Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways
Tang et al. investigate the molecular mechanisms underlying bone loss in osteoporosis and other degenerative bone diseases. They find that Runx1 maintains adult bone homeostasis from bone loss though up-regulating Bmp7/Alk3/Smad1/5/8/Runx2/ATF4 and WNT/β-Catenin signaling pathways, which points to a potential new therapeutic target.
Image credit: Tang et al., pgen.1009233