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Current Issue February 2021

02/11/2021

Editorial

On the open-source landscape of PLOS Computational Biology

In this paper Boudreau et al. examine the open-source landscape of PLOS Computational Biology. All the articles published in PLOS Computational Biology from January to December 2019 were downloaded. A script was then executed to search for all the articles that contained one of a list of keywords that may hint at containing code/data.

Image credit: Boudreau et al. pcbi.1008725

On the open-source landscape of PLOS Computational Biology

02/01/2021

Research Article

Directed attenuation to enhance vaccine immunity

Antia et al. use models to explore ways of directing the attenuation of a virus to avoid tradeoff whereby attenuation depresses the within-host viral load and pathology (which is beneficial to vaccine design), but reduces immunity (which is not beneficial). Antia et al. show that directed attenuation by interfering with (some) viral immune-evasion pathways can yield a mild infection but elicit higher levels of immunity than of the wild-type virus.

Directed attenuation to enhance vaccine immunity

Image credit: Antia et al pcbi.1008602

11/18/2019

Featured Collection

Ten Simple Rules

"Ten Simple Rules" provide a quick, concentrated guide for mastering some of the professional challenges research scientists face in their careers.

Ten Simple Rules

Image credit: PLOS

05/05/2020

Featured Blog Post

Improving reproducibility of computational models

In this piece, we announce a pilot (now closed) to support reproducibility by offering expert technical peer review, specifically checking that submitted systems biology or physiology-based models run according to the results presented in the manuscript.

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Improving reproducibility of computational models

Image credit: PLOS.

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