10/30/2025
Meta-Research Article
Unchallenged erroneous articles can undermine scientific progress and mislead future research. René Aquarius, Kimberley Wever and co-workers reveal that image-related issues affect 40% of reviewed articles on early brain injury in animal studies, yet corrective actions by journals remain limited.
Image credit: pbio.3003438
Current Issue September 2025
10/28/2025
Research Article
Zoonotic influenza A viruses pose a persistent threat, yet the antiviral barriers to cross-species transmission remain unclear. Jordan Becker, Reuben Harris, Ryan Langlois and co-authors find that CpG-enriched avian viruses are restricted by several mammalian proteins, including human ZAP and platypus KHNYN.
Image credit: pbio.3003471
10/28/2025
Research Article
There is increasing interest in developing imaging-based models to characterize 'brain-age', but how accurate are these for predicting neurological disease? Marc-Andre Schulz, Nys Tjade Siegel and Kerstin Ritter show that simpler models, which have lower age prediction accuracy, are paradoxically more sensitive to disease-related brain changes, suggesting the field re-evaluate modeling priorities.
Image credit: pbio.3003451
10/28/2025
Research Article
PRMT5 is a histone methyltransferase upregulated in various cancer types, but its role in regulating alternative splicing events is unknown. Srinivas Abhishek Mutnuru, Sanjeev Shukla and colleagues show that PRMT5 regulates TCF3 alternative splicing under hypoxia and that this promotes EMT and invasion of breast cancer cells.
Image credit: pbio.3003444
10/27/2025
Research Article
Variability in neural activity is associated with cognition, but how this variability relates to pain is poorly understood. Li-Bo Zhang, Xin-Yi Geng and Li Hu find that neural variability correlates with how individuals perceive pain intensity in different contexts, enhancing our understanding of the neural encoding of pain.
Image credit: pbio.3003470
10/27/2025
Research Article
Cytokinesis relies on coordinated contractile-ring constriction, vesicle trafficking, and extracellular matrix remodeling. Sha Zhang, Davinder Singh, Jian-Qiu Wu and co-workers show that the Ync13-Rga7-Rng10 module coordinates tethering and fusion of vesicles containing glucan synthases at the division site in fission yeast, ensuring proper septum formation and cell integrity during cytokinesis.
Image credit: pbio.3003466
10/30/2025
Perspective
Incomplete characterization and inconsistent reporting of lab animal genetics undermine research reproducibility. This Perspective highlights the LAG-R guidelines and calls for collective action to enhance scientific integrity.
Image credit: Lydia Teboul
10/22/2025
Essay
Mitochondrial dynamics are important regulators of various cancer cell phenotypes. This Essay discusses the role of mitochondrial dynamic regulators in tumor growth and metastasis and explores how they can be targeted therapeutically.
Image credit: pbio.3003453
10/21/2025
Community Page
Science projects are designed and funded on the scale of years, so what happens when you need to finish prematurely? This Community Page discusses solutions for finalizing partially finished projects.
Image credit: Unsplash user Mantas Hesthaven
10/21/2025
Essay
Disease-associated microglia are a distinct, conserved microglial state. This Essay discusses the dynamics, origins and therapeutic potential of these microglia in neurodegeneration.
Image credit: pbio.3003426
Recent technological advancements in omics have unveiled the mechanisms governing tumor progression across spatial and temporal scales. This collection reveals the complexities of the crosstalk between cancer cells and the tumor microenvironment.
Neurotechnology offers unprecedented opportunities to treat neural disorders, restore brain function and enhance cognitive abilities. This collection explores the present and possible futures of neurotechnology to improve human health and cognition.
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
.
November 11 - 14
Meet Senior Editor Richard Hodge (rhodge@plos.org)
November 15 - 19
Meet Associate Editor Taylor Hart (thart@plos.org)
November 25 - 27
Meet Senior Editor Roland Roberts (rroberts@plos.org)
December 15 - 16
Meet Editor in Chief Nonia Pariente (npariente@plos.org)
Connect with Us