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August 2016

A striking image of the chlorovirus system, ranging in biology and size scale. We have studied this system at all of these levels for the past 35+ years to develop an evermore comprehensive understanding the viruses and their roles in biological systems. Van Etten et al,

Image Credit: Kit Lee

Opinion

Genome Skimming: A Rapid Approach to Gaining Diverse Biological Insights into Multicellular Pathogens

Dee R. Denver, Amanda M. V. Brown, Dana K. Howe, Amy B. Peetz, Inga A. Zasada

Research Matters

Life with Bacterial Secretion Systems

Tomoko Kubori

Research Articles

Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses

Matthew Zirui Tay, Pinghuang Liu, LaTonya D. Williams, Michael D McRaven, Sheetal Sawant, Thaddeus C Gurley, Thomas T. Xu, S. Moses Dennison, Hua-Xin Liao, Agnès-Laurence Chenine, S. Munir Alam, M. Anthony Moody, Thomas J. Hope, Barton F. Haynes, Georgia D. Tomaras

Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration

Irena Zurnic, Sylvia Hütter, Ute Rzeha, Nicole Stanke, Juliane Reh, Erik Müllers, Martin V. Hamann, Tobias Kern, Gesche K. Gerresheim, Fabian Lindel, Erik Serrao, Paul Lesbats, Alan N. Engelman, Peter Cherepanov, Dirk Lindemann

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Type I IFN Signaling Is Dispensable during Secondary Viral Infection

Martin P. Hosking, Claudia T. Flynn, J. Lindsay Whitton

Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus

Elizabeth R. Sturgill, Daniel Malouli, Scott G. Hansen, Benjamin J. Burwitz, Seongkyung Seo, Christine L. Schneider, Jennie L. Womack, Marieke C. Verweij, Abigail B. Ventura, Amruta Bhusari, Krystal M. Jeffries, Alfred W. Legasse, Michael K. Axthelm, Amy W. Hudson, Jonah B. Sacha, Louis J. Picker, Klaus Früh

The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing

Federico A. De Maio, Guillermo Risso, Nestor G. Iglesias, Priya Shah, Berta Pozzi, Leopoldo G. Gebhard, Pablo Mammi, Estefania Mancini, Marcelo J. Yanovsky, Raul Andino, Nevan Krogan, Anabella Srebrow, Andrea V. Gamarnik

An Essential Viral Transcription Activator Modulates Chromatin Dynamics

Rebecca L. Gibeault, Kristen L. Conn, Michael D. Bildersheim, Luis M. Schang

Overexpression of Differentially Expressed Genes Identified in Non-pathogenic and Pathogenic Entamoeba histolytica Clones Allow Identification of New Pathogenicity Factors Involved in Amoebic Liver Abscess Formation

Martin Meyer, Helena Fehling, Jenny Matthiesen, Stephan Lorenzen, Kathrin Schuldt, Hannah Bernin, Mareen Zaruba, Corinna Lender, Thomas Ernst, Harald Ittrich, Thomas Roeder, Egbert Tannich, Hannelore Lotter, Iris Bruchhaus

The Mutational Robustness of Influenza A Virus

Elisa Visher, Shawn E. Whitefield, John T. McCrone, William Fitzsimmons, Adam S. Lauring

Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators

Ye Ji Kim, Eui Tae Kim, Young-Eui Kim, Myoung Kyu Lee, Ki Mun Kwon, Keun Il Kim, Thomas Stamminger, Jin-Hyun Ahn

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design

Joseph G. Jardine, Devin Sok, Jean-Philippe Julien, Bryan Briney, Anita Sarkar, Chi-Hui Liang, Erin A. Scherer, Carole J. Henry Dunand, Yumiko Adachi, Devan Diwanji, Jessica Hsueh, Meaghan Jones, Oleksandr Kalyuzhniy, Michael Kubitz, Skye Spencer, Matthias Pauthner, Karen L. Saye-Francisco, Fabian Sesterhenn, Patrick C. Wilson, Denise M. Galloway, Robyn L. Stanfield, Ian A. Wilson, Dennis R. Burton, William R. Schief

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MoDnm1 Dynamin Mediating Peroxisomal and Mitochondrial Fission in Complex with MoFis1 and MoMdv1 Is Important for Development of Functional Appressorium in Magnaporthe oryzae

Kaili Zhong, Xiao Li, Xinyi Le, Xiangyi Kong, Haifeng Zhang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang

The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress

Jens Milbradt, Corina Hutterer, Hanife Bahsi, Sabrina Wagner, Eric Sonntag, Anselm H. C. Horn, Benedikt B. Kaufer, Yasuko Mori, Heinrich Sticht, Torgils Fossen, Manfred Marschall

Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1

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Evidence and Role for Bacterial Mucin Degradation in Cystic Fibrosis Airway Disease

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MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase

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Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs

Heng Giap Woon, Asolina Braun, Jane Li, Corey Smith, Jarem Edwards, Frederic Sierro, Carl G. Feng, Rajiv Khanna, Michael Elliot, Andrew Bell, Andrew D. Hislop, Stuart G. Tangye, Alan B. Rickinson, Thomas Gebhardt, Warwick J. Britton, Umaimainthan Palendira

The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells

Roger Badia, Maria Pujantell, Eva Riveira-Muñoz, Teresa Puig, Javier Torres-Torronteras, Ramón Martí, Bonaventura Clotet, Rosa M. Ampudia, Marta Vives-Pi, José A. Esté, Ester Ballana

The RNA Binding Specificity of Human APOBEC3 Proteins Resembles That of HIV-1 Nucleocapsid

Ashley York, Sebla B. Kutluay, Manel Errando, Paul D. Bieniasz

A Drosophila Model of HPV E6-Induced Malignancy Reveals Essential Roles for Magi and the Insulin Receptor

Mojgan Padash Barmchi, Mary Gilbert, Miranda Thomas, Lawrence Banks, Bing Zhang, Vanessa J. Auld

Jagged1 Instructs Macrophage Differentiation in Leprosy

Jon Kibbie, Rosane M. B. Teles, Zhiming Wang, Patrick Hong, Dennis Montoya, Stephan Krutzik, Seung Lee, Ohyun Kwon, Robert L. Modlin, Daniel Cruz

MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection

Sahana Holla, Praveen Prakhar, Vikas Singh, Anupama Karnam, Tanushree Mukherjee, Kasturi Mahadik, Pankti Parikh, Amit Singh, R. S. Rajmani, Subbaraya G. Ramachandra, Kithiganahalli Narayanaswamy Balaji

Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function

Matthew Pace, James Williams, Ayako Kurioka, Andrew B. Gerry, Bent Jakobsen, Paul Klenerman, Nneka Nwokolo, Julie Fox, Sarah Fidler, John Frater, CHERUB Investigators

Live-Cell Imaging of Vaccinia Virus Recombination

Patrick Paszkowski, Ryan S. Noyce, David H. Evans

The Invertebrate Lysozyme Effector ILYS-3 Is Systemically Activated in Response to Danger Signals and Confers Antimicrobial Protection in C. elegans

Maria João Gravato-Nobre, Filipa Vaz, Sergio Filipe, Ronald Chalmers, Jonathan Hodgkin

Exaptation of Bornavirus-Like Nucleoprotein Elements in Afrotherians

Yuki Kobayashi, Masayuki Horie, Ayumi Nakano, Koichi Murata, Takuya Itou, Yoshiyuki Suzuki

Importin β Can Bind Hepatitis B Virus Core Protein and Empty Core-Like Particles and Induce Structural Changes

Chao Chen, Joseph Che-Yen Wang, Elizabeth E. Pierson, David Z. Keifer, Mildred Delaleau, Lara Gallucci, Christian Cazenave, Michael Kann, Martin F. Jarrold, Adam Zlotnick

Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis

Hendrik Koliwer-Brandl, Karl Syson, Robert van de Weerd, Govind Chandra, Ben Appelmelk, Marina Alber, Thomas R. Ioerger, William R. Jacobs Jr., Jeroen Geurtsen, Stephen Bornemann, Rainer Kalscheuer

Virus Infection of Plants Alters Pollinator Preference: A Payback for Susceptible Hosts?

Simon C. Groen, Sanjie Jiang, Alex M. Murphy, Nik J. Cunniffe, Jack H. Westwood, Matthew P. Davey, Toby J. A. Bruce, John C. Caulfield, Oliver J. Furzer, Alison Reed, Sophie I. Robinson, Elizabeth Miller, Christopher N. Davis, John A. Pickett, Heather M. Whitney, Beverley J. Glover, John P. Carr

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An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens

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