Advertisement

Topic Pages Collection

This collection aims to increase the coverage of computational biology and genetics-related topics                                                  in Wikipedia by rewarding authors with a citable, PubMed-indexed version of the living document on Wikipedia.

Collection

02/13/2019

Research Article

A systematic genetic screen identifies essential factors involved in nuclear size control

Here, Cantwell and Nurse exploit the genetic tractability of fission yeast to carry out a systematic genetic screen of deleted essential genes to identify those with aberrant nuclear size phenotypes. The authors reveal 25 novel genes that influence nuclear size, and bioinformatic analysis implicates both RNA processing and protein complexes in connecting nuclear chromatin to the cytoskeleton in nuclear size control.

Image credit: Cantwell and Nurse

A systematic genetic screen identifies essential factors involved in nuclear size control

Recently Published Articles

Current Issue

Current Issue January 2019

02/14/2019

Research Article

Epigenetic inheritance of telomere length in wild birds

Using longitudinal data of free-living jackdaws, Corvus monedula, Christina Bauch and colleagues show that erythrocyte telomere length (TL) of subsequent offspring decreases with parental age within individual fathers, but not mothers. By cross-fostering eggs, the authors confirm the paternal age effect to be independent of paternal age dependent care.

Image credit: Christina Bauch and colleagues

Epigenetic inheritance of telomere length in wild birds

02/01/2019

Research Article

Transcription-driven Chromatin repression of Intragenic transcription start sites

Here, Nielsen, Ard, Leng, Ivanov and colleagues characterize how transcription initiation from an upstream promoter represses alternative downstream promoter activity in plants. The authors find that this repression mechanism is associated with chromatin changes that are required to maintain precise gene expression control.

Transcription-driven Chromatin repression of Intragenic transcription start sites

Image credit: Nielsen, Ard, Leng, Ivanov and colleagues

02/04/2019

Research Article

Genomic insights into neonicotinoid sensitivity in the solitary bee Osmia bicornis

In this study, Beadle, Singh et al show that the genome of the solitary bee, Osmia bicornis, lacks the subfamily of cytochrome P450 enzymes that break down certain neonicotinoids in eusocial bees. Despite this, O. bicornis exhibits marked tolerance to the neonicotinoid thiacloprid as a result of efficient metabolism by a P450 enzyme from a different subfamily. 

Genomic insights into neonicotinoid sensitivity in the solitary bee Osmia bicornis

Image credit: Gail Hampshire, Flickr, CC-BY 2.0

02/01/2019

Research Article

Molecular predictors of brain metastasis-related microRNAs in lung adenocarcinoma

Here, Sun, Ding, Bi et al identify the key miRNAs involved in brain metastasis (BM) lung cancer. The authors identify a panel of miRNAs that distinguish BM lung adenocarcinomas from non-BM, and report that either miR-4270 downregulation or miR-423-3p upregulation significantly increases cell proliferation, colony formation, and migration in vitro

Molecular predictors of brain metastasis-related microRNAs in lung adenocarcinoma

Image credit: Guogui Sun, Xiao Ding, Nan Bi and colleagues

02/14/2019

Perspective

Evolution as a guide for experimental cell biology

Colgren & Nichols comment on work by Raza et al who demonstrate that components of the adherens junction share an evolutionary history, proving evolutionary conversion rate analysis is a powerful method of identifying novel components of cell adhesion complexes in Drosophila.

Evolution as a guide for experimental cell biology

Image credit: Colgren and Nichols

Get new content from PLOS Genetics in your inbox

Thank you! You have successfully subscribed to the PLOS Genetics newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

Try again