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Mendel’s legacy in modern genetics

July 28, 2022

Mendel’s legacy in modern genetics

To celebrate the bicentenary of Gregor Mendel’s birth, PLOS Biology presents a special Collection of articles that discuss his life, work and legacy in modern-day genetic research. Read Joanna Clarke's accompanying Editorial.


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PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

07/28/2022

Research Article

Plasmodium's kinesin toolkit

Mohammad Zeeshan, Rita Tewari and colleagues reveal that kinesins in the malaria parasite Plasmodium have diverse cellular roles and locations, including functions in spindle assembly during proliferation, axoneme formation in flagellum biogenesis, and determining the apical morphology of the cell.

Image credit: pbio.3001704

Plasmodium's kinesin toolkit

Recently Published Articles

Current Issue

Current Issue June 2022

07/28/2022

Short Reports

Encoding voice features

Voice perception occurs via specialized networks in higher order auditory cortex, but how voice features are encoded remains a central unanswered question. Using human intracerebral recordings of auditory cortex, Kyle Rupp, Taylor Abel and co-workers provide evidence for categorical encoding of voice. Also read the accompanying Primer by Benjamin Morillon, Luc Arnal and Pascal Belin.

Image credit: pbio.3001742

Encoding voice features

07/27/2022

Research Article

Coronaviruses poised for zoonosis?

Knowing which viruses are primed for zoonotic transmission can focus surveillance efforts and mitigation strategies for future pandemics. Sarah Roelle, Kenneth Matreyek and co-authors show that SARS-like coronaviruses identified in bats from Europe and Africa can use a range of horseshoe bat ACE2s for entry. In addition, viruses found in Russia and Kenya also have the ability to at least weakly use human ACE2.

Image credit: pbio.3001738

Coronaviruses poised for zoonosis?

07/26/2022

Essay

Crop biotechnology for climate resilience

Will gene editing contribute to improved crop diversity and climate resilience? In this Essay, Sarah Garland and Helen Curry look at lessons from past biotechnology efforts to inform action for the future.

Crop biotechnology for climate resilience

Image credit: pbio.3001716

07/25/2022

Methods and Resources

Measuring plasmid transfer rates

Plasmid transfer can often spread resistance between important clinical pathogens. Olivia Kosterlitz, Benjamin Kerr and colleagues show that widely used methods can lead to biased estimates of plasmid transfer rate by several orders of magnitude, and present a new approach, inspired by the classic Luria-Delbrück approach, for accurately assessing this fundamental rate parameter.

Measuring plasmid transfer rates

Image credit: pbio.3001732

07/25/2022

Research Article

How sickness affects taste

Sickness is an internal state that impacts consumption, and so could be expected to influence the neural processing of tastes. Bradly Stone, Donald Katz and co-workers show that onset of illness changes basic properties of gustatory cortical network processing and taste responses, such that activity comes more purely to reflect the "goodness" or "badness" of tastes.

How sickness affects taste

Image credit: pbio.3001537

07/21/2022

Unsolved Mystery

What happened to anti-amyloid therapies?

Evidence suggests that an imbalance between production and clearance of amyloid-beta is an early, invariant feature of Alzheimer's disease. This article asks why we are still unable to slow cognitive decline with anti-amyloid therapies.

What happened to anti-amyloid therapies?

Image credit: pbio.3001694

07/20/2022

Primer

Expanding the epitranscriptome

This Primer explores two new studies, one in PLOS Biology, showing that ~130 yeast mRNAs contain dihydrouridine, a derivative of uridine. Functional studies show that dihydrouridine, in some cases, can affect mRNA splicing.

Expanding the epitranscriptome

Image credit: pbio.3001720

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PLOS Biology | ISSN: 1545-7885 (online)