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MHC Class II Chaperone HLA-DO and Autoimmune Disease

February 18, 2020

MHC Class II Chaperone HLA-DO and Autoimmune Disease

A combination of cellular, molecular and in vivo approaches by Robin Welsh, Nianbin Song, Scheherazade Sadegh-Nasseri and colleagues reveals that the non-classical MHC class II chaperone DO controls CD4 T cell thymic selection; its absence leads to susceptibility to two murine autoimmune diseases, collagen-induced arthritis and experimental autoimmune encephalomyelitis.


Image credit: pbio.3000590

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology

PLOS Biologue

02/20/2020

Research Article

How to Go to Sleep

A study in nematodes by Elisabeth Maluck, Inka Busack, Henrik Bringmann and co-authors shows that to understand sleep state switching, the flip-flop model for sleep regulation needs to be complemented by additional wake-active sleep-promoting neurons that activate sleep-active sleep-promoting neurons to induce sleep.

Image credit: pbio.3000361

How to Go to Sleep

Recently Published Articles

Current Issue

Current Issue January 2020

02/18/2020

Research Article

The Daily Brain

The brain exhibits substantial diurnal variation in physiology and function. A large-scale fMRI study by Csaba Orban, Thomas Yeo and co-workers reveals that the brain’s global signal amplitude, typically elevated during drowsy states, unexpectedly reduces steadily as the day progresses.

Image credit: pbio.3000602

The Daily Brain

02/13/2020

Research Article

NRF2, Primary Cilia and Hedgehog

Pengfei Liu, Donna Zhang and co-authors reveal a novel role for the transcription factor NRF2 in controlling the primary cilium and its associated Hedgehog signaling pathway; they also uncover a mechanism by which NRF2 hyperactivation promotes tumor progression.

Image credit: Pengfei Liu

NRF2, Primary Cilia and Hedgehog

02/14/2020

perspective

Seaweed Germplasm Banking

Macroalgal germplasm banking is an important resource for biodiversity conservation, human food security, and industry innovation. This Perspective article by Rachael Wade, Filipe Alberto and co-authors maintains that an international, coordinative initiative is needed to fully develop and capitalize on this resource.

Seaweed Germplasm Banking

Image credit: Flickr user Rich Brooks

02/11/2020

Research Article

Tracking Mumps Outbreaks

Shirlee Wohl, Hayden Metsky, Stephen Schaffner, Paul Rota, Lawrence Madoff, Nathan Yozwiak, Bronwyn MacInnis, Sandra Smole, Yonatan Grad, Pardis Sabeti and co-workers study recent mumps outbreaks in the United States to reveal transmission patterns within and between Massachusetts communities, highlighting the importance of combining detailed genomic and epidemiological data, both locally and nationwide.


Tracking Mumps Outbreaks

Image credit: pbio.3000611

02/10/2020

research article

Light-Sensitive Adipocytes

Brown adipose tissue plays a pivotal role in energy homeostasis and serves as a metabolic sink for glucose and fatty acid. Mari Sato, Tadataka Tsuji, Yu-Hua Tseng and co-workers demonstrate a novel light-sensing mechanism in mice via the photoreceptor Opsin3 that regulates fuel utilization and mitochondrial activity of brown adipocytes.

Light-Sensitive Adipocytes

Image credit: pbio.3000630

02/10/2020

Research Article

How Ebola Virus Enters the Cell

The Ebola virus envelope glycoprotein is a membrane fusion machine required for the virus to enter into host cells. This study reveals the conformational changes that the envelope glycoprotein undergoes during the membrane fusion process.

How Ebola Virus Enters the Cell

Image credit: Flickr user NIAID

02/11/2020

Community Page

Improving Biomedical Research 

Daniel Strech, Tracey Weissgerber and Ulrich Dirnagl describe an ongoing large-scale structured initiative at the Berlin Institute of Health which aims at improving the robustness, reproducibility and transparency of research in an academic biomedical setting.

Improving Biomedical Research 

Image credit: pbio.3000576

02/06/2020

Research Article

Selection on Mimicry in Butterflies

Selection scans across multiple populations and species of Heliconius butterfly reveal pervasive selection on novel and introgressed color pattern variation, suggesting high rates of color pattern turn-over events.

Selection on Mimicry in Butterflies

Image credit: Chris Jiggins

02/06/2020

Short Reports

Rare Cells Suppress Sensory Responses

Despite their sparsity (about 0.5% of neurons), a population of interneurons in the mouse barrel cortex that express genes associated with both cholinergic and GABAergic signalling can effectively modulate sensory processing in the cortical microcircuit.

Rare Cells Suppress Sensory Responses

Image credit: Amir Dudai & Nadav Yayon

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