November 17, 2021
Image credit: Cai et al.
11/17/2021
Research Article
Girard et al. used a transgenic Drosophila model of Parkinson’s disease in which human αSyn is expressed in photoreceptor neurons, to find that that binding of αSyn to liquid droplets contributes to the pathogenic misfolding and aggregation of αSyn in neurons.
Image credit: Victor Girard
Current Issue November 2021
11/08/2021
Research Article
Sang et al. identify the single Drosophila zonula occludens-1 (ZO-1) protein Polychaetoid (Pyd) as a new regulator of the Hippo pathway during the blue- and green-sensitive PR subtype binary fate choice. They also find that Pyd represses the activity of Su(dx), a E3 ligase that negatively regulates Pez and can physically interact with Pyd, during PR subtype fate specification.
Image credit: Baotong Xie
11/11/2021
Research Article
Macías et al. discover that two domesticated yeast species, Saccharomyces cerevisiae and S. uvarum, have acquired similar chromosomal rearrangements to convergently adapt to the presence of sulfite used in wine production.
Image credit: Photo Mix, Pixabay
11/09/2021
Research Article
Bengtsen et al. perform a genome-wide comparison of the epigenetic landscape in (fast) extensor digitorum longus and (slow) soleus muscle and reveal distinct regulatory programs involving distal enhancers, including a glycolytic super-enhancer in the EDL.
Image credit: Einar Eftestøl
11/09/2021
Research Article
Bočkaj et al. uncover a role for H3.3 glioma mutations in DNA replication under stress conditions altered by the K27M mutation, promoting genomic instability and potentially glioma development.
Image credit: Sophia Bruggeman
11/15/2021
Research Article
Wirick et al. define a new role for the FOXO protein DAF-16 in promoting multipotency during the quiescent C. elegans dauer larva stage. These findings may be relevant to mammals where the orthologs of daf-16 and lin-41 are important in stem cell maintenance and opposing differentiation.
Image credit: Matthew J. Wirick
12/09/2021
Review
Basilicata & Keller Valsecchi present a review on the biology of gene dosage at the crossroads between evolutionary benefit and pathogenicity during disease.
Image credit: Veronique Juvin
10/19/2021
Collection
Curated by and introduced with an Editorial from Associate Editor Tosso Leeb, the collection presents a selection of PLOS Genetics research that exemplifies recent progress in domestic animal genetics and areas for future development.
Image credit: Pete Linforth, Pixabay
10/14/2021
Review
Diaz-Cuadros et al. contrast two different processes in two distantly related phyla to elucidate the deep logic of patterning by oscillatory and sequential gene activities.
Image credit: Diaz-Cuadros et al.
09/09/2021
Viewpoints
Kaan et al examine the practicality of an international moratorium on human germline genome editing, and advocate for a community engagement approach instead.
Image credit: mcmurryjulie, Pixabay
Five new journals unified in addressing global health and environmental challenges are now ready to receive submissions: PLOS Climate, PLOS Sustainability and Transformation, PLOS Water, PLOS Digital Health, and PLOS Global Public Health
The COVID-19 Collection highlights all content published across the PLOS journals relating to the COVID-19 pandemic in 2019-21.
PLOS ONE is now accepting submissions of Lab Protocols, a peer-reviewed article collaboration with protocols.io, and Study Protocols, an article that credits the work done prior to producing and publishing results.
A collection of free training and resources for peer reviewers of PLOS journals—and for the peer review community more broadly—drawn from research and interviews with staff editors, editorial board members, and experienced reviewers.
PLOS Computational Biology's "Ten Simple Rules" articles provide quick, concentrated guides for mastering some of the professional challenges research scientists face in their careers.
PLOS Genetics releases a new curated collection in partnership with PLOS ONE & PLOS Biology, celebrating research on environmentally, socially, and economically sustainable agricultural practices.
PLOS Genetics welcomes several new Associate Editors to our board: Pablo Wappner, Jackson Champer, Tanja Slotte, Aaron P. Mitchell, Ken M. Cadigan, Tim Reddy, Melissa Wasserstein, Sudha Iyengar, Martien Groenen, Lynn M. Riddiford, Karen Avraham, Anne O'Donnell Luria, & Neil Hanchard.
Congratulations to the PLOS Genetics editors elected to the National Academy of Medicine: Sarah A. Tishkoff; National Academy: Denise Montell, Anita Hopper, Joe Heitman, & Marisa Bartolomei; and American Academy (biological sciences): Sue Jinks-Robertson & Sarah A. Tishkoff.
PLOS Genetics releases a new curated collection in partnership with PLOS ONE, celebrating the innovative agricultural research taking place in tropical countries.
PLOS Genetics announces a new collection on Human Genetic Admixture, introduced by a review from Korunes and Goldberg that discusses recent advances and future directions for the field.
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