A computational study on the role of glutamate and NMDA receptors on cortical spreading depression using a multidomain electrodiffusion model
In this paper, Tuttle et al. study the mechanisms by which cortical spreading depression travels as a wave through the brain. They construct a detailed mathematical model based on the physics of ion movement as well as what is known about the molecular players of cortical spreading depression.
Image credit: Tuttle et al, pcbi.1007455.