August 9, 2021
Image credit: Haifeng Zhang
08/09/2021
Research Article
Kanwal et al show that posterior lobe progenitors in the Drosophila lymph gland are maintained by a local signaling center defined by Ubx and Collier in the tertiary lobe. The Ubx domain regulates the homeostasis of the posterior lobe progenitors in normal development and an immune-challenged scenario.
Image credit: Aditya Kanwal
Current Issue September 2021
08/02/2021
Research Article
Christen et al study a hereditary cerebellar ataxia in Belgian Shepherd dogs and find a private homozygous structural variant, a deletion that includes the entire protein coding sequence of SELENOP. Selenium levels in the blood of homozygous mutant puppies were 30% lower, and Selenop-/- knock-out mice developed ataxia but their histopathological changes were less severe than in the investigated dogs.
Image credit: Katrin B., Pixabay
08/03/2021
Research Article
Li et al report a stress-responsive MADS-box transcription factor OsMADS23 from rice conferring osmotic stress tolerance in plants. OsMADS23 activates the transcription of target genes that are key components for ABA and proline biosynthesis, and knockout mutants had lower ABA levels and exhibited higher sensitivity to drought and oxidative stress than wild type.
Image credit: Li et al
08/12/2021
Research Article
Gavory et al study the NUP98-HOXA9 translocation which is associated with acute myeloid leukemia. They find that NA9 promotes cell fate transdetermination and that this phenomenon is greatly influenced by NA9 modifiers involved in epigenetic regulation.
Image credit: Gavory et al
08/12/2021
Research Article
Insolera et al find that that in fission-defective neurons, mitophagy becomes induced, and that the lipid channel containing protein Vps13D has separable functions in mitochondrial fission and phagophore elongation.
Image credit: Ryan Insolera
08/09/2021
Research Article
Charlesworth et al describe evidence that a new Y chromosome evolved recently in the guppy from an X chromosome, replacing the old, degenerated Y, and explaining why the guppy pair still recombine. They suggest that male coloration factors probably arose after the new Y evolved, as they have already evolved expression that is confined to males, a different way to avoid conflict between the sexes.
Image credit: còi photograper lê, Pixabay
09/09/2021
Viewpoints
Xafis et al apply multiple lenses to aspects of human genome germline editing to uncover previously underexplored considerations that are important to reflect on in global discussions.
Image credit: mcmurryjulie, Pixabay
09/09/2021
Viewpoints
Kaan et al examine the practicality of an international moratorium on human germline genome editing, and advocate for a community engagement approach instead.
Image credit: mcmurryjulie, Pixabay
09/02/2021
Perspective
Molla Herman and Brasset highlight new research by Chen et al (pgen.1009591) on the Rhino-Deadlock-Cutoff complex's essential role in transposon repression in males.
Image credit: Molla Herman and Brasset
07/15/2021
Opinion Piece
Billmyre et al present a DEI plan from a webinar discussion, including recommended actions for conferences, graduate school, and beyond.
Image credit: pgen.1009648
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