October 18, 2022
Image credit: NOAA, Alliance for the Chesapeake Bay, Bob Murphy
10/21/2022
Methods and Resources
Interactions between the molecular chaperone Hsp70 and its client proteins are critical for cellular viability and the response to stress. This proteomics study by Nitika, Andrew Truman and co-workers uses cross-linking mass spectrometry to identify novel direct interactors of Hsp70 in yeast and suggests that post-translational modifications play an important role in these interactions.
Image credit: pbio.3001839
Current Issue September 2022
10/21/2022
Meta-Research Article
The phenotype of an organism results not only from its genotype but also the influence of its environment throughout development. Ivana Jaric, Hanno Würbel and colleagues show that common environmental differences between animal facilities can induce substantial variation in the phenotype of mice, thereby highlighting an important limitation of inferences from single-laboratory studies in animal research.
Image credit: pbio.3001837
10/21/2022
Research Article
The nuclear basket is an essential structure of the nuclear pore complex and serves as a dynamic and multi-functional platform. Yu Tang, Yangnan Gu and co-authors reveal the guanylate-binding protein GBPL3 as a critical factor that joins the nuclear pore complex and the underlying nucleoskeleton, potentially creating a molecular hub for gene expression regulation during plant development and stress responses.
Image credit: pbio.3001831
10/21/2022
Research Article
Demetrios Neophytou, Diego Arribas, Hysell Oviedo and colleagues use the mouse as a model system that captures relevant features of human lateralized processing of speech and music, revealing a novel mechanism whereby stronger recurrent activity in the right auditory cortex led to longer temporal integration compared to the left (consistent with the temporal scales of syllabic and supra-syllabic processing).
Image credit: pbio.3001803
10/18/2022
Research Article
Human endogenous retrovirus (HERV) transcripts are known to be highly expressed in cancers, but what is their activity in normal tissue? Aidan Burn, John Coffin and co-workers use unique patterns of HERV-K RNA expression in the large GTEx dataset from non-diseased tissue sites to provide new insights into both the coevolution of HERV-K with our primate ancestors and their current role in human biology.
Image credit: pbio.3001826
10/13/2022
Methods and Resources
Molecular evolution studies often rely on single-copy orthologs. Jacob Steenwyk, Antonis Rokas and co-authors present OrthoSNAP, an algorithm that identifies and extracts additional single-copy orthologs nested within larger gene families; OrthoSNAP greatly increases the number of orthologs available for downstream molecular evolution analyses, while retaining phylogenetic information content.
Image credit: pbio.3001827
10/13/2022
Research Article
Lipoproteins in Gram-negative bacteria are sorted to the outer membrane via the Lol export pathway. This study provides a structural basis for LolCDE-mediated lipoprotein sorting, with implications for novel antibiotic design against Gram-negative pathogens.
Image credit: pbio.3001823
10/13/2022
Research Article
This modeling study shows that differences in the costs of hybridization to each sex can undermine the process of reinforcement; this sexual conflict over hybridization results in the transient evolution of reinforcement.
Image credit: pbio.3001814
10/13/2022
Research Article
The human LRRC15 protein is expressed in pathological fibroblasts, directly binds to the spike protein receptor binding domain, and inhibits SARS-CoV-2 spike-mediated viral entry in neighboring cells.
Image credit: pbio.3001805
10/13/2022
Methods and Resources
A circadian transcriptomic time-course dataset in wheat reveals the balance of circadian expression in a complex polyploid crop. Also read the accompanying Primer.
Image credit: pbio.3001802 credit Hannah Rees
This collection explores potential solutions to mitigate the impacts of human activity on ocean ecosystems to minimize or reverse degradation.
To mark 200 years since the birth of Gregor Mendel, this collection looks back at the impact of his original research and asks how well it stands up to modern views on genetics.
Nearly 50 years after researchers first found specks of plastic floating in the Atlantic Ocean, microplastics are everywhere. This collection contains evidence-based commentaries on the diverse impacts of microplastics.
How will global climate change affect the dynamics and distribution of pathogens and their plant and animal hosts? This collection features four papers that attempt to unravel some of the underlying complexity.
October 24 - 26
Meet Senior Editor Paula Jauregui
October 31 - November 1
Meet Senior Editor Paula Jauregui
November 16 - 18
Meet Associate Editor Luke Smith
November 30 - December 2
Meet Senior Editor Roli Roberts
Connect with Us