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Ten simple rules for funding scientific open source software

November 17, 2022

Ten simple rules for funding scientific open source software

Image credit: PLOS pcbi.1010627

12/21/2022

Research Article

A method to estimate the cellular composition of the mouse brain from heterogeneous datasets

This study builds on previous work in creating a cell atlas to provide an estimate of the densities of neurons, glia and their subtypes for each region in the mouse brain. Here, the research team describes an extension of this model to include more inhibitory neuron types using brain slice images to estimate inhibitory neuron density in regions where no literature data is available. 

Image credit: Rodarie et al

A method to estimate the cellular composition of the mouse brain from heterogeneous datasets

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Current Issue

Current Issue November 2022

12/22/2022

Education

Ten simple rules for empowering women in STEM

This Ten Simple Rules piece provides advice on potential pitfalls and strategies to develop strong female researchers who are correctly credited and recognized for their work.

Image credit: Letters written by Rafaella Simancas and Julia Palacios

Ten simple rules for empowering women in STEM

12/27/2022

Research Article

Robust and brain-like working memory through short-term synaptic plasticity

Working memory has been thought to depend on sustained spiking alone. But recent evidence shows that spiking is often sparse, not sustained in working memory. This study tests whether Short-term synaptic plasticity (STSP) could help by maintaining memories between spiking by comparing artificial recurrent neural networks with and without STSP. 

Image credit: Kozachkov et al

Robust and brain-like working memory through short-term synaptic plasticity

12/30/2022

Research Article

Fine-grained, nonlinear registration of live cell movies reveals spatiotemporal organization of diffuse molecular processes

Jiang et al have created a method for the time-series analysis of local subcellular processes across the entire cell by adapting optical flow based, nonlinear image registration. The research team leveraged new capacity of sampling at every subcellular location for the discovery of organized Profilin dynamics in symmetry-breaking and polarizing cells, which in turn are related to the dynamics of its regulatory target Actin.

Fine-grained, nonlinear registration of live cell movies reveals spatiotemporal organization of diffuse molecular processes

Image credit: Jiang et al

01/16/2023

Research Article

Interacting active surfaces: A model for three-dimensional cell aggregates

Understanding how tissue-scale morphogenesis arises from cell mechanics and cell-cell interactions is a fundamental question in developmental biology. This study proposes a mathematical and numerical framework that describes each cell as an active surface representing the cell acto-myosin cortex, subjected to shape changes according to active tensions, and to interaction with neighbouring cells in the tissue. This method accounts for cellular processes such as cortical flows, cell adhesion, and cell shape changes in a deforming three-dimensional cell aggregate.

Interacting active surfaces: A model for three-dimensional cell aggregates

Image credit: Salbreux et al

12/15/2022

Research Article

Using smartphone-GPS data to quantify human activity in green spaces

How people use green spaces and their impact on urban biodiversity is not well understood, particularly because it is difficult to monitor human activity. This study used anonymized GPS data from smart devices to quantify green space usage in Southern Ontario.

Using smartphone-GPS data to quantify human activity in green spaces

Image credit: Filazzola et al.

11/11/2021

Featured Issue Image

Diverse brain processing of sound localization in barn owls

Gorman et al investigated how neural connectivity and single-neuron computation may contribute to the emergence of spatial selectivity in auditory neurons in the barn owl's midbrain.

Diverse brain processing of sound localization in barn owls

Image credit: José Luis Peña

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PLOS Computational Biology | ISSN: 1553-7358 (online)