Skip to main content
Advertisement
Table of Contents

September 2012

A novel rhabdovirus, Bas-Congo virus (BASV), has been identified in association with an outbreak of hemorrhagic fever in a remote village in Bas-Congo, Africa (see Grard et al., doi:10.1371/journal.ppat.1002924). A phylogenetic tree of rhabdoviruses and silhouettes of their associated host species are superimposed on top of a map of Africa showing countries affected by viral hemorrhagic fever (in color). The orange-red sphere designates both the position of BASV in the phylogenetic tree and the geographic origin of the BASV-associated outbreak. The photo depicts spontaneous bleeding from the arm of an affected patient with hemorrhagic fever.

Image Credit: Charles Chiu, University of California, San Francisco and Eric Leroy, Centre International de Recherches Médicales de Franceville.

Opinion

The Battle over mTOR: An Emerging Theatre in Host–Pathogen Immunity

Sunil Martin, Bhaskar Saha, James L. Riley

Review

Research Articles

Deep Sequencing of Antiviral T-Cell Responses to HCMV and EBV in Humans Reveals a Stable Repertoire That Is Maintained for Many Years

P. L. Klarenbeek, E. B. M. Remmerswaal, I. J. M. ten Berge, M. E. Doorenspleet, B. D. C. van Schaik, R. E. E. Esveldt, S. D. Koch, A. ten Brinke, A. H. C. van Kampen, F. J. Bemelman, P. P. Tak, F. Baas, N. de Vries, R. A. W. van Lier

A Novel Rhabdovirus Associated with Acute Hemorrhagic Fever in Central Africa

Gilda Grard, Joseph N. Fair, Deanna Lee, Elizabeth Slikas, Imke Steffen, Jean-Jacques Muyembe, Taylor Sittler, Narayanan Veeraraghavan, J. Graham Ruby, Chunlin Wang, Maria Makuwa, Prime Mulembakani, Robert B. Tesh, Jonna Mazet, Anne W. Rimoin, Travis Taylor, Bradley S. Schneider, Graham Simmons, Eric Delwart, Nathan D. Wolfe, Charles Y. Chiu, Eric M. Leroy

Related Articles

Kaposi's Sarcoma Herpesvirus K15 Protein Contributes to Virus-Induced Angiogenesis by Recruiting PLCγ1 and Activating NFAT1-dependent RCAN1 Expression

Kiran Bala, Raffaella Bosco, Silvia Gramolelli, Darya A. Haas, Semra Kati, Marcel Pietrek, Anika Hävemeier, Yuri Yakushko, Vivek Vikram Singh, Oliver Dittrich-Breiholz, Michael Kracht, Thomas F. Schulz

Complexes of Vesicular Stomatitis Virus Matrix Protein with Host Rae1 and Nup98 Involved in Inhibition of Host Transcription

Karishma R. Rajani, Elizabeth L. Pettit Kneller, Margie O. McKenzie, David A. Horita, Jeff W. Chou, Douglas S. Lyles

Primary and Secondary siRNAs in Geminivirus-induced Gene Silencing

Michael Aregger, Basanta K. Borah, Jonathan Seguin, Rajendran Rajeswaran, Ekaterina G. Gubaeva, Anna S. Zvereva, David Windels, Franck Vazquez, Todd Blevins, Laurent Farinelli, Mikhail M. Pooggin

Mycobacterium marinum Causes a Latent Infection that Can Be Reactivated by Gamma Irradiation in Adult Zebrafish

Mataleena Parikka, Milka M. Hammarén, Sanna-Kaisa E. Harjula, Nicholas J. A. Halfpenny, Kaisa E. Oksanen, Marika J. Lahtinen, Elina T. Pajula, Antti Iivanainen, Marko Pesu, Mika Rämet

The Single-Nucleotide Resolution Transcriptome of Pseudomonas aeruginosa Grown in Body Temperature

Omri Wurtzel, Deborah R. Yoder-Himes, Kook Han, Ajai A. Dandekar, Sarit Edelheit, E. Peter Greenberg, Rotem Sorek, Stephen Lory

Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis

Yanjia J. Zhang, Thomas R. Ioerger, Curtis Huttenhower, Jarukit E. Long, Christopher M. Sassetti, James C. Sacchettini, Eric J. Rubin

Related Articles

Comparative Pathogenomics Reveals Horizontally Acquired Novel Virulence Genes in Fungi Infecting Cereal Hosts

Donald M. Gardiner, Megan C. McDonald, Lorenzo Covarelli, Peter S. Solomon, Anca G. Rusu, Mhairi Marshall, Kemal Kazan, Sukumar Chakraborty, Bruce A. McDonald, John M. Manners

H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

Erhard van der Vries, Patrick J. Collins, Sebastien G. Vachieri, Xiaoli Xiong, Junfeng Liu, Philip A. Walker, Lesley F. Haire, Alan J. Hay, Martin Schutten, Albert D. M. E. Osterhaus, Steve R. Martin, Charles A. B. Boucher, John J. Skehel, Steve J. Gamblin

Very Long O-antigen Chains Enhance Fitness during Salmonella-induced Colitis by Increasing Bile Resistance

Robert W. Crawford, A. Marijke Keestra, Sebastian E. Winter, Mariana N. Xavier, Renée M. Tsolis, Vladimir Tolstikov, Andreas J. Bäumler

A Cell-Based Screen Reveals that the Albendazole Metabolite, Albendazole Sulfone, Targets Wolbachia

Laura R. Serbus, Frederic Landmann, Walter M. Bray, Pamela M. White, Jordan Ruybal, R. Scott Lokey, Alain Debec, William Sullivan

Relacin, a Novel Antibacterial Agent Targeting the Stringent Response

Ezequiel Wexselblatt, Yaara Oppenheimer-Shaanan, Ilana Kaspy, Nir London, Ora Schueler-Furman, Eylon Yavin, Gad Glaser, Joshua Katzhendler, Sigal Ben-Yehuda

Loss of Effector and Anti-Inflammatory Natural Killer T Lymphocyte Function in Pathogenic Simian Immunodeficiency Virus Infection

Namita Rout, Justin Greene, Simon Yue, David O'Connor, R. Paul Johnson, James G. Else, Mark A. Exley, Amitinder Kaur

Myeloid Infection Links Epithelial and B Cell Tropisms of Murid Herpesvirus-4

Bruno Frederico, Ricardo Milho, Janet S. May, Laurent Gillet, Philip G. Stevenson

A Role for microRNA-155 Modulation in the Anti-HIV-1 Effects of Toll-Like Receptor 3 Stimulation in Macrophages

Gokul Swaminathan, Fiorella Rossi, Luz-Jeannette Sierra, Archana Gupta, Sonia Navas-Martín, Julio Martín-García

A Unique Protein Phosphatase with Kelch-Like Domains (PPKL) in Plasmodium Modulates Ookinete Differentiation, Motility and Invasion

David S. Guttery, Benoit Poulin, David J. P. Ferguson, Balázs Szöőr, Bill Wickstead, Paula L. Carroll, Chandra Ramakrishnan, Declan Brady, Eva-Maria Patzewitz, Ursula Straschil, Lev Solyakov, Judith L. Green, Robert E. Sinden, Andrew B. Tobin, Anthony A. Holder, Rita Tewari

Vector-Borne Transmission Imposes a Severe Bottleneck on an RNA Virus Population

Naomi L. Forrester, Mathilde Guerbois, Robert L. Seymour, Heidi Spratt, Scott C. Weaver

PDGF Receptor-α Does Not Promote HCMV Entry into Epithelial and Endothelial Cells but Increased Quantities Stimulate Entry by an Abnormal Pathway

Adam L. Vanarsdall, Todd W. Wisner, Hetian Lei, Andrius Kazlauskas, David C. Johnson

The Legionella IcmSW Complex Directly Interacts with DotL to Mediate Translocation of Adaptor-Dependent Substrates

Molly C. Sutherland, Thuy Linh Nguyen, Victor Tseng, Joseph P. Vogel

Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome

Barbara Selisko, Supanee Potisopon, Rym Agred, Stéphane Priet, Isabelle Varlet, Yann Thillier, Corinne Sallamand, Françoise Debart, Jean-Jacques Vasseur, Bruno Canard

Slc15a4, a Gene Required for pDC Sensing of TLR Ligands, Is Required to Control Persistent Viral Infection

Amanda L. Blasius, Philippe Krebs, Brian M. Sullivan, Michael B. Oldstone, Daniel L. Popkin

Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism

Shridhar Bale, Jean-Philippe Julien, Zachary A. Bornholdt, Christopher R. Kimberlin, Peter Halfmann, Michelle A. Zandonatti, John Kunert, Gerard J. A. Kroon, Yoshihiro Kawaoka, Ian J. MacRae, Ian A. Wilson, Erica Ollmann Saphire

Phase Variable O Antigen Biosynthetic Genes Control Expression of the Major Protective Antigen and Bacteriophage Receptor in Vibrio cholerae O1

Kimberley D. Seed, Shah M. Faruque, John J. Mekalanos, Stephen B. Calderwood, Firdausi Qadri, Andrew Camilli

Structure and Assembly of a Trans-Periplasmic Channel for Type IV Pili in Neisseria meningitidis

Jamie-Lee Berry, Marie M. Phelan, Richard F. Collins, Tomas Adomavicius, Tone Tønjum, Stefan A. Frye, Louise Bird, Ray Owens, Robert C. Ford, Lu-Yun Lian, Jeremy P. Derrick

BZLF1 Governs CpG-Methylated Chromatin of Epstein-Barr Virus Reversing Epigenetic Repression

Anne Woellmer, Jose M. Arteaga-Salas, Wolfgang Hammerschmidt

The ESCRT Machinery Is Recruited by the Viral BFRF1 Protein to the Nucleus-Associated Membrane for the Maturation of Epstein-Barr Virus

Chung-Pei Lee, Po-Ting Liu, Hsiu-Ni Kung, Mei-Tzu Su, Huey-Huey Chua, Yu-Hsin Chang, Chou-Wei Chang, Ching-Hwa Tsai, Fu-Tong Liu, Mei-Ru Chen

Unbiased Mutagenesis of MHV68 LANA Reveals a DNA-Binding Domain Required for LANA Function In Vitro and In Vivo

Clinton R. Paden, J. Craig Forrest, Scott A. Tibbetts, Samuel H. Speck

Real-time Transcriptional Profiling of Cellular and Viral Gene Expression during Lytic Cytomegalovirus Infection

Lisa Marcinowski, Michael Lidschreiber, Lukas Windhager, Martina Rieder, Jens B. Bosse, Bernd Rädle, Thomas Bonfert, Ildiko Györy, Miranda de Graaf, Olivia Prazeres da Costa, Philip Rosenstiel, Caroline C. Friedel, Ralf Zimmer, Zsolt Ruzsics, Lars Dölken

Ifitm3 Limits the Severity of Acute Influenza in Mice

Charles C. Bailey, I-Chueh Huang, Christina Kam, Michael Farzan

OX40 Facilitates Control of a Persistent Virus Infection

Tobias Boettler, Friedrich Moeckel, Yang Cheng, Maximilian Heeg, Shahram Salek-Ardakani, Shane Crotty, Michael Croft, Matthias G. von Herrath