September 10, 2020

Genetic analysis of the modern Australian labradoodle dog breed reveals an excess of the poodle genome

A new study by Muhammad Basil Ali and colleagues shows that, genetically, the Australian labradoodle designer dog breed - developed from a cross of poodles and Labrador retrievers - is primarily poodle.

Image credit: proconsult, Pixabay

Topic Pages

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08/31/2020

Research Article

Sequential activation of Notch and Grainyhead gives apoptotic competence to Abdominal-B expressing larval neuroblasts in Drosophila Central nervous system

This study from Bakshi et al. highlights that Hox dependent neuroblast apoptosis in abdominal and terminal regions of Drosophila utilizes common molecular players (Hox, Grh and Notch), but seems to have evolved different molecular strategies to pattern the developing central nervous system.

Image credit: journal.pgen.1008976.g005

Sequential activation of Notch and Grainyhead gives apoptotic competence to Abdominal-B expressing larval neuroblasts in Drosophila Central nervous system

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Current Issue August 2020

09/04/2020

Research Article

Excess crossovers impede faithful meiotic chromosome segregation in C. elegans

In this study, Hollis and colleagues find that increasing crossover number during meiosis negatively impacts chromosome segregation by altering chromosome-associated structures, leading to misalignment of the chromosomes on the meiotic spindle. Their results highlight the importance of limiting crossover numbers to enable faithful chromosome segregation during sperm and egg development.

Image credit: journal.pgen.1009001.g003

Excess crossovers impede faithful meiotic chromosome segregation in C. elegans

08/31/2020

Research Article

Serotonergic modulation of visual neurons in Drosophila melanogaster

In this work, Sampson and colleagues have found serotonin receptors expressed in all neuropils of the Drosophila melanogaster optic lobe and identified specific neurons involved in visual information processing that express serotonin receptors. Their data support a role for the serotonergic neuromodulation of interneurons in the Drosophila visual system.

Image credit: journal.pgen.1009003.g001

Serotonergic modulation of visual neurons in Drosophila melanogaster

08/06/2020

Research Article

Mapping gene flow between ancient hominins through demography-aware inference of the ancestral recombination graph

Using ARGweaver-D, Hubisz et al identify 3% of the Neanderthal genome which is likely derived from gene flow from ancient humans, and 1% of the Denisovan genome that may be traced to an unsequenced archaic hominin.

Image credit: Hubisz and colleagues

07/27/2020

Research Article

The evolution and functional divergence of the histone H2B family in plants

Jiang, Borg and colleagues report a systematic analysis of the histone H2B family in plants. The authors identify a new class of highly divergent H2B variants, H2B.S, that specifically accumulate during chromatin compaction of dry seed embryos in multiple species of flowering plants.

Image credit: Jiang, Borg and colleagues

07/30/2020

Research Article

Introns mediate post-transcriptional enhancement of nuclear gene expression in the green microalga Chlamydomonas reinhardtii

Baier et al characterize the dynamics of 33 endogenous and 13 non-native introns in C. reinhardtii, and their effect on gene expression as artificial insertions into codon optimized transgenes. They find that introns from different origins have the capacity to increase gene expression rates.

Image credit: Thomas Baier and colleagues

07/30/2020

Topic Page

Holocentric chromosomes

Mauro Mandrioli and Gian Carlo Manicardi discuss existing research on holocentric chromosomes, which possess multiple kinetochores along their length rather than the single centromere typical of other chromosomes. This article was also published as a live article on Wikipedia.

Image credit: Mandrioli and Manicardi

07/23/2020

Review

Advances and challenges in genetic technologies to produce single-sex litters

Douglas and Turner review some of the historical nongenetic strategies employed to generate single-sex litters and investigate how genetic and genome editing techniques are currently being used to produce all-male or all-female progeny.

Image credit: Elsemargriet, Pixabay, CC0

07/16/2020

Review

Double-edged sword: The evolutionary consequences of the epigenetic silencing of transposable elements

Choi and Lee provide an overview of genome-wide evidence for the presence and prevalence of TEs’ epigenetic effects, highlighting similarities and differences across mammals, insects, and plants.

Image credit: Choi and Lee

07/15/2020

Editorial

Mixed methods

Editors in Chief Gregory Barsh and Gregory Copenhaver and newly appointed Section Editors David Balding and Chengqi Yi announce the new PLOS Genetics Methods section.

Image credit: Rube Goldberg, Wikimedia Commons, CC0

Across PLOS

PLOS Open Source Toolkit

This new channel provides a global forum for open source hardware and software research and applications.
PLOS Topic Pages Collection

A new addition to PLOS Topic Pages Collection. Read Maria E. Sousa and Michael H. Farkas published PLOS Genetics Topic Page on Micropeptides.
Channel Your Community’s Research

PLOS launches a new platform that lets research communities drive content priorities. Read the blog announcement here.
PLOS Biology

Sylvain Alem and colleagues investigate the social learning of string-pulling in the bumblebee which is illustrated through a number of videos.
Epidemiological metrics for the HIV epidemic

This PLOS Medicine Special Collection reviews metrics to understand progress in diverse HIV epidemics

What's happening at PLOS Genetics?

National Academy of Sciences Elects New Members

Congratulations to PLOS Genetics Associate Editor Lorraine Symington for being elected a member of the National Academy of Sciences!
Newly elected AAAS Fellows

Congratulations to PLOS Genetics Associate Editors Harmit Malik and Cédric Feschotte for being elected Fellows of the American Association for the Advancement of Science!
Wikipedia-integrated publishing: a comparison of successful models

Read Topic Pages Editor Thomas Shafee's article discussing how PLOS and others are building bridges between Wikipedia and the broader knowledge ecosystem.
Newly elected SMBE officers and councilors

Congratulations to PLOS Genetics Editorial Board members Harmit Malik and Nadia Singh, who are SMBE President-elect and Secretary-elect respectively!
US National Academy of Sciences elects new members

Congratulations to newly-elected PLOS Genetics Editorial Board Members Sue Jinks-Robertson and Harmit Malik!

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