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Mixed methods

July 15, 2020

Mixed methods

Image credit: Rube Goldberg, Wikimedia Commons, CC0

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Read the full Collection of Topic Pages published in PLOS Genetics.

Collection

06/24/2020

Research Article

Alpha- and beta-adrenergic octopamine receptors in muscle and heart are required for Drosophila exercise adaptations

Here, Sujkowski et al perform tissue- and adult-specific knockdown of alpha- and beta-adrenergic octopamine receptors in several target tissues, and find that reduced expression of Octβ1R in adult muscles abolishes exercise-induced improvements in endurance, climbing speed, flight, cardiac performance and fat-body catabolism in male Drosophila. 

Image credit: Alyson Sujkowski and colleagues

Alpha- and beta-adrenergic octopamine receptors in muscle and heart are required for Drosophila exercise adaptations

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Current Issue

Current Issue June 2020

06/22/2020

Research Article

Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)

There are four cone photoreceptors responsible for colour vision in zebrafish: red, green, blue, and UV. In this study, Deveau et al the role of the thyroid hormone receptor trβ2 in photoreceptor development and function in zebrafish. The authors find that, when trβ2 is knocked out, fish become red colourblind and the contributions of the other three cone types shift. 

Image credit: Ciana Deveau and colleagues

Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)

07/22/2020

Research Article

Reciprocal regulation between nicotinamide adenine dinucleotide metabolism and abscisic acid and stress response pathways in Arabidopsis

Nicotinamide adenine dinucleotide (NAD) is a coenzyme essential for metabolisms and signal transduction in all living organisms. Hong, Wang et al show that a mutation in QS, which causes reduced levels of NAD, influences the ABA signal transduction in Arabidopsis, suggesting a possible conserved role of NAD in abiotic stress response in plants.

Image credit: Yechun Hong, Zhen Wang and colleagues

Reciprocal regulation between nicotinamide adenine dinucleotide metabolism and abscisic acid and stress response pathways in Arabidopsis

06/18/2020

Research Article

VolcanoFinder: genomic scans for adaptive introgression

Setter, Mousset and colleagues present an analytically-tractable model for the effects of adaptive introgression on non-adaptive genetic variation in the genomic region surrounding the beneficial allele. The result is a characteristic volcano-shaped pattern of increased variability that arises around the positively-selected site, and the authors introduce an open-source method VolcanoFinder to detect this signal in genomic data. 

VolcanoFinder: genomic scans for adaptive introgression

Image credit: Setter, Mousset and colleagues

06/12/2020

Research Article

Phylogenetic background and habitat drive the genetic diversification of Escherichia coli

Touchon et al analyse non-clinical isolates of Escherichia coli to assess the mechanisms of gene repertoire diversification in light of isolation sources and phylogeny. The authors show that gene repertoires evolve so rapidly by high turnover of mobile genetic elements that epidemiologically indistinguishable strains can be phenotypically heterogeneous.

Phylogenetic background and habitat drive the genetic diversification of Escherichia coli

Image credit: Marie Touchon and colleagues

06/17/2020

Research Article

Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves

Neural crest (NC) cells are pluripotent embryonic stem cells that originate from neural tissue during early embryogenesis and contribute to development of the eye. Here, Takamiya et al find that two waves of NC cell populations with different properties contribute to distinct parts of the eye. 

Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves

Image credit: Masanari Takamiya and colleagues

04/23/2020

Review

Placental imprinting: Emerging mechanisms and functions

Courtney Hanna describes novel approaches regulating imprinted genes, those that are expressed from only one copy, depending on which parent they were inherited from, in mouse models.

Placental imprinting: Emerging mechanisms and functions

Image credit: Courtney W. Hanna

04/16/2020

Review

Deconstructing cerebellar development cell by cell

Max J. van Essen, Samuel Nayler and colleagues describe new discoveries of developmental mechanisms that generate cerebellar neural diversity, using single-cell sequencing in mouse and parallel human studies.

Deconstructing cerebellar development cell by cell

Image credit: van Essen, Nayler and colleagues

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