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Synaptonemal Complex dimerization regulates chromosome alignment and crossover patterning in meiosis

March 17, 2021

Synaptonemal Complex dimerization regulates chromosome alignment and crossover patterning in meiosis

Nuclei in meiotic prophase of a C. elegans gonad; meiosis progresses from left to right. Nuclei are immunostained for markers of genetic exchanges (GFP::COSA-1, green), foci of ongoing DNA repair (RAD-51, red), and the structural backbone of meiotic chromosomes (HTP-3, blue).

Image credit: Spencer Gordon

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Current Issue April 2021

03/19/2021

Research Article

The haplolethality paradox of the wupA gene in Drosophila

Casas-Tintó and Ferrús study the haplolethal region of the Troponin I (TnI) encoding gene wupA in Drosophila and find that haplolethality results from the combined haploinsufficiency of a large set of TnI isoforms. These findings compare to another studiedhaplolethal region and reveal a scenario of strict dosage dependence with implications for gene expression regulation and splitting.

Image credit: Casas-Tintó and Ferrús, pgen.1009108

The haplolethality paradox of the wupA gene in Drosophila

03/18/2021

Research Article

Gene disruption by structural mutations drives selection in US rice breeding over the last century

Vaughn et al. characterize and track the entire mutational spectrum between two rice varieties through the last century of rice breeding. They show that large structural mutations in exons are selected against at a greater rate than any other mutational class, which illuminates the nature of deleterious alleles and will guide attempts to predict variety vigor based solely on genomic information.

Image credit: wilkoszenator, Pixabay

Gene disruption by structural mutations drives selection in US rice breeding over the last century

03/17/2021

Research Article

Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes

Liu et al. study models of Huntington’s disease, Parkinson’s disease and Alzheimer’s disease to find that WDR81 promotes the autophagic clearance of protein aggregates via facilitating the recruitment of autophagic proteins onto protein aggregates, and reduction of WDR81 impairs the viability of mouse primary neurons.

Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes

Image credit: Liu et al., pgen.1009415

03/08/2021

Research Article

miRNA-mediated loss of m6A increases nascent translation in glioblastoma

Zepecki et al. discover the relationship between miRNAs and the RNA methylation machinery in human glioblastoma and show how miRNA-induced loss of m6A results in increase in protein translation of clinically important transcripts during glioblastoma stem cell differentiation, which has implications for the design of cancer therapeutics.

miRNA-mediated loss of m6A increases nascent translation in glioblastoma

Image credit: Zepecki et al., pgen.1009086

03/09/2021

Research Article

Polyploidy-associated paramutation in Arabidopsis is determined by small RNAs, temperature, and allele structure

Bente et al. study paramutation in Arabidopsis thaliana and find several parameters that influence paramutation: an important role for sRNAs to initiate silencing, the sequence of the allele itself, the environmental conditions during growth of the hybrids, the developmental stage, and the copy number ratio between the alleles.

Polyploidy-associated paramutation in Arabidopsis is determined by small RNAs, temperature, and allele structure

Image credit: Bente et al., pgen.1009444

04/22/2021

Perspective

Putting the brakes on centromere drive in Mimulus

Chang and Malik highlight a new study (pgen.1009418) showing an active co-evolutionary arms race between DNA and protein components of the meiotic machinery in Mimulus, with consequences for individual fitness and molecular divergence.

Putting the brakes on centromere drive in Mimulus

Image credit: Finseth et al., pgen.1009418

03/11/2021

Review

Human genetic admixture

Korunes and Goldberg discuss recent progress in human genetic admixture studies and potential areas for future work. The Review serves as an introduction to the PLOS Genetics Human Genetic Admixture Collection.

Human genetic admixture

Image credit: Mehrjoo et al., pgen.1008385

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