Genome-wide identification of RETINOBLASTOMA RELATED 1 binding sites in Arabidopsis reveals novel DNA damage regulators
The human Retinoblastoma (pRb) tumor suppressor is a key cell cycle regulator with homologs in most eukaryotes. Here, Bouyer, Heese et al describe a genome-wide DNA-binding study of the Arabidopsis pRb homolog RBR1. The authors find that RBR1 binds to roughly 1000 genes and 500 transposons, and identify new genes necessary for growth upon DNA damage.
Image credit: Daniel Bouyer, Maren Heese and colleagues