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Scar/WAVE Phosphorylation and Pseudopod Lifetime

August 3, 2020

Scar/WAVE Phosphorylation and Pseudopod Lifetime

Scar/WAVE is the dominant driver of actin protrusions in migrating cells. Shashi Prakash Singh, Robert Insall and co-workers show that phosphorylation of Scar/WAVE, previously thought essential, is dispensable, but modulates pseudopods to make them smaller and shorter-lived.

Image credit: pbio.3000774

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08/06/2020

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Illustrating the Pandemic

David Goodsell, Maria Voigt, Christine Zardecki and Stephen Burley describes how visually striking illustrations of SARS coronaviruses can capture the state of knowledge of the field and provide a touchstone for outreach and education about these pathogens.

Image credit: David Goodsell

Illustrating the Pandemic

Recently Published Articles

Current Issue

Current Issue July 2020

08/06/2020

Short Reports

Inflammasome Mediates Radiation Damage

Radiotherapy is a commonly used conditioning regimen for bone marrow transplantation; cytotoxicity limits the use of this life-saving therapy, but the underlying mechanisms remain poorly defined. Jianqiu Xiao, Chun Wang, Gabriel Mbalaviele and co-workers reveal a continuum of the effects of radiation, relayed by the inflammasome–gasdermin D axis, initially affecting host cells and, ultimately, harming transplanted cells.

Image credit: pbio.3000807

Inflammasome Mediates Radiation Damage

08/06/2020

Research Article

Symmetry-Breaking in Centrosomes

Centrosomes contain an older ‘mother’ and a younger ‘daughter’ centriole, but the mechanisms regulating centrosome asymmetry and biased centrosome segregation are unclear. Emmanuel Gallaud, Anjana Ramdas Nair, Clemens Cabernard and co-authors show that in fly neural stem cells the centrosomes become molecularly asymmetric during mitosis, aiding in spindle orientation and biased centrosome segregation.

Image credit: pbio.3000762

Symmetry-Breaking in Centrosomes

08/03/2020

Research Article

Same Genes, Different Clocks...

How do genetically identical cells exhibit a different circadian phenotype? KL Nikhil, Sandra Korge and Achim Kramer reveal that a single parent clone can produce progeny with a wide distribution of circadian periods and that this heterogeneity, in addition to being stochastically driven, has a heritable component, likely via heritable epigenetic variation in gene expression regulation.

Same Genes, Different Clocks...

Image credit: pbio.3000792

08/03/2020

Research Article

Winnowing Rearrangements for Mating type

In the ciliate Tetrahymena thermophila, mating type determination requires complex DNA rearrangements to produce a type-specific MAT gene pair for each of seven possible mating types. I-Ting Lin and Meng-Chao Yao show that DNA recombination produces a large number of unusual MAT gene pairs, but a KU-dependent process ensures only one normal pair is retained in a mature cell.

Winnowing Rearrangements for Mating type

Image credit: pbio.3000756

08/03/2020

Research Article

Why Hungry Animals are More Alert

Hungry animals are often better off looking for food than sleeping. Deniz Ertekin, Bruno van Swinderen and co-workers show that attention is indeed sharpened while sleep is decreased in flies that have been genetically starved. A starvation cue from the peripheral fat stores to insulin-expressing cells in the brain seems responsible for sharpening attention in the face of decreased sleep.

Why Hungry Animals are More Alert

Image credit: pbio.3000548

07/31/2020

short report

Zinc: an Ancient Shield against Multiple Fertilization

This study shows that eggs from diverse species release zinc upon fertilization, suggesting that this strategy to protect eggs from multiple fertilizations may have evolved more than 650 million years ago.

Zinc: an Ancient Shield against Multiple Fertilization

Image credit: pbio.3000811

07/31/2020

Research Article

Wiring Complex Primate Behavior

A comparison of the organization of connections in the temporal association cortex sheds light on specializations underlying the unique behavioral abilities of monkeys, chimpanzees, gorillas and humans.

Wiring Complex Primate Behavior

Image credit: pbio.3000810

07/30/2020

methods and resources

DNA Demethylation Patterns in Early Human Life

CLEVER-seq delineates the 5-formylcytosine landscape of human early embryos at single-cell resolution, enhancing our understanding of active demethylation processes during human embryogenesis.

DNA Demethylation Patterns in Early Human Life

Image credit: pbio.3000799

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