The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis
King et al. find that a subfamily of Wiskott-Aldrich Syndrome Proteins consisting of JMY and WHAMM is critical for a rapid pathway for cell death. Specifically, JMY-mediated actin assembly in the cytoplasm is necessary for its pro-apoptotic function.
Image credit: Virginia L. King