June 17, 2020
Image credit: ivabalk, Pixabay, CC0
05/26/2020
Research Article
In this study, Natri, Bobowik et al examine gene expression and DNA methylation in 116 individuals across Indonesia, and find that up to 10% of genes show differences in expression and methylation patterns between islands, with many involved in immune function.
Image credit: Natri, Bobowik and colleagues
Current Issue June 2020
05/28/2020
Research Article
Osteocalcin (Ocn) is the most abundant non-collagenous protein in bone. Here, Moriishi et al generate Ocn-deficient mice and show that Ocn is not required for bone formation, but is required for optimal bone quality and strength. The authors further find normal glucose metabolism, testosterone synthesis and muscle mass in Ocn-deficient mice.
Image credit: Takeshi Moriishi and colleagues
05/28/2020
Research Article
Diegel et al investigate the nonskeletal effects of osteocalcin (Ocn) by generating a new strain of Ocn knockout mice. The authors find the Ocn-deficient mice they created do not significantly differ from wild-type mice for three examined phenotypes: bone strength, blood glucose and male fertility.
Image credit: Cassandra R. Diegel and colleagues
05/08/2020
Research Article
Jinghu Gao, Linyue Zhao et al identify SID-3 as a new interactor of EHBP-1, a protein that functions with RAB-10 to generate and maintain recycling endosomal tubules. The authors find that SID-3 functions downstream of EHBP-1 to encourage membrane scission, and that ectopic expression of DYN-1 improves recycling transport in SID-3-depleted cells.
Image credit: Gao, Zhao and colleagues
05/07/2020
Research Article
In this study, Eva L. Koch and Frédéric Guillaume combine measurements of offspring number with gene expression data to study responses of the model organism T. castaneum to single and joint effects of drought and heat.
Image credit: GLady, Pixabay, CC0
05/07/2020
Research Article
Using the model eukaryote S. cerevisiae, Porcella et al modulate cellular levels of Pol α and interrogate the impact of this perturbation on replication initiation on DNA synthesis and cellular viability.
Image credit: Sarina Y. Porcella and colleagues
04/23/2020
Review
Courtney Hanna describes novel approaches regulating imprinted genes, those that are expressed from only one copy, depending on which parent they were inherited from, in mouse models.
Image credit: Courtney W. Hanna
04/23/2020
Review
Ding, Huang and Wang discuss current understanding of the molecular mechanisms underlying the reactivation of quiescent neural stem cells.
Image credit: Ding, Huang and Wang
04/20/2020
Review
Naomi Penfold and Jessica Polka provide an overview of current challenges facing preprints, both technical and social, and a vision for their future development.
Image credit: @PLOS, Twitter
04/16/2020
Review
Max J. van Essen, Samuel Nayler and colleagues describe new discoveries of developmental mechanisms that generate cerebellar neural diversity, using single-cell sequencing in mouse and parallel human studies.
Image credit: van Essen, Nayler and colleagues
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A new addition to PLOS Topic Pages Collection. Read Maria E. Sousa and Michael H. Farkas published PLOS Genetics Topic Page on Micropeptides.
PLOS launches a new platform that lets research communities drive content priorities. Read the blog announcement here.
Sylvain Alem and colleagues investigate the social learning of string-pulling in the bumblebee which is illustrated through a number of videos.
This PLOS Medicine Special Collection reviews metrics to understand progress in diverse HIV epidemics
Congratulations to PLOS Genetics Associate Editor Lorraine Symington for being elected a member of the National Academy of Sciences!
Congratulations to PLOS Genetics Associate Editors Harmit Malik and Cédric Feschotte for being elected Fellows of the American Association for the Advancement of Science!
Read Topic Pages Editor Thomas Shafee's article discussing how PLOS and others are building bridges between Wikipedia and the broader knowledge ecosystem.
Congratulations to PLOS Genetics Editorial Board members Harmit Malik and Nadia Singh, who are SMBE President-elect and Secretary-elect respectively!
Congratulations to newly-elected PLOS Genetics Editorial Board Members Sue Jinks-Robertson and Harmit Malik!
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