07/03/2025
Research Article
The accumulation of the ganglioside GM2 can lead to gangliosidoses such as Tay-Sachs and Sandhoff diseases. Alex Nicholson, Janet Deane and co-workers develop a new, in vitro, neuron-based model of GM2 gangliosidoses, revealing changes in the protein and lipid composition of the plasma membrane that impact neuronal firing.
Image credit: pbio.3003265
Current Issue June 2025
07/03/2025
Methods and Resources
Expansion microscopy facilitates multiple rounds of antibody staining and imaging, but this requires high-quality registration of images between rounds. Hyunwoo Kim, Joon-Goon Kim, Seoungbin Bae, Young-Gyu Yoon, Taeyun Ku, Jae-Byum Chang and co-authors develop a superior image registration technique using dense NHS-ester labels for multiplexed cyclic imaging in expandable tissue gels.
Image credit: pbio.3003240
07/03/2025
Research Article
Group B Streptococcus bacteria cause meningitis when they cross the endothelial cells of the blood-brain barrier, but how they traverse it remains unclear. Sumedha Ravishankar, Cressida Madigan and colleagues show that bacteria perforate and lyse endothelial cells in the brain blood vessels, facilitating brain invasion in zebrafish.
Image credit: pbio.3003236
07/01/2025
Research Article
Different cortical regions have been implicated in mathematical learning, but their causal role is less clear. George Zacharopoulos, Roi Cohen Kadosh and co-workers reveal the causal role of the dorsolateral prefrontal cortex and the frontoparietal network in mathematical learning using transcranial neuromodulation in human participants.
Image credit: pbio.3003200
06/30/2025
Research Article
BACE1 cleaves amyloid precursor proteins to generate Aβ which may contribute to Alzheimer's Disease (AD) pathogenesis. Shaokun Chen, Jie Zhang and co-authors show that the G protein subunit β5 gene (Gnb5) is a negative regulator of BACE1 and that overexpression of Gnb5 reduces Aβ deposition and ameliorates cognitive defects in a mouse model of AD.
Image credit: pbio.3003259
06/30/2025
Research Article
Waterhemp has recently evolved separate male and female plants within a genus where most species have both sexes on one plant. Julia Kreiner, Stephen Wright and colleagues reveal surprising chromosomal diversity and complexity associated with this transition, challenging our understanding of how separate sexes evolve.
Image credit: Julia Kreiner
06/30/2025
Editorial
AI tools can aid almost every aspect of the research process, from hypothesis generation and data analysis to manuscript drafting and publication. This Editorial explores what the future might hold for researchers and publishers.
Image credit: Unsplash user Igor Omilaev
06/23/2025
Perspective
A career in science can come with a high price tag. This Perspective explores how persistent financial barriers limit who can succeed in science, and proposes structural changes to support equity and inclusion.
Image credit: Pixabay user kschneider2991
06/23/2025
Perspective
As the availability and performance of AI for language editing and translation continues to improve, we can imagine a future in which everyone can use their own language to write, assess and read science. The question is, how can we achieve it?
Image credit: pbio.3003215
06/20/2025
Perspective
Educational equity faces renewed threats across higher education in the United States. This Perspective addresses what can be done by life science instructors and researchers to prioritize equitable, evidence-based teaching for all.
Image credit: Unsplash user Sam Balye
Neurotechnology offers unprecedented opportunities to treat neural disorders, restore brain function and enhance cognitive abilities. This collection explores the present and possible futures of neurotechnology to improve human health and cognition.
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
July 8 - 9
Meet Senior Editor Christian Schnell (cschnell@plos.org)
July 13 - 17
Meet Senior Editor Ines Alvarez-Garcia (ialvarez-garcia@plos.org)
July 20 - 24
Meet Senior Editor Roli Roberts (rroberts@plos.org)
August 26 - 30
Meet Senior Editor Richard Hodge (rhodge@plos.org)
September 9 - 12
Meet Senior Editor Ines Alvarez-Garcia (ialvarez-garcia@plos.org)
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