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The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish

January 4, 2019

The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish

Image credit: Uri Manor, NICHD, Flickr, Creative Commons (CC-BY 2.0)

Topic Pages Collection

This collection aims to increase the coverage of computational biology and genetics-related topics                                                  in Wikipedia by rewarding authors with a citable, PubMed-indexed version of the living document on Wikipedia.

Collection

01/07/2019

Research Article

BRASSINOSTEROID-SIGNALING KINASE 3, a plasma membrane-associated scaffold protein involved in early brassinosteroid signaling

Brassinosteroids (BRs) are steroid hormones that regulate numerous processes throughout the plant life cycle. In this study, Ren et al investigate the function of BRASSINOSTEROID-SIGNALING KINASE 3 (BSK3) in BR signaling and plant growth and development. The authors find evidence for BSK3 functioning as a scaffold protein and describe new layers of regulation in BR signaling.

Image credit: Hong Ren and colleagues

BRASSINOSTEROID-SIGNALING KINASE 3, a plasma membrane-associated scaffold protein involved in early brassinosteroid signaling

Recently Published Articles

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Current Issue

Current Issue December 2018

01/07/2019

Research Article

Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster

Here, Cathleen M. Lake and colleagues explore double-strand break (DSB) formation, an essential component of the process of meiotic recombination, in Drosophila. The authors identify two genes, narya and nenya, that are essential in DSB formation. They go on to find that narya plays a role in processing DSBs into crossovers.

Image credit: Cathleen M. Lake and colleagues

Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster

01/09/2019

Research Article

Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting

Parental contributions to the molecules in a given cell are not always equal, however, it remains difficult to measure the parental origin of individual molecules. Here, Symmons et al adapt a microscopy technique, called allele-specific single molecule RNA FISH, to label RNA depending on its origin. The authors find that measurements using this technique recapitulate previously observed RNA imbalances. 

Image credit: Orsolya Symmons and colleagues

Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting

12/26/2018

Research Article

Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling

Here, Nir, Farabella, Estrada, Ebeling et al use super-resolution microscopy methods to trace 8 megabases of human chromosome 19. The authors discover distinct structures that, in spite of considerable variability, can predict whether such regions correspond to active (A-type) or inactive (B-type) compartments.

Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling

Image credit: Nir, Farabella, Estrada, Ebeling and colleagues

12/26/2018

Research Article

Regulation of pollen lipid body biogenesis by MAP kinases and downstream WRKY transcription factors in Arabidopsis

Signaling pathways that control activities in non-photosynthetic plastids, important sites of plant metabolism, are largely unknown. Here, Zheng et al report that GPT1 is a key target of WRKY2/34 transcription factors during pollen development, and describe the role of plastid-localised GPT1 in pollen lipid accumulation.

Regulation of pollen lipid body biogenesis by MAP kinases and downstream WRKY transcription factors in Arabidopsis

Image credit: Zheng and colleagues

12/20/2018

Editorial

Doubling down on forensic twin studies

PLOS Genetics editors discuss research by Krawczak et al, which describes an analytical approach for genetically distinguishing between monozygotic twins, and the ethical considerations that led to the article's publication in its current form.

Doubling down on forensic twin studies

Image credit: Andy Leppard, Flickr

12/13/2018

Topic Page

Micropeptide

Sousa and Farkas discuss micropeptides. Commonly defined as polypeptides of less than 100-150 amino acids in length, micropeptides were once overlooked due to their small size, however, hundreds of thousands have now been identified. This article is also published as a live page on Wikipedia.

Micropeptide

Image credit: Sousa and Farkas

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