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07/21/2021

Research Article

DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence

Fry et al. investigate the role of daf-18, a C. elegans ortholog of a human tumor suppressor, in maintaining primordial germ cell quiescence in L1 starvation. They find that maternal or zygotic daf-18 is sufficient to maintain cell cycle quiescence, that daf-18 acts in the germ line and soma, and that daf-18 affects timing of PGC divisions in fed animals.

Image credit: Amanda L. Fry

DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence

Recently Published Articles

Current Issue

Current Issue August 2021

07/19/2021

Research Article

A spectral theory for Wright’s inbreeding coefficients and related quantities

François and Gain describe the relationships between Wright’s inbreeding coefficient and principal component analysis for a model of K discrete populations, and provide an equivalent definition of the coefficient based on the decomposition of the genotype matrix into between and within-population matrices.

Image credit: François and Gain

A spectral theory for Wright’s inbreeding coefficients and related quantities

07/15/2021

Review

Tetrahymena meiosis: Simple yet ingenious

Loidl comparises the unconventional meiotic programs of Tetrahymena thermophila to those of higher multicellular organisms, and suggests this may reveal how extant meiosis evolved from proto-meiosis.

Image credit: Josef Loidl

Tetrahymena meiosis: Simple yet ingenious

09/02/2021

Perspective

Rhino breaks the deadlock in Drosophila testis

Molla Herman and Brasset highlight new research by Chen et al (pgen.1009591) on the Rhino-Deadlock-Cutoff complex's essential role in transposon repression in males.

Rhino breaks the deadlock in Drosophila testis

Image credit: Molla Herman and Brasset

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