06/23/2022
Short Reports
Snake fungal disease is emerging in eastern North America, but its origins have been unclear. Jason Ladner, Jeffrey Lorch and colleagues use population genetic data to show that the fungus that causes the disease was introduced multiple times to North America over the last few hundred years.
Image credit: pbio.3001676
Current IssueMay 2022
06/22/2022
Methods and Resources
Juliana Taube, Paige Miller and John Drake compile and standardize reported infectious disease transmission trees to analyze trends in superspreader frequency and generation; these data support theories that intermediate dispersion parameters favor superspreading events, and that superspreaders generate other superspreaders.
Image credit: pbio.3001685
06/21/2022
Research Article
Response to acute oxygen shortages is indispensable to aerobic life, but its molecular mechanisms are poorly understood. Lina Zhao, Lorenz Fenk, Lars Nilsson, Mario de Bono, Changchun Chen and colleagues reveal that high levels of cGMP and reactive oxygen species (ROS) prevent the nematode Caenorhabditis elegans from escaping hypoxia.
Image credit: pbio.3001684
06/16/2022
Perspective
Tropical biology is currently largely absent from undergraduate curricula. Ann Russell and co-authors argue that the integration of authentic research in tropical biology could promote internationality among scientists and provide experiential learning that enables students to address complex global problems.
Image credit: J. Leighton Reid
06/16/2022
Research Article
Olivier Mercey, Paul Guichard, Virginie Hamel and colleagues use ultrastructure expansion microscopy on mouse retina to reveal the presence of a novel structure inside the photoreceptor connecting cilium that protects the outer segment against degeneration. See also the related Primer.
Image credit: Olivier Mercey
06/14/2022
Research Article
Gamma oscillations in visual cortex have been proposed to play an important role in feature binding, but this role has recently been questioned. Vinay Shirhatti, Poojya Ravishankar and Supratim Ray show that visual stimulus-induced gamma oscillations are highly attenuated with even small discontinuities in the stimulus. See also the related Primer.
Image credit: pbio.3001666
06/14/2022
Research Article
Valproic acid induces cellular senescence in neuroepithelial cells and blocks their differentiation, suggesting that aberrant senescence in the embryo may contribute to postnatal cognitive defects.
Image credit: pbio.3001664
06/13/2022
Short Reports
Context-dependent engagement of distinct intracellular signaling pathways within a single sensory neuron type is sufficient to switch response to an odorant from attraction to aversion.
Image credit: pbio.3001677
06/10/2022
Research Article
The polyol pathway is involved in glucose-responsive activation of Mondo/ChREBP-mediated metabolic remodeling in both mice and flies.
Image credit: Hiroko Sano
06/10/2022
Essay
Assuming technology advanced enough to fully manipulate our brains, this thought experiment addresses the question of whether action potentials cause consciousness.
Image credit: pbio.3001651
Raquel Lieberman discusses her work on the protein myocilin, implicated in glaucoma, but whose normal function remains unclear after over 20 years.
Susanna Bidgood explores the future of using poxviruses as versatile tools for cell biology research.
Rachel Harding proposes that open notebooks present an opportunity for researchers to showcase their work and rapidly advance science in their field
On the eve of the UN General Assembly meeting on TB, Christoph Grundner urged the need to consider basic research as an essential component of any future anti-TB strategy.
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
June 29 - July 2
Meet Editor in Chief Nonia Pariente (virtual)
July 5-7
Meet Editor in Chief Nonia Pariente
July 17-21
Meet Associate Editor Richard Hodge
August 7-12
Meet Senior Editor Kris Dickson
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