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Recouping Lost Neurons; a Tale of Serotonin and Glia

January 6, 2020

Recouping Lost Neurons; a Tale of Serotonin and Glia

Can regeneration of lost neurons counteract neurodegenerative disease? Prabesh Bhattarai, Caghan Kizil and colleagues show that serotonergic neurons alter neural stem cell proliferation and neurogenesis via a complex neuron-glia interaction involving interleukin-4, BDNF and NGF receptor in a zebrafish model of Alzheimer's disease.

Image credit: Prabesh Bhattarai/Kizil Lab, DZNE

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology

PLOS Biologue

01/10/2020

community page

An Ultra-Low–Cost, Portable Electroporator

Gaurav Byagathvalli, Saad Bhamla and co-authors describe an ultra-low cost (23-cent) 3D-printed electroporator, inspired by a common barbecue lighter, and designed to enable broader access to synthetic biology in high school, community and budget-conscious laboratories.

Image credit: pbio.3000589

An Ultra-Low–Cost, Portable Electroporator

Recently Published Articles

Current Issue

Current Issue December 2019

01/06/2020

research article

Intrinsic Plasticity of Purkinje Cells

Giorgio Grasselli, Henk-Jan Boele, Chris de Zeeuw, Martijn Schonewille, Christian Hansel and co-workers show that cerebellum-dependent motor learning involves an adjustment of membrane excitability in Purkinje cells via modulation of SK2-type K+ channels; this "intrinsic plasticity" requirement can be separated from changes in synaptic strength.

Image credit: pbio.3000596

Intrinsic Plasticity of Purkinje Cells

01/02/2020

research article

Alternative Repair of Telomeric Breaks

The chromatin remodeller ATRX is often lost in cells that maintain their telomeres using the telomerase-independent “alternative lengthening of telomeres” (ALT) pathway. Courtney Lovejoy, Titia de Lange and co-workers show how loss of ATRX alters the repair of telomeric DNA breaks and suggests how this change could promote telomere maintenance in ALT cells.

Image credit: pbio.3000594

Alternative Repair of Telomeric Breaks

12/26/2019

research article

Human Sperm Rapidly Responds to Diet

Daniel Nätt, Unn Kugelberg, Anita Öst and colleagues find that sperm motility in healthy young men is highly sensitive to diet and is associated with changes in specific populations of tRNA fragments. In non-human animals, similar molecular changes correlate with metabolic effects in the offspring. These results not only show that human sperm may rapidly respond to diet, but that these changes may potentially ripple into the next generation.

Human Sperm Rapidly Responds to Diet

Image credit: pbio.3000559

12/20/2019

research article

How Does CETP Inhibition Reduce Heart Disease Risk?

Johannes Kettunen, Michael Holmes, Elias Allara, Olga Anufrieva, Emanuele Di Angelantonio, Adam Butterworth, Mika Ala-Korpela and colleagues reveal that inhibition of cholesteryl ester transfer protein does not affect size-specific low-density lipoprotein cholesterol, but may lower coronary heart disease risk by lowering cholesterol concentrations in other apolipoprotein-B containing atherogenic lipoproteins.

How Does CETP Inhibition Reduce Heart Disease Risk?

Image credit: pbio.3000572

12/19/2019

Methods and Resources

Anatomy of the Lymph Node

Extended-volume confocal imaging by Inken Kelch, Rod Dunbar and co-authors allows 3D visualisation of the fine network of conduits within lymph nodes; the resulting map of conduit topology underscores structural differences between the deep and superficial T cell zone and identifies "follicular reservoirs" within B cell follicles that concentrate lymphoid fluid around follicular dendritic cells.

Anatomy of the Lymph Node

Image credit: Inken D. Kelch

12/19/2019

Methods and Resources

Organelle Behavior Revealed

Holo-tomographic microscopy and computer vision allow label-free observation of novel shape and dry mass dynamics of mammalian organelles such as lipid droplets and the investigation of complex organellar motion.

Organelle Behavior Revealed

Image credit: pbio.3000553

12/17/2019

Research Article

How Glioblastoma Triggers Neurodegeneration

Cells from the lethal brain tumor glioblastoma compete with healthy neurons for survival, depleting the signaling molecule Wg and causing neurodegeneration.


How Glioblastoma Triggers Neurodegeneration

Image credit: Sergio Casas-Tintó

12/13/2019

Research Article

Holding Back Immature Ribosomes 

The kinase Rio1, the nuclease Nob1, and its partner Pno1 establish a checkpoint that prevents the escape of immature ribosomes into polysomes. Bypass perturbs ribosome fidelity and mRNA specificity, and can be caused by cancer mutations.

Holding Back Immature Ribosomes 

Image credit: pbio.3000329

12/16/2019

Research Article

Synaptic Function for Hominid-Specific Deubiquitinase

The hominoid-specific USP6 is a novel deubiquitinase of NMDA receptors. Expression of a human USP6 transgene enhances cognitive and synaptic function in mice, suggesting a role in evolution of human intelligence.

Synaptic Function for Hominid-Specific Deubiquitinase

Image credit: pbio.3000525

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