September 17, 2018
Image credit: Miller et al
09/18/2018
RESEARCH ARTICLE
In this paper Babichev et al show how the spiking activity of principal cells in mammalian hippocampus encodes an internalized neuronal representation of the ambient space—a cognitive map. Once learned, such a map enables the animal to navigate a given environment for a long period.
Image credit: Babichev et al
Current Issue August 2018
09/18/2018
RESEARCH ARTICLE
Dynamics of biomolecular assemblies offer invaluable insights into their functional mechanisms. For extremely large biomolecular systems, such as HIV-1 capsid that has nearly 5 millions atoms, obtaining its normal mode dynamics using even coarse-grained models can be a challenging task. In this work, Na et al successfully carried out a normal mode analysis of an entire HIV-1 capsid in full all-atom details
Image credit: Na et al
09/14/2018
RESEARCH ARTICLE
Here Bhagwat et al use computational models that predict symptomatic progression at the individual level that can be highly beneficial for early intervention and treatment planning for Alzheimer’s disease (AD). Individual prognosis is complicated by many factors including the definition of the prediction objective itself.
Image credit: Bhagwat et al
09/17/2018
RESEARCH ARTICLE
Cope et al report that the capacity to learn abstract concepts such as ‘sameness’ and ‘difference’ is considered a higher-order cognitive function, typically thought to be dependent on top-down neocortical processing. It is therefore surprising that honey bees apparantly have this capacity.
Image credit: Cope et al
09/17/2018
RESEARCH ARTICLE
Migliore et al outline how every neuron is part of a network, exerting its function by transforming multiple spatiotemporal synaptic input patterns into a single spiking output.
Image credit: Migliore et al
09/17/2018
RESEARCH ARTICLE
While the neurobiology of simple and habitual choices is relatively well known, Peev Stoianov et al argue our current understanding of goal-directed choices and planning in the brain is still limited.
Image credit: Stoianov et al
09/12/2018
FEATURED CHANNEL
This Channel brings together all aspects of complexity research and includes interdisciplinary topics from network theory to applications in neuroscience and the social sciences.
Image credit: Andy Lamb
06/28/2012
FEATURED ISSUE IMAGE
This mountain view of the Stubai Alps illustrates a search and optimization strategy for rugged score landscapes.
Image credit: Theresa Niederberger, Gene Center, Ludwig-Maximilians-Universität München.
09/13/2018
FEATURED BLOG POST
Peer Review Week 2018 is all about diversity. To look at the changing scholarly landscape, we interviewed science publishing historian, Aileen Fyfe, who draws on her experience.
Image credit: Figure 1, PONE 0197280
09/17/2018
TOP TWEET
Our new work in @PLOSCompBiol by Nikhil Bhagwat: Using #ArtificialIntelligence to predict decline towards #Alzheimers up to 5 years in advance! Really happy to be able to share this one:
Image credit: Twitter
The articles in this collection consider factors associated with the inclusion and success of women in STEM fields and propose ways to reduce the gender gap.
This Focus Feature addresses some of the most exciting current opportunities and challenges in the field of Network Biology.
The PLOS Computational Biology Methods Section was launched in 2013 and has given computational method development a dedicated space in the journal.
Breast cancer remains a major public health problem...
Nutritional quality of food as represented by the FSAm-NPS nutrient profiling system underlying the Nutri-Score label and cancer risk in Europe: Results from the EPIC prospective cohort study
Welfare-Adjusted Life Years (WALY): A novel metric of animal welfare that combines the impacts of impaired welfare and abbreviated lifespan
Flu’s cues: Exploiting host post-translational modifications to direct the influenza virus replication cycle
Minutes to midnight: Turning back the Doomsday Clock through neglected disease vaccine diplomacy
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