The intracellular pathogen L. pneumophila infects eukaryotic cells and replicates in an endoplasmic reticulum-derived vacuole. Bacterial effector proteins translocated into host cells by a type IV secretion system called Dot/Icm control vacuole maturation. Regulation of distinct maturation events involves the spatial and temporal association of effector proteins with the vacuole. This image shows recruitment of the effector protein PieA (green) to vacuoles containing replicating L. pneumophila (blue rods). The authors demonstrate a unique mechanism for PieA recruitment to the mature L. pneumophila vacuole that requires protein modification to the vacuole membrane mediated by other L. pneumophila effectors (see Ninio et al., doi:10.1371/journal.ppat.1000278).
Image Credit: Shira Ninio, Yale University School of Medicine
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PLOS Pathogens: published January 30, 2009 | https://doi.org/10.1371/journal.ppat.1000267
Research Articles
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PLOS Pathogens: published January 2, 2009 | https://doi.org/10.1371/journal.ppat.1000252
Quantitative Models of In Vitro Bacteriophage–Host Dynamics and Their Application to Phage Therapy
PLOS Pathogens: published January 2, 2009 | https://doi.org/10.1371/journal.ppat.1000253
Positive Selection Results in Frequent Reversible Amino Acid Replacements in the G Protein Gene of Human Respiratory Syncytial Virus
PLOS Pathogens: published January 2, 2009 | https://doi.org/10.1371/journal.ppat.1000254
The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation
PLOS Pathogens: published January 2, 2009 | https://doi.org/10.1371/journal.ppat.1000255
An Upstream Open Reading Frame Controls Translation of var2csa, a Gene Implicated in Placental Malaria
PLOS Pathogens: published January 2, 2009 | https://doi.org/10.1371/journal.ppat.1000256
The Cell Adhesion Molecule “CAR” and Sialic Acid on Human Erythrocytes Influence Adenovirus In Vivo Biodistribution
PLOS Pathogens: published January 2, 2009 | https://doi.org/10.1371/journal.ppat.1000277
Role of Intraspecies Recombination in the Spread of Pathogenicity Islands within the Escherichia coli Species
PLOS Pathogens: published January 9, 2009 | https://doi.org/10.1371/journal.ppat.1000257
A Role for the Unfolded Protein Response (UPR) in Virulence and Antifungal Susceptibility in Aspergillus fumigatus
PLOS Pathogens: published January 9, 2009 | https://doi.org/10.1371/journal.ppat.1000258
A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75
PLOS Pathogens: published January 9, 2009 | https://doi.org/10.1371/journal.ppat.1000259
Control of Stochastic Gene Expression by Host Factors at the HIV Promoter
PLOS Pathogens: published January 9, 2009 | https://doi.org/10.1371/journal.ppat.1000260
Genomic Survey of the Non-Cultivatable Opportunistic Human Pathogen, Enterocytozoon bieneusi
PLOS Pathogens: published January 9, 2009 | https://doi.org/10.1371/journal.ppat.1000261
Distinct Roles of Plasmodium Rhomboid 1 in Parasite Development and Malaria Pathogenesis
PLOS Pathogens: published January 16, 2009 | https://doi.org/10.1371/journal.ppat.1000262
miR-198 Inhibits HIV-1 Gene Expression and Replication in Monocytes and Its Mechanism of Action Appears To Involve Repression of Cyclin T1
PLOS Pathogens: published January 16, 2009 | https://doi.org/10.1371/journal.ppat.1000263
Imbalanced Lignin Biosynthesis Promotes the Sexual Reproduction of Homothallic Oomycete Pathogens
PLOS Pathogens: published January 16, 2009 | https://doi.org/10.1371/journal.ppat.1000264
Malaria Parasite Invasion of the Mosquito Salivary Gland Requires Interaction between the Plasmodium TRAP and the Anopheles Saglin Proteins
PLOS Pathogens: published January 16, 2009 | https://doi.org/10.1371/journal.ppat.1000265
Parasitic Nematodes Modulate PIN-Mediated Auxin Transport to Facilitate Infection
PLOS Pathogens: published January 16, 2009 | https://doi.org/10.1371/journal.ppat.1000266
Gain of Function Mutations in CgPDR1 of Candida glabrata Not Only Mediate Antifungal Resistance but Also Enhance Virulence
PLOS Pathogens: published January 16, 2009 | https://doi.org/10.1371/journal.ppat.1000268
Genomic Analysis Reveals a Potential Role for Cell Cycle Perturbation in HCV-Mediated Apoptosis of Cultured Hepatocytes
PLOS Pathogens: published January 16, 2009 | https://doi.org/10.1371/journal.ppat.1000269
Rab11A-Controlled Assembly of the Inner Membrane Complex Is Required for Completion of Apicomplexan Cytokinesis
PLOS Pathogens: published January 23, 2009 | https://doi.org/10.1371/journal.ppat.1000270
The IpaC Carboxyterminal Effector Domain Mediates Src-Dependent Actin Polymerization during Shigella Invasion of Epithelial Cells
PLOS Pathogens: published January 23, 2009 | https://doi.org/10.1371/journal.ppat.1000271
Immunization with Single-Cycle SIV Significantly Reduces Viral Loads After an Intravenous Challenge with SIVmac239
PLOS Pathogens: published January 23, 2009 | https://doi.org/10.1371/journal.ppat.1000272
An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery
PLOS Pathogens: published January 23, 2009 | https://doi.org/10.1371/journal.ppat.1000273
Inflammatory Genital Infections Mitigate a Severe Genetic Bottleneck in Heterosexual Transmission of Subtype A and C HIV-1
PLOS Pathogens: published January 23, 2009 | https://doi.org/10.1371/journal.ppat.1000274
Viral Mimicry of Cdc2/Cyclin-Dependent Kinase 1 Mediates Disruption of Nuclear Lamina during Human Cytomegalovirus Nuclear Egress
PLOS Pathogens: published January 23, 2009 | https://doi.org/10.1371/journal.ppat.1000275
Trypanosome Lytic Factor, an Antimicrobial High-Density Lipoprotein, Ameliorates Leishmania Infection
PLOS Pathogens: published January 23, 2009 | https://doi.org/10.1371/journal.ppat.1000276
A Legionella pneumophila Effector Protein Encoded in a Region of Genomic Plasticity Binds to Dot/Icm-Modified Vacuoles
PLOS Pathogens: published January 23, 2009 | https://doi.org/10.1371/journal.ppat.1000278
Selective Transmission of R5 HIV-1 over X4 HIV-1 at the Dendritic Cell–T Cell Infectious Synapse Is Determined by the T Cell Activation State
PLOS Pathogens: published January 30, 2009 | https://doi.org/10.1371/journal.ppat.1000279
Rotavirus NSP1 Inhibits NFκB Activation by Inducing Proteasome-Dependent Degradation of β-TrCP: A Novel Mechanism of IFN Antagonism
PLOS Pathogens: published January 30, 2009 | https://doi.org/10.1371/journal.ppat.1000280
Estimation of Transmission Parameters of H5N1 Avian Influenza Virus in Chickens
PLOS Pathogens: published January 30, 2009 | https://doi.org/10.1371/journal.ppat.1000281
Local Inflammation Induces Complement Crosstalk Which Amplifies the Antimicrobial Response
PLOS Pathogens: published January 30, 2009 | https://doi.org/10.1371/journal.ppat.1000282
Diploids in the Cryptococcus neoformans Serotype A Population Homozygous for the α Mating Type Originate via Unisexual Mating
PLOS Pathogens: published January 30, 2009 | https://doi.org/10.1371/journal.ppat.1000283
Glutathione Provides a Source of Cysteine Essential for Intracellular Multiplication of Francisella tularensis
PLOS Pathogens: published January 30, 2009 | https://doi.org/10.1371/journal.ppat.1000284
Polar Localization of Virulence-Related Esx-1 Secretion in Mycobacteria
PLOS Pathogens: published January 30, 2009 | https://doi.org/10.1371/journal.ppat.1000285