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05/30/2023

Research Article

Prevalence of Thiamine Deficiency in Pregnancy and its impact on fetal outcome in an area endemic for thiamine deficiency

Pregnancy is a metabolically challenging state with increased nutritional demand. Thiamine is an important cofactor in various metabolic pathways and thus its deficiency could have a serious impact on both maternal and fetal outcomes. Kashmir has thiamine deficiency in endemic proportions, with multiple reports of infantile beriberi, postpartum neuropathy, and gastric beriberi. This prompted us to assess the extent...

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Prevalence of Thiamine Deficiency in Pregnancy and its impact on fetal outcome in an area endemic for thiamine deficiency

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Current Issue May 2023

05/30/2023

Research Article

An economic evaluation of Wolbachia deployments for dengue control in Vietnam

Dengue is a major public health challenge and a growing problem due to climate change. The release of Aedes aegypti mosquitoes infected with the intracellular bacterium Wolbachia is a novel form of vector control against dengue. However, there remains a need to evaluate the benefits of such an intervention at a large scale. In this paper, we evaluate the potential economic impact and cost-effectiveness of scaled Wolbachia deployments as a form of dengue control...

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An economic evaluation of Wolbachia deployments for dengue control in Vietnam

05/26/2023

Research Article

Onchocerciasis-associated epilepsy in Maridi, South Sudan: Modelling and exploring the impact of control measures against river blindness

Onchocerciasis, also known as “river blindness”, is caused by the bite of infected female blackflies (genus Simuliidae) that transmit the parasite Onchocerca volvulus. A high onchocerciasis microfarial load increases the risk to develop epilepsy in children between the ages of 3 and 18 years. In resource-limited settings in Africa where onchocerciasis...

Image credit: pntd.0011320

Onchocerciasis-associated epilepsy in Maridi, South Sudan: Modelling and exploring the impact of control measures against river blindness

05/25/2023

Viewpoints

Simplifying screening for Trypanosoma cruzi in pregnant persons and their infants

Mother-to-child transmission is a major source of Trypanosoma cruzi infection. The Pan American Health Organization (PAHO) recommends T. cruzi serological screening of all pregnant persons when part of national policy. The objective of screening pregnant persons is to identify infected infants who could be treated early in life. The World Health...

Simplifying screening for Trypanosoma cruzi in pregnant persons and their infants

Image credit: Public Domain, CC0

05/25/2023

Research Article

Multi-centric evaluation of Biomeme Franklin Mobile qPCR for rapid detection of Mycobacterium ulcerans in clinical specimens

The gold standard for detection of Mycobacterium ulcerans is PCR due to its high accuracy in confirmation of suspected cases. But the available PCR assays are designed for standard size thermocyclers which are immobile and suited for reference laboratories often located long distances from endemic communities. This makes it a challenge to obtain...

Multi-centric evaluation of Biomeme Franklin Mobile qPCR for rapid detection of Mycobacterium ulcerans in clinical specimens

Image credit: pntd.0011373

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PLOS Neglected Tropical Diseases | ISSN: 1935-2735 (online)