03/05/2021
Research Article
Inferring latent temporal progression and regulatory networks from cross-sectional transcriptomic data of cancer samples
Image credit: Sun et al. pcbi.1008379
March 3, 2021
Up-down biphasic volume response of human red blood cells to PIEZO1 activation during capillary transits
Image credit: Rogers & Lew. pcbi.1008706
Recently Published Articles
- MiMeNet: Exploring microbiome-metabolome relationships using neural networks
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- Can molecular dynamics simulations improve the structural accuracy and virtual screening performance of GPCR models?
Current Issue April 2021
03/12/2021
Research Article
Aggregation of Aβ40/42 chains in the presence of cyclic neuropeptides investigated by molecular dynamics simulations
Wu et al. use molecular dynamics simulations to look at the influence of somatostatin-14 (SST14), a cyclic neuropeptide that might be involved in the amyloidogenic aggregation of Aβ, on molecular processes occurring at the onset of Aβ aggregation. Results explain how the presence of SST14 might alter pathways of aggregation of Aβ and shed light on the possible role of extrinsic factors in the aggregation at a molecular level.
Image credit: Wu et al. pcbi.1008771
03/30/2021
Editorial (invitation only)
Collaborating with our community to increase code sharing
Given how essential newly developed code can be to computational biology research the Editorial Board of PLOS Computational Biology, in consultation with computational biology researchers, developed a new more-rigorous code policy that is intended to increase code sharing on publication of articles.
Image credit: StockSnap/ pixabay.
03/18/2021
Research Article
Connectivity, reproduction number, and mobility interact to determine communities’ epidemiological superspreader potential in a metapopulation network
Lieberthal & Gardner provide a model to predict the location of superspreader events in future epidemics and to predict the effectiveness of mitigation strategies.
Image credit: Liberthal & Gardner pcbi.1008674
03/17/2021
Research Article
SARS-CoV-2 viral dynamics in non-human primates
Gonçalves et al. used a mathematical model to characterize the viral dynamics (of SARS-CoV-2) in cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. Their results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
Image credit: Gonçalves et al. pcbi.1008785
03/11/2021
Research Article
Can subjective pain be inferred from objective physiological data? Evidence from patients with sickle cell disease
Panaggio et al. apply two machine learning approaches to data from patients with sickle cell disease, who often experience debilitating pain crises. They developed both sequential and non-sequential probabilistic models that can be used to infer pain levels or changes in pain from sequences of physiological measures.
Image credit: Panaggio et al. pcbi.1008542
11/18/2019
Featured Collection
Ten Simple Rules
"Ten Simple Rules" provide a quick, concentrated guide for mastering some of the professional challenges research scientists face in their careers.
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01/20/2020
Top Tweet
SIO Acoustic Ecology
Excited to share our latest article: DetEdit: A graphical user interface for annotating and editing events detected in long-term acoustic monitoring data, published in @ploscompbiol: journals.plos.org/ploscompbiol/a ... #ploscompbiolauthor. Try it, play with it.
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11/26/2009
Featured Issue Image
LocaNMF for region-based decomposition of neural recordings from the mouse brain
Widefield calcium imaging provides a global view of neural activity in the mouse dorsal cortex.
Image credit: Shreya Saxena (Columbia University)
05/05/2020
Featured Blog Post
Improving reproducibility of computational models
In this piece, we announce a pilot (now closed) to support reproducibility by offering expert technical peer review, specifically checking that submitted systems biology or physiology-based models run according to the results presented in the manuscript.
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Collections
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Topic Pages
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
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Developing Computational Biology
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
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Education
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
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Benchmarking
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
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PLOS Biology
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
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PLOS Neglected Tropical Diseases
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
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PLOS Pathogens
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
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PLOS Medicine
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
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