Advertisement
Speech echoes in the brain

February 26, 2021

Speech echoes in the brain

Just as a child on a swing continues to move after the pushing stops, Sander van Bree, Ediz Sohoglu, Matthew Davis and Benedikt Zoefel reveal similar entrained rhythmic echoes in brain activity after hearing speech and electrical brain stimulation; perturbation with tACS shows that these brain oscillations help listeners to understand speech.

Image credit: pbio.3001142

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

02/25/2021

Research Article

A phosphatase in the Hippo pathway

Ruyuan Zhou, Qirou Wu, Mengqiu Wang, Pinglong Xu and colleagues identify PPM1A as a phosphatase which dephosphorylates Yap, a key effector of Hippo signaling. This dephosphorylation event governs the regeneration of intestine and liver upon injury, and therefore represents a candidate therapeutic target for the treatment of Hippo signaling-related diseases such as colitis

Image credit: pbio.3001122

A phosphatase in the Hippo pathway

Recently Published Articles

Current Issue

Current Issue January 2021

02/25/2021

Methods and Resources

A SARS-CoV-2 toolkit for COVID-19 research

To help meet the ensuing demand for COVID-19 reagents, Suzannah Rihn, Andres Merits, Siddharth Bakshi, Matthew Turnbull, Arvind Patel, Ali Zaid, Sam Wilson, Suresh Mahalingam and co-authors present an openly available ‘coronavirus toolkit’ and describe the generation and validation of these tools, including a simple SARS-CoV-2 reverse genetics system and a near-comprehensive panel of SARS-CoV-2 antibodies.

Image credit: pbio.3001091

A SARS-CoV-2 toolkit for COVID-19 research

02/24/2021

Research Article

TGF-β signaling promotes metastasis by two routes

TGF-β signaling is critical for promoting cancer metastasis, primarily via Smad-dependent regulation of the epithelial-mesenchymal transition; Mengmeng Niu, Yajun He, Zhi-Xiong Jim Xiao and colleagues reveal that non-canonical TGF-β signaling stabilizes the E3 ubiquitin ligase FBXO3 to target ΔNp63α for degradation, resulting in downregulation of adhesion molecules and promotion of breast cancer metastasis.

Image credit: pbio.3001113

TGF-β signaling promotes metastasis by two routes

02/24/2021

Community Page

Meta-research: “learn by doing”

Tracey Weissgerber describes a participant-guided "learn by doing" initiative, in which a multidisciplinary, global team of early career researchers learned meta-research skills by working together to design, conduct and publish a meta-research (science of science) study. Participants can now apply these skills to solve problems in their own fields.

Meta-research: “learn by doing”

Image credit: Wikimedia Commons Nessma Elaassar

02/23/2021

Research Article

Suppression of microexons promotes tumor growth

Using data from The Cancer Genome Atlas, Sarah Head, Martin Schaefer, Luis Serrano and co-workers show that the splicing factor SRRM4 and its program of differentiation-promoting microexons are downregulated across tumor types with remarkable consistency, providing tumors with a proliferative advantage.

Suppression of microexons promotes tumor growth

Image credit: pbio.3001138

02/19/2021

Research Article

Rules for assembling a microbiome

Humans and many other hosts establish a diverse community of beneficial microbes anew each generation, but what determines the success of the assembly process remains poorly understood. Katharine Coyte, Kevin Foster and colleagues develop ecological theory that reveals the rules underlying the assembly of such host-associated microbiota.

Rules for assembling a microbiome

Image credit: pbio.3001116

02/18/2021

Research Article

Navigating the rhizosphere

An important agricultural pest, the western corn rootworm, integrates nutrients (sugars) and plant defense compounds (benzoxazinoids) to navigate the maize rhizosphere and feed on the most nutritious roots.

Navigating the rhizosphere

Image credit: pbio.3001114

02/17/2021

Research Article

Hyperactive platelets in COVID-19

Why is SARS-CoV-2 infection associated with an increased thrombotic risk? Disease severity is associated with higher platelet volume and lower platelet:neutrophil ratio; all COVID-19 patients possess hyperactive circulating platelets.

Hyperactive platelets in COVID-19

Image credit: David Goodsell

02/17/2021

Research Article

Nonsense-mediated decay controls herpesvirus latency

The nonsense-mediated decay pathway suppresses reactivation of the human oncogenic herpesviruses EBV and KSHV by regulating the abundance of viral polycistronic transactivator transcripts.

Nonsense-mediated decay controls herpesvirus latency

Image credit: pbio.3001097

02/16/2021

Short Reports

Corin makes sweat salty

Sweating is a basic skin function in body temperature control, and salt excretion and reabsorption in sweat glands are essential for salt-water balance. Corin, a protease that activates atrial natriuretic peptide, is a key enzyme in regulating salt excretion in the skin.

Corin makes sweat salty

Image credit: pbio.3001090

Get new content from PLOS Biology in your inbox

Thank you! You have successfully subscribed to the PLOS Biology newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

Try again