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Current Issue May 2021

04/22/2021

Research Article

Selfish chromosomal drive shapes recent centromeric histone evolution in monkeyflowers

Finseth et al. study the wildflower Mimulus guttatus and show that both inter-specific and intra-population differences in CenH3A affect centromeric drive in hybrids, and that adaptive evolution of CenH3A has followed the recent and costly spread of the driver in a wild population. Their results results demonstrate an active co-evolutionary arms race between DNA and protein components of the meiotic machinery in Mimulus.

Image credit: Finseth et al., pgen.1009418

Selfish chromosomal drive shapes recent centromeric histone evolution in monkeyflowers

04/16/2021

Research Article

Tempo and mode in karyotype evolution revealed by a probabilistic model incorporating both chromosome number and morphology

Yoshida and Kitano build a probabilistic model of karyotype evolution based on the “karyograph”, which treats karyotype evolution as a walk on the two-dimensional space representing the chromosome and arm numbers. They apply the model to two large taxonomic groups of fish, and a small plant group.

Image credit: Yoshida and Kitano, pgen.1009502

Tempo and mode in karyotype evolution revealed by a probabilistic model incorporating both chromosome number and morphology

04/08/2021

Research Article

Sperm acrosome overgrowth and infertility in mice lacking chromosome 18 pachytene piRNA

Choi et al. show that spermatozoa in gene-edited mice lacking a BTBD18 targeted pachytene piRNA cluster on Chr18 have severe sperm head dysmorphology, poor motility, impaired acrosome exocytosis, zona pellucida penetration and are sterile. They reveal a central role of pachytene piRNAs in controlling spermiogenesis and male fertility.

Sperm acrosome overgrowth and infertility in mice lacking chromosome 18 pachytene piRNA

Image credit: Choi et al., pgen.1009485

04/15/2021

Research Article

Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease

Ingles-Prieto et al. use optogenetics to deliver cell type-specific pro-survival signals and efficiently suppress disease phenotypes in Drosophila and human cells. This work has the potential to inspire novel strategies towards a spatio-temporal regulation of tissue repair.

Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease

Image credit: Vanessa Zheden, Alvaro Ingles-Prieto and Harald Janovjak

05/20/2021

Review

Gene action, genetic variation, and GWAS: A user-friendly web tool

Hivert et al. present the Falconer ShinyApp, a user-friendly web tool that shows how the combination of gene action and allele frequencies at causal loci translate to genetic variance and genetic variance components for a complex trait.

Gene action, genetic variation, and GWAS: A user-friendly web tool

Image credit: Darwin Laganzon, Pixabay

04/22/2021

Perspective

Putting the brakes on centromere drive in Mimulus

Chang and Malik highlight a new study (pgen.1009418) showing an active co-evolutionary arms race between DNA and protein components of the meiotic machinery in Mimulus, with consequences for individual fitness and molecular divergence.

Putting the brakes on centromere drive in Mimulus

Image credit: Finseth et al., pgen.1009418

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