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Table of Contents

April 2017

Scanning electron micrograph depicting Shigella flexneri captured by host cell filopodia. MicroRNA miR-29b-2-5p, through the repression of its direct target UNC5C, dramatically increases host cell filopodia, which promote bacterial capture and internalization. Ana Eulalio et al.

Image Credit: Ana Eulalio and Miguel Mano

Pearls

Rotavirus genome replication: Some assembly required

Courtney P. Long, Sarah M. McDonald

Elucidating the structure of an infectious protein

Markus Zweckstetter, Jesús R. Requena, Holger Wille

Review

Research Articles

IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection

Branka Popovic, Mijo Golemac, Jürgen Podlech, Jelena Zeleznjak, Lidija Bilic-Zulle, Miodrag L. Lukic, Luka Cicin-Sain, Matthias J. Reddehase, Tim Sparwasser, Astrid Krmpotic, Stipan Jonjic

Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses

Hadar Israeli, Hadas Cohen-Dvashi, Anastasiya Shulman, Amir Shimon, Ron Diskin

IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria

Flora Reverchon, Stéphane Mortaud, Maëliss Sivoyon, Isabelle Maillet, Anthony Laugeray, Jennifer Palomo, Céline Montécot, Améziane Herzine, Sandra Meme, William Meme, François Erard, Bernhard Ryffel, Arnaud Menuet, Valérie F. J. Quesniaux

Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency

Giuseppe Mariggiò, Sandra Koch, Guigen Zhang, Magdalena Weidner-Glunde, Jessica Rückert, Semra Kati, Susann Santag, Thomas F. Schulz

Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division

Kannan Venugopal, Elisabeth Werkmeister, Nicolas Barois, Jean-Michel Saliou, Anais Poncet, Ludovic Huot, Fabien Sindikubwabo, Mohamed Ali Hakimi, Gordon Langsley, Frank Lafont, Sabrina Marion

A second wave of Salmonella T3SS1 activity prolongs the lifespan of infected epithelial cells

Ciaran E. Finn, Audrey Chong, Kendal G. Cooper, Tregei Starr, Olivia Steele-Mortimer

The role of microsporidian polar tube protein 4 (PTP4) in host cell infection

Bing Han, Valérie Polonais, Tatsuki Sugi, Rama Yakubu, Peter M. Takvorian, Ann Cali, Keith Maier, Mengxian Long, Matthew Levy, Herbert B. Tanowitz, Guoqing Pan, Frédéric Delbac, Zeyang Zhou, Louis M. Weiss

Gre factors-mediated control of hilD transcription is essential for the invasion of epithelial cells by Salmonella enterica serovar Typhimurium

Tania Gaviria-Cantin, Youssef El Mouali, Soazig Le Guyon, Ute Römling, Carlos Balsalobre

Activated entomopathogenic nematode infective juveniles release lethal venom proteins

Dihong Lu, Marissa Macchietto, Dennis Chang, Mirayana M. Barros, James Baldwin, Ali Mortazavi, Adler R. Dillman

Levels of HIV-1 persistence on antiretroviral therapy are not associated with markers of inflammation or activation

Rajesh T. Gandhi, Deborah K. McMahon, Ronald J. Bosch, Christina M. Lalama, Joshua C. Cyktor, Bernard J. Macatangay, Charles R. Rinaldo, Sharon A. Riddler, Evelyn Hogg, Catherine Godfrey, Ann C. Collier, Joseph J. Eron, John W. Mellors, ACTG A5321 Team

Insertion of a ligand to HER2 in gB retargets HSV tropism and obviates the need for activation of the other entry glycoproteins

Biljana Petrovic, Tatiana Gianni, Valentina Gatta, Gabriella Campadelli-Fiume

Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression

Sarah R. Beattie, Kenneth M. K. Mark, Arsa Thammahong, Laure Nicolas Annick Ries, Sourabh Dhingra, Alayna K. Caffrey-Carr, Chao Cheng, Candice C. Black, Paul Bowyer, Michael J. Bromley, Joshua J. Obar, Gustavo H. Goldman, Robert A. Cramer

Mycobacterium marinum antagonistically induces an autophagic response while repressing the autophagic flux in a TORC1- and ESX-1-dependent manner

Elena Cardenal-Muñoz, Sonia Arafah, Ana Teresa López-Jiménez, Sébastien Kicka, Alexandra Falaise, Frauke Bach, Olivier Schaad, Jason S. King, Monica Hagedorn, Thierry Soldati

GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome

Ying Nie, Yong Ran, Hong-Yan Zhang, Zhe-Fu Huang, Zhao-Yi Pan, Su-Yun Wang, Yan-Yi Wang

RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection

Jeffrey Downey, Erwan Pernet, François Coulombe, Benoit Allard, Isabelle Meunier, Joanna Jaworska, Salman Qureshi, Donald C. Vinh, James G. Martin, Philippe Joubert, Maziar Divangahi

Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9

Sarah A. Tursi, Ernest Y. Lee, Nicole J. Medeiros, Michael H. Lee, Lauren K. Nicastro, Bettina Buttaro, Stefania Gallucci, Ronald Paul Wilson, Gerard C. L. Wong, Çagla Tükel

Novel decay dynamics revealed for virus-mediated drug activation in cytomegalovirus infection

Jessica Rose, Vincent C. Emery, Deepali Kumar, Anders Asberg, Anders Hartmann, Alan G. Jardine, Angelo A. Bignamini, Atul Humar, Avidan U. Neumann

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Analysis of host microRNA function uncovers a role for miR-29b-2-5p in Shigella capture by filopodia

Ushasree Sunkavalli, Carmen Aguilar, Ricardo Jorge Silva, Malvika Sharan, Ana Rita Cruz, Caroline Tawk, Claire Maudet, Miguel Mano, Ana Eulalio

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