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Tasting Sex with your Wing

May 21, 2019

Tasting Sex with your Wing

The Drosophila wing is a taste organ, but this aspect of its function has been neglected. Molecular analysis of the wing, by Zhe He, Yichen Luo, John Carlson and colleagues, identifies a candidate ionotropic pheromone receptor that regulates the fly’s sexual circuitry.

Image credit: pbio.2006619

Celebrate our 15th Anniversary! Tweet @PLOSBiology #PLOSBIO15

PLOS Biology's XV Collection

05/21/2019

Research Article

A New Target for Rapamycin 

The protein kinase mTOR is believed to mediate most of the effects of the drug rapamycin, but Xiaoli Zhang, Wei Chen, Benfang Ruan, Haoxing Xu and co-authors identify MCOLN1, a lysosome-localized calcium channel that plays essential roles in autophagy and lysosome function, as a novel molecular target of rapamycin.


Image credit: pbio.3000252

A New Target for Rapamycin 

Recently Published Articles

Current Issue

Current Issue April 2019

05/17/2019

Methods and Resources

Shunting Organelles at Will

Carlos Guardia, Juan Bonifacino and co-workers show that reversibly coupling intracellular organelles to microtubule motors, using streptavidin-biotin chemistry, enables the analysis of the relationship between organelle positioning and function.


Image credit: pbio.3000279

Shunting Organelles at Will

05/21/2019

Research Article

Life in the Fast Lane

Jacob Steenwyk, Chris Todd Hittinger, Antonis Rokas and colleagues show that a lineage in the budding yeast genus Hanseniaspora has remarkably high evolutionary rates, low GC content, small genome sizes, and lower gene numbers than the rest of the subphylum. Analysis of 25 genomes reveals that this lineage has survived and diversified for tens of millions of years despite lacking dozens of cell cycle and DNA repair genes normally thought to be essential.


Image credit: pbio.3000255

Life in the Fast Lane

05/21/2019

Community Page

Centrifuges for Everyone!

Gaurav Byagathvalli, Aaron Pomerantz, Soham Sinha, Janet Standeven, and Saad Bhamla describe a low-cost 3D-printed centrifuge to enable sequencing in remote field conditions and lowering the barrier to synthetic biology research in high schools to broaden participation in hands-on STEM.

Centrifuges for Everyone!

Image credit: Aaron Pomerantz, M. Saad Bhamla

05/20/2019

Meta-Research Article

Chemotherapy-Induced Neuropathy

This systematic review by Gillian Currie, Andrew Rice, Emily Sena and colleagues assesses limitations in the experimental design of studies modelling peripheral neuropathy induced by chemotherapy. The data allow the authors to provide guidance on experimental design to improve the robustness and validity of future studies.


Chemotherapy-Induced Neuropathy

Image credit: pone.0170814

05/20/2019

Research Article

Switching Histones

The variant histone H2A.Z is essential for the viability of metazoans. The structure of H2A.Z-H2B histone dimer in complex with the chaperone Chz1, by Yunyun Wang, Zheng Zhou and co-workers, reveals the basis of Chz1’s specificity for recognising H2A.Z. In vitro studies show that Chz1 facilitates H2A.Z deposition by relieving the inhibitory effects of excess free histone dimers.


Switching Histones

Image credit: pbio.3000277

05/21/2019

Community Page

Rxivist.org: Sorting Biology Preprints

Richard Abdill and Ran Blekhman describe Rxivist.org, a new website that indexes all bioRxiv preprints and allows users to filter and sort papers based on download metrics and Twitter activity.


Rxivist.org: Sorting Biology Preprints

Image credit: Rxivist screenshot

05/22/2019

Editorial

Contextualising Peer Review & Publication

Our experiment with contextualised publication, whereby potentially controversial studies are published with a Primer in which the Academic Editor guides the reader, dissects the study, and lays out the thinking behind the decision to publish.

Contextualising Peer Review & Publication

Image credit: Anna Miska-Alvarez

05/20/2019

Research Article

Microstructural Gradients in the Cortex

Modelling cortico-cortical networks of microstructural similarity reveals consistent gradients of microstructural differentiation running from sensory to transmodal cortices, and allows single-subject investigation of structure-function correspondence.


Microstructural Gradients in the Cortex

Image credit: pbio.3000284

05/23/2019

Research Article

Balancing Mortality and Immortality

Bacterial lineages maintain replicative immortality by reaching an equilibrium between aging and rejuvenation; when this equilibrium is disrupted, aging lineages cross their immortality threshold, becoming mortal.


Balancing Mortality and Immortality

Image credit: Flickr NIAID

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