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February 27, 2025

PLOS statement on recent US Executive Orders

PLOS remains committed to the principles of open science: integrity, transparency, inclusivity, and collaboration. Read more on our blog.

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04/14/2025

research article

Revealing non-trivial information structures in aneural biological tissues via functional connectivity

A central challenge in understanding several diverse processes in biology, including morphogenesis, wound healing, and development, is learning from empirical data how information is integrated to support tissue-level function and behavior. Significant progress in understanding information integration has occurred in neuroscience via the use of observable live calcium reporters throughout neural tissues. However, these...

Image credit: Blackiston et al

Revealing non-trivial information structures in aneural biological tissues via functional connectivity

Recently Published Articles

Current Issue

Current Issue April 2025

04/10/2025

Education

Ten quick tips to get you started with Bayesian statistics

The learning curve for Bayesian statistics is gradual, not steep, and benefits will quickly outweigh investments.

To aid students on this journey, the authors provide a list of 10 tips to help them get started with Bayesian statistics, as well as a compiled glossary for definitions of technical terms. 

Image credit: Gimenez et al

Ten quick tips to get you started with Bayesian statistics

04/04/2025

Perspective

Why the growth of arboviral diseases necessitates a new generation of global risk maps and future projections

The authors describe how current approaches to mapping arboviral diseases have become unnecessarily siloed, ignoring the strengths and weaknesses of different data types and methods. This places limits on data and model output comparability, uncertainty estimation and generalisation that limit the answers they can provide to pressing questions in arbovirus control. 

Image credit: Brady et al

Why the growth of arboviral diseases necessitates a new generation of global risk maps and future projections

04/11/2025

Research article

Dynamic brain connectivity predicts emotional arousal during naturalistic movie-watching

This study explores how the brain represents two key dimensions of emotional experience: valence and arousal. The authors built computational models on publicly available imaging data from people watching movies spanning different genres, aiming to predict moment-to-moment changes in emotional valence and arousal from patterns of connectivity.

Dynamic brain connectivity predicts emotional arousal during naturalistic movie-watching

Image credit: Rendy Novatino

03/27/2025

research Article

Analysis of systemic effects of dioxin on human health through template-and-anchor modeling

While the hazards of dioxins have been well documented, the challenge of developing a comprehensive understanding of the overall health impact of dioxins remains. This paper proposes to address this challenge with a new approach methodology consisting of a novel adaptation of the Template-and-Anchor modeling paradigm. 

Analysis of systemic effects of dioxin on human health through template-and-anchor modeling

Image credit: Kumbale et al.

03/20/2025

Research article

Unknotting RNA: A method to resolve computational artifacts

RNA 3D structure prediction often encounters entanglements, computational artifacts that complicate structural models, resulting in their exclusion from further studies despite the potentially accurate prediction of regions outside the entanglement. This study presents a protocol aimed at resolving such issues in RNA models while preserving the overall 3D fold and structural integrity

Unknotting RNA: A method to resolve computational artifacts

Image credit: Poblete et al

03/20/2025

research article

How immunity shapes the long-term dynamics of influenza H3N2

The authors present an integrated modelling framework of influenza transmission, immunity, and antigenic drift to show how individual-level exposure, and the build-up of population level immunity, shape the...

How immunity shapes the long-term dynamics of influenza H3N2

Image credit: CDC

03/11/2025

research article

Mixed recurrent connectivity in primate prefrontal cortex

The authors present a method to estimate the connectivity of a network using extracellular physiological measurements. The study measured pairwise correlations between neurons in the prefrontal cortex of monkeys performing a...

Mixed recurrent connectivity in primate prefrontal cortex

Image credit: Sigalas & Libedinsky

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