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Exploring the tumor microenvironment

July 1, 2022

Exploring the tumor microenvironment

Tao Chen, Chen Cao, Jianyun Zhang, Aaron Streets, Tiejun Li and Yanyi Huang combine label-free histology with genomic analysis, allowing spatially resolved characterization of genomic and transcriptomic heterogeneity in human oral squamous cell carcinoma.


Image credit: pbio.3001699

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

06/30/2022

Research Article

Why do so many human IVF embryos arrest?

Human embryos develop poorly in vitro, and as much as 60% of embryos will irreversibly arrest. Yang Yang, Liyang Shi, Andrew Hutchins, Guoqing Tong and colleagues show that the arrested embryos enter a senescent-like state; several mechanisms related to zygotic genome activation problems and erroneous metabolism can explain some of the reasons behind this arrest.

Image credit: pbio.3001682

Why do so many human IVF embryos arrest?

Recently Published Articles

Current Issue

Current IssueJune 2022

06/30/2022

Methods and Resources

Fishing for ubiquitylated proteins

Mengwen Zhang, Mark Hochstrasser and co-workers present OtUBD, a new tool derived from a bacterial deubiquitylase, for the purification and analysis of a broad range of endogenous ubiquitylated proteins, including monoubiquitylation, polyubiquitylation, non-lysine ubiquitylation and potentially other macromolecules.

Image credit: pbio.3001501

Fishing for ubiquitylated proteins

06/29/2022

Essay

The origin of RNAi: adaptive or neutral evolution?

Where did RNA interference come from? Alessandro Torri, Maria-Carla Saleh and co-authors describe a new step-by-step evolutionary model of how RNA interference might have originated in early eukaryotes through neutral events from the molecular machinery present in prokaryotes.

Image credit: pbio.3001715

The origin of RNAi: adaptive or neutral evolution?

06/28/2022

Primer

The role of visual gamma oscillations

Brett Foster and Eleonora Bartoli explore the implications of a recent PLOS Biology study showing that gamma synchrony in visual cortex is disrupted when small discontinuities are added to visual stimuli. This suggests that gamma synchrony is highly sensitive to regularities in the visual world and potentially plays a role in predictive processing.

The role of visual gamma oscillations

Image credit: pbio.3001701

06/28/2022

Community Page

BirdNET app promotes global bird research via citizen science

Connor Wood, Holger Klinck and co-authors argue that involving the general public in research through free bird sound identification apps such as BirdNET can generate tens of millions of bird observations globally, helping citizen science to power avian ecology.

BirdNET app promotes global bird research via citizen science

Image credit: pbio.3001670

06/23/2022

Short Reports

The history of snake fungal disease

Snake fungal disease is emerging in eastern North America, but its origins have been unclear. Jason Ladner, Jeffrey Lorch and colleagues use population genetic data to show that the fungus that causes the disease was introduced multiple times to North America over the last few hundred years.

The history of snake fungal disease

Image credit: pbio.3001676

06/22/2022

Methods and Resources

Database of transmission trees to explore superspreaders

A compilation of infectious disease transmission trees enables analysis of trends in superspreader frequency and generation, suggesting that superspreaders beget other superspreaders.

Database of transmission trees to explore superspreaders

Image credit: pbio.3001685

06/21/2022

Research Article

Out of breath?

Response to acute oxygen shortage is crucial for aerobic life, but its molecular mechanisms are poorly understood. This study reveals that high levels of cGMP and ROS prevent the nematode C. elegans from escaping hypoxia.

Out of breath?

Image credit: pbio.3001684

06/21/2022

Research Article

Chemical dialogue between bacterial pathogens

An unbiased genome-scale approach reveals multiple Staphylococcus aureus secreted factors that are sensed by co-infecting pathogen Pseudomonas aeruginosa.


Chemical dialogue between bacterial pathogens

Image credit: Erina He, NIH Medical Arts

06/16/2022

Perspective

The importance of tropical research

The integration of authentic research in tropical biology could promote internationality among scientists and provide experiential learning that enables students to address complex global problems.

The importance of tropical research

Image credit: J. Leighton Reid

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PLOS Biology | ISSN: 1545-7885 (online)