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Amyloid from the liver can cause Alzheimer's disease

September 14, 2021

Amyloid from the liver can cause Alzheimer's disease

It has been suggested that peripheral metabolism of amyloid-beta is associated with risk for Alzheimer’s disease. Virginie Lam, Ryusuke Takechi, John Mamo and co-workers reveal that the expression of human amyloid exclusively in the liver induces Alzheimer's disease-like pathologies in mice, potentially indicating a completely novel pathway of Alzheimer's disease aetiology and therapies. Also read the accompanying Primer.

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PLOS Biologue

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PLOS BIOLOGUE

09/17/2021

Primer

Parasite effectors target NLRs in plants

For successful colonization, parasites need to target the plant immune system. This Primer by Yuanyuan Li, Nathan Meier and Savithramma Dinesh-Kumar explores a new study in PLOS Biology which reveals that unrelated parasites have evolved effectors which specifically suppress the function of helper NLRs, explaining the complex dynamics of plant-parasite coevolution. Read the related Research Article.

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Parasite effectors target NLRs in plants

Recently Published Articles

Current Issue

Current Issue August 2021

09/16/2021

Research Article

Complexity of the Purkinje cell

Purkinje cell (PC) discharge, the only output of cerebellar cortex, involves both high-frequency simple spikes and low-frequency complex spikes; the function of the latter, determined by a PC's climbing fibre input, remains controversial. Akshay Markanday, Peter Thier and co-authors show that PCs receive a multiplexed climbing fibre input that merges complementary streams of information relevant for behaviour.

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Complexity of the Purkinje cell

09/16/2021

Research Article

Sparse spiking and navigation

This study of active navigation by Jai Yu and Loren Frank shows that, rather than being local noise within the hippocampus, sparse, isolated place cell spiking reflects a coordinated cortical-hippocampal process consistent with the generation of non-local scenario representations.

Image credit: pbio.3001393

Sparse spiking and navigation

09/14/2021

Short Reports

Microplastics in lakes

Pollution from microplastics and anthropogenic fibres threatens lakes, but we know little about what factors determine its accumulation. Andrew Tanentzap, Laurent Lebreton and colleagues use a survey of 67 European lakes spanning 30° of latitude to show that economic and environmental indicators predict the pollution of lakes by anthropogenic microparticles.

Microplastics in lakes

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09/09/2021

Community Page

Preregistration of animal studies: how's it going?

Mira van der Naald, Kimberley Wever and co-authors present a 3-year evaluation of the first platform dedicated to preregistration of animal studies, www.preclinicaltrials.eu, and comparable platforms, encouraging the scientific community to embrace preregistration in a move towards more effective animal research.

Preregistration of animal studies: how's it going?

Image credit: pbio.3001397

09/09/2021

Research Article

Herpesvirus 8 tricks its way in

Herpesviruses are known to hijack cellular receptors to enter cells, but Taylor Light, Kalina Hristova, Marija Backovic and co-authors show that human herpesvirus 8 takes this to another level by using its envelope glycoprotein complex gH/gL to mimic the EphA2 receptor's natural ligands, ephrins.

Herpesvirus 8 tricks its way in

Image credit: pbio.3001392

09/09/2021

Research Article

How Plasmodium dumps lactate

The malaria parasite's lactate transporter, PfFNT, is a potential drug target due to its housekeeping role in lactate efflux. Cryo-EM structures of PfFNT alone or with an anti-malarial drug reveal the mechanism of lactate transport and drug inhibition.

How Plasmodium dumps lactate

Image credit: pbio.3001386

09/09/2021

Methods and Resources

Tracking blood in single vessels

A phase contrast-based, high field MRI-based approach for the functional mapping of cerebral blood velocity in individual cortical arterioles and venules in the rat cortex.

Tracking blood in single vessels

Image credit: pbio.3000923

09/08/2021

Research Article

What triggers preterm labor?

Preterm labor is driven by upregulation of specific pathways involved in augmentation of inflammation, by invasion of neutrophils in the amnion layer of the fetal membranes, and by production of specific inflammatory mediators.

What triggers preterm labor?

Image credit: pbio.3001385

09/07/2021

Research Article

Embryonic epigenetics vs cell proliferation

Inhibition of cell proliferation in Xenopus embryos is largely compatible with embryo survival and cellular differentiation but results in an excess of repressive histone marks. On release from cell cycle block, embryos revert towards normality.

Embryonic epigenetics vs cell proliferation

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