Protein–protein interactions are key to understand the molecular level mechanisms of regulation in the cell. However, there is still a limited understanding of what distinguishes a protein-protein binding site from the rest of the surface. This lack of knowledge is manifested in the relatively low accuracy of computational methods that try to predict protein interfaces. In this work, Viswanathan et al. report a new conceptual insight about protein interfaces. Their results suggest that protein interfaces serve as generic binding sites to any ligand.
Image credit: Viswanathan et al, pcbi.1006704.