Virulence determinants of Fusarium oxysporum for clinical infections

Jeffrey J. Coleman, Neta Shlezinger, Li-Jun Ma

PLOS Pathogens: published October 1, 2026 | https://doi.org/10.1371/journal.ppat.1014630

Born to resist: Understanding natural resistance to Haemonchus contortus in sheep

Hannah Teddleton, Elizabeth Shepherd

PLOS Pathogens: published October 5, 2026 | https://doi.org/10.1371/journal.ppat.1014658

Why does rotavirus vaccine effectiveness vary around the globe?

Sarah Woodyear, Nabila Nawar Binti, Sarah L. Caddy

PLOS Pathogens: published October 9, 2026 | https://doi.org/10.1371/journal.ppat.1014670

Mysterious girls: The biology of female Cryptosporidium parasites

Sarah Stevens, Peyton Goddard, Katelyn A. Walzer, Mattie Christine Pawlowic

PLOS Pathogens: published October 12, 2026 | https://doi.org/10.1371/journal.ppat.1014678

From CBASS and Thoeris to Panoptes: Phage sponges and the inversion of bacterial immunity

Ruoqi Zheng, Leiliang Zhang

PLOS Pathogens: published October 27, 2026 | https://doi.org/10.1371/journal.ppat.1014717

MUCOR-ADVANCE: Uniting multidisciplinary science to defeat a deadly fungus

Sebastian Wurster, Adam G. Stewart, Yiyou Gu, Eman G. Youssef, Teny M. John, Priya Uppuluri, Georgios Chamilos, Scott Filler, Vincent Bruno, Ashraf S. Ibrahim, Dimitrios P. Kontoyiannis, on behalf of the MUCOR-ADVANCE consortium

PLOS Pathogens: published October 28, 2026 | https://doi.org/10.1371/journal.ppat.1014736

Guardians of the blood: How Kupffer cells control systemic infection

Lindsey Orthner, Josefien W. Hommes, Bas G. J. Surewaard

PLOS Pathogens: published October 30, 2026 | https://doi.org/10.1371/journal.ppat.1014744

Rebuilding the gut: Decoding enteric pathogenesis using next-generation human in vitro models

Linus H. Schweizer, Ashley Gilliland, Yan Chen, Artemis Melville-Bowser, Bruce A. Vallance

PLOS Pathogens: published October 26, 2026 | https://doi.org/10.1371/journal.ppat.1014718

The mitochondrial ubiquitin ligase MARCHF5 cooperates with MCL1 to inhibit apoptosis in KSHV-transformed primary effusion lymphoma cell lines

Prasanth Viswanathan, Justine R. Bersonda, Jackson Gill, Alyssandra Navarro, Allison C. Farrar, Thomas Caldarera, Andrew Murphy, Daniel Dunham, Karl W. Boehme, Mark Manzano

PLOS Pathogens: published October 1, 2026 | https://doi.org/10.1371/journal.ppat.1014665

Salmonella infection and biofilms drive anti-C1q and anti-dsDNA autoantibodies in systemic autoimmunity

Kaitlyn Grando, Molly Elkins, Lauren Nicastro, Shingo Bessho, Sophia Olubajo, Anita Kowal, Vincent Tam, Roberto Caricchio, David Pisetsky, Gregg J. Silverman, Çagla Tükel

PLOS Pathogens: published October 1, 2026 | https://doi.org/10.1371/journal.ppat.1014666

Misleading inference of schistosome epidemiology from ribosomal internal transcribed spacer (ITS) and mitochondrial DNA

Egie E. Enabulele, Roy N. Platt II, Ehizogie E. Adeyemi, Martins S. O. Aisien, Oluwaremilekun G. Ajakaye, Mahmud U. Ali, Ebube C. Amaechi, Tolulope E. Atalabi, Timothy Auta, Oluwaseun B. Awosolu, Adamu G. Dagona, Omoyemwen Edo-Taiwo, Chika P. Ejikeugwu, Christopher Igbeneghu, Victor S. Njom, Marian Onwude-Agbugui, Mary-Kate N. Orji, Funso O. P. Oyinloye, Esther Oyemade, Habibat J. Ozemoka, Christopher R. Pam, Uchenna I. Ugah, Jenna M. Hulke, Grace A. Arya, Timothy J. C. Anderson

PLOS Pathogens: published October 1, 2026 | https://doi.org/10.1371/journal.ppat.1014625

Quantitative and qualitative differences in anti-Envelope IgG-secreting cells distinguish subclinical and hospitalized dengue in a Cambodian pediatric cohort

Amandine Trouchet, Sokchea Lay, Matteo Broketa, Pablo Canales-Herrerias, Angga Perima, Bruno Iannascoli, Sotheary Sann, Borita Heng, Sowath Ly, Veasna Duong, Gaël A. Millot, Laura Walker, Patrick England, Giovanna Barba-Spaeth, Tineke Cantaert, Pierre Bruhns

PLOS Pathogens: published October 1, 2026 | https://doi.org/10.1371/journal.ppat.1014552

Structural basis of diverse substrate recruitment by the HIV-1 Vpr-hijacked CRL4(VprBP) E3 ligase

Dianhong Wang, Weijia Ding, Jingwei Xu, Ruofan Li, Tamino Cairoli, Qi Liu, Yiying Zhu, Ye Xiang

PLOS Pathogens: published October 1, 2026 | https://doi.org/10.1371/journal.ppat.1014610

Differentiated mosquito adaptive strategies underlie regional dominance of three ECSA sub-lineages in chikungunya virus

Yuhua Liao, Jingqi Yang, Jingzhe Shang, Hangyu Zhou, Aiping Wu

PLOS Pathogens: published October 5, 2026 | https://doi.org/10.1371/journal.ppat.1014677

Active transcriptome remodeling underlies antimony-induced drug tolerance in persister-like Leishmania parasites

Eyson Quiceno, Cristian Camilo Rodríguez-Almonacid, Khalid Omeir, Jacob Ancira, Caleb Phillips, Zemfira N. Karamysheva

PLOS Pathogens: published October 5, 2026 | https://doi.org/10.1371/journal.ppat.1014682

SUMOylation of pseudorabies virus thymidine kinase regulates its nuclear localization and facilitates neuronal replication and reactivation

Xuan Chen, Chuang Li, Dongyue Xing, Jingjing Song, Yun Liu, Yuxin Liu, Qin Huang, Yu Kuang, Xian Li, Jinlei Zhang, Yuqi Zhang, Nianzhi Zhang, Rulan Bai, Changyong Cheng, Jin Yuan, Jun Tang, Rui Zhang

PLOS Pathogens: published October 5, 2026 | https://doi.org/10.1371/journal.ppat.1014653

The serine-rich C-terminal tail of the Listeria monocytogenes secretion chaperone PrsA2 is critical for bacterial virulence and resistance to cell-wall active antibiotics

Allison H. Kumar, Charles Agbavor, Francis Alonzo 3rd, Laty A. Cahoon

PLOS Pathogens: published October 5, 2026 | https://doi.org/10.1371/journal.ppat.1014676

Acetylation enables a dual-targeting fungal effector to inhibit insect immunity and development

Yulong Wang, Ying Dong, Yang Zhang, Siying Wu, Deshui Yu, Guang Yang, Shuqian Gao, Yang Yang, Shihao Dong, Li Qin, Bo Huang

PLOS Pathogens: published October 5, 2026 | https://doi.org/10.1371/journal.ppat.1014680

The RpfF Acyl-ACP thioesterase of major rice pathogen Xanthomonas oryzae pv. oryzae is essential for maintenance of membrane function and virulence

Lizhen Luo, Zhe Hu, Mingfeng Yan, John E. Cronan, Haihong Wang

PLOS Pathogens: published October 6, 2026 | https://doi.org/10.1371/journal.ppat.1014669

Sex differences in hepatitis A virus infection in mice

Ichiro Misumi, Itoe Shiota, Tomoyuki Shiota, Jingyu Zhao, John M. Cullen, Stanley M. Lemon, Jason K. Whitmire

PLOS Pathogens: published October 6, 2026 | https://doi.org/10.1371/journal.ppat.1014660

GlRac regulates an ATG8-independent autophagy-like pathway in Giardia lamblia

Angélica Hollunder Klippel, Corryn Newman-Boulle, Grant Reed, Dule Dule, Saanya Kedia, Martin T. Kelty, Wai Pang Chan, Han-Wei Shih, Alexander R. Paredez

PLOS Pathogens: published October 6, 2026 | https://doi.org/10.1371/journal.ppat.1014624

Targeting the Cav1.2-KCa1.1 axis prevents rabies virus internalization and protects against lethal infection

Ziruo Sun, Jinqiu Wang, Zhiyuan Wen, Lei Shuai, Wenjing Sun, Mengjie Yang, Jinyu Wang, Junyu Chen, Tengteng Mi, Xianjing Zhou, Peiran Zhou, Nannan Lv, Zhenbo Zhao, Jinying Ge, Weiye Chen, Xijun Wang, Chong Wang, Zhigao Bu, Jinliang Wang

PLOS Pathogens: published October 6, 2026 | https://doi.org/10.1371/journal.ppat.1014675

Cryo-EM reveals the quaternary architecture of TenpIN type III toxin-antitoxin RNP complex common to pathogenic bacteria

Kavyashree Nadig, Surekha Padmanaban, Salik Noor, Sankaran Sandhya, Parthasarathy Manikandan, Somnath Dutta, Mahavir Singh

PLOS Pathogens: published October 6, 2026 | https://doi.org/10.1371/journal.ppat.1014690

Integrated in vivo and transcriptomic analyses of lethal Oropouche virus infection reveal suppression of pathogenic host responses by antiviral therapy

Cássia Sousa Moraes, Gabriel Gonzalez, Akihiko Sato, Shigeru Miki, Atsuko Inoue, Koshiro Tabata, Joshua W. Kranrod, Chilekwa Frances Kabamba, Aiko Ohnuma, Keita Matsuno, Rio Harada, Shinji Saito, Naoki Akimoto, Michihito Sasaki, Yasuko Orba, William W. Hall, Hirofumi Sawa, Yukari Itakura

PLOS Pathogens: published October 7, 2026 | https://doi.org/10.1371/journal.ppat.1014647

KSHV K15 genetic heterogeneity is associated with Kaposi sarcoma aggressiveness through modulation of the host inflammatory microenvironment

Yu Zhang, Peng Wang, Jingzhan Zhang, Yunying Wang, Tingting Li, Yuan Ding, Xiaojing Kang

PLOS Pathogens: published October 7, 2026 | https://doi.org/10.1371/journal.ppat.1014615

Glutamine from plasma-like medium fuels nitrogen metabolism and influences proliferation in Leptospira interrogans

Matthew H. Ward, Nathan Scherer, Leah P. Shriver, Gary J. Patti

PLOS Pathogens: published October 8, 2026 | https://doi.org/10.1371/journal.ppat.1014534

Receptor-induced activation of MERS-CoV spike revealed by time-course cryo-EM

Yajie Wang, Xiyuan Pan, Yuxuan Jiang, Zhimin Liu, Yinong Qiu, Zhenguo Chen, Lei Sun

PLOS Pathogens: published October 8, 2026 | https://doi.org/10.1371/journal.ppat.1014545

A pore-forming toxin monalysin contributes to infection-induced suppression of defecation in female Drosophila

Marko Rubinić, Yi Yu, Kathirvel Alagesan, Dagmar Frahm, Igor Iatsenko

PLOS Pathogens: published October 8, 2026 | https://doi.org/10.1371/journal.ppat.1014696

Assembly-active and -inactive forms of HBV capsid protein provide distinctly different binding sites for capsid assembly modulators

Liam W. Scott, Carolina Pérez-Segura, Jodi A. Hadden-Perilla, Adam Zlotnick

PLOS Pathogens: published October 9, 2026 | https://doi.org/10.1371/journal.ppat.1014700

Novel EG95-based mRNA vaccines induce long-term protective immunity against echinococcosis

Wei-Gang Chen, Li Li, Guo-Dong Dai, Yao-Dong Wu, Chuan-Gang Zhu, Huan Zhang, Xiu-Rong Li, Le Li, Nian-Zhang Zhang, Li-Qun Wang, Guo-Cai Li, Wen-Ling Ma, Ji-Tao Pan, Ming-Lu Tan, Fu-Lan Da, Hong Yin, Bao-Quan Fu, Xue-Nong Luo, Hong-Bin Yan, Wan-Zhong Jia

PLOS Pathogens: published October 9, 2026 | https://doi.org/10.1371/journal.ppat.1014659

Trypanosoma brucei infection remodels the uterine immune environment and drives neuroendocrine dysfunction

Olivia M. Shorthouse, Chloe Barnes, Stefano A. P. Colombo, Jessica Costa, Katrine Wonsbek, Anmoyul Mohon, Andrew S. MacDonald, Elizabeth Mann, Alice H. Costain, Juan F. Quintana

PLOS Pathogens: published October 9, 2026 | https://doi.org/10.1371/journal.ppat.1014667

Exercise promotes host anti-infection activity through CNDP2 metabolite-mediated inflammasome hyperactivation

Yan Qian, Xiangyun Cheng, Qiannv Liu, Chunlei Wang, Chun Kong, Mengqian Li, Xiangyang Geng, Liya Ai, Mindi Zhao, Shuo Wang, Dong Jiang, Pengyan Xia

PLOS Pathogens: published October 9, 2026 | https://doi.org/10.1371/journal.ppat.1014554

Large-scale genome re-annotation uncovers pathogen-specific lncRNA regulators of fungal growth and virulence

Renwei Gao, Zhenxiu Liu, Han Tang, Ning Wang, Xinying Xue, Ling Lu, Yuanwei Zhang

PLOS Pathogens: published October 9, 2026 | https://doi.org/10.1371/journal.ppat.1014681

Astroviruses use mucus secretion as a novel form of viral egress

Natalie Pedicino, Melanie G. Kirkpatrick, Michelle Ann Pablo, Jacob Gulman, Nicole Heredia-Osuna, Valerie Cortez

PLOS Pathogens: published October 9, 2026 | https://doi.org/10.1371/journal.ppat.1014683

Zika virus produces two isoforms of the NS2A protein that play mutually exclusive roles in viral replication and virion assembly

Breanna N. Landry, Olivia J. Klann, Hannah C.H. Hauch, Cheyanne L. Bemis, Jonathan E. Owen, Jayden Harris, Trisha R. Barnard, Christopher J. Neufeldt, Selena M. Sagan

PLOS Pathogens: published October 12, 2026 | https://doi.org/10.1371/journal.ppat.1014609

Structural and biochemical insights into HCV envelope proteins for germline-targeting vaccines

ItaiG. Yechezkel, Hila E. Maimon, Ariel Tennenhouse, Fang Chen, Haneen Tarabih, Jenna Weisz, Rina Fraenkel, Sarel J. Fleishman, Mansun Law, Netanel Tzarum

PLOS Pathogens: published October 12, 2026 | https://doi.org/10.1371/journal.ppat.1014651

Vaccination accelerates the race of influenza virus against collective immunity

Igor M. Rouzine

PLOS Pathogens: published October 12, 2026 | https://doi.org/10.1371/journal.ppat.1014311

Human cytomegalovirus antagonizes SMC5/6 driven genome silencing via UL35 instituted proteasomal degradation of SLF2

Francesco Montagner, Myriam Scherer, Cora Stegmann, Friedrich Hahn, Claudia Ploil, Christina Sandra Einsiedler, Elena Katharina Brosch, Takahiro Maeki, Ramya Ramani, Nicole Andrée-Busch, Melanie M. Brinkmann, Thomas Stamminger

PLOS Pathogens: published October 12, 2026 | https://doi.org/10.1371/journal.ppat.1014709

Transcriptional programs controlling sporulation in Phytophthora respond to nutrition, humidity, and cryptochrome-mediated light signals

Andrea L. Vu, Timothy A. Harris, Howard S. Judelson

PLOS Pathogens: published October 12, 2026 | https://doi.org/10.1371/journal.ppat.1014705

GTPase GBP7 promotes HSV-1 infection by interacting with and activating eEF1A1 to accelerate the protein translation process

Jinshen Wang, Liangbing Man, Binhao Rong, Kunyu Lu, Luping Cheng, Jianfu He, Haowei Li, Hao Su, Xinxin Lin, Ru Li, Min Zou, Chan Yang, Shuwen Liu

PLOS Pathogens: published October 12, 2026 | https://doi.org/10.1371/journal.ppat.1014652

Toxin-mediated tRNA^Trp depletion drives Trp-codon-dependent reprogramming in Mycobacterium tuberculosis while selectively enriching the PDIM biosynthetic machinery

Safreen Sain, Unnati Chauhan, Valdir C. Barth Jr, Eduardo A. Troian, Bruno L. Abbadi, Basanti Malakar, Robert N. Husson, Nancy A. Woychik

PLOS Pathogens: published October 12, 2026 | https://doi.org/10.1371/journal.ppat.1014679

AcNR1F orchestrates epidermal remodeling to enable host adaptation in Angiostrongylus cantonensis

Jinwei Lv, Yanling Ma, Jiaying Lai, Song Li, Ke Ning, Kangping Lu, Lihua Xiao, Yaoyu Feng, Dongjuan Yuan

PLOS Pathogens: published October 12, 2026 | https://doi.org/10.1371/journal.ppat.1014691

MicroRNA-1246 regulates macrophage lipid metabolism and is involved in resistance to human Mycobacterium tuberculosis infection

Ashutosh Tripathi, Venkata Sanjeev Kumar Neela, Rajesh Kumar Radhakrishnan, Kamakshi Prudhula Devalraju, Anvesh Kumar Bogam, Tanmoy Mukherjee, Varalakshmi Mallidi, Abhinav Vankayalapati, Mohammed Soheb Sadath Ansari, Carlos Arana, Sindhu Joshi, Karan P. Singh, Vijaya Lakshmi Valluri, Ramakrishna Vankayalapati, Deepak Tripathi

PLOS Pathogens: published October 13, 2026 | https://doi.org/10.1371/journal.ppat.1014454

Intracellular SCARB2 mimicry overcomes decoy failure to broadly inhibit enteroviruses

Shijin Wang, Yubin Tang, Songyang Lai, Jiaxin Yang, Qingran Yang, Xize Liu, Xiao-Fang Yu, Haoran Guo, Wei Wei

PLOS Pathogens: published October 13, 2026 | https://doi.org/10.1371/journal.ppat.1014699

The N-terminus of alpha-1 giardin, a parasitic annexin orthologue, is essential for oligomerization and lipid-binding activity

Dawid Warmus, Corina D. Wirdnam, Erina A. Balmer, Tendai Muronzi, Manfred Heller, Özlem Tastan Bishop, Carmen Faso

PLOS Pathogens: published October 14, 2026 | https://doi.org/10.1371/journal.ppat.1014407

Intranasal HSV‑1 infection drives region‑specific interferon‑dominant microglial remodeling

Seth Frietze, Cameron Lunn, Dean Oldham, Joseph R. Boyd, Andrew N. Bubak, Amalia Bustillos Saucedo, Maria A. Nagel, Diego Restrepo, Kimberley D. Bruce, Christy S. Niemeyer

PLOS Pathogens: published October 14, 2026 | https://doi.org/10.1371/journal.ppat.1014684

Human cytomegalovirus exploits host chromatin remodeler MORC2 to promote the DNA damage response on viral genomes

Jiseok Jeong, Dongjoon Jeong, Sungwon Lee, Junhyun Park, Hyewon Kim, Kwangseog Ahn

PLOS Pathogens: published October 14, 2026 | https://doi.org/10.1371/journal.ppat.1014693

HIV-1 compartmentalization in the central nervous system during cryptococcal meningitis: Analysis of viral, fungal, and host factors

Maura Manion, Camille M. Lange, Ana M. Ortega-Villa, Christine M. Fennessey, Brandon F. Keele, Matthew Moeser, Helene Highbarger, Kristi Huik, Natalie Lindo, Christian Gonsalves, James Virga, David B. Meya, Sarah B. Joseph, David R. Boulware, Irini Sereti, Frank Maldarelli

PLOS Pathogens: published October 15, 2026 | https://doi.org/10.1371/journal.ppat.1014697

The pathogenicity factor of DNA virus interacts with Arabidopsis deubiquitinases UBP12/13 to promote viral infection

Shun Li, Fangqin Yu, Yi Zhang, Siqi Liu, Hui-Wen Wu, Nam-Hai Chua, Shulin Deng

PLOS Pathogens: published October 15, 2026 | https://doi.org/10.1371/journal.ppat.1014686

Structural basis of antigenic drift in FMDV O/Cathay topotype variants revealed by porcine-derived single B-cell neutralizing antibodies

Fengjuan Li, Shanquan Wu, Shulun Huang, Lv Lv, Yimei Cao, Huifang Bao, Pu Sun, Xingwen Bai, Jiaxin Yang, Jingjing Zha, Qiongqiong Zhao, Hehe Zhang, Dong Li, Jijun He, Zaixin Liu, Pinghua Li, Zengjun Lu, Dongsheng Lei, Kun Li

PLOS Pathogens: published October 15, 2026 | https://doi.org/10.1371/journal.ppat.1014650

Venom vesicles from the parasitoid Ganaspis hookeri facilitate venom protein entry into host immune cells

Nicholas M. Bretz, Chris Lark, Sarah Perkel, Rebecca Jackson, Jeremy D. Driskell, James A. Mobley, Nathan T. Mortimer

PLOS Pathogens: published October 16, 2026 | https://doi.org/10.1371/journal.ppat.1014707

Selective persistence of HIV-1-infected T cell clones can occur through immune reprogramming driven by defective, transcriptionally active proviruses

Martin V. Hamann, Lisa Brauckmann, Christoph Schwarz, Michael Spohn, Ramon Stoeck, Sabrina M. Leddy, Julie Frouard, Maisha Adiba, Riekje Winzer, Fabian Hausmann, Sanamjeet Virdi, Adam Grundhoff, Cedric Feschotte, Daniel Sauter, Frauke Muecksch, Nadia R. Roan, Eva Tolosa, Ulrike C. Lange

PLOS Pathogens: published October 20, 2026 | https://doi.org/10.1371/journal.ppat.1014618

PDIM drives the transition from repairable to catastrophic EsxA-mediated vacuole membrane damage during Mycobacterium marinum infection

Céline Michard, Angélique Perret, Mélanie Foulon, Hendrik Koliwer-Brandl, Hubert Hilbi, Thierry Soldati

PLOS Pathogens: published October 21, 2026 | https://doi.org/10.1371/journal.ppat.1014721

Diverse infection models demonstrate robust resistance of Mycobacterium tuberculosis to innate immunity

Marian R. Fairgrieve, Ella C. Brydon, Roberto A. Chavez, Dmitri I. Kotov, Russell E. Vance

PLOS Pathogens: published October 21, 2026 | https://doi.org/10.1371/journal.ppat.1014713

Lyssavirus matrix protein stabilizes RGS4 to suppress ferroptosis via incomplete autophagy and iron metabolic reprogramming

Jianqing Zhao, Pingping Chen, Meixin Sun, Chuan Liang, Zhen F. Fu, Ling Zhao, Ming Zhou

PLOS Pathogens: published October 21, 2026 | https://doi.org/10.1371/journal.ppat.1014726

Wolbachia outcompetes mosquito-borne viruses by reprogramming host ATPSβ1-driven ATP metabolism toward symbiotic proliferation

Hao Yuan, Yalan Zhang, Yaqi Zhao, Chaojun Wang, Yuanyuan Zhou, Qian Ni, Xiaodan Li, Bo Zhang, Yong Wang, Liang Cai, Hong Liu, Jinglin Wang, Juntao Gong, Meichun Zhang, Zhiyong Xi, Xiaoling Pan

PLOS Pathogens: published October 21, 2026 | https://doi.org/10.1371/journal.ppat.1014692

Adaptive metabolic reprogramming of the brain tissue during late-stage Trypanosoma brucei infection maintains host learning and memory

Nadin Fathallah, Chloe Barnes, Rebecca Chatwin, Jayde Whittingham-Dowd, John J. Worthington, Lucy Jackson-Jones, Neil Dawson, Michael D. Urbaniak

PLOS Pathogens: published October 22, 2026 | https://doi.org/10.1371/journal.ppat.1014734

Oral uracil treatment increases susceptibility to rectal SIV infection

Elizabeth G. Bodykevich, Fabiola Castello Casta, Jacob K. Flynn, Charlotte A. Nichols, Glenn A. Nardone, Christine M. Fennessey, Kelsie Brooks, Delmy Ruiz, Jennifer Simpson, Carol L. Vinton, Brandon F. Keele, Jason M. Brenchley, Alexandra M. Ortiz

PLOS Pathogens: published October 22, 2026 | https://doi.org/10.1371/journal.ppat.1014716

Multi-Dot/Icm effector mutants reveal distinct host responses in Legionella infected macrophages

Raissa Wibawa, Pengfei Li, Linden J. Gearing, Sacha Pidot, Yuliia Faidiuk, Wilson Wong, Garrett Z. Ng, Kathleen McCaffrey, Paul J. Hertzog, Shivani Pasricha, Elizabeth L. Hartland

PLOS Pathogens: published October 22, 2026 | https://doi.org/10.1371/journal.ppat.1014083

HIV-1 cell-to-cell infection of macrophages escapes restriction by the BST-2 host cell factor independently of the Vpu counteracting viral protein

Sen Yan, Agathe Durringer, Marie Woottum, Serge Benichou

PLOS Pathogens: published October 23, 2026 | https://doi.org/10.1371/journal.ppat.1014702

Dual activities of lysis and capsule degradation enable the bacteriophage protein Lys33795 to effectively disrupt Streptococcus suis biofilms

Yalu Ji, Meimei Zhang, Liran Song, Hui Ning, Li Wang, Cao Qiu, Jingmin Gu

PLOS Pathogens: published October 23, 2026 | https://doi.org/10.1371/journal.ppat.1014741

Rapid and convergent evolution of Wolbachia genomes in mosquito cell culture

Julien Martinez, Anne W. Wairimu, Steven P. Sinkins

PLOS Pathogens: published October 23, 2026 | https://doi.org/10.1371/journal.ppat.1014735

L-Histidine resensitizes multidrug-resistant bacteria to carbapenems by inhibiting New Delhi metallo-β-lactamase activity

Yanqing Yin, Sulan Hu, Dan Fang, Yanhu Huang, Miaomiao Huang, Suhong Liu, Zhiqiang Wang, Yuan Liu

PLOS Pathogens: published October 26, 2026 | https://doi.org/10.1371/journal.ppat.1014728

Newly developed monoclonal antibodies for marmoset immunosuppression enable KSHV lytic replication and salivary shedding: A promising model for KSHV pathogenesis studies

Li Han, Esther Rodriguez, Caitlin Shaw, Joe Kurian, Saverio Capuano, Gabriela M. Escalante, Murali Muniraju, Kyle Jung, Lorraine Z. Mutsvunguma, Kathleen Engelman, Jae Jung, Corinna N. Ross, Ivana G. Reidel, Javier Gordon Ogembo

PLOS Pathogens: published October 26, 2026 | https://doi.org/10.1371/journal.ppat.1014698

Hydrophobic remodeling of the SARS-CoV-2 RBD large loop attenuates ACE2 engagement and viral fitness

Aojie Wang, Huimin Guo, Haonan Yang, Haojin Chen, Anna Imojara, Bin Ju, Zheng Zhang, Renhong Yan

PLOS Pathogens: published October 26, 2026 | https://doi.org/10.1371/journal.ppat.1014742

Type I interferon signaling promotes early innate control of Borrelia burgdorferi infection

Raj Priya, Sajith Raghunandanan, Darko Mihaljica, Nada S. Alakhras, Mark H. Kaplan, X. Frank Yang

PLOS Pathogens: published October 26, 2026 | https://doi.org/10.1371/journal.ppat.1013996

Comparative S-acyl-proteomics reveals post-translational modulation of fungal purine metabolism for Verticillium wilt

Chi Li, Wenyang Zhang, Shuaifei Cui, Jian Zhang, Yuzhen Li, Xiaoshi Liu, Yang Li, Zhiying Wang, Wenjie Huang, Gongda Li, Chengwei Yang, Shijuan Yan, Jianbin Lai

PLOS Pathogens: published October 26, 2026 | https://doi.org/10.1371/journal.ppat.1014730

Vaccinia virus growth factor induces divergent signaling programs and biological outcomes from cellular epidermal growth factor

Anil Pant, Lara Dsouza, Zhilong Yang

PLOS Pathogens: published October 26, 2026 | https://doi.org/10.1371/journal.ppat.1014725

Removal of VirD2 from a synthetic T-DNA complex of Agrobacterium by the host DNA repair protein TDP2

Benoît Lacroix, Vitaly Citovsky

PLOS Pathogens: published October 26, 2026 | https://doi.org/10.1371/journal.ppat.1014750

Evidence for holocentric centromeres in the early branching apicomplexan parasite Cryptosporidium parvum

Abigail Kimball, Wanyi Huang, Melanie Key, Rui Xu, Lisa Funkhouser-Jones, L. David Sibley

PLOS Pathogens: published October 26, 2026 | https://doi.org/10.1371/journal.ppat.1014708

The Trichomonas vaginalis pseudocyst is a viable cell stage with a distinct transcriptome and an intact membrane

Mari Shiratori, Francisco Callejas-Hernández, Jordan C. Orosco, Steven A. Sullivan, Carlos Carmona Fontaine, Jane M. Carlton

PLOS Pathogens: published October 26, 2026 | https://doi.org/10.1371/journal.ppat.1014739

MARK3 promotes host antiviral defense by driving GEF-H1–mediated TBK1 activation

Xingmei Qi, Xue Zhu, Wenbiao Peng, Luoxue Hua, Xinru Xie, Chuncan Si, Meimei Lan, Zifan Zhuang, Siyi Ding, Ting Xu, Junjie Li, Yundi Zhang, Yifan Song, Yiping Yang, Yixue Cheng, Tao Guo, Linchao Li, Kezhen Wang

PLOS Pathogens: published October 27, 2026 | https://doi.org/10.1371/journal.ppat.1014701

Defective viral genomes of porcine reproductive and respiratory syndrome virus type 2: Generation, characterization and interference effects on viral replication

Hao Song, Guoqing Liu, Yongbo Yang, Meng Chen, Haojie Wang, Zeqing Liu, Xinyi Huang, Tongqing An

PLOS Pathogens: published October 28, 2026 | https://doi.org/10.1371/journal.ppat.1014755

Controlled human infection with Plasmodium falciparum-infected mosquito bites elicits antibodies against mosquito salivary protein SG1L3

Carolina M. Andrade, Renate C. van Daalen, Amanda Fabra-García, Sanne Grievink, Geert-Jan van Gemert, Karina Teelen, Svenja S. Hester, Rianne Stoter, Marga van de Vegte-Bolmer, Chris Drakeley, Alfred B. Tiono, Robert W. Sauerwein, Teun Bousema, Matthijs M. Jore

PLOS Pathogens: published October 28, 2026 | https://doi.org/10.1371/journal.ppat.1014719

Type III CI factors from wAlbB induce cytoplasmic incompatibility via a Host Modification mechanism

Xinjun Hou, Feng Guang Goh, Sen Liu, Yao Liu, Xin Ee Yong, Qingsong Lin, Yu Cai

PLOS Pathogens: published October 29, 2026 | https://doi.org/10.1371/journal.ppat.1014760

Phagocytosis of SARS-CoV-2 nucleocapsid- and RNA-containing immune complexes drives inflammatory cytokine production and endothelial dysfunction

Johannes S. Gach, Daniel Kim, Khoa Vu, Michaela Marshall, Christopher Cachay, Aminah A. Rangwala, Gius Kerster, Delia Tifrea, Eric Pearlman, Matthew Zahn, Marit J. van Gils, Christopher C. W. Hughes, Donald N. Forthal

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1. Targeted lysosomal activation in bladder epithelium enhances clearance of intracellular uropathogenic Escherichia coli