September 2013

The emergence of the Middle East respiratory syndrome (MERS) coronavirus, ten years after the emergence of SARS coronavirus, demonstrates the importance of understanding the biology and pathogenesis of these viruses. This knowledge will aid in the development of countermeasure against these and other potentially emergent zoonotic coronaviruses. See Coleman, Frieman.

Image Credit: Richie Frieman

Pearls

Memory of Infections: An Emerging Role for Natural Killer Cells

Alexander Rölle, Julia Pollmann, Adelheid Cerwenka

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003548

Emerging and Emerged Pathogenic Candida Species: Beyond the Candida albicans Paradigm

Nicolas Papon, Vincent Courdavault, Marc Clastre, Richard J. Bennett

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003550

Cross-Seeding of Misfolded Proteins: Implications for Etiology and Pathogenesis of Protein Misfolding Diseases

Rodrigo Morales, Ines Moreno-Gonzalez, Claudio Soto

PLOS Pathogens: published September 19, 2013 | https://doi.org/10.1371/journal.ppat.1003537

Self and Non-self Discrimination of Intracellular Membranes by the Innate Immune System

Jörn Coers

PLOS Pathogens: published September 19, 2013 | https://doi.org/10.1371/journal.ppat.1003538

Innate Immune Sensing of Flaviviruses

Mehul S. Suthar, Sebastian Aguirre, Ana Fernandez-Sesma

PLOS Pathogens: published September 12, 2013 | https://doi.org/10.1371/journal.ppat.1003541

Death Be Not Proud—Cell Death Control in Plant Fungal Interactions

Martin B. Dickman, Paul de Figueiredo

PLOS Pathogens: published September 12, 2013 | https://doi.org/10.1371/journal.ppat.1003542

Atomic Force Microscopy: A New Look at Pathogens

David Alsteens, Audrey Beaussart, Sofiane El-Kirat-Chatel, Ruby May A. Sullan, Yves F. Dufrêne

PLOS Pathogens: published September 5, 2013 | https://doi.org/10.1371/journal.ppat.1003516

Bringing Culture to the Uncultured: Coxiella burnetii and Lessons for Obligate Intracellular Bacterial Pathogens

Anders Omsland, Ted Hackstadt, Robert A. Heinzen

PLOS Pathogens: published September 5, 2013 | https://doi.org/10.1371/journal.ppat.1003540

Emergence of the Middle East Respiratory Syndrome Coronavirus

Christopher M. Coleman, Matthew B. Frieman

PLOS Pathogens: published September 5, 2013 | https://doi.org/10.1371/journal.ppat.1003595

Research Articles

Highly Significant Antiviral Activity of HIV-1 LTR-Specific Tre-Recombinase in Humanized Mice

Ilona Hauber, Helga Hofmann-Sieber, Jan Chemnitz, Danilo Dubrau, Janet Chusainow, Rolf Stucka, Philip Hartjen, Axel Schambach, Patrick Ziegler, Karl Hackmann, Evelin Schröck, Udo Schumacher, Christoph Lindner, Adam Grundhoff, Christopher Baum, Markus G. Manz, Frank Buchholz, Joachim Hauber

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003587

Sustained Autophagy Contributes to Measles Virus Infectivity

Clémence Richetta, Isabel P. Grégoire, Pauline Verlhac, Olga Azocar, Joël Baguet, Monique Flacher, Frédéric Tangy, Chantal Rabourdin-Combe, Mathias Faure

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003599

Host Adaptation Is Contingent upon the Infection Route Taken by Pathogens

Nelson E. Martins, Vitor G. Faria, Luis Teixeira, Sara Magalhães, Élio Sucena

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003601

Dual Analysis of the Murine Cytomegalovirus and Host Cell Transcriptomes Reveal New Aspects of the Virus-Host Cell Interface

Vanda Juranic Lisnic, Marina Babic Cac, Berislav Lisnic, Tihana Trsan, Adam Mefferd, Chitrangada Das Mukhopadhyay, Charles H. Cook, Stipan Jonjic, Joanne Trgovcich

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003611

Atomic Resolution Description of the Interaction between the Nucleoprotein and Phosphoprotein of Hendra Virus

Guillaume Communie, Johnny Habchi, Filip Yabukarski, David Blocquel, Robert Schneider, Nicolas Tarbouriech, Nicolas Papageorgiou, Rob W. H. Ruigrok, Marc Jamin, Malene Ringkjøbing Jensen, Sonia Longhi, Martin Blackledge

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003631

Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10

Kathryn A. K. Finton, Kevin Larimore, H. Benjamin Larman, Della Friend, Colin Correnti, Peter B. Rupert, Stephen J. Elledge, Philip D. Greenberg, Roland K. Strong

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003639

Inherited Prion Disease A117V Is Not Simply a Proteinopathy but Produces Prions Transmissible to Transgenic Mice Expressing Homologous Prion Protein

Emmanuel A. Asante, Jacqueline M. Linehan, Michelle Smidak, Andrew Tomlinson, Andrew Grimshaw, Asif Jeelani, Tatiana Jakubcova, Shyma Hamdan, Caroline Powell, Sebastian Brandner, Jonathan D. F. Wadsworth, John Collinge

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003643

Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

Martin Marek, Srinivasaraghavan Kannan, Alexander-Thomas Hauser, Marina Moraes Mourão, Stéphanie Caby, Vincent Cura, Diana A. Stolfa, Karin Schmidtkunz, Julien Lancelot, Luiza Andrade, Jean-Paul Renaud, Guilherme Oliveira, Wolfgang Sippl, Manfred Jung, Jean Cavarelli, Raymond J. Pierce, Christophe Romier

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003645

Absence of Siglec-H in MCMV Infection Elevates Interferon Alpha Production but Does Not Enhance Viral Clearance

Franz Puttur, Catharina Arnold-Schrauf, Katharina Lahl, Gulhas Solmaz, Marc Lindenberg, Christian Thomas Mayer, Melanie Gohmert, Maxine Swallow, Christopher van Helt, Heike Schmitt, Lars Nitschke, Bart N. Lambrecht, Roland Lang, Martin Messerle, Tim Sparwasser

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003648

A New Class of Quorum Quenching Molecules from Staphylococcus Species Affects Communication and Growth of Gram-Negative Bacteria

Ya-Yun Chu, Mulugeta Nega, Martina Wölfle, Laure Plener, Stephanie Grond, Kirsten Jung, Friedrich Götz

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003654

The Suf Iron-Sulfur Cluster Synthesis Pathway Is Required for Apicoplast Maintenance in Malaria Parasites

Jolyn E. Gisselberg, Teegan A. Dellibovi-Ragheb, Krista A. Matthews, Gundula Bosch, Sean T. Prigge

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003655

Assisted Evolution Enables HIV-1 to Overcome a High TRIM5α-Imposed Genetic Barrier to Rhesus Macaque Tropism

Steven J. Soll, Sam J. Wilson, Sebla B. Kutluay, Theodora Hatziioannou, Paul D. Bieniasz

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003667

Cross-Serotype Immunity Induced by Immunization with a Conserved Rhinovirus Capsid Protein

Nicholas Glanville, Gary R. Mclean, Bruno Guy, Valerie Lecouturier, Catherine Berry, Yves Girerd, Christophe Gregoire, Ross P. Walton, Rebecca M. Pearson, Tatiana Kebadze, Nicolas Burdin, Nathan W. Bartlett, Jeffrey W. Almond, Sebastian L. Johnston

PLOS Pathogens: published September 26, 2013 | https://doi.org/10.1371/journal.ppat.1003669

Lymph Node Colonization Dynamics after Oral Salmonella Typhimurium Infection in Mice

Patrick Kaiser, Emma Slack, Andrew J. Grant, Wolf-Dietrich Hardt, Roland R. Regoes

PLOS Pathogens: published September 19, 2013 | https://doi.org/10.1371/journal.ppat.1003532

Phosphoproteomic Analyses Reveal Signaling Pathways That Facilitate Lytic Gammaherpesvirus Replication

James A. Stahl, Shweta S. Chavan, Jeffrey M. Sifford, Veronica MacLeod, Daniel E. Voth, Ricky D. Edmondson, J. Craig Forrest

PLOS Pathogens: published September 19, 2013 | https://doi.org/10.1371/journal.ppat.1003583

Activation of Ran GTPase by a Legionella Effector Promotes Microtubule Polymerization, Pathogen Vacuole Motility and Infection

Eva Rothmeier, Gudrun Pfaffinger, Christine Hoffmann, Christopher F. Harrison, Heinrich Grabmayr, Urska Repnik, Mandy Hannemann, Stefan Wölke, Andreas Bausch, Gareth Griffiths, Annette Müller-Taubenberger, Aymelt Itzen, Hubert Hilbi

PLOS Pathogens: published September 19, 2013 | https://doi.org/10.1371/journal.ppat.1003598

Vesicular Transport of Progeny Parvovirus Particles through ER and Golgi Regulates Maturation and Cytolysis

Séverine Bär, Jean Rommelaere, Jürg P. F. Nüesch

PLOS Pathogens: published September 19, 2013 | https://doi.org/10.1371/journal.ppat.1003605

Group 2 Innate Lymphoid Cell Production of IL-5 Is Regulated by NKT Cells during Influenza Virus Infection

Stacey Ann Gorski, Young S. Hahn, Thomas J. Braciale

PLOS Pathogens: published September 19, 2013 | https://doi.org/10.1371/journal.ppat.1003615

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

Rogier W. Sanders, Ronald Derking, Albert Cupo, Jean-Philippe Julien, Anila Yasmeen, Natalia de Val, Helen J. Kim, Claudia Blattner, Alba Torrents de la Peña, Jacob Korzun, Michael Golabek, Kevin de los Reyes, Thomas J. Ketas, Marit J. van Gils, C. Richter King, Ian A. Wilson, Andrew B. Ward, P. J. Klasse, John P. Moore

PLOS Pathogens: published September 19, 2013 | https://doi.org/10.1371/journal.ppat.1003618

Epstein Barr Virus-Induced 3 (EBI3) Together with IL-12 Negatively Regulates T Helper 17-Mediated Immunity to Listeria monocytogenes Infection

Yeonseok Chung, Tomohide Yamazaki, Byung-Seok Kim, Yongliang Zhang, Joseph M. Reynolds, Gustavo J. Martinez, Seon Hee Chang, Hoyong Lim, Mark Birkenbach, Chen Dong

PLOS Pathogens: published September 19, 2013 | https://doi.org/10.1371/journal.ppat.1003628

HTLV-1 bZIP Factor Induces Inflammation through Labile Foxp3 Expression

Nanae Yamamoto-Taguchi, Yorifumi Satou, Paola Miyazato, Koichi Ohshima, Masanori Nakagawa, Koko Katagiri, Tatsuo Kinashi, Masao Matsuoka

PLOS Pathogens: published September 19, 2013 | https://doi.org/10.1371/journal.ppat.1003630

Inactivation of Intergenic Enhancers by EBNA3A Initiates and Maintains Polycomb Signatures across a Chromatin Domain Encoding CXCL10 and CXCL9

Marie L. Harth-Hertle, Barbara A. Scholz, Florian Erhard, Laura V. Glaser, Lars Dölken, Ralf Zimmer, Bettina Kempkes

PLOS Pathogens: published September 19, 2013 | https://doi.org/10.1371/journal.ppat.1003638

Acute Neonatal Infections ‘Lock-In’ a Suboptimal CD8+ T Cell Repertoire with Impaired Recall Responses

Brian D. Rudd, Vanessa Venturi, Norah L. Smith, Kito Nzingha, Emily L. Goldberg, Gang Li, Janko Nikolich-Zugich, Miles P. Davenport

PLOS Pathogens: published September 12, 2013 | https://doi.org/10.1371/journal.ppat.1003572

Aggressive Chemotherapy and the Selection of Drug Resistant Pathogens

Silvie Huijben, Andrew S. Bell, Derek G. Sim, Danielle Tomasello, Nicole Mideo, Troy Day, Andrew F. Read

PLOS Pathogens: published September 12, 2013 | https://doi.org/10.1371/journal.ppat.1003578

Methionine Biosynthesis in Staphylococcus aureus Is Tightly Controlled by a Hierarchical Network Involving an Initiator tRNA-Specific T-box Riboswitch

Sonja M. K. Schoenfelder, Gabriella Marincola, Tobias Geiger, Christiane Goerke, Christiane Wolz, Wilma Ziebuhr

PLOS Pathogens: published September 12, 2013 | https://doi.org/10.1371/journal.ppat.1003606

Rapid Sequential Spread of Two Wolbachia Variants in Drosophila simulans

Peter Kriesner, Ary A. Hoffmann, Siu F. Lee, Michael Turelli, Andrew R. Weeks

PLOS Pathogens: published September 12, 2013 | https://doi.org/10.1371/journal.ppat.1003607

Human Cytomegalovirus Gene UL76 Induces IL-8 Expression through Activation of the DNA Damage Response

Helena Costa, Rute Nascimento, John Sinclair, Robert Michael Evans Parkhouse

PLOS Pathogens: published September 12, 2013 | https://doi.org/10.1371/journal.ppat.1003609

Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes

Fei Liu, Matthew Campagna, Yonghe Qi, Xuesen Zhao, Fang Guo, Chunxiao Xu, Sichen Li, Wenhui Li, Timothy M. Block, Jinhong Chang, Ju-Tao Guo

PLOS Pathogens: published September 12, 2013 | https://doi.org/10.1371/journal.ppat.1003613

The Crystal Structure and RNA-Binding of an Orthomyxovirus Nucleoprotein

Wenjie Zheng, John Olson, Vikram Vakharia, Yizhi Jane Tao

PLOS Pathogens: published September 12, 2013 | https://doi.org/10.1371/journal.ppat.1003624

Small RNA sX13: A Multifaceted Regulator of Virulence in the Plant Pathogen Xanthomonas

Cornelius Schmidtke, Ulrike Abendroth, Juliane Brock, Javier Serrania, Anke Becker, Ulla Bonas

PLOS Pathogens: published September 12, 2013 | https://doi.org/10.1371/journal.ppat.1003626

Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)

Katarzyna J. Maresz, Annelie Hellvard, Aneta Sroka, Karina Adamowicz, Ewa Bielecka, Joanna Koziel, Katarzyna Gawron, Danuta Mizgalska, Katarzyna A. Marcinska, Malgorzata Benedyk, Krzysztof Pyrc, Anne-Marie Quirke, Roland Jonsson, Saba Alzabin, Patrick J. Venables, Ky-Anh Nguyen, Piotr Mydel, Jan Potempa

PLOS Pathogens: published September 12, 2013 | https://doi.org/10.1371/journal.ppat.1003627

Modulation of Enhancer Looping and Differential Gene Targeting by Epstein-Barr Virus Transcription Factors Directs Cellular Reprogramming

Michael J. McClellan, C. David Wood, Opeoluwa Ojeniyi, Tim J. Cooper, Aditi Kanhere, Aaron Arvey, Helen M. Webb, Richard D. Palermo, Marie L. Harth-Hertle, Bettina Kempkes, Richard G. Jenner, Michelle J. West

PLOS Pathogens: published September 12, 2013 | https://doi.org/10.1371/journal.ppat.1003636

Genome-Wide Mouse Mutagenesis Reveals CD45-Mediated T Cell Function as Critical in Protective Immunity to HSV-1

Grégory Caignard, Gabriel A. Leiva-Torres, Michael Leney-Greene, Benoit Charbonneau, Anne Dumaine, Nassima Fodil-Cornu, Michal Pyzik, Pablo Cingolani, Jeremy Schwartzentruber, Jeremy Dupaul-Chicoine, Huaijian Guo, Maya Saleh, André Veillette, Marc Lathrop, Mathieu Blanchette, Jacek Majewski, Angela Pearson, Silvia M. Vidal

PLOS Pathogens: published September 12, 2013 | https://doi.org/10.1371/journal.ppat.1003637

A Comprehensive Analysis of In Vitro and In Vivo Genetic Fitness of Pseudomonas aeruginosa Using High-Throughput Sequencing of Transposon Libraries

David Skurnik, Damien Roux, Hugues Aschard, Vincent Cattoir, Deborah Yoder-Himes, Stephen Lory, Gerald B. Pier

PLOS Pathogens: published September 5, 2013 | https://doi.org/10.1371/journal.ppat.1003582

Proteomic Screening of Human Targets of Viral microRNAs Reveals Functions Associated with Immune Evasion and Angiogenesis

Amelia M. Gallaher, Sudipto Das, Zhen Xiao, Thorkell Andresson, Philippe Kieffer-Kwon, Christine Happel, Joseph Ziegelbauer

PLOS Pathogens: published September 5, 2013 | https://doi.org/10.1371/journal.ppat.1003584

Viral Membrane Fusion and Nucleocapsid Delivery into the Cytoplasm are Distinct Events in Some Flaviviruses

Adel M. Nour, Yue Li, Joseph Wolenski, Yorgo Modis

PLOS Pathogens: published September 5, 2013 | https://doi.org/10.1371/journal.ppat.1003585

The Zebrafish as a New Model for the In Vivo Study of Shigella flexneri Interaction with Phagocytes and Bacterial Autophagy

Serge Mostowy, Laurent Boucontet, Maria J. Mazon Moya, Andrea Sirianni, Pierre Boudinot, Michael Hollinshead, Pascale Cossart, Philippe Herbomel, Jean-Pierre Levraud, Emma Colucci-Guyon

PLOS Pathogens: published September 5, 2013 | https://doi.org/10.1371/journal.ppat.1003588

Identification of Immune and Viral Correlates of Norovirus Protective Immunity through Comparative Study of Intra-Cluster Norovirus Strains

Shu Zhu, Doron Regev, Makiko Watanabe, Danielle Hickman, Nissin Moussatche, Desyree Murta Jesus, Shannon M. Kahan, Sawsan Napthine, Ian Brierley, Robert N. Hunter III, Divya Devabhaktuni, Melissa K. Jones, Stephanie M. Karst

PLOS Pathogens: published September 5, 2013 | https://doi.org/10.1371/journal.ppat.1003592

The CLIP-Domain Serine Protease Homolog SPCLIP1 Regulates Complement Recruitment to Microbial Surfaces in the Malaria Mosquito Anopheles gambiae

Michael Povelones, Lavanya Bhagavatula, Hassan Yassine, Lee Aun Tan, Leanna M. Upton, Mike A. Osta, George K. Christophides

PLOS Pathogens: published September 5, 2013 | https://doi.org/10.1371/journal.ppat.1003623

Calcineurin Plays Key Roles in the Dimorphic Transition and Virulence of the Human Pathogenic Zygomycete Mucor circinelloides

Soo Chan Lee, Alicia Li, Silvia Calo, Joseph Heitman

PLOS Pathogens: published September 5, 2013 | https://doi.org/10.1371/journal.ppat.1003625

Cover

The rise of coronaviruses

Pearls

Research Articles

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