Reduction of Derlin activity suppresses Notch-dependent tumours in the C. elegans germ line

Fritsche et al. contrast the utility of breast and prostate cancer polygenic risk scores derived from external European-ancestry-based GWAS across African, East Asian, European, and South Asian ancestry groups. They highlight a compromise solution for PRS research to compensate for the lack of diversity in well-powered European GWAS efforts while recruitment of diverse participants in the field catches up.

Glastad et al. explore the link between changes in hormonal signaling, cell-specific regulation of gene expression, and changes in neuronal connections in the ant Camponotus floridanus. They show that the protein tramtrack binds to the epigenetic corepressor CoREST to give rise to caste-based gene expression.

Filograna et al. develop a mouse model lacking Mitofusin 2, a key regulator of mitochondrial network homeostasis. They find that mitochondrial dysfunction triggers an early immune response, and that neuronal death may be promoted non-cell autonomously by the cross-talk and activation of surrounding glial cells.