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February 21, 2025

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02/20/2025

Editorial

Revisiting What Constitutes a Neglected Tropical Disease?

PLOS Neglected Tropical Diseases publishes research devoted to pathogenesis and other clinical aspects, epidemiology, prevention, diagnosis, treatment, and control of the neglected tropical diseases (NTDs), as well as work relevant to public health policy. We define NTDs as poverty-promoting infectious diseases that can negatively impact the quality of life in rural areas and poor urban areas of low- and middle-income countries but which can also affect specific...

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Revisiting What Constitutes a Neglected Tropical Disease?

Recently Published Articles

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Current Issue

Current Issue April 2025

02/06/2025

Research Article

Comprehensive proteolytic profiling of Aedes aegypti mosquito midgut extracts: Unraveling the blood meal protein digestion system

To sustain the gonotrophic cycle, the Aedes aegypti mosquito must acquire a blood meal from a human or other vertebrate host. However, in the process of blood feeding, the mosquito may facilitate the transmission of several bloodborne viral pathogens (e.g., dengue, Zika, and chikungunya). The blood meal is essential...

Image credit: pntd.0012555

Comprehensive proteolytic profiling of Aedes aegypti mosquito midgut extracts: Unraveling the blood meal protein digestion system

02/18/2025

Research Article

Prevalence of antibodies against dengue virus in the city of Buenos Aires: Results of a probabilistic population survey

Dengue is a rapidly growing global health issue. In Argentina, the disease burden is primarily based on case reports or retrospective series; however, there are no prospective probabilistic studies available. To estimate the seroprevalence of antibodies against the dengue virus (DENV) in adult residents of Buenos Aires, at the end of the 2023 season, which culminated in...

Image credit: NIAID

Prevalence of antibodies against dengue virus in the city of Buenos Aires: Results of a probabilistic population survey

01/23/2025

Policy Platform

Leptospirosis, melioidosis, and rickettsioses in the vicious circle of neglect

The global priorities in the field of infectious diseases are constantly changing. While emerging viral infections have regularly dominated public health attention, which has only intensified after the COVID-19 pandemic, numerous bacterial diseases have previously caused, and continue to cause, significant morbidity and mortality—deserving equal...

Leptospirosis, melioidosis, and rickettsioses in the vicious circle of neglect

Image credit: The American journal of tropical medicine

02/19/2025

Research Article

Impact of a multi-pronged cholera intervention in an endemic setting

Cholera is a bacterial water-borne diarrheal disease transmitted via the fecal-oral route that causes high morbidity in sub-Saharan Africa and Asia. It is preventable with vaccination, and Water, Sanitation, and Hygiene (WASH) improvements. However, the impact of vaccination in endemic settings remains unclear. Cholera is endemic in the city...

Impact of a multi-pronged cholera intervention in an endemic setting

Image credit: pntd.0012867

01/03/2025

Review

Progress in antileishmanial drugs: Mechanisms, challenges, and prospects

Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, continues to pose global health challenges. Current treatments face issues like resistance, safety, efficacy, and cost. This review covers the discovery, mechanisms of action, clinical applications, and limitations of key antileishmanial agents: pentavalent antimonials...

Progress in antileishmanial drugs: Mechanisms, challenges, and prospects

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PLOS Neglected Tropical Diseases | ISSN: 1935-2735 (online)