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12/27/2022

Research Article

Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits

When studying genetic variants that associate with disease traits in humans, smaller-scale studies can often have inadequate power to discover new genetic associations. Here, Chun & Akle et al use a small genetic study of Obstructive Sleep Apnea (OSA), to introduce a strategy that both helps find genetic associations and proposes biological hypotheses for the mechanisms behind those associations.

Image credit: Isabella and Zsa Fischer, Unsplash

Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits

Recently Published Articles

Current Issue

Current Issue December 2022

01/05/2023

Viewpoints

Beyond the average: An updated framework for understanding the relationship between cell growth, DNA replication, and division in a bacterial system

Our understanding of the bacterial cell cycle is framed largely by population-based experiments that focus on the behavior of idealized average cells. This Viewpoint proposes an updated and agnostic framework that quantitatively accounts for stochastic variations in single-cell dynamics and the impact of medium composition on cell growth and cell cycle progression.



Image credit: CDC

Beyond the average: An updated framework for understanding the relationship between cell growth, DNA replication, and division in a bacterial system

12/08/2022

Research Article

Denisovan introgression has shaped the immune system of present-day Papuans

Humans of Papuan ancestry owe roughly 5% of their genome to Denisovans, a poorly characterised archaic hominin. Vespasiani et al assess the consequences of archaic admixture across a multitude of different cell types and functional elements. In Papuans, Denisovan DNA, but not Neanderthal, strongly and consistently affects immune cells and immune-related processes of potential evolutionary relevance. 



Image credit: pgen.1010470

Denisovan introgression has shaped the immune system of present-day Papuans

12/27/2022

Research Article

Gene drive designs for efficient and localisable population suppression using Y-linked editors

Releasing sterile males for pest control can be successful, but is challenging when the target population is large or the species difficult to rear. Here, Geci et al build on previous work to show that Y-linked editors to kill or sterilise female descendants can be used in more efficient gene drive designs that would spread over successive generations beyond the region of release.



Gene drive designs for efficient and localisable population suppression using Y-linked editors

Image credit: pgen.1010550

01/17/2023

Research Article

A dedicate sensorimotor circuit enables fine texture discrimination by active touch

Yu & Guo report that fruit flies are most attracted to chewy food, rather than those with too low or too high stiffness. A group of mechanosensory neurons on the fly proboscis are activated during active probing on food surface and promote ingestion by activating the sweet-sensing neurons.



A dedicate sensorimotor circuit enables fine texture discrimination by active touch

Image credit: pgen.1010562

10/27/2022

Review

Formation of benign tumours by stem cell deregulation

Valet & Narbonne outline progress made in our understanding of in vivo stem cell regulation, concluding that 2 types of stem cell deregulations can provoke the formation of benign tumors.

Formation of benign tumours by stem cell deregulation

Image credit: pgen.1010434

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PLOS Genetics | ISSN: 1553-7404 (online)