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Copper Helps Fat Cells Select Fuel

September 10, 2018

Copper Helps Fat Cells Select Fuel

A study of adipocytes by Haojun Yang, Svetlana Lutsenko and colleagues shows that copper is essential for balancing their sugar and lipid utilization; this is mediated by the activation of the copper-dependent amino-oxidase AOC3/SSAO.

Image credit: Hannah Pierson

Celebrate our 15th Anniversary! Tweet @PLOSBiology #PLOSBIO15

PLOS Biology's XV Collection

09/12/2018

research article

How Toxo Turns off Host Calcium Signaling

Alessandro Uboldi, Christopher Tonkin and co-workers find that the cAMP-dependent protein kinase A enables human parasite Toxoplasma gondii to establish a replicative niche in newly invaded host cells by switching off calcium signaling.

Image credit: pbio.2005642

How Toxo Turns off Host Calcium Signaling

Recently Published Articles

Current Issue

Current Issue August 2018

09/12/2018

research article

Song-Learning: Practice Makes Perfect

Shin Hayase, Kazuhiro Wada and colleagues show that a vocal learner, the zebra finch, actively controls its vocal learning plasticity through self-motivated vocal practice; during the critical period of song learning, vocal practice influences the expression dynamics of activity-dependent, but not age-related genes.

Image credit: Flickr user Paul Balfe & pbio.2006537

Song-Learning: Practice Makes Perfect

09/12/2018

methods and resources

Epitranscriptomics for Small Samples

Yong Zeng, Shiyan Wang, Housheng Hansen He and co-workers describe a refined version of the MeRIP-seq protocol, allowing the detection of the N6-methyladenosine RNA modification (epitranscriptome profiling) in samples where limited material is available, such as patient tumors. 

Image credit: pbio.2006092

Epitranscriptomics for Small Samples

09/13/2018

methods and resources

A Parts-List for the Malaria Apicoplast

Michael Boucher, Ellen Yeh and colleagues use a combination of proximity biotinylation-based proteomics and machine learning to improve the accuracy of the apicoplast proteome in the malaria parasite Plasmodium falciparum, identifying proteins of potential biological and therapeutic interest.

A Parts-List for the Malaria Apicoplast

Image credit: pbio.2005895

09/12/2018

research article

Tiny Ribosomal Helper Aids Recovery from Starvation

Yinuo Wang, Wendy Gilbert and colleagues show that the previously uncharacterized yeast protein Lso2 and its human ortholog CCDC124 bind to a universally conserved region of the ribosome; Lso2 is required in yeast for global translation during recovery from extended starvation.

Tiny Ribosomal Helper Aids Recovery from Starvation

Image credit: pbio.2005903

09/10/2018

research article

Transcriptional Dynamics of NF-κB

The NF-κB family of transcription factors regulate cellular responses to a wide variety of environmental cues. Mingming Zhao, Ranjan Sen and co-workers reveal a time-dependent cascade of NF-κB-dependent gene expression in activated B lymphoma cells and identify mechanisms by which these unique kinetic patterns are established.

Transcriptional Dynamics of NF-κB

Image credit: pbio.2006347

09/12/2018

formal comment

Microbiome and 'Self'

This Formal Comment questions a claim made in a recent Essay that the microbiome affects our concept of ‘self,’ and challenges the resulting call for ‘microbial humanities. Also read the response.

Microbiome and 'Self'

Image credit: pbio.2005358

09/04/2018

Short Reports

Importance of the Lymph Node Microenvironment

Human T cells show restricted activation in the presence of fibroblastic reticular cells from lymphoid organs. This suppression can be reversed in live tissue slices by using inhibitors.

Importance of the Lymph Node Microenvironment

Image credit: Sara Cruz Migoni

09/04/2018

Perspective

No More Paywalls for European Science

National funders, the EC and the ERC announce plans to make Open Access publishing mandatory for recipients of their agencies’ research funding.

No More Paywalls for European Science

Image credit: Pixabay and Wikimedia Commons

09/17/2018

plos biologue

Living l’AVIDA Loca

In the 8th of our 12 blog posts to mark our 15th anniversary, Harmit Malik explores the use of the AVIDA "digital organism" platform to probe the Faustian evolutionary deal struck between somatic and germ cells.

Living l’AVIDA Loca

Image credit: pbio.1001859

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