September 7, 2022
Image credit: Perinthottathil Sreejith
09/01/2022
Research Article
Paranjpe et al develop a method to identify high genetic risk individuals during the presymptomatic phase of Alzheimer's disease, enabling researchers to discover new protein-based biomarkers in the early stages of disease progression.
Image credit: Robina Weermeijer, Unsplash
Current Issue September 2022
09/08/2022
Research Article
Chan et al. characterize the complex sequence diversity of individual COVID-19 infections. The sequence polymorphism they observe shows that SARS-CoV-2 infections are heterogeneous mixtures. They suggest that minority alleles in earlier SARS-CoV-2 infections may play an important role in the continuing evolution of new variants of concern.
Image credit: CDC Public Health Image Library
09/07/2022
Research Article
Li et al. use data from the California Biobank to show that the risk of a common pediatric brain tumor increases when a Latino child has a higher proportion of European ancestry. This ancestral risk is localized to specific regions of the genome, especially in Chromosome 6 near the SNX14 gene, which is associated with cancer-related growth signaling pathway described by MAPK/ERK.
Image credit: National Cancer Institute, Unsplash
09/12/2022
Research Article
Bi et al. provide new evidence for studies on the molecular mechanisms of F-actin dynamics in root hair formation and in plant abiotic stress tolerance.
Image credit: pgen.1010338
09/08/2022
Research Article
Sun et al. identify ten cell types as well as their differentially expressed genes which are affected by the deficiency of the SMN protein.
Image credit: pgen.1010392
09/01/2022
Research Article
Deliu et al. find that Minute animals have disrupted production of ecdysone, and pinpoint this defect to loss of ribosomal protein function within a subset of neurons that control ecdysone production through the neurotransmitter serotonin.
Image credit: pgen.1010371
09/22/2022
Review
Steiner & Novembre review theoretical models for the spatial spread of adaptive variants and identify areas to be improved in future work.
Image credit: Elena Mozhvilo, Unsplash
09/15/2022
Review
Ononye & Downey summarize the type and functions of posttranslational modifications proposed to control Gcn5 in both yeast and human cells.
Image credit: pgen.1010352
07/21/2022
Viewpoints
Rangarajan & Waters explain how Lowry et al. (pgen.1010164) expand our understanding of cyclic di-nucleotide signaling.
Image credit: Lowry et al., pgen.1010164
05/10/2022
Opinion Piece
Gibson offers perspectives on five areas where the robustness of inference can be improved for the bioinformatics of single cell genomics.
Image credit: PublicDomainPictures, Pixabay
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The COVID-19 Collection highlights all content published across the PLOS journals relating to the COVID-19 pandemic.
PLOS ONE is now accepting submissions of Lab Protocols, a peer-reviewed article collaboration with protocols.io, and Study Protocols, an article that credits the work done prior to producing and publishing results.
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PLOS Computational Biology's "Ten Simple Rules" articles provide quick, concentrated guides for mastering some of the professional challenges research scientists face in their careers.
PLOS Genetics welcomes several new Associate Editors to our board: Karen Avraham, Anne O'Donnell Luria, Neil Hanchard, Aimee Shen, Jan-Willem Veening, Susana Campino, Nicolas Bierne, Julie Simpson, & Yun Li
The former Natural Variation section at PLOS Genetics relaunches as Human Genetic Variation and Disease. Read the editors' reasoning behind this change.
Quanjiang Ji (ShanghaiTech University) joined the editorial board and Xiaofeng Zhu (Case Western Reserve University) was promoted as new Section Editors for the PLOS Genetics Methods section.
Congratulations to Associate Editor Michael Lichten and Consulting Editor Nicole King, who are newly elected members of the National Academy of Sciences.
Congratulations to Associate Editor Harmit Malik, who was awarded the Edward Novitski Prize by the Genetics Society of America for his work on genetic conflict. Harmit has also been elected as a new member of the American Academy of Arts & Sciences.
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