02/13/2019
Research Article
A systematic genetic screen identifies essential factors involved in nuclear size control
Here, Cantwell and Nurse exploit the genetic tractability of fission yeast to carry out a systematic genetic screen of deleted essential genes to identify those with aberrant nuclear size phenotypes. The authors reveal 25 novel genes that influence nuclear size, and bioinformatic analysis implicates both RNA processing and protein complexes in connecting nuclear chromatin to the cytoskeleton in nuclear size control.
Image credit: Cantwell and Nurse
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