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Polarization of the human intestinal epithelium

December 2, 2024

Polarization of the human intestinal epithelium

The intestinal epithelium is a polarized monolayer of cells and both proteins and mRNAs have been shown to have global basal-apical polarization in mice. Roy Novoselsky, Shalev Itzkovitz and colleagues perform a systematic analysis of human intestinal cells and show that while mRNAs have similar polarization patterns than in mice, mitochondria and ribosomes are less polarized in humans.

Image credit: Roy Novoselsky

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

12/03/2024

Research Article

Distinct components of sensorimotor learning

What are the neural correlates of the multiple competing processes that occur simultaneously during sensorimotor learning? Corson Areshenkoff, Jason Gallivan and co-workers reveal three distinct neural connectivity patterns within the motor cortex that are associated with implicit learning, explicit learning and the tracking of performance.

Image credit: pbio.3002934

Distinct components of sensorimotor learning

Recently Published Articles

Current Issue

Current Issue November 2024

12/03/2024

Research Article

How fast do viruses spread in the wild?

How fast are viruses spreading in the wild? Simon Dellicour, Philippe Lemey and co-authors evaluate the performance of dispersal metrics estimated using phylogeographic analysis of genomic data from viral epidemics. Comparison with the dispersal capacity of a broad range of viruses spreading in animal populations highlights important differences that can be related to host and/or human-mediated movements.

Image credit: pbio.3002914

How fast do viruses spread in the wild?

12/03/2024

Methods and Resources

Hyperspectral imaging for animal coloration research

Animal coloration research has flourished recently but the uptake of hyperspectral imaging methods has been slow. Benedict Hogan and Mary Caswell Stoddard develop a user-friendly pipeline for hyperspectral imaging and highlight its advantages in measuring animal coloration by comparing two birds-of-paradise and their rare hybrid offspring.

Image credit: David Ocampo

Hyperspectral imaging for animal coloration research

12/02/2024

Research Article

MC1R, melanogenesis and the BBSome

Melanin production in the skin protects us against UV damage, but how? Xiaoyu Tian, Hanyu Wang, Song Liu, Rutao Cui, Jun Zhou and colleagues show that upon UV exposure MC1R enters primary cilia and interacts with the BBSome, triggering the downstream signalling that stimulates melanogenesis. Red-haired people have a genetic variation in MC1R that affects this interaction, leading to defective melanin production.

MC1R, melanogenesis and the BBSome

Image credit: pbio.3002940

12/02/2024

Research Article

The thalamus and cognitive control

The cortico-striatal-thalamic circuit is involved in updating cortical task representations, but the role of the thalamus in the context of cognitive flexibility is not well known. Xitong Chen, Kai Hwang and co-authors show that the human thalamus, along with its associated thalamocortical interactions, encodes and updates context representations during hierarchical cognitive control.

The thalamus and cognitive control

Image credit: pbio.3002937

12/02/2024

Research Article

Temperature regulation of sleep

How does temperature affect sleeping patterns? Xin Yuan, Hailiang Li and Fang Guo elucidate the neural circuits in flies that integrate temperature cues with circadian networks to modulate sleep-wake patterns.

Temperature regulation of sleep

Image credit: pbio.3002918

12/03/2024

Perspective

Controlling minor outbreaks is essential

Adam Kucharski argues that successful pandemic preparedness requires early outbreak management, including effective responses that target spillovers before evidence of human-to-human transmission exists.

Controlling minor outbreaks is essential

Image credit: pbio.3002916

11/26/2024

Perspective

Mining biology for antibiotics

The rise of antibiotic resistance calls for innovative solutions. This Perspective outlines how biology can be mined digitally using artificial intelligence as a new paradigm for antibiotic discovery, offering hope in the fight against superbugs.

Mining biology for antibiotics

Image credit: pbio.3002946

11/25/2024

Consensus View

Looking for LECA

Understanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. This Consensus View lays out guidelines to identify the gene repertoire of the Last Eukaryotic Common Ancestor (LECA).

Looking for LECA

Image credit: pbio.3002917

11/22/2024

Perspective

Time to study paper mills

This Perspective, written by members of the United2Act Research Working Group, proposes five key research questions on paper mills that require resourcing and support.

Time to study paper mills

Image credit: Johann Bernhard Basedow via Wikimedia Commons

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