06/12/2025
Research Article
Conflicting results have been observed regarding changes in synaptic strength in the cerebral cortex during the sleep-wake cycle. This computational study by Fukuaki Kinoshita, Hiroki Ueda and co-workers provides a comprehensive understanding and unified framework about synaptic dynamics during the sleep-wake cycle.
Image credit: pbio.3003198
Current Issue May 2025
06/12/2025
Research Article
Epigenetic regulators such as EZH2 are known to be mutated in B cell lymphomas, but the effect of these mutations remains unclear. Ofir Griess, Guy Ron, Efrat Shema and co-authors uncover a role for mutant EZH2 in lymphomagenesis, also establishing a new method for measuring epigenetic heterogeneity and intra-chromatin connectivity in cancer cells. Also see the related Primer by Daniel Holoch and Raphaël Margueron.
Image credit: pbio.3003191
06/12/2025
Methods and Resources
Most genetic screens characterize host factors important for the early stages of viral infection. Xin Yin, Yuan Pu, Laura Martin-Sancho, Sumit Chanda and colleagues use a genome-scale siRNA screen to uncover key pathways influencing both early and late stages of infection, including the non-canonical NF-κB pathway.
Image credit: pbio.3002738
06/10/2025
Research Article
Gaowei Jin, Joaquín Campos, Yang Liu, Fredrik Sterky, Claudio Acuna, Zhiyi Wei and co-workers solve the crystal structure of the liprin-α2/RIM1 complex and show that this interaction is essential for synaptic transmission and the coupling of calcium channels with primed synaptic vesicles in an LLPS-dependent manner. Don't miss the Primer by Janine Lützkendorf and Stephan Sigrist.
Image credit: pbio.3002817
06/09/2025
Research Article
Effects of variants at one gene can be modified by variants at other loci; an example is the FLC gene which helps determine flowering time variation in Arabidopsis thaliana. This analysis of FLC mutants across 62 natural genetic backgrounds, by Ulrich Lutz, Detlef Weigel and colleagues, showcases the potential of pan-genetic analysis of hub genes to reveal the extent of their broader genetic network.
Image credit: pbio.3003226
06/05/2025
Short Report
Androgen receptor-positive prostate cancer cells abundantly express hormone-dependent tRNA halves, but their functions are unclear. Takuya Kawamura, Megumi Shigematsu and Yohei Kirino show that the 5′-tRNALysCUU half promotes cell cycle progression by destabilizing the mRNA of p21, a negative regulator, suggesting a general role for these molecules.
Image credit: pbio.3003194
06/11/2025
Essay
The relationship between migraine aura and headache has been the subject of a long-standing debate. This Essay delves into the mechanistic and pathophysiological links between migraine aura and headache.
Image credit: pbio.3003168
06/10/2025
Perspective
Can AI become a true scientist? Nina Miolane explores how new technologies are reshaping scientific discovery, and why human expertise remains essential as we enter a new era of research powered by intelligent algorithms.
Image credit: pbio.3003230
05/20/2025
Perspective
Increasing concerns over the welfare of captive cetaceans have led to calls for their transfer to sanctuaries. This Perspective describes an unprecedented collaboration to develop the first accreditation guidelines for authentic ocean sanctuaries.
Image credit: pbio.3003166
05/15/2025
Perspective
To what extent can we predict future pathogenic microbes? Arturo Casadevall discusses why complex requirements for virulence and dynamic host-microbe interactions make probabilistic predictions difficult, but not impossible.
Image credit: pbio.3003162
Neurotechnology offers unprecedented opportunities to treat neural disorders, restore brain function and enhance cognitive abilities. This collection explores the present and possible futures of neurotechnology to improve human health and cognition.
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
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Meet Senior Editor Roli Roberts (rroberts@plos.org)
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