06/30/2020
Research Article
María Gutiérrez-Salmerón, José Manuel García-Martínez, Ana Chocarro-Calvo, Custodia García-Jiménez and colleagues show that metabolic context determines whether the key energy sensor AMPK is a tumor suppressor or tumor promoter. This paradoxical behavior is explained through glucose inhibition of AMPK in healthy tissue versus glucose induction of AMPK in colon cancer epithelial cells.
Image credit: pbio.3000732
Current Issue June 2020
06/29/2020
Research Article
How do we represent items held at different levels of priority in visual working memory (“prioritized” vs “unprioritized”)? Qing Yu, Chunyue Teng, and Bradley Postle provide evidence that a common remapping operation may be engaged (selectively in the regions primarily responsible for representing feature-level information) when information held in working memory is outside the focus of attention.
Image credit: Wikimedia Commons user Murgatroyd49
06/25/2020
Research Article
Penelope Hancock, Catherine Moyes and co-workers provide fine-resolution maps of insecticide resistance levels in malaria vectors for large parts of Sub-Saharan Africa; these quantify recent spatial trends and can inform implementation of management practices.
Image credit: pbio.3000633
06/25/2020
Research Article
Inflammation and infection can trigger local tissue accumulation of Na+ ions, boosting pro-inflammatory antimicrobial activity of monocyte/macrophage-like cells. Patrick Neubert, Arne Homann, David Wendelborn, Jonathan Jantsch and colleagues show that the sensing of Na+ ions by macrophages requires the Na+/Ca2+ exchanger NCX1.
Image credit: pbio.3000722
06/19/2020
Research Article
Curli are functional amyloids that play critical roles in biofilm formation and adhesion in many Enterobacteriaceae. Two outer membrane proteins, CsgG and CsgF, form the core apparatus for secretion and assembly of the curli structural subunits. The cryo-EM structure of the CsgG-CsgF complex, by Manfeng Zhang, Huigang Shi, Xuemei Zhang, Xinzheng Zhang and Yihua Huang, reveals a unique amyloid secretion channel with two tandem constriction regions.
Image credit: pbio.3000748
06/19/2020
Research Article
Information about unexpected stimuli is encoded in the form of prediction error signals. The earliest prediction error signals identified in the auditory brain emerge subcortically in the inferior colliculus. Catalina Valdés-Baizabal, Guillermo Carbajal, David Pérez-González and Manuel Malmierca reveal the essential role of dopamine in encoding the precision of prediction errors at the auditory midbrain.
Image credit: pbio.3000744
06/18/2020
Short Reports
Redistributing centriolar satellites to the periphery or center of the cell reveals novel functions for satellites during mitosis, cilium maintenance, and cilium disassembly, suggesting novel mechanisms.
Image credit: pbio.3000679
06/12/2020
Short Report & PRIMER
Why do we like seeing good things happen to others? A study of rhesus monkeys playing a juice donation game shows that the anterior cingulate cortex is necessary for monkeys to acquire normal prosocial preferences. Also read the accompanying Primer.
Image credit: pbio.3000735
06/10/2020
Methods and Resources
Developmental progression of Trypanosoma brucei is accompanied by metabolic remodeling of its mitochondrion, increasing levels of ROS, which act as essential signals to drive differentiation.
Image credit: pbio.3000741
06/10/2020
Research Article
Tumor-infiltrating macrophages have an active UPR and a mixed proinflammatory and immune-suppressive phenotype. This is driven by the IRE1a/Xbp1 axis of the UPR, so targeting the UPR may increase the response to immune checkpoint blockade therapy.
Image credit: Flickr user NIAID
Raquel Lieberman discusses her work on the protein myocilin, implicated in glaucoma, but whose normal function remains unclear after over 20 years.
Susanna Bidgood explores the future of using poxviruses as versatile tools for cell biology research.
Rachel Harding proposes that open notebooks present an opportunity for researchers to showcase their work and rapidly advance science in their field
On the eve of the UN General Assembly meeting on TB, Christoph Grundner urged the need to consider basic research as an essential component of any future anti-TB strategy.
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
Normal service will resume after Covid-19 crisis ends.
Normal service will resume after Covid-19 crisis ends.
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