The intrinsic dimension of protein sequence evolution

Malandrino et al. demonstrate, through a computational and experimental study, that cell-generated dynamic local forces rapidly and mechanically remodel the extracellular matrix, creating a non-homogeneous, densified region around the cell. This substantially increases ECM protein concentration in the vicinity of cells and alters matrix mechanical properties over time, creating a new microenvironment.

The negative effects of extremely competitive academic and research environments on the performance and health of researchers are well known and common worldwide. The prevalence of these effects, particularly among early career researchers, calls for a more humane and people-centered way of working within research labs. Here, Maestre introduces 10 simple rules to make the working environment of research labs more nurturing, collaborative, and people-centered.