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07/16/2019

Research Article

Morphophenotypic classification of tumor organoids as an indicator of drug exposure and penetration potential

Here, Karolak et al. used mathematical modeling and computer simulations to analyze the structure of simulated tumor organoids and to classify them with regards to two quantitative features: the tumor accessible surface area (ASA) describing organoid exposure to the drug and the extent of drug penetration through the tumor tissue (organoid compactness).

Image credit: Karolak et al, pcbi.1007214.

Morphophenotypic classification of tumor organoids as an indicator of drug exposure and penetration potential

Recently Published Articles

Current Issue

Current Issue June 2019

07/15/2019

Research Article

Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction

Heusinkveld et al. integrated a novel vascular module describing wave transmission in vascular networks into the CircAdapt model of whole-heart mechanics. The extended CircAdapt model is now also able to quantitatively describe vascular haemodynamics, including wave dynamics.

Image credit: Heusinkveld et al, pcbi.1007173.

Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction

07/11/2019

Research Article

Modeling the daily rhythm of human pain processing in the dorsal horn

Patients with neuropathy experience a 12-hour shift in their pain rhythmicity: highest sensitivity occurs in the afternoon. Understanding the mechanism underlying this shift may lead to improvements in the knowledge of transmission of pain from the damaged nerve to the pain-processing center in the spinal cord, and thus better treatment protocols.

Modeling the daily rhythm of human pain processing in the dorsal horn

Image credit: dw_ross, Flickr.

07/11/2019

Perspective

Think: Theory for Africa

Africans represent a vast and growing human resource poised to make important contributions to neuroscience. As the third yearly IBRO-Simons Computational Neuroscience Imbizo recently wrapped up in South Africa, Currin et al. call for greater efforts to empower Africans to join the global neuroscience community and argue that the subfield of computational neuroscience is the ideal vehicle to do so.

Think: Theory for Africa

Image credit: Currin et al, pcbi.1007049.

06/17/2019

Featured Channel

Open Source Toolkit

The Open Source Toolkit features articles and online projects describing hardware and software that can be used in a research and/or science education setting across different fields, from basic to applied research

Open Source Toolkit

Image credit: Jen Owens.

07/17/2019

Featured Blog Post

Get to know an Academic Editor: Lars Juhl Jensen

PLOS will be attending the ISMB/ECCB conference in Basel, Switzerland starting July 21. Stop by booth 7 and say hello. Lars Juhl Jensen, an Academic Editor for PLOS Computational Biology, will also be in attendance. Here’s a brief interview with him.

Get to know an Academic Editor: Lars Juhl Jensen

Image credit: PLOS.

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