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Mapping Insecticide-Resistant Mosquitoes

June 25, 2020

Mapping Insecticide-Resistant Mosquitoes

Penelope Hancock, Catherine Moyes and co-workers provide fine-resolution maps of insecticide resistance levels in malaria vectors for large parts of Sub-Saharan Africa; these quantify recent spatial trends and can inform implementation of management practices.

Image credit: Wikimedia Commons User CaptNemoZum

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology

PLOS Biologue

06/25/2020

Research Article

NCX1 and Sodium Sensing in Macrophages

Inflammation and infection can trigger local tissue accumulation of Na+ ions, boosting pro-inflammatory antimicrobial activity of monocyte/macrophage-like cells. Patrick Neubert, Arne Homann, David Wendelborn, Jonathan Jantsch and colleagues show that the sensing of Na+ ions by macrophages requires the Na+/Ca2+ exchanger NCX1.

Image credit: pbio.3000722

NCX1 and Sodium Sensing in Macrophages

Recently Published Articles

Current Issue

Current Issue June 2020

06/19/2020

Research Article

Extruding Bacterial Amyloids

Curli are functional amyloids that play critical roles in biofilm formation and adhesion in many Enterobacteriaceae. Two outer membrane proteins, CsgG and CsgF, form the core apparatus for secretion and assembly of the curli structural subunits. The cryo-EM structure of the CsgG-CsgF complex, by Manfeng Zhang, Huigang Shi, Xuemei Zhang, Xinzheng Zhang and Yihua Huang, reveals a unique amyloid secretion channel with two tandem constriction regions.

Image credit: pbio.3000748

Extruding Bacterial Amyloids

06/19/2020

Research Article

Dopamine Modulates Response to Surprising Sounds

Information about unexpected stimuli is encoded in the form of prediction error signals. The earliest prediction error signals identified in the auditory brain emerge subcortically in the inferior colliculus. Catalina Valdés-Baizabal, Guillermo Carbajal, David Pérez-González and Manuel Malmierca reveal the essential role of dopamine in encoding the precision of prediction errors at the auditory midbrain.

Image credit: pbio.3000744

Dopamine Modulates Response to Surprising Sounds

06/18/2020

Short Reports

Centriolar Satellites and the Cilium

By redistributing centriolar satellites to the periphery or center of the cell, Özge Aydin, Sevket Onur Taflan, Can Gurkaslar and Elif Nur Firat-Karalar reveal novel functions for satellites during mitosis, cilium maintenance, and cilium disassembly, suggesting novel mechanisms.

Centriolar Satellites and the Cilium

Image credit: pbio.3000679

06/12/2020

Short Report & PRIMER

Thinking of Others...

Why do we like seeing good things happen to others? Benjamin Basile, Elisabeth Murray and co-workers use a study of rhesus monkeys playing a juice donation game to show that the anterior cingulate cortex is necessary for monkeys to acquire normal prosocial preferences. Also read the accompanying Primer by Patricia Lockwood, Kathryn O'Nell and Matthew Apps.

Thinking of Others...

Image credit: pbio.3000735

06/10/2020

Methods and Resources

How Mitochondria Drive Trypanosome Development

Eva Doleželová, Alena Zíková and co-workers reveal that developmental progression of the human parasite Trypanosoma brucei is accompanied by dynamic metabolic remodeling of its mitochondrion, leading to increased production of reactive oxygen species; these are found to act as essential cellular signals, driving the parasite's differentiation.

How Mitochondria Drive Trypanosome Development

Image credit: pbio.3000741

06/10/2020

Research Article

Tumor-Infiltrating Macrophages and the UPR

Tumor-infiltrating macrophages have an active UPR and a mixed proinflammatory and immune-suppressive phenotype. This is driven by the IRE1a/Xbp1 axis of the UPR, so targeting the UPR may increase the response to immune checkpoint blockade therapy.

Tumor-Infiltrating Macrophages and the UPR

Image credit: Flickr user NIAID

06/09/2020

Research Article

Bacterial Multicellularity and Polysaccharides

A study of the social bacterium Myxococcus xanthus reveals that the bacteria preferentially secrete specific polysaccharides within distinct zones of a swarm to facilitate spreading across a surface.

Bacterial Multicellularity and Polysaccharides

Image credit: Omaima Rebay

06/09/2020

Research Article

A Humanised Mouse Model of Prion Disease

Transgenic mice expressing the human prion protein containing an inherited human prion disease mutation develop spontaneous neuropathology and mirror the generation of transmissible prion assemblies seen in humans. Also read the associated Primer.



A Humanised Mouse Model of Prion Disease

Image credit: pbio.3000725

06/09/2020

Research Article & PRIMER

Connecting Autophagy to the Cell Cycle

The ULK1-ATG13 autophagy initiation complex is differentially regulated throughout the cell cycle, especially in mitosis, promoting mitotic autophagy and cell cycle progression. Also read the accompanying Primer.

Connecting Autophagy to the Cell Cycle

Image credit: pbio.3000288

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