02/25/2021
Research Article
A phosphatase in the Hippo pathway
Ruyuan Zhou, Qirou Wu, Mengqiu Wang, Pinglong Xu and colleagues identify PPM1A as a phosphatase which dephosphorylates Yap, a key effector of Hippo signaling. This dephosphorylation event governs the regeneration of intestine and liver upon injury, and therefore represents a candidate therapeutic target for the treatment of Hippo signaling-related diseases such as colitis
Image credit: pbio.3001122
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