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A variably imprinted epiallele impacts seed development

November 5, 2018

A variably imprinted epiallele impacts seed development

Image credit: Pignatta, Novitzky and colleagues

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PLOS Research News

11/07/2018

research article

Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors

Here, Rousset, Cui and colleagues present the use of a library of ~92,000 guide RNAs directing the dCas9 protein to silence, one by one, all the genes in the chromosome of E. coli. The screens highlight previously known and new genetic interactions between phages and their host’s pathways, and emphasize the importance of bacterial capsule in the resistance to multiple phages.

Image credit: Rousset, Cui and colleagues

Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors

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Current Issue

Current Issue October 2018

11/06/2018

research article

Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness

In this study, Aw, Towarnicki et al present a series of studies designed to experimentally test the interaction between diet and mitotype in Drosophila, and provide a mechanism by which selection occurs. The authors produce data which leads to the questioning of the use of mtDNA as an assumed neutral marker in evolutionary and population genetic studies.

Image credit: Aw, Towarnicki and colleagues

Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness

11/06/2018

research article

Functional equivalence of germ plasm organizers

Pritesh Krishnakumar, Stephen Riemer and colleagues show that the two germ plasm organizers, Oskar (Osk) from Drosophila and Bucky ball (Buc) from zebrafish, show similar activities during germ cell specification through the use of a cross species approach. The study data may provide the first example of two proteins with the same biological role, but distinct sequences.

Image credit: Krishnakumar, Riemer and colleagues

Functional equivalence of germ plasm organizers

11/01/2018

RESEARCH ARTICLE

Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster

Dietary restriction (DR) is a robust environmental method to slow aging and age-related diseases in diverse organisms. In Drosophila, DR is able to slow the age-related decline in gut integrity. Kazutaka Akagi and colleagues identify that an intrinsic mechanism regulates gut barrier function through regulation of enterocyte apoptosis by ‘cell competition’.

Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster

Image credit: Kazutaka Akagi and colleagues

10/31/2018

RESEARCH ARTICLE

C. elegans ZHP-4 is required at multiple distinct steps in the formation of crossovers and their transition to segregation competent chiasmata

Hanh Nguyen and colleagues investigate the role of ZHP-4, and its partner ZHP-3 which form a complex that associates along paired chromosomes and finally with crossover sites. Their results suggest that ZHP-3/4 work at early and late steps in the process to stabilize other factors required for crossover formation.

C. elegans ZHP-4 is required at multiple distinct steps in the formation of crossovers and their transition to segregation competent chiasmata

Image credit: Hanh Nguyen and colleagues

09/13/2018

review

Structure and function of archaeal histones

Bram Henneman and colleagues discuss the many possibilities of archaeal histone involvement in transcription regulation.

Structure and function of archaeal histones

Image credit: Bram Henneman and coleagues

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