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Table of Contents

December 2017

Two endoflagella are inserted at the poles of the bacterium, elongating in the periplasmic space. Their coordinated clockwise or counterclockwise rotation determines the hook- or spiral-shaped end of the bacterium, allowing or not the translational motility.

These zoonotic bacteria are pathogenic and escape the immune response of their hosts. We demonstrate here that they escape NOD1 and NOD2 responses in humans and mice. Werts et al.

Image Credit: Frédéric Veyrier, INRS-Institut Armand-Frappier, Bacterial Symbionts Evolution, Laval, Quebec, Canada.

Pearls

False friends: Phagocytes as Trojan horses in microbial brain infections

Felipe H. Santiago-Tirado, Tamara L. Doering

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex

Alena Zíková, Zdeněk Verner, Anna Nenarokova, Paul A. M. Michels, Julius Lukeš

Reviews

The role of microbial amyloid in neurodegeneration

Robert P. Friedland, Matthew R. Chapman

The immunological mechanisms that control pneumococcal carriage

Simon P. Jochems, Jeffrey N. Weiser, Richard Malley, Daniela M. Ferreira

Research Articles

Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis

Diego C. P. Rossi, Julie E. Gleason, Hiram Sanchez, Sabrina S. Schatzman, Edward M. Culbertson, Chad J. Johnson, Christopher A. McNees, Carolina Coelho, Jeniel E. Nett, David R. Andes, Brendan P. Cormack, Valeria C. Culotta

Influence of an immunodominant herpes simplex virus type 1 CD8+ T cell epitope on the target hierarchy and function of subdominant CD8+ T cells

Benjamin R. Treat, Sarah M. Bidula, Srividya Ramachandran, Anthony J. St Leger, Robert L. Hendricks, Paul R. Kinchington

LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition

Gwenn Ratet, Ignacio Santecchia, Martine Fanton d’Andon, Frédérique Vernel-Pauillac, Richard Wheeler, Pascal Lenormand, Frédéric Fischer, Pierre Lechat, David A. Haake, Mathieu Picardeau, Ivo G. Boneca, Catherine Werts

Bacteria and bacterial envelope components enhance mammalian reovirus thermostability

Angela K. Berger, Hong Yi, Daniel B. Kearns, Bernardo A. Mainou

Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii

Sachie Kanatani, Jonas M. Fuks, Einar B. Olafsson, Linda Westermark, Benedict Chambers, Manuel Varas-Godoy, Per Uhlén, Antonio Barragan

The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion

Alexsia L. Richards, Patricia J. Sollars, Jared D. Pitts, Austin M. Stults, Ekaterina E. Heldwein, Gary E. Pickard, Gregory A. Smith

Novel Wolbachia-transinfected Aedes aegypti mosquitoes possess diverse fitness and vector competence phenotypes

Johanna E. Fraser, Jyotika Taneja De Bruyne, Iñaki Iturbe-Ormaetxe, Justin Stepnell, Rhiannon L. Burns, Heather A. Flores, Scott L. O’Neill

Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral protease 2A promotes viral replication

Ye Qiu, Xin Ye, Huifang Mary Zhang, Paul Hanson, Guangze Zhao, Lei Tong, Ronald Xie, Decheng Yang

Acquisition of functions on the outer capsid surface during evolution of double-stranded RNA fungal viruses

Carlos P. Mata, Daniel Luque, Josué Gómez-Blanco, Javier M. Rodríguez, José M. González, Nobuhiro Suzuki, Said A. Ghabrial, José L. Carrascosa, Benes L. Trus, José R. Castón

What matters in chronic Burkholderia cenocepacia infection in cystic fibrosis: Insights from comparative genomics

Jaroslav Nunvar, Vaclav Capek, Karel Fiser, Libor Fila, Pavel Drevinek

Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection

A. Trey Belew, Caroline Junqueira, Gabriela F. Rodrigues-Luiz, Bruna M. Valente, Antonio Edson R. Oliveira, Rafael B. Polidoro, Luciana W. Zuccherato, Daniella C. Bartholomeu, Sergio Schenkman, Ricardo T. Gazzinelli, Barbara A. Burleigh, Najib M. El-Sayed, Santuza M. R. Teixeira

Inflammatory monocytes mediate control of acute alphavirus infection in mice

Kelsey C. Haist, Kristina S. Burrack, Bennett J. Davenport, Thomas E. Morrison

Morphological switch to a resistant subpopulation in response to viral infection in the bloom-forming coccolithophore Emiliania huxleyi

Miguel José Frada, Shilo Rosenwasser, Shifra Ben-Dor, Adva Shemi, Helena Sabanay, Assaf Vardi

A parapoxviral virion protein targets the retinoblastoma protein to inhibit NF-κB signaling

Ponnuraj Nagendraprabhu, Sushil Khatiwada, Sabal Chaulagain, Gustavo Delhon, Daniel L. Rock

Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis

Radhika Gopal, Kelli Jackson, Netanel Tzarum, Leopold Kong, Andrew Ettenger, Johnathan Guest, Jennifer M. Pfaff, Trevor Barnes, Andrew Honda, Erick Giang, Edgar Davidson, Ian A. Wilson, Benjamin J. Doranz, Mansun Law

The amino-terminus of the hepatitis C virus (HCV) p7 viroporin and its cleavage from glycoprotein E2-p7 precursor determine specific infectivity and secretion levels of HCV particle types

Solène Denolly, Chloé Mialon, Thomas Bourlet, Fouzia Amirache, François Penin, Brett Lindenbach, Bertrand Boson, François-Loïc Cosset

Increased autophagic sequestration in adaptor protein-3 deficient dendritic cells limits inflammasome activity and impairs antibacterial immunity

Adriana R. Mantegazza, Meghan A. Wynosky-Dolfi, Cierra N. Casson, Ariel J. Lefkovith, Sunny Shin, Igor E. Brodsky, Michael S. Marks

eCD4-Ig promotes ADCC activity of sera from HIV-1-infected patients

Meredith E. Davis-Gardner, Matthew R. Gardner, Barnett Alfant, Michael Farzan

Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein

Kseniya Khamina, Alexander Lercher, Michael Caldera, Christopher Schliehe, Bojan Vilagos, Mehmet Sahin, Lindsay Kosack, Anannya Bhattacharya, Peter Májek, Alexey Stukalov, Roberto Sacco, Leo C. James, Daniel D. Pinschewer, Keiryn L. Bennett, Jörg Menche, Andreas Bergthaler

Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design

Xiangdong Li, Fanli Yang, Xule Hu, Feifei Tan, Jianxun Qi, Ruchao Peng, Min Wang, Yan Chai, Liying Hao, Junhua Deng, Chenyu Bai, Juan Wang, Hao Song, Shuguang Tan, Guangwen Lu, George F. Gao, Yi Shi, Kegong Tian

Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors

Christina Gavegnano, Jessica H. Brehm, Franck P. Dupuy, Aarthi Talla, Susan Pereira Ribeiro, Deanna A. Kulpa, Cheryl Cameron, Stephanie Santos, Selwyn J. Hurwitz, Vincent C. Marconi, Jean-Pierre Routy, Laurent Sabbagh, Raymond F. Schinazi, Rafick Pierre Sékaly

Association of Marek’s Disease induced immunosuppression with activation of a novel regulatory T cells in chickens

Angila Gurung, Nitin Kamble, Benedikt B. Kaufer, Ansar Pathan, Shahriar Behboudi

Stably expressed APOBEC3H forms a barrier for cross-species transmission of simian immunodeficiency virus of chimpanzee to humans

Zeli Zhang, Qinyong Gu, Marc de Manuel Montero, Ignacio G. Bravo, Tomas Marques-Bonet, Dieter Häussinger, Carsten Münk

Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation

Jiaoyu Shan, Binbin Zhao, Zhao Shan, Jia Nie, Rong Deng, Rui Xiong, Andy Tsun, Weiqi Pan, Hanzhi Zhao, Ling Chen, Ying Jin, Zhikang Qian, Kawing Lui, Rui Liang, Dan Li, Bing Sun, Dimitri Lavillette, Ke Xu, Bin Li

Related Articles

Adenoviral vaccine induction of CD8+ T cell memory inflation: Impact of co-infection and infection order

Lian N. Lee, Beatrice Bolinger, Zoltan Banki, Catherine de Lara, Andrew J. Highton, Julia M. Colston, Claire Hutchings, Paul Klenerman

Lower temperatures reduce type I interferon activity and promote alphaviral arthritis

Natalie A. Prow, Bing Tang, Joy Gardner, Thuy T. Le, Adam Taylor, Yee S. Poo, Eri Nakayama, Thiago D. C. Hirata, Helder I. Nakaya, Andrii Slonchak, Pamela Mukhopadhyay, Suresh Mahalingam, Wayne A. Schroder, William Klimstra, Andreas Suhrbier

Human immunodeficiency virus type-1 (HIV-1) evades antibody-dependent phagocytosis

Johannes S. Gach, Margaux Bouzin, Marcus P. Wong, Veronika Chromikova, Andrea Gorlani, Kuan-Ting Yu, Brijesh Sharma, Enrico Gratton, Donald N. Forthal

HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes

Olga Moreno-Gonzalo, Marta Ramírez-Huesca, Noelia Blas-Rus, Danay Cibrián, María Laura Saiz, Inmaculada Jorge, Emilio Camafeita, Jesús Vázquez, Francisco Sánchez-Madrid

Host triacylglycerols shape the lipidome of intracellular trypanosomes and modulate their growth

Felipe Gazos-Lopes, Jessica L. Martin, Peter C. Dumoulin, Barbara A. Burleigh

RNA elongation by respiratory syncytial virus polymerase is calibrated by conserved region V

Molly R. Braun, Laure R. Deflubé, Sarah L. Noton, Michael E. Mawhorter, Chadene Z. Tremaglio, Rachel Fearns

Correction

Correction: Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation

Jennifer Mesureur, Joana R. Feliciano, Nelly Wagner, Margarida C. Gomes, Lili Zhang, Monica Blanco-Gonzalez, Michiel van der Vaart, David O’Callaghan, Annemarie H. Meijer, Annette C. Vergunst

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