08/28/2018
research article
Sander Govers, Abram Aertsen and co-workers show that protein aggregates in Escherichia coli tend to emerge in response to sub-lethal proteotoxic exposures, after which these asymmetrically inherited structures serve as stress-induced, epigenetic memory that protects their carrier cells against subsequent proteotoxic stress.
Image credit: pbio.2003853
Current Issue August 2018
08/27/2018
research article
Bryce Mendelsohn, Ken Nakamura and co-authors use a FRET-based high-throughput screen that measures ATPs levels in individual mammalian cells to identify genes that regulate ATP level, as well as genetic defects that are responsive to energy-based therapies such as coenzyme Q10 supplementation.
Image credit: pbio.2004624
08/28/2018
Community Page
Nicolas Fiorini, Zhiyong Lu and co-authors present Best Match, a new relevance search algorithm for PubMed that allows readers to use machine learning to find articles that best match their needs.
Image credit: Flickr user: dullhunk
08/29/2018
methods and resources
HIV-1 envelope protein is covered with unusual polysaccharides not normally produced by eukaryotic cells. Antibodies against the virus often require these sugars, potentially compromising manufacture of vaccine antigens, but Gabriel Byrne, Phillip Berman and colleagues' CRISPR-engineered high-mannose CHO cell line may offer a solution.
Image credit: pbio.2005817
08/29/2018
research article
Ayaz Najafov, Junying Yuan and co-workers use cell-based high-throughput screening and bioinformatics to identify BRAF and AXL as oncogenes that drive escape from necroptosis by reducing RIPK3 expression; sensitivity to necroptosis can be restored by targeting the oncogenes with drugs.
Image credit: PDB
08/31/2018
perspective
Craig Packer and Stephen Polasky propose that allocation of scarce conservation funding should consider the possibility that high-profile wildlife areas not only hold significant biodiversity value but may also be most vulnerable to leakage from local corruption.
Image credit: Flickr user: lhanaphotography
08/31/2018
research article
Overexpression of leptin in transgenic pigs results in a phenotype bearing a remarkable resemblance to human systemic lupus erythromatosus (SLE), sharing multiple aspects of the disease.
Image credit: pbio.2005354
08/28/2018
research article
Subnetworks segregated along the proximodistal axis of hippocampal CA1 and CA3 preferentially process spatial or non-spatial information.
Image credit: pbio.2006100
08/29/2018
Primer
This Primer explores the implications of a new study that takes a significant step closer to understanding how information is maintained in mind by providing evidence for phase-coding in the human brain.
Image credit: pbio.2003805
08/21/2018
research article
Delayed emergence of drug-resistant malaria in sub-Saharan Africa may be caused by within-host competition between drug-sensitive and drug-resistant parasites.
Image credit: nuzree, Pixabay
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
Rodrigo Almeida argues that considering the social context of emerging plant diseases and effective science communication are essential for the management epidemics.
Oswald Schmitz suggests that studying how species produce ecological functions can be like watching jazz musicians improvise as they respond and adapt to one another to create their music.
Meta-research may not be as click-worthy as a meta-pug – a pug dog dressed up in a pug costume – but it is crucial to understanding research, says Lisa Bero in this Research Matters article.
John Ioannidis explores the study of research itself: its methods, reporting, reproducibility, evaluation, and incentives.
How resistance arises at the cellular level, how it evolves and spreads, and how we can combat it.
How animals combine information from the outside world and from within their own bodies to decide what they should eat.
How the engulfment of a small bacterium by a larger archaeon more than a billion years ago resulted not in death, but in one of the most successful partnerships on earth.
The composition and function of microbiomes are critical for most animals and plants; how do relationships between hosts and microbes evolve over time?
Medics have long recognised the curious power of the placebo. What is known of its biological basis and the complex ethical and practical issues that surround it?
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