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Table of Contents

August 2019

RSV infection (RSV fusion protein in red) induces clustering of the transmembrane cellular ATP1A1 protein (green, alpha-1 subunit of the Na+, K+-ATPase complex) on the apical surface of differentiated mucociliary human airway epithelial cells (nuclei in blue and F-actin in cyan). ATP1A1 initiates signaling that results in the macropinocytic uptake of RSV. The three-dimensional image was reconstructed from images of immunostained cells obtained by confocal microscopy (colors were modified for this illustration). Lingemann et al.

Image Credit: Matthias Lingemann (2019).

Opinion

Evolution of negative immune regulators

Steven A. Frank, Paul Schmid-Hempel

Pearls

Human bornavirus research: Back on track!

Dennis Rubbenstroth, Kore Schlottau, Martin Schwemmle, Jürgen Rissland, Martin Beer

Genetic transduction by phages and chromosomal islands: The new and noncanonical

Yin Ning Chiang, José R. Penadés, John Chen

Parasite-microbe-host interactions and cancer risk

Nolwenn M. Dheilly, Paul W. Ewald, Paul J. Brindley, Raina N. Fichorova, Frédéric Thomas

The fading boundaries between patient and environmental routes of triazole resistance selection in Aspergillus fumigatus

Jochem B. Buil, Rasmus K. Hare, Bas J. Zwaan, Maiken C. Arendrup, Willem J. G. Melchers, Paul E. Verweij

Selective pressure: Rise of the nonencapsulated pneumococcus

Jessica L. Bradshaw, Larry S. McDaniel

Review

Research Articles

Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques

Meghan E. Breitbach, Christina M. Newman, Dawn M. Dudley, Laurel M. Stewart, Matthew T. Aliota, Michelle R. Koenig, Phoenix M. Shepherd, Keisuke Yamamoto, Chelsea M. Crooks, Ginger Young, Matthew R. Semler, Andrea M. Weiler, Gabrielle L. Barry, Holly Heimsath, Emma L. Mohr, Jens Eichkoff, Wendy Newton, Eric Peterson, Nancy Schultz-Darken, Sallie R. Permar, Hansi Dean, Saverio Capuano 3rd, Jorge E. Osorio, Thomas C. Friedrich, David H. O’Connor

The novel interaction between Neisseria gonorrhoeae TdfJ and human S100A7 allows gonococci to subvert host zinc restriction

Stavros Maurakis, Kayla Keller, C. Noel Maxwell, Kevin Pereira, Walter J. Chazin, Alison K. Criss, Cynthia Nau Cornelissen

HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response

Michael A. Joyce, Karyn M. Berry-Wynne, Theodore dos Santos, William R. Addison, Nicola McFarlane, Tom Hobman, D. Lorne Tyrrell

Cell-length heterogeneity: a population-level solution to growth/virulence trade-offs in the plant pathogen Dickeya dadantii

Zhouqi Cui, Ching-Hong Yang, Roshni R. Kharadi, Xiaochen Yuan, George W. Sundin, Lindsay R. Triplett, Jie Wang, Quan Zeng

The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells

Matthias Lingemann, Thomas McCarty, Xueqiao Liu, Ursula J. Buchholz, Sonja Surman, Scott E. Martin, Peter L. Collins, Shirin Munir

Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites

Vladimira Horova, Heyrhyoung Lyoo, Bartosz Różycki, Dominika Chalupska, Miroslav Smola, Jana Humpolickova, Jeroen R. P. M. Strating, Frank J. M. van Kuppeveld, Evzen Boura, Martin Klima

The NDV-3A vaccine protects mice from multidrug resistant Candida auris infection

Shakti Singh, Priya Uppuluri, Zeinab Mamouei, Abdullah Alqarihi, Hana Elhassan, Samuel French, Shawn R. Lockhart, Tom Chiller, John E. Edwards Jr., Ashraf S. Ibrahim

NS2B/NS3 mutations enhance the infectivity of genotype I Japanese encephalitis virus in amplifying hosts

Yi-Chin Fan, Jian-Jong Liang, Jo-Mei Chen, Jen-Wei Lin, Yi-Ying Chen, Kuan-Hsuan Su, Chang-Chi Lin, Wu-Chun Tu, Ming-Tang Chiou, Shan-Chia Ou, Gwong-Jen J. Chang, Yi-Ling Lin, Shyan-Song Chiou

Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription

Victoria J. Madigan, Julianne A. Yuziuk, Anna M. Chiarella, Tyne O. Tyson, Rita M. Meganck, Zachary C. Elmore, Longping V. Tse, Nathaniel A. Hathaway, Aravind Asokan

Identification of murine gammaherpesvirus 68 miRNA-mRNA hybrids reveals miRNA target conservation among gammaherpesviruses including host translation and protein modification machinery

Whitney L. Bullard, Mehmet Kara, Lauren A. Gay, Sunantha Sethuraman, Yiping Wang, Shreya Nirmalan, Alim Esemenli, April Feswick, Brett A. Hoffman, Rolf Renne, Scott A. Tibbetts

CD8 T cells targeting adapted epitopes in chronic HIV infection promote dendritic cell maturation and CD4 T cell trans-infection

Kai Qin, Sushma Boppana, Victor Y. Du, Jonathan M. Carlson, Ling Yue, Dario A. Dilernia, Eric Hunter, Robbie B. Mailliard, Simon A. Mallal, Anju Bansal, Paul A. Goepfert

Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization

Alyson R. Warr, Troy P. Hubbard, Diana Munera, Carlos J. Blondel, Pia Abel zur Wiesch, Sören Abel, Xiaoxue Wang, Brigid M. Davis, Matthew K. Waldor

Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex

Gang Xu, Zhangchuan Xia, Feiyan Deng, Lin Liu, Qiming Wang, Yi Yu, Fubing Wang, Chengliang Zhu, Weiyong Liu, Zhikui Cheng, Ying Zhu, Li Zhou, Yi Zhang, Mengji Lu, Shi Liu

Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation

K. Kai McKinstry, Fahmida Alam, Valeria Flores-Malavet, Mate Z. Nagy, Stewart Sell, Andrea M. Cooper, Susan L. Swain, Tara M. Strutt

Fas-associated factor 1 mediates NADPH oxidase-induced reactive oxygen species production and proinflammatory responses in macrophages against Listeria infection

Tae-Hwan Kim, Hyun-Cheol Lee, Jae-Hoon Kim, C. Y. Hewawaduge, Kiramage Chathuranga, W. A. Gayan Chathuranga, Pathum Ekanayaka, H. M. S. M. Wijerathne, Chul-Joong Kim, Eunhee Kim, Jong-Soo Lee

Dysregulation of M segment gene expression contributes to influenza A virus host restriction

Brenda M. Calderon, Shamika Danzy, Gabrielle K. Delima, Nathan T. Jacobs, Ketaki Ganti, Megan R. Hockman, Graeme L. Conn, Anice C. Lowen, John Steel

STING is required for host defense against neuropathological West Nile virus infection

Kathryn McGuckin Wuertz, Piper M. Treuting, Emily A. Hemann, Katharina Esser-Nobis, Annelise G. Snyder, Jessica B. Graham, Brian P. Daniels, Courtney Wilkins, Jessica M. Snyder, Kathleen M. Voss, Andrew Oberst, Jennifer Lund, Michael Gale Jr.

Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations

Judith Grau-Expósito, Laura Luque-Ballesteros, Jordi Navarro, Adrian Curran, Joaquin Burgos, Esteban Ribera, Ariadna Torrella, Bibiana Planas, Rosa Badía, Mario Martin-Castillo, Jesús Fernández-Sojo, Meritxell Genescà, Vicenç Falcó, Maria J. Buzon

Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis

Natália Ketelut-Carneiro, Camila Oliveira Silva Souza, Luciana Benevides, Luiz Gustavo Gardinassi, Maria Cláudia Silva, Lucas Alves Tavares, Dario Simões Zamboni, João Santana Silva

The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors

Pan Cao, Wei-Wei Luo, Chen Li, Zhen Tong, Zhou-Qin Zheng, Lu Zhou, Yong Xiong, Shu Li

Dietary zinc and the control of Streptococcus pneumoniae infection

Bart A. Eijkelkamp, Jacqueline R. Morey, Stephanie L. Neville, Aimee Tan, Victoria G. Pederick, Nerida Cole, Prashina P. Singh, Cheryl-Lynn Y. Ong, Raquel Gonzalez de Vega, David Clases, Bliss A. Cunningham, Catherine E. Hughes, Iain Comerford, Erin B. Brazel, Jonathan J. Whittall, Charles D. Plumptre, Shaun R. McColl, James C. Paton, Alastair G. McEwan, Philip A. Doble, Christopher A. McDevitt

A stealth adhesion factor contributes to Vibrio vulnificus pathogenicity: Flp pili play roles in host invasion, survival in the blood stream and resistance to complement activation

Tra-My Duong-Nu, Kwangjoon Jeong, Seol Hee Hong, Sao Puth, Soo Young Kim, Wenzhi Tan, Kwang Ho Lee, Shee Eun Lee, Joon Haeng Rhee

Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis

Daniel T. Claiborne, Eileen P. Scully, Christine D. Palmer, Jessica L. Prince, Gladys N. Macharia, Jakub Kopycinski, Clive M. Michelo, Howard W. Wiener, Rachel Parker, Krystelle Nganou-Makamdop, Daniel Douek, Marcus Altfeld, Jill Gilmour, Matt A. Price, Jianming Tang, William Kilembe, Susan A. Allen, Eric Hunter

Toxoplasma gondii activates a Syk-CARD9-NF-κB signaling axis and gasdermin D-independent release of IL-1β during infection of primary human monocytes

William J. Pandori, Tatiane S. Lima, Sharmila Mallya, Tiffany H. Kao, Lanny Gov, Melissa B. Lodoen

The Klebsiella pneumoniae citrate synthase gene, gltA, influences site specific fitness during infection

Jay Vornhagen, Yuang Sun, Paul Breen, Valerie Forsyth, Lili Zhao, Harry L. T. Mobley, Michael A. Bachman

Plasma membrane damage repair is mediated by an acid sphingomyelinase in Entamoeba histolytica

Fátima Ramírez-Montiel, Claudia Mendoza-Macías, Sairy Andrade-Guillén, Ángeles Rangel-Serrano, Itzel Páramo-Pérez, Paris E. Rivera-Cuéllar, B. Liliana España-Sánchez, Gabriel Luna-Bárcenas, Fernando Anaya-Velázquez, Bernardo Franco, Felipe Padilla-Vaca

A single phosphoacceptor residue in BGLF3 is essential for transcription of Epstein-Barr virus late genes

Jinlin Li, Ann Walsh, TuKiet T. Lam, Henri-Jacques Delecluse, Ayman El-Guindy

Dermal and muscle fibroblasts and skeletal myofibers survive chikungunya virus infection and harbor persistent RNA

Alissa R. Young, Marissa C. Locke, Lindsey E. Cook, Bradley E. Hiller, Rong Zhang, Matthew L. Hedberg, Kristen J. Monte, Deborah J. Veis, Michael S. Diamond, Deborah J. Lenschow

The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection

Sara Rodríguez-Mora, Flore De Wit, Javier García-Perez, Mercedes Bermejo, María Rosa López-Huertas, Elena Mateos, Pilar Martí, Susana Rocha, Lorena Vigón, Frauke Christ, Zeger Debyser, Juan Jesús Vílchez, Mayte Coiras, José Alcamí

A nanobody targeting the translocated intimin receptor inhibits the attachment of enterohemorrhagic E. coli to human colonic mucosa

David Ruano-Gallego, Daniel A. Yara, Lorenza Di Ianni, Gad Frankel, Stephanie Schüller, Luis Ángel Fernández

Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents

Sergei Perov, Ofir Lidor, Nir Salinas, Nimrod Golan, Einav Tayeb- Fligelman, Maya Deshmukh, Dieter Willbold, Meytal Landau