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Synaptonemal Complex dimerization regulates chromosome alignment and crossover patterning in meiosis

March 17, 2021

Synaptonemal Complex dimerization regulates chromosome alignment and crossover patterning in meiosis

Nuclei in meiotic prophase of a C. elegans gonad; meiosis progresses from left to right. Nuclei are immunostained for markers of genetic exchanges (GFP::COSA-1, green), foci of ongoing DNA repair (RAD-51, red), and the structural backbone of meiotic chromosomes (HTP-3, blue).

Image credit: Spencer Gordon

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Current Issue April 2021

03/22/2021

Research Article

Independent domains for recruitment of PRC1 and PRC2 by human XIST

Dixon-McDougall and Brown study the human long noncoding RNA XIST, and identify the regions of the RNA that are required for chromatin modification and protein recruitment which are somewhat different than for mouse XIST. Independent domains were required for the PRC1 and PRC2 pathways, but all regions tested were important for some aspect of XIST functionality.

Image credit: Dixon-McDougall and Brown, pgen.1009123

Independent domains for recruitment of PRC1 and PRC2 by human XIST

03/19/2021

Research Article

The haplolethality paradox of the wupA gene in Drosophila

Casas-Tintó and Ferrús study the haplolethal region of the Troponin I (TnI) encoding gene wupA in Drosophila and find that haplolethality results from the combined haploinsufficiency of a large set of TnI isoforms. These findings compare to another studiedhaplolethal region and reveal a scenario of strict dosage dependence with implications for gene expression regulation and splitting.

The haplolethality paradox of the wupA gene in Drosophila

Image credit: Casas-Tintó and Ferrús, pgen.1009108

04/22/2021

Perspective

Putting the brakes on centromere drive in Mimulus

Chang and Malik highlight a new study (pgen.1009418) showing an active co-evolutionary arms race between DNA and protein components of the meiotic machinery in Mimulus, with consequences for individual fitness and molecular divergence.

Putting the brakes on centromere drive in Mimulus

Image credit: Finseth et al., pgen.1009418

03/11/2021

Review

Human genetic admixture

Korunes and Goldberg discuss recent progress in human genetic admixture studies and potential areas for future work. The Review serves as an introduction to the PLOS Genetics Human Genetic Admixture Collection.

Human genetic admixture

Image credit: Mehrjoo et al., pgen.1008385

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