October 10, 2022
Image credit: Galappaththige et al pcbi.1010541
10/03/2022
Research Article
To study early events in phagocytosis, Herron et al used “frustrated phagocytosis”, an experimental system in which antibodies are micropatterned in disks on a cover slip. The cytoskeleton of cells attempting to phagocytose these disks organizes into “rosette” patterns around the disks, and they show that this pattern formation can occur through two general mechanisms.
Image credit: Herron et al, pcbi.1010092
Current Issue September 2022
10/03/2022
Research Article
Holmes, Goldman and Kalli demonstrated conservation of lipid-interaction sites on proteins from two species that deviated from their evolutionary common ancestors a long time ago, using the membrane-integral pyrophosphatases from a thermophilic bacteria species and a plant species.
Image credit: Holmes, Goldman and Kalli, pcbi.1010578
10/07/2022
Research Article
This new study from Attard, Welburn and Marsh presents tubulins as a weakness of current computational predictors, potentially because they fail to consider different ways in which mutations cause disease.
Image credit: Attard, Welburn and Marsh, pcbi.1010611
10/07/2022
Research Article
These researchers find that the antipsychotic drug trifluoperazine (TFP) encourages Calmodulin (CaM), a calcium-sensing protein, to adopt a conformation that is like the one stabilized in absence of calcium.
Image credit: Westerlund and Sridhar et al, pcbi.101058
10/14/2022
Research Article
In this new study, “A deep learning approach to real-time HIV outbreak detection using genetic data,” these researchers present a new approach that is efficient, accurate, scalable, and can analyze data in real time.
Image credit: Kupperman, Leitner and Ke, pcbi.1010598
10/07/2022
Research Article
This new paper from Hiraga, Yamada and Kobayashi describes a simple mathematical model for investigating the active listening strategy employed by bats, and also opens up the possibility of engineering applications for active listening systems.
Image credit: Hiraga, Yamada and Kobayashi, pcbi.1009784
11/11/2021
Featured Issue Image
Gorman et al investigated how neural connectivity and single-neuron computation may contribute to the emergence of spatial selectivity in auditory neurons in the barn owl's midbrain.
Image credit: José Luis Peña
08/02/2021
FEATURED COLLECTION
The reproducibility of research is a crucial element to keep science moving forward.
Image credit: PLOS
06/02/2022
Editorial (invitation only)
A report on the impact of the enhanced code sharing policy at PLOS Computational Biology, one year on from launch.
Image credit: Pexels, Pixabay
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
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