Introducing Short Reports—A new platform for swiftly communicating research findings

Julia Squarr

PLOS Pathogens: published October 16, 2023 | https://doi.org/10.1371/journal.ppat.1011734

Prevention of zoonotic spillover: From relying on response to reducing the risk at source

Authored by the members of the One Health High-Level Expert Panel (OHHLEP), Wanda Markotter, Thomas C. Mettenleiter, Wiku B. Adisasmito, Salama Almuhairi, Casey Barton Behravesh, Pépé Bilivogui, Salome A. Bukachi, Natalia Casas, Natalia Cediel Becerra, Dominique F. Charron, Abhishek Chaudhary, Janice R. Ciacci Zanella, Andrew A. Cunningham, Osman Dar, Nitish Debnath, Baptiste Dungu, Elmoubasher Farag, George F. Gao, David T. S. Hayman, Margaret Khaitsa, Marion P. G. Koopmans, Catherine Machalaba, John S. Mackenzie, Serge Morand, Vyacheslav Smolenskiy, Lei Zhou

PLOS Pathogens: published October 5, 2023 | https://doi.org/10.1371/journal.ppat.1011504

The intriguing phenomenon of cross-kingdom infections of plant and insect viruses to fungi: Can other animal viruses also cross-infect fungi?

Ida Bagus Andika, Xinran Cao, Hideki Kondo, Liying Sun

PLOS Pathogens: published October 26, 2023 | https://doi.org/10.1371/journal.ppat.1011726

Candida glabrata: A powerhouse of resistance

Seána Duggan, Jane Usher

PLOS Pathogens: published October 5, 2023 | https://doi.org/10.1371/journal.ppat.1011651

Protective mechanisms of nonneutralizing antiviral antibodies

Tawny L. Chandler, Agnes Yang, Claire E. Otero, Sallie R. Permar, Sarah L. Caddy

PLOS Pathogens: published October 5, 2023 | https://doi.org/10.1371/journal.ppat.1011670

Grapevine red blotch disease: A comprehensive Q&A guide

Björn Krenz, Marc Fuchs, Jeremy R. Thompson

PLOS Pathogens: published October 12, 2023 | https://doi.org/10.1371/journal.ppat.1011671

Tools and techniques to identify, study, and control Candida auris

James Carty, Anuradha Chowdhary, Douglas Bernstein, Shankar Thangamani

PLOS Pathogens: published October 19, 2023 | https://doi.org/10.1371/journal.ppat.1011698

Innate lymphoid cells—Underexplored guardians of immunity

Irina Tsymala, Karl Kuchler

PLOS Pathogens: published October 19, 2023 | https://doi.org/10.1371/journal.ppat.1011678

Know the enemy and know yourself: Addressing cryptic fungal pathogens of humans and beyond

Jacob L. Steenwyk, Antonis Rokas, Gustavo H. Goldman

PLOS Pathogens: published October 19, 2023 | https://doi.org/10.1371/journal.ppat.1011704

The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites

Megan Okada, Paul A. Sigala

PLOS Pathogens: published October 26, 2023 | https://doi.org/10.1371/journal.ppat.1011713

Prion propagation and cellular dysfunction in prion disease: Disconnecting the dots

Simote T. Foliaki, Cathryn L. Haigh

PLOS Pathogens: published October 26, 2023 | https://doi.org/10.1371/journal.ppat.1011714

Mechanistic insights into the interaction between the host gut microbiome and malaria

Rabindra K. Mandal, Nathan W. Schmidt

PLOS Pathogens: published October 12, 2023 | https://doi.org/10.1371/journal.ppat.1011665

Intestinal injury and the gut microbiota in patients with Plasmodium falciparum malaria

Natthida Sriboonvorakul, Kesinee Chotivanich, Udomsak Silachamroon, Weerapong Phumratanaprapin, John H. Adams, Arjen M. Dondorp, Stije J. Leopold

PLOS Pathogens: published October 19, 2023 | https://doi.org/10.1371/journal.ppat.1011661

Proximity-dependent mapping of the HCMV US28 interactome identifies RhoGEF signaling as a requirement for efficient viral reactivation

Samuel Medica, Lindsey B. Crawford, Michael Denton, Chan-Ki Min, Taylor A. Jones, Timothy Alexander, Christopher J. Parkins, Nicole L. Diggins, Gabriel J. Streblow, Adam T. Mayo, Craig N. Kreklywich, Patricia Smith, Sophia Jeng, Shannon McWeeney, Meaghan H. Hancock, Andrew Yurochko, Michael S. Cohen, Patrizia Caposio, Daniel N. Streblow

PLOS Pathogens: published October 2, 2023 | https://doi.org/10.1371/journal.ppat.1011682

Identification of IMC43, a novel IMC protein that collaborates with IMC32 to form an essential daughter bud assembly complex in Toxoplasma gondii

Rebecca R. Pasquarelli, Peter S. Back, Jihui Sha, James A. Wohlschlegel, Peter J. Bradley

PLOS Pathogens: published October 2, 2023 | https://doi.org/10.1371/journal.ppat.1011707

VP2 residue N142 of coxsackievirus A10 is critical for the interaction with KREMEN1 receptor and neutralizing antibodies and the pathogenicity in mice

Xue Li, Zeyu Liu, Xingyu Yan, Yuan Tian, Kexin Liu, Yue Zhao, Jiang Shao, Pei Hao, Chao Zhang

PLOS Pathogens: published October 3, 2023 | https://doi.org/10.1371/journal.ppat.1011662

Akkermansia muciniphila participates in the host protection against helminth-induced cardiac fibrosis via TLR2

Jiaqi Wang, Xiaolei Liu, Ruohang Sun, Hanhai Mao, Mingyuan Liu, Xuemin Jin

PLOS Pathogens: published October 3, 2023 | https://doi.org/10.1371/journal.ppat.1011683

Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis

Alžběta Motyčková, Luboš Voleman, Vladimíra Najdrová, Lenka Arbonová, Martin Benda, Vít Dohnálek, Natalia Janowicz, Ronald Malych, Róbert Šuťák, Thijs J. G. Ettema, Staffan Svärd, Courtney W. Stairs, Pavel Doležal

PLOS Pathogens: published October 4, 2023 | https://doi.org/10.1371/journal.ppat.1010773

Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection

Matilda J. Moström, Shan Yu, Dollnovan Tran, Frances M. Saccoccio, Cyril J. Versoza, Daniel Malouli, Anne Mirza, Sarah Valencia, Margaret Gilbert, Robert V. Blair, Scott Hansen, Peter Barry, Klaus Früh, Jeffrey D. Jensen, Susanne P. Pfeifer, Timothy F. Kowalik, Sallie R. Permar, Amitinder Kaur

PLOS Pathogens: published October 5, 2023 | https://doi.org/10.1371/journal.ppat.1011646

Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication

Mykola Pinkevych, Steffen S. Docken, Afam A. Okoye, Christine M. Fennessey, Gregory Q. Del Prete, Maria Pino, Justin L. Harper, Michael R. Betts, Mirko Paiardini, Brandon F. Keele, Miles P. Davenport

PLOS Pathogens: published October 6, 2023 | https://doi.org/10.1371/journal.ppat.1011660

Broad antagonism of coronaviruses nsp5 to evade the host antiviral responses by cleaving POLDIP3

Yang Wu, Mingwei Li, Jin Tian, Haoxin Yan, Yudi Pan, Hongyan Shi, Da Shi, Jianfei Chen, Longjun Guo, Li Feng

PLOS Pathogens: published October 6, 2023 | https://doi.org/10.1371/journal.ppat.1011702

Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarials

Oleksiy Tsebriy, Andrii Khomiak, Celia Miguel-Blanco, Penny C. Sparkes, Maurizio Gioli, Marco Santelli, Edgar Whitley, Francisco-Javier Gamo, Michael J. Delves

PLOS Pathogens: published October 6, 2023 | https://doi.org/10.1371/journal.ppat.1011711

Cellular iron governs the host response to malaria

Sarah K. Wideman, Joe N. Frost, Felix C. Richter, Caitlin Naylor, José M. Lopes, Nicole Viveiros, Megan R. Teh, Alexandra E. Preston, Natasha White, Shamsideen Yusuf, Simon J. Draper, Andrew E. Armitage, Tiago L. Duarte, Hal Drakesmith

PLOS Pathogens: published October 9, 2023 | https://doi.org/10.1371/journal.ppat.1011679

Phenotype and fate of liver-resident CD8 T cells during acute and chronic hepacivirus infection

Piyush Dravid, Satyapramod Murthy, Zayed Attia, Cole Cassady, Rahul Chandra, Sheetal Trivedi, Ashish Vyas, John Gridley, Brantley Holland, Anuradha Kumari, Arash Grakoui, John M. Cullen, Christopher M. Walker, Himanshu Sharma, Amit Kapoor

PLOS Pathogens: published October 9, 2023 | https://doi.org/10.1371/journal.ppat.1011697

The hybrid RAVE complex plays V-ATPase-dependent and -independent pathobiological roles in Cryptococcus neoformans

Jin-Tae Choi, Yeseul Choi, Yujin Lee, Seung-Heon Lee, Seun Kang, Kyung-Tae Lee, Yong-Sun Bahn

PLOS Pathogens: published October 9, 2023 | https://doi.org/10.1371/journal.ppat.1011721

Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses

Jay Lubow, Lisa M. Levoir, Duncan K. Ralph, Laura Belmont, Maya Contreras, Catiana H. Cartwright-Acar, Caroline Kikawa, Shruthi Kannan, Edgar Davidson, Veronica Duran, David E. Rebellon-Sanchez, Ana M. Sanz, Fernando Rosso, Benjamin J. Doranz, Shirit Einav, Frederick A. Matsen IV, Leslie Goo

PLOS Pathogens: published October 9, 2023 | https://doi.org/10.1371/journal.ppat.1011722

N-linked glycosylation of flavivirus E protein contributes to viral particle formation

Kotaro Ishida, Hirokazu Yagi, Yukinari Kato, Eiji Morita

PLOS Pathogens: published October 11, 2023 | https://doi.org/10.1371/journal.ppat.1011681

Dissection of key factors correlating with H5N1 avian influenza virus driven inflammatory lung injury of chicken identified by single-cell analysis

Manman Dai, Sufang Zhu, Zhihao An, Bowen You, Ziwei Li, Yongxiu Yao, Venugopal Nair, Ming Liao

PLOS Pathogens: published October 11, 2023 | https://doi.org/10.1371/journal.ppat.1011685

Mitochondrion of the Trypanosoma brucei long slender bloodstream form is capable of ATP production by substrate-level phosphorylation

Gergana Taleva, Michaela Husová, Brian Panicucci, Carolina Hierro-Yap, Erika Pineda, Marc Biran, Martin Moos, Petr Šimek, Falk Butter, Frédéric Bringaud, Alena Zíková

PLOS Pathogens: published October 11, 2023 | https://doi.org/10.1371/journal.ppat.1011699

Sepsis leads to lasting changes in phenotype and function of naïve CD8 T cells

Roger R. Berton, Patrick W. McGonagil, Isaac J. Jensen, Tiffany K. Ybarra, Gail A. Bishop, John T. Harty, Thomas S. Griffith, Vladimir P. Badovinac

PLOS Pathogens: published October 12, 2023 | https://doi.org/10.1371/journal.ppat.1011720

Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses

Hua Chen, Sheng Lin, Fanli Yang, Zimin Chen, Liyan Guo, Jing Yang, Xi Lin, Lingling Wang, Yanping Duan, Ao Wen, Xindan Zhang, Yushan Dai, Keqing Yin, Xin Yuan, Chongzhang Yu, Yarong He, Bin He, Yu Cao, Haohao Dong, Jian Li, Qi Zhao, Quan Liu, Guangwen Lu

PLOS Pathogens: published October 13, 2023 | https://doi.org/10.1371/journal.ppat.1011694

SARS-CoV-2 suppresses TLR4-induced immunity by dendritic cells via C-type lectin receptor DC-SIGN

Lieve E. H. van der Donk, Marta Bermejo-Jambrina, John L. van Hamme, Mette M. W. Volkers, Ad C. van Nuenen, Neeltje A. Kootstra, Teunis B. H. Geijtenbeek

PLOS Pathogens: published October 16, 2023 | https://doi.org/10.1371/journal.ppat.1011735

Preexisting helminth challenge exacerbates infection and reactivation of gammaherpesvirus in tissue resident macrophages

Christina M. Zarek, Chaitanya Dende, Jaime Coronado, Mihir Pendse, Phillip Dryden, Lora V. Hooper, Tiffany A. Reese

PLOS Pathogens: published October 17, 2023 | https://doi.org/10.1371/journal.ppat.1011691

A regulatory role for the redox status of the pepino mosaic virus coat protein

Eduardo Méndez-López, Miguel A. Aranda

PLOS Pathogens: published October 18, 2023 | https://doi.org/10.1371/journal.ppat.1011732

Serpin-1a and serpin-6 regulate the Toll pathway immune homeostasis by synergistically inhibiting the Spätzle-processing enzyme CLIP2 in silkworm, Bombyx mori

Huawei Liu, Jiahui Xu, Luoling Wang, Pengchao Guo, Zhangchen Tang, Xiaotong Sun, Xin Tang, Wei Wang, Lingyan Wang, Yang Cao, Qingyou Xia, Ping Zhao

PLOS Pathogens: published October 18, 2023 | https://doi.org/10.1371/journal.ppat.1011740

Regulatory T cell-like response to SARS-CoV-2 in Jamaican fruit bats (Artibeus jamaicensis) transduced with human ACE2

Bradly Burke, Savannah M. Rocha, Shijun Zhan, Miles Eckley, Clara Reasoner, Amin Addetia, Juliette Lewis, Anna Fagre, Phillida A. Charley, Juergen A. Richt, Susan R. Weiss, Ronald B. Tjalkens, David Veesler, Tawfik Aboellail, Tony Schountz

PLOS Pathogens: published October 19, 2023 | https://doi.org/10.1371/journal.ppat.1011728

Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model

Claire E. Otero, Richard Barfield, Elizabeth Scheef, Cody S. Nelson, Nicole Rodgers, Hsuan-Yuan Wang, Matilda J. Moström, Tabitha D. Manuel, Julian Sass, Kimberli Schmidt, Husam Taher, Courtney Papen, Lesli Sprehe, Savannah Kendall, Angel Davalos, Peter A. Barry, Klaus Früh, Justin Pollara, Daniel Malouli, Cliburn Chan, Amitinder Kaur, Sallie R. Permar

PLOS Pathogens: published October 23, 2023 | https://doi.org/10.1371/journal.ppat.1011378

G9a and Sirtuin6 epigenetically modulate host cholesterol accumulation to facilitate mycobacterial survival

Praveen Prakhar, Bharat Bhatt, Gaurav Kumar Lohia, Awantika Shah, Tanushree Mukherjee, Ullas Kolthur-Seetharam, Nagalingam R. Sundaresan, Raju S. Rajmani, Kithiganahalli Narayanaswamy Balaji

PLOS Pathogens: published October 23, 2023 | https://doi.org/10.1371/journal.ppat.1011731

Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response

Wei-Wei Li, Xu-Xu Fan, Zi-Xiang Zhu, Xue-Jing Cao, Zhao-Yu Zhu, Dan-Shi Pei, Yi-Zhuo Wang, Ji-Yan Zhang, Yan-Yi Wang, Hai-Xue Zheng

PLOS Pathogens: published October 23, 2023 | https://doi.org/10.1371/journal.ppat.1011742

Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo

Shannon L. Kordus, Heather K. Kroh, Rubén Cano Rodríguez, Rebecca A. Shrem, F. Christopher Peritore-Galve, John A. Shupe, Brian E. Wadzinski, D. Borden Lacy, Benjamin W. Spiller

PLOS Pathogens: published October 23, 2023 | https://doi.org/10.1371/journal.ppat.1011496

Divergence of TORC1-mediated stress response leads to novel acquired stress resistance in a pathogenic yeast

Jinye Liang, Hanxi Tang, Lindsey F. Snyder, Christopher E. Youngstrom, Bin Z. He

PLOS Pathogens: published October 23, 2023 | https://doi.org/10.1371/journal.ppat.1011748

Periodontitis promotes bacterial extracellular vesicle-induced neuroinflammation in the brain and trigeminal ganglion

Jae Yeong Ha, Jiwon Seok, Suk-Jeong Kim, Hye-Jin Jung, Ka-Young Ryu, Michiko Nakamura, Il-Sung Jang, Su-Hyung Hong, Youngkyun Lee, Heon-Jin Lee

PLOS Pathogens: published October 23, 2023 | https://doi.org/10.1371/journal.ppat.1011743

High throughput analysis of B cell dynamics and neutralizing antibody development during immunization with a novel clade C HIV-1 envelope

Rohini Mopuri, Sarah Welbourn, Tysheena Charles, Pooja Ralli-Jain, David Rosales, Samantha Burton, Areeb Aftab, Kirti Karunakaran, Kathryn Pellegrini, William Kilembe, Etienne Karita, Sandrasegaram Gnanakaran, Amit A. Upadhyay, Steven E. Bosinger, Cynthia A. Derdeyn

PLOS Pathogens: published October 25, 2023 | https://doi.org/10.1371/journal.ppat.1011717

Virally encoded interleukin-6 facilitates KSHV replication in monocytes and induction of dysfunctional macrophages

Michiko Shimoda, Tomoki Inagaki, Ryan R. Davis, Alexander Merleev, Clifford G. Tepper, Emanual Maverakis, Yoshihiro Izumiya

PLOS Pathogens: published October 26, 2023 | https://doi.org/10.1371/journal.ppat.1011703

Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles

Anna Malyshkina, Wibke Bayer, Philip Podschwadt, Lucas Otto, Zehra Karakoese, Kathrin Sutter, Kirsten Bruderek, Baoxiao Wang, Kerry J. Lavender, Mario L. Santiago, Pia Madeleine Leipe, Carina Elsner, Stefan Esser, Sven Brandau, Matthias Gunzer, Ulf Dittmer

PLOS Pathogens: published October 26, 2023 | https://doi.org/10.1371/journal.ppat.1011725

Sugarcane streak mosaic virus P1 protein inhibits unfolded protein response through direct suppression of bZIP60U splicing

Kun Zhang, Tianxiao Gu, Xiaowei Xu, Haifeng Gan, Lang Qin, Chenwei Feng, Zhen He

PLOS Pathogens: published October 26, 2023 | https://doi.org/10.1371/journal.ppat.1011738

Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoes

Wei-Xin Chin, Hao Yuin Kong, Isabelle Xin Yu Zhu, Zi Yun Teo, Regina Faruk, Regina Ching Hua Lee, Si Xian Ho, Zhen Qin Aw, Bowen Yi, Xin Jun Hou, Antson Kiat Yee Tan, Thinesshwary Yogarajah, Roland G. Huber, Yu Cai, Yue Wan, Justin Jang Hann Chu

PLOS Pathogens: published October 26, 2023 | https://doi.org/10.1371/journal.ppat.1011753

The influence of the larval microbiome on susceptibility to Zika virus is mosquito genotype-dependent

Anastasia Accoti, Laura C. Multini, Babakar Diouf, Margaret Becker, Julia Vulcan, Massamba Sylla, Dianne Y. Yap, Kamil Khanipov, Mawlouth Diallo, Alioune Gaye, Laura B. Dickson

PLOS Pathogens: published October 30, 2023 | https://doi.org/10.1371/journal.ppat.1011727

Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization

Rajesh P. Ringe, Philippe Colin, Gabriel Ozorowski, Joel D. Allen, Anila Yasmeen, Gemma E. Seabright, Jeong Hyun Lee, Aleksandar Antanasijevic, Kimmo Rantalainen, Thomas Ketas, John P. Moore, Andrew B. Ward, Max Crispin, P. J. Klasse

PLOS Pathogens: published October 30, 2023 | https://doi.org/10.1371/journal.ppat.1011601

Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in C. elegans

Mohamad A. Nasrallah, Nicholas D. Peterson, Elizabeth S. Szumel, Pengpeng Liu, Amanda L. Page, Samantha Y. Tse, Khursheed A. Wani, Claire E. Tocheny, Read Pukkila-Worley

PLOS Pathogens: published October 31, 2023 | https://doi.org/10.1371/journal.ppat.1011730

The Aspergillus fumigatus UPR is variably activated across nutrient and host environments and is critical for the establishment of corneal infection

Manali M. Kamath, Jorge D. Lightfoot, Emily M. Adams, Ryan M. Kiser, Becca L. Wells, Kevin K. Fuller

PLOS Pathogens: published October 31, 2023 | https://doi.org/10.1371/journal.ppat.1011435

Correction: Viral burden is associated with age, vaccination, and viral variant in a population-representative study of SARS-CoV-2 that accounts for time-since-infection-related sampling bias

Helen R. Fryer, Tanya Golubchik, Matthew Hall, Christophe Fraser, Robert Hinch, Luca Ferretti, Laura Thomson, Anel Nurtay, Lorenzo Pellis, Thomas House, George MacIntyre-Cockett, Amy Trebes, David Buck, Paolo Piazza, Angie Green, Lorne J Lonie, Darren Smith, Matthew Bashton, Matthew Crown, Andrew Nelson, Clare M. McCann, Mohammed Adnan Tariq, Claire J. Elstob, Rui Nunes Dos Santos, Zack Richards, Xin Xhang, Joseph Hawley, Mark R. Lee, Priscilla Carrillo-Barragan, Isobel Chapman, Sarah Harthern-Flint, The COVID-19 Genomics UK (COG-UK) consortium, David Bonsall, Katrina A. Lythgoe

PLOS Pathogens: published October 6, 2023 | https://doi.org/10.1371/journal.ppat.1011706

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Correction: Understanding antibody-dependent enhancement in dengue: Are afucosylated IgG1s a concern?

Andrew Teo, Hao Dong Tan, Thomas Loy, Po Ying Chia, Caroline Lin Lin Chua

PLOS Pathogens: published October 18, 2023 | https://doi.org/10.1371/journal.ppat.1011736

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Editorial Note: Viral-mediated activation and inhibition of programmed cell death

The PLOS Pathogens Editors

PLOS Pathogens: published October 10, 2023 | https://doi.org/10.1371/journal.ppat.1011712

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