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Statistics of correlated percolation in a bacterial community

December 2, 2019

Statistics of correlated percolation in a bacterial community

Image credit: Zhai et al, pcbi.1007508.

12/02/2019

Research Article

A computational study on the role of glutamate and NMDA receptors on cortical spreading depression using a multidomain electrodiffusion model

In this paper, Tuttle et al. study the mechanisms by which cortical spreading depression travels as a wave through the brain. They construct a detailed mathematical model based on the physics of ion movement as well as what is known about the molecular players of cortical spreading depression.

Image credit: Tuttle et al, pcbi.1007455.

A computational study on the role of glutamate and NMDA receptors on cortical spreading depression using a multidomain electrodiffusion model

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Current Issue November 2019

12/02/2019

Research Article

CBNA: A control theory based method for identifying coding and non-coding cancer drivers

To design better diagnostic and therapeutic plans for cancer patients, we need to know the roles of cancer drivers in cancer development as well as their regulatory mechanisms in the human body. In this study, Pham et al. propose a novel framework to identify coding and non-coding cancer drivers (i.e. miRNA cancer drivers). The proposed framework is applied to the breast cancer dataset for identifying drivers of breast cancer.

Image credit: Pham et al, pcbi.1007538.

CBNA: A control theory based method for identifying coding and non-coding cancer drivers

12/02/2019

Research Article

The effect of inhibition on rate code efficiency indicators

Cortical neurons typically receive a signal from many different neurons, which, depending on the synapse type, either depolarize (excitatory input) or hyperpolarize (inhibitory input) the neural membrane. Barta et al. use a neural model with excitatory and inhibitory synaptic conductances to reproduce in-vivo like activity and investigate how the intensity of presynaptic inhibitory activity affects the neuron’s ability to transmit information through rate code.

Image credit: Barta et al, pcbi.1007545.

The effect of inhibition on rate code efficiency indicators

11/25/2019

Research Article

A novel network control model for identifying personalized driver genes in cancer

Guo et al. propose a model to identify the personalized driver genes by employing the structure-based network control principle on genetic data of individuals. They present a paired single sample network construction method to construct the personalized state transition network for capturing the transitions between healthy and disease states.

A novel network control model for identifying personalized driver genes in cancer

Image credit: Guo et al, pcbi.1007520.

11/25/2019

Research Article

Efficient sentinel surveillance strategies for preventing epidemics on networks

In a network of individuals susceptible to infectious disease, what are the best locations to monitor in order to detect the infection quickly? Colman et al. consider various heuristic strategies for sentinel placement that can be implemented in real-world situations without requiring excessive computation, or having perfect data about the network structure.

Efficient sentinel surveillance strategies for preventing epidemics on networks

Image credit: Colman et al, pcbi.1007517.

11/26/2019

Research Article

The role of intracellular interactions in the collective polarization of tissues and its interplay with cellular geometry

In spite of the advances in understanding the different modules of PCP, a comprehensive picture of the intracellular protein-protein interactions necessary for the emergence of long-range tissue polarity is still lacking. Shadkhoo et al. devise a generalized reaction-diffusion model, and investigate the role of cytoplasmic interactions in PCP pathways.

The role of intracellular interactions in the collective polarization of tissues and its interplay with cellular geometry

Image credit: Shadkhoo et al, pcbi.1007454.

12/05/2019

Featured Blog Post

Celebrating 6 Months of Published Peer Review at PLOS

We recently passed our six-month anniversary of published peer review options at PLOS! To celebrate this huge step towards transparency – and to be transparent about our own findings – we want to share what we’ve learned from this process so far.

Celebrating 6 Months of Published Peer Review at PLOS

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09/30/2015

Featured Issue Image

Prospective Optimization with Limited Resources

Gepshtein et al. studied how humans select actions under such extrinsic and intrinsic uncertainty, in view of the exponentially expanding number of prospects on a branching multivalued visual stimulus.

Prospective Optimization with Limited Resources

Image credit: Gepshtein et al. and Trisha Williams of Pigeon Hole Productions

09/28/2007

Featured Collection

Developing Computational Biology

This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.

Developing Computational Biology

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