January 15, 2019

The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation

Image credit: Skouloudaki, Papadopoulos and colleagues

Topic Pages Collection

This collection aims to increase the coverage of computational biology and genetics-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed version of the living document on Wikipedia.

Collection

01/17/2019

Research Article

The telomere bouquet is a hub where meiotic double-strand breaks, synapsis, and stable homolog juxtaposition are coordinated in the zebrafish, Danio rerio

In this study, Yana P. Blokhina and colleagues use zebrafish to show that the telomere bouquet is the site where key events leading to homologous chromosome pairing are coordinated. The authors further show that deletion of spo11 results in sterile males, while females produce deformed progeny.

Image credit: Blokhina and colleagues

The telomere bouquet is a hub where meiotic double-strand breaks, synapsis, and stable homolog juxtaposition are coordinated in the zebrafish, Danio rerio

Recently Published Articles

See all articles

Current Issue December 2018

01/14/2019

Research Article

Diapause induces functional axonal regeneration after necrotic insult in C. elegans

Diapause entry and hibernation have the striking ability to protect the nervous system from diverse types of damage. Here, Mauricio Caneo and colleagues show that the diapausing dauer larvae of C. elegans regenerate broken mechanosensory neurons that were damaged by the hyperactivation of degenerins (MEC-4d) or by axotomy during diapause.

Image credit: Caneo and colleagues

Diapause induces functional axonal regeneration after necrotic insult in C. elegans

01/14/2019

Research Article

Estimating recent migration and population-size surfaces

Hussein Al-Asadi and colleagues introduce a novel statistical method - Migration And Population-size Surfaces (MAPS) - to infer migration rates and population sizes across space in recent time periods. The authors apply MAPS to a dataset of contemporary European individuals and provide an integrated analysis of recent population structure and growth over the last ∼3,000 years in Europe.

Image credit: Al-Asadi and colleagues

Estimating recent migration and population-size surfaces

01/07/2019

Research Article

BRASSINOSTEROID-SIGNALING KINASE 3, a plasma membrane-associated scaffold protein involved in early brassinosteroid signaling

In this study, Ren et al investigate the function of BRASSINOSTEROID-SIGNALING KINASE 3 (BSK3) in BR signaling and plant growth and development. The authors find evidence for BSK3 functioning as a scaffold protein and describe new layers of regulation in BR signaling.

Image credit: Hong Ren and colleagues

01/07/2019

Research Article

Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster

Here, Lake et al explore double-strand break (DSB) formation in Drosophila and identify two genes, narya and nenya, that are essential in DSB formation. They go on to find that narya plays a role in processing DSBs into crossovers.

Image credit: Cathleen M. Lake and colleagues

01/09/2019

Research Article

Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting

Here, Symmons et al adapt a microscopy technique, called allele-specific single molecule RNA FISH, to label RNA depending on its origin and find that measurements using this technique recapitulate previously observed RNA imbalances.

Image credit: Orsolya Symmons and colleagues

01/17/2019

Viewpoints

An interaction-based model for neuropsychiatric features of copy-number variants

Jensen and Girirajan propose that candidate genes within neuropsychiatric phenotype copy-number variant regions likely interact with each other through shared pathways to modulate individual gene phenotypes.

Image credit: Jensen and Girirajan

01/17/2019

Perspective

It starts at the ends: The zebrafish meiotic bouquet is where it all begins

Kelle R. Siegfried explores work by Blokhina et al who use a zebrafish model to show that the telomere bouquet is the site where key events leading to homologous chromosome pairing are coordinated.

Image credit: Kelle R. Siegried

01/17/2019

Viewpoints

Wagging the long tail of drivers of prostate cancer

Here, Cannataro and Townsend discuss the utility of uniformly analyzing data sets from a large number of clinically diverse tumors from the same tissue in prostate cancer.

Image credit: Cannataro and Townsend

12/26/2018

Viewpoints

BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2

Here, Cline, Liao, Parons, Paten et al comment on the BRCA Challenge – a data-sharing project initiated to aggregate BRCA1 and BRCA2 data to support collaborative research activities.

Image credit: Cline, Liao, Parsons, Paten and colleagues

Across PLOS

PLOS Ebola Channel

This new channel provides a centralised hub for the latest research and updates on the 2018 Ebola virus outbreak in the Democratic Republic of Congo.
PLOS Topic Pages Collection

A new addition to PLOS Topic Pages Collection. Read Rohan Lowe and colleagues' recently published PLOS Computational Biology Topic Page on transcriptomics technologies.
Channel Your Community’s Research

PLOS launches a new platform that lets research communities drive content priorities. Read the blog announcement here.
PLOS Biology

Sylvain Alem and colleagues investigate the social learning of string-pulling in the bumblebee which is illustrated through a number of videos.
PLOS Medicine

A new collection bringing together PLOS Medicine articles that focus on the prevention of diabetes.

What's happening at PLOS Genetics?

Wikipedia-integrated publishing: a comparison of successful models

Read Topic Pages Editor Thomas Shafee's article discussing how PLOS and others are building bridges between Wikipedia and the broader knowledge ecosystem.
PLOS Genetics Research Prize 2018

In the winning research article, Timothy J. Mullen and Sarah M. Wignall explore the interplay between microtubule bundling and sorting factors during C. elegans oocyte meiosis.
New Collection: Up For A Challenge (U4C) – Stimulating Innovation in Breast Cancer Genetic Epidemiology

Discover our new Collection, which shows the benefits of making larger data sets available to research communities.
US National Academy of Sciences elects new members

Congratulations to newly-elected PLOS Genetics Editorial Board Members Uptal Banerjee and Claude Desplan!

Publish with PLOS

Tweets by @plosgenetics

PLOS Biologue

See All Blogs

Thank you! You have successfully subscribed to the PLOS Genetics newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

Try again

Topic Pages Collection

This collection aims to increase the coverage of computational biology and genetics-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed version of the living document on Wikipedia.

Recently Published Articles

Publish with PLOS

Connect with Us

Get new content from PLOS Genetics in your inbox

Thank you! You have successfully subscribed to the PLOS Genetics newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.