05/06/2021
Methods and Resources
By integrating single-cell firing behavior during in vivo oscillations with morphological and molecular neuron classification in vitro, Alberto Sanchez-Aguilera, Diek Wheeler, Liset de la Prida, Giorgio Ascoli and colleagues standardize a framework for interpreting the functional roles of distinct circuit modules and ascribing extracellular recordings to identified neuron types.
Image credit: pbio.3001213
Current Issue April 2021
05/05/2021
Research Article
Timo Stein, Simon van Gaal and co-workers show that the extent of unconscious information processing in human visual cortex is determined by the measurement approach; only subjectively, but not objectively, invisible stimuli are represented at a categorical level.
Image credit: pbio.3001241
05/04/2021
Essay
Notions of how neural oscillations behave are as ubiquitous as their occurrence throughout the brain. But where do such notions come from? Using a normal form oscillator model, Keith Doelling and Florencia Assaneo refute a list of the most commonly held ideas of how an oscillator should behave and generate a series of cautionary examples to emphasize the findings.
Image credit: pbio.3001234
05/04/2021
RESEARCh article
Aleksandra Lubojemska, Alex Gould and co-authors use a high-fat diet model of chronic kidney disease in Drosophila to reveal that boosting triglyceride lipolysis in renal cells is sufficient to rescue renal cell function via a pathway involving PGC1 alpha and mitochondria.
Image credit: A Lubojemska, A Yoshimura, L Collinson & AP Gould
05/04/2021
Essay
Most Gene Expression Omnibus (GEO) depositions of single-cell mRNA sequencing data do not include cell-level metadata generated by typical analysis pipelines; Sidhant Puntambekar, Kent Riemondy, Rui Fu and co-authors argue that this omission greatly hinders reproduction, exploration, validation, and knowledge transfer and is a common problem across journals, data repositories, and publication dates.
Image credit: pbio.3001077
05/03/2021
Perspective
Genomic research led the way in open science – a tradition continued by genome-wide association studies – through the sharing of materials, results and data. Coordinated quality control procedures also contributed to robust findings. But Callie Burt and Marcus Munafò wonder whether these standards are now slipping back...
Image credit: pbio.1001661
05/03/2021
Research Article
Behaviorally-specific patterns of correlated activity between prefrontal neurons normally enhance the information that neuronal ensembles transmit about social behavior. In a mouse model of autism, this additional information carried by patterns of correlated activity is lost.
Image credit: pbio.3001235
05/03/2021
Research article
A cell-based screen identifies a small molecule, Y-320, that potently enhances readthrough of premature termination codons by the aminoglycoside G418. Y-320 increases cellular protein levels and protein synthesis, and appears to act via an autocrine chemokine signaling pathway.
Image credit: pbio.3001221
04/29/2021
Research Article
The cryo-EM structure of the N501Y mutant version of the SARS-CoV-2 spike protein in complex with its receptor ACE2 reveals the intermolecular interactions that may underlie the increasing prevalence of the B.1.1.7 SARS-CoV-2 variant.
Image credit: pbio.3001237
04/29/2021
Research Article
An evaluation of the performance of SARS-CoV-2 antigen lateral flow devices, validated using PCR, concludes that they do not detect infections presenting with higher PCR Ct values, reinforcing the need for frequent, recurrent testing.
Image credit: Unsplash user Anne Spratt
Raquel Lieberman discusses her work on the protein myocilin, implicated in glaucoma, but whose normal function remains unclear after over 20 years.
Susanna Bidgood explores the future of using poxviruses as versatile tools for cell biology research.
Rachel Harding proposes that open notebooks present an opportunity for researchers to showcase their work and rapidly advance science in their field
On the eve of the UN General Assembly meeting on TB, Christoph Grundner urged the need to consider basic research as an essential component of any future anti-TB strategy.
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
May 10-12
Meet senior editor Gabriel Gasque
May 11-14
Meet senior editor Roli Roberts
May 11-14
Meet associate editor Richard Hodge
May 24-26
Meet associate editor Paula Jauregui
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