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Protein ensembles link genotype to phenotype

June 20, 2019

Protein ensembles link genotype to phenotype

Image credit: Nussinov et al, pcbi.1006648.

06/17/2019

Research Article

A multi-scale model of gas transport in the lung to study heterogeneous lung ventilation during the multiple-breath washout test

Computational models help us to understand the relation between anatomical structure and physiological properties of the lung, but none of them has dealt with the multiple-breath washout (MBW) test in whole. Hasler, Anagnostopoulou et al. aimed to create a lung model that simulates the entire MBW test and study the role of lung structure and tissue mechanics on the washout procedure.

Image credit: Hasler, Anagnostopoulou et al, pcbi.1007079.

A multi-scale model of gas transport in the lung to study heterogeneous lung ventilation during the multiple-breath washout test

Recently Published Articles

Current Issue

Current Issue May 2019

06/19/2019

Research Article

Modeling metabolic networks of individual bacterial agents in heterogeneous and dynamic soil habitats (IndiMeSH)

Despite the high bacterial abundance found in fertile soil, bacteria occupy a small fraction of soil surfaces and often form hotspots with disproportionate contributions to biogenic fluxes. As soil opacity and complexity limit detailed observations of hotspots, Borer et al. developed a modeling platform to enable systematic study of dense multispecies bacterial communities within a structured habitat resembling (not limited to) soil.

Image credit: Borer et al, pcbi.1007127.

Modeling metabolic networks of individual bacterial agents in heterogeneous and dynamic soil habitats (IndiMeSH)

06/20/2019

Research Article

Coupling water fluxes with cell wall mechanics in a multicellular model of plant development

Plant cells are surrounded by a rigid wall that prevents cell displacements and rearrangements as in animal tissues. It has long been recognized that cell growth relies on the competition between osmosis that tends to attract water into the cells and wall mechanics that resist it, but this interplay has never been fully explored in a multicellular model. The goal of this work is to analyze the theoretical consequences of this coupling.

Image credit: Cheddadi et al, pcbi.1007121.

Coupling water fluxes with cell wall mechanics in a multicellular model of plant development

06/20/2019

Education Article

Ten quick tips for effective dimensionality reduction

Although many dimensionality reduction (DR) techniques have been developed and implemented in standard data analytic pipelines, they are easy to misuse, and their results are often misinterpreted in practice. This article presents a set of useful guidelines for practitioners specifying how to correctly perform DR, interpret its output, and communicate results.

Ten quick tips for effective dimensionality reduction

Image credit: Nguyen et al, pcbi.1006907.

11/30/2016

Featured Issue Image

Machine Learning of Insect Vector Feeding

Asian citrus psyllids (Diaphorina citri), pictured, feed on citrus and can transmit the pathogen causing citrus greening.

Machine Learning of Insect Vector Feeding

Image credit: Jeffrey Weston Lotz.

06/05/2019

Featured Channel

Disease Forecasting & Surveillance

New channel update featuring PLOS Computational Biology research by Drake et al. as the Editor's Pick. This update also features work from Epidemics, bioRxiv, and PLOS Neglected Tropical Diseases.

Disease Forecasting & Surveillance

Image credit: Drake et al, pcbi.1006917; foam/Flickr.

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