February 23, 2021
Image credit: Pedro M. Araújo
03/08/2021
Research Article
Zandawala et al. investigate the neural mechanisms that are responsible for coordinating responses to counter environmental stresses. They find that the neuropeptide Corazonin (Crz) acts to restore metabolic homeostasis at starvation and osmotic homeostasis during desiccation by inhibiting release of the diuretic hormone CAPA.
Image credit: Zandawala et al., pgen.1009425
Current Issue April 2021
03/09/2021
Research Article
Hu et al. study the beet armyworm and identify the P450 gene CYP321A8 as the major contributor to resistance to organophosphate and pyrethroid insecticides. They show that two independent mechanisms, overexpression of transcription factors and mutations in the promoter region, are involved in overexpression of CYP321A8.
Image credit: pbio.0020250
03/09/2021
Research Article
Sánchez-Vázquez et al. create knock-in human cell lines carrying mutant variants of the telomeric protein TRF1 unable to be modified by AKT, and show that telomere function and telomere length are regulated by extracellular signals upstream of PI3K/AKT activation.
Image credit: Sánchez-Vázquez et al., pgen.1009410
03/08/2021
Research Article
Wang et al. show that HSV-1 infection alters mRNA 3’ end formation and promotes the formation of truncated mRNAs, with ICP27 and other viral factors contributing to these changes. These results suggest that viral infections and cellular stress elicit similar responses in mammalian cells.
Image credit: José R Valverde, Pixabay
03/04/2021
Research Article
Galan et al. study genome-wide cytosine methylation at seven stages of sperm development in the testis and epididymis. They find stable methylation patterns throughout, supporting the classical view of mammalian cytosine methylation dynamics. They also identify a transient period during which sperm are associated with extracellular DNA.
Image credit: Galan et al., pgen.1009416
03/05/2021
Research Article
Sánchez-Ramírez et al. analyze gene expression from Caenorhabditis roundworms and find widespread rewiring of gene regulation. They further show fragility of male genetic networks and sex differences in regulatory evolution of local versus distant elements.
Image credit: Sánchez-Ramírez et al., pgen.1009409
04/22/2021
Viewpoints
Nielsen et al. comment on two recent studies that have taken advantage of MAVE technology to investigate loss-of-function variants in MSH2, which cause the cancer-predisposing Lynch Syndrome.
Image credit: Nielsen et al., pgen.1009496
04/22/2021
Perspective
Chang and Malik highlight a new study (pgen.1009418) showing an active co-evolutionary arms race between DNA and protein components of the meiotic machinery in Mimulus, with consequences for individual fitness and molecular divergence.
Image credit: Finseth et al., pgen.1009418
03/11/2021
Review
Korunes and Goldberg discuss recent progress in human genetic admixture studies and potential areas for future work. The Review serves as an introduction to the PLOS Genetics Human Genetic Admixture Collection.
Image credit: Mehrjoo et al., pgen.1008385
02/25/2021
Perspective
Guery and Claessens highlight a new paper (pgen.1009269) that explores the evolution of specific DNA sequences of the major VSA gene of the human malaria parasite.
Image credit: Tonkin-Hill et al.
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