April 29, 2022

Fifty years of struggle to control cutaneous leishmaniasis in the highest endemic county in Iran

In this longitudinal observational study to assess the impact of interventions applied between 1971 and 2020 in Bam county, Iran, Mohammadreza Aflatoonian and colleagues find that the main factors negatively impacting to cutaneous leishmaniasis control are cessation of malaria spraying activity, expansion of the city spaces, and a massive earthquake creating new breeding potentials for the vectors.

Image credit: Aflatoonian M, et al. pntd.0010271

2021 Year in Review

Thank you to all of our authors, reviewers, and editors who helped us achieve so much last year, despite another challenging year of the COVID-19 pandemic. You can read more about the PLOS NTDs community's 2021 accomplishments by clicking on the '2021' button.

2021

04/28/2022

Review

Finding a chink in the armor: Update, limitations, and challenges toward successful antivirals against flaviviruses

Thamil Vaani Komarasamy and colleagues review the latest progress in the development of both new and repurposed direct-acting antivirals, host-targeting antivirals, and multitarget antivirals against flaviviruses, which have been evaluated both in vitro and in vivo, with an emphasis on their targets and mechanisms. Read the Review.

Image credit: Cynthia Goldsmith, P.E. Rollin, USCDCP, Wikimedia Commons

Finding a chink in the armor: Update, limitations, and challenges toward successful antivirals against flaviviruses

Recently Published Articles

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Current Issue April 2022

03/17/2022

Viewpoints

Initiatives to address leprosy as a human rights issue through the mandate of UN Special Rapporteur: Achievements and challenges

Considering the proper implementation of the principles and guidelines to be key to eliminating the discrimination that persons affected by leprosy and their families face in various parts of the world, Takahiro Nanri looks at the contribution the UN Special Rapporteur can make. Read the Viewpoint.

Image credit: Makaristos, Wikimedia Commons

Initiatives to address leprosy as a human rights issue through the mandate of UN Special Rapporteur: Achievements and challenges

03/03/2022

Symposium

In vivo reflectance confocal microscopy, dermoscopy, high-frequency ultrasonography, and histopathology features in a case of chromoblastomycosis

Gabriela A. Giraldelli and colleagues present the case of a 60-year-old male patient complaining of a 12-month history of a progressively enlarging painful ulcer on his right calf. Read the Symposium.

Image credit: Giraldelli GA, et al. pntd.0010226

In vivo reflectance confocal microscopy, dermoscopy, high-frequency ultrasonography, and histopathology features in a case of chromoblastomycosis

04/26/2022

Research Article

Field-releases of IIT-SIT males for Aedes aegypti control in Mexico

In the first open-field pilot implementation of Wolbachia IIT-SIT in Mexico and Latin-America, Abdiel Martín-Park and colleagues confirm that inundative male releases can significantly reduce natural populations of Ae. aegypti. Read the Author Summary.

Image credit: Martín-Park A, et al. pntd.0010324

04/20/2022

Research Article

Transplacental Zika virus transmission in ex vivo perfused human placentas

Thomas Langerak and colleagues demonstrate that DENV antibodies significantly increase ZIKV uptake in perfused human placentas and that this increased uptake is neonatal Fc-receptor-dependent. Read the Author Summary.

Image credit: Langerak T, et al. pntd.0010359

04/08/2022

Research Article

Extensive public health initiatives drive the elimination of Aedes aegypti from a town in regional Queensland

Brendan J. Trewin and colleagues describe a model of the public health intervention which successfully reduces the Ae. aegypti population below detection thresholds, using source reduction, insecticides and novel, intensive genetic surveillance methods. Read the Author Summary.

Image credit: Trewin BJ, et al. pntd.0010243

04/20/2022

Research Article

Diverse and atypical manifestations of Q fever in a metropolitan city hospital: Emerging role of next-generation sequencing for laboratory diagnosis of Coxiella burnetii

By Fanfan Xing and colleagues. Read the Author Summary.

Image credit: Xing F, et al. pntd.0010364

04/07/2022

Research Article

Smartphone multiplex microcapillary diagnostics using Cygnus: Development and evaluation of rapid serotype-specific NS1 detection with dengue patient samples

By Sarah Helen Needs and colleagues. Read the Author Summary.

Image credit: Needs SH, et al. pntd.0010266

04/13/2022

Research Article

Experimental Schistosoma japonicum-induced pulmonary hypertension

By Biruk Kassa and colleagues. Read the Author Summary.

Image credit: Kassa B, et al. pntd.0010343

04/21/2022

Research Article

Pathological and immunological evaluation of different regimens of praziquantel treatment in a mouse model of Schistosoma mansoni infection

By Ulrich Membe Femoe and colleagues. Read the Author Summary.

Image credit: Membe Femoe U, et al. pntd.0010382

PLOS NTDs COVID-19 Research

Berbamine hydrochloride potently inhibits SARS-CoV-2 infection by blocking S protein-mediated membrane fusion

By Zhe-Rui Zhang and colleagues
SARS-CoV-2 testing in South America

By Byron Freire-Paspuel and colleagues
Monoclonal antibody pairs against SARS-CoV-2 for rapid antigen test development

By Nol Salcedo and colleagues
An investigation of spatial-temporal patterns and predictions of the coronavirus 2019 pandemic in Colombia, 2020–2021

By Amna Tariq and colleagues
Conceptual model of low-cost improvised bubble continuous positive airway pressure device for adults and its potential use in the COVID-19 pandemic

By Himal Kharel and colleagues

Additional PLOS NTDs Research

Helminth infection modulates number and function of adipose tissue Tregs in high fat diet-induced obesity

By Camila P. Queiroz-Glauss and colleagues
Preexisting Trichinella spiralis infection attenuates the severity of Pseudomonas aeruginosa-induced pneumonia

By Shao Rong Long and colleagues
Onchocerca volvulus-specific antibody and cellular responses in onchocerciasis patients treated annually with ivermectin for 30 years and exposed to parasite transmission in central Togo

By Saskia I. Johanns and colleagues
Simple clinical and laboratory predictors to improve empirical treatment strategies in areas of high scrub typhus and dengue endemicity in central Vietnam

By Hanh Thi Duc Tran and colleagues
Combining rapid diagnostic tests to estimate primary and post-primary dengue immune status at the point of care

By Joseph R. Biggs and colleagues

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PLOS Neglected Tropical Diseases | ISSN: 1935-2735 (online)

Fifty years of struggle to control cutaneous leishmaniasis in the highest endemic county in Iran

2021 Year in Review

Thank you to all of our authors, reviewers, and editors who helped us achieve so much last year, despite another challenging year of the COVID-19 pandemic. You can read more about the PLOS NTDs community's 2021 accomplishments by clicking on the '2021' button.

Finding a chink in the armor: Update, limitations, and challenges toward successful antivirals against flaviviruses

Recently Published Articles

Initiatives to address leprosy as a human rights issue through the mandate of UN Special Rapporteur: Achievements and challenges

In vivo reflectance confocal microscopy, dermoscopy, high-frequency ultrasonography, and histopathology features in a case of chromoblastomycosis

Field-releases of IIT-SIT males for Aedes aegypti control in Mexico

Transplacental Zika virus transmission in ex vivo perfused human placentas

Extensive public health initiatives drive the elimination of Aedes aegypti from a town in regional Queensland

Diverse and atypical manifestations of Q fever in a metropolitan city hospital: Emerging role of next-generation sequencing for laboratory diagnosis of Coxiella burnetii

Smartphone multiplex microcapillary diagnostics using Cygnus: Development and evaluation of rapid serotype-specific NS1 detection with dengue patient samples

Experimental Schistosoma japonicum-induced pulmonary hypertension

Pathological and immunological evaluation of different regimens of praziquantel treatment in a mouse model of Schistosoma mansoni infection

Berbamine hydrochloride potently inhibits SARS-CoV-2 infection by blocking S protein-mediated membrane fusion

SARS-CoV-2 testing in South America

Monoclonal antibody pairs against SARS-CoV-2 for rapid antigen test development

An investigation of spatial-temporal patterns and predictions of the coronavirus 2019 pandemic in Colombia, 2020–2021

Conceptual model of low-cost improvised bubble continuous positive airway pressure device for adults and its potential use in the COVID-19 pandemic

Helminth infection modulates number and function of adipose tissue Tregs in high fat diet-induced obesity

Preexisting Trichinella spiralis infection attenuates the severity of Pseudomonas aeruginosa-induced pneumonia

Onchocerca volvulus-specific antibody and cellular responses in onchocerciasis patients treated annually with ivermectin for 30 years and exposed to parasite transmission in central Togo

Simple clinical and laboratory predictors to improve empirical treatment strategies in areas of high scrub typhus and dengue endemicity in central Vietnam

Combining rapid diagnostic tests to estimate primary and post-primary dengue immune status at the point of care

Publish with PLOS

2021 Year in Review

Thank you to all of our authors, reviewers, and editors who helped us achieve so much last year, despite another challenging year of the COVID-19 pandemic. You can read more about the PLOS NTDs community's 2021 accomplishments by clicking on the '2021' button.

Recently Published Articles

Publish with PLOS

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