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10/07/2019

Research Article

Predicting gait adaptations due to ankle plantarflexor muscle weakness and contracture using physics-based musculoskeletal simulations

Deficits in the ankle plantarflexors are thought to contribute to abnormal walking patterns. To study how, Ong et al. used computer simulations to systematically introduce muscle deficits in a biomechanically accurate model. They found that severe weakness of the ankle plantarflexors caused the model to adopt a slower, “heel-walking” gait, and severe tightness caused it to adopt a crouched, “toe-walking” gait.

Image credit: Ong et al, pcbi.1006993.

Predicting gait adaptations due to ankle plantarflexor muscle weakness and contracture using physics-based musculoskeletal simulations

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Current Issue September 2019

10/09/2019

Research Article

miRWoods: Enhanced precursor detection and stacked random forests for the sensitive detection of microRNAs

While the computational prediction of microRNA loci from high-throughput sequence data is well-studied, challenges persist in defining the minimum number of reads required for a locus to be evaluated, as well as in defining the precursor span. Bell et al. present a new method, “miRWoods”, which has greater recall of known microRNAs, while also achieving as good or better overall performance.

Image credit: Bell et al, pcbi.1007309.

miRWoods: Enhanced precursor detection and stacked random forests for the sensitive detection of microRNAs

10/07/2019

Research Article

A simulation of the random and directed motion of dendritic cells in chemokine fields

Dendritic cells use filopodia to pull themselves forward, and orient their filopodia based on signals received from chemokines. Parr et al. developed a model of dendritic cell motion based on a force balance, in which pulling from filopodia (calculated from a well-established model of filopodial adhesion-clutch dynamics) is counterbalanced by adhesive friction, and where the angular orientation of filopodia is based on the strength of chemotactic signal.

Image credit: Parr et al, pcbi.1007295.

A simulation of the random and directed motion of dendritic cells in chemokine fields

09/19/2019

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Complexity

The latest update to the Complexity Channel features research from PLOS Medicine, Science Advances, and PLOS Computational Biology.

Complexity

Image credit: Andy Lamb.

03/29/2012

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Nerve cell on worn paper. 

This image illustrates a B4 neuron from the mollusk Lymnaea stagnalis on a background of mathematical expressions, simulation data, and binary digits.

Nerve cell on worn paper. 

Image credit: Dimitrios V. Vavoulis and Volko A. Straub, the Universities of Warwick and Leicester, United Kingdom, 2012.

10/03/2019

Featured Collection

High-Quality Health Systems

This Collection on High Quality Health Systems has published a range of research papers on the measurement, improvement, and ethics of health system quality.

High-Quality Health Systems

Image credit: sumanley, pixabay.

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