March 12, 2019
Image credit: Flickr user Katja Schulz & pbio.3000155
03/12/2019
Research Article
A global analysis of human impacts on threatened vertebrates, by James Allan, Oscar Venter and co-authors, shows that they are almost ubiquitous across Earth, and hundreds of species have no refuge from these impacts. The study also identifies hotspots of impacted species richness and coolspots of unimpacted species richness.
Image credit: pbio.3000158
Current Issue February 2019
03/13/2019
Research Article
Sexual reproduction is critical for the evolution of pathogenesis and antifungal resistance in pathogenic fungi; Guobo Guan, Li Tao, Guanghua Huang and co-workers show that the predominantly clonal pathogen Candida albicans undergoes efficient same-sex mating under stressful environments, and that the Hsf1/Hsp90 signaling pathway functions as a major regulator in this process.
Image credit: pbio.2006966
03/12/2019
Research Article
A study of the response of fruit flies to oxidative stress, by Human Riahi, Jamie Kramer, Annette Schenck and colleagues, highlights the importance of energy metabolism in fuelling the coordinated transcriptional response to oxidative stress, and identifies the histone methyltransferase G9a as a key player in these processes.
Image credit: pbio.2006146
03/13/2019
Research Article
Single-cell time-lapse imaging and transcriptomic analysis, by Mingwei Min and Sabrina Spencer, reveal why some human cells proliferate more slowly than the majority of the population, with cellular stress responses triggering entry into a slow-cycling state to promote cellular survival in unpredictable environments.
Image credit: pbio.3000178
03/13/2019
Research Article
Electroencephalography, intracranial recording, and fMRI measurements of the human brain, by Lu Shen, Biao Han, Lihan Chen and Qi Chen, reveal how perceptual inference employs intrinsic brain activity to bias the perception of ambiguous sensory information towards predicted percepts.
Image credit: pbio.3000025
03/11/2019
Research Article
Marcin Łyszkiewicz, Samantha Winter, Natalia Ziętara, Andreas Krueger and co-workers show that expression of microRNA miR-181a/b-1 in the thymus controls the generation of regulatory T cells and imposes a developmental legacy on the effector function of peripheral regulatory T-cells.
Image credit: pbio.2006716
03/11/2019
Methods and Resources
Use of synthetic biology to couple methylation to growth allows the in vivo evolution of SAM-dependent methyltransferases and their associated metabolic pathways.
Image credit: Wikimedia Commons user SubDural12
03/05/2019
Short Reports
Analysis of more than two billion page views over three years for Wikipedia articles for 31,751 species across 245 languages reveals that many species show a seasonal pattern, and several online variations mirror real-world phenology.
Image credit: Flickr user Ken Gibson
03/05/2019
Short Reports
Brewer's yeast has been used to make fermented beverages for millennia. A genome analysis of beer and other yeast strains shows that beer yeast have a polyploid admixed origin derived from European and Asian wine populations.
Image credit: Flickr user Alan Levine
03/01/2019
Research Article
Rod photoreceptors in the retina play a major role in the phase-shifting response of the mammalian retinal clock to high levels of light, while melanopsin and mid-wavelength cones influence the intrinsic period of the clock.
Image credit: pbio.2006211
Susanna Bidgood explores the future of using poxviruses as versatile tools for cell biology research.
Rachel Harding proposes that open notebooks present an opportunity for researchers to showcase their work and rapidly advance science in their field
On the eve of the UN General Assembly meeting on TB, Christoph Grundner urged the need to consider basic research as an essential component of any future anti-TB strategy.
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
Rodrigo Almeida argues that considering the social context of emerging plant diseases and effective science communication are essential for the management epidemics.
Meet Senior Editor Ines Alvarez-Garcia in Keystone, CO.
January 27-31, 2019
Meet Senior Editor Lauren Richardson in La Jolla, CA.
January 22-24, 2019
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