10/19/2018
research article
A developmental study in the fruit fly Drosophila melanogaster by Jia Chen, Aram-Christopher Sayadian, Nick Lowe, Holly Lovegrove and Daniel St Johnston shows that apical-basal polarity in the midgut epithelium is established by a different mechanism from other Drosophila epithelia, but more akin to that of vertebrate epithelia.
Image credit: pbio.3000041
Current Issue September 2018
10/18/2018
Research Article
Guang-Zhi Jin, Yajuan Zhang, Wen-Ming Cong, Guanzhen Yu, Weiwei Yang and colleagues find that the enzyme phosphoglucomutase 1 acts as a metabolic tumor suppressor that inhibits the progression of hepatocellular carcinoma by switching glycolysis to glycogen synthesis.
Image credit: RCSB PDB
10/18/2018
Short Reports
Can oxygen delivery be directed to severely hypoxic tissues? Jason Boehme, Natacha Le Moan, Ana Krtolica, Emin Maltepe and co-authors show that an engineered hemoprotein with a high oxygen affinity can oxygenate failing sheep hearts without altering global oxygen exposure or triggering systemic toxicity.
Image credit: Jonathan A. Winger
10/18/2018
Methods and Resources
Christine Häger, Lydia Keubler, André Bleich and co-workers propose the monitoring and clustering of voluntary wheel running as a novel tool to assess severity in laboratory mice, thereby enabling unbiased individual severity grading that contributes to 3R principles.
Image credit: Rene Schwietzke, Flikr
10/17/2018
RESEARCH ARTICLE
Andrew Greenhalgh, Samuel David and colleagues show that in response to a CNS injury, peripheral immune cells infiltrate the lesion site and communicate directly with resident immune cells, suppressing their key functions and aiding recovery.
Image credit: pbio.2005264
10/16/2018
Short Reports
Deirdre McCarthy, Pradeep Bhide and co-workers find that nicotine-induced changes in the methylation of mouse spermatozoal DNA are associated with alterations in behavioral and neurotransmitter phenotypes of multiple generations descending from the nicotine-exposed males
Image credit: Pixabay
10/18/2018
research article
Midfrontal cortex theta oscillations are linked to the detection of Pavlovian conflict, and the exertion of cognitive control to reduce the impact of maladaptive, Pavlovian biases.
Image credit: pbio.2005979
10/15/2018
short report
Electrophysiological recordings from the auditory nerve reveal sharper frequency tuning in humans than in animal models, but more limited phase-locking to the waveform of tones.
Image credit: Flickr user monicasecas
10/15/2018
Research Article
Imaging populations of neurons in the crustacean stomatogastric nervous system reveals that different sensory modalities are represented by a combinatorial code of excitatory and inhibitory responses.
Image credit: pbio.2004527
10/15/2018
editorial
As we celebrate our anniversary, the PLOS Biology editors discuss recent initiatives taken by the journal and look ahead to the next fifteen years.
Image credit: pbio.3000049
On the eve of the UN General Assembly meeting on TB, Christoph Grundner urged the need to consider basic research as an essential component of any future anti-TB strategy.
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
Rodrigo Almeida argues that considering the social context of emerging plant diseases and effective science communication are essential for the management epidemics.
Oswald Schmitz suggests that studying how species produce ecological functions can be like watching jazz musicians improvise as they respond and adapt to one another to create their music.
Meta-research may not be as click-worthy as a meta-pug – a pug dog dressed up in a pug costume – but it is crucial to understanding research, says Lisa Bero in this Research Matters article.
How resistance arises at the cellular level, how it evolves and spreads, and how we can combat it.
How animals combine information from the outside world and from within their own bodies to decide what they should eat.
How the engulfment of a small bacterium by a larger archaeon more than a billion years ago resulted not in death, but in one of the most successful partnerships on earth.
The composition and function of microbiomes are critical for most animals and plants; how do relationships between hosts and microbes evolve over time?
Medics have long recognised the curious power of the placebo. What is known of its biological basis and the complex ethical and practical issues that surround it?
Connect with Us