Large-scale, dynamin-like motions of the human guanylate binding protein 1 revealed by multi-resolution simulations

While the computational prediction of microRNA loci from high-throughput sequence data is well-studied, challenges persist in defining the minimum number of reads required for a locus to be evaluated, as well as in defining the precursor span. Bell et al. present a new method, “miRWoods”, which has greater recall of known microRNAs, while also achieving as good or better overall performance.

Dendritic cells use filopodia to pull themselves forward, and orient their filopodia based on signals received from chemokines. Parr et al. developed a model of dendritic cell motion based on a force balance, in which pulling from filopodia (calculated from a well-established model of filopodial adhesion-clutch dynamics) is counterbalanced by adhesive friction, and where the angular orientation of filopodia is based on the strength of chemotactic signal.