01/17/2019
Research Article
Wenxin Song, Qi Luo, Kathleen Giacomini, Ligong Chen and co-workers find that white adipocytes use the organic cation transporter Oct3 for the uptake and subsequent degradation of norepinephrine, a major regulator of thermogenesis; Oct3-deficient mice show increased browning of white fat, dependent on adrenergic signaling.
Image credit: pbio.2006571
Current Issue December 2018
01/16/2019
Research Article
Branislav Ivan, Zhaozhi Sun, Harini Subbaraman, Nikolas Friedrich and Alexandra Trkola use comprehensive mapping of conformational stages adopted by the HIV‐1 envelope glycoprotein trimer during entry into the cell to reveal the preference of broadly neutralizing antibodies for distinct pre-fusion states of the trimer.
Image credit: RCSB PDB
01/15/2019
Perspective
William Ripple, Sterling Miller, John Schoen, and Sanford Rabinowitch argue that current large carnivore management in Alaska is a reversion to short-sighted and discredited concepts of the past, and occurs without monitoring programs designed to scientifically evaluate the impacts on predator populations.
Image credit: J.W. Schoen
01/14/2019
RESEARCH ARTICLE
A combination of experimentation and biophysical modeling, by Hervé Rabillé, Bernard Billoud, Bénédicte Charrier and colleagues, shows that tip growth in the brown alga Ectocarpus relies on a gradient of cell wall thickness, and not on a gradient of cell wall mechanical properties.
Image credit: Pierre-Louis Crouan & Hippolyte-Marie Crouan
01/15/2019
Methods & Resources
Rocío Canals, Jay Hinton and co-workers use comparative transcriptomic analysis of two contrasting Salmonella enterica Typhimurium isolates across 16 in vitro conditions and within macrophages to reveal the mechanism of African Salmonella metabolic defect and a novel bacterial plasmid maintenance system.
Image credit: NIAID
01/11/2019
essay
African sleeping sickness is an important disease of sub-Saharan Africa that is approaching elimination, Paul Capewell, Bruno Bucheton, Annette MacLeod and co-authors maintain that an overlooked anatomical reservoir — human skin — may impact control efforts.
Image credit: Mark Field
01/08/2019
Research Article
An RNAi functional screen of 40 Aedes aegypti genes specific to the mosquito lineage identifies EOF1 as a protein that plays an essential role in mosquito eggshell formation and melanization.
Image credit: James Gathany, Wikimedia
01/10/2019
Community Page
An open-source nucleic acid purification and handling protocols based on functionalised magnetic beads, with the aim of transforming life science research practice and its economics.
Image credit: pbio.3000107
01/10/2019
research article
Maternal sex pheromones in the wax layer of the fruit fly eggshell prevent the egg from leaking, and conceal it from predation by same-species larvae in an anti-cannibalistic strategy that may operate through chemical deception.
Image credit: Roshan Vijendravarma
01/07/2019
Research Article
A highly conserved mechanism links the microtubule minus end–directed motor dynein to structurally diverse cargo adaptors through its light intermediate chain; this interaction is crucial for dynein function in vivo.
Image credit: pbio.3000100
On the eve of the UN General Assembly meeting on TB, Christoph Grundner urged the need to consider basic research as an essential component of any future anti-TB strategy.
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
Rodrigo Almeida argues that considering the social context of emerging plant diseases and effective science communication are essential for the management epidemics.
Oswald Schmitz suggests that studying how species produce ecological functions can be like watching jazz musicians improvise as they respond and adapt to one another to create their music.
Meta-research may not be as click-worthy as a meta-pug – a pug dog dressed up in a pug costume – but it is crucial to understanding research, says Lisa Bero in this Research Matters article.
Meet Managing Editor Hashi Wijayatilake in San Diego, CA.
December 8-12, 2018
Meet Senior Editor Ines Alvarez-Garcia in Roscoff, France.
November 19-23, 2018
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