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Table of Contents

February 2017

HIV-infected SupT1 T cells forming characteristic multinucleated syncytia following virus-induced cell-cell fusion events in cell culture. Photo taken with an iPhone 4 and a light microscope. Compton et al.

Image Credit: Alex Compton

Opinion

New Paradigms to Help Solve the Global Aquaculture Disease Crisis

Grant D. Stentiford, Kallaya Sritunyalucksana, Timothy W. Flegel, Bryony A. P. Williams, Boonsirm Withyachumnarnkul, Orn Itsathitphaisarn, David Bass

Review

Resolving host–pathogen interactions by dual RNA-seq

Alexander J. Westermann, Lars Barquist, Jörg Vogel

Research Articles

Release of HIV-1 sequestered in the vesicles of oral and genital mucosal epithelial cells by epithelial-lymphocyte interaction

Aizezi Yasen, Rossana Herrera, Kristina Rosbe, Kathy Lien, Sharof M. Tugizov

Nematode neuropeptides as transgenic nematicides

Neil D. Warnock, Leonie Wilson, Cheryl Patten, Colin C. Fleming, Aaron G. Maule, Johnathan J. Dalzell

Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells

Yanlin Fan, Yusong R. Guo, Wang Yuan, Ying Zhou, Matthew V. Holt, Tao Wang, Borries Demeler, Nicolas L. Young, Weiwei Zhong, Yizhi J. Tao

The transcriptome of HIV-1 infected intestinal CD4+ T cells exposed to enteric bacteria

Alyson C. Yoder, Kejun Guo, Stephanie M. Dillon, Tzu Phang, Eric J. Lee, Michael S. Harper, Karen Helm, John C. Kappes, Christina Ochsenbauer, Martin D. McCarter, Cara C. Wilson, Mario L. Santiago

OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans

Beatriz Sierra, Petr Triska, Pedro Soares, Gissel Garcia, Ana B. Perez, Eglys Aguirre, Marisa Oliveira, Bruno Cavadas, Béatrice Regnault, Mayling Alvarez, Didye Ruiz, David C. Samuels, Anavaj Sakuntabhai, Luisa Pereira, Maria G. Guzman

Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction

Ekaterina Maidji, Ma Somsouk, Jose M. Rivera, Peter W. Hunt, Cheryl A. Stoddart

Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation

Vanessa C. McFadden, Rasha E. Shalaby, Saira Iram, Claudia E. Oropeza, Jennifer A. Landolfi, Alexander V. Lyubimov, Mark Maienschein-Cline, Stefan J. Green, Klaus H. Kaestner, Alan McLachlan

Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1

Ramy El-Diwany, Valerie J. Cohen, Madeleine C. Mankowski, Lisa N. Wasilewski, Jillian K. Brady, Anna E. Snider, William O. Osburn, Ben Murrell, Stuart C. Ray, Justin R. Bailey

Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo

Nirjal Bhattarai, James H. McLinden, Jinhua Xiang, M. Meleah Mathahs, Warren N. Schmidt, Thomas M. Kaufman, Jack T. Stapleton

Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial

David Easterhoff, M. Anthony Moody, Daniela Fera, Hao Cheng, Margaret Ackerman, Kevin Wiehe, Kevin O. Saunders, Justin Pollara, Nathan Vandergrift, Rob Parks, Jerome Kim, Nelson L. Michael, Robert J. O’Connell, Jean-Louis Excler, Merlin L. Robb, Sandhya Vasan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Sorachai Nitayaphan, Faruk Sinangil, James Tartaglia, Sanjay Phogat, Thomas B. Kepler, S. Munir Alam, Hua-Xin Liao, Guido Ferrari, Michael S. Seaman, David C. Montefiori, Georgia D. Tomaras, Stephen C. Harrison, Barton F. Haynes

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function

Christine Burkard, Simon G. Lillico, Elizabeth Reid, Ben Jackson, Alan J. Mileham, Tahar Ait-Ali, C. Bruce A. Whitelaw, Alan L. Archibald

A mouse model of paralytic myelitis caused by enterovirus D68

Alison M. Hixon, Guixia Yu, J. Smith Leser, Shigeo Yagi, Penny Clarke, Charles Y. Chiu, Kenneth L. Tyler

Analysis of the T Cell Response to Zika Virus and Identification of a Novel CD8+ T Cell Epitope in Immunocompetent Mice

Ryan D. Pardy, Maaran M. Rajah, Stephanie A. Condotta, Nathan G. Taylor, Selena M. Sagan, Martin J. Richer

Ex vivo activation of CD4+ T-cells from donors on suppressive ART can lead to sustained production of infectious HIV-1 from a subset of infected cells

John K. Bui, Elias K. Halvas, Elizabeth Fyne, Michele D. Sobolewski, Dianna Koontz, Wei Shao, Brian Luke, Feiyu F. Hong, Mary F. Kearney, John W. Mellors

Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design

Adriana Irimia, Andreia M. Serra, Anita Sarkar, Ronald Jacak, Oleksandr Kalyuzhniy, Devin Sok, Karen L. Saye-Francisco, Torben Schiffner, Ryan Tingle, Michael Kubitz, Yumiko Adachi, Robyn L. Stanfield, Marc C. Deller, Dennis R. Burton, William R. Schief, Ian A. Wilson

ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria

Milica Milivojevic, Anne-Sophie Dangeard, Christoph Alexander Kasper, Therese Tschon, Mario Emmenlauer, Claudine Pique, Pamela Schnupf, Julie Guignot, Cécile Arrieumerlou

The thermodynamics of Pr55Gag-RNA interaction regulate the assembly of HIV

Hanumant S. Tanwar, Keith K. Khoo, Megan Garvey, Lynne Waddington, Andrew Leis, Marcel Hijnen, Tony Velkov, Geoff J. Dumsday, William J. McKinstry, Johnson Mak

A high-throughput genetic screen identifies previously uncharacterized Borrelia burgdorferi genes important for resistance against reactive oxygen and nitrogen species

Meghan E. Ramsey, Jenny A. Hyde, Diana N. Medina-Perez, Tao Lin, Lihui Gao, Maureen E. Lundt, Xin Li, Steven J. Norris, Jon T. Skare, Linden T. Hu

A calmodulin-like protein suppresses RNA silencing and promotes geminivirus infection by degrading SGS3 via the autophagy pathway in Nicotiana benthamiana

Fangfang Li, Nan Zhao, Zhenghe Li, Xiongbiao Xu, Yaqin Wang, Xiuling Yang, Shu-Sheng Liu, Aiming Wang, Xueping Zhou

A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis

Leslie Goo, Laura A. VanBlargan, Kimberly A. Dowd, Michael S. Diamond, Theodore C. Pierson

Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells

Jason A. Neidleman, Joseph C. Chen, Nargis Kohgadai, Janis A. Müller, Anders Laustsen, Karthiga Thavachelvam, Karen S. Jang, Christina M. Stürzel, Jennifer J. Jones, Christina Ochsenbauer, Avantika Chitre, Ma Somsouk, Maurice M. Garcia, James F. Smith, Ruth M. Greenblatt, Jan Münch, Martin R. Jakobsen, Linda C. Giudice, Warner C. Greene, Nadia R. Roan

RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation

Jane A. C. Wilson, Natalie A. Prow, Wayne A. Schroder, Jonathan J. Ellis, Helen E. Cumming, Linden J. Gearing, Yee Suan Poo, Adam Taylor, Paul J. Hertzog, Francesca Di Giallonardo, Linda Hueston, Roger Le Grand, Bing Tang, Thuy T. Le, Joy Gardner, Suresh Mahalingam, Pierre Roques, Phillip I. Bird, Andreas Suhrbier

Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy

Raja Ganesan, Nina Judith Hos, Saray Gutierrez, Julia Fischer, Joanna Magdalena Stepek, Evmorphia Daglidu, Martin Krönke, Nirmal Robinson

Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion

Sumaira Z. Hasnain, Paul A. Dawson, Rohan Lourie, Peter Hutson, Hui Tong, Richard K. Grencis, Michael A. McGuckin, David J. Thornton

Multi-layered control of Galectin-8 mediated autophagy during adenovirus cell entry through a conserved PPxY motif in the viral capsid

Charlotte Montespan, Shauna A. Marvin, Sisley Austin, Andrew M. Burrage, Benoit Roger, Fabienne Rayne, Muriel Faure, Edward M. Campell, Carola Schneider, Rudolph Reimer, Kay Grünewald, Christopher M. Wiethoff, Harald Wodrich

Role of Arf GTPases in fungal morphogenesis and virulence

Hayet Labbaoui, Stéphanie Bogliolo, Vikram Ghugtyal, Norma V. Solis, Scott G. Filler, Robert A. Arkowitz, Martine Bassilana

CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production

Fernanda O. Novais, Augusto M. Carvalho, Megan L. Clark, Lucas P. Carvalho, Daniel P. Beiting, Igor E. Brodsky, Edgar M. Carvalho, Phillip Scott

Functional diversity of secreted cestode Kunitz proteins: Inhibition of serine peptidases and blockade of cation channels

Martín Fló, Mariana Margenat, Leonardo Pellizza, Martín Graña, Rosario Durán, Adriana Báez, Emilio Salceda, Enrique Soto, Beatriz Alvarez, Cecilia Fernández

Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assay

Mart Toots, Mart Ustav Jr., Andres Männik, Karl Mumm, Kaido Tämm, Tarmo Tamm, Ene Ustav, Mart Ustav

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens

Sanduni V. Hapuarachchi, Simon A. Cobbold, Sarah H. Shafik, Adelaide S. M. Dennis, Malcolm J. McConville, Rowena E. Martin, Kiaran Kirk, Adele M. Lehane

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