Ten simple rules for funding scientific open source software

Jiang et al have created a method for the time-series analysis of local subcellular processes across the entire cell by adapting optical flow based, nonlinear image registration. The research team leveraged new capacity of sampling at every subcellular location for the discovery of organized Profilin dynamics in symmetry-breaking and polarizing cells, which in turn are related to the dynamics of its regulatory target Actin.

Understanding how tissue-scale morphogenesis arises from cell mechanics and cell-cell interactions is a fundamental question in developmental biology. This study proposes a mathematical and numerical framework that describes each cell as an active surface representing the cell acto-myosin cortex, subjected to shape changes according to active tensions, and to interaction with neighbouring cells in the tissue. This method accounts for cellular processes such as cortical flows, cell adhesion, and cell shape changes in a deforming three-dimensional cell aggregate.

How people use green spaces and their impact on urban biodiversity is not well understood, particularly because it is difficult to monitor human activity. This study used anonymized GPS data from smart devices to quantify green space usage in Southern Ontario.