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Current Issue September 2022

09/08/2022

Research Article

COVID-19 infection and transmission includes complex sequence diversity

Chan et al. characterize the complex sequence diversity of individual COVID-19 infections. The sequence polymorphism they observe shows that SARS-CoV-2 infections are heterogeneous mixtures. They suggest that minority alleles in earlier SARS-CoV-2 infections may play an important role in the continuing evolution of new variants of concern.

Image credit: CDC Public Health Image Library

COVID-19 infection and transmission includes complex sequence diversity

09/07/2022

Research Article

Localized variation in ancestral admixture identifies pilocytic astrocytoma risk loci among Latino children

Li et al. use data from the California Biobank to show that the risk of a common pediatric brain tumor increases when a Latino child has a higher proportion of European ancestry. This ancestral risk is localized to specific regions of the genome, especially in Chromosome 6 near the SNX14 gene, which is associated with cancer-related growth signaling pathway described by MAPK/ERK.

Image credit: National Cancer Institute, Unsplash

Localized variation in ancestral admixture identifies pilocytic astrocytoma risk loci among Latino children

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PLOS Genetics | ISSN: 1553-7404 (online)