June 8, 2023
Image credit: pcbi.1010627
06/12/2023
Research Article
This study presents a new, modular framework for building highly realistic models of malaria drawing on a century of research and innovation. Using this framework the authors develop metrics for parasite dispersal, local reproductive numbers, and malaria connectivity, re-examining human biting rates and entomological inoculation rates.
Image credit: Wolfgang Hasselman (Unsplash)
Current Issue July 2023
06/12/2023
Research Article
The cellular cytosol harbors diverse molecules, whose crowding slows down diffusion and perturbs the chemical equilibrium of biochemical reactions. This study simulates a model cell with crowding-adjusted metabolic reaction kinetics. Its cytosol accommodates two types of reactions: metabolic reactions, involving small molecules, and protein production reactions that involve much larger molecules.
Image credit: CDC
06/02/2023
Research Article
This study introduces and tests a flexible epidemiological framework for landscape-scale disease management of an emerging vector-borne pathogen for use with endemic and invading vector populations. It uses the framework to analyze and predict the spread of Huanglongbing disease or citrus greening in the U.S.
Image credit: Enzo Lo Presti (Unsplash)
06/01/2023
Research Article
Human behavior emerges from planning over elaborate decompositions of tasks into goals, subgoals, and low-level actions. This study proposes a framework on the simple idea that people decompose tasks to reduce the overall cost of planning while maintaining task performance.
Image credit: Fig 1 Correa et al
05/30/2023
Research Article
The synthesis of new DNA strands initiates at multiple sites, termed replication origins, propagates bidirectionally, and terminates by merging of converging strands. This work reveals the exact propensity of any site to initiate replication along human chromosomes
Image credit: Anirudh (Unsplash)
05/05/2023
Research Article
Our perceptual system can actively adapt to the statistical properties of the environment in multiple time scales - the perceived duration of an event is biased by the mean duration of events observed in a relatively long period and by the durations of recent events. This study investigates the mechanisms behind this.
Image credit: Nathan Dumlao (Unsplash)
05/04/2023
Research Article
By integrating molecular profiles of a large panel of cell lines from the DEMETER2 dataset, this study built a binary classifier to predict a tumor’s KRAS dependency.
Image credit: NIH
05/01/2023
Research Article
This study identified distinct signals of cortical calcium dynamics and spatially segments the signal sources into components that can be characterized.
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06/02/2022
Editorial (invitation only)
A report on the impact of the enhanced code sharing policy at PLOS Computational Biology, one year on from launch.
Image credit: Pexels, Pixabay
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
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