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Size and structure of the sequence space of repeat proteins

August 15, 2019

Size and structure of the sequence space of repeat proteins

Image credit: Marchi et al, pcbi.1007282.

08/12/2019

Research Article

Machine learning-based microarray analyses indicate low-expression genes might collectively influence PAH disease

PAH is a serious progressive disease, with only a roughly 50% of 5-year survival rate. Accurately detecting/differentiating different forms of PAH and developing drugs that could directly target at genes involved in PAH pathogenesis are essential. Cui et al. proposed a computational approach using low-cost microarray data collected from a clinical trial and had accurately predicted each PAH group.

Image credit: Cui et al, pcbi.1007264.

Machine learning-based microarray analyses indicate low-expression genes might collectively influence PAH disease

Recently Published Articles

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Current Issue

Current Issue July 2019

08/15/2019

Research Article

Recombination and mutational robustness in neutral fitness landscapes

Two long-standing and seemingly unrelated puzzles in evolutionary biology concern the ubiquity of sexual reproduction and the robustness of organisms against genetic perturbations. Using an approach based on the concept of a fitness landscape Klug et al. argue that the two phenomena may be closely related. The increase of robustness may be a major driver underlying the evolution of sexual recombination and other forms of genetic exchange in the living world.

Image credit: Klug et al, pcbi.1006884.

Recombination and mutational robustness in neutral fitness landscapes

08/15/2019

Research Article

Pulse transit time estimation of aortic pulse wave velocity and blood pressure using machine learning and simulated training data

Recently there has been a strong trend for self-monitoring of cardiovascular health and new 'wearables' are coming to the market everyday. Such solutions are mostly taking advantage of heart rate measurement. Huttunen et al. use computational modelling to assess the theoretical capabilities of other health measurements such as blood pressure and pulse wave velocity.

Image credit: Huttunen et al, pcbi.1007259.

Pulse transit time estimation of aortic pulse wave velocity and blood pressure using machine learning and simulated training data

08/09/2019

Research Article

A generative learning model for saccade adaptation

Constant adjustments of saccade metrics maintain oculomotor accuracy in changing environments. This error-driven learning can be induced experimentally by manipulating the targeting error of eye movements. Cassanello et al. investigate oculomotor learning in healthy participants in response to a sinusoidally evolving error.

A generative learning model for saccade adaptation

Image credit: Cassanello et al, pcbi.1006695.

08/05/2019

Research Article

Colony entropy—Allocation of goods in ant colonies

Greenwald et al. study how food is distributed in colonies of ants. Food collected by a small fraction of ants is distributed throughout the colony through a series of mouth-to-mouth interactions. Tracking fluorescent-labelled food and interpreting the results within the concepts of information theory, they show that food collected by each forager reaches almost every ant in the colony.

Colony entropy—Allocation of goods in ant colonies

Image credit: Greenwald et al, pcbi.1006925.

08/05/2019

Featured CHANNEL

Complexity

The latest update to the Complexity Channel includes research and education articles from PLOS Computational Biology.

Complexity

Image credit: Andy Lamb

06/30/2017

Featured Issue Image

Five Seals.

Repeat-proteins fold cooperatively into elongated arrays of similar structural elements. The image represents the structure of the I-kappa-B-alpha protein as modeled from x-ray crystallography (bottom) and as a biological object (top).

Five Seals.

Image credit: May-K (@proteinart).

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