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Collection

02/11/2021

Research Article

The impact of global and local Polynesian genetic ancestry on complex traits in Native Hawaiians

Sun et al., with the Samoan Obesity, Lifestyle, and Genetic Adaptations Study Group, show that a higher degree of Polynesian ancestry, which likely captures both genetic and non-genetic risk factors related to Native Hawaiian people and culture, is associated with increased risk for obesity, type-2 diabetes, and heart failure.

Image credit: Les Bohlen, Pixabay

The impact of global and local Polynesian genetic ancestry on complex traits in Native Hawaiians

Recently Published Articles

Current Issue

Current Issue March 2021

02/05/2021

Research Article

Regulation of ddb2 expression in blind cavefish and zebrafish reveals plasticity in the control of sunlight-induced DNA damage repair

Zhao et al. study DNA repair systems in the Somalian cavefish and suggest that Nucleotide Excision Repair (NER) function is retained in cavefish and is upregulated upon sunlight exposure. By comparing zebrafish, they reveal plasticity in the transcriptional and post transcriptional mechanisms regulating the repair of sunlight-induced DNA damage under long-term environmental challenges.

Image credit: Cavallari et al., pbio.1001142

Regulation of ddb2 expression in blind cavefish and zebrafish reveals plasticity in the control of sunlight-induced DNA damage repair

02/08/2021

Research Article

Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals

Claeys et al. investigate whether an individual’s Major Histocompatibility Complex (MHC) genotype determines cancer susceptibility through simulations of virtual cancer patients. They show that earlier reported HLA affinity differences are unrelated to the underlying MHC genotypes, but rather secondary to high frequencies of 13 driver mutations in 6 cancer genes.

Image credit: Claeys et al., pgen.1009368

Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals

02/04/2021

Research Article

Creating artificial human genomes using generative neural networks

Yelman et al. apply generative neural networks to genetic data to produce produce high quality realistic genomes. The novel, "artificial" genomes maintain many complex characteristics of real genomes and the heterogeneous relationships between individuals, and thus have potential for use in analyses when real genome data is not available.

Creating artificial human genomes using generative neural networks

Image credit: mcmurryjulie, Pixabay

02/04/2021

Research Article

The Species-Specific Acquisition and Diversification of a K1-like Family of Killer Toxins in Budding Yeasts of the Saccharomycotina

Fredericks et al. identify a new dsRNA-encoded killer toxin produced by Saccharomyces yeasts. The toxin is part of a larger family of DNA-encoded “K1 killer toxin-like” genes in more distantly related yeasts, which suggests the transfer of these genes between different yeast species that inhabit similar natural and artificial environments.

The Species-Specific Acquisition and Diversification of a K1-like Family of Killer Toxins in Budding Yeasts of the Saccharomycotina

Image credit: Fredericks et al., pgen.1009341

02/04/2021

Research Article

Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder

Huang et al. present a new statistical framework for risk gene mapping, TITANS, which integrates transmission disequilibrium information with tissue-specific regulatory annotations of multiple linked variants to infer risk genes. They find POU3F2, a gene which encodes a key transcription factor regulating multiple autism risk genes.

Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder

Image credit: Oberholster Venita, Pixabay

03/11/2021

Review

Human genetic admixture

Korunes and Goldberg discuss recent progress in human genetic admixture studies and potential areas for future work. The Review serves as an introduction to the PLOS Genetics Human Genetic Admixture Collection.

Human genetic admixture

Image credit: Mehrjoo et al., pgen.1008385

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