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Current Issue June 2021

05/20/2021

Research Article

CENP-C functions in centromere assembly, the maintenance of CENP-A asymmetry and epigenetic age in Drosophila germline stem cells

Carty et al. study the role of the centromere component CENP-C in controlling germline stem cell divisions in the Drosophila ovary. They find that CENP-C is critical for correct centromere assembly, and its depletion in germline stem cells disrupts the balance of stem and daughter cells in the developing ovary, impacting cell fate.

Image credit: Carty et al., pgen.1009247

CENP-C functions in centromere assembly, the maintenance of CENP-A asymmetry and epigenetic age in Drosophila germline stem cells

05/18/2021

Research Article

RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis

Sanchez-Rebato et al. show that the chromatin-remodeling protein RAD54 is required for the repair of meiotic double strand breaks by RAD51 in the plant Arabidopsis thaliana, and that this function is downstream of the meiotic role of RAD51 in supporting the activity of DMC1.

RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis

Image credit: Sanchez-Rebato et al., pgen.1008919

05/20/2021

Research Article

Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways

He et al. discover that suppression of the transcription factor LET-607/CREBH, a regulator of cellular defense and proteostatic responses, triggers adaptive induction of DAF-16-dependent stress responses in C. elegans. This suppression improves stress resistance and extends C. elegans lifespan in a DAF-16-dependent manner.

Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways

Image credit: He et al., pgen.1009573

05/20/2021

Review

Gene action, genetic variation, and GWAS: A user-friendly web tool

Hivert et al. present the Falconer ShinyApp, a user-friendly web tool that shows how the combination of gene action and allele frequencies at causal loci translate to genetic variance and genetic variance components for a complex trait.

Gene action, genetic variation, and GWAS: A user-friendly web tool

Image credit: Darwin Laganzon, Pixabay

04/22/2021

Perspective

Putting the brakes on centromere drive in Mimulus

Chang and Malik highlight a new study (pgen.1009418) showing an active co-evolutionary arms race between DNA and protein components of the meiotic machinery in Mimulus, with consequences for individual fitness and molecular divergence.

Putting the brakes on centromere drive in Mimulus

Image credit: Finseth et al., pgen.1009418

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