July 22, 2021

Powerful detection of polygenic selection and evidence of environmental adaptation in US beef cattle

Image credit: Jaclyn Ketchum

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07/21/2021

Research Article

DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence

Fry et al. investigate the role of daf-18, a C. elegans ortholog of a human tumor suppressor, in maintaining primordial germ cell quiescence in L1 starvation. They find that maternal or zygotic daf-18 is sufficient to maintain cell cycle quiescence, that daf-18 acts in the germ line and soma, and that daf-18 affects timing of PGC divisions in fed animals.

Image credit: Amanda L. Fry

DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence

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Current Issue August 2021

07/19/2021

Research Article

A spectral theory for Wright’s inbreeding coefficients and related quantities

François and Gain describe the relationships between Wright’s inbreeding coefficient and principal component analysis for a model of K discrete populations, and provide an equivalent definition of the coefficient based on the decomposition of the genotype matrix into between and within-population matrices.

Image credit: François and Gain

A spectral theory for Wright’s inbreeding coefficients and related quantities

07/15/2021

Review

Tetrahymena meiosis: Simple yet ingenious

Loidl comparises the unconventional meiotic programs of Tetrahymena thermophila to those of higher multicellular organisms, and suggests this may reveal how extant meiosis evolved from proto-meiosis.

Image credit: Josef Loidl

Tetrahymena meiosis: Simple yet ingenious

07/19/2021

Research Article

Highly conserved and cis-acting lncRNAs produced from paralogous regions in the center of HOXA and HOXB clusters in the endoderm lineage

Image credit: Neta Degani and Igor Ulitsky

07/27/2021

Research Article

Ras/ERK and PI3K/AKT signaling differentially regulate oncogenic ERG mediated transcription in prostate cells

Image credit: Strittmatter et al

07/29/2021

Research Article

Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease

Image credit: Audain et al

09/09/2021

Viewpoints

Germline genome modification through novel political, ethical, and social lenses

Xafis et al apply multiple lenses to aspects of human genome germline editing to uncover previously underexplored considerations that are important to reflect on in global discussions.

Image credit: mcmurryjulie, Pixabay

09/09/2021

Viewpoints

Germline genome editing: Moratorium, hard law, or an informed adaptive consensus?

Kaan et al examine the practicality of an international moratorium on human germline genome editing, and advocate for a community engagement approach instead.

Image credit: mcmurryjulie, Pixabay

09/02/2021

Perspective

Rhino breaks the deadlock in Drosophila testis

Molla Herman and Brasset highlight new research by Chen et al (pgen.1009591) on the Rhino-Deadlock-Cutoff complex's essential role in transposon repression in males.

Image credit: Molla Herman and Brasset

07/15/2021

Opinion Piece

Meiosis in Quarantine discussions lead to an action plan to increase diversity and inclusion within the genetics community

Billmyre et al present a DEI plan from a webinar discussion, including recommended actions for conferences, graduate school, and beyond.

Image credit: pgen.1009648

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New Tropical Agriculture Collection

PLOS Genetics releases a new curated collection in partnership with PLOS ONE, celebrating the innovative agricultural research taking place in tropical countries.
National Academy of Sciences elects new members

Congratulations to PLOS Genetics Associate Editors Denise Montell, Anita Hopper, Joe Heitman, and Marisa Bartolomei for being elected members of the National Academy!
American Academy of Arts and Sciences elects new members

Congratulations to PLOS Genetics Associate Editors Sue Jinks-Robertson and Sarah A. Tishkoff for being elected members of the American Academy in the area of biological sciences!
Human Genetic Admixture Collection

PLOS Genetics announces a new collection on Human Genetic Admixture, introduced by a review from Korunes and Goldberg that discusses recent advances and future directions for the field.
Wendy Bickmore appointed CBE

Congratulations to Epigenetics Section Editor Wendy Bickmore for being appointed CBE in recognition of her services to biomedical sciences and to women in science!

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