November 25, 2019
Image credit: Christian Bueltemann, Pixabay
11/11/2019
Research Article
In this study, Yongbo Xue and colleagues identify the role of SUR-8 in circadian locomotor rhythms, and characterize SUR-8 as a scaffold protein to bridge PER and a phosphatase (PP1-87B) together to regulate PER phosphorylation and abundance.
Image credit: Yongbu Xue and colleagues
Current Issue November 2019
11/01/2019
Research Article
Alex Diaz-Papkovich and colleagues use a dimension reduction method—UMAP—to visualize population structure in three genomic datasets and find previously unobserved patterns, revealing fine-scale population structure and illustrating differences between groups in traits such as white blood cell count, height, and FEV1, a measure of lung function.
Image credit: Alex Diaz-Papkovich and colleagues
11/15/2019
Research Article
Here, John Snedeker and colleagues explore the underlying mechanism(s) underlying the variable effects of Ttc21b mutation on brain size by performing a quantitative trait locus (QTL) analysis. The results show two regions of genomic significance that correlate with smaller brain size.
Image credit: John Snedeker and colleagues
11/06/2019
Research Article
Here, Austin Dreyer and colleagues investigate control of feeding behavior by two molecularly-distinct populations of neurons in a putative circadian output center in the fruit fly, Drosophila melanogaster. Their findings have important implications for our understanding of how the central clock coordinately modulates distinct behavioral outputs.
Image credit: Austin P Dreyer and colleagues
11/20/2019
Research Article
Hong Li and colleagues identify novel glycosyltransferases and established the first complete lipopolysaccharide biosynthetic pathway in G27 through systematic mutagenesis of glycosyltransferase genes in the model strain G27 combined with lipopolysaccharide structural analysis.
Image credit: Hon Li and colleagues
11/25/2019
Research Article
In this study, Liangcai Lin and colleagues identify STK-12 to be a crucial factor for cellulase gene downregulation through systematically screening N. crassa serine-threonine protein kinase mutants by determining their cellulase production capacity.
Image credit: Liangcai Lin and colleagues
11/27/2019
Topic Page
In this Topic Page, Runemark, Vallejo-Marin and Meier review the evolutionary outcomes of interspecific hybridization and the properties of genomes of hybrid genomes, with a focus on interspecific hybridization
Image credit: Anna Runemark and colleagues
11/26/2019
Opinion Piece
Ideker and Flint suggest networks reported to be responsible for psychiatric disease may turn out to be 'hairballs of questionable value', arguing that better network and pathway datasets for complex disorders are needed before robust functional interpretations of GWAS findings can be obtained.
Image credit: Monicore, Pixabay
11/14/2019
Review
In this review, Lilue et al discuss what is known about the most highly variable regions of the mouse genome, why they are important for human disease modelling, and what is known about their ancestral origins.
Image credit: Jingtao Lilue and colleagues
11/07/2019
Review
In this review, Miller, Cook and Hawley provide a brief history of balancers in Drosophila, discuss how they are used today, and provide examples of unexpected recombination events involving balancers that can lead to stock breakdown.
Image credit: Danny E Miller and colleagues
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A new addition to PLOS Topic Pages Collection. Read Maria E. Sousa and Michael H. Farkas published PLOS Genetics Topic Page on Micropeptides.
PLOS launches a new platform that lets research communities drive content priorities. Read the blog announcement here.
Sylvain Alem and colleagues investigate the social learning of string-pulling in the bumblebee which is illustrated through a number of videos.
This PLOS Medicine Special Collection reviews metrics to understand progress in diverse HIV epidemics
2019 PLOS Genetics Research Prize Winner: Fruit fly school – language and dialects for communicating a threat.
Read the announcement here.
Congratulations to PLOS Genetics Associate Editors Harmit Malik and Cédric Feschotte for being elected Fellows of the American Association for the Advancement of Science!
Read Topic Pages Editor Thomas Shafee's article discussing how PLOS and others are building bridges between Wikipedia and the broader knowledge ecosystem.
Congratulations to PLOS Genetics Editorial Board members Harmit Malik and Nadia Singh, who are SMBE President-elect and Secretary-elect respectively!
Congratulations to newly-elected PLOS Genetics Editorial Board Members Sue Jinks-Robertson and Harmit Malik!
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