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Taxane chemotherapy awakens dormant cancer cells

September 12, 2023

Taxane chemotherapy awakens dormant cancer cells

Ramya Ganesan, Vikas Sukhatme and colleagues use a tumor stromal organoid and murine breast cancer model to reveal that chemotherapy injures stromal cells; this stromal injury in turn invokes proinflammatory cytokine signaling and can awaken dormant cancer cells. Read the accompanying Primer by Tyler Cooper and Lynne-Marie Postovit.

Image credit: pbio.30022755

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

09/15/2023

Research Article

Gating the proton-activated chloride channel

The proton-activated chloride (PAC) channel plays a critical role in ischemic neuron death, but its activation mechanisms remain elusive. Piao Zhao, Cheng Tang, Yuqin Yang, Hao Dong, Rajesh Khanna, Zhonghua Liu and co-authors reveal the proton gating and protonation-independent voltage gating mechanisms of the PAC channel, with implications for drug development.

Image credit: pbio.3002309

Gating the proton-activated chloride channel

Recently Published Articles

Current Issue

Current Issue August 2023

09/15/2023

Research Article

Function of overlapping genes

Overlapping genes are widely prevalent but their expression and consequences are poorly understood. Bhavesh Parmar, Liesbet Temmerman and co-workers show that the C. elegans zyxin locus, zyx-1, contains a small open reading frame, azyx-1, which has a dual cis- and trans-acting role in regulating zyx-1 isoform diversity.

Image credit: pbio.3002300

Function of overlapping genes

09/14/2023

Short Reports

Tissue-specific resistance to protein aggregation during aging

Raimund Jung, Della David and colleagues show that, during failure of core protein quality control in C. elegans, a specialized anti-aggregation mechanism involving intracellular pathogen response factors and lysosome-mediated degradation is triggered, promoting tissue-specific resilience to age-dependent protein aggregation and its proteotoxic effects.

Image credit: pbio.3002284

Tissue-specific resistance to protein aggregation during aging

09/14/2023

Research Article

Novel signaling axis drives colorectal cancer

Jiaojiao Hao, Jinsheng Huang, Chunyu Hua, Yan Zuo, Wuguo Deng, Fei Lin, Wei Guo and co-worker reveal that a novel TOX3-WDR5-H3K4me3/ABCG2 signaling axis is upregulated in colorectal cancer (CRC) stem cells; targeting this pathway may help overcome the challenges of drug tolerance, recurrence and metastasis. Also read the Primer by Christopher Hubert, Shaun Stauffer and Justin Lathia.

Novel signaling axis drives colorectal cancer

Image credit: pbio.3002256

09/12/2023

Short Reports

Neighbors affect crop disease susceptibility

Susceptibility to pathogens is mitigated by the effects of diversity on epidemiological factors. This study of two major crops, by Rémi Pélissier, Jean-Benoit Morel and co-authors, shows that in the absence of epidemics, the mere growing of mixed plants from different genotypes can have stronger effects than intrinsic susceptibility levels, with implications for nature-based solutions for agriculture.

Neighbors affect crop disease susceptibility

Image credit: Unsplash user Andhika-Wiguna

09/12/2023

Methods and Resources

Seasonal transcription in plants

Daylength guides the timing of biological processes in plants, but a comprehensive view of the underlying transcriptional regulation is lacking. Chun Chung Leung, Daniel Tarté, Lilijana Oliver, Qingqing Wang and Joshua Gendron use time course RNA-seq to thoroughly examine gene expression of Arabidopsis plants in three photoperiods, revealing previously unexplored photoperiodic gene regulation.

Seasonal transcription in plants

Image credit: pbio.3002283

09/14/2023

Perspective

Supporting nonlinear careers

Those who follow non-linear career trajectories often face disadvantages in academia. This Perspective looks at why individuals might choose non-linear careers and how these benefit diversity in science.

Supporting nonlinear careers

Image credit: pbio.3002291

09/11/2023

Essay

Using evolutionary mismatch to explore disease

This Essay advocates combining genomic tools with partnerships with subsistence-level groups experiencing rapid lifestyle change to identify genetic loci associated with disease risk.

Using evolutionary mismatch to explore disease

Image credit: pbio.3002311

09/05/2023

Essay

What makes a successful research institute?

What are the features that make a research institute and its people flourish? This Essay explores the organization and culture of successful research institutes and looks at the lessons that can be learned from them.

What makes a successful research institute?

Image credit: pbio.3002267

08/29/2023

Perspective

Conserve wildlife to preserve tropical carbon

Loss of large-bodied wildlife degrades the processes in tropical forests that sequester carbon. This Perspective argues that carbon-based markets that incentivize wildlife conservation can support forest and hunting management.

Conserve wildlife to preserve tropical carbon

Image credit: John G. Robinson

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PLOS Biology | ISSN: 1545-7885 (online)