06/30/2022
Research Article
Human embryos develop poorly in vitro, and as much as 60% of embryos will irreversibly arrest. Yang Yang, Liyang Shi, Andrew Hutchins, Guoqing Tong and colleagues show that the arrested embryos enter a senescent-like state; several mechanisms related to zygotic genome activation problems and erroneous metabolism can explain some of the reasons behind this arrest.
Image credit: pbio.3001682
Current IssueJune 2022
06/30/2022
Methods and Resources
Mengwen Zhang, Mark Hochstrasser and co-workers present OtUBD, a new tool derived from a bacterial deubiquitylase, for the purification and analysis of a broad range of endogenous ubiquitylated proteins, including monoubiquitylation, polyubiquitylation, non-lysine ubiquitylation and potentially other macromolecules.
Image credit: pbio.3001501
06/29/2022
Essay
Where did RNA interference come from? Alessandro Torri, Maria-Carla Saleh and co-authors describe a new step-by-step evolutionary model of how RNA interference might have originated in early eukaryotes through neutral events from the molecular machinery present in prokaryotes.
Image credit: pbio.3001715
06/28/2022
Primer
Brett Foster and Eleonora Bartoli explore the implications of a recent PLOS Biology study showing that gamma synchrony in visual cortex is disrupted when small discontinuities are added to visual stimuli. This suggests that gamma synchrony is highly sensitive to regularities in the visual world and potentially plays a role in predictive processing.
Image credit: pbio.3001701
06/28/2022
Community Page
Connor Wood, Holger Klinck and co-authors argue that involving the general public in research through free bird sound identification apps such as BirdNET can generate tens of millions of bird observations globally, helping citizen science to power avian ecology.
Image credit: pbio.3001670
06/23/2022
Short Reports
Snake fungal disease is emerging in eastern North America, but its origins have been unclear. Jason Ladner, Jeffrey Lorch and colleagues use population genetic data to show that the fungus that causes the disease was introduced multiple times to North America over the last few hundred years.
Image credit: pbio.3001676
06/22/2022
Methods and Resources
A compilation of infectious disease transmission trees enables analysis of trends in superspreader frequency and generation, suggesting that superspreaders beget other superspreaders.
Image credit: pbio.3001685
06/21/2022
Research Article
Response to acute oxygen shortage is crucial for aerobic life, but its molecular mechanisms are poorly understood. This study reveals that high levels of cGMP and ROS prevent the nematode C. elegans from escaping hypoxia.
Image credit: pbio.3001684
06/21/2022
Research Article
An unbiased genome-scale approach reveals multiple Staphylococcus aureus secreted factors that are sensed by co-infecting pathogen Pseudomonas aeruginosa.
Image credit: Erina He, NIH Medical Arts
06/16/2022
Perspective
The integration of authentic research in tropical biology could promote internationality among scientists and provide experiential learning that enables students to address complex global problems.
Image credit: J. Leighton Reid
Raquel Lieberman discusses her work on the protein myocilin, implicated in glaucoma, but whose normal function remains unclear after over 20 years.
Susanna Bidgood explores the future of using poxviruses as versatile tools for cell biology research.
Rachel Harding proposes that open notebooks present an opportunity for researchers to showcase their work and rapidly advance science in their field
On the eve of the UN General Assembly meeting on TB, Christoph Grundner urged the need to consider basic research as an essential component of any future anti-TB strategy.
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
July 5-7
Meet Editor in Chief Nonia Pariente
July 17-21
Meet Associate Editor Richard Hodge
August 7-12
Meet Senior Editor Kris Dickson
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