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Amplifying Centrioles in your Nose

September 15, 2020

Amplifying Centrioles in your Nose

Olfactory sensory neurons (OSNs) have about fifteen cilia at the end of a dendrite that projects into the nasal cavity. Kaitlin Ching and Tim Stearns show that the progenitors of these neurons amplify their centrioles and then proceed to divide one or more times to become OSNs.

Image credit: pbio.3000852

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

09/17/2020

Methods and Resources

CombiANT: Antibiotic Interaction Testing Made Easy

Existing methods for identifying efficient combinations of antibiotics are time-consuming and costly, restricting their use in clinics and research. Nikos Fatsis-Kavalopoulos, Dan Andersson and co-authors describe the novel CombiANT methodology, which uses defined diffusion landscapes of three antibiotics to permit rapid and low-cost synergy quantification between all antibiotic pairs.

Image credit: pbio.3000856

CombiANT: Antibiotic Interaction Testing Made Easy

Recently Published Articles

Current Issue

Current Issue August 2020

09/16/2020

Research Article

Two-Factor Authentication... for Mulberry Leaves

Silkworm larvae are well known for their preference for mulberry leaves; Haruka Endo, Kana Tsuneto, Ryoichi Sato and colleagues show that they choose their food by using a two-factor host acceptance system, deploying two different organs and sets of chemosensory neurons with differing sensitivities operating sequentially in time.

Image credit: Kana Tsuneto

Two-Factor Authentication... for Mulberry Leaves

09/14/2020

Community Page

The World Coral Conservatory: A Noah's Ark for Corals

Global change is causing a widespread decline in coral reefs. Didier Zoccola, Denis Allemand and co-authors propose the building of the World Coral Conservatory, a “Noah's Ark” biological repository that taps into the network of the world’s public aquaria and coral reef scientists, in order to preserve the fast-disappearing biodiversity of coral reefs.

Image credit: pbio.3000823

The World Coral Conservatory: A Noah's Ark for Corals

09/14/2020

Research Article

Two Routes to Plant Immunity

Svenja Saile, Pierre Jacob, Farid El Kasmi and co-workers shows that two intracellular plant Nod-like immune receptor (NLR-) subfamilies act with unequal redundancy in their roles in plant disease resistance to virulent and avirulent pathogens, in effector-triggered immunity induced gene expression and in immunity-associated cell death.

Two Routes to Plant Immunity

Image credit: pbio.3000783

09/12/2020

Primer

Open-Source Experimental Control Systems

Closed loop experimental configurations can drive chemical systems to become more lifelike by pushing them out of equilibrium; similar experimental arrangements can be applied to biological research. Christopher Forman uses the recently published Chi-Bio system to explore the emerging trend in building open source libraries of hardware which has enabled some excellent science as well as bringing the price tag down.

Open-Source Experimental Control Systems

Image credit: pbio.3000858

09/08/2020

Short Reports

Imprecision in Working Memory

Working memory is imprecise, and these imprecisions can be explained by the combined influences of random diffusive error and systematic drift towards a set of stable states (‘attractors’); however, the neural correlates of diffusion and drift remain unknown. This neuroimaging study by Qing Yu, Timothy Buschman and co-workers reveals neural substrates that underlie noise and biases in behavioral performance of human visual memory.

Imprecision in Working Memory

Image credit: pbio.3000854

09/08/2020

Research Article

Regulating the Length of Muscle Thin Filaments

Leiomodin is critical in thin filament assembly and maintenance, but its role is unclear. A 3D model of a complex between leiomodin and the actin pointed end reveals a mechanism for regulating the length of thin filaments in striated muscle.

Regulating the Length of Muscle Thin Filaments

Image credit: pbio.3000848

09/08/2020

Research Article

Brain Stimulation Improves Reading Accuracy in Dyslexia

Enhancing low-gamma neural oscillations by applying 30-Hz transcranial electrical stimulation to the left auditory cortex improves phonemic processing and reading accuracy in dyslexia.

Brain Stimulation Improves Reading Accuracy in Dyslexia

Image credit: pbio.3000833

09/04/2020

Research Article

Bacterium's Role in Esophageal Cancer

Invasion of the bacterium Porphyromonas gingivalis enhances the aggressive progression of esophageal squamous cell carcinoma via the TGFβ/Smad and TGFβ/YAP/TAZ pathways.

Bacterium's Role in Esophageal Cancer

Image credit: pbio.3000825

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