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05/08/2020

Research Article

An EHBP-1-SID-3-DYN-1 axis promotes membranous tubule fission during endocytic recycling

Jinghu Gao, Linyue Zhao et al identify SID-3 as a new interactor of EHBP-1, a protein that functions with RAB-10 to generate and maintain recycling endosomal tubules. The authors find that SID-3 functions downstream of EHBP-1 to encourage membrane scission, and that ectopic expression of DYN-1 improves recycling transport in SID-3-depleted cells. 

Image credit: Gao, Zhao and colleagues

An EHBP-1-SID-3-DYN-1 axis promotes membranous tubule fission during endocytic recycling

Recently Published Articles

Current Issue

Current Issue April 2020

05/07/2020

Research Article

Additive and mostly adaptive plastic responses of gene expression to multiple stress in Tribolium castaneum

In this study, Eva L. Koch and Frédéric Guillaume combine measurements of offspring number with gene expression data to study responses of the model organism T. castaneum to single and joint effects of drought and heat. The authors find that higher temperatures result in a stronger reduction of offspring number and a larger number of differently expressed genes compared to reduced humidity.

Image credit: GLady, Pixabay, CC0

Additive and mostly adaptive plastic responses of gene expression to multiple stress in Tribolium castaneum

05/07/2020

Research Article

Separable, Ctf4-mediated recruitment of DNA Polymerase α for initiation of DNA synthesis at replication origins and lagging-strand priming during replication elongation

Using the model eukaryote S. cerevisiae, Porcella et al modulate cellular levels of Pol α and interrogate the impact of this perturbation on replication initiation on DNA synthesis and cellular viability. The authors find that that Pol α can associate dynamically at the replication fork for initiation on both strands.

Image credit: Sarina Y. Porcella and colleagues

Separable, Ctf4-mediated recruitment of DNA Polymerase α for initiation of DNA synthesis at replication origins and lagging-strand priming during replication elongation

05/05/2020

Research Article

Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma

Using more than 514,000 individuals with European ancestries in two population cohorts in the UK and Finland, Yosuke Tanigawa and colleagues present a strategy to scan for rare protein-altering variants affecting intraocular pressure. The authors identify multiple ANGPTL7 variants that lower itraocular pressure and protect against glaucoma.

Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma

Image credit: Kate Whitley, Wellcome Collection, CC-BY

05/01/2020

Research Article

An Out-of-Patagonia migration explains the worldwide diversity and distribution of Saccharomyces eubayanus lineages

Here, Nespolo, Villarroel and colleagues demonstrate that S. eubayanus isolates from Patagonia have the greatest genetic diversity of all collected isolates, likely suggesting co-occurrence in Patagonia. Some isolates exhibited significant phenotypic differences for traits such as high temperature and ethanol tolerance.

An Out-of-Patagonia migration explains the worldwide diversity and distribution of Saccharomyces eubayanus lineages

Image credit: Alexas_Fotos, Pixabay

05/04/2020

Research Article

Single-nucleus RNA-seq identifies divergent populations of FSHD2 myotube nuclei

Here, Jiang, Williams et al use single-nucleus RNA-seq to observe native DUX4 expression at the single-nucleus level in FSHD2 patient-derived myotubes. Using this technique, the authors identify identify two populations of FSHD myotube nuclei with distinct transcriptional profiles.

Single-nucleus RNA-seq identifies divergent populations of FSHD2 myotube nuclei

Image credit: Jiang, Williams and colleagues

04/23/2020

Review

Placental imprinting: Emerging mechanisms and functions

Courtney Hanna describes novel approaches regulating imprinted genes, those that are expressed from only one copy, depending on which parent they were inherited from, in mouse models.

Placental imprinting: Emerging mechanisms and functions

Image credit: Courtney W. Hanna

04/16/2020

Review

Deconstructing cerebellar development cell by cell

Max J. van Essen, Samuel Nayler and colleagues describe new discoveries of developmental mechanisms that generate cerebellar neural diversity, using single-cell sequencing in mouse and parallel human studies.

Deconstructing cerebellar development cell by cell

Image credit: van Essen, Nayler and colleagues

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