02/17/2021
Research Article
Role of neutrophil extracellular traps in regulation of lung cancer invasion and metastasis: Structural insights from a computational model
Image credit: Lee et al. pcbi.1008257
February 22, 2021
Calcium-vesicles perform active diffusion in the sea urchin embryo during larval biomineralization
Image credit: Winter et al. pcbi.1008780
Recently Published Articles
- Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of action
- Inferring latent temporal progression and regulatory networks from cross-sectional transcriptomic data of cancer samples
- Using deep neural networks to evaluate object vision tasks in rats
Current Issue February 2021
02/17/2021
Research Article
Data-driven method to infer the seizure propagation patterns in an epileptic brain from intracranial electroencephalography
Sip et al. introduce a method to infer what is happening in the unobserved parts based on the incomplete observations of the epileptic seizure.
Image credit: Sip et al. pcbi.1008689
02/11/2021
Editorial
On the open-source landscape of PLOS Computational Biology
In this paper Boudreau et al. examine the open-source landscape of PLOS Computational Biology. All the articles published in PLOS Computational Biology from January to December 2019 were downloaded. A script was then executed to search for all the articles that contained one of a list of keywords that may hint at containing code/data.
Image credit: Boudreau et al. pcbi.1008725
02/10/2021
Research Article
Adaptive social contact rates induce complex dynamics during epidemics
Arthur et al. develop a theoretical strategic model that introduces lost or gained economic and public health utility through the adjustment of social contact rates with delayed information.
Image credit: Arthur et al. pcbi.1008639
02/03/2021
Research Article
ViralLink: An integrated workflow to investigate the effect of SARS-CoV-2 on intracellular signalling and regulatory pathways
Trevail et al. developed ViralLink: a systems biology workflow which reconstructs and analyses networks representing the effect of viruses on intracellular signalling.
Image credit: Treveil et al. pcbi.1008685
02/01/2021
Research Article
Directed attenuation to enhance vaccine immunity
Antia et al. use models to explore ways of directing the attenuation of a virus to avoid tradeoff whereby attenuation depresses the within-host viral load and pathology (which is beneficial to vaccine design), but reduces immunity (which is not beneficial). Antia et al. show that directed attenuation by interfering with (some) viral immune-evasion pathways can yield a mild infection but elicit higher levels of immunity than of the wild-type virus.
Image credit: Antia et al pcbi.1008602
11/18/2019
Featured Collection
Ten Simple Rules
"Ten Simple Rules" provide a quick, concentrated guide for mastering some of the professional challenges research scientists face in their careers.
Image credit: PLOS
01/20/2020
Top Tweet
SIO Acoustic Ecology
Excited to share our latest article: DetEdit: A graphical user interface for annotating and editing events detected in long-term acoustic monitoring data, published in @ploscompbiol: journals.plos.org/ploscompbiol/a ... #ploscompbiolauthor. Try it, play with it.
Image credit: Twitter.
11/26/2009
Featured Issue Image
LocaNMF for region-based decomposition of neural recordings from the mouse brain
Widefield calcium imaging provides a global view of neural activity in the mouse dorsal cortex.
Image credit: Shreya Saxena (Columbia University)
05/05/2020
Featured Blog Post
Improving reproducibility of computational models
In this piece, we announce a pilot (now closed) to support reproducibility by offering expert technical peer review, specifically checking that submitted systems biology or physiology-based models run according to the results presented in the manuscript.
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Image credit: PLOS.
Collections
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Topic Pages
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
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Developing Computational Biology
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
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Education
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
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Benchmarking
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
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PLOS Biology
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
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PLOS Neglected Tropical Diseases
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
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PLOS Pathogens
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
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PLOS Medicine
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
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