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Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds

December 6, 2018

Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds

Image credit: Kathryn Robertson

Topic Pages Collection

This collection aims to increase the coverage of computational biology and genetics-related topics                                                  in Wikipedia by rewarding authors with a citable, PubMed-indexed version of the living document on Wikipedia.

Collection

11/30/2018

Research Article

Genome-wide identification of RETINOBLASTOMA RELATED 1 binding sites in Arabidopsis reveals novel DNA damage regulators

The human Retinoblastoma (pRb) tumor suppressor is a key cell cycle regulator with homologs in most eukaryotes. Here, Bouyer, Heese et al describe a genome-wide DNA-binding study of the Arabidopsis pRb homolog RBR1. The authors find that RBR1 binds to roughly 1000 genes and 500 transposons, and identify new genes necessary for growth upon DNA damage.

Image credit: Daniel Bouyer, Maren Heese and colleagues

Genome-wide identification of RETINOBLASTOMA RELATED 1 binding sites in Arabidopsis reveals novel DNA damage regulators

Recently Published Articles

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Current Issue

Current Issue November 2018

11/30/2018

Research Article

Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition

During endothelial-to-mesenchymal transition (EndMT), endothelial cells lose their characteristics and acquire mesenchymal-like properties. Here, Nagai and colleagues show that reduced expression of ERG and FLI1 trigger EndMT. They also find that ERG and FLI1 expression is downregulated in tumors, suggesting EndMT is triggered in the tumor microenvironment.

Image credit: Nao Nagai and colleagues

Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition

12/03/2018

Research Article

Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis

Here, Darlay et al use dense single nucleotide polymorphism (SNP) data to investigate the underlying causes of Primary Biliary Cholangitis (PBC). The authors show that associations between PBC and variants in the human leukocyte antigen (HLA) gene can be largely explained by variation at five amino acid positions.

Image credit: Rebecca Darlay and colleagues

Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis

11/26/2018

Research Article

Anisotropic Crb accumulation, modulated by Src42A, is coupled to polarised epithelial tube growth in Drosophila

Here, Olivares-Castiñeira and Llimargas use the Drosophila tracheal system as a model to investigate the mechanisms underlying size regulation of tubular organs. They find that Src42A is required for anisotropic accumulation of Crumbs during tube elongation, providing new insights into how organ growth is controlled.

Anisotropic Crb accumulation, modulated by Src42A, is coupled to polarised epithelial tube growth in Drosophila

Image credit: Ivette Olivares-Castiñeira & Marta Llimargas

11/26/2018

Research Article

A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote

Meiotic drivers are selfish alleles that subvert gametogenesis to increase their transmission into progeny. Here, Bravo Núñez et al find that an additional wtf gene, wtf13, found in intensely studied lab strains, is also a meiotic driver. The authors further find that this driver is only capable of driving in the absence of wtf18-2, which mimics the antidote of wtf13.

A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote

Image credit: María Angélica Bravo Núñez and colleagues

11/21/2018

Perspective

The many fates of tissue regeneration

Abdullah and Duronio comment on work by Verghese and Su, who show that stem-cell–like behavior can be induced in Drosophila cells in response to tissue damage resulting from ionizing radiation.

The many fates of tissue regeneration

Image credit: Christopher Abdullah and Robert J. Duronio

11/15/2018

TOPIC PAGE

Selfish genetic elements

Ågren and Clark discuss selfish genetic elements: once dismissed as genetic curiosities, with little relevance for evolution, they are now recognized to affect a wide swath of biological processes. This article was also published as a live page on Wikipedia.

Selfish genetic elements

Image credit: Ågren and Clark

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