The topoisomerase 3α zinc-finger domain T1 of Arabidopsis thaliana is required for targeting the enzyme activity to Holliday junction-like DNA repair intermediates
Dorn et al investigate the role of zinc-finger domains
(ZFDs), a component of Topoisomerase 3α. They find ZFD T1 is required for targeting the topoisomerase activity to Holliday junction-like recombination intermediates to enable their processing.
Image credit: Annika Dorn and colleagues