February 21, 2025

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Disentangling the mutational effects on protein stability and interaction of human MLH1

In this study, the authors use high-throughput experimental approaches to test how missense mutations affect the cellular abundance of MLH1 and the interaction with its partner, PMS2. They find that many variants disrupting the interaction with PMS2 also lead to reduced cellular abundance levels, suggesting a strong relationship between protein stability and interaction in MLH1.

Image credit: pgen.1011681

Disentangling the mutational effects on protein stability and interaction of human MLH1

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Current Issue April 2025

04/17/2025

Research article

Mammary gland multi-omics data reveals new genetic insights into milk production traits in dairy cattle

Here, the authors focus on functional classes such as mammary-specific genes, lactation-associated genes, non-coding RNAs, RNA editing sites, DNA methylation and expression quantitative trait loci. Analyzing 3 million variants in 23,566 Holstein bulls, they identify key variants and functional classes that contribute significantly to genetic variation in milk production.

Image credit: pgen.1011675

Mammary gland multi-omics data reveals new genetic insights into milk production traits in dairy cattle

04/10/2025

research article

Exploring the molecular basis of the genetic correlation between body mass index and brain morphological traits

Here, the authors investigate the genetic variants that affect both obesity and brain morphology, identifying 21 genes whose expression affects both body mass index and morphological measures obtained from brain magnetic resonance imaging data. These results provide new insight into the complex relationships between the brain and obesity.

Image credit: pgen.1011658

Exploring the molecular basis of the genetic correlation between body mass index and brain morphological traits

04/09/2025

research article

Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways

In this study, the authors use a 3D genomic approach to map how genetic variants linked to neurodegenerative diseases interact with genes in different brain cell types. Their analysis reveals that genetic risk for Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis is particularly enriched in microglia, the brain’s immune cells.

Image credit: pgen.1011407

04/07/2025

research article

Conserved chromatin regulators control the transcriptional immune response to intracellular pathogens in Caenorhabditis elegans

In this study, the authors show that transcriptional regulators, previously linked to development in Caenorhabditis elegans, also control immune responses. They also discovered that other chromatin regulators similarly repress IPR gene expression, highlighting a new role in immunity for these conserved regulators of development.

Image credit: pgen.1011444

04/15/2025

research article

Germline mutation rates and fine-scale recombination parameters in zebra finch

Here, the authors characterize properties of mutation and recombination in the zebra finch, which, like other birds, differs from mammals in several potentially salient respects, including its karyotype and the mechanism by which recombination is directed to the genome. By sequencing the genomes of three-generation pedigrees, the authors identify de novo mutations and recombination events.

Image credit: pgen.1011661

04/11/2025

Research article

YebC2 resolves ribosome stalling and increases fitness of cells lacking EF-P and the ABCF ATPase YfmR

The authors' work in this study suggests that EF-P, YfmR, and YebC2 act independently to prevent ribosome stalling and are important for maintaining cellular fitness.

Image credit: pgen.1011633

04/30/2025

research article

Probing the limits of cis-acting gene regulation using a model of allelic imbalance quantitative trait loci

In this study, the authors show that in some tissues allelic imbalance is correlated with age; however, this correlation may be due to changes in the abundance of immune cell populations with age.

Image credit: pgen.1011446

04/21/2025

MEthods

Isolating selective from non-selective forces using site frequency ratios

A new statistical method is presented for estimating the distribution of strengths of natural selection acting on mutations in natural populations using the distribution of polymorphic site allele frequencies.

Image credit: pgen.1011427

04/02/2025

research article

A phage-encoded counter-defense inhibits an NAD-degrading anti-phage defense system

Here, the authors determine how an anti-phage defense system encoded by an integrative and conjugative element recognizes phage infection to cause cell death prior to the generation of phage progeny.

Image credit: pgen.1011551

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Submit your Lab and Study Protocols to PLOS ONE!

PLOS ONE is now accepting submissions of Lab Protocols, a peer-reviewed article collaboration with protocols.io, and Study Protocols, an article that credits the work done prior to producing and publishing results.
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What's happening at PLOS Genetics?

Discover Our Updated Editorial Board Webpage!

We're excited about our revised and synchronized Editorial Board webpage—now enhanced with a brand-new search functionality!

Easily find and explore board members with our improved layout and seamless navigation.
PLOS Genetics welcomes new Section Editors in 2024

We've been thrilled to welcome:

Marnie Blewitt, Giovanni Bosco, Gregory M. Cooper, Paula Cohen, Monica Colaiacovo, Danielle Garsin, Kent Hunter, Hongbin Ji, Zoltan Kutalik, Anne O'Donnell-Luria, Giorgio Sirugo, Pablo Wappner, and Fengwei Yu!
Harmit Malik receives Novitski Prize

Congratulations to Associate Editor Harmit Malik, who was awarded the Edward Novitski Prize by the Genetics Society of America for his work on genetic conflict. Harmit has also been elected as a new member of the American Academy of Arts & Sciences.

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