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Current Issue June 2020

05/28/2020

Research Article

Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass

Osteocalcin (Ocn) is the most abundant non-collagenous protein in bone. Here, Moriishi et al generate Ocn-deficient mice and show that Ocn is not required for bone formation, but is required for optimal bone quality and strength. The authors further find normal glucose metabolism, testosterone synthesis and muscle mass in Ocn-deficient mice.

Image credit: Takeshi Moriishi and colleagues

Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass

05/28/2020

Research Article

An Osteocalcin-deficient mouse strain without endocrine abnormalities

Diegel et al investigate the nonskeletal effects of osteocalcin (Ocn) by generating a new strain of Ocn knockout mice. The authors find the Ocn-deficient mice they created do not significantly differ from wild-type mice for three examined phenotypes: bone strength, blood glucose and male fertility. 

Image credit: Cassandra R. Diegel and colleagues

An Osteocalcin-deficient mouse strain without endocrine abnormalities

05/08/2020

Research Article

An EHBP-1-SID-3-DYN-1 axis promotes membranous tubule fission during endocytic recycling

Jinghu Gao, Linyue Zhao et al identify SID-3 as a new interactor of EHBP-1, a protein that functions with RAB-10 to generate and maintain recycling endosomal tubules. The authors find that SID-3 functions downstream of EHBP-1 to encourage membrane scission, and that ectopic expression of DYN-1 improves recycling transport in SID-3-depleted cells. 

An EHBP-1-SID-3-DYN-1 axis promotes membranous tubule fission during endocytic recycling

Image credit: Gao, Zhao and colleagues

04/23/2020

Review

Placental imprinting: Emerging mechanisms and functions

Courtney Hanna describes novel approaches regulating imprinted genes, those that are expressed from only one copy, depending on which parent they were inherited from, in mouse models.

Placental imprinting: Emerging mechanisms and functions

Image credit: Courtney W. Hanna

04/16/2020

Review

Deconstructing cerebellar development cell by cell

Max J. van Essen, Samuel Nayler and colleagues describe new discoveries of developmental mechanisms that generate cerebellar neural diversity, using single-cell sequencing in mouse and parallel human studies.

Deconstructing cerebellar development cell by cell

Image credit: van Essen, Nayler and colleagues

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