Yersinia pestis induces, resists and then consolidates the formation of a bactericidal matrix in the flea’s proventriculus, which hastens its transmission to the mammalian host. In this fluorescence image, myriad of GFP+ Y. pestis are entrapped in a mass fulfilling the anterior spineless region and the spined region (that autofluoresces in yellow) of the proventriculus. Here, the mass also extends in the esophagus. Dewitte et al
Image Credit: Sebbane F
Pearls
The gut mycobiome: The overlooked constituent of clinical outcomes and treatment complications in patients with cancer and other immunosuppressive conditions
PLOS Pathogens: published April 2, 2020 | https://doi.org/10.1371/journal.ppat.1008353
Japanese encephalitis virus and its mechanisms of neuroinvasion
PLOS Pathogens: published April 2, 2020 | https://doi.org/10.1371/journal.ppat.1008260
Fine-tuning a blunt tool: Regulation of viral host shutoff RNases
PLOS Pathogens: published April 8, 2020 | https://doi.org/10.1371/journal.ppat.1008385
The clue is in the lipid A: Rapid detection of colistin resistance
PLOS Pathogens: published April 9, 2020 | https://doi.org/10.1371/journal.ppat.1008331
In sickness and health: Effects of gut microbial metabolites on human physiology
PLOS Pathogens: published April 9, 2020 | https://doi.org/10.1371/journal.ppat.1008370
The entanglement between flaviviruses and ER-shaping proteins
PLOS Pathogens: published April 16, 2020 | https://doi.org/10.1371/journal.ppat.1008389
Bats reveal the true power of influenza A virus adaptability
PLOS Pathogens: published April 16, 2020 | https://doi.org/10.1371/journal.ppat.1008384
Drosophila as a model for the gut microbiome
PLOS Pathogens: published April 23, 2020 | https://doi.org/10.1371/journal.ppat.1008398
Genetic interaction analysis comes to the diploid human pathogen Candida albicans
PLOS Pathogens: published April 23, 2020 | https://doi.org/10.1371/journal.ppat.1008399
Battling brain-eating amoeba: Enigmas surrounding immunity to Naegleria fowleri
PLOS Pathogens: published April 23, 2020 | https://doi.org/10.1371/journal.ppat.1008406
Citrus tristeza virus: A large RNA virus with complex biology turned into a valuable tool for crop protection
PLOS Pathogens: published April 30, 2020 | https://doi.org/10.1371/journal.ppat.1008416
Mycobacterium simiae: Harmless colonizer or deadly pathogen?
PLOS Pathogens: published April 30, 2020 | https://doi.org/10.1371/journal.ppat.1008418
Review
Competent but complex communication: The phenomena of pheromone-responsive plasmids
PLOS Pathogens: published April 2, 2020 | https://doi.org/10.1371/journal.ppat.1008310
Research Articles
Discovery and characterization of a Gram-positive Pel polysaccharide biosynthetic gene cluster
PLOS Pathogens: published April 1, 2020 | https://doi.org/10.1371/journal.ppat.1008281
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Chemical intervention of influenza virus mRNA nuclear export
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EAT-18 is an essential auxiliary protein interacting with the non-alpha nAChR subunit EAT-2 to form a functional receptor
PLOS Pathogens: published April 3, 2020 | https://doi.org/10.1371/journal.ppat.1008396
ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response
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CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus
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Dual metabolomic profiling uncovers Toxoplasma manipulation of the host metabolome and the discovery of a novel parasite metabolic capability
PLOS Pathogens: published April 7, 2020 | https://doi.org/10.1371/journal.ppat.1008432
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Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner
PLOS Pathogens: published April 13, 2020 | https://doi.org/10.1371/journal.ppat.1008426
Multiple Wolbachia strains provide comparative levels of protection against dengue virus infection in Aedes aegypti
PLOS Pathogens: published April 13, 2020 | https://doi.org/10.1371/journal.ppat.1008433
Transcytosis subversion by M cell-to-enterocyte spread promotes Shigella flexneri and Listeria monocytogenes intracellular bacterial dissemination
PLOS Pathogens: published April 13, 2020 | https://doi.org/10.1371/journal.ppat.1008446
TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner
PLOS Pathogens: published April 13, 2020 | https://doi.org/10.1371/journal.ppat.1008507
Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes
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Fatal progression of experimental visceral leishmaniasis is associated with intestinal parasitism and secondary infection by commensal bacteria, and is delayed by antibiotic prophylaxis
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Characterizing Emerging Canine H3 Influenza Viruses
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Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission
PLOS Pathogens: published April 15, 2020 | https://doi.org/10.1371/journal.ppat.1008395
Human cytomegalovirus long noncoding RNA4.9 regulates viral DNA replication
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A refined model of how Yersinia pestis produces a transmissible infection in its flea vector
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Cofactor and glycosylation preferences for in vitro prion conversion are predominantly determined by strain conformation
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Gut microbiota promotes host resistance to low-temperature stress by stimulating its arginine and proline metabolism pathway in adult Bactrocera dorsalis
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Verticillium dahliae chromatin remodeling facilitates the DNA damage repair in response to plant ROS stress
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Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers
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The TIR-domain containing effectors BtpA and BtpB from Brucella abortus impact NAD metabolism
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Role of MPK4 in pathogen-associated molecular pattern-triggered alternative splicing in Arabidopsis
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Matrix metalloproteinase 9 facilitates Zika virus invasion of the testis by modulating the integrity of the blood-testis barrier
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Loss of tetherin antagonism by Nef impairs SIV replication during acute infection of rhesus macaques
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Contribution of STAT1 to innate and adaptive immunity during type I interferon-mediated lethal virus infection
PLOS Pathogens: published April 20, 2020 | https://doi.org/10.1371/journal.ppat.1008525
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13
PLOS Pathogens: published April 20, 2020 | https://doi.org/10.1371/journal.ppat.1008482
PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease
PLOS Pathogens: published April 21, 2020 | https://doi.org/10.1371/journal.ppat.1008474
Natural killer cells expanded in vivo or ex vivo with IL-15 overcomes the inherent susceptibility of CAST mice to lethal infection with orthopoxviruses
PLOS Pathogens: published April 22, 2020 | https://doi.org/10.1371/journal.ppat.1008505
Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration
PLOS Pathogens: published April 22, 2020 | https://doi.org/10.1371/journal.ppat.1008496
Non-pathogenic Escherichia coli acquires virulence by mutating a growth-essential LPS transporter
PLOS Pathogens: published April 23, 2020 | https://doi.org/10.1371/journal.ppat.1008469
The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection
PLOS Pathogens: published April 23, 2020 | https://doi.org/10.1371/journal.ppat.1008464
High expression of JC polyomavirus-encoded microRNAs in progressive multifocal leukoencephalopathy tissues and its repressive role in virus replication
PLOS Pathogens: published April 23, 2020 | https://doi.org/10.1371/journal.ppat.1008523
Characterization of a fungal competition factor: Production of a conidial cell-wall associated antifungal peptide
PLOS Pathogens: published April 23, 2020 | https://doi.org/10.1371/journal.ppat.1008518
Epithelium intrinsic vitamin A signaling co-ordinates pathogen clearance in the gut via IL-18
PLOS Pathogens: published April 24, 2020 | https://doi.org/10.1371/journal.ppat.1008360
RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit Hantaan orthohantavirus replication
PLOS Pathogens: published April 24, 2020 | https://doi.org/10.1371/journal.ppat.1008483
Broad spectrum immunomodulatory effects of Anopheles gambiae microRNAs and their use for transgenic suppression of Plasmodium
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Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila
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Corrections
Correction: EBV-miR-BART1-5P activates AMPK/mTOR/HIF1 pathway via a PTEN independent manner to promote glycolysis and angiogenesis in nasopharyngeal carcinoma
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