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Chemical dialogue between bacterial pathogens

June 21, 2022

Chemical dialogue between bacterial pathogens

Tiffany Zarrella and Anupama Khare use an unbiased genome-scale approach to reveal multiple Staphylococcus aureus secreted factors that are sensed by co-infecting pathogen Pseudomonas aeruginosa.


Image credit: Erina He

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

06/23/2022

Short Reports

The history of snake fungal disease

Snake fungal disease is emerging in eastern North America, but its origins have been unclear. Jason Ladner, Jeffrey Lorch and colleagues use population genetic data to show that the fungus that causes the disease was introduced multiple times to North America over the last few hundred years.

Image credit: pbio.3001676

The history of snake fungal disease

Recently Published Articles

06/22/2022

Methods and Resources

Database of transmission trees to explore superspreaders

Juliana Taube, Paige Miller and John Drake compile and standardize reported infectious disease transmission trees to analyze trends in superspreader frequency and generation; these data support theories that intermediate dispersion parameters favor superspreading events, and that superspreaders generate other superspreaders.

Image credit: pbio.3001685

Database of transmission trees to explore superspreaders

06/21/2022

Research Article

Out of breath?

Response to acute oxygen shortages is indispensable to aerobic life, but its molecular mechanisms are poorly understood. Lina Zhao, Lorenz Fenk, Lars Nilsson, Mario de Bono, Changchun Chen and colleagues reveal that high levels of cGMP and reactive oxygen species (ROS) prevent the nematode Caenorhabditis elegans from escaping hypoxia.

Image credit: pbio.3001684

Out of breath?

06/16/2022

Perspective

The importance of tropical research

Tropical biology is currently largely absent from undergraduate curricula. Ann Russell and co-authors argue that the integration of authentic research in tropical biology could promote internationality among scientists and provide experiential learning that enables students to address complex global problems.

The importance of tropical research

Image credit: J. Leighton Reid

06/16/2022

Research Article

Photoreceptors’ essential inner scaffold

Olivier Mercey, Paul Guichard, Virginie Hamel and colleagues use ultrastructure expansion microscopy on mouse retina to reveal the presence of a novel structure inside the photoreceptor connecting cilium that protects the outer segment against degeneration. See also the related Primer.


Photoreceptors’ essential inner scaffold

Image credit: Olivier Mercey

06/14/2022

Research Article

Gamma oscillations and stimulus discontinuities

Gamma oscillations in visual cortex have been proposed to play an important role in feature binding, but this role has recently been questioned. Vinay Shirhatti, Poojya Ravishankar and Supratim Ray show that visual stimulus-induced gamma oscillations are highly attenuated with even small discontinuities in the stimulus. See also the related Primer.

Gamma oscillations and stimulus discontinuities

Image credit: pbio.3001666

06/14/2022

Research Article

How does valproic acid cause birth defects?

Valproic acid induces cellular senescence in neuroepithelial cells and blocks their differentiation, suggesting that aberrant senescence in the embryo may contribute to postnatal cognitive defects.

How does valproic acid cause birth defects?

Image credit: pbio.3001664

06/13/2022

Short Reports

Single neuron type determines attraction versus aversion

Context-dependent engagement of distinct intracellular signaling pathways within a single sensory neuron type is sufficient to switch response to an odorant from attraction to aversion.

Single neuron type determines attraction versus aversion

Image credit: pbio.3001677

06/10/2022

Research Article

The polyol pathway senses glucose uptake

The polyol pathway is involved in glucose-responsive activation of Mondo/ChREBP-mediated metabolic remodeling in both mice and flies.

The polyol pathway senses glucose uptake

Image credit: Hiroko Sano

06/10/2022

Essay

Does brain activity cause consciousness?

Assuming technology advanced enough to fully manipulate our brains, this thought experiment addresses the question of whether action potentials cause consciousness.

Does brain activity cause consciousness?

Image credit: pbio.3001651

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PLOS Biology | ISSN: 1545-7885 (online)