Insulin-Like Peptide Matches Weapon Size to the Beetle

G protein-coupled receptors (GPCRs) are the most commonly used family of drug targets in most disease settings other than cancer. Krishna Sriram, Paul Insel and co-authors reveal that GPCRs (including many which are already targets of approved drugs) show elevated expression in solid tumors. Expression of certain GPCRs appears to have prognostic relevance, and many GPCRs undergo widespread mutation and copy number variation.

Pedro Tiago Martins and Cedric Boeckx argue that the evolution of language cannot be as simple as prominent linguists Berwick and Chomsky have recently proposed, showing that the jump from the atomicity of Merge to a single-mutation scenario is not valid, and therefore cannot be used as justification for theory of language evolution along those lines. Also read the response by Robert Berwick and Noam Chomsky.

Why do individuals within populations vary enormously in mortality risk and longevity? A study of neriid flies by Zachariah Wylde, Russell Bonduriansky and co-workers shows that paternal age can affect offspring longevity as strongly as maternal age does, and that breeding age effects can interact over two generations in both matrilines and patrilines.