Advertisement
An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease

March 19, 2019

An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease

Image credit: Tomas Bergström

PLOS Genetics 2018 Reviewer and Editorial Board Thank You

PLOS and the PLOS Genetics team want to sincerely thank all of our Editorial Board Members,                                                                        Guest Editors and Reviewers for the journal in 2018.

Thank You!

03/20/2019

Research Article

Dynamic transcriptome profiles within spermatogonial and spermatocyte populations during postnatal testis maturation revealed by single-cell sequencing

Using a combination of comprehensive germ cell sampling with single-cell-mRNA-sequencing, Grive et al generate a reference dataset of germ cell gene expression. The authors show that discrete developmental stages of spermatogenesis possess significant differences in the transcriptional profiles from neonates compared to juveniles and adults.

Image credit: Kathryn J. Grive and colleagues

Dynamic transcriptome profiles within spermatogonial and spermatocyte populations during postnatal testis maturation revealed by single-cell sequencing

Recently Published Articles

See all articles
Current Issue

Current Issue February 2019

03/20/2019

Research Article

Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment

Here, Ding, Shunkwiler et al describe that deletion of the Cdkn1b gene, encoding the p27 cyclin-dependent kinase inhibitor in the estrogen-induced mammary tumor-susceptible ACI rat strain, leads to a decrease in the relative frequencies of Cd49b+ mammary luminal epithelial progenitors and pregnancy-related differentiation. 

Image credit: Ding, Shunkwiler and colleagues

Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment

03/18/2019

Research Article

Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans

Eukaryotic striatin forms striatin-interacting phosphatase and kinase (STRIPAK) complexes that control many cellular processes, however, they remain poorly understood. Here, Elramli, Karahoda et al discover six striatin (StrA) interacting proteins (Sips) which form a heptameric complex in the filamentous fungus Aspergillus nidulans.

Image credit: Elramli, Karahoda and colleagues

Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans

03/11/2019

Research Article

Rewired cellular signaling coordinates sugar and hypoxic responses for anaerobic xylose fermentation in yeast

In this study, Myers et al use comparative systems biology across strains of yeast with progressive improvements in xylose utilization to understand the metabolic and regulatory logic of anaerobic xylose fermentation, and find that mutations in evolved strains trigger signaling pathways that are normally antagonistic.

Rewired cellular signaling coordinates sugar and hypoxic responses for anaerobic xylose fermentation in yeast

Image credit: Kevin S. Myers and colleagues

03/14/2019

Viewpoints

Collateral damage and CRISPR genome editing

Mark Thomas and colleagues discuss recent findings on unwanted collateral damage caused by CRISPR-Cas systems and describe best-practice to reduce the risk of unwanted CRISPR damage when using these systems.

Collateral damage and CRISPR genome editing

Image credit: Duncan Hull, Flickr, CC BY

02/28/2019

Opinion Piece

Outside in

Front Section Editor Jonathan Flint introduces our new article type, Opinion Pieces, with a piece discussing the merits of using an "outside-in" approach to identify the biological mechanisms underlying behaviour. 

Outside in

Image credit: Vodeck, Flickr, CC0

Get new content from PLOS Genetics in your inbox

Thank you! You have successfully subscribed to the PLOS Genetics newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

Try again