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Zika viruses of African and Asian lineages cause fetal harm in a mouse model of vertical transmission

April 17, 2019

Zika viruses of African and Asian lineages cause fetal harm in a mouse model of vertical transmission

Matthew T. Aliota and colleagues show that ZIKV of both African and Asian/American lineages can cause fetal harm in the mouse pregnancy model and that this capacity does not require asparagine at amino acid residue 139. Their results suggest that ZIKV infection during pregnancy poses a risk for fetal harm in all regions where the virus is endemic.

Image credit: Jaeger AS, Murrieta RA, Goren LR, Crooks CM, Moriarty RV, Weiler AM, et al. (2019)

Flubendazole in Onchocerciasis

Explore our collection on flubendazole as a treatment for onchocerciasis.

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04/04/2019

Editorial

Female genital schistosomiasis and HIV/AIDS: Reversing the neglect of girls and women

Peter J. Hotez and colleagues argue that female genital schistosomiasis is likely the most neglected gynecologic condition and HIV/AIDS cofactor across sub-Saharan Africa and explain the opportunity to prevent new HIV/AIDS infections through highly cost-effective schistosomiasis control and elimination in Africa. Read the Editorial, here

Image credit: Georgie Pauwels, Flickr

Female genital schistosomiasis and HIV/AIDS: Reversing the neglect of girls and women

Recently Published Articles

Current Issue

Current Issue March 2019

04/18/2019

Viewpoints

Epidemiological trend of chikungunya outbreak in Pakistan: 2016–2018

Muhammad Masroor Alam and colleagues present an update on CHIKV testing at National Institute of Health in Islamabad and their findings indicate the need for  strengthening of laboratory services at provincial and at-risk districts to generate accurate information for patient management and sensible allocation of health resources. Read the Viewpoint here

Image credit: Badar N, Salman M, Ansari J, Ikram A, Qazi J, Alam MM (2019)

Epidemiological trend of chikungunya outbreak in Pakistan: 2016–2018

04/18/2019

Policy Platform

Combating infectious disease epidemics through China’s Belt and Road Initiative

Xiao-Nong Zhou and colleagues aim to analyse the existing spectrum of the main infectious diseases in epidemics, the potential negative effect on the economy, and the challenges to elimination, as well as to explore opportunities and a feasible approach of global disease control with specific consideration of the Belt and Road Initiative. Read the Policy Platform here

Image credit: Chen J, Bergquist R, Zhou X-N, Xue J-B, Qian M-B (2019)

Combating infectious disease epidemics through China’s Belt and Road Initiative

04/15/2019

Research Article

Antibody response to Japanese encephalitis vaccination in Nepal

Lance Turtle, Hannah E. Brindle, and colleagues show that DENV IgM is present in Nepali subjects who have not travelled to India, suggesting that DENV may have become established in Nepal. They propose that further vaccine campaigns should be considered in areas that have had fewer vaccination campaigns. Read the Author Summary

Antibody response to Japanese encephalitis vaccination in Nepal

Image credit: Tech. Sgt. James Stewart, U.S. Air Force, Wikimedia Commons

04/17/2019

Research Article

Transmission of Leishmania from non-human primates to sand flies

Renato Lima Santos and colleagues evaluate the transmissibility potential of visceral leishmaniasis by non-human primates through xenodiagnosis using Lu. longipalpis, identify phlebotomine species prevalent in the area of the primates' enclosure, and assess infection by Leishmania in captured phlebotomine specimens. Read the Author Summary

Transmission of Leishmania from non-human primates to sand flies

Image credit: Ray Wilson, Liverpool School of Tropical Medicine, Wikimedia Commons

04/15/2019

Research Article

Aedes aegypti HPX8C modulates immune responses against viral infection

Ai-Hua Zheng, Cheng-Feng Qin, Zhen Zou, and colleagues obtain midgut transcriptomes of immunity-related genes from DENV-challenged mosquitoes and  identify ROS-regulated antioxidant genes as candidate genes related to DENV infection. Read the Author Summary

Aedes aegypti HPX8C modulates immune responses against viral infection

Image credit: Wang J-M, Cheng Y, Shi Z-K, Li X-F, Xing L-S, Jiang H, et al. (2019)

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