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Life and death of cold-water corals

May 19, 2022

Life and death of cold-water corals

A synthesis of six paleoceanographic reconstructions by Rodrigo Portilho-Ramos, Dierk Hebbeln and co-workers reveals that food supply and oxygen concentration had the strongest impact on cold-water coral vitality during the past 20,000 years.


Image credit: Marum Rov Cherokee

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

05/20/2022

Research Article

Targeting morphogen receptors

Receptor-ligand interactions can be restricted by different spatial distributions of the two interacting components, giving rise to an underappreciated layer of regulatory complexity. Aidan Peterson, Michael O’Connor and co-workers reveal that an evolutionarily conserved mechanism for polarized delivery of a transmembrane receptor supports robust morphogen signaling in a model epithelial tissue, the Drosophila wing disc.

Image credit: pbio.3001660

Targeting morphogen receptors

Recently Published Articles

Current Issue

Current IssueApril 2022

05/20/2022

Community Page

Open-source PPE for low-income settings

Free and open-source hardware, 3D printing and the use of locally sourced materials are valuable tools for local problem solving. Royhaan Folarin, Ahmed Adebowale Adedeji, Andre Maia Chagas and co-authors describe how PPE supply chain problems could be bypassed using open science in a Nigerian community.

Image credit: pbio.3001658

Open-source PPE for low-income settings

05/20/2022

Discovery Report

Two-step stochastic cell state switching

Switching between cell states can occur stochastically in a small subset of cells of an isogenic population in a seemingly homogenous environment. Naomi Ziv, Lucas Brenes and Alexander Johnson use direct observation of rare and stochastic cell-fate switching in Candida albicans to provide insights into the mechanism underlying stochastic switching.

Image credit: pbio.3001657

Two-step stochastic cell state switching

05/20/2022

Research Article

Single-neuron insulin response

Metabolic homeostasis is coordinated through a robust network of signaling pathways acting across all tissues. Ava Handley, Roger Pocock and colleagues show that C. elegans nematodes fed excess dietary glucose reduce the expression of insulin-1 specifically in the BAG glutamatergic sensory neurons, and that insulin-1 produced by these neurons systemically inhibits fat storage via the insulin-like receptor DAF-2.

Single-neuron insulin response

Image credit: pbio.3001655

05/18/2022

Research Article

Fatty acids and skin pigmentation

Temporal transcriptomic and metabolomic analysis of melanogenesis, by Farina Sultan, Vivek Natarajan, Rajesh Gokhale and co-authors, reveals fatty acid metabolism as a crucial mediator of the transition between pigmentation phases; inhibitors of the fatty acid pathway could represent a new target for modulating pigmentation.

Fatty acids and skin pigmentation

Image credit: Farina Sultan

05/17/2022

Discovery Report

Lipid peroxidation detox

How do double-membraned Gram-negative bacteria overcome lipid peroxidation stress? Marwa Naguib, Nicolás Feldman, Miguel Valvano and colleagues show that a periplasmic lipocalin, a membrane cytochrome b561, and a cytoplasmic aldehyde reductase are components of a novel evolutionarily conserved peroxidation detoxification system for lipid peroxyl radicals.

Lipid peroxidation detox

Image credit: pbio.3001610

05/17/2022

Research Article

Metacommunities in the Ediacaran period

The eco-evolutionary dynamics of metazoan diversification known from the Cambrian Period started earlier in the Ediacaran Period, culminating in the “Cambrian Explosion."

Metacommunities in the Ediacaran period

Image credit: Rebecca Eden

05/16/2022

Unsolved Mystery

Why do some coronaviruses “go viral”?

What does it take for a coronavirus to become a pandemic threat? And why has MERS-CoV repeatedly failed to emerge as a pandemic pathogen when SARS-CoV-2 has successfully spread around the world?

Why do some coronaviruses “go viral”?

Image credit: pbio.3001652

05/16/2022

Methods and Resources

PTMs in a structural context

A combination of AlphaFold2 structural predictions and large-scale post-translational modification (PTM) proteomics data sheds light on the functional importance of PTMs.

PTMs in a structural context

Image credit: pbio.3001636

05/13/2022

Research Article

Metacognition versus mentalizing

Both metacognition and mentalizing are associated with meta-representations. Application of a metacognition task to mentalizing reveals differences in neural representations of decision uncertainty. Also see the related Primer.

Metacognition versus mentalizing

Image credit: pbio.3001301

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PLOS Biology | ISSN: 1545-7885 (online)