August 4, 2022
Image credit: Hiroki Kiyose
07/22/2022
Research Article
Scales et al. investigate the role of Hedgehog signaling in fibroblasts, a central cell type in the pancreatic tumor microenvironment. They find that Gli genes are expressed in pancreatic fibroblasts and that the proteins encoded by these genes impact pancreatic tumor growth and directly control immune cell migration.
Image credit: Michael Scales
Current Issue August 2022
07/25/2022
Research Article
Grice and Liu's in-vivo study is the first to directly rescue the motor defects of a spinal muscular atrophy model by expressing Smn in an identifiable population of Drosophila neuroblasts and developing neurons, highlighting that neuronal sensitivity to SMN loss may arise before synapse establishment and nerve cell maturation.
Image credit: pgen.1010325
07/20/2022
Research Article
Koornneef et al. investigate the localization of the two recombinases RAD51 and DMC1 in wild type and HORMAD1-deficient cells. They contribute to a better understanding of the molecular details of meiotic homologous recombination and the role of HORMAD1 in meiotic prophase.
Image credit: Lieke Koornneef
07/25/2022
Research Article
Losada-Pérez et al. use a D. melanogaster model to search for genetic suppressors of glioblastoma progression. They suggest that both presynaptic and postsynaptic proteins play a role in glioblastoma progression and lethality.
Image credit: pgen.1010329
07/25/2022
Research Article
Du et al. demonstrate the dynamics and importance of phospholipid molecules during embryo development, and provide informative clues to elucidate the regulatory network of embryogenesis.
Image credit: pgen.1010320
07/20/2022
Research Article
Lambing et al. provide mechanistic insights into the control of meiotic DSB formation and reveal diverse functional interactions between SPO11-1, PRD3 and the chromosome axis.
Image credit: pgen.1010298
09/15/2022
Review
Ononye & Downey summarize the type and functions of posttranslational modifications proposed to control Gcn5 in both yeast and human cells.
Image credit: pgen.1010352
07/21/2022
Viewpoints
Rangarajan & Waters explain how Lowry et al. (pgen.1010164) expand our understanding of cyclic di-nucleotide signaling.
Image credit: Lowry et al., pgen.1010164
05/10/2022
Opinion Piece
Gibson offers perspectives on five areas where the robustness of inference can be improved for the bioinformatics of single cell genomics.
Image credit: PublicDomainPictures, Pixabay
02/14/2022
Editorial
The former Natural Variation section at PLOS Genetics relaunches as Human Genetic Variation and Disease. Read the editors' reasoning behind this change.
Image credit: Barsh et al., pgen.1010070
Five new journals unified in addressing global health and environmental challenges are now ready to receive submissions: PLOS Climate, PLOS Sustainability and Transformation, PLOS Water, PLOS Digital Health, and PLOS Global Public Health
The COVID-19 Collection highlights all content published across the PLOS journals relating to the COVID-19 pandemic.
PLOS ONE is now accepting submissions of Lab Protocols, a peer-reviewed article collaboration with protocols.io, and Study Protocols, an article that credits the work done prior to producing and publishing results.
A collection of free training and resources for peer reviewers of PLOS journals—and for the peer review community more broadly—drawn from research and interviews with staff editors, editorial board members, and experienced reviewers.
PLOS Computational Biology's "Ten Simple Rules" articles provide quick, concentrated guides for mastering some of the professional challenges research scientists face in their careers.
PLOS Genetics welcomes several new Associate Editors to our board: Karen Avraham, Anne O'Donnell Luria, Neil Hanchard, Aimee Shen, Jan-Willem Veening, Susana Campino, Nicolas Bierne, Julie Simpson, & Yun Li
Quanjiang Ji (ShanghaiTech University) joined the editorial board and Xiaofeng Zhu (Case Western Reserve University) was promoted as new Section Editors for the PLOS Genetics Methods section.
Congratulations to Associate Editor Michael Lichten and Consulting Editor Nicole King, who are newly elected members of the National Academy of Sciences.
Congratulations to Associate Editor Harmit Malik, who was awarded the Edward Novitski Prize by the Genetics Society of America for his work on genetic conflict. Harmit has also been elected as a new member of the American Academy of Arts & Sciences.
PLOS Genetics announces a new collection on Human Genetic Admixture, introduced by a review from Korunes and Goldberg that discusses recent advances and future directions for the field.
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