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Arrested eggs activate the zygotic genome with fewer nuclei

October 22, 2020

Arrested eggs activate the zygotic genome with fewer nuclei

Isaac Strong, Xiaoyun Lei, Fang Chen, Kai Yuan, and Patrick O’Farrell show that arresting the cell cycle bypasses the requirement of a threshold nuclei-to-cytoplasm ratio for activating the zygotic genome and other mid-blastula transition events in Drosophila early embryos.

Image credit: pbio.3000891

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

10/22/2020

Editorial

We need leaders that believe in scientific evidence

In a world beset by attempts to undermine scientific evidence and evidence-based policy, Nonia Pariente and the PLOS Biology staff editors emphasize the important role that these should play in helping humanity rise to the challenges of our time.

Image credit: Wikimedia Users 159753 & Smartskaft

We need leaders that believe in scientific evidence

Recently Published Articles

Current Issue

Current Issue September 2020

10/22/2020

Primer

The power (and mechanism) of tACS.

Mircea van der Plas and Simon Hanslmayr explore the implications of two recent studies, one showing that transcranial alternating current stimulation (tACS) entrains single neurons in the brain, and the other that 30 Hz stimulation (via tACS) improves reading abilities in individuals with dyslexia. These studies show how tACS can affect neural processing in the brain in order to improve cognition in humans.

Image credit: pbio.3000931

The power (and mechanism) of tACS.

10/22/2020

Research Article

Attending and ignoring at the cocktail party

How do humans focus on one speaker when several are talking? Christian Brodbeck, Jonathan Simon and colleagues find that MEG responses to a continuous two-talker mixture suggest that, even though listeners attend only to one of the talkers, their auditory cortex tracks acoustic features from both speakers. This occurs even when those features are locally masked by the other speaker.

Image credit: pbio.3000883

Attending and ignoring at the cocktail party

10/22/2020

Research Article

Predicting evolution in response to vaccines

Predicting how pathogen populations will change over time is challenging. Taj Azarian, Pamela Martinez, Marc Lipsitch, William Hanage and co-authors predict population changes in human pathogen Streptococcus pneumoniae after vaccination, using a model of negative frequency-dependent selection acting on accessory gene products.

Predicting evolution in response to vaccines

Image credit: Wikimedia user Manu5

10/22/2020

Short Reports

2 + 2 = ROBO1?

How does genetic variation give rise to differences in mathematical ability? Combining genotyping with brain imaging in children, Michael Skeide, the Legascreen Consortium and co-workers show that math performance can be predicted before school entry from individual volume differences of the right parietal cortex that are associated with variations in the cortical growth gene ROBO1.

2 + 2 = ROBO1?

Image credit: pbio.3000871

10/22/2020

Research Article

A gradient of whiskers

Facial whiskers are found in many mammalian species. Erez Gugig, Hariom Sharma and Rony Azouz examine the functional significance of their ordered structure, which is represented in a rostral-to-caudal gradient of mechanical, muscular, and neuronal response characteristics, for tactile exploration in rodents.

A gradient of whiskers

Image credit: pbio.3000699

10/20/2020

Research Article

The motor rhythm of perception

Movements overtly sample sensory information. This study shows that visual information sampling is not just synchronized to the (overt) movement dynamics, but to the internal (covert) dynamics of cortico-motor control.


The motor rhythm of perception

Image credit: pbio.3000898

10/19/2020

Research Article

A novel function for CDK2 activity at meiotic crossover sites

 CDK2 is essential for fertility and regulates several stages of meiosis. This study reveals that increased CDK2 activity leads to elevated numbers of meiotic crossovers, whereas lower CDK2 activity prevents crossovers.

A novel function for CDK2 activity at meiotic crossover sites

Image credit: pbio.3000903

10/13/2020

Research Article

The phage resistance landscape

To map the landscape of genetic determinants important in host-phage interactions, this study applies unbiased high-throughput loss-of-function and gain-of-function screening methods to two different strains of E. coli confronted by a panel of 13 dsDNA phages.

The phage resistance landscape

Image credit: pbio.3000877

10/16/2020

perspective

COVID-19 and traditional academic reward structures

The pandemic has revealed the importance of open and collaborative research projects, generally overlooked by traditional metrics. How can we ensure that these outputs – and the people who do them – are valued in academia?

COVID-19 and traditional academic reward structures

Image credit: Wikimedia Commons user Ytoyoda

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