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Dive! Dive! Dive!

June 18, 2019

Dive! Dive! Dive!

Chris McKnight, Dave Thompson and colleagues use wearable near-infrared spectroscopy devices in seals to reveal that the mammalian dive response is not a reflexive response to facial immersion or apnoea, but may be under anticipatory cognitive control in voluntarily diving marine mammals.

Image credit: Flickr user Ian Lee

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PLOS Biology's XV Collection

06/17/2019

Research Article

E. coli Flagellin Provides Benefits for the Host

A flagellum renders bacteria motile, but Alex Steimle, Sarah Menz, Julia-Stefanie Frick and co-workers reveal another property important for symbiosis: the hypervariable region of Escherichia coli flagellin strongly determines activation of TLR5, mediating benefits for the host such as protection against colitis.


Image credit: Flickr user NIAID

E. coli Flagellin Provides Benefits for the Host

Recently Published Articles

Current Issue

Current Issue May 2019

06/19/2019

Research Article

A Hexabody for Gonorrhea

Sunita Gulati, Frank Beurskens, Sanjay Ram and colleagues find that a chimeric antibody that contains a "complement-enhancing" mutation in Fc (so-called HexaBody technology) shows increased bactericidal activity compared to antibody bearing wild-type Fc and may represent a promising immunotherapeutic approach against multidrug-resistant gonorrhea.

Image credit: pbio.1002344

A Hexabody for Gonorrhea

06/18/2019

Short Reports

Birds Flap Faster to Flock

Flocking costs may have been underestimated by an order of magnitude: a study of homing pigeons by Lucy Taylor, Steven Portugal and co-authors shows that they flap 20% faster when flying in pairs relative to flying solo to keep their heads steady and reap the ultimate benefits of flocking.

Image credit: Lucy Taylor

Birds Flap Faster to Flock

06/18/2019

Research Article

Metabolomics of the Night Shift

A study of simulated night shifts in humans by Laura Kervezee, Nicolas Cermakian and Diane Boivin shows that 24-hour rhythms in plasma metabolites are primarily influenced by behavioural cycles rather than the endogenous clock; in addition, a large degree of variability between individuals suggests the existence of individual metabolomic signatures of circadian misalignment.

Metabolomics of the Night Shift

Image credit: Flickr user José

06/17/2019

Research Article

Star Nanoparticles Deliver HIV Vaccine

Joseph Francica, Robert Seder and co-authors find that synthetic polymer-based nanoparticles effectively deliver HIV Env glycopeptide immunogens to lymph nodes and stimulate B cell lineages with characteristics resembling broadly neutralizing antibodies, in nonhuman primates.

Star Nanoparticles Deliver HIV Vaccine

Image credit: pbio.3000328

06/18/2019

Research Article

Neuroinflammation and Tinnitus

Prolonged exposure to loud noises causes neuronal hyperexcitability and increases the risk of tinnitus. Weihua Wang, Shaowen Bao and co-workers reveal that this type of tinnitus is mediated by noise-induced neuroinflammation; blockade of neuroinflammatory responses prevents noise-induced neuronal excitation/inhibition imbalance and tinnitus.

Neuroinflammation and Tinnitus

Image credit: Flickr user Naika Lieva

06/14/2019

Methods and Resources

Herpesvirus Interactome

Consensus clustering of protein-protein interaction networks provides insights into the assembly mechanism of herpes simplex virus type 1 (HSV1) virions and structure-function relationships underlying herpesvirus infection.


Herpesvirus Interactome

Image credit: pbio.3000316

06/19/2019

Research Article

Neutrality in the Metaorganism

A study of microbiome compositions from host species across the tree of life reveals them to be consistent with neutral expectations, suggesting that after colonization, neutral processes and dispersal play a role in shaping communities.

Neutrality in the Metaorganism

Image credit: pbio.3000298

06/18/2019

Research Article

Sugars Mediate Transmission of Parkinson's

Extracellular N-linked glycans (and neurexin 1β) are key modulators of neuronal uptake of N-terminally acetylated α-Synuclein, emphasising the potential therapeutic value of α-Synuclein-glycan interactions.

Sugars Mediate Transmission of Parkinson's

Image credit: pbio.3000318

06/14/2019

Research Article

How Plasmodium Keeps Actin Filaments Short

A detailed mechanistic study of malaria parasite actins reveals at the atomic level how they polymerize, hydrolyze ATP, and are fragmented to keep actin filament lengths short enough for parasite survival.


How Plasmodium Keeps Actin Filaments Short

Image credit: pbio.3000315

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