01/07/2021
Research Article
Why do fish possess more than 40 opsins, many expressed outside the eyes? Bruno Fontinha, Theresa Zekoll, Kristin Tessmar-Raible and colleagues reveal that combined loss of two non-visual opsins rescues the effects of their individual losses on behavior and gene expression, implicating tmt-opsin-expressing cells, together with other opsins, in behavioral fine-tuning, dependent on ambient light.
Image credit: pbio.3001012
Current Issue December 2020
01/06/2021
Research Article
During sexual reproduction, fertilization must happen between exactly two gametes to ensure genome stability. Aleksandar Vještica, Sophie Martin and co-authors show that two mechanisms – establishment of zygotic fate and re-entry to the cell cycle – combine to prevent fission yeast zygotes fusing with further gametes.
Image credit: Aleksandar Vještica & Sophie Martin
01/04/2021
Research Article
Lyme carditis is a manifestation of Lyme disease characterized by episodes of atrioventricular block and additional cardiomyopathies. Diego Barriales, Juan Anguita and colleagues describe the proteomic and transcriptomic changes in the heart upon infection with Borrelia burgdorferi, and identify innate immune memory hallmarks specific to the response to the spirochete that are amenable to therapeutic manipulation.
Image credit: pbio.3001062
01/04/2021
Research Article
Christina Cota, Brad Davidson and co-workers provide fundamental insights into the crosstalk between cell division and signaling, with implications for cancer. High-resolution in vivo analysis reveals that dividing cells sequester signal receptor proteins into internal compartments; stored receptors are then redistributed as cells complete division.
Image credit: pbio.3001029
12/31/2020
Methods and Resources
Katherine Bryant, Rogier Mars and colleagues use diffusion MRI tractography to reveal the first complete atlas of white matter of the chimpanzee, with the potential to help understand differences between the organization of human and chimpanzee brains.
Image credit: Katherine Bryant
12/31/2020
methods and resources
Antony Fearns, Haibo Jiang, Maximiliano Gutierrez and co-workers use correlative light, electron and ion microscopy (CLEIM) in vivo to reveal the intracellular fate of an antibiotic in lung lesions of mice infected with Mycobacterium tuberculosis, with organelle-level resolution.
12/30/2020
Methods and Resources
A novel technology called SCAN-seq can capture the full-length transcripts in single cells based on the Nanopore sequencing platform; its performance is demonstrated on mouse preimplantation embryos.
Image credit: pbio.3001017
12/30/2020
Research Article
A novel mechanism by which infection with enteropathogenic E. coli (EPEC) leads to pyroptosis in intestinal epithelial cells; this process is dependent on the type III secretion system effector Tir, and enhanced by priming with IFNγ.
Image credit: pbio.3000986
12/28/2020
Discovery Report
A study of the spontaneous loss of the spore coat monosaccharide anthrose in Bacillus anthracis suggests that convergent evolution in several anthrax strains towards increased pathogenicity could exacerbate global human and animal anthrax disease.
Image credit: Michael Norris
12/28/2020
Research article
This study in nematodes reveals eicosapentaenoic acid as the downstream product of a pathway that functions to prevent the overgrowth of glia, suggesting a novel and potentially conserved mechanism underlying glial size control.
Image credit: pbio.3001051
Raquel Lieberman discusses her work on the protein myocilin, implicated in glaucoma, but whose normal function remains unclear after over 20 years.
Susanna Bidgood explores the future of using poxviruses as versatile tools for cell biology research.
Rachel Harding proposes that open notebooks present an opportunity for researchers to showcase their work and rapidly advance science in their field
On the eve of the UN General Assembly meeting on TB, Christoph Grundner urged the need to consider basic research as an essential component of any future anti-TB strategy.
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
Normal service will resume after Covid-19 crisis ends.
Normal service will resume after Covid-19 crisis ends.
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