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(Dis)Organizing Mosquito Eggshells

January 8, 2019

(Dis)Organizing Mosquito Eggshells

Jun Isoe, Roger Miesfeld and colleagues use an RNAi functional screen of 40 Aedes aegypti genes specific to the mosquito lineage to identify EOF1, a protein that plays an essential role in mosquito eggshell formation and melanization.

Image credit: pbio.3000068

Celebrate our 15th Anniversary! Tweet @PLOSBiology #PLOSBIO15

PLOS Biology's XV Collection

01/10/2019

Community Page

Bio-On-Magnetic-Beads (BOMB): Cheaper, Quicker, Safer RNA/DNA

Phil Oberacker, Peter Stepper, Donna Bond, Timothy Hore, Tomasz Jurkowski and co-workers present open-source nucleic acid purification and handling protocols based on functionalised magnetic beads, with the aim of transforming life science research practice and its economics.

Image credit: pbio.3000107

Bio-On-Magnetic-Beads (BOMB): Cheaper, Quicker, Safer RNA/DNA

Recently Published Articles

Current Issue

Current Issue December 2018

01/10/2019

research article

Sex Pheromones Deceive Cannibals

Sunitha Narasimha, Roshan Vijendravarma and colleagues show that maternal sex pheromones incorporated within the wax layer of the fruit fly eggshell prevent the egg from leaking, and conceal it from predation by same-species larvae in an anti-cannibalistic strategy that may operate through chemical deception.

Image credit: Roshan Vijendravarma

Sex Pheromones Deceive Cannibals

01/07/2019

Research Article

Coupling Dynein to Diverse Cargoes

Ricardo Celestino, Morkos Henen, José Gama, Reto Gassmann, Beat Vögeli and colleagues find that a highly conserved mechanism links the microtubule minus end–directed motor dynein to structurally diverse cargo adaptors through its light intermediate chain; this interaction is crucial for dynein function in vivo.

Image credit: pbio.3000100

Coupling Dynein to Diverse Cargoes

01/04/2019

research article

How RNA Viruses Hijack Autophagy

The cellular autophagy pathway sculpts intracellular membranes to degrade or transport cytoplasmic contents. Emma Abernathy, Karla Kirkegaard and co-authors identify components of this pathway that are hijacked by polio, dengue and Zika viruses for their own membrane-associated amplification and dissemination.

How RNA Viruses Hijack Autophagy

Image credit: pbio.2006926

01/04/2019

research article

Skull-Shaped Hydrogenosome TOMs

Abhijith Makki, Jan Tachezy and co-authors show that the highly divergent outer membrane translocase (TOM) from the Trichomonas hydrogenosome (an organelle related to mitochondria) is composed of conserved core and lineage-specific subunits, and has an unconventional skull-like triplet-pore structure.

Skull-Shaped Hydrogenosome TOMs

Image credit: pbio.3000098

01/09/2019

Community Page

Annotated Scientific Literature for Teaching

Matthew Kararo and Melissa McCartney present Science in the Classroom (SitC), a tool for undergraduate educators to introduce their students to primary scientific literature. Annotations scaffold the readers so that authentic scientific practices are explained and recognized for their importance in scientific communications.

Annotated Scientific Literature for Teaching

Image credit: pbio.3000103

01/02/2019

Meta-Research Article

The Inefficiencies of Scientific Funding Competitions

Economic modelling shows that grant-proposal competitions are inevitably inefficient when the number of awards is small, but efficiency can be restored by a number of process modifications.

The Inefficiencies of Scientific Funding Competitions

Image credit: Flickr user Reynermedia

12/31/2018

research article

Making Melanin

Cryo-trapped crystal structures of tyrosinase in a complex with its “caddie” protein reveal structural insights into the catalytic mechanism of tyrosinase, the rate-limiting enzyme in the production of melanin.

Making Melanin

Image credit: pbio.3000077

01/11/2019

plos biologue

Ethical Oversight of Animal Research

In this final blog post to celebrate our 15th anniversary, Jonathan Kimmelman explores two PLOS Biology studies that identify poor practices in ethical oversight of both human and animal experiments.

Ethical Oversight of Animal Research

Image credit: Maggie Bartlett, NHGRI

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