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Predicting genome evolution

August 26, 2024

Predicting genome evolution

Quinn Langdon, Molly Schumer and co-authors use hybrid populations of swordtail fish to reveal high repeatability in the genome due to strong selection in the earliest generations after initial hybridization.


Image credit: pbio.3002742

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

08/29/2024

Research Article

How many marine fish species are at risk of extinction?

Empirical data on occurrences and vulnerability are still lacking for most marine teleost fish species. Nicolas Loiseau, Nicolas Mouquet and colleagues use machine learning with occurrence data, species biological traits, taxonomy and human usage to infer a 12.8% extinction risk for marine fish species, surpassing existing estimates.

Image credit: pbio.3002773

How many marine fish species are at risk of extinction?

Recently Published Articles

Current Issue

Current Issue August 2024

08/29/2024

Research Article

Why do spiders have a small waist?

The chelicerate body plan is unique among arthropods because segments are divided into two tagmata – cephalothorax and abdomen – but the mechanisms that establish the boundary between them remain unclear. Emily Setton, Prashant Sharma and co-workers identify a new gene named waist-less that is required for patterning the spider body plan.

Image credit: pbio.3002771

Why do spiders have a small waist?

08/27/2024

Short Reports

Bemnifosbuvir pathway at atomic resolution

Bemnifosbuvir (AT-527) and AT-752 are broad-spectrum antiviral guanosine analogues currently in clinical trials. Aurélie Chazot, François Ferron, Bruno Canard and colleagues reconstitute their intracellular 5-step enzymatic activation pathway, characterizing each enzymatic complex at atomic resolution, which provides insight into substrate binding and drug activation.

Image credit: pbio.3002743

Bemnifosbuvir pathway at atomic resolution

08/26/2024

Research Article

Keeping nuclear reassembly in check

How cells respond to defects in nuclear reassembly after mitosis? Jingjing Li, Vincent Archambault and co-authors show that damaged cells in Drosophila are either removed by apoptosis or activate a p53-dependent cell cycle checkpoint to maintain tissue integrity.

Keeping nuclear reassembly in check

Image credit: pbio.3002780

08/26/2024

Research Article

The art of smell: fast-spiking interneuron detonation

Inhibitory circuits in the mammalian olfactory bulb shape information as it propagates from peripheral receptors to the downstream cortex. Shawn Burton, Christina Malyshko and Nathaniel Urban show that fast-spiking interneurons perisomatically inhibit projection neurons in the mammalian olfactory bulb via synaptic detonation.

The art of smell: fast-spiking interneuron detonation

Image credit: pbio.3002660

08/23/2024

Research Article

Apical constriction promotes germ cell apoptosis

Germ cell apoptosis in C. elegans hermaphrodites eliminates around 60% of all cells in meiotic prophase to maintain tissue homeostasis. Tea Kohlbrenner, Alex Hajnal and colleagues show that the size of meiotic germ cells is reduced by apical actomyosin constriction, which triggers apoptosis in the C. elegans germline.

Apical constriction promotes germ cell apoptosis

Image credit: pbio.3002775

08/29/2024

Unsolved Mystery

Hijackers, hitchhikers, or co-drivers?

Manuel Ares-Arroyo, Charles Coluzzi, Jorge Moura de Sousa and Eduardo Rocha explore how microbial evolution is shaped by mobile genetic elements regulating each other. These functional dependencies raise numerous questions.

Hijackers, hitchhikers, or co-drivers?

Image credit: pbio.3002796

08/29/2024

Essay

Social media and online data to study animal behavior

Following Niko Tinbergen’s roadmap for behavioral investigation, Reut Vardi, Valerio Sbragaglia and colleagues show how using videos, photos, text, and audio posted online can shed new light on known behaviors and lead to the discovery of new ones.

Social media and online data to study animal behavior

Image credit: pbio.3002793

08/26/2024

Community Page

GetGenome: go genomics!

James Canham, Joe Win, Sophien Kamoun and colleagues introduce GetGenome, a non-profit organization that aims to  provide global and affordable access to genomics technology and training.

GetGenome: go genomics!

Image credit: pbio.3002804

08/26/2024

Perspective

Molecular connectomics: cells and tissues

Stathis Megas, Sarah Teichmann and co-authors link molecular and morphological cell features in three dimensions across scales, using machine learning and artificial intelligence to reveal emergent properties of complex biological systems.

Molecular connectomics: cells and tissues

Image credit: pbio.3002803

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