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Transmission electron micrograph shows a germinated microsporidian spore adjacent to a host cell, with a polar tube extending to transfer sporoplasm into the host cytoplasm. The study identified EnP1, a nucleus-targeted effector secreted by microsporidia, which enhances their proliferation by interacting with host histone H2A and inhibiting ferroptosis. This research highlights how microsporidia alter host cell functions through secreted effector proteins, ultimately facilitating their own survival and contributing to disease progression. Guan et al. 2026

Image Credit: Bing Han

Pearls

Viral proteins as discovery tools for cell biology: The case of the geminivirus-encoded C4

Shaojun Pan, Hua Wei, Frederik Dröst, Amit Fenn, Nadia Kamal, Rosa Lozano-Durán

PLOS Pathogens: published January 5, 2026 | https://doi.org/10.1371/journal.ppat.1013798

Diversify and conquer: How effector diversity is shaped by host–microbe co-evolution

Marion C. Müller, Sabine Brumm, Yiheng Hu, Eric Kemen, Thomas Lahaye, Ralph Hückelhoven

PLOS Pathogens: published January 23, 2026 | https://doi.org/10.1371/journal.ppat.1013870

Oo-No: Ophidiomyces ophidiicola-bacterial interactions and the role of skin lipids in development of ophidiomycosis

Jason W. Dallas, Mitra Ghotbi, Alexander J. Rurik, Tia King, Ross T. Rubin, Chloe Cummins, N. Reed Alexander, Tatyana A. Martinez, Ian B. Wilson, Emily Foster, Misael Avalos Madera, Johanna E. Crick, Donald M. Walker

PLOS Pathogens: published January 23, 2026 | https://doi.org/10.1371/journal.ppat.1013875

Abscisic acid at the crossroad of abiotic stress responses and plant-microbe interactions

Athanasios Makris, Beril Daloglu, Caroline Gutjahr, Martina K. Ried-Lasi

PLOS Pathogens: published January 23, 2026 | https://doi.org/10.1371/journal.ppat.1013872

Metarhizium anisopliae: A fungal biocontrol agent against Rhipicephalus microplus

Júlia de Fraga Sant’Ana, Lucélia Santi, Walter Orlando Beys-da-Silva

PLOS Pathogens: published January 30, 2026 | https://doi.org/10.1371/journal.ppat.1013918

Research Articles

A BRCT domain-containing protein induced in early phagocytosis plays a crucial role in the pathogenesis of the mucoralean Rhizopus microsporus

Ghizlane Tahiri, Carlos Lax, Ulrike Binder, Jakob Scheler, Eusebio Navarro, Francisco E. Nicolás, Victoriano Garre

PLOS Pathogens: published January 2, 2026 | https://doi.org/10.1371/journal.ppat.1013653

A prophage-encoded sRNA limits phage infection of adherent-invasive E. coli

Nicole L. Pershing, Robert S. Brzozowski, Amelia K. Schmidt, Dominick R. Faith, Alex C. Joyce, Lizett Ortiz de Ora, John D. Kominsky, Annika Dankwardt, Andrew Maciver, Rickesha Bell, William S. Henriques, Shelby E. Andersen, Blake Wiedenheft, Sherwood R. Casjens, Breck A. Duerkop, June L. Round, Patrick R. Secor

PLOS Pathogens: published January 2, 2026 | https://doi.org/10.1371/journal.ppat.1013836

Natural genetic variation of a single amino acid in beet necrotic yellow vein virus P31 protein modulates evasion of plant ubiquitination-mediated antiviral immunity

Zhi-Hong Guo, Xin-Yu Qin, Meng-Ke Zhou, Xiu-Qi Zhang, Zhi-Yao Li, Chuan Zheng, Zong-Ying Zhang, Qian Chen, Xian-Bing Wang, Cheng-Gui Han, Ying Wang

PLOS Pathogens: published January 2, 2026 | https://doi.org/10.1371/journal.ppat.1013840

Targeting of interaction between BB0323-BB0238 informs new paradigms in Lyme disease therapeutics

Sandhya Bista, Kalvis Brangulis, Bibek Bhattachan, Shelby D. Foor, Michael H. Ronzetti, Sankalp Jain, Jenna Miller, Jothy Lachumy Subramanion, Chrysoula Kitsou, Vipin S. Rana, Ganesha Rai, Alexey V. Zakharov, Anton Simeonov, Bolormaa Baljinnyam, Utpal Pal

PLOS Pathogens: published January 2, 2026 | https://doi.org/10.1371/journal.ppat.1013805

piR-bmo-796514 facilitates the proliferation of exogenous DNA virus (baculovirus) by targeting the host E3 ubiquitin ligase RNF181

Junming Xia, Shigang Fei, Wenjie Luo, Mingyang Zhou, Yibing Kong, Yigui Huang, Luc Swevers, Min Feng

PLOS Pathogens: published January 6, 2026 | https://doi.org/10.1371/journal.ppat.1013848

Structural basis for human DPP4 receptor recognition by MERS-like coronaviruses 2014-422 and GX2012

Zichun Lin, Teng Gao, Xinquan Wang

PLOS Pathogens: published January 7, 2026 | https://doi.org/10.1371/journal.ppat.1013792

Evaluating modes of influenza transmission (EMIT-2): Insights from lack of transmission in a controlled transmission trial with naturally infected donors

Jianyu Lai, Hamed Sobhani, Kristen K. Coleman, Shih-Han Sheldon Tai, Filbert Hong, Isabel Sierra Maldonado, Yi Esparza, Kathleen M. McPhaul, Shengwei Zhu, Don L. DeVoe, Justin R. Ortiz, Shuo Chen, Temima Yellin, Juan Manuel Carreno, Florian Krammer, Benjamin J. Cowling, Aubree Gordon, Wilbur H. Chen, Jelena Srebric, Donald K. Milton, for the EMIT-2 Study Team

PLOS Pathogens: published January 7, 2026 | https://doi.org/10.1371/journal.ppat.1013153

Monoclonal neutralizing antibodies elicited by infection with Kaposi sarcoma-associated herpesvirus reveal critical sites of vulnerability on gH/gL

Yu-Hsin Wan, Sara Pernikoff, Nicholas T. Aldridge, Kevin Lang, Holly M. Dudley, Samuel C. Scharffenberger, Gargi Kher, Warren Phipps, Marie Pancera, Jim Boonyaratanakornkit, Andrew T. McGuire

PLOS Pathogens: published January 7, 2026 | https://doi.org/10.1371/journal.ppat.1013772

cGAS-STING dependent type I IFN reduces Leptospira interrogans renal colonization in mice

Suman Gupta, James Matsunaga, Bridget Ratitong, Andrew Manion, Sana Ismaeel, Diogo G. Valadares, A. Phillip West, Nagaraj Kerur, Christian Stehlik, Andrea Dorfleutner, Jargalsaikhan Dagvadorj, Jenifer Coburn, Andrea J. Wolf, Meghan A. Morrissey, Suzanne L. Cassel, David A. Haake, Fayyaz S. Sutterwala

PLOS Pathogens: published January 7, 2026 | https://doi.org/10.1371/journal.ppat.1013250

EnP1 exploits H2Aub-dependent epigenetic reprogramming to promote microsporidia proliferation in host cells

Jingyu Guan, Yongliang Wang, Ming Fu, Liyuan Tang, Musa Makongoro Sabi, Huimin Zhu, Hua Cong, Chunxue Zhou, Huaiyu Zhou, Hongnan Qu, Bing Han

PLOS Pathogens: published January 7, 2026 | https://doi.org/10.1371/journal.ppat.1013853

Serine protease-driven entry and S2 ′ cleavage flexibility of feline coronavirus during feline enterocyte infections

Bixia Chen, Luna Vanden Buijs, Nathalie Vanderheijden, Lowiese Desmarets, Jolien Van Cleemput, Hans J. Nauwynck

PLOS Pathogens: published January 8, 2026 | https://doi.org/10.1371/journal.ppat.1013854

Arginine metabolism has a pivotal function for the encystation of Giardia duodenalis

Christian Klotz, Ricarda Leisering, Kari D. Hagen, Hannah N. Starcevich, Antonia Müller, Christoph Ewald, Samuel Türken, Malte Marquardt, Saskia Schramm, Totta Ehret Kasemo, Stefanie Marek, Frank Seeber, Ralf Ignatius, Scott C. Dawson, Toni Aebischer

PLOS Pathogens: published January 8, 2026 | https://doi.org/10.1371/journal.ppat.1013851

Exonuclease ISG20 inhibits human cytomegalovirus replication by inducing an innate immune defense signature

Matthias Hehl, Myriam Scherer, Cora Stegmann, Eva-Maria Raubuch, Claudia Ploil, Teresa Rummel, Philipp Kirchner, Nina Kottmann, Anna Reichel, Anna Katharina Kuderna, Anne-Charlotte König, Caroline C. Friedel, Florian Erhard, Thomas Stamminger

PLOS Pathogens: published January 9, 2026 | https://doi.org/10.1371/journal.ppat.1013856

Basal IFNλ2/3 signaling is required for ISG expression and viral control in human intestinal epithelial cells

Yagmur Keser, Zehra Sena Bumin, Amelia Perez Valiente, Sorin O. Jacobs, Steeve Boulant, Megan L. Stanifer

PLOS Pathogens: published January 12, 2026 | https://doi.org/10.1371/journal.ppat.1013857

Inapparent maternal ZIKV infection impacts fetal brain development and postnatal behavior

Tsui-Wen Chou, Micheal McCourt, Eduard Marmut, Vishal Karuppusamy, Marissa Lindman, Irving Estevez, Benjamin D. Buckley, Joshua K. Thackray, Kailyn Rodriguez, Marialaina Nissenbaum, Charul Mishra, Colm Atkins, Alexander W. Kusnecov, Max A. Tischfield, Brian P. Daniels

PLOS Pathogens: published January 12, 2026 | https://doi.org/10.1371/journal.ppat.1013850

Lumpy skin disease virus protein LSDV122 impairs IFN-I receptor complex formation to evade host innate immunity

Meng-Yao Sun, Li-Bo Cao, Qin-Ling Wan, Zhen-Zhen Li, Jun-Zheng Du, Hong-Bing Shu, Yu-Lin Yang

PLOS Pathogens: published January 12, 2026 | https://doi.org/10.1371/journal.ppat.1013871

Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions

Kathryn S. Beauchemin, Judit Kun, Bradley Groveman, Katie Williams, Francesca Salerno, Lisa M. Francomacaro, Patrick Robison, Cathryn L. Haigh, Surachai Supattapone

PLOS Pathogens: published January 12, 2026 | https://doi.org/10.1371/journal.ppat.1013867

HIV-1 derived oligonucleotides induce a type I IFN/STING dependent immune suppression reversible by targeting IFNARI

Cecilia Svanberg, Ravi Prasad Mukku, Sabri O. Besler, Francis R. Hopkins, Christopher Sjöwall, Sofia Nyström, Esaki M. Shankar, Marie Larsson

PLOS Pathogens: published January 13, 2026 | https://doi.org/10.1371/journal.ppat.1013868

Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes

Ghazal Sadri, Steven T. Nadakal, William Lauer, Justin Kos, Parmit K. Singh, Erin Elliott, Catherine W. Kaiser, Easton E. Ford, Nadia Richardson, Kaitlyn M. Shields, Elizabeth Hudson, Noemi L. Linden, Ali Danesh, James Powell, Peter Warburton, Juan Soto, Matthew Emery, Gintaras Deikus, Guinevere Q. Lee, Susanna L. Lamers, Steven J. Reynolds, Ronald Galiwango, Jessica L. Prodger, Stephen Tomusange, Taddeo Kityamuweesi, Tina Han, R. Brad Jones, Aaron A. R. Tobian, Alan N. Engelman, Robert Sebra, Susan Morgello, Andrew D. Redd, David Sachs, Eric Rouchka, Melissa L. Smith

PLOS Pathogens: published January 13, 2026 | https://doi.org/10.1371/journal.ppat.1013171

Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity

Rise Kurokawa, Chatherine Silas Mtali, Innocent John Daniel, Thorbjorg Einarsdottir, Omnia Reda, Nobuko Irie, Wajihah Sakhor, Koki Niimura, Mitsuyoshi Takatori, Kenji Sugata, Chanidapa Adele Tye, Yorifumi Satou, Masahiro Ono, Takushi Nomura

PLOS Pathogens: published January 14, 2026 | https://doi.org/10.1371/journal.ppat.1013866

Structural mapping of NTCP distinguishes its dual functionality as a hepatitis B virus receptor and bile acid transporter

Kayo Matsuzawa, Toru Ekimoto, Chisa Kobayashi, Kaho Shionoya, Junki Mifune, Takeshi Morita, Junko S. Takeuchi, Sam-Yong Park, Mitsunori Ikeguchi, Camille Sureau, Atsushi Kawaguchi, Koichi Watashi

PLOS Pathogens: published January 16, 2026 | https://doi.org/10.1371/journal.ppat.1013824

Plant rhabdovirus glycoprotein activates unfolded protein response-mediated antiviral ER-phagy in insect vectors

Siyu Chen, Yu Cheng, Yupeng Tang, Jian Zhang, You Li, Dongsheng Jia, Hongyan Chen, Taiyun Wei

PLOS Pathogens: published January 16, 2026 | https://doi.org/10.1371/journal.ppat.1013888

Multifaceted B cell response to transient HIV viremia in elite controllers

Luke Muir, Ondrej Suchanek, Peter Thomas, Sarah A. Griffith, Emma Touizer, Chloe Rees-Spear, Robert Krause, Masahiro Yoshida, Christopher L. Pinder, Rutuja Patil, Marko Z. Nikolic, Katie J. Doores, Marit J. Van Gils, Alasdair Leslie, Alex Sigal, Ravindra K. Gupta, Menna R. Clatworthy, Laura E. McCoy

PLOS Pathogens: published January 16, 2026 | https://doi.org/10.1371/journal.ppat.1013817

Structure of defense against restriction proteins DarA and Hdf in phage P1 reveals a new molecular mechanism during phage assembly, infection and DNA ejection

Jing Zheng, Yuan Chen, Siting Chen, Junquan Zhou, Hao Xiao, Fan Yang, Hongrong Liu

PLOS Pathogens: published January 16, 2026 | https://doi.org/10.1371/journal.ppat.1013869

Carbapenem resistant Klebsiella pneumoniae isolates at a tertiary hospital in Cape Town, South Africa, are dominated by specific local clones rather than previously described international lineages

Kedišaletše Moloto, Mae Newton-Foot, Angela Dramowski, Stefany Ayala-Montaño, Ifeoluwa Akintayo, Andrew Whitelaw, Sandra Reuter

PLOS Pathogens: published January 16, 2026 | https://doi.org/10.1371/journal.ppat.1013859

Nucleus softens during herpesvirus infection

Aapo Tervonen, Visa Ruokolainen, Simon Leclerc, Katie Tieu, Sébastien Lyonnais, Henri Niskanen, Jian-Hua Chen, Alka Gupta, Minna U. Kaikkonen, Carolyn A. Larabell, Delphine Muriaux, Salla Mattola, Daniel E. Conway, Teemu O. Ihalainen, Vesa Aho, Maija Vihinen-Ranta

PLOS Pathogens: published January 20, 2026 | https://doi.org/10.1371/journal.ppat.1013873

Purifying selection constrains the evolution of Juquitiba virus in wild Oligoryzomys nigripes communities

Briana Spruill-Harrell, Alejandro Ponce-Flores, Evans Ifebuche Nnamani, Robert D. Owen, Michael A. Whitt, Colleen B. Jonsson

PLOS Pathogens: published January 20, 2026 | https://doi.org/10.1371/journal.ppat.1013839

Peptidoglycan architecture dictates protein interactions, tissue tropism, and arthritis in the Lyme disease spirochete Borrelia burgdorferi

Saadman S. Ahmad, Osamudiamen Ebohon, Mecaila E. McClune, Rebecca N. Trimble, Casey N. Kellogg, Carmen J. Booth, Wolfram R. Zückert, Brandon L. Jutras

PLOS Pathogens: published January 20, 2026 | https://doi.org/10.1371/journal.ppat.1013849

The Oxylipin Dependent Quorum Sensing System enhances Pseudomonas aeruginosa dissemination during burn-associated infection

Eriel Martínez, Hansol Im, Mohammed Mohasin, Landon Wilson, Javier Campos-Gomez, Carlos J. Orihuela

PLOS Pathogens: published January 20, 2026 | https://doi.org/10.1371/journal.ppat.1013885

The receptor binding properties of H5Ny influenza A viruses have evolved to bind to avian-type mucin-like O-glycans

Julia Weber, Niels L. D. Ponse, Xueyong Zhu, María Ríos Carrasco, Alvin X. Han, Mathis Funk, Ting-Hui Lin, Alba Gabarroca García, Cindy M. Spruit, Ding Zhang, Wenli Yu, Ian A. Wilson, Mathilde Richard, Geert-Jan Boons, Robert P. de Vries

PLOS Pathogens: published January 20, 2026 | https://doi.org/10.1371/journal.ppat.1013812

Acetylation dynamics of MrATG4 governing autophagy-mediated conidiation in an entomopathogenic fungus

Deshui Yu, Yulong Wang, Rui Xie, Rong Zhou, Zhenbang Liu, Najie Shi, Xiangyun Xie, Yang Yang, Jiaojiao Qu, Guang Yang, Bo Huang

PLOS Pathogens: published January 20, 2026 | https://doi.org/10.1371/journal.ppat.1013883

Fecal microbiota transplantation ameliorates radiation-induced lung injury by reshaping gut metabolic homeostasis to activate FAM134B-mediated ER-phagy

Xiaoyu Pu, Bohao Liu, Lihua Dong, Meng Yuan, Shunzi Jin, Xin Jiang

PLOS Pathogens: published January 21, 2026 | https://doi.org/10.1371/journal.ppat.1013786

Palmitoylation of the human cytomegalovirus tegument protein pp28 facilitates virus release

Jae Bong Lee, Naeok Koo, Ji Min Park, Jun-Young Seo

PLOS Pathogens: published January 22, 2026 | https://doi.org/10.1371/journal.ppat.1013894

Exogenous amdoparvoviruses (Parvoviridae) in arvicoline voles: the molecular evolution and ecology of a novel host-viral association

Joseph A. Jackson, Mike Begon, Janette E. Bradley, Ida M. Friberg, Sarah Hyde, Klara M. Wanelik, Steve Paterson

PLOS Pathogens: published January 22, 2026 | https://doi.org/10.1371/journal.ppat.1013896

Molecular mechanism of ziresovir targeting the fusion glycoprotein of respiratory syncytial virus

Mengrong Yan, Jingjing Zou, Zhao Gao, Haiqing Yuan, Jim Zhen Wu, Gang Zou, Fengjiang Liu, Wei Peng

PLOS Pathogens: published January 23, 2026 | https://doi.org/10.1371/journal.ppat.1013864

Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection

Yohei Watanabe, Madiha S. Ibrahim, Yasuha Arai, Daisuke Kuroda, Emad M. Elgendy, Shin-ichi Nakakita, Yohei Takeda, Vuong Nghia Bui, Takao Ono, Shota Ushiba, Tomo Daidoji, Nongluk Sriwilaijaroen, Haruko Ogawa, Kazuhiko Matsumoto, Yasuo Suzuki, Takaaki Nakaya

PLOS Pathogens: published January 23, 2026 | https://doi.org/10.1371/journal.ppat.1013863

Epstein-barr virus latent membrane protein 1 targets cIAP1, cIAP2 and TRAF2 for proteasomal degradation to activate the non-canonical NF-κB pathway

Yizhe Sun, Shunji Li, Bidisha Mitra, Ling Zhong, Aretina Zhang, Benjamin E. Gewurz

PLOS Pathogens: published January 26, 2026 | https://doi.org/10.1371/journal.ppat.1013898

Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase

Zuxin Gong, Jiaqi Dai, Hailong Qu, Yongxin Hu, Fanqi Sun, Chenchen Liu, Xin Li, Chunyan Feng, Zhiliang Wang, Zhen Yang, Gongguan Liu

PLOS Pathogens: published January 26, 2026 | https://doi.org/10.1371/journal.ppat.1013903

The βC1 protein encoded in betasatellites promotes begomovirus-whitefly coexistence by subverting vector infestation-induced plant antiviral defenses

Shi-Xing Zhao, Yi-Ming Liu, Su-Dan Wang, Xiao-Wei Wang, Shu-Sheng Liu, Yin-Quan Liu, Li-Long Pan

PLOS Pathogens: published January 26, 2026 | https://doi.org/10.1371/journal.ppat.1013907

De novo nucleotide biosynthesis and its dynamic regulation are crucial for systemic infection by extraintestinal Escherichia coli

Chu Zhang, Yi Yang, Shuang Wang, Yuying Liu, Xianglin Zhao, Fan Yin, Yawen Hu, Ying Xue, Zixuan Bu, Shaowen Li, Chen Tan, Rui Zhou, Qi Huang

PLOS Pathogens: published January 26, 2026 | https://doi.org/10.1371/journal.ppat.1013889

HCMV encoded UL84 hijacks FHL2 to suppress type I interferon production and enhance viral replication

Ruilin Li, Sisi Xia, Xin Li, Ying Zeng, Tianqi Wang, Chuan Xia, Hongjian Li, Jun Chen

PLOS Pathogens: published January 26, 2026 | https://doi.org/10.1371/journal.ppat.1013895

Tissue-resident macrophage and dendritic cells drive type I IFN immunity to enteroviruses in the liver

Emma Heckenberg, Jacob G. Davis, Caitlin Hale, Carolyn B. Coyne

PLOS Pathogens: published January 27, 2026 | https://doi.org/10.1371/journal.ppat.1013891

Pfs48/45 nanobodies block Plasmodium falciparum transmission

Frankie M. T. Lyons, Jill Chmielewski, Mikha Gabriela, Li-Jin Chan, Joshua Tong, Amy Adair, Kathleen Zeglinski, Quentin Gouil, Melanie H. Dietrich, Wai-Hong Tham

PLOS Pathogens: published January 27, 2026 | https://doi.org/10.1371/journal.ppat.1013884

A highly potent and broadly accessible bispecific nanobody for the treatment of ebola virus infections

Fan Bu, Gang Ye, Kimberly Morsheimer, Hailey Turner-Hubbard, Brett Eaton, Manu Anantpadma, Khaggeswar Bheemanapally, Chalet Tan, Robert Davey, Fang Li

PLOS Pathogens: published January 27, 2026 | https://doi.org/10.1371/journal.ppat.1013878

White spot syndrome virus IE1 protein hijacks the host pentose phosphate pathway to fuel viral replication

Jia Zhang, Kaiyu Lu, Jinghua Zhu, Jude Juventus Aweya, Yueling Zhang, Defu Yao

PLOS Pathogens: published January 27, 2026 | https://doi.org/10.1371/journal.ppat.1013913

A Spinster-like Transporter at the Inner Membrane Complex is critical for Toxoplasma gondii cytokinesis, motility and invasion

Syrian G. Sanchez, Romuald Haase, David J. Dubois, Margaux Héritier, Rachel Humann, Nicolas Hulo, Bohumil Maco, Isabel Meister, Leonardo Scapozza, Oscar Vadas, Dominique Soldati-Favre

PLOS Pathogens: published January 28, 2026 | https://doi.org/10.1371/journal.ppat.1013886

Membrane-anchored PrP^Sc is the trigger for prion synaptotoxicity

Jean R. P. Gatdula, Robert C. C. Mercer, Jose Andres Alepuz Guillen, Janelle S. Vultaggio, David A. Harris

PLOS Pathogens: published January 28, 2026 | https://doi.org/10.1371/journal.ppat.1013911

Examining the role of IgA in a persistent model of Staphylococcus aureus colonization

Yunys Perez-Betancourt, Miaomiao Shi, Dominique Missiakas

PLOS Pathogens: published January 28, 2026 | https://doi.org/10.1371/journal.ppat.1013924

The effect of combining HIV latency reversal with inhibition of phosphoinositide-3 kinases or B-cell lymphoma-2 on the HIV reservoir

Youry Kim, Jenny L. Anderson, Carolin Tumpach, Ajantha Solomon, Jesslyn Ong, Kiho Tanaka, Jennifer M. Zerbato, Tania Tan, Charis E. Teh, Daniel H. D. Gray, Philip Arandjelovic, James McMahon, Niamh Meagher, David Price, Marc Pellegrini, Michael Roche, Sharon R. Lewin

PLOS Pathogens: published January 29, 2026 | https://doi.org/10.1371/journal.ppat.1013923

YAP Inhibits HIV-1 transcription and promotes HIV-1 latency by regulating E3 ubiquitin ligase UHRF1 mediated tat degradation

Chenliang Zhou, Hong He, Yuzai Zhang, Xiaolian Liu, Muye Xia, Jiayin Qiu, Ziyao Wu, Huba Khamis Rashid, Wenli Liu, Jie Peng, Lin Li

PLOS Pathogens: published January 30, 2026 | https://doi.org/10.1371/journal.ppat.1013906

Correction

Correction: Systemic Expression of Kaposi Sarcoma Herpesvirus (KSHV) Vflip in Endothelial Cells Leads to a Profound Proinflammatory Phenotype and Myeloid Lineage Remodeling In Vivo

Gianna Ballon, Gunkut Akar, Ethel Cesarman

PLOS Pathogens: published January 5, 2026 | https://doi.org/10.1371/journal.ppat.1013809

Retractions

Retraction: The Downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 Axis and by Human Cytomegalovirus (HCMV) Associated Factors Allows the Activation of the HCMV Major IE Promoter and the Transition to Productive Infection

The PLOS Pathogens Editors

PLOS Pathogens: published January 5, 2026 | https://doi.org/10.1371/journal.ppat.1013827

Retraction: Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation

The PLOS Pathogens Editors

PLOS Pathogens: published January 21, 2026 | https://doi.org/10.1371/journal.ppat.1013877

Short Reports

Broadly neutralizing antibody responses in a Chinese acute HIV-1 infection cohort of men who have sex with men

Linhong Yao, Yang Gao, Wen Tian, Haibo Ding, Hong Shang, Xiaoxu Han

PLOS Pathogens: published January 2, 2026 | https://doi.org/10.1371/journal.ppat.1013822

January 2026

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A Germinated Microsporidian Spore in Close Proximity to the Host Cell Surface

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