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Receptor on red blood cell prevents age-related decline

June 17, 2021

Receptor on red blood cell prevents age-related decline

Hypoxia drives aging and promotes age-related functional decline in cognition and hearing. Qingfen Qiang, Yang Xia and colleagues show that signaling through the erythrocyte adenosine A2B receptor promotes metabolic reprogramming, increased production of 2,3-bisphosphoglycerate and lower hypoxia-induced inflammatory responses in the hippocampus, cortex and cochlea during aging.

Image credit: Qingfen Qiang

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

06/18/2021

research article

SARS-CoV-2 antibody binding

Anna Heffron, Irene Ong and co-workers use profiling of antibody binding from naïve and COVID-19 convalescent human sera to the entire proteome of SARS-CoV-2 (and other human, bat and pangolin coronaviruses) to identify 79 B cell epitopes throughout the SARS-CoV-2 proteome, finding that the most sensitive and specific binding occurred in the membrane (M) protein, and revealing cross-reactivity patterns.

Image credit: pbio.3001265

SARS-CoV-2 antibody binding

Recently Published Articles

Current Issue

Current Issue May 2021

06/17/2021

ESSAY

Pandemic testing strategies

COVID-19 testing programs are very important to help control the pandemic. James Nichols, Tiffany Bogich, Katriona Shea and co-authors show that objective-driven, strategic sampling designs and analytics can be used to maximize the information gained by COVID-19 testing programs and improve population-level decisions, while maintaining the value of these programs for patient-level management.

Image credit: pbio.3001307

Pandemic testing strategies

06/17/2021

Methods and Resources

The archaeal glycoproteome

A comprehensive glycoproteomic analysis of Haloferax volcanii, by Stefan Schulze, Mechthild Pohlschroder ad colleagues, reveals the extent and complexity of glycosylation in archaea and provides new insights into the roles of this post-translational modification in various cellular processes, including cell shape determination.

Image credit: pbio.3001277

The archaeal glycoproteome

06/17/2021

Research Article

Explaining social organization

Yuko Ulrich, Mari Kawakatsu, Corina Tarnita, Daniel Kronauer and co-workers use automated tracking of clonal raider ants and mathematical modeling to reveal how traits of larvae and workers shape social organization in heterogeneous ant colonies. Incorporating the potential for variability in adult task efficiency and larval task demand allow the authors to account for all empirically observed phenomena.

Explaining social organization

Image credit: Daniel Kronauer

06/16/2021

research article

Interpreting guinea pig calls

Pilar Montes-Lourido, Manaswini Kar, Stephen David and Srivatsun Sadagopan study the neuronal representations elicited in guinea pigs by conspecific calls at different auditory processing stages, revealing insights into where call-selective neuronal responses emerge; the transformation from nonselective to call-selective responses occurs in the superficial layers of the primary auditory cortex.

Interpreting guinea pig calls

Image credit: pbio.3001299

06/15/2021

Essay

Dismantling a discriminatory reward system

Sarah Davies, Hollie Putnam, Amanda Bates and co-authors argue that success and impact metrics in science are based on a system that perpetuates sexist and racist ‘rewards’ by prioritizing citations and impact factors; the authors advocate shifting this outdated value system to advance science through principles of justice, equity, diversity, and inclusion.

Dismantling a discriminatory reward system

Image credit: pbio.3001282

06/15/2021

Meta-Research Article

Invisible mice

When scientists neglect to say that research findings were obtained using mice, the media tend to replicate the trend by omitting the use of mice from news headlines that report on these papers, thereby perpetuating the omission.

Invisible mice

Image credit: Sibya (Pixabay), Elnur (iStock) & rez2graphics (Fiverr)

06/14/2021

Research Article

Learning new words

A combined neuroimaging and brain stimulation study reveals rapid and distributed microstructural plasticity after a single language learning session, demonstrating the causal relevance of the motor cortex in encoding the meaning of novel action words.

Learning new words

Image credit: pbio.3001290

06/10/2021

Research Article

LncRNA maintains cerebellar synapses

LncRNA-PM activates transcription of the cerebellar synaptic organizer Cbln1 by promoting Pax6-Mll1-mediated H3K4me3 methylation, thereby helping to maintain cerebellar synaptic integrity and motor function.

LncRNA maintains cerebellar synapses

Image credit: Yan Jin, Bowen Zhang & Xiangting Wang

06/10/2021

Research Article

Setting the speed of muscles

Heart and skeletal muscles of larger mammals contract more slowly than smaller ones. This study identifies amino acid substitutions in human β-myosin that can increase its in vitro velocity to that of the rat protein.

Setting the speed of muscles

Image credit: pbio.3001248

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