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Revising Your Manuscript

Submission Instructions

If you are submitting a revised manuscript, upload your revised submission to the submission system and include the following items:

  • Response to reviewers: Address the specific points made by each reviewer. Include your responses to all the reviewers’ and editors’ comments and list the changes you have made to the manuscript. Remember, if you choose to publish the peer review history of your manuscript, your response to reviewers will appear online alongside the final article. Upload this document as a “Response to reviewers” file.

Reviewers will be able to see your cover letter and response to reviewers. Please send anything confidential directly to the journal office.
  • Revised manuscript (marked-up copy): Include a marked-up copy of your manuscript file showing the changes you have made since the original submission. The best way to show these changes is the “Track Changes” option in Microsoft Word. Upload this as a "Revised Article with Changes Highlighted” file.

  • Revised manuscript (clean copy): Upload a clean copy of your revised manuscript that does not show your changes. Upload this as your “Manuscript” file.

Figures and supporting information files from your original submission will automatically transfer to your revised submission unless you choose to update and replace them. 

Request an Extension

Our standard resubmission deadlines are 60 days for a Major Revision decision and 30 days for a Minor Revision decision. We are always happy to grant short extensions for resubmissions. Please email with any questions.

Updating a preprint

If you chose to post your manuscript on bioRxiv during PLOS initial submission, you may update or revise your preprint directly on bioRxiv at any time. Consult the bioRxiv submit page for specific instructions.