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Mutations in ARL2BP, a protein required for ciliary microtubule structure, cause syndromic male infertility in humans and mice

August 19, 2019

Mutations in ARL2BP, a protein required for ciliary microtubule structure, cause syndromic male infertility in humans and mice

Image credit: Moye, Bedoni and colleagues

Understanding Images

This collection of blog posts and articles showcases the research that created or inspired the journal's monthly                                                  issue image, and explains how the image helps us to understand the research question addressed in the manuscript.

COLLECTION

08/19/2019

Research Article

Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila

Sanchez et al use the developing wing primordium of Drosophila to identify the molecular mechanisms and signaling molecules that mediate communication between adjacent cell populations upon a targeted reduction of growth rate. The authors reveal how different signals can regulate tissue growth and cell proliferation in an independent manner to coordinate the tissue size and cell number of different parts of an organ.

Image credit: Juan A. Sanchez and colleagues

Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila

Recently Published Articles

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Current Issue

Current Issue July 2019

08/22/2019

Research Article

Identification of new components of the RipC-FtsEX cell separation pathway of Corynebacterineae

To enhance understanding of cell surface biogenesis in Corynebacterineae, Lim et al perform a global genetic analysis of gene function in the model system Corynebacterium glutamicum (Cglu) using transposon sequencing. In addition to defining the essential gene set in this organism, the authors also identify SteA and SteB as components of the cytokinetic ring. 

Image credit: Hoong Chuin Lim and colleagues

Identification of new components of the RipC-FtsEX cell separation pathway of Corynebacterineae

08/19/2019

Research Article

An estimator of first coalescent time reveals selection on young variants and large heterogeneity in rare allele ages among human populations

Here, Platt et al develop a method to estimate the time when a copy of a gene most recently shared ancestry with other copies of that gene. The method also provides an estimate of the upper bound of when a mutation has arisen, and can be used to study the ages of alleles that are found in a population.

Image credit: Alexander Platt and colleagues

An estimator of first coalescent time reveals selection on young variants and large heterogeneity in rare allele ages among human populations

08/15/2019

Research Article

A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster

Here, Lang et al identify a regulatory role for the insulin-like signaling cascade affecting uric acid (UA) metabolism using a Drosophila melanogaster model. The authors determine previously unrecognized potential drug targets to treat elevated UA levels and associated pathologies such as gout or UA kidney stones.

A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster

Image credit: Sven Lang and colleagues

08/14/2019

Research Article

Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndrome

The mechanisms required for segmentation of the pharyngeal apparatus to individual arches are not precisely delineated in mammalian species. Using mouse models, Hasten and Morrow find that two transcription factor genes, Tbx1 and Foxi3, genetically interact in the third pharyngeal pouch endoderm during thymus and parathyroid gland development.

Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndrome

Image credit: Erica Hasten and Bernice E. Morrow

06/24/2019

Opinion Piece

Solving the missing heritability problem

In this Opinion Piece, Alexander Young discusses the 'missing heritability problem' - the gap between heritability estimates from genotype and twin data. 

Solving the missing heritability problem

Image credit: Alexander I. Young

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