New Paradigms to Help Solve the Global Aquaculture Disease Crisis

Grant D. Stentiford, Kallaya Sritunyalucksana, Timothy W. Flegel, Bryony A. P. Williams, Boonsirm Withyachumnarnkul, Orn Itsathitphaisarn, David Bass

PLOS Pathogens: published February 2, 2017 | https://doi.org/10.1371/journal.ppat.1006160

Environmental pH modulation by pathogenic fungi as a strategy to conquer the host

Slavena Vylkova

PLOS Pathogens: published February 23, 2017 | https://doi.org/10.1371/journal.ppat.1006149

A feast for Candida: Metabolic plasticity confers an edge for virulence

Pedro Miramón, Michael C. Lorenz

PLOS Pathogens: published February 9, 2017 | https://doi.org/10.1371/journal.ppat.1006144

They Might Be Giants: Does Syncytium Formation Sink or Spread HIV Infection?

Alex A. Compton, Olivier Schwartz

PLOS Pathogens: published February 2, 2017 | https://doi.org/10.1371/journal.ppat.1006099

Resolving host–pathogen interactions by dual RNA-seq

Alexander J. Westermann, Lars Barquist, Jörg Vogel

PLOS Pathogens: published February 16, 2017 | https://doi.org/10.1371/journal.ppat.1006033

Release of HIV-1 sequestered in the vesicles of oral and genital mucosal epithelial cells by epithelial-lymphocyte interaction

Aizezi Yasen, Rossana Herrera, Kristina Rosbe, Kathy Lien, Sharof M. Tugizov

PLOS Pathogens: published February 27, 2017 | https://doi.org/10.1371/journal.ppat.1006247

Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells

Mausumi Basu, Sean C. Courtney, Margo A. Brinton

PLOS Pathogens: published February 27, 2017 | https://doi.org/10.1371/journal.ppat.1006240

Nematode neuropeptides as transgenic nematicides

Neil D. Warnock, Leonie Wilson, Cheryl Patten, Colin C. Fleming, Aaron G. Maule, Johnathan J. Dalzell

PLOS Pathogens: published February 27, 2017 | https://doi.org/10.1371/journal.ppat.1006237

Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells

Yanlin Fan, Yusong R. Guo, Wang Yuan, Ying Zhou, Matthew V. Holt, Tao Wang, Borries Demeler, Nicolas L. Young, Weiwei Zhong, Yizhi J. Tao

PLOS Pathogens: published February 27, 2017 | https://doi.org/10.1371/journal.ppat.1006231

The transcriptome of HIV-1 infected intestinal CD4+ T cells exposed to enteric bacteria

Alyson C. Yoder, Kejun Guo, Stephanie M. Dillon, Tzu Phang, Eric J. Lee, Michael S. Harper, Karen Helm, John C. Kappes, Christina Ochsenbauer, Martin D. McCarter, Cara C. Wilson, Mario L. Santiago

PLOS Pathogens: published February 27, 2017 | https://doi.org/10.1371/journal.ppat.1006226

OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans

Beatriz Sierra, Petr Triska, Pedro Soares, Gissel Garcia, Ana B. Perez, Eglys Aguirre, Marisa Oliveira, Bruno Cavadas, Béatrice Regnault, Mayling Alvarez, Didye Ruiz, David C. Samuels, Anavaj Sakuntabhai, Luisa Pereira, Maria G. Guzman

PLOS Pathogens: published February 27, 2017 | https://doi.org/10.1371/journal.ppat.1006220

Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction

Ekaterina Maidji, Ma Somsouk, Jose M. Rivera, Peter W. Hunt, Cheryl A. Stoddart

PLOS Pathogens: published February 27, 2017 | https://doi.org/10.1371/journal.ppat.1006202

Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation

Vanessa C. McFadden, Rasha E. Shalaby, Saira Iram, Claudia E. Oropeza, Jennifer A. Landolfi, Alexander V. Lyubimov, Mark Maienschein-Cline, Stefan J. Green, Klaus H. Kaestner, Alan McLachlan

PLOS Pathogens: published February 24, 2017 | https://doi.org/10.1371/journal.ppat.1006239

Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1

Ramy El-Diwany, Valerie J. Cohen, Madeleine C. Mankowski, Lisa N. Wasilewski, Jillian K. Brady, Anna E. Snider, William O. Osburn, Ben Murrell, Stuart C. Ray, Justin R. Bailey

PLOS Pathogens: published February 24, 2017 | https://doi.org/10.1371/journal.ppat.1006235

Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo

Nirjal Bhattarai, James H. McLinden, Jinhua Xiang, M. Meleah Mathahs, Warren N. Schmidt, Thomas M. Kaufman, Jack T. Stapleton

PLOS Pathogens: published February 24, 2017 | https://doi.org/10.1371/journal.ppat.1006232

Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial

David Easterhoff, M. Anthony Moody, Daniela Fera, Hao Cheng, Margaret Ackerman, Kevin Wiehe, Kevin O. Saunders, Justin Pollara, Nathan Vandergrift, Rob Parks, Jerome Kim, Nelson L. Michael, Robert J. O’Connell, Jean-Louis Excler, Merlin L. Robb, Sandhya Vasan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Sorachai Nitayaphan, Faruk Sinangil, James Tartaglia, Sanjay Phogat, Thomas B. Kepler, S. Munir Alam, Hua-Xin Liao, Guido Ferrari, Michael S. Seaman, David C. Montefiori, Georgia D. Tomaras, Stephen C. Harrison, Barton F. Haynes

PLOS Pathogens: published February 24, 2017 | https://doi.org/10.1371/journal.ppat.1006182

Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A

Rodrigo Velázquez-Moctezuma, Mansun Law, Jens Bukh, Jannick Prentoe

PLOS Pathogens: published February 23, 2017 | https://doi.org/10.1371/journal.ppat.1006214

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function

Christine Burkard, Simon G. Lillico, Elizabeth Reid, Ben Jackson, Alan J. Mileham, Tahar Ait-Ali, C. Bruce A. Whitelaw, Alan L. Archibald

PLOS Pathogens: published February 23, 2017 | https://doi.org/10.1371/journal.ppat.1006206

A mouse model of paralytic myelitis caused by enterovirus D68

Alison M. Hixon, Guixia Yu, J. Smith Leser, Shigeo Yagi, Penny Clarke, Charles Y. Chiu, Kenneth L. Tyler

PLOS Pathogens: published February 23, 2017 | https://doi.org/10.1371/journal.ppat.1006199

Analysis of the T Cell Response to Zika Virus and Identification of a Novel CD8⁺ T Cell Epitope in Immunocompetent Mice

Ryan D. Pardy, Maaran M. Rajah, Stephanie A. Condotta, Nathan G. Taylor, Selena M. Sagan, Martin J. Richer

PLOS Pathogens: published February 23, 2017 | https://doi.org/10.1371/journal.ppat.1006184

Ex vivo activation of CD4⁺ T-cells from donors on suppressive ART can lead to sustained production of infectious HIV-1 from a subset of infected cells

John K. Bui, Elias K. Halvas, Elizabeth Fyne, Michele D. Sobolewski, Dianna Koontz, Wei Shao, Brian Luke, Feiyu F. Hong, Mary F. Kearney, John W. Mellors

PLOS Pathogens: published February 22, 2017 | https://doi.org/10.1371/journal.ppat.1006230

Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design

Adriana Irimia, Andreia M. Serra, Anita Sarkar, Ronald Jacak, Oleksandr Kalyuzhniy, Devin Sok, Karen L. Saye-Francisco, Torben Schiffner, Ryan Tingle, Michael Kubitz, Yumiko Adachi, Robyn L. Stanfield, Marc C. Deller, Dennis R. Burton, William R. Schief, Ian A. Wilson

PLOS Pathogens: published February 22, 2017 | https://doi.org/10.1371/journal.ppat.1006212

ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria

Milica Milivojevic, Anne-Sophie Dangeard, Christoph Alexander Kasper, Therese Tschon, Mario Emmenlauer, Claudine Pique, Pamela Schnupf, Julie Guignot, Cécile Arrieumerlou

PLOS Pathogens: published February 21, 2017 | https://doi.org/10.1371/journal.ppat.1006224

The thermodynamics of Pr55^Gag-RNA interaction regulate the assembly of HIV

Hanumant S. Tanwar, Keith K. Khoo, Megan Garvey, Lynne Waddington, Andrew Leis, Marcel Hijnen, Tony Velkov, Geoff J. Dumsday, William J. McKinstry, Johnson Mak

PLOS Pathogens: published February 21, 2017 | https://doi.org/10.1371/journal.ppat.1006221

A high-throughput genetic screen identifies previously uncharacterized Borrelia burgdorferi genes important for resistance against reactive oxygen and nitrogen species

Meghan E. Ramsey, Jenny A. Hyde, Diana N. Medina-Perez, Tao Lin, Lihui Gao, Maureen E. Lundt, Xin Li, Steven J. Norris, Jon T. Skare, Linden T. Hu

PLOS Pathogens: published February 17, 2017 | https://doi.org/10.1371/journal.ppat.1006225

SUMO modification of a heterochromatin histone demethylase JMJD2A enables viral gene transactivation and viral replication

Wan-Shan Yang, Mel Campbell, Pei-Ching Chang

PLOS Pathogens: published February 17, 2017 | https://doi.org/10.1371/journal.ppat.1006216

A calmodulin-like protein suppresses RNA silencing and promotes geminivirus infection by degrading SGS3 via the autophagy pathway in Nicotiana benthamiana

Fangfang Li, Nan Zhao, Zhenghe Li, Xiongbiao Xu, Yaqin Wang, Xiuling Yang, Shu-Sheng Liu, Aiming Wang, Xueping Zhou

PLOS Pathogens: published February 17, 2017 | https://doi.org/10.1371/journal.ppat.1006213

A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis

Leslie Goo, Laura A. VanBlargan, Kimberly A. Dowd, Michael S. Diamond, Theodore C. Pierson

PLOS Pathogens: published February 16, 2017 | https://doi.org/10.1371/journal.ppat.1006178

Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells

Jason A. Neidleman, Joseph C. Chen, Nargis Kohgadai, Janis A. Müller, Anders Laustsen, Karthiga Thavachelvam, Karen S. Jang, Christina M. Stürzel, Jennifer J. Jones, Christina Ochsenbauer, Avantika Chitre, Ma Somsouk, Maurice M. Garcia, James F. Smith, Ruth M. Greenblatt, Jan Münch, Martin R. Jakobsen, Linda C. Giudice, Warner C. Greene, Nadia R. Roan

PLOS Pathogens: published February 16, 2017 | https://doi.org/10.1371/journal.ppat.1006163

RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation

Jane A. C. Wilson, Natalie A. Prow, Wayne A. Schroder, Jonathan J. Ellis, Helen E. Cumming, Linden J. Gearing, Yee Suan Poo, Adam Taylor, Paul J. Hertzog, Francesca Di Giallonardo, Linda Hueston, Roger Le Grand, Bing Tang, Thuy T. Le, Joy Gardner, Suresh Mahalingam, Pierre Roques, Phillip I. Bird, Andreas Suhrbier

PLOS Pathogens: published February 16, 2017 | https://doi.org/10.1371/journal.ppat.1006155

Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy

Raja Ganesan, Nina Judith Hos, Saray Gutierrez, Julia Fischer, Joanna Magdalena Stepek, Evmorphia Daglidu, Martin Krönke, Nirmal Robinson

PLOS Pathogens: published February 13, 2017 | https://doi.org/10.1371/journal.ppat.1006227

Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion

Sumaira Z. Hasnain, Paul A. Dawson, Rohan Lourie, Peter Hutson, Hui Tong, Richard K. Grencis, Michael A. McGuckin, David J. Thornton

PLOS Pathogens: published February 13, 2017 | https://doi.org/10.1371/journal.ppat.1006218

Multi-layered control of Galectin-8 mediated autophagy during adenovirus cell entry through a conserved PPxY motif in the viral capsid

Charlotte Montespan, Shauna A. Marvin, Sisley Austin, Andrew M. Burrage, Benoit Roger, Fabienne Rayne, Muriel Faure, Edward M. Campell, Carola Schneider, Rudolph Reimer, Kay Grünewald, Christopher M. Wiethoff, Harald Wodrich

PLOS Pathogens: published February 13, 2017 | https://doi.org/10.1371/journal.ppat.1006217

Role of Arf GTPases in fungal morphogenesis and virulence

Hayet Labbaoui, Stéphanie Bogliolo, Vikram Ghugtyal, Norma V. Solis, Scott G. Filler, Robert A. Arkowitz, Martine Bassilana

PLOS Pathogens: published February 13, 2017 | https://doi.org/10.1371/journal.ppat.1006205

CD8⁺ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production

Fernanda O. Novais, Augusto M. Carvalho, Megan L. Clark, Lucas P. Carvalho, Daniel P. Beiting, Igor E. Brodsky, Edgar M. Carvalho, Phillip Scott

PLOS Pathogens: published February 13, 2017 | https://doi.org/10.1371/journal.ppat.1006196

Functional diversity of secreted cestode Kunitz proteins: Inhibition of serine peptidases and blockade of cation channels

Martín Fló, Mariana Margenat, Leonardo Pellizza, Martín Graña, Rosario Durán, Adriana Báez, Emilio Salceda, Enrique Soto, Beatriz Alvarez, Cecilia Fernández

PLOS Pathogens: published February 13, 2017 | https://doi.org/10.1371/journal.ppat.1006169

Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assay

Mart Toots, Mart Ustav Jr., Andres Männik, Karl Mumm, Kaido Tämm, Tarmo Tamm, Ene Ustav, Mart Ustav

PLOS Pathogens: published February 9, 2017 | https://doi.org/10.1371/journal.ppat.1006168

Comparative analysis estimates the relative frequencies of co-divergence and cross-species transmission within viral families

Jemma L. Geoghegan, Sebastián Duchêne, Edward C. Holmes

PLOS Pathogens: published February 8, 2017 | https://doi.org/10.1371/journal.ppat.1006215

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens

Sanduni V. Hapuarachchi, Simon A. Cobbold, Sarah H. Shafik, Adelaide S. M. Dennis, Malcolm J. McConville, Rowena E. Martin, Kiaran Kirk, Adele M. Lehane

PLOS Pathogens: published February 8, 2017 | https://doi.org/10.1371/journal.ppat.1006180

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André Golldack, Björn Henke, Bärbel Bergmann, Marie Wiechert, Holger Erler, Alexandra Blancke Soares, Tobias Spielmann, Eric Beitz

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The effective rate of influenza reassortment is limited during human infection

Ashley Sobel Leonard, Micah T. McClain, Gavin J. D. Smith, David E. Wentworth, Rebecca A. Halpin, Xudong Lin, Amy Ransier, Timothy B. Stockwell, Suman R. Das, Anthony S. Gilbert, Rob Lambkin-Williams, Geoffrey S. Ginsburg, Christopher W. Woods, Katia Koelle, Christopher J. R. Illingworth

PLOS Pathogens: published February 7, 2017 | https://doi.org/10.1371/journal.ppat.1006203

Picornavirus RNA is protected from cleavage by ribonuclease during virion uncoating and transfer across cellular and model membranes

Elisabetta Groppelli, Hazel C. Levy, Eileen Sun, Mike Strauss, Clare Nicol, Sarah Gold, Xiaowei Zhuang, Tobias J. Tuthill, James M. Hogle, David J. Rowlands

PLOS Pathogens: published February 6, 2017 | https://doi.org/10.1371/journal.ppat.1006197

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication

Eveline Kindler, Cristina Gil-Cruz, Julia Spanier, Yize Li, Jochen Wilhelm, Huib H. Rabouw, Roland Züst, Mihyun Hwang, Philip V’kovski, Hanspeter Stalder, Sabrina Marti, Matthias Habjan, Luisa Cervantes-Barragan, Ruth Elliot, Nadja Karl, Christina Gaughan, Frank J. M. van Kuppeveld, Robert H. Silverman, Markus Keller, Burkhard Ludewig, Cornelia C. Bergmann, John Ziebuhr, Susan R. Weiss, Ulrich Kalinke, Volker Thiel

PLOS Pathogens: published February 3, 2017 | https://doi.org/10.1371/journal.ppat.1006195

Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury

Martina Bielaszewska, Christian Rüter, Andreas Bauwens, Lilo Greune, Kevin-André Jarosch, Daniel Steil, Wenlan Zhang, Xiaohua He, Roland Lloubes, Angelika Fruth, Kwang Sik Kim, M. Alexander Schmidt, Ulrich Dobrindt, Alexander Mellmann, Helge Karch

PLOS Pathogens: published February 3, 2017 | https://doi.org/10.1371/journal.ppat.1006159

Identification of cyst nematode B-type CLE peptides and modulation of the vascular stem cell pathway for feeding cell formation

Xiaoli Guo, Jianying Wang, Michael Gardner, Hiroo Fukuda, Yuki Kondo, J. Peter Etchells, Xiaohong Wang, Melissa Goellner Mitchum

PLOS Pathogens: published February 3, 2017 | https://doi.org/10.1371/journal.ppat.1006142

Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα

Yani Hu, Kaitlin O’Boyle, Jim Auer, Sagar Raju, Fuping You, Penghua Wang, Erol Fikrig, Richard E. Sutton

PLOS Pathogens: published February 2, 2017 | https://doi.org/10.1371/journal.ppat.1006187

Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells

James R. Bowen, Kendra M. Quicke, Mohan S. Maddur, Justin T. O’Neal, Circe E. McDonald, Nadia B. Fedorova, Vinita Puri, Reed S. Shabman, Bali Pulendran, Mehul S. Suthar

PLOS Pathogens: published February 2, 2017 | https://doi.org/10.1371/journal.ppat.1006164

Toxin Mediates Sepsis Caused by Methicillin-Resistant Staphylococcus epidermidis

Li Qin, Fei Da, Emilie L. Fisher, Daniel C. S. Tan, Thuan H. Nguyen, Chih-Lung Fu, Vee Y. Tan, Joshua W. McCausland, Daniel E. Sturdevant, Hwang-Soo Joo, Shu Y. Queck, Gordon Y. C. Cheung, Michael Otto

PLOS Pathogens: published February 2, 2017 | https://doi.org/10.1371/journal.ppat.1006153

A positive-strand RNA virus uses alternative protein-protein interactions within a viral protease/cofactor complex to switch between RNA replication and virion morphogenesis

Danilo Dubrau, M. Alejandra Tortorici, Félix A. Rey, Norbert Tautz

PLOS Pathogens: published February 2, 2017 | https://doi.org/10.1371/journal.ppat.1006134

Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance

Mohamed S. Abdel-Hakeem, Maude Boisvert, Julie Bruneau, Hugo Soudeyns, Naglaa H. Shoukry

PLOS Pathogens: published February 1, 2017 | https://doi.org/10.1371/journal.ppat.1006191

The morphogenesis-related NDR kinase pathway of Colletotrichum orbiculare is required for translating plant surface signals into infection-related morphogenesis and pathogenesis

Sayo Kodama, Junya Ishizuka, Ito Miyashita, Takaaki Ishii, Takumi Nishiuchi, Hideto Miyoshi, Yasuyuki Kubo

PLOS Pathogens: published February 1, 2017 | https://doi.org/10.1371/journal.ppat.1006189