06/18/2021
research article
Anna Heffron, Irene Ong and co-workers use profiling of antibody binding from naïve and COVID-19 convalescent human sera to the entire proteome of SARS-CoV-2 (and other human, bat and pangolin coronaviruses) to identify 79 B cell epitopes throughout the SARS-CoV-2 proteome, finding that the most sensitive and specific binding occurred in the membrane (M) protein, and revealing cross-reactivity patterns.
Image credit: pbio.3001265
Current Issue May 2021
06/17/2021
ESSAY
COVID-19 testing programs are very important to help control the pandemic. James Nichols, Tiffany Bogich, Katriona Shea and co-authors show that objective-driven, strategic sampling designs and analytics can be used to maximize the information gained by COVID-19 testing programs and improve population-level decisions, while maintaining the value of these programs for patient-level management.
Image credit: pbio.3001307
06/17/2021
Methods and Resources
A comprehensive glycoproteomic analysis of Haloferax volcanii, by Stefan Schulze, Mechthild Pohlschroder ad colleagues, reveals the extent and complexity of glycosylation in archaea and provides new insights into the roles of this post-translational modification in various cellular processes, including cell shape determination.
Image credit: pbio.3001277
06/17/2021
Research Article
Yuko Ulrich, Mari Kawakatsu, Corina Tarnita, Daniel Kronauer and co-workers use automated tracking of clonal raider ants and mathematical modeling to reveal how traits of larvae and workers shape social organization in heterogeneous ant colonies. Incorporating the potential for variability in adult task efficiency and larval task demand allow the authors to account for all empirically observed phenomena.
Image credit: Daniel Kronauer
06/16/2021
research article
Pilar Montes-Lourido, Manaswini Kar, Stephen David and Srivatsun Sadagopan study the neuronal representations elicited in guinea pigs by conspecific calls at different auditory processing stages, revealing insights into where call-selective neuronal responses emerge; the transformation from nonselective to call-selective responses occurs in the superficial layers of the primary auditory cortex.
Image credit: pbio.3001299
06/15/2021
Essay
Sarah Davies, Hollie Putnam, Amanda Bates and co-authors argue that success and impact metrics in science are based on a system that perpetuates sexist and racist ‘rewards’ by prioritizing citations and impact factors; the authors advocate shifting this outdated value system to advance science through principles of justice, equity, diversity, and inclusion.
Image credit: pbio.3001282
06/15/2021
Meta-Research Article
When scientists neglect to say that research findings were obtained using mice, the media tend to replicate the trend by omitting the use of mice from news headlines that report on these papers, thereby perpetuating the omission.
Image credit: Sibya (Pixabay), Elnur (iStock) & rez2graphics (Fiverr)
06/14/2021
Research Article
A combined neuroimaging and brain stimulation study reveals rapid and distributed microstructural plasticity after a single language learning session, demonstrating the causal relevance of the motor cortex in encoding the meaning of novel action words.
Image credit: pbio.3001290
06/10/2021
Research Article
LncRNA-PM activates transcription of the cerebellar synaptic organizer Cbln1 by promoting Pax6-Mll1-mediated H3K4me3 methylation, thereby helping to maintain cerebellar synaptic integrity and motor function.
Image credit: Yan Jin, Bowen Zhang & Xiangting Wang
06/10/2021
Research Article
Heart and skeletal muscles of larger mammals contract more slowly than smaller ones. This study identifies amino acid substitutions in human β-myosin that can increase its in vitro velocity to that of the rat protein.
Image credit: pbio.3001248
Raquel Lieberman discusses her work on the protein myocilin, implicated in glaucoma, but whose normal function remains unclear after over 20 years.
Susanna Bidgood explores the future of using poxviruses as versatile tools for cell biology research.
Rachel Harding proposes that open notebooks present an opportunity for researchers to showcase their work and rapidly advance science in their field
On the eve of the UN General Assembly meeting on TB, Christoph Grundner urged the need to consider basic research as an essential component of any future anti-TB strategy.
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
June 21-26
Meet associate editor Luke Smith
June 7-9
Meet senior editor Gabriel Gasque
June 7-8
Meet editor-in-chief Nonia Pariente
June 1-10
Meet editor-in-chief Nonia Pariente
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