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Networking NLRs Defend Plants

December 12, 2018

Networking NLRs Defend Plants

Tadeusz Wróblewski, Frank Takken and co-authors show that once a pathogen is detected, plants use the N-terminal coiled-coil domains of nucleotide-binding leucine rich receptors (NLRs) to trans-activate other immune receptors and form heteromeric complexes that initiate defense.

Image credit: T. Wroblewski

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PLOS Biology's XV Collection

12/10/2018

Research Article

Adapting to Life in the Gut

 A study of bacterial adaptation to the vertebrate gut, by Catherine Robinson, Karen Guillemin, Brendan Bohannan and co-workers, challenges assumptions about the primary importance of the intra-host environment, instead highlighting the significance of bacterial immigration and transmission in persistent host-microbe interactions.

Image credit: pbio.1002517

Adapting to Life in the Gut

Recently Published Articles

Current Issue

Current Issue November 2018

12/13/2018

RESEARCH ARTICLE

Parents' Brains Echo Kids' Brains during Play

Sam Wass, Vicky Leong and colleagues examine how information is shared between infants and parents by using dual EEG recording during joint play. The results suggest that where the parent is more neurally responsive, the infant is more attentive. Read the accompanying Primer.

Image credit: pbio.3000074

Parents' Brains Echo Kids' Brains during Play

12/12/2018

SHORT REPORTS

Does Chromatin Get in the Way of CRISPR?

Eirini Kallimasioti-Pazi, Andrew Wood and co-authors find that the chromatin environment of CRISPR-Cas9 target sites affects the rate at which mutations accumulate, but not the types of mutation that arise or their frequency following prolonged exposure to Cas9.

Image credit: pdb101

Does Chromatin Get in the Way of CRISPR?

12/11/2018

RESEARCH ARTICLE

Maintaining Variation in the Face of Selection

Experiments with seed beetles by Karl Grieshop and Göran Arnqvist show that opposite alleles at polymorphic loci encoding fitness are dominant in heterozygous males versus females; this enables sexually antagonistic selection to maintain genetic variation for fitness. 

Maintaining Variation in the Face of Selection

Image credit: Richard001, Wikimedia

12/10/2018

Essay

Analysis Validation: Neglected in the Age of Reproducibility

Just as we do controls for experiments we should all do controls for data analysis – this is easy to say but requires dedication to implement. This Essay, by Kathleen Lotterhos, Jason Moore and Ann Stapleton, explains the need for analysis validation and provides specific suggestions for how to get started.

Analysis Validation: Neglected in the Age of Reproducibility

Image credit: Janeke88, Pixabay

12/10/2018

RESEARCH ARTICLE

The Liver's Response to a Good Meal

A genome-wide study by Adrija Kalvisa, Majken Siersbæk, Lars Grøntved and co-workers identifies those gene regulatory regions which in the liver are controlled by feeding, and reveals that glucocorticoid and insulin signaling pathways cooperatively regulate post-prandial repression of gene expression. 

The Liver's Response to a Good Meal

Image credit: Takometer, Wikimedia

12/12/2018

RESEARCH ARTICLE

Plant Pathogen Resistance Networks

Analyses of immunity-related signal transduction, using tomato plants infected with the bacterium Pseudomonas syringae, reveal rules of molecular communication between plants and pathogens governing resistance and susceptibility phenotypes.

Plant Pathogen Resistance Networks

Image credit: pbio.2005956

12/11/2018

Formal Comment

Far Away from the Lamppost

This Formal Comment responds to a recent Meta-Research Article by identifying initiatives that are already in place for funding risky exploratory research that illuminate mysteries of the dark genome. The original authors respond.

Far Away from the Lamppost

Image credit: Kristine Paulus, Flikr

12/13/2018

Methods & Resources

Single-Molecule Membrane Protein Interactions

A co-immunoimmobilization assay lets you see transient protein-protein interactions at the single-molecule level in the membranes of living cells, on the basis of the protein’s intrinsic diffusivity.

Single-Molecule Membrane Protein Interactions

Image credit: pbio.2006660

12/13/2018

Methods & Resources

High-Throughput Phenomics

EmbryoPhenomics - an open source platform for high-throughput phenome screening of aquatic embryos; this proof-of-principle comprises >30 million images, assessing the sensitivity of >600 aquatic embryos to environmental stress.

High-Throughput Phenomics

Image credit: pbio.3000074

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