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Epidemiology of preclinical systematic reviews

May 5, 2021

Epidemiology of preclinical systematic reviews

A cross sectional study of a sample of recent preclinical systematic reviews, by Victoria Hunniford, Manoj Lalu and co-authors, reveals deficiencies in reporting and provides the justification and evidence to inform the development of specific guidelines for conducting and reporting preclinical systematic reviews.

Image credit: pbio.3001177

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

05/06/2021

Methods and Resources

An update to Hippocampome.org

By integrating single-cell firing behavior during in vivo oscillations with morphological and molecular neuron classification in vitro, Alberto Sanchez-Aguilera, Diek Wheeler, Liset de la Prida, Giorgio Ascoli and colleagues standardize a framework for interpreting the functional roles of distinct circuit modules and ascribing extracellular recordings to identified neuron types.

Image credit: pbio.3001213

An update to Hippocampome.org

Recently Published Articles

Current Issue

Current Issue April 2021

05/05/2021

Research Article

Representing invisibility

Timo Stein, Simon van Gaal and co-workers show that the extent of unconscious information processing in human visual cortex is determined by the measurement approach; only subjectively, but not objectively, invisible stimuli are represented at a categorical level.

Image credit: pbio.3001241

Representing invisibility

05/04/2021

Essay

When is an oscillation not an oscillation?

Notions of how neural oscillations behave are as ubiquitous as their occurrence throughout the brain. But where do such notions come from? Using a normal form oscillator model, Keith Doelling and Florencia Assaneo refute a list of the most commonly held ideas of how an oscillator should behave and generate a series of cautionary examples to emphasize the findings.

Image credit: pbio.3001234

When is an oscillation not an oscillation?

05/04/2021

RESEARCh article

Triglyceride lipolysis protects a fly's "kidney"

Aleksandra Lubojemska, Alex Gould and co-authors use a high-fat diet model of chronic kidney disease in Drosophila to reveal that boosting triglyceride lipolysis in renal cells is sufficient to rescue renal cell function via a pathway involving PGC1 alpha and mitochondria.

Triglyceride lipolysis protects a fly's "kidney"

Image credit: A Lubojemska, A Yoshimura, L Collinson & AP Gould

05/04/2021

Essay

Cell-level metadata lacking in scRNA-seq studies

Most Gene Expression Omnibus (GEO) depositions of single-cell mRNA sequencing data do not include cell-level metadata generated by typical analysis pipelines; Sidhant Puntambekar, Kent Riemondy, Rui Fu and co-authors argue that this omission greatly hinders reproduction, exploration, validation, and knowledge transfer and is a common problem across journals, data repositories, and publication dates.

Cell-level metadata lacking in scRNA-seq studies

Image credit: pbio.3001077

05/03/2021

Perspective

Is GWAS no longer a paragon of open science?

Genomic research led the way in open science – a tradition continued by genome-wide association studies – through the sharing of materials, results and data. Coordinated quality control procedures also contributed to robust findings. But Callie Burt and Marcus Munafò wonder whether these standards are now slipping back...

Is GWAS no longer a paragon of open science?

Image credit: pbio.1001661

05/03/2021

Research Article

Encoding social behavior

Behaviorally-specific patterns of correlated activity between prefrontal neurons normally enhance the information that neuronal ensembles transmit about social behavior. In a mouse model of autism, this additional information carried by patterns of correlated activity is lost.

Encoding social behavior

Image credit: pbio.3001235

05/03/2021

Research article

Boosting translation

A cell-based screen identifies a small molecule, Y-320, that potently enhances readthrough of premature termination codons by the aminoglycoside G418. Y-320 increases cellular protein levels and protein synthesis, and appears to act via an autocrine chemokine signaling pathway.

Boosting translation

Image credit: pbio.3001221

04/29/2021

Research Article

A structural view of SARS-CoV-2 variant B.1.1.7

The cryo-EM structure of the N501Y mutant version of the SARS-CoV-2 spike protein in complex with its receptor ACE2 reveals the intermolecular interactions that may underlie the increasing prevalence of the B.1.1.7 SARS-CoV-2 variant.

A structural view of SARS-CoV-2 variant B.1.1.7

Image credit: pbio.3001237

04/29/2021

Research Article

Performance of SARS-CoV-2 lateral flow testing

An evaluation of the performance of SARS-CoV-2 antigen lateral flow devices, validated using PCR, concludes that they do not detect infections presenting with higher PCR Ct values, reinforcing the need for frequent, recurrent testing.

Performance of SARS-CoV-2 lateral flow testing

Image credit: Unsplash user Anne Spratt

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