Fueling silence: Metabolic control of latent viral infection

Haixi You, Rui Guo

PLOS Pathogens: published April 1, 2026 | https://doi.org/10.1371/journal.ppat.1014092

Strategies in immune subversion: How Yersinia pestis inhibits neutrophil responses

Katelyn R. Sheneman, Matthew B. Lawrenz

PLOS Pathogens: published April 10, 2026 | https://doi.org/10.1371/journal.ppat.1014120

Intestinal fungi shape the biology of the mammalian gut

Elena Lindemann-Pérez, J. Christian Pérez

PLOS Pathogens: published April 13, 2026 | https://doi.org/10.1371/journal.ppat.1014132

Three paradoxical paradigms of measles virus

Stephanie E. Clark, Patrick L. Sinn

PLOS Pathogens: published April 15, 2026 | https://doi.org/10.1371/journal.ppat.1014135

Forest tree diversity is dependent on both mycorrhizal type and scale

Kathryn N. Maley, Mary Catherine Aime

PLOS Pathogens: published April 20, 2026 | https://doi.org/10.1371/journal.ppat.1014112

Anti-granulocyte macrophage colony-stimulating factor autoantibodies: A rising cause of infectious diseases

Shang-Yu Wang, Yu-Fang Lo, Yu-Huan Tsai, Cheng-Lung Ku

PLOS Pathogens: published April 20, 2026 | https://doi.org/10.1371/journal.ppat.1014116

Experimental evolution of fungal pathogens as a tool to unravel host adaptation and virulence

Paul Mathias Jansen, Bernhard Hube, Sascha Brunke

PLOS Pathogens: published April 24, 2026 | https://doi.org/10.1371/journal.ppat.1014149

Trypanosomes of fish as an emerging threat to aquaculture systems in China

Ju-Feng Wang, Xin-Tao Li, Julius Lukeš, De-Hua Lai

PLOS Pathogens: published April 28, 2026 | https://doi.org/10.1371/journal.ppat.1014129

An old foe comes swooping back: Whooping cough resurgence—Okay, now what?

Dakota L. Musgrave, C. Buddy Creech

PLOS Pathogens: published April 28, 2026 | https://doi.org/10.1371/journal.ppat.1014157

Expanding the LuxR-type receptor functional repertoire: Protein-protein interactions in quorum sensing regulation

Caleb P. Mallery, Jon E. Paczkowski

PLOS Pathogens: published April 1, 2026 | https://doi.org/10.1371/journal.ppat.1014091

Context-specific roles for IL-17 in tuberculosis

Mahlatse Maseeme, Liku B. Tezera, Mahdad Noursadeghi, Alasdair Leslie, Gabriele Pollara

PLOS Pathogens: published April 21, 2026 | https://doi.org/10.1371/journal.ppat.1014054

Mechanisms of natural and vaccine-induced immunity to Bordetella pertussis

Lisa Borkner, Caroline E. Sutton, Sreeram Udayan, Seyed Davoud Jazayeri, Kingston H. G. Mills

PLOS Pathogens: published April 24, 2026 | https://doi.org/10.1371/journal.ppat.1014128

Defining the impact of Getah virus envelope protein glycosylation site mutations on viral replication, host adaptation, virulence, and immune evasion

Tongwei Ren, Muyang Liu, Peijie Li, Liping Zhang, Zhen Zhong, Lingshan Zhou, Yifeng Qin, Kang Ouyang, Yeshi Yin, Ying Chen, Weijian Huang, Zuzhang Wei

PLOS Pathogens: published April 2, 2026 | https://doi.org/10.1371/journal.ppat.1014126

Single-cell transcriptome profiling reveals herpesviral manipulation of host processes in spleen of gibel carp infected with a Cyvirus cyprinidallo2

Fei Ke, Yu Zhou, Bo-Qian Chen, Han-Yue Wang, Zhe Zhao, Qi-Ya Zhang

PLOS Pathogens: published April 2, 2026 | https://doi.org/10.1371/journal.ppat.1014114

Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B

Donghoon Chung, Yuka Otsuka, Eunjung Kim, Sultan Ullah, Nicole M. Kennedy, Khac Huy Ngo, Jinjoo Kang, Reece Tomlinson, Brian Alejandro, Koji Barnaby, Jeffrey Miller, Justin Shumate, Chwee Fang Teo, Yaw Bia Tan, Che Shin Chew, CongBao Kang, Dahai Luo, Louis Scampavia, Timothy P. Spicer, Thomas D. Bannister

PLOS Pathogens: published April 3, 2026 | https://doi.org/10.1371/journal.ppat.1013609

Efficacy of the nucleoside analog 4′-Fluorouridine against Nipah virus in the Syrian hamster model

Olivier Escaffre, Madison L. Pearson, Terry L. Juelich, Jennifer K. Smith, Lihong Zhang, Carolin M. Lieber, Dariia Vyshenska, Tetsuro Ikegami, Griffin D. Haas, Rebecca E. Krueger, Zachary Sticher, Alexander A. Kolykhalov, Michael G. Natchus, George R. Painter, Kendra N. Johnson, Alexander L. Greninger, Robert M. Cox, Richard K. Plemper, Benhur Lee, Alexander N. Freiberg

PLOS Pathogens: published April 3, 2026 | https://doi.org/10.1371/journal.ppat.1014093

Role of the C-terminal modules of Klebsiella phage KP32 receptor-binding protein gp38 in protein and phage functionality

Agnieszka Latka, Dorien Dams, Lennert Scholiers, Aleksandra Otwinowska, Sebastian Olejniczak, Zuzanna Drulis-Kawa, Yves Briers

PLOS Pathogens: published April 6, 2026 | https://doi.org/10.1371/journal.ppat.1014106

Pigs lacking Natural Killer T cells have altered cellular responses to influenza

Taeyong Kwon, Weihong Gu, Igor Morozov, Mariano Carossino, Eu Lim Lyoo, Chester D. McDowell, Yonghai Li, Udeni B. R. Balasuriya, Yi Huang, Darling Melany De Carvahlo Madrid, Kiho Lee, Juergen A. Richt, John P. Driver

PLOS Pathogens: published April 6, 2026 | https://doi.org/10.1371/journal.ppat.1014094

Adenovirus phagocytosis by neutrophils triggers a pro-inflammatory response

Salomé Laurans, Soizic Huerre, Olivier Dellis, Céline Férard, Hadrien Jalaber, Clément Vanbergue, Emilie Brun, Rémy Jelin, Oliver Nüsse, Karim Benihoud, Sophie Dupré-Crochet

PLOS Pathogens: published April 6, 2026 | https://doi.org/10.1371/journal.ppat.1013504

Dynamics of the microbiota in patients with Clostridioides difficile: Recurrence, treatment, sex, and immunosuppression

Maria Paz Ventero, Rocio Herrero, Iryna Tyshkovska, Maria-Dolores Valverde-Fredet, Juan Carlos Rodríguez, Miguel Rodríguez-Fernández, Pilar González-De-La-Aleja, Marta Trigo, Monica Parra, Ana-Isabel Aller, Silvia Otero, Reinaldo Espindola-Gomez, José Manuel Ramos, Eva M. León, Maria García, Miguel Nicolas Navarrete-Lorite, Jara Llenas-García, Ines Portillo, Francisco Jover, Maria Tasias, Juan Jose Caston, Concepción Gil, David Vinuesa-Garcia, Cristina Gomez-Ayerbe, Francisco J. Martínez Marcos, Nicolas Merchante, Esperanza Merino De Lucas

PLOS Pathogens: published April 6, 2026 | https://doi.org/10.1371/journal.ppat.1014063

Host range and zoonotic potential linked to P-like fimbrial (PLF) adhesin specificity in avian pathogenic Escherichia coli

Fariba Akrami, Hossein Jamali, Sebastien Houle, Paula Armoa Ortiz, Charles Calmettes, Charles M. Dozois

PLOS Pathogens: published April 6, 2026 | https://doi.org/10.1371/journal.ppat.1013691

Adeno-associated virus delivery of anti-alpha toxin monoclonal antibodies confers protection against Staphylococcus aureus infections

Josefien W. Hommes, Madison E. Hughes, Derek Cheung, Björn Petri, Lindsey M. Orthner, Tristan J. van der Linden, Bart W. Bardoel, Simran K. Deo, Deepak T. Patel, Ronald S. Flannagan, David E. Heinrichs, Sarah K. Wootton, Bas G. J. Surewaard

PLOS Pathogens: published April 6, 2026 | https://doi.org/10.1371/journal.ppat.1014090

GM-CSF orchestrates monocyte and granulocyte responses to Cryptococcus gattii

Alison Ricafrente, Sreemoyee Acharya, Shuyi Chen, Adiza Abass, Aelita Arshakyan, Tyler J. Olson, Apurwa Trivedi, Lena J. Heung

PLOS Pathogens: published April 7, 2026 | https://doi.org/10.1371/journal.ppat.1013418

Generation of a HiBiT-expressing recombinant rat hepacivirus supporting both in vivo and in vitro infection

Yasunori Akaike, Tomohisa Tanaka, Hirotake Kasai, Atsuya Yamashita, Yoshiharu Matsuura, Kohji Moriishi

PLOS Pathogens: published April 8, 2026 | https://doi.org/10.1371/journal.ppat.1014127

Venezuelan equine encephalitis virus infection causes chronic neurobehavioral outcomes, cellular remodeling, and hippocampal single-cell transcriptomic changes

Morgen VanderGiessen, Elizabeth Harris, Liduo Yin, Brittany Heath, Shannon K. Carney, Caitlin M. Woodson, Xiaowei Wu, Erik Johnson, Hehuang Xie, Michelle Theus, Kylene Kehn-Hall

PLOS Pathogens: published April 8, 2026 | https://doi.org/10.1371/journal.ppat.1014115

Cetacean coronavirus spikes highlight S glycoprotein structural plasticity

Ruben J. G. Hulswit, Tatiana M. Shamorkina, Joline van der Lee, Floor Rosman, Lisanne S. Wetzels, Frank J. M. van Kuppeveld, Joost Snijder, Berend Jan Bosch, Daniel L. Hurdiss

PLOS Pathogens: published April 8, 2026 | https://doi.org/10.1371/journal.ppat.1013855

A unique Z-shaped tetramer mediates the autoinhibition of waterfowl STING

Zhenchao Zhao, Xiangyu Huang, Lei Wu, Xin Li

PLOS Pathogens: published April 8, 2026 | https://doi.org/10.1371/journal.ppat.1014111

Accumulation of mutations in nsp4, E, and the S2 subunit underlies mammalian cell tropism expansion and virulence attenuation of avian coronavirus

Yingfei Li, Xuehui Zhang, Rong Liang, Ruotong Li, Ruihua Yang, Liwei Zhang, Ye Zhao, Guozhong Zhang, Jing Zhao

PLOS Pathogens: published April 9, 2026 | https://doi.org/10.1371/journal.ppat.1014147

Cell-free RNA reveals host and microbial correlates of broadly neutralizing antibody development against HIV

Mark Kowarsky, Mercedes Dalman, Mira N. Moufarrej, Jennifer Okamoto, Yike Xie, Norma F. Neff, Salim S. Abdool Karim, Nigel Garrett, Penny L. Moore, Joan Camunas-Soler, Stephen R. Quake

PLOS Pathogens: published April 9, 2026 | https://doi.org/10.1371/journal.ppat.1014066

Cytotoxic Vδ2+ T cell subsets expand in response to malaria in human tonsil and spleen organoids

Kathleen D. Press, Florian Bach, Elsa Sola, Kylie Camanag, Nicholas L. Dooley, Anselma Ivanawati, Damian Oyong, Mayimuna Nalubega, Abel Kakuru, Sedrack Matsiko, Felistas Nankya, Kenneth Musinguzi, Annet Nalwoga, Evelyn Nansubuga, John Ategeka, Charles Ebusu, Bakar Odongo, Chloe Kashiwagi, Xuhuai Ji, Molly Miranda, Joselyn Tachiwa-Appiah, Kareena Sandhu, Lilit Kamalyan, Kattria van der Ploeg, Michelle Boyle, Lisa E. Wagar, Mark M. Davis, Prasanna Jagannathan

PLOS Pathogens: published April 10, 2026 | https://doi.org/10.1371/journal.ppat.1013565

Transcriptional signatures of rapid protection from Sudan virus infection by a single dose of a vesicular stomatitis virus-based vaccine

Brianna M. Doratt, Sheridan B. Wagner, Delphine C. Malherbe, Geoffrey Smith, Andrea Marzi, Ilhem Messaoudi

PLOS Pathogens: published April 10, 2026 | https://doi.org/10.1371/journal.ppat.1014143

HSV ICP27 hijacks host splicing factor SRSF3 to regulate pre-mRNA splicing and export for viral gene expression and immune evasion

Shuang Tang, Amita Patel, Kazuyo Takeda, Keith Peden, Philip R. Krause

PLOS Pathogens: published April 10, 2026 | https://doi.org/10.1371/journal.ppat.1014146

Poxvirus A52 protein subverts autophagy flux by blocking autophagosome–lysosome fusion to promote viral replication

Kang Niu, Yongxiang Fang, Yining Deng, Ziyue Wang, Shijie Xie, Junda Zhu, Baifen Song, Wenxue Wu, Zhizhong Jing, Chen Peng

PLOS Pathogens: published April 13, 2026 | https://doi.org/10.1371/journal.ppat.1014137

Aerobactin is a key driver of hypervirulent Klebsiella pneumoniae translocation and virulence

Giovanna E. Hernandez, Juan D. Valencia-Bacca, Emma F. Bennett, Md. Maidul Islam, Suhrid Maiti, Noah A. Nutter, Taylor M. Young, David L. Caudell, Alicia Costa-Terryll, Jaden J. Skelly, Edison T. Floyd, Hannah M. Atkins, M. Ammar Zafar

PLOS Pathogens: published April 13, 2026 | https://doi.org/10.1371/journal.ppat.1014122

C/EBP-β-regulated complement hyperactivation in spleen of SFTSV-infected mice: A clue to targeted complement therapy

Yan Liu, Meng Xu, Xihua Huang, Xiaohan Liu, Kai Fan, Yingying Zhang, Chen Xing, Hailin Tang, Jiayue Jiang, Kehan Xu, Maozhang He, Gang Xu, Cong Zhang

PLOS Pathogens: published April 15, 2026 | https://doi.org/10.1371/journal.ppat.1014144

Large-scale phenotyping and comparative genomics reveal genetic features of Listeria persistence in epithelial cells

Aurélie Lotoux, Matthieu Bertrand, Pierre-Emmanuel Douarre, Mounia Kortebi, Hélène Riveiro, Federica Palma, Goran Lakisic, Edward M. Fox, Laurent Guillier, Anna Oevermann, Sophie Roussel, Hélène Bierne, Alessandro Pagliuso, Eliane Milohanic

PLOS Pathogens: published April 15, 2026 | https://doi.org/10.1371/journal.ppat.1013323

Regional Lassa virus lineages select for divergent MHC-I repertoires in Mastomys natalensis rodents

Ayodeji Olayemi, Jan Sarapak, Kerstin Wilhelm, Stephan Günther, Simone Sommer, Elisabeth Fichet-Calvet, Dominik Werner Melville

PLOS Pathogens: published April 17, 2026 | https://doi.org/10.1371/journal.ppat.1014121

Japanese encephalitis virus orchestrates GLUT4-mediated glucose metabolism to potentiate viral replication via insulin receptor signaling

Qi Wang, Ping Hao, Sheng-yan Zhu, Jiang-fei Zhou, Sheng Feng, Qi Dai, Jian-chao Wei, Yun Young Go, Jing Chen, Bin Zhou

PLOS Pathogens: published April 17, 2026 | https://doi.org/10.1371/journal.ppat.1014164

Genetic complementation reveals structure-function links in nodavirus RNA replication complex crowns

Johan A. den Boon, Helena Jaramillo-Mesa, Mark Horswill, Adam Jochem, Megan Bracken, Hong Zhan, Paul Ahlquist

PLOS Pathogens: published April 20, 2026 | https://doi.org/10.1371/journal.ppat.1013802

Limited protection against early-life lung murine cytomegalovirus infection results from deficiency of cytotoxic CD8 T cells

Luís Fonseca Brito, Eleonore Ostermann, Silvia Tödter, Sanamjeet Virdi, Daniela Indenbirken, Renke Brixel, Ramon Arens, Adam Grundhoff, Wolfram Brune, Felix Rolf Stahl

PLOS Pathogens: published April 20, 2026 | https://doi.org/10.1371/journal.ppat.1014150

Cadherin-11 serves as a novel receptor for Fusobacterium nucleatum adhesin FadA to exacerbate pulmonary inflammation

Kun Liu, Xinyun Xie, Yuchao Li, Shuwei Zhang, Wenli Zang, Qian Li, Yaping Pan

PLOS Pathogens: published April 20, 2026 | https://doi.org/10.1371/journal.ppat.1014158

Combining pangenomics and population genetics finds chromosomal re-arrangements, diversified chromosome segments, copy number variations and transposon polymorphisms in wheat and rye powdery mildew

Alexandros G. Sotiropoulos, Marion C. Müller, Lukas Kunz, Johannes P. Graf, Levente Kiss, Ralph Hückelhoven, Edith Schlagenhauf, Beat Keller, Thomas Wicker

PLOS Pathogens: published April 20, 2026 | https://doi.org/10.1371/journal.ppat.1013196

Entry, replication and innate immunity evasion of BANAL-236, a SARS-CoV-2-related bat virus, in Rhinolophus and human cells

Ségolène Gracias, Elodie Le Seac’h, Samuel Donaire-Carpio, Françoise Vuillier, Léa Vendramini, Adam Moundib, Sarah Temmam, Magdalena Rutkowska, Flora Donati, Anastasija Cupic, Javier Juste, Carles Martinez-Romero, Nathalie Morel, Olivier Schwartz, Nevan J. Krogan, Lisa Miorin, Marcel A. Müller, Caroline Demeret, Sandie Munier, Philippe Roingeard, Jyoti Batra, Adolfo Garcia-Sastre, Vincent Caval, Nolwenn Jouvenet

PLOS Pathogens: published April 20, 2026 | https://doi.org/10.1371/journal.ppat.1013573

Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex

Stefano Sellitto, Davide Caredio, Matteo Bimbati, Giovanni Mariutti, Martina Cerisoli, Lukas Frick, Vangelis Bouris, Carlos Omar Oueslati Morales, Dalila Laura Vena, Sandesh Neupane, Federico Baroni, Kathi Ging, Jiang-An Yin, Elena De Cecco, Andrea Armani, Adriano Aguzzi

PLOS Pathogens: published April 20, 2026 | https://doi.org/10.1371/journal.ppat.1014056

Outdoor roaming of owned cats elevates risk of zoonotic pathogen exposure: A global synthesis

Amy G. Wilson, Scott Wilson, Peter P. Marra, David R. Lapen

PLOS Pathogens: published April 20, 2026 | https://doi.org/10.1371/journal.ppat.1014160

Quantifying the role of pre-existing tissue resident cellular immunity in limiting respiratory virus transmission

Ananya Saha, Sarah E. Michalets, Ida Uddbäck, Hasan Ahmed, Jacob E. Kohlmeier, Rustom Antia, Katia Koelle

PLOS Pathogens: published April 21, 2026 | https://doi.org/10.1371/journal.ppat.1014082

Broadly conserved protective epitopes on the lyme disease vaccine antigen, OspA

Graham G. Willsey, Michael J. Rudolph, Carol Lyn Piazza, Yang Chen, Grace Freeman-Gallant, Lisa A. Cavacini, David J. Vance, Nicholas J. Mantis

PLOS Pathogens: published April 21, 2026 | https://doi.org/10.1371/journal.ppat.1013740

Live attenuated vaccination protects aged chimeric ACE2 mice from severe SARS-CoV-2 pathogenicity in vivo

Alina Russ, Vera Viherlehto, Stefanie Brey, Sabine Wittmann, Pascal Irrgang, Natascha Leicht, Arne Cordsmeier, Armin Ensser, Ralf J. Rieker, Carol Geppert, Heinrich Sticht, Matthias Tenbusch, Thomas H. Winkler, Thomas Gramberg

PLOS Pathogens: published April 22, 2026 | https://doi.org/10.1371/journal.ppat.1014167

Physiologic recovery of Mycobacterium tuberculosis from drug injury: A molecular study of post antibiotic effect in vitro and in vivo

Jo Hendrix, Reem Al Mubarak, Matthew J. Reichlen, Samuel T. Tabor, Adeline Bateman, Lisa M. Massoudi, Karen Rossmassler, Firat Kaya, Matthew D. Zimmerman, Holly Nielsen, Elizabeth A. Wynn, Martin I. Voskuil, Gregory T. Robertson, Camille M. Moore, Nicholas D. Walter

PLOS Pathogens: published April 22, 2026 | https://doi.org/10.1371/journal.ppat.1014131

Nicotinamide metabolism is essential for Hepatitis C Virus replication and the production of infectious Lipo-Viro-Particles

Johan Toesca, Marion Castell, Clémence Jacquemin, Alexandre Lalande, Eva Ogire, Julien Burlaud-Gaillard, Philippe Roingeard, Christophe Ramière, Cyrille Mathieu, Laure Perrin-Cocon, Vincent Lotteau, Pierre-Olivier Vidalain, Olivier Diaz

PLOS Pathogens: published April 22, 2026 | https://doi.org/10.1371/journal.ppat.1014165

Modeling neonatal immune response to B. pertussis identifies early B cell activation and differentiation

Soraya Matczak, Mirko Sadi, Pauline Leroux, Pauline Labé, Valérie Bouchez, Sandrine Schmutz, Valentina Libri, Valérie Seffer, Sophie Novault, Stevenn Volant, Sylvain Brisse, Milena Hasan, Darragh Duffy, Pierre Tonnerre, Julie Toubiana

PLOS Pathogens: published April 22, 2026 | https://doi.org/10.1371/journal.ppat.1014163

Contemporary HIV-1 envelope pseudovirus panels for detecting and assessing B cell lineages with broadly neutralizing antibody potential

Bette Korber, Michael S. Seaman, Nonhlanhla N. Mkhize, Kelli Greene, Hongmei Gao, Xiaoying Shen, Elizabeth Domin, Haili Tang, James Theiler, Kshitij Wagh, Penny L. Moore, Carolyn Williamson, James I. Mullins, Nicole A. Doria-Rose, David Montefiori, Elena E. Giorgi

PLOS Pathogens: published April 23, 2026 | https://doi.org/10.1371/journal.ppat.1013739

MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway

Hongqi Shang, Shanshan Yang, Min Sun, Yongxiang Zhao, Rongli Guo, Wei Wang, Bingxu Qian, Yunchuan Li, Mi Hu, Xianyu Bian, Qiuxia Cao, Chengcheng Li, Baochao Fan, Bin Li

PLOS Pathogens: published April 24, 2026 | https://doi.org/10.1371/journal.ppat.1014170

Prion shedding is reduced by chronic wasting disease vaccination

Hanaa Ahmed-Hassan, Dalia Abdelaziz, Yo-Ching Cheng, Kevin Low, Shirley Phan, Byron Kruger, Chimoné S. Dalton, Lech Kaczmarczyk, Walker S. Jackson, Sabine Gilch, Hermann M. Schätzl

PLOS Pathogens: published April 24, 2026 | https://doi.org/10.1371/journal.ppat.1014166

Duck plague virus LORF2 utilizes RNF34 to inhibit antiviral innate immunity by ubiquitination and degradation of IRF7

Yanming Tian, Bin Tian, Ran Ran, Dongjie Cai, Zhen Xiao, Mingshu Wang, Ying Wu, Qiao Yang, Shaqiu Zhang, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Di Sun, Juan Huang, Xumin Ou, Zhen Wu, Yu He, Renyong Jia, Shun Chen, Anchun Cheng

PLOS Pathogens: published April 24, 2026 | https://doi.org/10.1371/journal.ppat.1014174

Structural basis for substrate recognition and inhibition of thioredoxin glutathione reductase from Schistosoma japonicum: Implications for antiparasitic development

Songqing Wang, Wenbin Hong, Shukun Zhong, Zhijian Liang, Tianyichen Xiao, Chuchu Zhang, Xianshu Liu, Ziyi Dai, Yunlong Li, Siqi Wu, Qixu Cai, Caiming Wu, Yuxuan Huang, Peicheng Hong, Haixia Ren, Shaowei Li, Tianwei Lin, Xueqin Chen, Shuaiqin Huang

PLOS Pathogens: published April 24, 2026 | https://doi.org/10.1371/journal.ppat.1014125

Pre-Human Immunodeficiency Virus (HIV) infection Th17 CD4⁺ T cells as predictors of early HIV disease progression

Tosin E. Omole, Huong Mai Nguyen, Agata Marcinow, Naima Jahan, Giulia Severini, Nivashnee Naicker, Katherine Thomas, Connie Celum, Nelly Mugo, Andrew Mujugira, James Kublin, Lawrence Corey, Aida Sivro, Jairam Lingappa, Glenda Gray, Lyle R. McKinnon

PLOS Pathogens: published April 24, 2026 | https://doi.org/10.1371/journal.ppat.1013852

Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages

Madhura Kulkarni, Christopher M. Bourne, Ashutosh B. Mahale, Patrick M. Exconde, Cecelia Murphy, Haley T. Goodrow, Sofia Cervantes, Matilda Kardhashi, Mirai Kambayashi, William Yoo, Tristan J. Wrong, Robert C. Patio, Bohdana M. Discher, Cornelius Y. Taabazuing

PLOS Pathogens: published April 27, 2026 | https://doi.org/10.1371/journal.ppat.1014178

Single-cell profiling reveals that dynamic lung immune responses distinguish protection from susceptibility to tuberculosis

Fergal J. Duffy, Maxwell L. Neal, Courtney R. Plumlee, Sara B. Cohen, Benjamin H. Gern, Alan H. Diercks, Michael Y. Gerner, Kevin B. Urdahl, John D. Aitchison

PLOS Pathogens: published April 27, 2026 | https://doi.org/10.1371/journal.ppat.1013635

Seasonal forcing and waning immunity drive the sub-annual periodicity of the COVID-19 epidemic

Ilan N. Rubin, Mary Bushman, Marc Lipsitch, William P. Hanage

PLOS Pathogens: published April 27, 2026 | https://doi.org/10.1371/journal.ppat.1014169

Detailed single-cell mapping of the transcriptional response to a virus infection driven by copy-back viral genomes

Yanling Yang, Emna Achouri, Munyaradzi Tambo, Carolina B. López

PLOS Pathogens: published April 27, 2026 | https://doi.org/10.1371/journal.ppat.1014184

Identification of a novel fiber shaft structural motif and overexpression of key transcripts elucidated in human adenovirus D 10

Rosie M. Mundy, Kasim Waraich, Emily A. Bates, Pierre J. Rizkallah, Alexander T. Baker, Mark T. Young, Edward Morris, Paula C. A. da Fonseca, Carly M. Bliss, David Matthews, David Bhella, Alan L. Parker

PLOS Pathogens: published April 28, 2026 | https://doi.org/10.1371/journal.ppat.1014182

Cryptic sex in Leishmania depends on SPO11 paralogs

Carolina M. C. Catta-Preta, Vitor Luiz da Silva, Claudio Meneses, Kashinath Ghosh, David L. Sacks

PLOS Pathogens: published April 29, 2026 | https://doi.org/10.1371/journal.ppat.1014181

BRD4 modulates antimicrobial defense via non-canonical NRF2 activation in macrophages to confer protection against sepsis

Jinfeng Hu, Xuming Gao, Guo Li, Xiaoxin He, Yanting Ke, Zhongheng Zhang, Duozhi Pang, Zhen Lin, Cailian Xie, Xiaoting Chen, Minting Jiang, Shuping Zheng, Suhong Yu, Mingrui Lin, Dun Pan, Xiaopei Shen, Xiangming Hu

PLOS Pathogens: published April 30, 2026 | https://doi.org/10.1371/journal.ppat.1014192

Reorganizing the RNA polymerase II complex for replication of an infectious noncoding RNA in vivo

Jie Hao, Zhuan Qin, Junfei Ma, Jie Qu, Yunhan Wang, Svetlana Y. Folimonova, Bin Liu, Wenwei Li, Ying Wang

PLOS Pathogens: published April 30, 2026 | https://doi.org/10.1371/journal.ppat.1014200

The AltR transcription factor responds to plant thiosulfinates to regulate gene expression in a bacterial pathogen of onion

Hsiao-Hsuan Jan, Feng Kong, Michelle P. MacLellan, Li Yang, Bhabesh Dutta, Brian H. Kvitko

PLOS Pathogens: published April 30, 2026 | https://doi.org/10.1371/journal.ppat.1014198

Correction: Temporal gating of nuclear import: How Merkel cell polyomavirus exploits the cell cycle for nuclear entry

Karen Wang, Adrienne N. Eady, Isabel Amaya, Alina Stanczak, Chelsey C. Spriggs

PLOS Pathogens: published April 2, 2026 | https://doi.org/10.1371/journal.ppat.1014095

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Correction: Origin, evolution, and success of pbla, the gonococcal beta-lactamase plasmid, and implications for public health

Tabea A. Elsener, Ana Cehovin, Connor Philp, Kate Fortney, Stanley M. Spinola, Martin C. J. Maiden, Christoph M. Tang

PLOS Pathogens: published April 14, 2026 | https://doi.org/10.1371/journal.ppat.1014134

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Correction: Effects of Capsular Polysaccharide amount on Pneumococcal-Host interactions

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PLOS Pathogens: published April 16, 2026 | https://doi.org/10.1371/journal.ppat.1014141

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Correction: Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression

Anna Bachmann, Ellen Bruske, Ralf Krumkamp, Louise Turner, J. Stephan Wichers, Michaela Petter, Jana Held, Michael F. Duffy, B. Kim Lee Sim, Stephen L. Hoffman, Peter G. Kremsner, Bertrand Lell, Thomas Lavstsen, Matthias Frank, Benjamin Mordmüller, Egbert Tannich

PLOS Pathogens: published April 28, 2026 | https://doi.org/10.1371/journal.ppat.1014177

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Correction: IL-6 is one of the key factors in the formation of gut tissue resident memory T cells from Naïve T cells

Han G. Kim, Amanda Chan, Sinmanus Vimonpatranon, Alexandre Girard, Andrew Jiang, Samuel Wertz, Il-Young Hwang, John H. Kehrl, Hana Schmeisser, Madelyn M. Seemiller, Paolo Lusso, Dawei Huang, Danlan Wei, Livia R. Goes, Marcelo Soares, Elena Martinelli, James Arthos, Claudia Cicala

PLOS Pathogens: published April 28, 2026 | https://doi.org/10.1371/journal.ppat.1014176

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