February 11, 2021

CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon

Image credit: Chen et al., pgen.1009360

Topic Pages

Read the full Collection of Topic Pages published in PLOS Genetics.

Collection

02/12/2021

Research Article

The developmental genetic architecture of vocabulary skills during the first three years of life: Capturing emerging associations with later-life reading and cognition

Verhoef et al. find that the genetic foundations of mid-childhood reading and cognitive abilities involve at least two independent genetic factors that emerge at different developmental stages during early language development and may implicate differences in cognitive processes that are already detectable during toddlerhood.

Image credit: Gerd Altmann, Pixabay

The developmental genetic architecture of vocabulary skills during the first three years of life: Capturing emerging associations with later-life reading and cognition

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Current Issue March 2021

02/16/2021

Research Article

Genomic rearrangements generate hypervariable mini-chromosomes in host-specific isolates of the blast fungus

Langner et al. study supernumerary mini-chromosomes in the blast fungus Magnaporthe oryzae, a pathogen that causes destructive plant diseases. They find mini-chromosomes are rich in repetitive genetic elements and have lower gene densities than core-chromosomes, and suggest that these mini-chromosomes contribute to genome rearrangements and possibly adaptive evolution of the blast fungus.

Image credit: Langner et al., pgen.1009386

Genomic rearrangements generate hypervariable mini-chromosomes in host-specific isolates of the blast fungus

02/16/2021

Research Article

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells

Parkhitko and colleagues screen for synthetic lethal interactions with the Drosophila RB1 tumor suppressor gene ortholog and demonstrate that drugs targeting the identified targets can selectively kill human RB1-deficient cancer cells. They further confirm that these interactions are preserved in the presence of additional strong oncogenic alterations.

Image credit: Parkhitko et al., pgen.1009354

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells

02/11/2021

Research Article

Hybrid seed incompatibility in Capsella is connected to chromatin condensation defects in the endosperm

Dziasek et al. find that the endosperm of interspecific hybrids between closely related species C. rubella and C. grandiflora suffers from mitotic abnormalities and random chromosome loss, likely due to reduced levels of DNA methylation and chromatin condensation.

Image credit: Myriams-Fotos, Pixabay

02/09/2021

Research Article

Vestigial mediates the effect of insulin signaling pathway on wing-morph switching in planthoppers

Zhang et al. find that wing-patterning gene vestigial is key to the development of alternative wing morphs in the brown planthopper. It is selectively and temporally expressed during the wing-morph decision stage, and silencing the gene redirects growth from the long-winged morph to an intermediate wing size.

Image credit: Hai-Jun Xu

02/08/2021

Research Article

Homeodomain protein Six4 prevents the generation of supernumerary Drosophila type II neuroblasts and premature differentiation of intermediate neural progenitors

Chen et al. describe how Six4 functionally and physically interacts with other factors that are involved in regulating INP cell fate specification, which has implications for understanding how complex brains are generated during normal development.

Image credit: Chen et al., pgen.1009371

03/11/2021

Review

Human genetic admixture

Korunes and Goldberg discuss recent progress in human genetic admixture studies and potential areas for future work. The Review serves as an introduction to the PLOS Genetics Human Genetic Admixture Collection.

Image credit: Mehrjoo et al., pgen.1008385

02/25/2021

Perspective

Order within chaos: Harnessing Plasmodium falciparum var gene extreme polymorphism for malaria epidemiology

Guery and Claessens highlight a new paper (pgen.1009269) that explores the evolution of specific DNA sequences of the major VSA gene of the human malaria parasite.

Image credit: Tonkin-Hill et al.

01/14/2021

Viewpoints

The clarifying role of time series data in the population genetics of HIV

Feder, Pennings, and Petrov use time series data to show that drug resistance evolution during ineffective treatment is very fast, providing new evidence that soft sweeps drove early HIV treatment failure.

Image credit: Teyssier Gwenaelle, Pixabay

01/07/2021

Perspective

Harder, better, faster, stronger: Colistin resistance mechanisms in Escherichia coli

Janssen and Schaik comment on a new PLOS Genetics paper (pgen.1009227) which identified six de novo colistin resistance conferring peptides.

Image credit: NIH NIAID, Flickr

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CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon

Topic Pages

Read the full Collection of Topic Pages published in PLOS Genetics.

The developmental genetic architecture of vocabulary skills during the first three years of life: Capturing emerging associations with later-life reading and cognition

Recently Published Articles

Genomic rearrangements generate hypervariable mini-chromosomes in host-specific isolates of the blast fungus

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells

Hybrid seed incompatibility in Capsella is connected to chromatin condensation defects in the endosperm

Vestigial mediates the effect of insulin signaling pathway on wing-morph switching in planthoppers

Homeodomain protein Six4 prevents the generation of supernumerary Drosophila type II neuroblasts and premature differentiation of intermediate neural progenitors

Human genetic admixture

Order within chaos: Harnessing Plasmodium falciparum var gene extreme polymorphism for malaria epidemiology

The clarifying role of time series data in the population genetics of HIV

Harder, better, faster, stronger: Colistin resistance mechanisms in Escherichia coli

Submit your Lab and Study Protocols to PLOS ONE!

COVID-19 Collection

Ten Simple Rules

PLOS Reviewer Center

Human Genetic Admixture Collection

Wendy Bickmore appointed CBE

Kingdom Come

National Academy of Sciences Elects New Members

Publish with PLOS

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Topic Pages

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