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Host contact dynamics shapes richness and dominance of pathogen strains

May 21, 2019

Host contact dynamics shapes richness and dominance of pathogen strains

Image credit: Pinotti et al, pcbi.1006530.

05/23/2019

Research Article

Epidemic prevalence information on social networks can mediate emergent collective outcomes in voluntary vaccine schemes

In the course of an epidemic outbreak individuals may opt to vaccinate because of the associated higher risk perception. Modeling individual decision-making in the presence of an evolving epidemic using games, Sharma et al. show that spatial heterogeneity in the vaccine-uptake behavior emerges with the spread of disease on social networks.

Image credit: Sharma et al, pcbi.1006977.

Epidemic prevalence information on social networks can mediate emergent collective outcomes in voluntary vaccine schemes

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Current Issue April 2019

05/20/2019

Research Article

Reduced level of docosahexaenoic shifts GPCR neuroreceptors to less ordered membrane regions

Certain neuroreceptor proteins are regulated by membrane cholesterol that is enriched in ordered membrane domains. These domains contain polyunsaturated fatty acids (PUFAs) that interact favorably with many receptor proteins. Javanainen et al. hypothesize that this decrease in PUFAs somehow inhibits receptor partitioning to cholesterol-rich domains, which could compromise their function.

Image credit: Javanainen et al, pcbi.1007033.

Reduced level of docosahexaenoic shifts GPCR neuroreceptors to less ordered membrane regions

05/23/2019

Research Article

Forecasting national and regional influenza-like illness for the USA

The CDC collects and disseminates influenza-like illness information, and runs a forecasting challenge (the CDC Flu Challenge) for modelers to predict near-term weekly incidence, week of season onset, week of peak, and intensity of peak. Ben-Nun et al. have developed a modeling framework that accounts for a range of mechanisms thought to be important for influenza transmission, such as climatic conditions, school vacations, and coupling between different regions.

Image credit: Ben-Nun et al, pcbi.1007013.

Forecasting national and regional influenza-like illness for the USA

05/23/2019

Education

Establishing a computational biology flipped classroom

In a flipped classroom, students complete automated modules to replace a traditional lecture, giving that time to tasks reinforcing student knowledge. Is it possible to successfully flip a classroom in an advanced, heavily specialized course like a bioinformatics algorithms course? Over the past few years, the author has implemented a flipped version of such a course and will discuss some of the successes and pitfalls.

Establishing a computational biology flipped classroom

Image credit: McGeddon, Wikimedia Commons.

05/14/2019

Research Article

Interacting cells driving the evolution of multicellular life cycles

Evolution of multicellular life began from the emergence of cell clusters. This provided them with an advantage over unicellular life. However, what kind of interactions lead to the evolution of multicellular life cycles? Gao et al. combine evolutionary game theory with a model for the emergence of multicellular groups to investigate how cell interactions can influence reproduction modes during the early stages of evolution of multicellularity.

Interacting cells driving the evolution of multicellular life cycles

Image credit: Gao et al, pcbi.1006987.

04/30/2019

Featured Channel

Stem Cells

Not only can stem cells provide us with a deeper understanding of the core mechanics of cell biology, they can also be applied in biomedical studies exploring tissue repair and regeneration. This Channel curates the most up to date and impactful research and resources of interest to the stem cells community.

Stem Cells

Image credit: Eugene Russo

05/26/2009

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From cell division to tissue network topology.

Cell division is a key mechanism in morphogenesis, yet the relationship between local cell division and global tissue architecture (e.g., the distribution of cell shapes) remains poorly understood.

From cell division to tissue network topology.

Image credit: Ankit Patel, Radhika Nagpal (Harvard University).

03/29/2012

Featured Collection

Topic Pages

This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.

Topic Pages

Image credit: Monika Fischer, Flickr.

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