05/10/2019
Research Article
Avnish Patel, Abigail Perrin, Michael Blackman, David Baker and colleagues use conditional gene knockout to show that cyclic AMP signalling is absolutely required for invasion of erythrocytes by malaria parasites. Quantitative mass spectrometry identifies the parasite proteins whose phosphorylation is adversely affected when cyclic AMP signalling is ablated.
Image credit: pbio.3000264
Current Issue April 2019
05/13/2019
Research Article
Malaria parasites have a remarkable capacity to continuously generate genetically diverse surface antigens, helping them to evade the host immune response. Xu Zhang, Kirk Deitsch and co-authors reveal the unusual recombination mechanism which accelerates the diversification of this gene family in Plasmodium falciparum, the most severe of the human malarial parasites.
Image credit: Flickr Mario Yordanov
05/13/2019
Short Reports
Some types of mutations occur more frequently than expected. Joshua Payne, Fabrizio Menardo, Sebastien Gagneux, Alex Hall and co-authors show that such bias — an excess of transitions over transversions — influences the evolution of antibiotic resistance in a key global pathogen, Mycobacterium tuberculosis.
Image credit: Flickr NIAID
05/13/2019
Research Article
The first structures of a family of organic anion transporters, by Jonathan Leano, Robert Stroud, Robert Edwards and colleagues reveal an interaction with protons that is conserved from bacterial transporters to the mammalian proteins that transport glutamate into synaptic vesicles.
Image credit: pbio.3000260
05/16/2019
Methods and Resources
Using gypsy elements in aging fruit flies, Yung-Heng Chang, Richard Keegan, Lisa Prazak and Josh Dubnau describe cellular labelling of endogenous retrovirus replication (CLEVR), an in vivo reporter system that allows the tracing of virus or LTR retrotransposon replication in tissues.
Image credit: pbio.3000278
05/14/2019
Research Article
Ching-Ho Chang, Ankita Chavan, Jason Palladino, Amanda Larracuente, Barbara Mellone and co-authors use long-read sequencing, CENP-A ChIP, and chromatin fiber imaging to reveal the composition and organization of Drosophila melanogaster centromeres, which have long remained elusive despite the high quality of this species’ genome assembly.
Image credit: pbio.3000241
05/14/2019
Research Article
HLH-30, the nematode orthologue of the mammalian MiT/TFE family of master regulators of lysosome biogenesis, plays a key role in survival under starvation and refeeding conditions.
Image credit: pbio.3000245
05/14/2019
Research Article
Uncleared apoptotic cells impair macrophage dispersal and wound responses, revealing a role for the receptor Simu in phagocytosis of necrotic cells and retention of macrophages at wounds.
Image credit: pbio.2006741
05/16/2019
Research Article
Conditioning antimicrobial treatment protocols on both point-of-care and carriage diagnostics can produce effective patient care that also selects against resistance.
Image credit: Pixabay
05/10/2019
Primer
Miguel Ángel García-Cabezas and Basilis Zikopoulos explore recent research into the common organizational principles and specializations of the cerebral cortex. Read the related Research Article.
Image credit: pbio.2005346
Susanna Bidgood explores the future of using poxviruses as versatile tools for cell biology research.
Rachel Harding proposes that open notebooks present an opportunity for researchers to showcase their work and rapidly advance science in their field
On the eve of the UN General Assembly meeting on TB, Christoph Grundner urged the need to consider basic research as an essential component of any future anti-TB strategy.
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
Rodrigo Almeida argues that considering the social context of emerging plant diseases and effective science communication are essential for the management epidemics.
Meet Senior Editor Ines Alvarez-Garcia in Keystone, CO.
January 27-31, 2019
Meet Senior Editor Lauren Richardson in La Jolla, CA.
January 22-24, 2019
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