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Gut Bugs and Lifestyle in Himalaya

November 15, 2018

Gut Bugs and Lifestyle in Himalaya

Analysis of gut microbiome profiles from human Himalayan populations practicing diverse subsistence strategies, by Aashish Jha, Justin Sonnenburg and co-workers, shows that colonic microbial communities change as humans shift away from foraging.

Image credit: pbio.2005396

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PLOS Biology's XV Collection

11/15/2018

RESEARCH ARTICLE

Network Evolution when the Hub Changes

Tracy Chih-Ting Koubkova-Yu, Jung-Chi Chao, and Jun-Yi Leu show that yeast cells carrying the heat shock protein Hsp90 from a distant species,Yarrowia, have an increased potential to evolve divergent phenotypes after propagating under normal growth conditions for thousands of generations.

Image credit: pbio.2006450

Network Evolution when the Hub Changes

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Current Issue

Current Issue October 2018

11/14/2018

RESEARCH ARTICLE

Integrins Snorkel Lipids

Jun Guo, Youhua Zhang, Hua Li, Huiying Chu, Guohui Li, Jianfeng Chen, Chenqi Xu and colleagues find that calcium regulates the structure and function of integrin by disrupting an interaction between a “snorkeling” basic amino acid and an acidic phospholipid within the membrane.

Image credit: pbio.2006525

Integrins Snorkel Lipids

11/16/2018

research article

Diverse Calcium Sensors in the ER

A protein engineering approach by Sisi Zheng, Guolin Ma, Lian He, Yubin Zhou, Youjun Wang and colleagues delineates how two STIM homologs, STIM1 and STIM2, differentially sense and respond to calcium signals, overcome intramolecular autoinhibition, and trigger calcium influxes into mammalian cells.

Image credit: pbio.2006898

Diverse Calcium Sensors in the ER

11/13/2018

FORMAL COMMENT

Biodiversity Assessments: Origin matters

This Formal Comment by Aníbal Pauchard and co-authors responds to a previous Perspective article by Martin Schlaepfer, acknowledging that more comprehensive assessments of global biodiversity including native and non-native species are needed, but maintaining that we must resist the temptation to oversimplify the concept of biodiversity. See also Schlaepfer's reply.

Biodiversity Assessments: Origin matters

Image credit: bewildlife, Pixabay

11/12/2018

RESEARCH ARTICLE

Chromosome Mis-Segregation and Hybrid Sterility

David Rogers, Ellen McConnell, Jasmine Ono and Duncan Greig show that low levels of genome sequence divergence can keep yeast populations reproductively isolated by interfering with the segregation of chromosomes during gamete production in hybrids, thereby resulting in hybrid sterility.

Chromosome Mis-Segregation and Hybrid Sterility

Image credit: pbio.2005066

11/09/2018

SHORT REPORTS

Propelling the Lyme Disease Pathogen

Cryo-electron tomography of periplasmic flagella in the Lyme disease bacterium Borrelia burgdorferi, by Zhuan Qin, Jiagang Tu, Md Motaleb, Jun Liu and colleagues reveals a distinct cytoplasmic ATPase complex and an atypical interaction with the flagellar C-ring.

Propelling the Lyme Disease Pathogen

Image credit: pbio.3000050

11/08/2018

methods and resources

Sleeping or Just Pretending?

Gamma oscillations in the olfactory bulb track changes in vigilance states with remarkable precision, allowing the development of a novel fully brain-based sleep-scoring methodology.

Sleeping or Just Pretending?

Image credit: pbio.2005458

11/08/2018

RESEARCH ARTICLE

TRIM59, PDCD10 and Breast Cancer Metastasis

Bioinformatic analysis and experiments unveil a new signaling protein degradation pathway involving TRIM59 and PDCD10 that modulates breast cancer cell growth, survival, and metastasis.

TRIM59, PDCD10 and Breast Cancer Metastasis

Image credit: pbio.3000051

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