Advertisement
Table of Contents

June 2019

Macrophage (white) hosting Leishmania amazonensis (red, parasite nuclei and kinetoplasts in orange) that multiply in spacious, large parasitophorous vacuoles (PVs). The volumetric expansion of PVs is controlled by different host cell factors, among which the d2 variant of V-ATPase subunit d (ATP6V0d2). Picture obtained from confocal images of immunostained samples (for host macrophage lysosomes using anti-Lamp-1 antibody and parasite surface using 2A3-26 antibody) and reconstructed in three-dimensional image. Pessoa et al.

Research Articles

Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism

Juntao Liu, Lihui Zhu, Jianbin Wang, Lin Qiu, Yongjun Chen, Richard E. Davis, Guofeng Cheng

Multidimensional analysis of Gammaherpesvirus RNA expression reveals unexpected heterogeneity of gene expression

Lauren M. Oko, Abigail K. Kimball, Rachael E. Kaspar, Ashley N. Knox, Carrie B. Coleman, Rosemary Rochford, Tim Chang, Benjamin Alderete, Linda F. van Dyk, Eric T. Clambey

Potent neutralizing antibodies elicited by dengue vaccine in rhesus macaque target diverse epitopes

Leike Li, Weixu Meng, Melanie Horton, Daniel R. DiStefano, Elizabeth A. Thoryk, Jennifer M. Pfaff, Qihui Wang, Georgina T. Salazar, Trevor Barnes, Benjamin J. Doranz, Andrew J. Bett, Danilo R. Casimiro, Kalpit A. Vora, Zhiqiang An, Ningyan Zhang

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

Barbara H. Stokes, Euna Yoo, James M. Murithi, Madeline R. Luth, Pavel Afanasyev, Paula C. A. da Fonseca, Elizabeth A. Winzeler, Caroline L. Ng, Matthew Bogyo, David A. Fidock

An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion

L. Brock Thornton, Paige Teehan, Katherine Floyd, Christian Cochrane, Amy Bergmann, Bryce Riegel, Andrew J. Stasic, Manlio Di Cristina, Silvia N. J. Moreno, Paul D. Roepe, Zhicheng Dou

An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS)

Lan Lin, Lei Xu, Weihua Lv, Li Han, Yaozu Xiang, Lei Fu, Meilin Jin, Rui Zhou, Huanchun Chen, Anding Zhang

A bacterial secreted translocator hijacks riboregulators to control type III secretion in response to host cell contact

Maria Kusmierek, Jörn Hoßmann, Rebekka Witte, Wiebke Opitz, Ines Vollmer, Marcel Volk, Ann Kathrin Heroven, Hans Wolf-Watz, Petra Dersch

Natural Immunity to HIV is associated with Low BLyS/BAFF levels and low frequencies of innate marginal zone like CD1c+ B-cells in the genital tract

Lyvia Fourcade, Catherine Sabourin-Poirier, Victoire Perraud, Marie-Claude Faucher, Josiane Chagnon-Choquet, Annie-Claude Labbé, Michel Alary, Fernand Guédou, Johanne Poudrier, Michel Roger

The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis

Liwen Deng, Brady L. Spencer, Joshua A. Holmes, Rong Mu, Sara Rego, Thomas A. Weston, Yoonsung Hu, Glenda F. Sanches, Sunghyun Yoon, Nogi Park, Prescilla E. Nagao, Howard F. Jenkinson, Justin A. Thornton, Keun Seok Seo, Angela H. Nobbs, Kelly S. Doran

The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance

Wenjuan Du, Hongbo Guo, Vera S. Nijman, Jennifer Doedt, Erhard van der Vries, Joline van der Lee, Zeshi Li, Geert-Jan Boons, Frank J. M. van Kuppeveld, Erik de Vries, Mikhail Matrosovich, Cornelis A. M. de Haan

Fimbriae reprogram host gene expression – Divergent effects of P and type 1 fimbriae

Ines Ambite, Daniel S. C. Butler, Christoph Stork, Jenny Grönberg-Hernández, Bela Köves, Jaroslaw Zdziarski, Jerome Pinkner, Scott J. Hultgren, Ulrich Dobrindt, Björn Wullt, Catharina Svanborg

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites

Ellen Knuepfer, Katherine E. Wright, Surendra Kumar Prajapati, Thomas A. Rawlinson, Franziska Mohring, Marion Koch, Oliver R. Lyth, Steven A. Howell, Elizabeth Villasis, Ambrosius P. Snijders, Robert W. Moon, Simon J. Draper, Anna Rosanas-Urgell, Matthew K. Higgins, Jake Baum, Anthony A. Holder

BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues

Isabelle C. Arnold, Xiaozhou Zhang, Mariela Artola-Boran, Angela Fallegger, Peter Sander, Pål Johansen, Anne Müller

Functional paralysis of human natural killer cells by alphaherpesviruses

Tessa Mollie Campbell, Brian Patrick McSharry, Megan Steain, Tiffany Ann Russell, David Carl Tscharke, Jarrod John Kennedy, Barry Slobedman, Allison Abendroth

Therapeutic efficacy of favipiravir against Bourbon virus in mice

Traci L. Bricker, Md. Shafiuddin, Anshu P. Gounder, Andrew B. Janowski, Guoyan Zhao, Graham D. Williams, Brett W. Jagger, Michael S. Diamond, Thomas Bailey, Jennie H. Kwon, David Wang, Adrianus C. M. Boon

Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies

Panpan Zhou, Han Wang, Mengqi Fang, Yangyang Li, Hua Wang, Shasha Shi, Zihao Li, Jiapeng Wu, Xiaoxu Han, Xuanling Shi, Hong Shang, Tongqing Zhou, Linqi Zhang

An autoinducer-independent RhlR quorum-sensing receptor enables analysis of RhlR regulation

Amelia R. McCready, Jon E. Paczkowski, Jian-Ping Cong, Bonnie L. Bassler

TLR11-independent inflammasome activation is critical for CD4+ T cell-derived IFN-γ production and host resistance to Toxoplasma gondii

Américo H. López-Yglesias, Ellie Camanzo, Andrew T. Martin, Alessandra M. Araujo, Felix Yarovinsky

ATP6V0d2 controls Leishmania parasitophorous vacuole biogenesis via cholesterol homeostasis

Carina Carraro Pessoa, Luiza Campos Reis, Eduardo Milton Ramos-Sanchez, Cristina Mary Orikaza, Cristian Cortez, Erica Valadares de Castro Levatti, Ana Carolina Benites Badaró, Joyce Umbelino da Silva Yamamoto, Vânia D’Almeida, Hiro Goto, Renato Arruda Mortara, Fernando Real

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery

Benjamin Götte, Marc D. Panas, Kirsi Hellström, Lifeng Liu, Baila Samreen, Ola Larsson, Tero Ahola, Gerald M. McInerney

Rab32 GTPase, as a direct target of miR-30b/c, controls the intracellular survival of Burkholderia pseudomallei by regulating phagosome maturation

Zhi-qiang Hu, Cheng-long Rao, Meng-ling Tang, Yu zhang, Xiao-xue Lu, Jian-gao Chen, Chan Mao, Ling Deng, Qian Li, Xu-hu Mao

DNA methylation from a Type I restriction modification system influences gene expression and virulence in Streptococcus pyogenes

Taylor M. Nye, Kristin M. Jacob, Elena K. Holley, Juan M. Nevarez, Suzanne Dawid, Lyle A. Simmons, Michael E. Watson Jr.

The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegans

Sarah M. Anderson, Hilary K. Cheesman, Nicholas D. Peterson, J. Elizabeth Salisbury, Alexander A. Soukas, Read Pukkila-Worley

The Orthotospovirus nonstructural protein NSs suppresses plant MYC-regulated jasmonate signaling leading to enhanced vector attraction and performance

Xiujuan Wu, Shuang Xu, Pingzhi Zhao, Xuan Zhang, Xiangmei Yao, Yanwei Sun, Rongxiang Fang, Jian Ye

Systems analysis of subjects acutely infected with the Chikungunya virus

Alessandra Soares-Schanoski, Natália Baptista Cruz, Luíza Antunes de Castro-Jorge, Renan Villanova Homem de Carvalho, Cliomar Alves dos Santos, Nancy da Rós, Úrsula Oliveira, Danuza Duarte Costa, Cecília Luíza Simões dos Santos, Marielton dos Passos Cunha, Maria Leonor Sarno Oliveira, Juliana Cardoso Alves, Regina Adalva de Lucena Couto Océa, Danielle Rodrigues Ribeiro, André Nicolau Aquime Gonçalves, Patricia Gonzalez-Dias, Andreas Suhrbier, Paolo Marinho de Andrade Zanotto, Inácio Junqueira de Azevedo, Dario S. Zamboni, Roque Pacheco Almeida, Paulo Lee Ho, Jorge Kalil, Milton Yutaka Nishiyama Junior, Helder I. Nakaya

Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion

Amy C. Pickering, Pauline Vitry, Valeriia Prystopiuk, Brandon Garcia, Magnus Höök, Jeffrey Schoenebeck, Joan A. Geoghegan, Yves F. Dufrêne, J. Ross Fitzgerald

Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8

Chenggong Ji, Shuo Du, Peng Li, Qinyu Zhu, Xiaoke Yang, Chunhong Long, Jin Yu, Feng Shao, Junyu Xiao

NK cell–intrinsic FcεRIγ limits CD8+ T-cell expansion and thereby turns an acute into a chronic viral infection

Vikas Duhan, Thamer A. Hamdan, Haifeng C. Xu, Prashant Shinde, Hilal Bhat, Fanghui Li, Yahya Al-Matary, Dieter Häussinger, Judith Bezgovsek, Sarah-Kim Friedrich, Cornelia Hardt, Philipp A. Lang, Karl S. Lang

Related Articles

Comparison of intra- and inter-host genetic diversity in rabies virus during experimental cross-species transmission

Emilie M. Bonnaud, Cécile Troupin, Laurent Dacheux, Edward C. Holmes, Elodie Monchatre-Leroy, Marion Tanguy, Christiane Bouchier, Florence Cliquet, Jacques Barrat, Hervé Bourhy

Killing from the inside: Intracellular role of T3SS in the fate of Pseudomonas aeruginosa within macrophages revealed by mgtC and oprF mutants

Preeti Garai, Laurence Berry, Malika Moussouni, Sophie Bleves, Anne-Béatrice Blanc-Potard

Blowing epithelial cell bubbles with GumB: ShlA-family pore-forming toxins induce blebbing and rapid cellular death in corneal epithelial cells

Kimberly M. Brothers, Jake D. Callaghan, Nicholas A. Stella, Julianna M. Bachinsky, Mohammed AlHigaylan, Kara L. Lehner, Jonathan M. Franks, Kira L. Lathrop, Elliot Collins, Deanna M. Schmitt, Joseph Horzempa, Robert M. Q. Shanks

Vaccinia viral A26 protein is a fusion suppressor of mature virus and triggers membrane fusion through conformational change at low pH

Hung-Wei Chang, Cheng-Han Yang, Yu-Chun Luo, Bo-Gang Su, Huei-Yin Cheng, Shu-Yun Tung, Kathleen Joyce D. Carillo, Yi-Ting Liao, Der-Lii M. Tzou, Hao-Ching Wang, Wen Chang

Neutrophil and macrophage influx into the central nervous system are inflammatory components of lethal Rift Valley fever encephalitis in rats

Joseph R. Albe, Devin A. Boyles, Aaron W. Walters, Michael R. Kujawa, Cynthia M. McMillen, Douglas S. Reed, Amy L. Hartman

Proliferative memory SAMHD1low CD4+ T cells harbour high levels of HIV-1 with compartmentalized viral populations

Lylia Hani, Antoine Chaillon, Marie-Laure Nere, Nicolas Ruffin, Joudy Alameddine, Maud Salmona, José-Luiz Lopez Zaragoza, Davey M. Smith, Olivier Schwartz, Jean-Daniel Lelièvre, Constance Delaugerre, Yves Lévy, Nabila Seddiki

Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia

Nico A. Contreras, Katarzyna M. Sitnik, Ilija Jeftic, Christopher Patrick Coplen, Luka Čičin-Šain, Janko Nikolich-Žugich

EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis

Fengchao Lang, Rajnish Kumar Singh, Yonggang Pei, Shengwei Zhang, Kunfeng Sun, Erle S. Robertson

Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens

Roberto Gozalbo-Rovira, J. Rafael Ciges-Tomas, Susana Vila-Vicent, Javier Buesa, Cristina Santiso-Bellón, Vicente Monedero, María J. Yebra, Alberto Marina, Jesús Rodríguez-Díaz

The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming

Aline Sardinha-Silva, Flávia C. Mendonça-Natividade, Camila F. Pinzan, Carla D. Lopes, Diego L. Costa, Damien Jacot, Fabricio F. Fernandes, André L. V. Zorzetto-Fernandes, Nicholas J. Gay, Alan Sher, Dragana Jankovic, Dominique Soldati-Favre, Michael E. Grigg, Maria Cristina Roque-Barreira

The YIN and YANG of lipoproteins in developing and preventing infectious arthritis by Staphylococcus aureus

Majd Mohammad, Minh-Thu Nguyen, Cecilia Engdahl, Manli Na, Anders Jarneborn, Zhicheng Hu, Anna Karlsson, Rille Pullerits, Abukar Ali, Friedrich Götz, Tao Jin

Non-canonical NLRP3 inflammasome activation and IL-1β signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4

Mariana M. Chaves, Debora A. Sinflorio, Maria Luiza Thorstenberg, Monique Daiane Andrade Martins, Aline Cristina Abreu Moreira-Souza, Thuany Prado Rangel, Claudia L. M. Silva, Maria Bellio, Claudio Canetti, Robson Coutinho-Silva

Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection

Barbara A. Bensing, Liang Li, Olga Yakovenko, Maurice Wong, Karen N. Barnard, T. M. Iverson, Carlito B. Lebrilla, Colin R. Parrish, Wendy E. Thomas, Yan Xiong, Paul M. Sullam

Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections

Tom Beneke, François Demay, Edward Hookway, Nicole Ashman, Heather Jeffery, James Smith, Jessica Valli, Tomas Becvar, Jitka Myskova, Tereza Lestinova, Shahaan Shafiq, Jovana Sadlova, Petr Volf, Richard John Wheeler, Eva Gluenz

A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III

Dan Hu, Zhongyu Zhu, Shun Li, Yongqiang Deng, Yanling Wu, Nana Zhang, Vinita Puri, Chunyu Wang, Peng Zou, Cheng Lei, Xiaolong Tian, Yulu Wang, Qi Zhao, Wei Li, Ponraj Prabakaran, Yang Feng, Jane Cardosa, Chengfeng Qin, Xiaohui Zhou, Dimiter S. Dimitrov, Tianlei Ying

The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors

Aiysha Thompson, Luke C. Davies, Chia-Te Liao, Diogo M. da Fonseca, James S. Griffiths, Robert Andrews, Adam V. Jones, Mathew Clement, Gordon D. Brown, Ian R. Humphreys, Philip R. Taylor, Selinda J. Orr

Enteropathogenic Escherichia coli remodels host endosomes to promote endocytic turnover and breakdown of surface polarity

Ephrem G. Kassa, Efrat Zlotkin-Rivkin, Gil Friedman, Rachana P. Ramachandran, Naomi Melamed-Book, Aryeh M. Weiss, Michael Belenky, Dana Reichmann, William Breuer, Ritesh Ranjan Pal, Ilan Rosenshine, Lynne A. Lapierre, James R. Goldenring, Benjamin Aroeti

Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus

Naomi M. Walsh, Michael R. Botts, Andrew J. McDermott, Sébastien C. Ortiz, Marcel Wüthrich, Bruce Klein, Christina M. Hull

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila

Augusto V. Gonçalves, Shally R. Margolis, Gustavo F. S. Quirino, Danielle P. A. Mascarenhas, Isabella Rauch, Randilea D. Nichols, Eduard Ansaldo, Mary F. Fontana, Russell E. Vance, Dario S. Zamboni

EspF is crucial for Citrobacter rodentium-induced tight junction disruption and lethality in immunocompromised animals

Xue Xia, Yue Liu, Andrea Hodgson, Dongqing Xu, Wenxuan Guo, Hongbing Yu, Weifeng She, Chenxing Zhou, Lei Lan, Kai Fu, Bruce A. Vallance, Fengyi Wan

HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I

Amanda W. Rushing, Blake Rushing, Kimson Hoang, Stephanie V. Sanders, Jean-Marie Péloponèse Jr., Nicholas Polakowski, Isabelle Lemasson

Corrections

Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

Allison F. Carey, Jeremy M. Rock, Inna V. Krieger, Michael R. Chase, Marta Fernandez-Suarez, Sebastien Gagneux, James C. Sacchettini, Thomas R. Ioerger, Sarah M. Fortune

Related Articles

Correction: A model of chronic, transmissible Otitis Media in mice

Kalyan K. Dewan, Dawn L. Taylor-Mulneix, Laura L. Campos, Amanda L. Skarlupka, Shannon M. Wagner, Valerie E. Ryman, Monica C. Gestal, Longhuan Ma, Uriel Blas-Machado, Brian T. Faddis, Eric T. Harvill

Related Articles