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Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes

September 18, 2018

Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes

Image credit: Jessica E. Spiewak and colleagues

2018 PLOS Genetics Research Prize

Find out more about the winning article by Timothy J. Mullen and Sarah M. Wignall here

2018 Prize Winners

Recently Published Articles

Current Issue

Current Issue August 2018

09/17/2018

REsearch article 

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16

CHIP is a multi-functional protein that bridges two opposing cellular processes: protein refolding and protein degradation. Shi, Rubel et al establish a new framework to better understand diseases involving the loss of CHIP function, the spectrum of disease-causing mutations, and the affected pathways. 

Image credit: Chang-he Shi, Carrie Rubel and colleagues

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16

09/10/2018

research article

Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina

In this study, Van Den Brink et al examine the consequences of removal or enforced Lipid Droplet (LD) accumulation on the health of retinal cells in flies and mice, and find that overexpression of the fatty acid transport protein (FATP) in retinal pigment cells induces accumulation of LDs in both transgenic flies and mice. 

Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina

Image credit: Daan M. Van Den Brink and colleagues

09/12/2018

research article

Robust Activation of Microhomology-mediated End Joining for Precision Gene Editing Applications

New gene editing tools precisely break DNA at pre-defined genomic locations, but cells repair these lesions using diverse pathways, leading to unpredictable outcomes. Here, Ata et al report on overcoming this obstacle by selectively directing DNA repair of double-stranded breaks through a less well known pathway termed Microhomology-mediated End Joining (MMEJ). 

Robust Activation of Microhomology-mediated End Joining for Precision Gene Editing Applications

Image credit: Hirotaka Ata and colleagues

09/13/2018

review

Structure and function of archaeal histones

Bram Henneman and colleagues discuss the many possibilities of archaeal histone involvement in transcription regulation.

Structure and function of archaeal histones

Image credit: Bram Henneman and coleagues

08/30/2018

review

PRDM9, a driver of the genetic map

Corinne Grey and colleagues discuss the current knowledge about the molecular features of PRDM9 as a DNA-binding protein and epigenetic modifier and how those features contribute to drive double strand break formation.

PRDM9, a driver of the genetic map

Image credit: Corine Grey and colleagues

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