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Downregulate contractility to invade

January 6, 2021

Downregulate contractility to invade

During gastrulation, the mesoderm “invades” the interior of the developing embryo. Leily Kashkooli, David Rozema, François Fagotto and co-authors reveal that its phenomenal capacity for fast migration while remaining cohesive is triggered by simple downregulation of cell contractility through the expression of two tissue-specific myosin regulators.

Image credit: pbio.3001060

PLOS Biologue

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PLOS BIOLOGUE

01/07/2021

Research Article

Opsins for behavior, not sight

Why do fish possess more than 40 opsins, many expressed outside the eyes? Bruno Fontinha, Theresa Zekoll, Kristin Tessmar-Raible and colleagues reveal that combined loss of two non-visual opsins rescues the effects of their individual losses on behavior and gene expression, implicating tmt-opsin-expressing cells, together with other opsins, in behavioral fine-tuning, dependent on ambient light.

Image credit: pbio.3001012

Opsins for behavior, not sight

Recently Published Articles

Current Issue

Current Issue December 2020

01/06/2021

Research Article

How to prevent a threesome

During sexual reproduction, fertilization must happen between exactly two gametes to ensure genome stability. Aleksandar Vještica, Sophie Martin and co-authors show that two mechanisms – establishment of zygotic fate and re-entry to the cell cycle – combine to prevent fission yeast zygotes fusing with further gametes.

Image credit: Aleksandar Vještica & Sophie Martin

How to prevent a threesome

01/04/2021

Research Article

Changes in the Lyme disease heart

Lyme carditis is a manifestation of Lyme disease characterized by episodes of atrioventricular block and additional cardiomyopathies. Diego Barriales, Juan Anguita and colleagues describe the proteomic and transcriptomic changes in the heart upon infection with Borrelia burgdorferi, and identify innate immune memory hallmarks specific to the response to the spirochete that are amenable to therapeutic manipulation.

Image credit: pbio.3001062

Changes in the Lyme disease heart

01/04/2021

Research Article

The cell cycle controls receptor distribution

Christina Cota, Brad Davidson and co-workers provide fundamental insights into the crosstalk between cell division and signaling, with implications for cancer. High-resolution in vivo analysis reveals that dividing cells sequester signal receptor proteins into internal compartments; stored receptors are then redistributed as cells complete division.

The cell cycle controls receptor distribution

Image credit: pbio.3001029

12/31/2020

Methods and Resources

Chimp white matter atlas

Katherine Bryant, Rogier Mars and colleagues use diffusion MRI tractography to reveal the first complete atlas of white matter of the chimpanzee, with the potential to help understand differences between the organization of human and chimpanzee brains.

Chimp white matter atlas

Image credit: Katherine Bryant

12/31/2020

methods and resources

Where do antibiotics go?

Antony Fearns, Haibo Jiang, Maximiliano Gutierrez and co-workers use correlative light, electron and ion microscopy (CLEIM) in vivo to reveal the intracellular fate of an antibiotic in lung lesions of mice infected with Mycobacterium tuberculosis, with organelle-level resolution.

Where do antibiotics go?

12/30/2020

Methods and Resources

Nanopore scRNA-seq analysis of mouse embryos

A novel technology called SCAN-seq can capture the full-length transcripts in single cells based on the Nanopore sequencing platform; its performance is demonstrated on mouse preimplantation embryos.

Nanopore scRNA-seq analysis of mouse embryos

Image credit: pbio.3001017

12/30/2020

Research Article

How EPEC triggers pyroptosis in the gut

A novel mechanism by which infection with enteropathogenic E. coli (EPEC) leads to pyroptosis in intestinal epithelial cells; this process is dependent on the type III secretion system effector Tir, and enhanced by priming with IFNγ.

How EPEC triggers pyroptosis in the gut

Image credit: pbio.3000986

12/28/2020

Discovery Report

Convergent evolution of anthrax outbreaks

A study of the spontaneous loss of the spore coat monosaccharide anthrose in Bacillus anthracis suggests that convergent evolution in several anthrax strains towards increased pathogenicity could exacerbate global human and animal anthrax disease.

Convergent evolution of anthrax outbreaks

Image credit: Michael Norris

12/28/2020

Research article

Eicosapentaenoic acid regulates glial size

This study in nematodes reveals eicosapentaenoic acid as the downstream product of a pathway that functions to prevent the overgrowth of glia, suggesting a novel and potentially conserved mechanism underlying glial size control.

Eicosapentaenoic acid regulates glial size

Image credit: pbio.3001051

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