Advertisement
New, Improved Mammalian Tree of Life

December 4, 2019

New, Improved Mammalian Tree of Life

Nathan Upham, Jacob Esselstyn and Walter Jetz present a newly robust evolutionary timescale for ~6000 extant species of mammals, aimed at understanding their species-specific rates of diversification and distinct phylogenetic history. Ages and relationships in the tree of life are estimated with probabilistic confidence levels to help future tests of eco-evolutionary hypotheses.

Image credit: pbio.3000494

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology

PLOS Biologue

12/02/2019

Research Article

JAM-C Trafficking and Endothelial Cell Migration

Katja Kostelnik, Amy Barker, Thomas Nightingale and colleagues use a novel proximity-labelling proteomic approach, together with light and electron microscopy in primary endothelial cells, to reveal the crucial role of receptor trafficking and ubiquitylation in the function of the junctional adhesion molecule JAM-C; dynamic trafficking of this receptor is essential for normal endothelial cell migration.

Image credit: pbio.3000554

JAM-C Trafficking and Endothelial Cell Migration

Recently Published Articles

Current Issue

Current Issue November 2019

12/05/2019

Research Article

Intestinal Cues Regulates Neural Serotonin Signaling

As a neuromodulator, serotonin regulates numerous behavioral and emotional states. Aude Bouagnon, Kaveh Ashrafi and co-workers show in the nematode Caenorhabditis elegans that metabolic cues originating in the organism's periphery modulate neurally regulated serotonergic processes, including feeding behavior and egg laying, revealing a homeostatic signal that informs the nervous system of the organism's nutritional state.

Image credit: pbio.3000242

Intestinal Cues Regulates Neural Serotonin Signaling

12/05/2019

Research Article

Three-Way Junction Molecule Sidekick Helps Cell Intercalation

Tara M. Finegan, Nathan Hervieux, Bénédicte Sanson and colleagues identify the adhesion molecule Sidekick as a resident protein of tricellular vertices between cells, at the level of adherens junctions. A combination of quantitative methods and modelling provides evidence that Sidekick facilitates polarised cell intercalation during Drosophila axis extension.

Image credit: pbio.3000522

Three-Way Junction Molecule Sidekick Helps Cell Intercalation

12/05/2019

Research Article

Communicating Danger

Yingying Han, Rune Bruls, Maria Carrillo, Christian Keysers and co-authors show that when one rat witnesses another receive electric shocks, the rats transfer information in both directions. Simulations show that a phenomenon typically associated with empathy and prosociality may actually have evolved to serve the more selfish purpose of danger detection.

Communicating Danger

Image credit: Christian Keysers

12/04/2019

Research Article

Endo-Lysosome Expansion in Activated Phagocytes

Activation of phagocytes rapidly expands the endo-lysosomal system and promotes antigen presentation. Victoria Hipolito, Roberto Botelho and colleagues find that endo-lysosome expansion was driven by mTORC1-dependent enhanced translation, revealing regulated translation as a mechanism to remodel membrane organelles in response to external signals and stresses.

Endo-Lysosome Expansion in Activated Phagocytes

Image credit: pbio.3000535

12/05/2019

Research Article

Mediator MED23 and Liver Fibrosis

Liver fibrosis is characterized by hepatic damage, an inflammatory response, and hepatic stellate cell activation, but the underlying mechanisms remain unclear. Zhichao Wang, Dan Cao, Gang Wang and co-workers reveal that the transcriptional Mediator subunit MED23 regulates the pathogenesis of liver fibrosis by controlling the production of inflammatory cytokines such as CCL5 and CXCL10.

Mediator MED23 and Liver Fibrosis

Image credit: pbio.3000563

12/03/2019

Research Article

Transcription-Induced Extrachromosomal DNA

Transcription can cause the de novo formation of protein-coding extrachromosomal circular DNA (eccDNA) that accumulates in aging yeast cells; these eccDNA molecules form frequently by a DNA double strand break repair mechanism.

Transcription-Induced Extrachromosomal DNA

Image credit: pbio.3000471

12/05/2019

Essay

Why the Menopause?

This Essay proposes that existing adaptive explanations for the menopause have underestimated an important factor operating both at the specific and the individual levels: the balance between cancer risks and cancer defences.


Why the Menopause?

Image credit: pbio.3000565

12/05/2019

Research Article

The Dynamics of Feeding Behaviour

A quantitative study of rodent feeding behaviour reveals that anorectic agents may have substantially different behavioural effects from one another. In silico studies suggest alternative strategies for reducing food intake.

The Dynamics of Feeding Behaviour

Image credit: pbio.3000482

12/03/2019

Research Article

Non-Independence of Co-Infection

If pathogen species, strains, or clones do not interact, intuition suggests the proportion of coinfected hosts can be obtained by simply multiplying the individual prevalences. However, even simple epidemiological models show this to be untrue.

Non-Independence of Co-Infection

Image credit: pbio.3000551

Get new content from PLOS Biology in your inbox

Thank you! You have successfully subscribed to the PLOS Biology newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

Try again