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Intact but Empty Forests?

May 14, 2019

Intact but Empty Forests?

Ana Benítez-López, Mark Huijbregts and co-workers estimate that roughly half of the tropics contain defaunated populations of medium and large mammal species as a result of hunting pressure; hunting effects are so pervasive that even intact forests and wilderness areas are becoming empty of mammal populations.

Image credit: Flickr Brian Ralphs

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PLOS Biology's XV Collection

05/10/2019

Research Article

Cyclic AMP and Malaria Invasion

Avnish Patel, Abigail Perrin, Michael Blackman, David Baker and colleagues use conditional gene knockout to show that cyclic AMP signalling is absolutely required for invasion of erythrocytes by malaria parasites. Quantitative mass spectrometry identifies the parasite proteins whose phosphorylation is adversely affected when cyclic AMP signalling is ablated.

Image credit: pbio.3000264

Cyclic AMP and Malaria Invasion

Recently Published Articles

Current Issue

Current Issue April 2019

05/13/2019

Research Article

Malaria's Invisibility Cloak

Malaria parasites have a remarkable capacity to continuously generate genetically diverse surface antigens, helping them to evade the host immune response. Xu Zhang, Kirk Deitsch and co-authors reveal the unusual recombination mechanism which accelerates the diversification of this gene family in Plasmodium falciparum, the most severe of the human malarial parasites.

Image credit: Flickr Mario Yordanov

Malaria's Invisibility Cloak

05/13/2019

Short Reports

Mutation Bias and TB

Some types of mutations occur more frequently than expected. Joshua Payne, Fabrizio Menardo, Sebastien Gagneux, Alex Hall and co-authors show that such bias — an excess of transitions over transversions — influences the evolution of antibiotic resistance in a key global pathogen, Mycobacterium tuberculosis.


Image credit: Flickr NIAID

Mutation Bias and TB

05/13/2019

Research Article

Transporting Organic Anions

The first structures of a family of organic anion transporters, by Jonathan Leano, Robert Stroud, Robert Edwards and colleagues reveal an interaction with protons that is conserved from bacterial transporters to the mammalian proteins that transport glutamate into synaptic vesicles.

Transporting Organic Anions

Image credit: pbio.3000260

05/16/2019

Methods and Resources

CLEVR Tracking of Endogenous Retroviral Activity

Using gypsy elements in aging fruit flies, Yung-Heng Chang, Richard Keegan, Lisa Prazak and Josh Dubnau describe cellular labelling of endogenous retrovirus replication (CLEVR), an in vivo reporter system that allows the tracing of virus or LTR retrotransposon replication in tissues.


CLEVR Tracking of Endogenous Retroviral Activity

Image credit: pbio.3000278

05/14/2019

Research Article

The Architecture of Drosophila Centromeres

Ching-Ho Chang, Ankita Chavan, Jason Palladino, Amanda Larracuente, Barbara Mellone and co-authors use long-read sequencing, CENP-A ChIP, and chromatin fiber imaging to reveal the composition and organization of Drosophila melanogaster centromeres, which have long remained elusive despite the high quality of this species’ genome assembly.

The Architecture of Drosophila Centromeres

Image credit: pbio.3000241

05/14/2019

Research Article

Lysosomes, Starvation and Recovery

HLH-30, the nematode orthologue of the mammalian MiT/TFE family of master regulators of lysosome biogenesis, plays a key role in survival under starvation and refeeding conditions.

Lysosomes, Starvation and Recovery

Image credit: pbio.3000245

05/14/2019

Research Article

Keeping Macrophages at Wounds

Uncleared apoptotic cells impair macrophage dispersal and wound responses, revealing a role for the receptor Simu in phagocytosis of necrotic cells and retention of macrophages at wounds.

Keeping Macrophages at Wounds

Image credit: pbio.2006741

05/16/2019

Research Article

Do Point-of-Care Resistance Diagnostics Help?

Conditioning antimicrobial treatment protocols on both point-of-care and carriage diagnostics can produce effective patient care that also selects against resistance.

Do Point-of-Care Resistance Diagnostics Help?

Image credit: Pixabay

05/10/2019

Primer

Evolution of the cortical Connectome

Miguel Ángel García-Cabezas and Basilis Zikopoulos explore recent research into the common organizational principles and specializations of the cerebral cortex. Read the related Research Article.

Evolution of the cortical Connectome

Image credit: pbio.2005346

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