03/28/2025
research article
In this study, the authors explore how different mutation rates affect the speed at which Escherichia coli bacteria develop antibiotic resistance. Their findings help explain why some bacteria rapidly develop drug resistance while others struggle, providing valuable insights into antibiotic resistance.
Image credit: pgen.1011627
Current Issue February 2025
03/31/2025
research article
In this study, the authors trace the origins of de novo mutations in child-parent trios using combined genomic analyses. They focus on identifying germline mosaicism, where a fraction of the child’s mutation is detectable in parental blood or sperm.
Image credit: pgen.1011651
03/10/2025
research article
In this study, the authors present a unique haplotype-based approach considering mother-child pairs as a single analytical unit with maternal transmitted (m1), maternal non-transmitted (m2), and paternal transmitted (p1) haplotypes.
Image credit: pgen.1011575
03/31/2025
Research article
Here the authors combine human genetic datasets spanning common and rare diseases with a database of side effects that are noted on approved drug labels. They find that overall side effects are twice as likely to occur if they are similar to a trait where the drug target gene has a genetic association.
Image credit: pgen.1011638
03/18/2025
research article
Here, the authors assess the evolutionary characteristics of canonical circadian genes across mammalian phylogeny and find genetic changes possibly related to the generation of unihemispheric slow-wave sleep.
Image credit: pgen.1011598
04/01/2025
research article
In this study, the authors engineer a chimeric protein, Rfa1-MN, which fuses the largest subunit of the single-stranded DNA-binding complex RPA with micrococcal nuclease (MN). This chimera preferentially generates DSBs at replication forks, enabling the authors to screen for mutants impaired in fork repair.
Image credit: pgen.1011405
03/31/2025
research article
The authors propose a computationally efficient method to address false-positive rates in TWAS for animal models with high relatedness and find shared biology between humans and rats.
Image credit: pgen.1011583
03/31/2025
research article
In this study, the authors perform large-scale compound screening in C. elegans, using the dual-fluorescent splicing reporter system to identify drugs that can rescue age-associated AS defects and extend lifespan.
Image credit: pgen.1011648
03/31/2025
research article
In this study, the authors develop patient-specific prostate cancer assembloids by three-dimensionally reconstituting patient-derived tumor organoids with cancer-associated fibroblasts.
Image credit: pgen.1011652
03/28/2025
Research article
In this study, the authors use a genetic tool called CRISPR interference to study genes essential for A. baumannii survival and how they interact with different antibiotics and other chemicals.
Image credit: pgen.1011642
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