11/08/2018
methods and resources
Sophie Bagur, Karim Benchenane and co-authors show that gamma oscillations in the olfactory bulb track changes in vigilance states with remarkable precision, allowing the development of a novel fully brain-based sleep-scoring methodology and real-time monitoring of depth of anaesthesia.
Image credit: pbio.2005458
Current Issue October 2018
11/08/2018
RESEARCH ARTICLE
Bioinformatic analysis and experiments on clinical samples and mouse models of breast cancer, by Peng Tan, Leng Han, Weidong Han, Yubin Zhou and colleagues, unveil a new signaling protein degradation pathway involving TRIM59 and PDCD10 that modulates breast cancer cell growth, survival, and metastasis.
Image credit: pbio.3000051
11/02/2018
SHORT REPORT
Jianqiu Xiao, Chun Wang, Gabriel Mbalaviele and co-authors show that pyroptosis mediated by the pore-forming protein gasdermin D plays a crucial role in the pathogenesis of neonatal-onset multisystem inflammatory disease (NOMID), a severe genetic autoinflammatory disorder resulting from activating mutations in the NLRP3/cryopyrin gene.
Image credit: pbio.3000047
11/07/2018
PRIMER
Martin Stegmann discusses the recent demonstration that EBP1 is a major transcriptional and translational regulator across kingdoms, acting downstream of EGFR signalling in animals and the central receptor kinase FERONIA in plants. Read the related Research Article.
Image credit: pbio.2006340
11/01/2018
Research Article
Samantha Fox, Paul Southam, Florent Pantin, Enrico Coen and colleagues use a combination of computational modelling and live imaging to show how leaves form through dual spatiotemporal control of growth and cell division, with cross-connections between them.
Image credit: pbio.2005952
10/31/2018
SHORT REPORT
Cells lacking essential patterning determinants are eliminated from developing tissues by apoptosis; Samuel Crossman, Sebastian Streichan and Jean-Paul Vincent show that cell death in fruit fly segmentation mutants results from disruption of the pattern of EGFR signalling, which in normal embryos coordinates segment size with patterning information.
Image credit: pbio.3000027
10/31/2018
Research Article
Foxp3+ regulatory T cells require an intact IL-4Rα-mediated signaling pathway to efficiently contain immune responses and control tissue inflammation during helminth infection.
Image credit: pbio.2005850
10/30/2018
Research Article
The first example of natural variation in tolerance of transposable elements, whereby host cells modulate the deleterious effects without regulating transposition. Read the accompanying Primer.
Image credit: pbio.2006040
10/26/2018
research article
Sound-evoked extracellular field potential recordings and mathematical modeling reveal a neural code for the extraordinarily precise (microsecond) registration of the timing of acoustic events in echolocating bats.
Image credit: pbio.2006422
11/08/2018
Channel
The PLOS Responding to Climate Change Channel highlights research efforts from a range of disciplines focussed on understanding, evaluating, predicting, mitigating, and adapting to the causes and effects of the changing climate.
Image credit: Victor Benard, Unsplash
On the eve of the UN General Assembly meeting on TB, Christoph Grundner urged the need to consider basic research as an essential component of any future anti-TB strategy.
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
Rodrigo Almeida argues that considering the social context of emerging plant diseases and effective science communication are essential for the management epidemics.
Oswald Schmitz suggests that studying how species produce ecological functions can be like watching jazz musicians improvise as they respond and adapt to one another to create their music.
Meta-research may not be as click-worthy as a meta-pug – a pug dog dressed up in a pug costume – but it is crucial to understanding research, says Lisa Bero in this Research Matters article.
This Open Highlight investigates how the traits that distinguish species have developed and diversified over time.
How resistance arises at the cellular level, how it evolves and spreads, and how we can combat it.
How animals combine information from the outside world and from within their own bodies to decide what they should eat.
How the engulfment of a small bacterium by a larger archaeon more than a billion years ago resulted not in death, but in one of the most successful partnerships on earth.
The composition and function of microbiomes are critical for most animals and plants; how do relationships between hosts and microbes evolve over time?
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