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Table of Contents

July 2020

The capsid structure of murine noroviruses changes in response to aqueous conditions. By twisting the flexible hinge connecting two domains, the protruding (P) domain reversibly rises off the shell (S) domain in solutions of higher pH, but rests on the S domain in solutions of lower pH. Metal ions help to stabilize the resting conformation in this process. This image shows the two structures of the norovirus reconstructed by cryo-electron microscopy and the morphology of the resting or rising P domains on the S domain. Song et al.

Image Credit: Song C, Murata K (2020)

Pearls

An urge to fill a knowledge void: Malaria parasites are rarely investigated in threatened species

María Cristina Carmona-Isunza, Sergio Ancona, Jordi Figuerola, Alejandro Gonzalez-Voyer, Josué Martínez de la Puente

Peroxisomes in host defense

Francesca Di Cara

Whoop! There it is: The surprising resurgence of pertussis

Audra R. Fullen, Kacy S. Yount, Purnima Dubey, Rajendar Deora

Candida auris in the UK: Introduction, dissemination, and control

Andrew M. Borman, Elizabeth M. Johnson

Reviews

Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance

Rafael C. M. C. Silva, Leonardo H. Travassos, Claudia N. Paiva, Marcelo T. Bozza

Interplay between SARS-CoV-2 and the type I interferon response

Margarida Sa Ribero, Nolwenn Jouvenet, Marlène Dreux, Sébastien Nisole

Research Articles

Dynamic rotation of the protruding domain enhances the infectivity of norovirus

Chihong Song, Reiko Takai-Todaka, Motohiro Miki, Kei Haga, Akira Fujimoto, Ryoka Ishiyama, Kazuki Oikawa, Masaru Yokoyama, Naoyuki Miyazaki, Kenji Iwasaki, Kosuke Murakami, Kazuhiko Katayama, Kazuyoshi Murata

Zika virus tropism during early infection of the testicular interstitium and its role in viral pathogenesis in the testes

Konstantin A. Tsetsarkin, Joshua A. Acklin, Guangping Liu, Heather Kenney, Natalia L. Teterina, Alexander G. Pletnev, Jean K. Lim

Campylobacter jejuni motility integrates specialized cell shape, flagellar filament, and motor, to coordinate action of its opposed flagella

Eli J. Cohen, Daisuke Nakane, Yoshiki Kabata, David R. Hendrixson, Takayuki Nishizaka, Morgan Beeby

Single cell heterogeneity in influenza A virus gene expression shapes the innate antiviral response to infection

Jiayi Sun, J. Cristobal Vera, Jenny Drnevich, Yen Ting Lin, Ruian Ke, Christopher B. Brooke

Pyrrocidine, a molecular off switch for fumonisin biosynthesis

Minglu Gao, Anthony E. Glenn, Xi Gu, Trevor R. Mitchell, Timothy Satterlee, Mary V. Duke, Brian E. Scheffler, Scott E. Gold

A Toxoplasma gondii patatin-like phospholipase contributes to host cell invasion

Sarah K. Wilson, Justine Heckendorn, Bruno Martorelli Di Genova, Lindsey L. Koch, Peggy J. Rooney, Naomi Morrissette, Maryse Lebrun, Laura J. Knoll

TLR2 and endosomal TLR-mediated secretion of IL-10 and immune suppression in response to phagosome-confined Listeria monocytogenes

Brittney N. Nguyen, Alfredo Chávez-Arroyo, Mandy I. Cheng, Maria Krasilnikov, Alexander Louie, Daniel A. Portnoy

Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation

Christian Sieben, Erdinc Sezgin, Christian Eggeling, Suliana Manley

The endosymbiont Wolbachia rebounds following antibiotic treatment

Emma L. Gunderson, Ian Vogel, Laura Chappell, Christina A. Bulman, K. C. Lim, Mona Luo, Jeffrey D. Whitman, Chris Franklin, Young-Jun Choi, Emilie Lefoulon, Travis Clark, Brenda Beerntsen, Barton Slatko, Makedonka Mitreva, William Sullivan, Judy A. Sakanari

In vivo synthesis of bacterial amyloid curli contributes to joint inflammation during S. Typhimurium infection

Amanda L. Miller, J. Alex Pasternak, Nicole J. Medeiros, Lauren K. Nicastro, Sarah A. Tursi, Elizabeth G. Hansen, Ryan Krochak, Akosiererem S. Sokaribo, Keith D. MacKenzie, Melissa B. Palmer, Dakoda J. Herman, Nikole L. Watson, Yi Zhang, Heather L. Wilson, R. Paul Wilson, Aaron P. White, Çagla Tükel

Androgen receptor signaling in the lungs mitigates inflammation and improves the outcome of influenza in mice

Landon G. vom Steeg, Santosh Dhakal, Yishak A. Woldetsadik, Han-Sol Park, Kathleen R. Mulka, Emma C. Reilly, David J. Topham, Sabra L. Klein

Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death

Megan Steain, Max O. D. G. Baker, Chi L. L. Pham, Nirukshan Shanmugam, Yann Gambin, Emma Sierecki, Brian P. McSharry, Selmir Avdic, Barry Slobedman, Margaret Sunde, Allison Abendroth

Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis

Joy E. Tomlinson, Raphael Wolfisberg, Ulrik Fahnøe, Himanshu Sharma, Randall Renshaw, Louise Nielsen, Eiko Nishiuchi, Christina Holm, Edward Dubovi, Brad R. Rosenberg, Bud C. Tennant, Jens Bukh, Amit Kapoor, Thomas J. Divers, Charles M. Rice, Gerlinde R. Van de Walle, Troels K. H. Scheel

HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling

Zhixuan Loh, Jennifer Simpson, Ashik Ullah, Vivian Zhang, Wan J. Gan, Jason P. Lynch, Rhiannon B. Werder, Al Amin Sikder, Katie Lane, Choon Boon Sim, Enzo Porrello, Stuart B. Mazzone, Peter D. Sly, Raymond J. Steptoe, Kirsten M. Spann, Maria B. Sukkar, John W. Upham, Simon Phipps

A trafficome-wide RNAi screen reveals deployment of early and late secretory host proteins and the entire late endo-/lysosomal vesicle fusion machinery by intracellular Salmonella

Alexander Kehl, Vera Göser, Tatjana Reuter, Viktoria Liss, Maximilian Franke, Christopher John, Christian P. Richter, Jörg Deiwick, Michael Hensel

Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment

Jonathan S. Nguyen-Van-Tam, Ben Killingley, Joanne Enstone, Michael Hewitt, Jovan Pantelic, Michael L. Grantham, P. Jacob Bueno de Mesquita, Robert Lambkin-Williams, Anthony Gilbert, Alexander Mann, John Forni, Catherine J. Noakes, Min Z. Levine, LaShondra Berman, Stephen Lindstrom, Simon Cauchemez, Werner Bischoff, Raymond Tellier, Donald K. Milton, for the EMIT Consortium

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV

Sebastian J. Theobald, Christoph Kreer, Sahamoddin Khailaie, Agnes Bonifacius, Britta Eiz-Vesper, Constanca Figueiredo, Michael Mach, Marija Backovic, Matthias Ballmaier, Johannes Koenig, Henning Olbrich, Andreas Schneider, Valery Volk, Simon Danisch, Lutz Gieselmann, Meryem Seda Ercanoglu, Martin Messerle, Constantin von Kaisenberg, Torsten Witte, Frank Klawonn, Michael Meyer-Hermann, Florian Klein, Renata Stripecke

The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence

Laure N. A. Ries, Lakhansing Pardeshi, Zhiqiang Dong, Kaeling Tan, Jacob L. Steenwyk, Ana Cristina Colabardini, Jaire A. Ferreira Filho, Patricia A. de Castro, Lilian P. Silva, Nycolas W. Preite, Fausto Almeida, Leandro J. de Assis, Renato A. C. dos Santos, Paul Bowyer, Michael Bromley, Rebecca A. Owens, Sean Doyle, Marilene Demasi, Diego C. R. Hernández, Luís Eduardo S. Netto, Monica T. Pupo, Antonis Rokas, Flavio V. Loures, Koon H. Wong, Gustavo H. Goldman

Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression

Linda J. Visser, Chiara Aloise, Kirby N. Swatek, Gisselle N. Medina, Karin M. Olek, Huib H. Rabouw, Raoul J. de Groot, Martijn A. Langereis, Teresa de los Santos, David Komander, Tim Skern, Frank J. M. van Kuppeveld

Contained Mycobacterium tuberculosis infection induces concomitant and heterologous protection

Johannes Nemeth, Gregory S. Olson, Alissa C. Rothchild, Ana N. Jahn, Dat Mai, Fergal J. Duffy, Jared L. Delahaye, Sanjay Srivatsan, Courtney R. Plumlee, Kevin B. Urdahl, Elizabeth S. Gold, Alan Aderem, Alan H. Diercks

Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity

Elsa Ghirardini, Elena Restelli, Raffaella Morini, Ilaria Bertani, Davide Ortolan, Fabio Perrucci, Davide Pozzi, Michela Matteoli, Roberto Chiesa

Ancient co-option of an amino acid ABC transporter locus in Pseudomonas syringae for host signal-dependent virulence gene regulation

Qing Yan, Conner J. Rogan, Yin-Yuin Pang, Edward W. Davis II, Jeffrey C. Anderson

AHR is a tunable knob that controls HTLV-1 latency-reactivation switching

Weihao Hong, Wenzhao Cheng, Tingjin Zheng, Nan Jiang, Ruian Xu

Structural basis for the interaction of human herpesvirus 6B tetrameric glycoprotein complex with the cellular receptor, human CD134

Mitsuhiro Nishimura, Bernadette Dian Novita, Takayuki Kato, Lidya Handayani Tjan, Bochao Wang, Aika Wakata, Anna Lystia Poetranto, Akiko Kawabata, Huamin Tang, Taiki Aoshi, Yasuko Mori

Inhibition of spumavirus gene expression by PHF11

Melissa Kane, Vincent Mele, Rachel A. Liberatore, Paul D. Bieniasz

Tetrameric glycoprotein complex gH/gL/gQ1/gQ2 is a promising vaccine candidate for human herpesvirus 6B

Bochao Wang, Kouichi Hara, Akiko Kawabata, Mitsuhiro Nishimura, Aika Wakata, Lidya Handayani Tjan, Anna Lystia Poetranto, Chisato Yamamoto, Yasunari Haseda, Taiki Aoshi, Lisa Munakata, Ryo Suzuki, Masato Komatsu, Ryuko Tsukamoto, Tomoo Itoh, Chikako Nishigori, Yasuyuki Saito, Takashi Matozaki, Yasuko Mori

Pressurized DNA state inside herpes capsids—A novel antiviral target

Alberto Brandariz-Nuñez, Scott J. Robinson, Alex Evilevitch

Life course exposures continually shape antibody profiles and risk of seroconversion to influenza

Bingyi Yang, Justin Lessler, Huachen Zhu, Chao Qiang Jiang, Jonathan M. Read, James A. Hay, Kin On Kwok, Ruiyin Shen, Yi Guan, Steven Riley, Derek A. T. Cummings

Host prion protein expression levels impact prion tropism for the spleen

Vincent Béringue, Philippe Tixador, Olivier Andréoletti, Fabienne Reine, Johan Castille, Thanh-Lan Laï, Annick Le Dur, Aude Laisné, Laetitia Herzog, Bruno Passet, Human Rezaei, Jean-Luc Vilotte, Hubert Laude

Protein phosphatase 1 catalyzes HBV core protein dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids

Zhanying Hu, Haiqun Ban, Haiyan Zheng, Mingliang Liu, Jinhong Chang, Ju-Tao Guo

Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression

Viralkumar V. Panchal, Caitlin Griffiths, Hamed Mosaei, Bohdan Bilyk, Joshua A. F. Sutton, Oliver T. Carnell, David P. Hornby, Jeffrey Green, Jamie K. Hobbs, William L. Kelley, Nikolay Zenkin, Simon J. Foster

Comparative transcriptome analysis of endemic and epidemic Kaposi’s sarcoma (KS) lesions and the secondary role of HIV-1 in KS pathogenesis

Salum J. Lidenge, Andrew V. Kossenkov, For Yue Tso, Jayamanna Wickramasinghe, Sara R. Privatt, Owen Ngalamika, John R. Ngowi, Julius Mwaiselage, Paul M. Lieberman, John T. West, Charles Wood

Timelines of infection and transmission dynamics of H1N1pdm09 in swine

Laetitia Canini, Barbara Holzer, Sophie Morgan, Johanneke Dinie Hemmink, Becky Clark, sLoLa Dynamics Consortium, Mark E. J. Woolhouse, Elma Tchilian, Bryan Charleston

An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection

Kevin P. Egan, Lauren M. Hook, Alexis Naughton, Norbert Pardi, Sita Awasthi, Gary H. Cohen, Drew Weissman, Harvey M. Friedman

Novel phenotype of Wolbachia strain wPip in Aedes aegypti challenges assumptions on mechanisms of Wolbachia-mediated dengue virus inhibition

Johanna E. Fraser, Tanya B. O’Donnell, Johanna M. Duyvestyn, Scott L. O’Neill, Cameron P. Simmons, Heather A. Flores

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis

Collin R. Diedrich, Tara Rutledge, Pauline Maiello, Tonilynn M. Baranowski, Alexander G. White, H. Jacob Borish, Paul Karell, Forrest Hopkins, Jessica Brown, Sarah M. Fortune, JoAnne L. Flynn, Zandrea Ambrose, Philana Ling Lin

The Barley stripe mosaic virus γb protein promotes viral cell-to-cell movement by enhancing ATPase-mediated assembly of ribonucleoprotein movement complexes

Zhihao Jiang, Kun Zhang, Zhaolei Li, Zhenggang Li, Meng Yang, Xuejiao Jin, Qing Cao, Xueting Wang, Ning Yue, Dawei Li, Yongliang Zhang

Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation

Shuai Liu, Zhangmengxue Lei, Jie Li, Liu Wang, Ran Jia, Zhongshun Liu, Congwei Jiang, Ying Gao, Mu Liu, Linlin Kuang, Zhikang Qian, Dongming Zhou, Samuel H. Speck, Xiaozhen Liang