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Topic Pages

Read the full Collection of Topic Pages published in PLOS Genetics.

Collection

09/09/2021

Research Article

Genome-wide methylation data improves dissection of the effect of smoking on body mass index

Amador et al. explore the effect of smoking and genome-by-smoking interactions on obesity related traits. They find that self-reported smoking status contributes only 2% of BMI variation, increasing to 22% when estimated using DNA methylation. Their work highlights the potential of using biomarkers to proxy lifestyle measures and improve models for complex traits.

Image credit: Tumisu, Pixabay

Genome-wide methylation data improves dissection of the effect of smoking on body mass index

Recently Published Articles

Current Issue

Current Issue October 2021

09/27/2021

Research Article

A signature of Neanderthal introgression on molecular mechanisms of environmental responses

Findley et al. test gene expression response to in vitro treatments to identify genes and regulatory variants that may have played an important role in adaptations to local environments. They find that SNPs with introgressed Neanderthal alleles disrupt binding of transcription factors important for environmental responses, including hypoxia, and for glucose metabolism.

Image credit: David Mark, Pixabay

A signature of Neanderthal introgression on molecular mechanisms of environmental responses

09/16/2021

Research Article

On cross-ancestry cancer polygenic risk scores

Fritsche et al. contrast the utility of breast and prostate cancer polygenic risk scores derived from external European-ancestry-based GWAS across African, East Asian, European, and South Asian ancestry groups. They highlight a compromise solution for PRS research to compensate for the lack of diversity in well-powered European GWAS efforts while recruitment of diverse participants in the field catches up.

On cross-ancestry cancer polygenic risk scores

Image credit: Miguel Á. Padriñán, Pixabay

09/22/2021

Research Article

Tramtrack acts during late pupal development to direct ant caste identity

Glastad et al. explore the link between changes in hormonal signaling, cell-specific regulation of gene expression, and changes in neuronal connections in the ant Camponotus floridanus. They show that the protein tramtrack binds to the epigenetic corepressor CoREST to give rise to caste-based gene expression.

Tramtrack acts during late pupal development to direct ant caste identity

Image credit: Glastad et al., pgen.1009801

09/27/2021

Research Article

Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response

Filograna et al. develop a mouse model lacking Mitofusin 2, a key regulator of mitochondrial network homeostasis. They find that mitochondrial dysfunction triggers an early immune response, and that neuronal death may be promoted non-cell autonomously by the cross-talk and activation of surrounding glial cells.

Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response

Image credit: Roberta Filograna & Mara Mennuni

10/19/2021

Collection

Domestic Animal Genetics

Curated by and introduced with an Editorial from Associate Editor Tosso Leeb, the collection presents a selection of PLOS Genetics research that exemplifies recent progress in domestic animal genetics and areas for future development.

Domestic Animal Genetics

Image credit: Pete Linforth, Pixabay

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