Advertisement
A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis

May 23, 2019

A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis

Paula MacGregor, Andrea L. Gonzalez-Munoz, Mark Carrington, and colleagues show that antibody-drug conjugates can be re-purposed from cancer immunotherapeutics to anti-protozoals by changing the specificity of the immunoglobulin to target a trypanosome cell surface receptor.


Image credit: MacGregor P, Gonzalez-Munoz AL, Jobe F, Taylor MC, Rust S, Sandercock AM, et al. (2019)

Flubendazole in Onchocerciasis

Explore our collection on flubendazole as a treatment for onchocerciasis.

Click Here

10/18/2018

Editorial

Catalyzing NTD gender and equity research: A call for papers

For NTDs, sex and gender roles can have a profound effect on healthcare access, health outcomes, and caregiver responsibilities. The Uniting to Combat NTDs Equity Working Group, in partnership with PLOS Neglected Tropical Diseases, is inviting manuscripts for a special journal supplement on gender and NTDs. Read the Editorial.

Image credit: Possible Health, Flickr

Catalyzing NTD gender and equity research: A call for papers

Recently Published Articles

Current Issue

Current Issue April 2019

05/23/2019

Research Article

Genomic diversity of the genus Leptospira

Mathieu Picardeau, Antony T. Vincent, Olivier Schiettekatte, and colleagues perform a comparative genomic analysis of species of the Leptospira genus to identify genes or genome features that are specific to infectious species, which provides insight into virulence evolution in these atypical bacteria and allows refinement of the Leptospira classification. Read the Author Summary

Genomic diversity of the genus Leptospira

Image credit: Vincent AT, Schiettekatte O, Goarant C, Neela VK, Bernet E, Thibeaux R, et al. (2019)

05/20/2019

Research Article

T. cruzi surface mucins and parasite development in the triatomine vector

María de los Milagros Cámara, Carlos A. Buscaglia, and colleagues show that Gp35/50 kDa mucins, the major T. cruzi epimastigote surface glycoproteins, specifically adhere to the internal cuticle of the rectal ampoule of the triatomine vector, a critical step leading to their differentiation into mammal-infective metacyclic forms. Read the Author Summary

T. cruzi surface mucins and parasite development in the triatomine vector

Image credit: Cámara MdlM, Balouz V, Centeno Cameán C, Cori CR, Kashiwagi GA, Gil SA, et al. (2019)

05/20/2019

Research Article

The prevalence of Leptospira among invasive small mammals on Puerto Rican cattle farms

Kathryn M. Benavidez, Iván Castro-Arellano, and colleagues provide an initial exploration of wild mammal reservoirs for Leptospira in Puerto Rico, and highlight the need for management of these species to potentially decrease pathogen transmission rates in both humans and cattle.. Read the Author Summary

The prevalence of Leptospira among invasive small mammals on Puerto Rican cattle farms

Image credit: Benavidez KM, Guerra T, Torres M, Rodriguez D, Veech JA, Hahn D, et al. (2019)

Get new content from PLOS Neglected Tropical Diseases in your inbox

Thank you! You have successfully subscribed to the PLOS Neglected Tropical Diseases newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

Try again