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Informal genomic surveillance of regional distribution of Salmonella Typhi

September 12, 2019

Informal genomic surveillance of regional distribution of Salmonella Typhi

Danielle J. Ingle and colleagues demonstrate how routine whole-genome sequencing data produced by Public Health England can be further mined for informal passive surveillance of Salmonella Typhi circulating in different geographical regions where typhoid is endemic.

Image credit: Ingle DJ, Nair S, Hartman H, Ashton PM, Dyson ZA, Day M, et al. (2019)

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08/29/2019

Review

Rickettsial infections of the central nervous system

In this Review, Zuzana Sekeyová, Pierre Edouard Fournier, and colleagues analyze and summarize the features and correlated findings of central nervous system rickettsial infections in order to focus attention on these intriguing but frequently neglected illnesses. Read the Review

Image credit: Sekeyová Z, Danchenko M, Filipčík P, Fournier PE (2019)

Rickettsial infections of the central nervous system

Recently Published Articles

Current Issue

Current Issue August 2019

09/12/2019

Viewpoints

Chikungunya-attributable deaths: A neglected outcome of a neglected disease

Antonio S. Lima Neto, Marcia C. Castro, and colleagues present evidence that chikungunya-related deaths are vastly under-reported worldwide and argue that it is imperative that international agencies formally recognize the high lethality of chikungunya in specific groups in order to reorient disease surveillance. Read the Viewpoint

Image credit: James Gathany, CDC, Wikimedia Commons

Chikungunya-attributable deaths: A neglected outcome of a neglected disease

08/08/2019

Editorial

DR Congo and Nigeria: New neglected tropical disease threats and solutions for the bottom 40%

Peter Hotez outlines the impending health crisis in the Democratic Republic of Congo and Nigeria as they are projected to be home to almost one-half of the world’s population living in extreme poverty by 2050. Dr. Hotez urges that now is the time to embark on long-term strategies for disease control, including the prioritization of the new biotechnologies that will be needed. Read the Editorial

Image credit: NASA, Wikimedia Commons

DR Congo and Nigeria: New neglected tropical disease threats and solutions for the bottom 40%

09/11/2019

Research Article

Development and validation of a pen side test for Rift Valley fever

Catherine Cêtre-Sossah and colleagues report the development and the evaluation of the diagnostic performance characteristics of a pen-side test found to be a highly accurate and valuable first-line diagnostic tool for on-site RVF detection. Read the Author Summary

Development and validation of a pen side test for Rift Valley fever

Image credit: Cêtre-Sossah C, Pédarrieu A, Juremalm M, Jansen Van Vuren P, Brun A, Ould EL Mamy AB, et al. (2019)

09/10/2019

Research Article

Neutrophil Extracellular Traps contribute to the pathogenesis of leprosy type 2 reactions

Camila Oliveira da Silva, André Alves Dias, Maria Cristina Vidal Pessolani, and colleagues shed light on the pathogenesis of type 2 reactions to leprosy to hopefully contribute to the identification of biomarkers for early diagnosis and emergence of novel alternative therapies in the near future. Read the Author Summary

Neutrophil Extracellular Traps contribute to the pathogenesis of leprosy type 2 reactions

Image credit: da Silva CO, Dias AA, da Costa Nery JA, de Miranda Machado A, Ferreira H, Rodrigues TF, et al. (2019)

09/12/2019

Research Article

Intestinal UDP-glucuronosyltransferase as a therapeutic target of lymphatic filariasis

Alexander F. Flynn, Edward Mitre, and colleagues determined that B. malayi intestinal UDP-glucuronosyltransferase is essential for B. malayi adult worm survival, as gene-expression knockdown rapidly decreased motility, fecundity, and microfilarial release, making it a potential therapeutic target. Read the Author Summary

Intestinal UDP-glucuronosyltransferase as a therapeutic target of lymphatic filariasis

Image credit: Flynn AF, Joyce MG, Taylor RT, Bennuru S, Lindrose AR, Sterling SL, et al. (2019)

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