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07/03/2023

Research Article

Smartphone-readable RPA-LFA for the high-sensitivity detection of Leishmania kDNA using nanophosphor reporters

Early diagnosis of infectious diseases improves outcomes by enabling earlier delivery of effective treatment, and helps prevent further transmission by undiagnosed persons. We demonstrated a proof-of-concept assay combining isothermal amplification and lateral flow assay (LFA) for early diagnosis of cutaneous leishmaniasis, a vector-borne infectious disease that affects ca. 700,000 to 1.2 million people annually...

Image credit: pntd.0011436

Smartphone-readable RPA-LFA for the high-sensitivity detection of Leishmania kDNA using nanophosphor reporters

07/31/2023

Research Article

Towards the sustainable elimination of gambiense human African trypanosomiasis in Côte d’Ivoire using an integrated approach

Human African trypanosomiasis is a parasitic disease caused by trypanosomes among which Trypanosoma brucei gambiense is responsible for a chronic form (gHAT) in West and Central Africa. Its elimination as a public health problem (EPHP) is being achieved. Côte d’Ivoire was one of the first countries to be validated by WHO in 2020 and this was particularly challenging as the country still reported around...

Image credit: pntd.0011514

Towards the sustainable elimination of gambiense human African trypanosomiasis in Côte d’Ivoire using an integrated approach

07/31/2023

Research Article

Candida haemulonii complex, an emerging threat from tropical regions?

Candida haemulonii complex-related species are pathogenic yeasts closely related to Candida auris with intrinsic antifungal resistance, but few epidemiological data are available. We analyzed clinical and demographic characteristics of patients with fungemia due to C. haemulonii complex and related species (C. pseudohaemulonii, C. vulturna)...

 Candida haemulonii complex, an emerging threat from tropical regions?

Image credit: pntd.0011453

07/27/2023

Research Article

Genetic differentiation among Aedes aegypti populations from different eco-geographical zones of India

The present study explicitly evaluated the genetic structure of Aedes aegypti Linn, the vector of dengue, chikungunya, and Zika viruses, across different geo-climatic zones of India and also elucidated the impact of ecological and topographic factors. After data quality checks and removal of samples with excess null alleles, the final analysis...

Genetic differentiation among Aedes aegypti populations from different eco-geographical zones of India

Image credit: pntd.0011486

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PLOS Neglected Tropical Diseases | ISSN: 1935-2735 (online)