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Topic Pages

Read the full Collection of Topic Pages published in PLOS Genetics.

Collection

02/12/2021

Research Article

The developmental genetic architecture of vocabulary skills during the first three years of life: Capturing emerging associations with later-life reading and cognition

Verhoef et al. find that the genetic foundations of mid-childhood reading and cognitive abilities involve at least two independent genetic factors that emerge at different developmental stages during early language development and may implicate differences in cognitive processes that are already detectable during toddlerhood.

Image credit: Gerd Altmann, Pixabay

The developmental genetic architecture of vocabulary skills during the first three years of life: Capturing emerging associations with later-life reading and cognition

Recently Published Articles

Current Issue

Current Issue March 2021

02/16/2021

Research Article

Genomic rearrangements generate hypervariable mini-chromosomes in host-specific isolates of the blast fungus

Langner et al. study supernumerary mini-chromosomes in the blast fungus Magnaporthe oryzae, a pathogen that causes destructive plant diseases. They find mini-chromosomes are rich in repetitive genetic elements and have lower gene densities than core-chromosomes, and suggest that these mini-chromosomes contribute to genome rearrangements and possibly adaptive evolution of the blast fungus.

Image credit: Langner et al., pgen.1009386

Genomic rearrangements generate hypervariable mini-chromosomes in host-specific isolates of the blast fungus

02/16/2021

Research Article

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells

Parkhitko and colleagues screen for synthetic lethal interactions with the Drosophila RB1 tumor suppressor gene ortholog and demonstrate that drugs targeting the identified targets can selectively kill human RB1-deficient cancer cells. They further confirm that these interactions are preserved in the presence of additional strong oncogenic alterations.

Image credit: Parkhitko et al., pgen.1009354

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells

03/11/2021

Review

Human genetic admixture

Korunes and Goldberg discuss recent progress in human genetic admixture studies and potential areas for future work. The Review serves as an introduction to the PLOS Genetics Human Genetic Admixture Collection.

Human genetic admixture

Image credit: Mehrjoo et al., pgen.1008385

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