January 6, 2021
Image credit: Jagannathan et al. pcbi.1008474
01/21/2021
research article
In this work, Murase and Baek propose a strategy for the iterated n-person public-goods game based on the following five rules: Cooperate if everyone did, accept punishment for your own mistake, punish others’ defection, recover cooperation if you find a chance, and defect in all the other circumstances.
Image credit: Murase et al. pcbi.1008217
Current Issue February 2021
01/14/2021
Editorial
Bodner et al. present 10 simple rules for tackling your first mathematical model with rules that are applicable to basic scientific research. As graduate students themselves, they have created rules they wish they had internalized before beginning their model-building journey and hope they prove insightful for others.
Image credit: Bodner et al. pcbi.1008539
01/19/2021
Research Article
Gordin et al. studied the alpha and beta chain CDR3 domains of TCR repertoires of CD4 T cells using deep sequencing of cell populations in mice and applied the results to published TCR sequence data obtained from human patients. Their findings suggest that the development of breast cancer is associated, across species, with biomarker, exclusive TCR repertoires.
Image credit: Gordin et al. pcbi.1008486
01/22/2021
Research article
Image credit: Kurkjian et al. pcbi.1008643
01/19/2021
Research Article
Frameshifting is triggered by a particular structure in the viral RNA, a pseudoknot, which is a promising drug target. Here Omar et al. model the structure of this pseudoknot through atomistic molecular dynamics simulations.
Image credit: Omar et al. pcbi.1008603
01/06/2021
Research Article
In this study Patumcharoenpol et al. developed MetGEMs (metagenome-scale models) toolbox, a strategic approach to infer metabolic functions from 16S rRNA gene sequences with overall aiming at annotating metabolic functions in the human gut microbiome.
Image credit: Patumcharoenpol et al. pcbi.1008487
11/18/2019
Featured Collection
"Ten Simple Rules" provide a quick, concentrated guide for mastering some of the professional challenges research scientists face in their careers.
Image credit: PLOS
01/20/2020
Top Tweet
Excited to share our latest article: DetEdit: A graphical user interface for annotating and editing events detected in long-term acoustic monitoring data, published in @ploscompbiol: journals.plos.org/ploscompbiol/a ... #ploscompbiolauthor. Try it, play with it.
Image credit: Twitter.
11/26/2009
Featured Issue Image
Widefield calcium imaging provides a global view of neural activity in the mouse dorsal cortex.
Image credit: Shreya Saxena (Columbia University)
05/05/2020
Featured Blog Post
In this piece, we announce a pilot (now closed) to support reproducibility by offering expert technical peer review, specifically checking that submitted systems biology or physiology-based models run according to the results presented in the manuscript.
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Image credit: PLOS.
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
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