11/15/2018
RESEARCH ARTICLE
Tracy Chih-Ting Koubkova-Yu, Jung-Chi Chao, and Jun-Yi Leu show that yeast cells carrying the heat shock protein Hsp90 from a distant species,Yarrowia, have an increased potential to evolve divergent phenotypes after propagating under normal growth conditions for thousands of generations.
Image credit: pbio.2006450
Current Issue October 2018
11/14/2018
RESEARCH ARTICLE
Jun Guo, Youhua Zhang, Hua Li, Huiying Chu, Guohui Li, Jianfeng Chen, Chenqi Xu and colleagues find that calcium regulates the structure and function of integrin by disrupting an interaction between a “snorkeling” basic amino acid and an acidic phospholipid within the membrane.
Image credit: pbio.2006525
11/16/2018
research article
A protein engineering approach by Sisi Zheng, Guolin Ma, Lian He, Yubin Zhou, Youjun Wang and colleagues delineates how two STIM homologs, STIM1 and STIM2, differentially sense and respond to calcium signals, overcome intramolecular autoinhibition, and trigger calcium influxes into mammalian cells.
Image credit: pbio.2006898
11/13/2018
FORMAL COMMENT
This Formal Comment by Aníbal Pauchard and co-authors responds to a previous Perspective article by Martin Schlaepfer, acknowledging that more comprehensive assessments of global biodiversity including native and non-native species are needed, but maintaining that we must resist the temptation to oversimplify the concept of biodiversity. See also Schlaepfer's reply.
Image credit: bewildlife, Pixabay
11/12/2018
RESEARCH ARTICLE
David Rogers, Ellen McConnell, Jasmine Ono and Duncan Greig show that low levels of genome sequence divergence can keep yeast populations reproductively isolated by interfering with the segregation of chromosomes during gamete production in hybrids, thereby resulting in hybrid sterility.
Image credit: pbio.2005066
11/09/2018
SHORT REPORTS
Cryo-electron tomography of periplasmic flagella in the Lyme disease bacterium Borrelia burgdorferi, by Zhuan Qin, Jiagang Tu, Md Motaleb, Jun Liu and colleagues reveals a distinct cytoplasmic ATPase complex and an atypical interaction with the flagellar C-ring.
Image credit: pbio.3000050
11/08/2018
methods and resources
Gamma oscillations in the olfactory bulb track changes in vigilance states with remarkable precision, allowing the development of a novel fully brain-based sleep-scoring methodology.
Image credit: pbio.2005458
11/08/2018
RESEARCH ARTICLE
Bioinformatic analysis and experiments unveil a new signaling protein degradation pathway involving TRIM59 and PDCD10 that modulates breast cancer cell growth, survival, and metastasis.
Image credit: pbio.3000051
11/02/2018
SHORT REPORT
Pyroptosis mediated by the pore-forming protein gasdermin D plays a crucial role in the pathogenesis of neonatal-onset multisystem inflammatory disease (NOMID).
Image credit: pbio.3000047
11/16/2018
Biologue
As part of our 15th anniversary celebrations, Sally Lowell highlights a paper by James Glover and colleagues that set out to study the putative Turing mechanism that patterns hair follicles but found something unexpected.
Image credit: Flickr user lensnmatter
On the eve of the UN General Assembly meeting on TB, Christoph Grundner urged the need to consider basic research as an essential component of any future anti-TB strategy.
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
Rodrigo Almeida argues that considering the social context of emerging plant diseases and effective science communication are essential for the management epidemics.
Oswald Schmitz suggests that studying how species produce ecological functions can be like watching jazz musicians improvise as they respond and adapt to one another to create their music.
Meta-research may not be as click-worthy as a meta-pug – a pug dog dressed up in a pug costume – but it is crucial to understanding research, says Lisa Bero in this Research Matters article.
This Open Highlight investigates how the traits that distinguish species have developed and diversified over time.
How resistance arises at the cellular level, how it evolves and spreads, and how we can combat it.
How animals combine information from the outside world and from within their own bodies to decide what they should eat.
How the engulfment of a small bacterium by a larger archaeon more than a billion years ago resulted not in death, but in one of the most successful partnerships on earth.
The composition and function of microbiomes are critical for most animals and plants; how do relationships between hosts and microbes evolve over time?
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