May 13, 2021
Image credit: Jun Xie, Yongchao Han and Mengli Shi
05/25/2021
Research Article
Shah et al. analyze genome-wide polymorphisms in 140 Plasmodium falciparum isolates from a longitudinal study in Malawi. They identify 25 genes that encode possible targets of naturally acquired immunity to malaria, which could have potential as vaccine candidates.
Image credit: Adrian V. S. Hill, 10.1098/rstb.2011.0091
Current Issue June 2021
05/13/2021
Research Article
Hoskens et al. reduce multivariate 3D facial shape variability into univariate measurements that preserve structural complexity. They identify many heritable loci, including several in regions related to embryonic facial development and craniofacial malformations.
Image credit: Hoskens et al., pgen.1009528
05/20/2021
Research Article
Carty et al. study the role of the centromere component CENP-C in controlling germline stem cell divisions in the Drosophila ovary. They find that CENP-C is critical for correct centromere assembly, and its depletion in germline stem cells disrupts the balance of stem and daughter cells in the developing ovary, impacting cell fate.
Image credit: Carty et al., pgen.1009247
05/18/2021
Research Article
Sanchez-Rebato et al. show that the chromatin-remodeling protein RAD54 is required for the repair of meiotic double strand breaks by RAD51 in the plant Arabidopsis thaliana, and that this function is downstream of the meiotic role of RAD51 in supporting the activity of DMC1.
Image credit: Sanchez-Rebato et al., pgen.1008919
05/20/2021
Research Article
He et al. discover that suppression of the transcription factor LET-607/CREBH, a regulator of cellular defense and proteostatic responses, triggers adaptive induction of DAF-16-dependent stress responses in C. elegans. This suppression improves stress resistance and extends C. elegans lifespan in a DAF-16-dependent manner.
Image credit: He et al., pgen.1009573
05/17/2021
Research Article
Sinha et al. identified a F-BAR domain protein in the necrotrophic fungus Ascochyta rabiei and demonstrate its involvement in endosome-dependent fungal virulence on the host plant Cicer arietinum (chickpea).
Image credit: Sinha et al., pgen.1009137
05/20/2021
Review
Hivert et al. present the Falconer ShinyApp, a user-friendly web tool that shows how the combination of gene action and allele frequencies at causal loci translate to genetic variance and genetic variance components for a complex trait.
Image credit: Darwin Laganzon, Pixabay
05/13/2021
Review
Alan Herbert reviews the role of MDA5 helicase in inducing Z-RNA formation by Alu inverted repeat elements as well as the less characterized roles of other helicases in modulating innate immune responses.
Image credit: Alan Herbert, pgen.1009513
04/22/2021
Viewpoints
Nielsen et al. comment on two recent studies that have taken advantage of MAVE technology to investigate loss-of-function variants in MSH2, which cause the cancer-predisposing Lynch Syndrome.
Image credit: Nielsen et al., pgen.1009496
04/22/2021
Perspective
Chang and Malik highlight a new study (pgen.1009418) showing an active co-evolutionary arms race between DNA and protein components of the meiotic machinery in Mimulus, with consequences for individual fitness and molecular divergence.
Image credit: Finseth et al., pgen.1009418
Five new journals unified in addressing global health and environmental challenges are now ready to receive submissions: PLOS Climate, PLOS Sustainability and Transformation, PLOS Water, PLOS Digital Health, and PLOS Global Public Health
The COVID-19 Collection highlights all content published across the PLOS journals relating to the COVID-19 pandemic in 2019-21.
PLOS ONE is now accepting submissions of Lab Protocols, a peer-reviewed article collaboration with protocols.io, and Study Protocols, an article that credits the work done prior to producing and publishing results.
A collection of free training and resources for peer reviewers of PLOS journals—and for the peer review community more broadly—drawn from research and interviews with staff editors, editorial board members, and experienced reviewers.
PLOS Computational Biology's "Ten Simple Rules" articles provide quick, concentrated guides for mastering some of the professional challenges research scientists face in their careers.
PLOS Genetics releases a new curated collection in partnership with PLOS ONE, celebrating the innovative agricultural research taking place in tropical countries.
Congratulations to PLOS Genetics Associate Editors Denise Montell, Anita Hopper, Joe Heitman, and Marisa Bartolomei for being elected members of the National Academy!
Congratulations to PLOS Genetics Associate Editors Sue Jinks-Robertson and Sarah A. Tishkoff for being elected members of the American Academy in the area of biological sciences!
PLOS Genetics announces a new collection on Human Genetic Admixture, introduced by a review from Korunes and Goldberg that discusses recent advances and future directions for the field.
Congratulations to Epigenetics Section Editor Wendy Bickmore for being appointed CBE in recognition of her services to biomedical sciences and to women in science!
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