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Propelling the Lyme Disease Pathogen

November 9, 2018

Propelling the Lyme Disease Pathogen

Cryo-electron tomography of periplasmic flagella in the Lyme disease bacterium Borrelia burgdorferi, by Zhuan Qin, Jiagang Tu, Md Motaleb, Jun Liu and colleagues reveals a distinct cytoplasmic ATPase complex and an atypical interaction with the flagellar C-ring.

Image credit: pbio.3000050

Celebrate our 15th Anniversary! Tweet @PLOSBiology #PLOSBIO15

PLOS Biology's XV Collection

11/08/2018

methods and resources

Sleeping or Just Pretending?

Sophie Bagur, Karim Benchenane and co-authors show that gamma oscillations in the olfactory bulb track changes in vigilance states with remarkable precision, allowing the development of a novel fully brain-based sleep-scoring methodology and real-time monitoring of depth of anaesthesia.

Image credit: pbio.2005458

Sleeping or Just Pretending?

Recently Published Articles

Current Issue

Current Issue October 2018

11/08/2018

RESEARCH ARTICLE

TRIM59, PDCD10 and Breast Cancer Metastasis

Bioinformatic analysis and experiments on clinical samples and mouse models of breast cancer, by Peng Tan, Leng Han, Weidong Han, Yubin Zhou and colleagues, unveil a new signaling protein degradation pathway involving TRIM59 and PDCD10 that modulates breast cancer cell growth, survival, and metastasis.

Image credit: pbio.3000051

TRIM59, PDCD10 and Breast Cancer Metastasis

11/02/2018

SHORT REPORT

Pyroptosis and Neonatal-Onset Multisystem Inflammatory Disease

Jianqiu Xiao, Chun Wang, Gabriel Mbalaviele and co-authors show that pyroptosis mediated by the pore-forming protein gasdermin D plays a crucial role in the pathogenesis of neonatal-onset multisystem inflammatory disease (NOMID), a severe genetic autoinflammatory disorder resulting from activating mutations in the NLRP3/cryopyrin gene.

Image credit: pbio.3000047

Pyroptosis and Neonatal-Onset Multisystem Inflammatory Disease

11/07/2018

PRIMER

EBP1: Downstream of Receptor Kinases Everywhere

Martin Stegmann discusses the recent demonstration that EBP1 is a major transcriptional and translational regulator across kingdoms, acting downstream of EGFR signalling in animals and the central receptor kinase FERONIA in plants. Read the related Research Article.

EBP1: Downstream of Receptor Kinases Everywhere

Image credit: pbio.2006340

11/01/2018

Research Article

How Leaves Grow

Samantha Fox, Paul Southam, Florent Pantin, Enrico Coen and colleagues use a combination of computational modelling and live imaging to show how leaves form through dual spatiotemporal control of growth and cell division, with cross-connections between them.

How Leaves Grow

Image credit: pbio.2005952

10/31/2018

SHORT REPORT

EGFR, Patterning and Survival

Cells lacking essential patterning determinants are eliminated from developing tissues by apoptosis; Samuel Crossman, Sebastian Streichan and Jean-Paul Vincent show that cell death in fruit fly segmentation mutants results from disruption of the pattern of EGFR signalling, which in normal embryos coordinates segment size with patterning information.

EGFR, Patterning and Survival

Image credit: pbio.3000027

10/31/2018

Research Article

IL-4Rα Holds Inflammation at Bay

Foxp3+ regulatory T cells require an intact IL-4Rα-mediated signaling pathway to efficiently contain immune responses and control tissue inflammation during helminth infection.

IL-4Rα Holds Inflammation at Bay

Image credit: pbio.2005850

10/30/2018

Research Article

Tolerating Transposable Elements

The first example of natural variation in tolerance of transposable elements, whereby host cells modulate the deleterious effects without regulating transposition. Read the accompanying Primer.

Tolerating Transposable Elements

Image credit: pbio.2006040

10/26/2018

research article

How Bats Measure Microseconds

Sound-evoked extracellular field potential recordings and mathematical modeling reveal a neural code for the extraordinarily precise (microsecond) registration of the timing of acoustic events in echolocating bats. 

How Bats Measure Microseconds

Image credit: pbio.2006422

11/08/2018

Channel 

Responding to Climate Change

The PLOS Responding to Climate Change Channel highlights research efforts from a range of disciplines focussed on understanding, evaluating, predicting, mitigating, and adapting to the causes and effects of the changing climate.

Responding to Climate Change

Image credit: Victor Benard, Unsplash

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