07/09/2026
research Article
Given the amino acid sequence of the original enzyme and a set of residues for which the local environment should be conserved, i.e., the catalytic site, the author's approach generates mutants that differ vastly in the overall sequence while retaining the geometry of the conserved region, thereby representing promising candidates for further experimental screening
Image credit: USGS
Current Issue June 2026
07/06/2026
research article
Longitudinal microbiome studies provide critical insights into microbial community dynamics and their relation to host health. Tensor decompositions offer a powerful framework for the unsupervised analysis of such data, yielding interpretable low-dimensional temporal patterns. However, existing approaches based on the CP model assume common temporal dynamics for all subjects and therefore cannot capture subject-specific trajectories.
Image credit: Sean Sinclair
06/22/2026
research Article
Understanding the dynamic interaction between the viral life cycle and immune signaling is crucial to designing effective antiviral strategies. Although significant progress has been made, quantitative models that can accurately capture the intricate interactions and the intertwined dynamics during viral infection of cells remain missing.
Image credit: Boddepalli et al
06/22/2026
Research Article
Patients with dangerous antibiotic-resistant bacteria have been treated with mixtures of bacteriophages — viruses that infect bacteria. This treatment is highly personalized because the right phages must be selected for each patient’s infection. Since bacteria quickly evolve resistance to phages, it is often unclear why a treatment works or fails, and how to design the best phage combinations.
Image credit: de Boer, Schooley, and Perelson
06/23/2026
Education
While many years are spent increasing our scientific expertise, the training that is needed on how exactly to review these important documents is often learned through practice; at times with little guidance. In addition to those new to the process (senior graduate students all the way to junior faculty members) seeking guidance on how to approach the task of peer review.
Image credit: Andre William
06/16/2026
research article
Whether interspecific competition is a major contributing factor to setting species’ range limits has been debated for a long time. Theoretical studies have proposed that the interactions between interspecific competition and disruptive gene flow along an environmental gradient can halt range expansion of ecologically...
Image credit: Bailey Zindel
05/13/2026
research article
For decades, scientists have tried to understand why certain works of art move us more than others. Yet, directly connecting what is in an image to how it makes us feel has proven elusive.
Image credit: Dmitruk et al
05/13/2026
research article
Macroscale brain activity can be captured using techniques like EEG and fMRI. However, the granular or more detailed activity of neurons and localized neural masses is inaccessible.
Image credit: Coronel-Oliveros et al
05/11/2026
Methods
Cell type annotation in single-cell RNA sequencing is a critical bottleneck, with existing automated methods facing limitations in accuracy, interpretability, and generalization to novel cell types.
Image credit: Li et al
04/03/2026
Education
As data generation continues to accelerate, the life science and health communities are facing a growing need to master core bioinformatics skills.
Image credit: Kimberly Farmer
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
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