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Building a Trap

October 10, 2019

Building a Trap

Many plant and animal organs derive from tissue sheets, but how are they shaped to create the diversity of forms observed in nature? Karen Lee, Claire Bushell, Yohei Koide, Minlong Cui, Enrico Coen and co-workers use a combination of imaging and mathematical modelling to show how carnivorous plant traps shape themselves in 3D by a growth framework oriented by tissue polarity, similar to that found in planar leaves.

Image credit: Karen Lee, Yohei Koide, John Fozard, Claire Bushell

EDBC 2019 Alicante (Spain) 23th-26th October

European Developmental Biology Congress

European Developmental Biology Congress

10/10/2019

Meta-Research Article

Which Studies Will Translate to Health Interventions?

Fundamental scientific advances can take decades to translate into improvements in human health. Ian Hutchins, Matthew Davis, Rebecca Meseroll and George Santangelo show that a machine learning model can accurately predict whether an article is likely to be cited by a future clinical trial or guideline, using as little as two years of post-publication citation data. Also read the Community Page article that presents the NIH Open Citation Collection and iCite.

Image credit: pbio.3000416

Which Studies Will Translate to Health Interventions?

Recently Published Articles

Current Issue

Current Issue September 2019

10/10/2019

Research Article

Sex Chromosomes Control Pillbug's Symbionts

Microbial endosymbiosis is widespread in animals and relies on efficient vertical transmission through host generations. Thomas Becking, Clément Gilbert, Richard Cordaux and colleagues show that sex chromosomes control vertical transmission of feminizing Wolbachia endosymbionts in an isopod, offering a new perspective on the evolutionary interplay between microbial symbionts and host sex chromosomes.

Image credit: Flickr user Judy Gallagher

Sex Chromosomes Control Pillbug's Symbionts

10/10/2019

Research Article

The Crossroads of Protein & RNA Splicing

A structural study by Cathleen Green, Zhong Li, Hongmin Li, Marlene Belfort and co-authors shows that an intein interrupting the critical spliceosomal protein Prp8 in the fungal pathogen Cryptococcus neoformans is inhibited by biologically relevant metals, with implications for the regulation of RNA splicing.

Image credit: pbio.3000104

The Crossroads of Protein & RNA Splicing

10/07/2019

Methods and Resources

Skeletal Muscle Identity

The epigenomic basis for the identity and adaptation of different muscle groups is poorly understood. Krithika Ramachandran, Grant Barish and co-authors reveal chromatin landscapes across muscle groups and their dynamic response to either exercise or over-expression of PPAR gamma coactivator 1 alpha (PGC1α).

Skeletal Muscle Identity

Image credit: pbio.3000467

10/04/2019

Research Article

Toxo's Inner Membrane Complex

The inner membrane complex of the human parasite Toxoplasma gondii is an important organelle involved in motility and replication. Charles Choi, Peter Bradley and co-workers expand the genetic code of Toxoplasma, allowing the use of photoactivatable unnatural amino acids to uncover interactions within the apicomplexan inner membrane complex.

Toxo's Inner Membrane Complex

Image credit: pbio.3000475

10/10/2019

Research Article

Learning to Read

How a child’s brain develops specialization for print is poorly understood. A study of children learning to read Chinese, by Jing Zhao, Urs Maurer, Sheng He and Xuchu Weng, shows that neural specialization for print develops through and is characterized by interactions between regularities of visual inputs and efficiency of top-down predictions.

Learning to Read

Image credit: pbio.3000474

10/10/2019

Research Article

Evolution of Deformed Wing Virus

 A novel reverse-genetic system uses deformed wing virus, a pathogen of honey bees, to provide insights into the forces that shape virus diversity, suggesting that virus quasi-species diversification may be driven by selection to evade host RNAi defences.

Evolution of Deformed Wing Virus

Image credit: pbio.3000502

10/10/2019

Research Article

Regulating Cell Migration

Cells display a high degree of plasticity in migration, but how polarity is organized in different microenvironments has remained unclear. This study uses mechanical perturbations to reveal that migration using actin-rich or bleb-based protrusions are both organized around Rac GTPase.

Regulating Cell Migration

Image credit: pbio.3000457

10/07/2019

Research Article

Mating-Induced Switch in the Fly "Prostate"

Hormone receptor-dependent growth of secondary cells in the accessory glands of male fruit flies switches to a hormone-independent mechanism after mating, reminiscent of changes seen in advanced prostate cancer in humans.

Mating-Induced Switch in the Fly "Prostate"

Image credit: Aashika Sekar

10/09/2019

Research Article

Single-Cell Picture of Human Implantation

Single-cell RNA-seq of human peri-implantation conceptuses in vitro reveals TBX3 as a key regulator of trophoblast cell-fate divergence.

Single-Cell Picture of Human Implantation

Image credit: pbio.3000187

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