PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease

Hédan et al. show that canine predisposition to histiocytic sarcoma is due to the additive effect of several risk haplotypes also involved in the predisposition of other hematopoietic cancers. The corresponding chromosomal regions in humans are involved in the predisposition of several cancers and are also associated with immune traits.

Wang et al. show that two copies of tethered Wg cause a non-specific Wg toxicity; but that even when the dose-tethered Wg is reduced, ovaries have negligible follicle stem cell proliferation and produce few eggs. They therefore find that extracellular Wg spreading is essential for follicle stem cell proliferation and oogenesis.

Zhou et al. find that the gene fru acts to control sex-specific development outside the nervous system (in the gonad). They also find that sex-specific fru expression can be regulated by Dsx, in addition to its Dsx-independent regulation, providing a new mechanism for fru regulation that may be broadly utilized.