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Read the full Collection of Topic Pages published in PLOS Genetics.

Collection

07/22/2022

Research Article

Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer

Scales et al. investigate the role of Hedgehog signaling in fibroblasts, a central cell type in the pancreatic tumor microenvironment. They find that Gli genes are expressed in pancreatic fibroblasts and that the proteins encoded by these genes impact pancreatic tumor growth and directly control immune cell migration.

Image credit: Michael Scales

Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer

Recently Published Articles

Current Issue

Current Issue August 2022

07/25/2022

Research Article

Motor defects in a Drosophila model for spinal muscular atrophy result from SMN depletion during early neurogenesis

Grice and Liu's in-vivo study is the first to directly rescue the motor defects of a spinal muscular atrophy model by expressing Smn in an identifiable population of Drosophila neuroblasts and developing neurons, highlighting that neuronal sensitivity to SMN loss may arise before synapse establishment and nerve cell maturation.

Image credit: pgen.1010325

Motor defects in a Drosophila model for spinal muscular atrophy result from SMN depletion during early neurogenesis

02/14/2022

Editorial

Expanding human variation at PLOS Genetics

The former Natural Variation section at PLOS Genetics relaunches as Human Genetic Variation and Disease. Read the editors' reasoning behind this change.

Expanding human variation at PLOS Genetics

Image credit: Barsh et al., pgen.1010070

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PLOS Genetics | ISSN: 1553-7404 (online)