July 19, 2021
Image credit: Yuval et al. pcbi.1009185
08/05/2021
Editorial
In this paper Hooley et al. share 10 simple rules based on our experiences from delivering an applied practical course to a diverse set of students in a flexible, supportive, and engaging online learning environment.
Image credit: Hooley et al. pcbi.1009184
Current Issue August 2021
07/28/2021
Research Article
Here Ljungholm and Nilsson use ray tracing applied to accurate anatomical/optical models of the eyes of a velvet worm to reconstruct the visual acuity in all parts of the visual field. They calculated visual performance to closely simulate what animals would see in their natural habitat. The method can be applied to any (preferably small) eye and offers an alternative strategy that may yield information about the visual capacity that is otherwise hard to obtain.
Image credit: Ljunghoml,Nilsson. pcbi.1008808
08/06/2021
Research Article
Zhao et al. propose a theoretical generalization of the maximum entropy approach that allows them to model very high dimensional data; at least an order of magnitude higher than what is currently possible. This framework will be a significant advancement in the computational analysis of covarying binary variables.
Image credit: Zhao et al pcbi.1009275
08/02/2021
Research Article
The goal of this study is to elucidate the mathematical principles for representing tone frequency and intensity in neural networks. This mathematical approach offers new insights into experimental data and a framework for constructing network models
Image credit: Reyes pcbi.1009251
08/05/2021
Education
This 15 quick tips guide is aimed at helping you identify ways to improve your utilisation of HPC, avoiding common pitfalls that can negatively impact other users and will also help ease the load on your HPC sysadmin.
Image credit: Alnasir pcbi.1009207
07/26/2021
Research Article
In this study, the authors investigated the allosteric mechanism of ZTL in both parallel and anti-parallel dimeric states through computational means. They provide mechanistic and dynamic models with atomistic details underlying the functions of this circadian clock protein ZEITLUPE.
Image credit: Trozzi et al. pcbi.1009168
11/18/2019
Featured Collection
"Ten Simple Rules" provide a quick, concentrated guide for mastering some of the professional challenges research scientists face in their careers.
Image credit: PLOS
08/02/2021
FEATURED COLLECTION
The reproducibility of the research is a crucial element to keep science moving forward. I
Image credit: PLOS
03/30/2021
FEATURED BLOG POST
PLOS Computational Biology has adopted an enhanced code sharing policy for all papers submitted from 30 March 2021.
Image credit: Hippopx
08/03/2020
FEATURED ISSUE IMAGE
Belcher et al estimated which clinically measurable properties of the tumor may help translate HBOC facilitated tumor oxygenation from murine models to the clinic.
Image credit: Belcher et al. pcbi.1008157
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
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