September 18, 2018
Image credit: Jessica E. Spiewak and colleagues
09/17/2018
Research article
Dorn et al investigate the role of zinc-finger domains
(ZFDs), a component of Topoisomerase 3α. They find ZFD T1 is required for targeting the topoisomerase activity to Holliday junction-like recombination intermediates to enable their processing.
Image credit: Annika Dorn and colleagues
Current Issue August 2018
09/17/2018
REsearch article
CHIP is a multi-functional protein that bridges two opposing cellular processes: protein refolding and protein degradation. Shi, Rubel et al establish a new framework to better understand diseases involving the loss of CHIP function, the spectrum of disease-causing mutations, and the affected pathways.
Image credit: Chang-he Shi, Carrie Rubel and colleagues
09/17/2018
RESEARCH ARTICLE
Molina, Quirin et al find that in the Mediterranean sea urchin, the spatial restriction of nodal on the ventral side of the embryo requires the inhibitory activity of a transcriptional repressor named Yan/Tel.
Image credit: M. Dolores Molina, Magali Quirin and colleagues
09/13/2018
research article
A detailed understanding of how flexibility and constraint shape bacterial two-component signaling systems is emerging, but how new signal transduction architectures arise remains unclear. Here, Davidson et al investigate pathway remodeling using the Firmicute sporulation initiation (Spo0) pathway as a model.
Image credit: Philip Davidson and colleagues
09/10/2018
research article
In this study, Van Den Brink et al examine the consequences of removal or enforced Lipid Droplet (LD) accumulation on the health of retinal cells in flies and mice, and find that overexpression of the fatty acid transport protein (FATP) in retinal pigment cells induces accumulation of LDs in both transgenic flies and mice.
Image credit: Daan M. Van Den Brink and colleagues
09/12/2018
research article
New gene editing tools precisely break DNA at pre-defined genomic locations, but cells repair these lesions using diverse pathways, leading to unpredictable outcomes. Here, Ata et al report on overcoming this obstacle by selectively directing DNA repair of double-stranded breaks through a less well known pathway termed Microhomology-mediated End Joining (MMEJ).
Image credit: Hirotaka Ata and colleagues
09/13/2018
review
Bram Henneman and colleagues discuss the many possibilities of archaeal histone involvement in transcription regulation.
Image credit: Bram Henneman and coleagues
08/23/2018
perspective
Christian E. Rocheleau comments on work from Haley et al, who show that RAB-35 defines a third pathway that functions throughout apoptotic cell clearance in order to make it more robust.
Image credit: Christian E. Rocheleau
08/30/2018
review
Corinne Grey and colleagues discuss the current knowledge about the molecular features of PRDM9 as a DNA-binding protein and epigenetic modifier and how those features contribute to drive double strand break formation.
Image credit: Corine Grey and colleagues
08/16/2018
review
Madeline Weiss and colleagues review different approaches to trace the last universal common ancestor (LUCA).
Image credit: Madeline C. Weiss and colleagues
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