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Architecture of the nematode centriole

September 15, 2022

Architecture of the nematode centriole

The nematode centriole was key in identifying components involved in centriole assembly, but its small size has hampered the localization of those components. Alexander Woglar, Pierre Gönczy and co-workers use a combination of microscopy techniques to reveal the molecular architecture of the nematode centriole in unprecedented detail.

Image credit: pbio.3001784

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Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

09/14/2022

Research Article

Natural coding for a vestibular prosthesis

Recent advances have created new opportunities for applying our understanding of the brain to sensory prothesis development. This study in macaques by Kantapon Pum Wiboonsaksakul, Kathleen Cullen and colleagues shows that by implementing natural coding strategies, the precision of vestibular prosthesis performance can be enhanced.

Image credit: pbio.3001798

Natural coding for a vestibular prosthesis

Recently Published Articles

Current Issue

Current Issue August 2022

09/14/2022

Discovery Report

Ignore ghosts at your peril

Extinct and unknown species are overlooked in evolutionary studies of gene flow. Théo Tricou, Eric Tannier and Damien de Vienne show that taking such "ghost lineages" into account changes the conclusions of several studies on this subject.

Image credit: pbio.3001776

Ignore ghosts at your peril

09/13/2022

Research Article

Genes take an adaptive walk

Ana Filipa Moutinho, Adam Eyre-Walker and Julien Dutheil use population genomic datasets from Arabidopsis and Drosophila to show that young genes adapt faster and are subject to mutations of larger fitness effects, providing strong evidence that molecular evolution follows an adaptive walk model across a large evolutionary timescale.

Image credit: Martina Pepiciello

Genes take an adaptive walk

09/13/2022

Discovery Report

First responders in pancreatic islets

A hallmark of the early stages in diabetes is the disruption of the first-phase peak of insulin secretion. Vira Kravets, Richard Benninger and colleagues reveal a state of beta cells that drives the first-phase calcium response (a precursor to insulin secretion), challenging the existing paradigm that first-phase calcium response to glucose is not organized within the islet.

First responders in pancreatic islets

Image credit: pbio.3001761

09/13/2022

Short Reports

Defensosome decoys for SARS-CoV-2 infection

Autophagy proteins mediate the production of extracellular vesicles termed defensosomes in response to innate immune ligands. Krystal Ching, Meike Dittmann, Victor Torres, Ken Cadwell and co-authors reveal that ACE2-containing defensosomes bind and inhibit SARS-CoV-2 infection, and are associated with reduced length of hospital stay for patients with COVID-19. Read the accompanying Primer by Sonja Fernbach and Benjamin Hale.

Defensosome decoys for SARS-CoV-2 infection

Image credit: pbio.3001754

09/13/2022

Research Article

Vimentin regulates cell size and autophagy

The nutrient-activated mTORC1 signaling pathway determines cell size by controlling protein synthesis and autophagy. Ponnuswamy Mohanasundaram, Leila Coelho-Rato, John Eriksson and colleagues show that the cytoskeletal intermediate filament protein vimentin determines cell size through mTORC1 signaling, an effect that is also seen at the organism level in mice.

Vimentin regulates cell size and autophagy

Image credit: pbio.3001737

09/12/2022

Meta-Research Article

Blind spots on western blots

This systematic assessment of more than 500 articles reveals that western blot figures and methods often omit essential details. The study also provides recommendations to help scientists avoid common problems.

Blind spots on western blots

Image credit: pbio.3001783

09/12/2022

Short Reports

Humans as habitat

An analogy between ecological succession in terrestrial ecosystems and infections in a human-host landscape over time reveals the importance of considering how the ecosystem of long-term multi-pathogen dynamics within and among hosts.

Humans as habitat

Image credit: pbio.3001770

09/12/2022

Research Article

Explaining variable responses to BCG vaccination

The response to the BCG vaccine is variable. This study shows that the plasma metabolome can partially predict trained immunity upon BCG vaccination, identifying the metabolome as a potential source of heterogeneity.

Explaining variable responses to BCG vaccination

Image credit: pbio.3001765

09/08/2022

Research Article

Gender and scientific mentorship

Why are graduate and postdoctoral trainees of women mentors less likely to continue on to positions as academic mentors than trainees of men? This study finds that gender inequality in mentors' access to resources contributes to this disparity.

Gender and scientific mentorship

Image credit: pbio.3001771

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PLOS Biology | ISSN: 1545-7885 (online)