A multi-scale model of gas transport in the lung to study heterogeneous lung ventilation during the multiple-breath washout test
Computational models help us to understand the relation between anatomical structure and physiological properties of the lung, but none of them has dealt with the multiple-breath washout (MBW) test in whole. Hasler, Anagnostopoulou et al. aimed to create a lung model that simulates the entire MBW test and study the role of lung structure and tissue mechanics on the washout procedure.
Image credit: Hasler, Anagnostopoulou et al, pcbi.1007079.