Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings

Releasing sterile males for pest control can be successful, but is challenging when the target population is large or the species difficult to rear. Here, Geci et al build on previous work to show that Y-linked editors to kill or sterilise female descendants can be used in more efficient gene drive designs that would spread over successive generations beyond the region of release.

Yu & Guo report that fruit flies are most attracted to chewy food, rather than those with too low or too high stiffness. A group of mechanosensory neurons on the fly proboscis are activated during active probing on food surface and promote ingestion by activating the sweet-sensing neurons.

K+ homeostasis is critical for maintaining healthy levels of neuronal activity. Lones & DiAntonio find a transcriptional target that can regulate K+ buffering in cortex glia and modulate seizure susceptibility in multiple Drosophila models of epilepsy.