01/13/2020
Research Article
Using mouse genetic tools, Le, He et al demonstrate that selective deletion of androgen receptor in mesenchymal Gli1-expressing cells abolishes early development of prostate tissue and normal prostate formation, and diminishes prostate pubertal growth and regeneration.
Image credit: Vien Le, Yongfeng He and colleagues
Current Issue January 2020
01/15/2020
Research Article
RNA-binding protein FXR1 is overexpressed in multiple cancers and has previously been shown to be an oncogene in head and neck and lung squamous cell carcinoma. Here, Majumder and Palanisamy show that FXR1 stabilizes miR301a-3p, which in turn targets tumor suppressor p21 and blocks its expression in oral cancer cells.
Image credit: Majumder and Palanisamy
12/27/2019
Research Article
A subset of human lncRNAs have been proposed to represent a new class of cancer causing genes. Here, Elizabeth A. Coe et al identify a set of 245 candidate melanoma-associated lncRNAs that are targeted by the MITF and SOX10 melanoma transcription factors. The authors show that DIRC3 may be a clinically important MITF-SOX10 regulated melanoma tumour suppressor that acts to block the spread of the disease.
Image credit: Elizabeth A. Coe and colleagues
01/09/2020
Research Article
Nurnberg, Guerraty et al identify computationally and then validate experimentally an association between the coronary artery disease risk locus rs2107595 and the gene TWIST1.
Image credit: Nurnberg, Guerraty and colleagues
01/02/2020
Research Article
In this study, Martin A. White et al perturb the E. coli cell cycle by elevating the frequency of DNA double-strand breaks to determine which parameters of the cell cycle are conserved and which are changed. The authors find that this perturbation does not alter average cell size at initiation of DNA replication or initiation of cell division.
Image credit: Martin A. White and colleagues
12/20/2019
Research Article
Fustier, Martínez-Ainsworth and colleagues use a reverse ecology approach to mine the determinants of local adaptation of teosinte populations distributed along two steep altitudinal gradients in Mexico. Their evaluation points to adaptation via an altitudinal multivariate syndrome, in spite of gene flow.
Image credit: Fustier, Martínez-Ainsworth and colleagues
12/12/2019
Topic Page
Verma, Qian and Adhya describe how genomic DNA, RNA and proteins are organised to make up the E. coli nucleiod. This piece is also available as a living document on Wikipedia.
Image credit: Subhash C. Verma and colleagues
11/27/2019
Topic Page
In this Topic Page, Runemark, Vallejo-Marin and Meier review the evolutionary outcomes of interspecific hybridization and the properties of genomes of hybrid genomes, with a focus on interspecific hybridization
Image credit: Anna Runemark and colleagues
11/26/2019
Opinion Piece
Ideker and Flint suggest networks reported to be responsible for psychiatric disease may turn out to be 'hairballs of questionable value', arguing that better network and pathway datasets for complex disorders are needed before robust functional interpretations of GWAS findings can be obtained.
Image credit: Monicore, Pixabay
11/14/2019
Review
In this review, Lilue et al discuss what is known about the most highly variable regions of the mouse genome, why they are important for human disease modelling, and what is known about their ancestral origins.
Image credit: Jingtao Lilue and colleagues
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A new addition to PLOS Topic Pages Collection. Read Maria E. Sousa and Michael H. Farkas published PLOS Genetics Topic Page on Micropeptides.
PLOS launches a new platform that lets research communities drive content priorities. Read the blog announcement here.
Sylvain Alem and colleagues investigate the social learning of string-pulling in the bumblebee which is illustrated through a number of videos.
This PLOS Medicine Special Collection reviews metrics to understand progress in diverse HIV epidemics
2019 PLOS Genetics Research Prize Winner: Fruit fly school – language and dialects for communicating a threat.
Read the announcement here.
Congratulations to PLOS Genetics Associate Editors Harmit Malik and Cédric Feschotte for being elected Fellows of the American Association for the Advancement of Science!
Read Topic Pages Editor Thomas Shafee's article discussing how PLOS and others are building bridges between Wikipedia and the broader knowledge ecosystem.
Congratulations to PLOS Genetics Editorial Board members Harmit Malik and Nadia Singh, who are SMBE President-elect and Secretary-elect respectively!
Congratulations to newly-elected PLOS Genetics Editorial Board Members Sue Jinks-Robertson and Harmit Malik!
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