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Topic Pages

Read the full Collection of Topic Pages published in PLOS Genetics.

Collection

03/08/2021

Research Article

A neuroendocrine pathway modulating osmotic stress in Drosophila

Zandawala et al. investigate the neural mechanisms that are responsible for coordinating responses to counter environmental stresses. They find that the neuropeptide Corazonin (Crz) acts to restore metabolic homeostasis at starvation and osmotic homeostasis during desiccation by inhibiting release of the diuretic hormone CAPA.

Image credit: Zandawala et al., pgen.1009425

A neuroendocrine pathway modulating osmotic stress in Drosophila

Recently Published Articles

Current Issue

Current Issue April 2021

03/09/2021

Research Article

Changes in both trans- and cis-regulatory elements mediate insecticide resistance in a lepidopteron pest, Spodoptera exigua

Hu et al. study the beet armyworm and identify the P450 gene CYP321A8 as the major contributor to resistance to organophosphate and pyrethroid insecticides. They show that two independent mechanisms, overexpression of transcription factors and mutations in the promoter region, are involved in overexpression of CYP321A8.

Image credit: pbio.0020250

Changes in both trans- and cis-regulatory elements mediate insecticide resistance in a lepidopteron pest, Spodoptera exigua

03/09/2021

Research Article

AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis

Sánchez-Vázquez et al. create knock-in human cell lines carrying mutant variants of the telomeric protein TRF1 unable to be modified by AKT, and show that telomere function and telomere length are regulated by extracellular signals upstream of PI3K/AKT activation.

Image credit: Sánchez-Vázquez et al., pgen.1009410

AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis

03/04/2021

Research Article

Stability of the cytosine methylome during post-testicular sperm maturation in mouse

Galan et al. study genome-wide cytosine methylation at seven stages of sperm development in the testis and epididymis. They find stable methylation patterns throughout, supporting the classical view of mammalian cytosine methylation dynamics. They also identify a transient period during which sperm are associated with extracellular DNA.

Stability of the cytosine methylome during post-testicular sperm maturation in mouse

Image credit: Galan et al., pgen.1009416

04/22/2021

Perspective

Putting the brakes on centromere drive in Mimulus

Chang and Malik highlight a new study (pgen.1009418) showing an active co-evolutionary arms race between DNA and protein components of the meiotic machinery in Mimulus, with consequences for individual fitness and molecular divergence.

Putting the brakes on centromere drive in Mimulus

Image credit: Finseth et al., pgen.1009418

03/11/2021

Review

Human genetic admixture

Korunes and Goldberg discuss recent progress in human genetic admixture studies and potential areas for future work. The Review serves as an introduction to the PLOS Genetics Human Genetic Admixture Collection.

Human genetic admixture

Image credit: Mehrjoo et al., pgen.1008385

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