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Understanding Images

This collection of blog posts and articles showcases the research that created or inspired the journal's monthly                                                  issue image, and explains how the image helps us to understand the research question addressed in the manuscript.

COLLECTION

07/10/2019

Research Article

A Cyclin A—Myb-MuvB—Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cycles

Rotelli and colleagues define a Cyclin-A-regulated mitotic network in Drosophila whose downregulation promotes the switch from mitotic cycles to endoreplication cycles in induced and developmental endoreplicating cells (iECs and devECs). The authors further show that repression of this network in iECs is sufficient to induce endoreplication without reduced expression of S phase genes that is common among devECs.

Image credit: Michael D. Rotelli and colleagues

A Cyclin A—Myb-MuvB—Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cycles

Recently Published Articles

Current Issue

Current Issue June 2019

07/08/2019

Research Article

Analysis of the genetic basis of height in large Jewish nuclear families

Rare variants with large effects have been suggested to account for some of the missing heritability of height, but detection of such variants in GWAS requires very large sample sizes. Here, Zeevi et al conduct a family-based linkage study of height in a cohort of very large nuclear families, with an average of 12 and a maximum of 20 siblings. The authors detect many more QTLs than previous family-based studies of height, despite a sample size of only 397 participants.

Image credit: Danny Zeevi and colleagues

Analysis of the genetic basis of height in large Jewish nuclear families

07/05/2019

Research Article

The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals

In this study, Rohlfing, Eckenroth et al solve the crystal structure of C. difficile CspC, a soluble pseudoprotease used to sense bile acids which the bacterium uses to induce germination. Guided by this structure, the authors identify mutations that alter the sensitivity of C. difficile spores to bile acids and amino acid and calcium co-germinants.

Image credit: Rohlfing, Eckenroth and colleagues

The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals

07/03/2019

Research Article

Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene

Here, Aabida Saferali and colleagues identify genetic variants that are associated both with chronic obstructive pulmonary disease (COPD) risk and RNA splicing. In particular, the authors find that a COPD-associated variant of previously unknown function may contribute to the inclusion of a new exon in the FBXO38 gene.

Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene

Image credit: Aabida Saferali and colleagues

07/03/2019

Research Article

scoreInvHap: Inversion genotyping for genome-wide association studies

In this study, Carlos Ruiz-Arenas and colleagues propose a new method, scoreInvHap, to call individual inversion genotypes from their haplotype similarity. The authors show that scoreInvHap has a high performance when analyzing heterogeneous sources of SNP data.

scoreInvHap: Inversion genotyping for genome-wide association studies

Image credit: Carlos Ruiz-Arenas and colleagues

07/01/2019

Research Article

A secretion-enhancing cis regulatory targeting element (SECReTE) involved in mRNA localization and protein synthesis

How mRNAs encoding secreted and membrane proteins (mSMPs) reach the ER, and whether the process is translation-independent, remains unknown. Here, Cohen-Zontag et al identify a cis-acting sequence element in mSMPs that appears to facilitate mRNA stability and localization to the ER and, more importantly, enhances protein secretion.

A secretion-enhancing cis regulatory targeting element (SECReTE) involved in mRNA localization and protein synthesis

Image credit: Osnat Cohen-Zontag and colleagues

06/24/2019

Opinion Piece

Solving the missing heritability problem

In this Opinion Piece, Alexander Young discusses the 'missing heritability problem' - the gap between heritability estimates from genotype and twin data. 

Solving the missing heritability problem

Image credit: Alexander I. Young

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