09/15/2023
Research Article
Gating the proton-activated chloride channel
The proton-activated chloride (PAC) channel plays a critical role in ischemic neuron death, but its activation mechanisms remain elusive. Piao Zhao, Cheng Tang, Yuqin Yang, Hao Dong, Rajesh Khanna, Zhonghua Liu and co-authors reveal the proton gating and protonation-independent voltage gating mechanisms of the PAC channel, with implications for drug development.
Image credit: pbio.3002309
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