Advertisement

The PLOS Computational Biology 2019 Research Prize has launched!

Nominate your favorite 2018 article!

Find out more!

03/11/2019

Research Article

Myopic control of neural dynamics

A powerful perspective for understanding a neural system’s behavior undergoing stimulation is to conceptualize them as dynamical systems, which considers the global effect that stimulation has on the brain, rather than only assessing what impact it has on the recorded signal from the brain. In this work Hocker & Park explore the implications of this new perspective on neural stimulation and derive a simple prescription for using neural observations to inform stimulation protocol that makes one neural system behave like another.

Image credit: Hocker & Park, pcbi.1006854.

Myopic control of neural dynamics

Recently Published Articles

Current Issue

Current Issue February 2019

03/12/2019

Research Article

Optimizing the depth and the direction of prospective planning using information values

When faced with several choices in complex environments like chess, thinking about all the potential consequences of each choice, deep into the future, is simply impossible due to time and cognitive limitations. Sezener et al. propose a mathematical algorithm that computes, along the course of planning, the benefit of thinking another step in a given direction into the future, and compares that with the cost of thinking in order to compute the net benefit.

Image credit: Sezener et al, pcbi.1006827.

Optimizing the depth and the direction of prospective planning using information values

03/11/2019

Research Article

Pan-cancer landscape of centrosome amplification

To exploit centrosome amplification’s clinical potential, it's crucial to understand its role in cancer development and identify compounds for selective targeting: challenging tasks due to difficulty profiling centrosome amplification in cells. de Almeida et al. bypass the challenges by analysing expression of 20 genes known to promote centrosome amplification across 10,000 tumours of 30 cancer types, thereby estimating their relative centrosome amplification levels.

Image credit: de Almeida et al, pcbi.1006832.

Pan-cancer landscape of centrosome amplification

03/11/2019

Research Article

Latent goal models for dynamic strategic interaction

Here, Iqbal, Yin et al. propose a new model that is capable of reproducing the rich behavior of monkeys playing against each other in a dynamic decision task. Their model quantifies players’ goals at each moment and offers a means of performing controlled experiments via simulation. This makes possible more realistic experimental paradigms for the study of strategic decision making and social interaction.

Latent goal models for dynamic strategic interaction

Image credit: Iqbal, Yin et al, pcbi.1006895.

03/12/2019

Research Article

Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation

Luque et al. explore the role of Purkinje spike burst-pause dynamics in VOR adaptation. A biophysical model of Purkinje cell is at the core of a spiking network model, which captures the cerebellar microcircuit properties and incorporates spike-based synaptic plasticity mechanisms at different cerebellar sites.

Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation

Image credit: Luque et al, pcbi.1006298.

02/20/2019

Featured Collection

Machine Learning in Health and Biomedicine

In this Collection, PLOS ONE, PLOS Computational Biology, PLOS Medicine and our teams of Guest Editors feature research that applies machine learning methods to health and biomedicine.

Machine Learning in Health and Biomedicine

Image credit: StockSnap, Pixabay.

02/27/2019

Featured Channel

Open Source Toolkit

Currently featuring work from PLOS Computational Biology, the Open Source Toolkit is a channel for projects describing hardware and software that can be used in a research and/or science education setting across different fields, from basic to applied research.

Open Source Toolkit

Image credit: Lafita et al, pcbi.1006791.

03/02/2019

Featured Blog Post

Data Sharing: Better for Everyone, Especially You!!

PLOS Biology Chief Editor Emma Ganley discusses the benefits of data sharing, open data, and open science in general in this blog post for Open Data Day 2019.

Data Sharing: Better for Everyone, Especially You!!

Image credit: PLOS.

Get new content from PLOS Computational Biology in your inbox

Thank you! You have successfully subscribed to the PLOS Computational Biology newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

Try again