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Htt is a repressor of Abl activity required for APP-induced axonal growth

January 19, 2021

Htt is a repressor of Abl activity required for APP-induced axonal growth

Htt, related to Huntington’s disease, and Appl, related to Alzheimer’s disease, act antagonistically to maintain an optimal activity of potential oncogene Abl in Drosophila memory center axonal growth. The fly memory center is a bilaterally symmetric pair of brain structures called Mushroom Bodies (MB). This image shows multi-color MB neurons where the α/β neurons are blue.

Image credit: Claire Marquilly and Ana Boulanger

Topic Pages

Read the full Collection of Topic Pages published in PLOS Genetics.

Collection

01/21/2021

Research Article

Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways

Tang et al. investigate the molecular mechanisms underlying bone loss in osteoporosis and other degenerative bone diseases. They find that Runx1 maintains adult bone homeostasis from bone loss though up-regulating Bmp7/Alk3/Smad1/5/8/Runx2/ATF4 and WNT/β-Catenin signaling pathways, which points to a potential new therapeutic target.

Image credit: Tang et al., pgen.1009233

Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways

Recently Published Articles

Current Issue

Current Issue February 2021

01/21/2021

Research Article

Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus

Grau-Bové and colleagues explore the genetic basis of malaria mosquito resistance to pirimiphos-methyl insecticides. Their evolutionary analyses demonstrate that causal mutations in the acetylcholinesterase enzyme emerged in A. gambiae and transferred into A. coluzzii by inter-specific hybridization.

Image credit: James D. Gathany, via Wikimedia Commons

Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus

01/19/2021

Research Article

Estimating FST and kinship for arbitrary population structures

Ochoa and Storey show that measures of relatedness and population structure can be severely biased due to assumptions of of independence that aren't often true of real datasets. They present a new estimation framework for kinship and FST that is practically unbiased for any population structure, and available as open-source R packages.

Estimating FST and kinship for arbitrary population structures

Image credit: Ochoa and Storey, pgen.1009241

01/19/2021

Research Article

Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans

Priest et al. find that the hybrids of two pathogenic fungi are more likely to be viable when the mismatch repair component Msh2, involved in blocking genetic recombination between divergent DNA during meiosis, is lacking in both parents. Uniquely, hybrid progeny did not show increased meiotic recombination.

Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans

Image credit: Priest et al., pgen.1008871

01/07/2021

Perspective

Activation of a bacterial killing machine

Alcock and Palmer discuss phage-induced expression of the bacterial T7SS locus in the context of a new study by Chatterjee et al. (pgen.1009204).

Activation of a bacterial killing machine

Image credit: Chatterjee et al., pgen.1009204

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