March 5, 2020

The Lid/KDM5 histone demethylase complex activates a critical effector of the oocyte-to-zygote transition

Image credit: Torres-Campana, Kimura et al

Understanding Images

This collection of blog posts and articles showcases the research that created or inspired the journal's monthly issue image, and explains how the image helps us to understand the research question addressed in the manuscript.

COLLECTION

02/18/2020

Research Article

The persimmon genome reveals clues to the evolution of a lineage-specific sex determination system in plants

Here, Akagi et al explore the evolutionary events leading to dioecy, a mating system with separate male and female individuals, in persimmon. The authors discover a lineage-specific whole-genome duplication event and observe that MeGl, a gene previously identified to regulate sex in persimmon, underwent adaptive evolution after this event.

Image credit: Koshy Koshy, Flickr, CC BY

The persimmon genome reveals clues to the evolution of a lineage-specific sex determination system in plants

Recently Published Articles

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Current Issue February 2020

02/20/2020

Research Article

Planarian EGF repeat-containing genes megf6 and hemicentin are required to restrict the stem cell compartment

The freshwater planarian maintains a large population of adult stem cells throughout its lifespan. These cells are constantly dividing and located in a specific spatial compartment, though no known physical boundary keeps them in place. In this study, Lindsay-Mosher et al find that two EGF repeat-containing genes, megf6 and hemicentin, are required to keep stem cells within their compartment.

Image credit: Lindsay-Mosher and colleagues

Planarian EGF repeat-containing genes megf6 and hemicentin are required to restrict the stem cell compartment

02/24/2020

Research Article

Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome

Using mice harboring mutations in the Efnb1 gene in different embryonic tissues, and in receptor genes Ephb1-3, together with quantitative methods to measure craniofacial structures in developing embryos, Niethamer, Teng et al establish the tissue-specific contributions of EPHRIN-B1 mosaicism to craniofacial dysmorphology.

Image credit: Niethamer, Teng and colleagues

Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome

02/18/2020

Research Article

Yeast filamentation signaling is connected to a specific substrate translocation mechanism of the Mep2 transceptor

Ana Sofia Brito et al characterise the signaling role of Saccharomyces cerevisiae Mep2. The authors show that Mep2 variants lacking the C-terminal tail conserve the ability to induce filamentation.

Image credit: Ana Sofia Brito and colleagues

03/05/2020

Research Article

FLS2 is a CDK-like kinase that directly binds IFT70 and is required for proper ciliary disassembly in Chlamydomonas

Using the unicellular green alga, Chlamydomonas, Qin Zhao and colleagues identify a CDK-like kinase, FLS2, that hinders cilia resorption when mutated, leading to delay of cell cycle progression.

Image credit: Qin Zhao and colleagues

02/18/2020

Research Article

Control of clathrin-mediated endocytosis by NIMA family kinases

Here, Joseph, Wang et al show that C. elegans NEKL-2 and NEKL-3 regukate endocytosis. The authors characterise the specific functions of NEKL-2 and NEKL-3 in endocytosis and show that their human counterparts, which have been implicated in cardiovascular and renal diseases as well as many types of cancers, likely have very similar functions.

Image credit: Joseph, Wang and colleagues

03/05/2020

Perspective

The emerging role of transcriptional regulation in the oocyte-to-zygote transition

Navarro-Costa and Martinho discuss research by Torres-Campana, Kimura et al, who identify chromatin remodelers Lid/KMD5 as effectors of the oocyte-to-zygote transition in Drosophila.

Image credit: Navarro-Costa and Martinho

02/13/2020

Review

Magnetic genes: Studying the genetics of biomineralization in magnetotactic bacteria

McCauseland and Komeili highlight magnetotactic bacteria, a group of organisms capable of producing organelles called magnetosomes where crystals of magnetic material are synthesized and housed.

Image credit: McCauseland and Komeili

12/12/2019

Topic Page

Architecture of the Escherichia coli nucleoid

Verma, Qian and Adhya describe how genomic DNA, RNA and proteins are organised to make up the E. coli nucleiod. This piece is also available as a living document on Wikipedia.

Image credit: Subhash C. Verma and colleagues

11/27/2019

Topic Page

Eukaryote hybrid genomes

In this Topic Page, Runemark, Vallejo-Marin and Meier review the evolutionary outcomes of interspecific hybridization and the properties of genomes of hybrid genomes, with a focus on interspecific hybridization

Image credit: Anna Runemark and colleagues

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2019 PLOS Genetics Research Prize Winner: Fruit fly school – language and dialects for communicating a threat.

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This collection of blog posts and articles showcases the research that created or inspired the journal's monthly issue image, and explains how the image helps us to understand the research question addressed in the manuscript.

Recently Published Articles

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