06/16/2025
research article
Here, the authors study the telomeres in Mimulus by investigating the noncoding telomerase RNA (TR), which determines the telomere sequence in eukaryotes. They find that TR duplications and divergence are linked to the evolution of multiple distinct telomere repeat types across species.
Image credit: pgen.1011738
Current Issue June 2025
06/09/2025
research article
In this study, the authors use genotype data to predict environmental characteristics of maize germplasm collections and identify varieties potentially pre-adapted to target environments. They find that environment-of-origin data and genome scans for climate-associated loci offer little benefit for prioritizing accessions, despite evidence of environmental adaptation.
Image credit: pgen.1011714
06/17/2025
research article
In this study, the authors conduct a metabolomic analysis revealing that both total anthocyanin content and the relative abundance of individual anthocyanin species contribute to fruit color variation observed between yellow- and dark red-fruited cultivars, and identify PavMYB.C2 as a key regulator controlling anthocyanin biosynthesis and Cy3G accumulation.
Image credit: pgen.1011761
06/10/2025
research article
In this report, the author describes a novel mathematical framework for quantifying genetic buffering relationships between genes, introducing a new neutrality model that enables gene interactions to be formally defined, compared and classified across systems in a consistent and generalizable way.
Image credit: pgen.1011730
06/16/2025
research article
In this study, the authors report that Set1-mediated cell cycle-dependent methylation of Dam1 contributes to kinetochore assembly and chromosomal stability. Dam1 methylation peaks in metaphase and is regulated by interaction with Set1 and the demethylase Jhd2, influencing chromosome segregation fidelity.
Image credit: pgen.1011760
06/13/2025
research article
In this study, the authors develop a genetic mouse model to trace androgen receptor-expressing cells during prostate development and show that β-catenin deletion in these cells disrupts morphogenesis and activates cell death pathways.
Image credit: pgen.1011756
06/03/2025
research article
In this study, the authors identify HarmGR13 as the gustatory receptor mediating larval responses to myo-inositol and ribose in Helicoverpa armigera, linking it to feeding behavior and sensory neuron activity.
Image credit: pgen.1011744
06/03/2025
research article
Here, the authors investigate how sex chromosome aneuploidy in Drosophila affects traits like female fecundity and male viability, and estimate its frequency and evolutionary consequences in lab populations.
Image credit: pgen.1011703
06/02/2025
research article
Here, the authors examine ciRS-7 across nine adenocarcinomas and find that it is largely absent from cancer cells but present in the tumor microenvironment, regulated by DNA methylation and histone acetylation.
Image credit: pgen.1011726
06/10/2025
research article
Here the authors show that the SAF-A SAP domain and serines S14/S26 are required for XIST localization and proliferation, but not gene expression or splicing.
Image credit: pgen.1011719
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