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July 2018

This confocal image captured in the spleen at day 3 post-infection shows the anatomical confinement of lymphocytic choriomeningitis virus clone 13 (green) to the splenic marginal zone, which is promoted in part by the type I interferon-inducible antiviral protein, BST-2 (red). McGavern et al.

Image Credit: McGavern et al.

Pearls

Beyond the myths: Novel findings for old paradigms in the history of the smallpox vaccine

José Esparza, Andreas Nitsche, Clarissa R. Damaso

Illuminating pathogen–host intimacy through optogenetics

Ruben Dario Arroyo-Olarte, Laura Thurow, Vera Kozjak-Pavlovic, Nishith Gupta

GPCR-bigrams: Enigmatic signaling components in oomycetes

Johan van den Hoogen, Francine Govers

Research Articles

Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence

Ning-Ning Liu, Priya Uppuluri, Achille Broggi, Angelique Besold, Kicki Ryman, Hiroto Kambara, Norma Solis, Viola Lorenz, Wanjun Qi, Maikel Acosta-Zaldívar, S. Noushin Emami, Bin Bao, Dingding An, Francisco A. Bonilla, Martha Sola-Visner, Scott G. Filler, Hongbo R. Luo, Ylva Engström, Per Olof Ljungdahl, Valeria C. Culotta, Ivan Zanoni, Jose L. Lopez-Ribot, Julia R. Köhler

Killing with proficiency: Integrated post-translational regulation of an offensive Type VI secretion system

Adam Ostrowski, Francesca R. Cianfanelli, Michael Porter, Giuseppina Mariano, Julien Peltier, Jun Jie Wong, Jason R. Swedlow, Matthias Trost, Sarah J. Coulthurst

Epstein-Barr virus activates F-box protein FBXO2 to limit viral infectivity by targeting glycoprotein B for degradation

Hao-Jiong Zhang, Jinxiu Tian, Xue-Kang Qi, Tong Xiang, Gui-Ping He, Hua Zhang, Xibao Yu, Xiao Zhang, Bingchun Zhao, Qi-Sheng Feng, Ming-Yuan Chen, Mu-Sheng Zeng, Yi-Xin Zeng, Lin Feng

Invasion of midgut epithelial cells by a persistently transmitted virus is mediated by sugar transporter 6 in its insect vector

Faliang Qin, Wenwen Liu, Nan Wu, Lu Zhang, Zhongkai Zhang, Xueping Zhou, Xifeng Wang

A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection

Jillian A. Bristol, Reza Djavadian, Emily R. Albright, Carrie B. Coleman, Makoto Ohashi, Mitchell Hayes, James C. Romero-Masters, Elizabeth A. Barlow, Paul J. Farrell, Rosemary Rochford, Robert F. Kalejta, Eric C. Johannsen, Shannon C. Kenney

Evolution of HIV-1 within untreated individuals and at the population scale in Uganda

Jayna Raghwani, Andrew D. Redd, Andrew F. Longosz, Chieh-Hsi Wu, David Serwadda, Craig Martens, Joseph Kagaayi, Nelson Sewankambo, Stephen F. Porcella, Mary K. Grabowski, Thomas C. Quinn, Michael A. Eller, Leigh Anne Eller, Fred Wabwire-Mangen, Merlin L. Robb, Christophe Fraser, Katrina A. Lythgoe

Chronic schistosomiasis suppresses HIV-specific responses to DNA-MVA and MVA-gp140 Env vaccine regimens despite antihelminthic treatment and increases helminth-associated pathology in a mouse model

Godfrey A. Dzhivhuho, Samantha A. Rehrl, Hlumani Ndlovu, William G. C. Horsnell, Frank Brombacher, Anna-Lise Williamson, Gerald K. Chege

Identification of virus-encoded microRNAs in divergent Papillomaviruses

Rachel Chirayil, Rodney P. Kincaid, Christine Dahlke, Chad V. Kuny, Nicole Dälken, Michael Spohn, Becki Lawson, Adam Grundhoff, Christopher S. Sullivan

Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus

Jinliang Wang, Zilong Wang, Renqiang Liu, Lei Shuai, Xinxin Wang, Jie Luo, Chong Wang, Weiye Chen, Xijun Wang, Jinying Ge, Xijun He, Zhiyuan Wen, Zhigao Bu

Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons

Margaret A. MacGibeny, Orkide O. Koyuncu, Christoph Wirblich, Matthias J. Schnell, Lynn W. Enquist

BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection

Shuzo Urata, Elizabeth Kenyon, Debasis Nayak, Beatrice Cubitt, Yohei Kurosaki, Jiro Yasuda, Juan C. de la Torre, Dorian B. McGavern

Antibody to Poly-N-acetyl glucosamine provides protection against intracellular pathogens: Mechanism of action and validation in horse foals challenged with Rhodococcus equi

Colette Cywes-Bentley, Joana N. Rocha, Angela I. Bordin, Mariana Vinacur, Safia Rehman, Tanweer S. Zaidi, Mark Meyer, Sarah Anthony, McKenzie Lambert, Daniel R. Vlock, Steeve Giguère, Noah D. Cohen, Gerald B. Pier

Population genomics shows no distinction between pathogenic Candida krusei and environmental Pichia kudriavzevii: One species, four names

Alexander P. Douglass, Benjamin Offei, Stephanie Braun-Galleani, Aisling Y. Coughlan, Alexandre A. R. Martos, Raúl A. Ortiz-Merino, Kevin P. Byrne, Kenneth H. Wolfe

Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB

Janina Bruening, Lisa Lasswitz, Pia Banse, Sina Kahl, Carine Marinach, Florian W. Vondran, Lars Kaderali, Olivier Silvie, Thomas Pietschmann, Felix Meissner, Gisa Gerold

Mitochondrial DNA is critical for longevity and metabolism of transmission stage Trypanosoma brucei

Caroline E. Dewar, Paula MacGregor, Sinclair Cooper, Matthew K. Gould, Keith R. Matthews, Nicholas J. Savill, Achim Schnaufer

Inhibition of Japanese encephalitis virus infection by the host zinc-finger antiviral protein

Hsin-Ping Chiu, Han Chiu, Chao-Fu Yang, Yi-Ling Lee, Feng-Lan Chiu, Hung-Chih Kuo, Ren-Jye Lin, Yi-Ling Lin

Neutrophils use superoxide to control bacterial infection at a distance

Quang Tien Phan, Tamara Sipka, Catherine Gonzalez, Jean-Pierre Levraud, Georges Lutfalla, Mai Nguyen-Chi

Heterogeneity in pneumolysin expression governs the fate of Streptococcus pneumoniae during blood-brain barrier trafficking

Manalee Vishnu Surve, Smita Bhutda, Akshay Datey, Anjali Anil, Shalini Rawat, Athira Pushpakaran, Dipty Singh, Kwang Sik Kim, Dipshikha Chakravortty, Anirban Banerjee

Epidemiological significance of dengue virus genetic variation in mosquito infection dynamics

Albin Fontaine, Sebastian Lequime, Isabelle Moltini-Conclois, Davy Jiolle, Isabelle Leparc-Goffart, Robert Charles Reiner Jr, Louis Lambrechts

Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV

Vickie A. Marshall, Nazzarena Labo, Xing-Pei Hao, Benjamin Holdridge, Marshall Thompson, Wendell Miley, Catherine Brands, Vicky Coalter, Rebecca Kiser, Miriam Anver, Yelena Golubeva, Andrew Warner, Elaine S. Jaffe, Michael Piatak Jr., Scott W. Wong, Claes Ohlen, Rhonda MacAllister, Jeremy Smedley, Claire Deleage, Gregory Q. Del Prete, Jeffrey D. Lifson, Jacob D. Estes, Denise Whitby

DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection

María Eugenia Loureiro, Andre Luiz Zorzetto-Fernandes, Sheli Radoshitzky, Xiaoli Chi, Simone Dallari, Nuha Marooki, Psylvia Lèger, Sabrina Foscaldi, Vince Harjono, Sonia Sharma, Brian M. Zid, Nora López, Juan Carlos de la Torre, Sina Bavari, Elina Zúñiga

KSHV-induced ligand mediated activation of PDGF receptor-alpha drives Kaposi's sarcomagenesis

Lucas E. Cavallin, Qi Ma, Julian Naipauer, Sachin Gupta, Mani Kurian, Paola Locatelli, Paolo Romanelli, Mehrdad Nadji, Pascal J. Goldschmidt-Clermont, Enrique A. Mesri

PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves

Chyntia Carolina Díaz Acosta, André Alves Dias, Thabatta Leal Silveira Andrezo Rosa, Leonardo Ribeiro Batista-Silva, Patricia Sammarco Rosa, Thiago Gomes Toledo-Pinto, Fabrício da Mota Ramalho Costa, Flávio Alves Lara, Luciana Silva Rodrigues, Katherine Antunes Mattos, Euzenir Nunes Sarno, Patrícia Torres Bozza, Christophe Guilhot, Márcia de Berrêdo-Pinho, Maria Cristina Vidal Pessolani

Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV

Adam S. Dingens, Priyamvada Acharya, Hugh K. Haddox, Reda Rawi, Kai Xu, Gwo-Yu Chuang, Hui Wei, Baoshan Zhang, John R. Mascola, Bridget Carragher, Clinton S. Potter, Julie Overbaugh, Peter D. Kwong, Jesse D. Bloom

SliC is a surface-displayed lipoprotein that is required for the anti-lysozyme strategy during Neisseria gonorrhoeae infection

Ryszard A. Zielke, Adriana Le Van, Benjamin I. Baarda, Marco F. Herrera, Christopher J. Acosta, Ann E. Jerse, Aleksandra E. Sikora

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