December 3, 2018
Image credit: Hay et al.
12/05/2018
Research Article
Ghosh et al. created new spatially accurate computational models of cardiac cell bioenergetics and tested whether this heterogeneous distribution of mitochondria causes non-uniform energy supply and contractile force production in the cardiomyocyte.
Image credit: Ghosh et al.
Current Issue November 2018
12/03/2018
Software Article
Many microbes are studied by examining colony morphology via two-dimensional top-down images. The quantification of such images requires each pixel to be labelled as belonging to either the colony or background, producing a binary image. While this may be achieved manually for a single colony, this is infeasible for large datasets containing thousands of images. TAMMiCol has been developed to efficiently and automatically convert colony images to binary.
Image credit: Tronnolone, Gardner et al.
12/03/2018
Research Article
In this study, by uniquely adapting techniques for the identification of coherent structures in fluid turbulence, Townsend et al. develop new analytical and computational methods for the reliable detection of a diverse range of propagating wave patterns in large-scale neural recordings, for comprehensive analysis and visualization of these patterns, and for analysis of their dominant spatiotemporal modes.
Image credit: Townsend et al.
12/06/2018
Research Article
Grado et al. present a novel Bayesian adaptive dual controller (ADC) for autonomously programming deep brain stimulation devices. They show that the Bayesian ADC can efficiently optimize stimulation parameters, and is superior to other optimization algorithms.
Image credit: Grado et al.
12/06/2018
Research Article
Bochicchio et al. present a study that sheds light on the molecular recognition of the complex between RRM-bearing protein Rbfox and its RNA target pre-miR21.
Image credit: Bochicchio et al.
12/03/2018
Research Article
Here, Zhang et al. propose a comprehensive ensemble model which includes both ordered and disordered states of a two-domain protein, and investigate the role of various state combinations in allosteric effect.
Image credit: Zhang et al.
03/01/2018
Featured Collection
In this Collection, PLOS ONE, PLOS Computational Biology, PLOS Medicine and our teams of Guest Editors feature research that applies machine learning methods to health and biomedicine.
Image credit: StockSnap/ pixabay.
12/26/2013
Featured Issue Image
Epidemics spread along networks of infectious contacts, in particular those with high contact intensity or weight.
Image credit: Andreas Bunten and clix.
12/01/2018
Top Tweet
Data central to everything but we spend little time teaching academic & field staff basic principles of how to do this well - good piece @PLOSCompBiol http://bit.ly/2KNwvhL on why we need to make Good Data Practice standard - as important as GCP #datasaveslives
Image credit: Twitter.
11/19/2018
Featured CHannel
The Open Source Toolkit features articles and online projects describing hardware and software that can be used in a research and/or science education setting across different fields, from basic to applied research.
Image credit: Jen Owens.
The PLOS Computational Biology Methods Section was launched in 2013 and has given computational method development a dedicated space in the journal.
The articles in this collection consider factors associated with the inclusion and success of women in STEM fields and propose ways to reduce the gender gap.
This Focus Feature addresses some of the most exciting current opportunities and challenges in the field of Network Biology.
Breast cancer remains a major public health problem...
Advancing the beneficial use of machine learning in health care and medicine: Toward a community understanding
Gut microbiota diversity across ethnicities in the United States
Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds
Rapid and highly-specific generation of targeted DNA sequencing libraries enabled by linking capture probes with universal primers
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