang Wang, Jin-Xing Wang, Yuanning Li, Xian-Wei Wang

Evaluating beta-tubulin variants as predictors of benzimidazole resistance across Caenorhabditis nematodes

Amanda O. Shaver, Ryan McKeown, Joyce M. Reyes Otero, J.B. Collins, Daniel W. Hogan, James S. Fraser, Stephen M. Dreyer, Erik J. Ragsdale, Erik C. Andersen

HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition

August Myers, Monika Chandravanshi, Leanne S. Whitmore, Brendan F. Kohrn, Amina Negash, Dung N. Nguyen, Pooja Ralli-Jain, Kendra Cruickshank, Amit A. Upadhyay, Tysheena Charles, Christopher T. Edwards, Eric Hunter, Rama R. Amara, Marek K. Korzeniowski, Ling Niu, Edwin Pozharski, William D. Tolbert, Steven E. Bosinger, Scott R. Kennedy, Marzena Pazgier, Cynthia A. Derdeyn

Inhibition of high risk HPV31 E8^E2 repressor activity enables differentiation-independent genome amplification and E4 expression

Tina Melanie Rehm, Elke Straub, John Doorbar, Adam Grundhoff, Thomas Günther, Patrick Blümke, Thomas Iftner, Frank Stubenrauch

The Legionella pneumophila type IVb secretion system effector BinA subverts amino acid transport to sensitize TORC1 signaling in macrophages

Magdalena Circu, Reneau Castore, Brian Latimer, Stephanie Shames, Craig R. Roy, Ana-Maria Dragoi, Stanimir S. Ivanov

Low frequency variants can predetermine antiviral drug resistance development in herpes simplex virus type 1

Lena Jaki, Florian Full, Udo Gieraths, Valeria Falcone, Zsolt Ruzsics, Hartmut Hengel, Marcus Panning, Jonas Fuchs

Downregulation of miR-10b-3p by EBV promotes tumor growth and metastasis via ITGAV in nasopharyngeal carcinoma

Yu Zhang, Yaoqiang Shi, Yingdong Zou, Li Li, Ziqin Dian, Yuling Chen, Hang Zhao, Jiajun Wang, Yi Sun

Understanding the impact of Klebsiella pneumoniae K-Antigen based MAPS vaccine design on the immune response in animal models

Elena Palmieri, Gianina Florentina Belciug, Francesca Nonne, Luisa Massai, Silvia Valensin, Antonella De Rosa, Francesco Berlanda Scorza, Simona Rondini, Martina Carducci, Omar Rossi, Francesca Micoli, Carlo Giannelli

A chemical bactericide dioctyldiethylenetriamine (Xinjunan) exerts a non-lethal effect by inhibiting RpfG activity to regulate the quorum sensing system

Ling Jin, Xing Chen, Chaoyue Pang, Yongquan Huang, Changshun Ji, Yuanyuan Zhang, Xueqiao Liu, Yang Sun, Yu Chen

Exposure to herbivore-induced plant volatiles primes JA-dependent gossypol defenses in cotton

Chuanyu Zhu, Chengcheng Yao, Runxiao Liu, Tao Sun, Changsong Zou, Qingsong Liu, Sergio Rasmann, Ted C. J. Turlings, Yunhe Li

The assembly of stress granules during foot-and-mouth disease virus infection is uncoupled from activation of cellular intrinsic antiviral signalling

Mariana Marques, Yui Xi Wong, Zhaozhi Sun, Amina Yasmin, J. Paul Taylor, Alessia Ruggieri, Tobias J. Tuthill, Nicolas Locker

Central Nervous System T-cell immune architecture, and not HIV burden, tracks with cognition under long-term viral suppression

Mattia Trunfio, Gemma Caballero, Vanessa Gomez-Moreno, Simon A. Mallal, Celestine N. Wanjalla, Angela Jones, Karen Beeri, Alan Wells, Sarah LaMere, Ben Gouaux, Donald R. Franklin, Michael Corley, Ronald J. Ellis, David J. Moore, Scott L. Letendre, Davey Smith, Antoine Chaillon, Sara Gianella

Extended poly(A) tails are a shared feature of herpesvirus mRNAs

Erik Fuhrmann, Sae Toda, Jonas Leins, Pierina Cetraro, Vedang Deshpande, Jasmine Rowell, Edward A. Chapman, Carina Jacobsen, Kai A. Kropp, Mart M. Lamers, Elene Loliashvili, Mostafa Saleban, Ruth Verstraten, Carolin Vogt, Wiyada Wongwiwat, Werner J. D. Ouwendijk, Abel Viejo-Borbolla, Robert E. White, Angus C. Wilson, Hannah M. Burgess, Daniel P. Depledge

An ER-IMC bridge protein TgVPS13A and an IMC-resident scramblase TgDAT1 drive daughter budding in Toxoplasma gondii

Lin Zhao, Jiawen Fu, Swaroop Peddiraju, Heming Chen, Keqin Huang, Ying Zhang, Nishith Gupta, Qian Jiang, Honglin Jia

Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs

Nhat T. T. Le, Robert C. C. Mercer, Cheng Fang, Aravind Sundaravadivelu, Adam T. Labadorf, Weiwei Lin, Julian Kwan, Benjamin Blum, Andrew Emili, David A. Harris

Maturation of HIV-1 neutralizing antibodies in a germinal center conditional expression mouse model

Ming Tian, Jillian Davis, Hwei-Ling Cheng, Lily M. Thompson, Marie-Elen Tuchel, Aimee Chapdelaine Williams, Audrey Yin, Bailey Wilder, Ivy DiBiase, Michael S. Seaman, Frederick W. Alt

Hidden hematological, biochemical and immune costs of asymptomatic malaria infections in semi-wild chimpanzees

Anais Nowakowski, Eric Elguero, Katie Patterson, Anne Boissière, Fanny Degrugillier, Christine Sidobre, Celine Arnathau, Pauline Grentzinger, Eric Willaume, Arthur M. Talman, Benoit Malleret, Larson Boundenga, Barthelemy Ngoubangoye, Franck Prugnolle, Samuel C. Wassmer, Virginie Rougeron

Merkel cell polyomavirus exploits extracellular vesicles for skin infection and host immune evasion through activated Wnt signaling

Alexander M. Pham, Luz E. Ortiz, Han Chen, Neil Christensen, Hyun Jin Kwun

Selective sugar transport supports Proteus mirabilis fitness in the urinary tract

Allyson E. Shea, Shiuhyang Kuo, Surbhi Gupta, Sara N. Smith, Trishna Appaji, Taylor Mitchell, Harry L. T. Mobley, Melanie M. Pearson

Latent cytomegalovirus disrupts innate NK cell responses to P. falciparum and impairs parasite control in first infection in adults

Reena Mukhiya, Jessica R. Loughland, Nicholas L. Dooley, Zuleima Pava, Damian A. Oyong, Dean W. Andrew, Julianne Hamelink, Kiana Berry, James S. McCarthy, Bridget E. Barber, J. Alejandro Lopez, Christian R. Engwerda, Michelle J. Boyle

Schistosoma japonicum histone acetyltransferase 1 (SjHAT1): A novel anti-schistosomal drug target

Jing Xu, Yu-Xin Wang, Ping Huang, Ya-Nan Zhang, Huan Sun, Ting-Zheng Zhan, Chao-Ming Xia

Predictive value of PfEMP1 antibody profiles for the course of controlled human malaria infections

Yannick D. Höppner, Ralf Krumkamp, Hikaru Nagaoka, Charlotte Wapler, Hannah Honner, Louise Turner, Jean Claude Dejon-Agobé, Yabo J. Honkpehedji, Jeannot Fréjus Zinsou, Jana Held, Meral Esen, Heidrun von Thien, Iris Bruchhaus, B. Kim Lee Sim, Stephen L. Hoffman, Peter G. Kremsner, Tim-Wolf Gilberger, Bertrand Lell, Takafumi Tsuboi, Thomas Lavstsen, Eizo Takashima, Benjamin Mordmüller, Anna Bachmann

SUMOylation and ubiquitination reciprocally regulate SMCHD1 antiviral activity against herpes simplex virus 1

Xuezhang Tian, Xinyue Wang, Shaowei Wang, Yunhong Zhong, Yanlin Xia, Yang Chen, Ling He, Dongli Pan, Ke Lan, Junjie Zhang

O-GlcNAcylation licenses RNF166 to degrade the M protein of porcine coronaviruses

Runhui Qiu, Yucheng Zhang, Junwei Zhou, Jianan Wang, Wenbing Tang, Xinliang Xie, Yan Cheng, Tong Ding, Peng Sun, Yuting Shi, Caili Xi, Yanrong Zhou, Liurong Fang, Shaobo Xiao

HSV-2 gC2 mRNA immunization in mice protects by producing antibodies that bind immune evasion epitopes

Lauren M. Hook, Tina M. Cairns, Sita Awasthi, Kevin P. Egan, Manaswini Gopalakrishnan, Zauraiz Syeda, Norbert Pardi, Tomas Bergstrom, Gary H. Cohen, Harvey M. Friedman

The human parasite, Toxoplasma gondii, is paralyzed without two components of the apical polar ring

Jonathan Munera Lopez, Luisa F. Arias Padilla, Isadonna F. Tengganu, Yan Hao, Ying Zhang, Laurence Florens, John M. Murray, Ke Hu

Endogenous viral elements trace the ancient origins and early evolution of the Caulimoviridae

Héléna Vassilieff, Saad Serfraz, Nathalie Choisne, Andrew D. W. Geering, Pierre Lefeuvre, Pierre-Yves Teycheney, Florian Maumus

Dissecting the host determinants of orthoflavivirus infection using QIC-seq

Allison J. Dupzyk, Benjamin S. Waldman, James Zengel, Fabio Zanini, Jan E. Carette

Cyclic AMP compartmentalization drives signal specificity to control vector colonization and mammalian host infection by American trypanosomes

Milad Ahmed, Joshua Carlson, Asima Das, Syeda Farjana Hoque, Joshua B. Benoit, Miguel A. Chiurillo, Noelia Lander

A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss

Sriparna Mukherjee, Vladimir Grouza, Alex Tchung, Amandine Even, Moein Yaqubi, Marius Tuznik, Tyler Cannon, Sherilyn Junelle Recinto, Christina Gavino, Marie-Josée Bourque, Nicolas Giguère, Heidi McBride, Michel Desjardins, Samantha Gruenheid, Jo Anne Stratton, David A. Rudko, Louis-Eric Trudeau

Corrections

Correction: Molecular response to the non-lytic peptide bac7 (1–35) triggers disruption of Klebsiella pneumoniae biofilm

Robert L. Beckman I. V, Berta Victoria, Flor Z. Santiago, Gabriela N. Echeverria, Bruno V. Pinheiro, Marcelo D.T. Torres, Logan Suits, Shantal Garcia, Paeton L. Wantuch, Cesar de la Fuente-Nunez, Prahathees Eswara, David A. Rosen, Renee M. Fleeman

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Correction: Insights into the structural changes that trigger receptor binding upon proteolytic activation of Bacillus thuringiensis Vip3Aa insecticidal protein

Oscar Infante, Isabel Gómez, Angel E. Pélaez-Aguilar, Luis A. Verduzco-Rosas, Rosalina García-Suárez, Blanca I. García-Gómez, Zeyu Wang, Jie Zhang, Adan Guerrero, Alejandra Bravo, Mario Soberón

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Correction: Structural basis for substrate recognition and inhibition of thioredoxin glutathione reductase from Schistosoma japonicum: Implications for antiparasitic development

Songqing Wang, Wenbin Hong, Shukun Zhong, Zhijian Liang, Tianyichen Xiao, Chuchu Zhang, Xianshu Liu, Ziyi Dai, Yunlong Li, Siqi Wu, Qixu Cai, Caiming Wu, Yuxuan Huang, Peicheng Hong, Haixia Ren, Shaowei Li, Tianwei Lin, Xueqin Chen, Shuaiqin Huang

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